From owner-acedb@net.bio.net Wed Aug 07 23:00:00 1996
Path: biosci!agate!howland.erols.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!in3.uu.net!ott.istar!istar.net!van.istar!west.istar!n1van.istar!van-bc!news.mindlink.net!news.atl.bellsouth.net!newsrelay.iastate.edu!news.iastate.edu!macgrant.agron.iastate.edu!user
From: dgrant@iastate.edu (David Grant)
Newsgroups: bionet.software.acedb
Subject: MacACE
Date: Thu, 08 Aug 1996 09:31:06 -0500
Organization: Iowa State University
Lines: 5
Message-ID: <dgrant-0808960931060001@macgrant.agron.iastate.edu>
NNTP-Posting-Host: macgrant.agron.iastate.edu

Can anyone shed some light on the status of MacACE? Will there be an 
update to match the current 4.3 release? If not, will the major bugs in 
the current 4.0/4.1 version be fixed?

David Grant   dgrant@iastate.edu

From owner-acedb@net.bio.net Thu Aug 08 23:00:00 1996
Path: biosci!biosci!not-for-mail
From: Petar_Stojadinovic@sequana.com (Petar Stojadinovic)
Newsgroups: bionet.biophysics,bionet.genome.chromosomes,bionet.neuroscience,bionet.protista,bionet.software,bionet.software.acedb,bionet.software.gcg,bionet.software.srs,bionet.software.staden,bionet.software.x-plor,bionet.structural-nmr,bionet.toxicology,bionet.users.addresses,bionet.women-in-bio,bionet.xtallography
Subject: Clinical Lab Automation & Development, Computational Biology,Biotech Engineering
Date: 8 Aug 1996 22:36:25 -0700
Organization: Sequana Therapeutics, Inc.
Lines: 13
Sender: biohelp@net.bio.net
Distribution: world
Message-ID: <Petar_Stojadinovic-0508961929310001@198.207.137.191>
NNTP-Posting-Host: net.bio.net
Xref: biosci bionet.biophysics:2205 bionet.genome.chromosomes:1303 bionet.neuroscience:15213 bionet.protista:584 bionet.software:16272 bionet.software.acedb:956 bionet.software.gcg:1948 bionet.software.srs:286 bionet.software.staden:221 bionet.software.x-plor:680 bionet.structural-nmr:1434 bionet.toxicology:849 bionet.users.addresses:3079 bionet.women-in-bio:5326 bionet.xtallography:2789

Wanted: Abstracts, Interested members to Join Engineers in Biotechnology
Subchapter of Assoc. of Laboratory Automation (ALA) or ICAR in Europe.
please send email to :
petar@sequana.com

PS: Do you know how I may enter a new newsgroup in alt as alt.biotech.engineers?
Thank you.

Petar Stojadinovic
Sequana Therapeutics Inc.
Engineering Dept.
Phone: 619-6468263
email: petar@sequana.com

From owner-acedb@net.bio.net Thu Aug 08 23:00:00 1996
Path: biosci!daresbury!not-for-mail
From: mieg@kaa.crbm.cnrs-mop.fr (Danielle et jean Thierry-Mieg)
Newsgroups: bionet.software.acedb
Subject: Re:  acedb 4.3 updates
Date: 9 Aug 1996 10:40:10 +0100
Lines: 4
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <4uf11q$q85@mserv1.dl.ac.uk>
Original-To: rla@galactose.mc.duke.edu

in fact 4-...13 became too big and convoluted so WS1 REPLACES the other serie
so you should save your personal modif if any by dumping them out as an eca file
then rm $ACEDB/database/ACEDB.wrm
and rerun and read the new serie of files

