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From: Jamie Kincaid <jamie@thale.life.nottingham.ac.uk>
Newsgroups: bionet.software.acedb
Subject: Viewing DNA alignments in webace
Organization: ACS, The University of Nottingham
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Hello,
In webace when you are viewing a sequence with homologies there is a very
nice feature 'Show homology table / DNA alignments' which shows sequence
matches by base pair whereby orange indicates match, and blue mismatch.

However I notice it doesn't do gapped alignments. Is there a software fix
or an option for doing this?
Alternatively is there another way (perhaps using AceBrowser) where you 
can view alignments at the base pair level and include gaps.

Regards,

Jamie
_______________________________________________________________________________

Jamie Kincaid 
Nottingham Arabidopsis Stock Centre (NASC)
School of Biological Sciences
University of Nottingham, Nottingham, NG7 2RD 

Phone: 0115 951 3091
Fax: 0115 951 3297

NASC website:	nasc.nott.ac.uk




From owner-acedb@hgmp.mrc.ac.uk  Mon Apr 10 15:01:00 2000
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From: Ed Griffiths <edgrif@sanger.ac.uk>
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Here at the Sanger Centre I have started a monthly newsletter in an attempt to
better communicate what's happening to acedb month by month. The basic idea is
to say "this month we added blah, blah to fmap, XXXX to the windows version" and
so on.

Although the newsletter is slightly biased towards Sanger users I thought that
people here might like to see it.

You can either view them at:

http://www.acedb.org/winfo/Newsletters/

or I can add you to my mailing list to receive a plain text version of the
newsletters.

cheers Ed

 ------------------------------------------------------------------------------
| Ed Griffiths, Informatics Group,                                             |
|               The Sanger Centre, Wellcome Trust Genome Campus,               |
|               Hinxton, Cambridge CB10 1SA, UK                                |
|                                                                              |
| email: edgrif@sanger.ac.uk      URL: http://www.sanger.ac.uk/Users/edgrif    |
|   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223 494919        |
 ------------------------------------------------------------------------------




From owner-acedb@hgmp.mrc.ac.uk  Mon Apr 10 15:30:32 2000
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To: bionet-software-acedb@hgmp.mrc.ac.uk
From: dsmith@ucsd.edu (Doug Smith)
Newsgroups: bionet.software.acedb
Subject: xace 4.7 Protein Display
Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre
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I note that the xace 4.7 Protein Display has a seqFeature type of column.
I presume this can be used for coordinate info on motifs and the like.

We are interested in such annotation for protein displays in DictyDB.

Is anyone doing this sort of thing in their ACEDB databases?
If so, could someone point to a few specific protein objects in
an ACEDB database that they have whereby they do this?

Even better, could you send me as an email attachment
a couple of .ace pieces of data for such Protein objects
and for the View object for the Protein class?

Thanks so much
  -Doug

-----------------------------------------------------------------
Douglas W. Smith
Professor of Biology                     UCSD Phone: 858-534-2620
Department of Biology, 0116              UCSD FAX:   858-534-7108
UCSD                                      Home FAX:   858-4573686
La Jolla, CA  92093-0116                  email:  dsmith@ucsd.edu
Home Page:  http://www.biology.ucsd.edu/others/dsmith/dnasys.html


---




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 13 09:39:36 2000
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From: matthews@greengenes.cit.cornell.edu (Dave Matthews)
Newsgroups: bionet.software.acedb
Subject: case-sensitivity of Keywords
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Is it possible to make the ?Keyword class non-Case-Sensitive?  It appears
to be a System class and not controlled by wspec/options.wrm.  I don't
see any way to turn the case-sensitivity off.  (in ace4_7m or 4_8c)
- Dave
---




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 13 09:41:00 2000
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To: bionet-software-acedb@cs.washington.edu
From: Carson Thoreen <Carson_Thoreen@brown.edu>
Newsgroups: bionet.software.acedb
Subject: compiling ace for Mac OSX
Organization: Dept. of Molecular Biotechnology
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Hello --
Has anyone had any luck compiling aceserver for Mac OS X (~Nextstep)?
There aren't any Xlibs, but I don't think that aceserver needs them.
Anyone with ideas, please send them my way!