From owner-acedb@net.bio.net Mon Aug 12 23:00:00 1996
Path: biosci!rutgers!csn!nntp-xfer-1.csn.net!ncar!imci4!newsfeed.internetmci.com!cpk-news-hub1.bbnplanet.com!cpk-news-feed1.bbnplanet.com!sprout.nal.usda.gov!usenet
From: Doug Bigwood <dbigwood@gig.usda.gov>
Newsgroups: bionet.software.acedb,misc.test
Subject: JOBs: Java/Perl Programmer/Analysts (2) wanted for genome
				 project
Date: Tue, 13 Aug 1996 10:32:02 -0400
Organization: Genome Informatics Group, University of Maryland
Lines: 80
Message-ID: <321091E2.2499@gig.usda.gov>
NNTP-Posting-Host: locus.gig.usda.gov
Mime-Version: 1.0
Content-Type: text/plain; charset=us-ascii
Content-Transfer-Encoding: 7bit
X-Mailer: Mozilla 3.0b6 (X11; I; SunOS 5.5 sun4m)
Xref: biosci bionet.software.acedb:958 misc.test:126480

Two programmer/analyst positions are available immediately for
the Agricultural Genome Information Service (AGIS) project.  This
project, an ongoing cooperative effort between the University of
Maryland and the USDA, provides genome data to scientists and
other users throughout the world.  If hired, you will be working
in a state-of-the-art environment developing the next generation
of software for Internet access of our databases and other
information.  Most of the development will be in Java and Perl 5
(and perhaps C) on Sun/Solaris and DEC Alpha systems.  Experience
in these languages in a real-world situation is strongly
preferred and Unix experience is essential.  Also, experience
with ACeDB or another object-oriented database package is a big
plus.  Knowledge of molecular biology/genetics or experience with
scientific databases is desired as well.  You must be able to
work cooperatively with group members.  Creativity is strongly
encouraged.  Excellent benefits. The formal announcement is
below.
 
----------------------------------------------------------------
 
                    PROGRAMMER FOR AGRICULTURAL GENOME PROJECT
 
TITLE:              Computer Programmer/Analyst (2 positions)
 
LOCATION:           National Agricultural Library, Beltsville MD.
 
CATEGORY:           One year contract position with possible
                    renewal.
 
SALARY:             $35,000 minimum.  Actual salary commensurate
                    with experience. (This position has a 40-hour
                    work week.)

RESPONSIBILITIES:   Works under the supervision of the project
                    manager at the University of Maryland at
                    College Park (UMCP), to provide programming
                    services in support of the Agricultural
                    Genome Information Service, a cooperative
                    effort between UMCP and the U.S. Dept. of
                    Agriculture.  This program is located at the
                    National Agricultural Library (NAL).  Works
                    directly with the Manager of the Genome
                    Informatics Group to develop software for the
                    scientific community in USDA and cooperating
                    institutions.  This is a one-year, renewable
                    contract position, under a cooperative
                    agreement between the NAL and UMCP.
 
QUALIFICATIONS:     Required:  Degree in information/computer
                    science from an accredited institution, or
                    its equivalent in experience.
 
EXPERIENCE:         Required:  Excellent knowledge of the Unix
                    operating system.
                    Preferred: Extensive experience with Perl 5
                    (extensive experience in another object-
                    oriented language will also be considered)
                    and C; real-world experience with Java;
                    knowledge of World Wide Web server operation
                    and configuration, and CGI program scripting;
                    background or college coursework in biology
                    or chemistry; greater than 3 years working
                    experience, but recent college graduate will
                    be considered.
 
BENEFITS:           22 working days annual leave; 11 paid
                    holidays; 15 days sick leave; other benefits
                    may be negotiable.
 
POSITION AVAILABLE: Immediately.
 
APPLICATIONS:       For full consideration submit resume and
                    names/addresses of 3 references to Dr. Paul
                    Bottino, H.J. Patterson Hall, Dept. of Plant
                    Biology, University of Maryland, College
                    Park, MD 20742-7011. Applications will be
                    accepted until September 11, 1996 or until
                    the positions are filled.
 
THE UNIVERSITY OF MARYLAND IS AN EQUAL OPPORTUNITY EMPLOYER.

From owner-acedb@net.bio.net Wed Aug 21 23:00:00 1996
Path: biosci!rutgers!uwm.edu!news.cse.psu.edu!news.ecn.bgu.edu!vixen.cso.uiuc.edu!newsfeed.internetmci.com!in3.uu.net!EU.net!usenet2.news.uk.psi.net!uknet!usenet1.news.uk.psi.net!uknet!uknet!bhamcs!news.ox.ac.uk!is.bbsrc.ac.uk!daresbury!not-for-mail
From: rd@mrc-lmb.cam.ac.uk (Richard Durbin)
Newsgroups: bionet.software.acedb
Subject: acedb data updates for C.elegans
Date: 22 Aug 1996 12:28:57 +0100
Lines: 113
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <4vhg9p$uj@mserv1.dl.ac.uk>
Original-To: acedb_distrib@ppsw.cam.ac.uk


This is a broadcast message to the ACEDB mailing list and related
newsgroups.  If you are on the explicit mailing list and do not want
to be, please send email to rd@sanger.ac.uk.

ACEDB data updates WG1.4-5 and WS1.4-13 to 4-16 for C. elegans
==============================================================

You should be using these in conjunction with release 4_3 of the acedb
software.

Reminder: there are now two versions of the C.elegans database.  The
WS1 update series contains everything, whereas WG1 update series
contains all data except sequences and directly related material
(proteins, motifs etc.), for those with limited resources. 

The additions since WG1.4-4 and WS1.4-12 are:

for both types of update

  - a physical map update with a few changes (Aug 9th)
  - some cgc references have been added (2411 onwards) also
	more connections between references and Loci
  - CGC strains (July 18th)
  - worm meeting 1996 citations, abstracts and cross-references
    (ecwm for east coast, euwm for europe, mwwm for mid-west
	wcwm for west coast abstracts respectively)
  - some more Tc1 insertion site positions on sequenced cosmids
  
and for just the complete database including sequences (WS1.4-16)

  Data fom St Louis and Sanger Sequence databases taken in mid-August:
  - There are now 1586 (1464 before) cosmids totalling 47,908,858
        (44,150,616 before) bases.
  - We are switching from using the PIR protein database for homology 
	searches to the TREMBL database, hence many PIR homologies are 
	being deleted and TR ones added.
  - new worm sequences from EMBL release 47 (June 1996)
	   
The total database sizes after adding these updates are around 390Mb
for the WS1 database (we said it would grow!) and around 65Mb for the
WG1 database.

It will take a long time to read in the WS1 updates, particularly
4-15.  All four updates took us several hours.

APOLOGIES
=========

- a set of transgenic strains from David Baillie was added to the
last set of updates but the http URL address has not become visible.
We are trying to put this right. Meanwhile his address for those
interested is http//:darwin.mbb.sfu.ca/imbb/dbaillie/cosmid.html .

Instructions for obtaining updates/the whole thing
==================================================

All the files are available in the following public access accounts
(anonymous ftp sites) accessible over internet:

  ncbi.nlm.nih.gov (130.14.20.1) in the USA, in repository/acedb
  ftp.sanger.ac.uk (193.60.84.11) in England, in pub/acedb
  lirmm.lirmm.fr (193.49.104.10) in France, in directory genome/acedb

In each case, log in as user "anonymous" and give a user identifier
as password.  Remember to transfer the files in BINARY mode by
typing the word "binary" at the start of your ftp session.  Many
thanks to NCBI for letting us share in their excellent resource.

Example:

ftp ncbi.nlm.nih.gov
login: anonymous
password: your user id or email address
cd repository/acedb             # change to relevant directoy
binary				# IMPORTANT
dir				# display files in this directory
get README
get NOTES
get INSTALL
cd ace4				# change to ace4 directory
get bin.sunos.4_3.tar.Z		# get program
cd ../celegans			# change to worm data directory
mget update.WS1.*		# get all WS1 update files
quit

--------------------------------

Get any update files that you do not have already and read the file
NOTES before proceeding further.