Carson Thoreen
Carson_Thoreen@brown.edu




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 13 13:33:29 2000
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To: bionet-software-acedb@hgmp.mrc.ac.uk
From: Ed Griffiths <edgrif@sanger.ac.uk>
Newsgroups: bionet.software.acedb
Subject: Re: compiling ace for Mac OSX
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> Has anyone had any luck compiling aceserver for Mac OS X (~Nextstep)?
> There aren't any Xlibs, but I don't think that aceserver needs them.
> Anyone with ideas, please send them my way!

We haven't tried this but I think you will have the best chance with saceserver
(the socket server) rather than aceserver (the RPC server). saceserver uses
straight TCP sockets and has already been compiled in one go on Windows. I'm not
sure what your compilation environment is on Mac OS X, contact me direct if you
like and we can see if between us we can get it running.

cheers Ed

 ------------------------------------------------------------------------------
| Ed Griffiths, Informatics Group,                                             |
|               The Sanger Centre, Wellcome Trust Genome Campus,               |
|               Hinxton, Cambridge CB10 1SA, UK                                |
|                                                                              |
| email: edgrif@sanger.ac.uk      URL: http://www.sanger.ac.uk/Users/edgrif    |
|   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223 494919        |
 ------------------------------------------------------------------------------




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 13 13:34:22 2000
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From: mieg@beta.crbm.cnrs-mop.fr (Danielle et jean Thierry-Mieg)
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Subject: mac OS X
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if this is a posix system you can try

setenv ACEDB_MACHINE POSIX_4
make tace aceserver

but aceserver uses rpc

it would also be interesting to test the beta version of acedb.4_8 available at sanger
which comes with GTK libraries and see if that compiles on you mac

may be srk can discuss that with you
---




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 13 13:34:28 2000
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To: bionet-software-acedb@hgmp.mrc.ac.uk
From: srk@sanger.ac.uk (Simon Kelley)
Newsgroups: bionet.software.acedb
Subject: Re: mac OS X
Organization: Sanger Centre, Hinxton Hall, England.
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Danielle et jean Thierry-Mieg wrote:
> 
> if this is a posix system you can try
> 
> setenv ACEDB_MACHINE POSIX_4
> make tace aceserver
> 
> but aceserver uses rpc
> 
> it would also be interesting to test the beta version of acedb.4_8 available at sanger
> which comes with GTK libraries and see if that compiles on you mac
> 
> may be srk can discuss that with you

It won't unless you can find or do a port of GTK/GDK to the mac, or find
an Xserver for MacOS X. I believe Joen Carmack is porting XFree86, but I
don't know the details.

It would be interesting to know if the non-graphical code works......

Simon
-- 
-------------------------------------------------------------------------------
Simon Kelley.  srk@sanger.ac.uk  simon.kelley@bigfoot.com  +44 1223
494991
---




From owner-acedb@hgmp.mrc.ac.uk  Mon Apr 17 09:22:20 2000
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To: bionet-software-acedb@cs.washington.edu
From: Carson Thoreen <Carson_Thoreen@brown.edu>
Newsgroups: bionet.software.acedb
Subject: Re: mac OS X
Organization: Dept. of Molecular Biotechnology
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>
>
> It won't unless you can find or do a port of GTK/GDK to the mac, or find
> an Xserver for MacOS X. I believe Joen Carmack is porting XFree86, but I
> don't know the details.
>
> It would be interesting to know if the non-graphical code works......
>
> Simon

I can run the client on an alpha, so all that needs to work is saceserver and tace (for
AcePerl). Given that OS X runs on top of a BDS layer, I think it should be possible, and
maybe even trivial, to get it working but I don't know quite where to begin. Ideas?

-Carson




From owner-acedb@hgmp.mrc.ac.uk  Mon Apr 17 09:23:17 2000
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> Is it possible to make the ?Keyword class non-Case-Sensitive?  It appears
> to be a System class and not controlled by wspec/options.wrm.  I don't
> see any way to turn the case-sensitivity off.  (in ace4_7m or 4_8c)
> - Dave

I can see the point here, but I can't advise making this change except
protected by #ifdef ACEDB5 (i.e. only for the next major version),
because otherwise all existing databases with case-dependent keywords
would be in a confused state.

Does anyone remember why we made this case sensitive?

Richard




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   I have been trying out the new socket server and the text client.
Seems work fine for my setup. But how about the graphic client, Unix
and/or Windows; what's new on that (Simon...?) And how will AcePerl fit
into all of this, can we expect a new release that uses the socket
server?

                  Mummi


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From owner-acedb@hgmp.mrc.ac.uk  Tue Apr 18 10:32:44 2000
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From: matthews@greengenes.cit.cornell.edu (Dave Matthews)
Newsgroups: bionet.software.acedb
Subject: performance problems in loading
Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre
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Apologies for forwarding a raw dialog, but there are several interesting
issues scattered in it.  ZmDB is at www.zmdb.iastate.edu/.
- Dave

~~~~~~~~~~~~~
Date: Mon, 17 Apr 2000 14:37:51 -0500
From: xgai <xgai@iastate.edu>
Subject: Re: slow loading ACEDB

Dear Dr. Matthews:

Thank you for your quick response.

I checked the memory usage and xace uses only 8% of the memory. Our server 
has 0.5 GB memory. As you noticed, the Sequence model that I built is a 
very simple model, it is much less complicated than the model used by 
ACeDB. I actually wondered how people who maintain the ACeDB did to load 
the large amount of data. Their database is much larger and much more 
complicated.

I tried to divide the big .ace file into several smaller files. I tried to 
load the database by phases and quit, save the data and reopen it in 
between. It does not solve the problem. The total number of the sequence 
objects seems to be the magical number. I realized that it should take 
longer and longer to update the index file when the index got much larger. 
However, it is the precipitous drop of performance that puzzles me.

In fact, this time the sequences that I am trying to load do not have "EST" 
as the keyword (I found it is not that useful anyway since all my sequences 
are ESTs).

One more question: Do you know any good ACEDB documents that are more like 
an ACEDB database manager's guide? It has been very frustrating for me to 
try to figure a lot of things out and I can not find such a document for 
reference on all of the acedb links or web sites that I can find.

I am really thankful that you spent time answering my questions. I greatly 
appreciate it.

Best wishes,



At 03:01 PM 4/17/00 -0400, you wrote:
>Hi Xiaowu,
>
>Interesting question.  Looks like a good one for the ACEDB newsgroup.
>Lots of folks are building bigger databases nowadays, and no doubt starting
>to hit performance problems.  I have two thoughts/suggestions:
>
>1. machine
>
>The symptoms sound like you're running out of RAM and starting to use the
>swap space (virtual memory).  This would always slow things down hugely.
>Even worse if your swap space is on the same disk with database/block*wrm
>and/or the .ace file.  You can monitor memory usage while the database is
>loading with "ps" and "vmstat".  I like "top" even better; it's usually
>included with Linux.
>
>I noticed this with GrainGenes when the number of Sequence records went
>past about 30K.  On my old Sparc2 with 64 MB RAM it now takes over two hours
>to load the whole database.  On a newer machine with 1 GB RAM (Intel Solaris)
>it's 4 minutes.
>
>2. ACEDB
>
>One thing ACEDB doesn't handle very well is records that have huge numbers
>of links from them, tens of thousands.  I just looked at the Sequence model
>for the online ZmDB, and it looks like you've cleaned it of XREFs that
>might cause this kind of trouble.  But I notice many of your Sequences have
>Keyword "EST".  The ?Keyword class is usually automatically XREF'd; I don't
>know how to prevent it.  Also, trying to query or browse ZmDB for Keyword
>EST, or 'find Sequence keyword=est', all fail.
>
>Did you look in database/log.wrm for complaints?  As you may know, this one
>is common:
>
>2000-04-14_10:20:10 genome 16041        Class Text, object 93.09 has 
>8729 > 3000 cells.
>  This is just a warning, acedb has no hard limits on the mumber of cells
>  per object, but the performances degrade on very large objects
>  Either, you are cross referencing many entries into a single object,
>  it may not be useful, and you could drop the XREF in the model and get the
>  same info via an occasional query or, continually, via a subclass,
>  or This object is Class:?Text, and you should rather use plain Text in 
> the model
>  or define a controlled vocabulary by giving an explicit list of tags
>  This message is issued once per offending class and per code run