Always get a copy of the INSTALL script.  Move it and the .tar.Z files
into the home directory in which you are installing ACEDB.  Type
"source INSTALL".  Start acedb (normally by typing "acedb"), click
"Yes" to accept initialising the database if starting from scratch,
then choose "Add Update File" from the menu (right button), and press
"All updates" with the left mouse button.

If you have a problem making the program work, look at the section
on problems in NOTES, and if that fails to help, let us know.

******************************************************************

Comments about the data should be sent to the data curator, Sylvia
Martinelli (sylvia@sanger.ac.uk).

Comments about the program, or the installation procedure, should be
sent to one of us:

Richard Durbin (rd@sanger.ac.uk)
Jean Thierry-Mieg (mieg@kaa.cnrs-mop.fr)

-------------------- end of message --------------------

From owner-acedb@net.bio.net Wed Aug 28 23:00:00 1996
Path: biosci!daresbury!not-for-mail
From: rd@mrc-lmb.cam.ac.uk (Richard Durbin)
Newsgroups: bionet.software.acedb
Subject: Macace versions of latest C.elegans acedb
Date: 30 Aug 1996 00:36:21 +0100
Lines: 25
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <5059hl$j78@mserv1.dl.ac.uk>
Original-To: acedb_distrib@ppsw.cam.ac.uk


Macintosh versions of the most recent C.elegans acedb release are 
now available as self-extracting archives from the following two
locations:

  ftp://ftp.sanger.ac.uk/pub/acedb/macace
  ftp://ncbi.nih.gov/repository/acedb/macace

These directories contain macace.WS1.4-16.sea.bin (the version with
sequences) and macace.WG1.4-5.sea.bin (the version without).  

The WS1 version is now 136Mb compressed and 440Mb uncompressed, much
bigger than before.  The main reasons are that there is much more
sequence annotation now, and it actually contains the sequence.  The
DNA sequence itself was ommitted accidentally from the 4-8 macace
version!  This explains the dashes seen when trying to look at
sequence in macace.WS1.4-8.  Many apologies.

Please read the README files in the macace directories for further
information on macace.  Further information about the latest data
release was in the release email message for the Unix version,
available from the file acedb/celegans/letter.aug96 in the ftp
directories.

Richard Durbin

From owner-acedb@net.bio.net Sat Aug 31 23:00:00 1996
Path: biosci!internet!biosci!not-for-mail
From: biohelp (BIOSCI Administrator)
Newsgroups: bionet.software.acedb
Subject: BIOSCI/bionet miniFAQ & Fundraiser
Date: 1 Sep 1996 02:00:10 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 239
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <199609010900.CAA01378@net.bio.net>
NNTP-Posting-Host: net.bio.net

(LAST REVISION: 30-JUL-95)

This BIOSCI "miniFAQ" is designed to answer the questions that come up
the *most frequently*.  The main BIOSCI FAQ (Frequently Asked
Questions) is accessible on the World Wide Web at URL
http://www.bio.net/.

If you can not find an answer to your question in this or other
documentation, the BIOSCI technical support staff answers e-mail
queries sent to

		       biosci-help@net.bio.net

We can only answer questions about the use of the newsgroups and
mailing lists.  We unfortunately do not have the staff to do Internet
information searches or answer scientific questions.  Please post
those to the appropriate BIOSCI/bionet newsgroups.


	Contents:
	--------
	0) BIOSCI NEEDS YOUR SUPPORT!!

	1) Using the WWW to access the BIOSCI/bionet newsgroups.

	2) What to do about "spams," i.e., junk mail, ads, etc.

	3) Examples of subscribing and unsubscribing to the mailing lists.

	4) The BIOSCI user address and research interest directory.


0) BIOSCI NEEDS YOUR SUPPORT!!
------------------------------
BIOSCI's government funding has been expended, and we are now
operating solely from advertising revenue that we have raised from our
Web site at http://www.bio.net/.  We need just a few minutes of your
time to help us serve you.

You can do two important things which will take very little time for
you individually and will immensely help us continue to help you.

First, please use our WWW system at http://www.bio.net/ to access the
archives.  You can post or reply to messages via your Web browser as
described in item #1 below.  Your usage helps attract sponsors. If you
contact any of our sponsors, please be sure to thank them for
supporting BIOSCI. It is critical for them to get this feedback if
they are to continue their sponsorship for the long term.

Second, if you work for a company or organization that provides
products or services of interest to the biology community, please pass
this message on to your marketing or marketing communications
department or other appropriate group.  Please ask them to help
support BIOSCI by sponsoring our Web site and explain the uses and
benefits of the system to the biology community. If they are
interested, they can then contact us for further information at our
tech support address, biosci-help@net.bio.net.


1) Using the WWW to access the BIOSCI/bionet newsgroups.
--------------------------------------------------------
As of 10 December 1995, all BIOSCI/bionet full newsgroups are
accessible through the World Wide Web (WWW) at URL http://www.bio.net.
One can read and reply publicly or privately to both recent postings
and archived messages through one's Web browser if it is configured
properly to send e-mail.  Each newsgroup is equipped with its own WAIS
index.  The main BIOSCI home page also has access to the BIO-JOURNALS
Table of Contents database WAIS index and the BIOSCI user address
database described in another item further below.


2) What to do about "spams," i.e., junk mail, ads, etc.
-------------------------------------------------------
BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups),
mailing lists, and a hypermail archive at URL http://www.bio.net/.
The same postings are distributed on all media (except for a small
number of mailing-list-only groups at net.bio.net).  Unfortunately it
is becoming a despicable practice on the Internet (by a few people out
to make a fast buck) to do automated mass postings to thousands of
newsgroups and mailing lists.  These attempts to grab free advertising
are refered to as "spams" in the usual, somewhat boneheaded, net
terminology.  USENET is more susceptible to this practice, and many
spams originate on the USENET groups and then are passed on to the
mailing lists.  However, spammers also get lists of mailing addresses
and hit these too, so neither medium is immune.

What should you do personally if you get junk mail?
---------------------------------------------------
Just delete it and move on without reading it further.  Filing a
protest is becoming increasingly useless because spammers are often
disguising the addresses where the messages are sent from.  Unless you
really understand Internet mail systems, your attempt at protest by
sending replies to the message will often end up being sent to the
address of an innocent person that the spammer is victimizing.

What can BIOSCI/bionet do to protect its newsgroups?
----------------------------------------------------
The only solution currently available is to moderate the newsgroup.
If this newsgroup is already moderated, then you are in good shape.
Moderation protects the USENET distribution from about 95% of the
spams that are being sent to date and protects the mailing lists
completely.  Moderation means, however, that someone has to take the
time to review each message before it goes out.  We have set up
software here that simply allows the moderator to forward to an
address at net.bio.net messages that (s)he wishes to have distributed.
This takes no more time than that needed to read the message and pass
it on, say about 1 min. per message.

Most newsgroups currently have a discussion leader who is responsible
for their newsgroup.  The discussions leaders and their e-mail
addresses are listed in the BIOSCI Information Sheet which is
available on the Web at http://www.bio.net/.  If a newsgroup is being
hit with too many junk postings, please contact the discussion leader
for that group and see if there is interest in moderating the group.
Please do not assume that by simply posting a complaint to the
newsgroup itself, anyone on the BIOSCI staff will act on your
complaint.  With close to 100 newsgroups to run, the BIOSCI staff has
to rely on the discussion leaders of each newsgroup to report problems
directly to us at biosci-help@net.bio.net.

We will moderate any of our newsgroups if the discussion leader tells
us that the readership of the group wishes to do so and if a moderator
is willing to do the work.  For most BIOSCI/bionet groups, this
entails only a few minutes of work each day.