>
>
>I'd be interested to hear if you identify any smoking guns.
>
>cheers,
>- Dave
>
>
> > From xgai@iastate.edu Mon Apr 17 10:56:30 2000
> > Subject: Please help
> >
> > I need your help. Our database, ZmDB, is an ACEDB database. I found an
> > interesting problem with ACEDB that confuses and frustrates me. When I used
> > the Ace parser to load a large .ace file, it first was flying (relatively)
> > and parsed thousands of records in a few minutes. However, after a while ,
> > it seemed reach to a critical point where it becomes terribly slow (about
> > one record per minute). I am very frustrated and puzzled. I can not find
> > anywhere in ACEDB documents that says anything about it? Can you shed some
> > lights on it? Thank you.
> >
> > Some details: we are running ACEDB on a linux box (RedHat5.2). The number
> > of records that I tried to load is about 50,000 of the same type sequence
> > data.

Xiaowu Gai
2104 Molecular Biology Building
Department of Zoology & Genetics
Iowa State University
Ames, IA 50010
Tel: (515)-2940022
---




From owner-acedb@hgmp.mrc.ac.uk  Tue Apr 18 13:08:59 2000
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From: syurman@spatialfocus.com
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My partner and I are using ACEDB to construct photogrammetric database
definitions, and store geographic metadata in general.  We are having
trouble finishing the project because ACEDB has repeatedly come to a
screeching halt in the process of doing a dump.  It then promptly loses
all the input since the previous dump.  We have been using ACEDB for
about a year, and haven't run into this before.

Any suggestions?


Thanks in advance,

Sara


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From owner-acedb@hgmp.mrc.ac.uk  Tue Apr 18 15:20:39 2000
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From: zgudmunt@my-deja.com
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Subject: Re: performance problems in loading
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  I would like to pitch in some information about my own experience with
rather large (from my viewpoint) Ace-dbases. I maintain, among other
things, a local version of the human BAC ends collection. These are
between 700 and 800 thousand sequence objects, each linking back to a
BAC-parent, (just over 400 thousand BACs). The whole thing is taking
almost 2 Gb on disk but did, admittedly, take a while to load from the
500 Mb Acefile.

   My hardware is a 450 MHz PIII with around 500 Mb RAM. When querying
the thing, it performs quite well and only slows down when I do
something silly like querying ALL the Sequence-objects by some of their
tags, so all access-methods (AcePerl mostly) are designed to NOT make
that sort of queries! My way around that sort of problem, like when
looking for a sequence with a particular GenBank-accession, is to make a
model and GenBank_accession-object that links back to the sequence
itself, elimating the need to ask check and every sequence for its
accession. Quite similar to indexing a column in a relational table.
But, this may be old news to veteran Ace-ers :I


   So, I hope this helps with the hardware/performance-discussion. I
will soon expand this setup to incorporate other BAC-data (ePCR,
hybridizations etc) which will increase my cross-reference count great
deal. IŽll keep you posted on how it affects my performancs.


   And one more thing; I came across some documentation on a
benchmarking utility called Aquila. Is that still supported and used? I
had trouble finding the software to download. Can someone help me on
that one? Thanks,


                     Mummi, Iceland




In article <200004180057.UAA06408@greengenes.cit.cornell.edu>,
  matthews@greengenes.cit.cornell.edu (Dave Matthews) wrote:
> Apologies for forwarding a raw dialog, but there are several
interesting
> issues scattered in it.  ZmDB is at www.zmdb.iastate.edu/.
> - Dave
>
> ~~~~~~~~~~~~~
> Date: Mon, 17 Apr 2000 14:37:51 -0500
> From: xgai <xgai@iastate.edu>
> Subject: Re: slow loading ACEDB
>
> Dear Dr. Matthews:
>
> Thank you for your quick response.
>
> I checked the memory usage and xace uses only 8% of the memory. Our
server
> has 0.5 GB memory. As you noticed, the Sequence model that I built is
a
> very simple model, it is much less complicated than the model used by
> ACeDB. I actually wondered how people who maintain the ACeDB did to
load
> the large amount of data. Their database is much larger and much more
> complicated.
>
> I tried to divide the big .ace file into several smaller files. I
tried to
> load the database by phases and quit, save the data and reopen it in