Moderating a newsgroup will resolve probably 95% of the junk postings
on the USENET distribution.  Unfortunately there are easy ways for
determined spammers to override the moderation mechanism on USENET,
but we can protect our e-mail subscribers from unwanted postings if
the newsgroup is moderated.  You can also access our newsgroups over
the WWW at URL http://www.bio.net.  While this Web interface will not
stop spammers from trying to post to the groups, this will give you
yet another way, besides using USENET news, to keep the junk out of
your personal mail files.  For those of you with local USENET news
systems, the Web interface will also give you faster access to new
newsgroups and recent postings.


3) Examples of subscribing and unsubscribing to the mailing lists.
------------------------------------------------------------------
PLEASE NOTE: The BIOSCI management does NOT act on
subscription/unsubscription requests that are posted improperly to the
newsgroups and mailing lists.  People who do this only bother everyone
on the lists to no avail.  Please be sure to follow the proper
procedures below.

Gory details are in the BIOSCI Information sheets on the Web at
http://www.bio.net.  Below we give an example utilizing the
METHODS-AND-REAGENTS list at both of our two BIOSCI sites:

Users in the Americas and Pacific Rim countries who use the BIOSCI
------------------------------------------------------------------
node at computer net.bio.net:
----------------------------

A) Determine the "listname" which is the <=8 character mail address
                                         ^^^^^^^^^^^^^
   for the group.  These can be found in the BIOSCI Info. Sheet.  For
   the METHODS-AND-REAGENTS group the mailing address is
   methods@net.bio.net.  The listname is the portion of the address to
   the left of the @ sign, i.e., "methods".  The listname is used with
   the "subscribe" and "unsubscribe" commands illustrated below.

B) Mail all commands in the body of a mail message addressed to
   biosci-server@net.bio.net.  Do NOT send commands to the newsgroup
   posting addresses!  Leave the Subject: line blank, any text on it
   will be ignored.

C) In the body of your message put one or more of the following
   commands with an "end" command on the last line, e.g.,

   subscribe methods
   unsubscribe methods
   end

   Do NOT put your e-mail address or other text on these lines.  The
   server only allows you to cancel your subscription if the address
   on your mail header matches the address on our mailing list.
   Please ask for help at biosci-help@net.bio.net if your address has
   changed, e.g., if you know you are on the list but the server tells
   you that you are not a member.


Users in Europe, Africa, and Central Asia who use the BIOSCI node at
--------------------------------------------------------------------
computer daresbury.ac.uk (also known as dl.ac.uk):
-------------------------------------------------

To subscribe and unsubscribe to/from the BIOSCI lists, you need to
specify the full USENET newsgroup name with "bionet-news." prepended.
The USENET newsgroup names are listed in the BIOSCI Information sheet
on the Web at http://www.bio.net/.  For the METHODS-AND-REAGENTS list
the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the
appropriate commands are

    sub bionet-news.bionet.molbio.methds-reagnts

    unsub bionet-news.bionet.molbio.methds-reagnts

These commands are included in a message addressed to mxt@dl.ac.uk,
NOT to the newsgroup mailing addresses.  As usual, include the text in
the body of the message as text on the Subject: line is ignored.

To unsubscribe from all the lists at the UK node, use

    unsub bionet-news

Please note that if the address in the list is different than the one
in your mail message header, you will not be able to unsubscribe by
this method. If you have problems, please mail biosci@daresbury.ac.uk.


4) The BIOSCI user address and research interest directory.
-----------------------------------------------------------
Please take this opportunity to add your name, address, and research
interest information to the BIOSCI User Address Database if you have
not already done so.

You can fill out the address form directly through our Web page at URL
http://www.bio.net/adrform.html.

The address database is reindexed nightly for WWW access (the URL is
http://www.bio.net/).  If you are not directly on the Internet but can
reach it by e-mail, please use our waismail server to access the user
directory.  waismail use is described above.  You can also request a
user address form by e-mail from biosci-help@net.bio.net.

Please check your database entry from time-to-time to see if your
address information is still up-to-date.  Because of our limited
personnel resources, we ask that you resubmit a *complete* form to
revise your entry; we only replace complete entries and do not have
resources to edit old forms.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				biosci-help@net.bio.net