> between. It does not solve the problem. The total number of the
sequence
> objects seems to be the magical number. I realized that it should take
> longer and longer to update the index file when the index got much
larger.
> However, it is the precipitous drop of performance that puzzles me.
>
> In fact, this time the sequences that I am trying to load do not have
"EST"
> as the keyword (I found it is not that useful anyway since all my
sequences
> are ESTs).
>
> One more question: Do you know any good ACEDB documents that are more
like
> an ACEDB database manager's guide? It has been very frustrating for me
to
> try to figure a lot of things out and I can not find such a document
for
> reference on all of the acedb links or web sites that I can find.
>
> I am really thankful that you spent time answering my questions. I
greatly
> appreciate it.
>
> Best wishes,
>
> At 03:01 PM 4/17/00 -0400, you wrote:
> >Hi Xiaowu,
> >
> >Interesting question.  Looks like a good one for the ACEDB newsgroup.
> >Lots of folks are building bigger databases nowadays, and no doubt
starting
> >to hit performance problems.  I have two thoughts/suggestions:
> >
> >1. machine
> >
> >The symptoms sound like you're running out of RAM and starting to use
the
> >swap space (virtual memory).  This would always slow things down
hugely.
> >Even worse if your swap space is on the same disk with
database/block*wrm
> >and/or the .ace file.  You can monitor memory usage while the
database is
> >loading with "ps" and "vmstat".  I like "top" even better; it's
usually
> >included with Linux.
> >
> >I noticed this with GrainGenes when the number of Sequence records
went
> >past about 30K.  On my old Sparc2 with 64 MB RAM it now takes over
two hours
> >to load the whole database.  On a newer machine with 1 GB RAM (Intel
Solaris)
> >it's 4 minutes.
> >
> >2. ACEDB
> >
> >One thing ACEDB doesn't handle very well is records that have huge
numbers
> >of links from them, tens of thousands.  I just looked at the Sequence
model
> >for the online ZmDB, and it looks like you've cleaned it of XREFs
that
> >might cause this kind of trouble.  But I notice many of your
Sequences have
> >Keyword "EST".  The ?Keyword class is usually automatically XREF'd; I
don't
> >know how to prevent it.  Also, trying to query or browse ZmDB for
Keyword
> >EST, or 'find Sequence keyword=est', all fail.
> >
> >Did you look in database/log.wrm for complaints?  As you may know,
this one
> >is common:
> >
> >2000-04-14_10:20:10 genome 16041        Class Text, object 93.09 has
> >8729 > 3000 cells.
> >  This is just a warning, acedb has no hard limits on the mumber of
cells
> >  per object, but the performances degrade on very large objects
> >  Either, you are cross referencing many entries into a single
object,
> >  it may not be useful, and you could drop the XREF in the model and
get the
> >  same info via an occasional query or, continually, via a subclass,
> >  or This object is Class:?Text, and you should rather use plain Text
in
> > the model
> >  or define a controlled vocabulary by giving an explicit list of
tags
> >  This message is issued once per offending class and per code run
> >
> >
> >I'd be interested to hear if you identify any smoking guns.
> >
> >cheers,
> >- Dave
> >
> >
> > > From xgai@iastate.edu Mon Apr 17 10:56:30 2000
> > > Subject: Please help
> > >
> > > I need your help. Our database, ZmDB, is an ACEDB database. I
found an
> > > interesting problem with ACEDB that confuses and frustrates me.
When I used
> > > the Ace parser to load a large .ace file, it first was flying
(relatively)
> > > and parsed thousands of records in a few minutes. However, after a
while ,
> > > it seemed reach to a critical point where it becomes terribly slow
(about
> > > one record per minute). I am very frustrated and puzzled. I can
not find
> > > anywhere in ACEDB documents that says anything about it? Can you
shed some
> > > lights on it? Thank you.
> > >
> > > Some details: we are running ACEDB on a linux box (RedHat5.2). The
number
> > > of records that I tried to load is about 50,000 of the same type
sequence
> > > data.
>
> Xiaowu Gai
> 2104 Molecular Biology Building
> Department of Zoology & Genetics
> Iowa State University
> Ames, IA 50010
> Tel: (515)-2940022
> ---
>
>


Sent via Deja.com http://www.deja.com/
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From: Richard Durbin <rd@sanger.ac.uk>
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To: bionet-software-acedb@moderators.isc.org, zgudmunt@my-deja.com
Subject: Re: performance problems in loading
Newsgroups: bionet.software.acedb
Date: Wed, 19 Apr 2000 10:37:56 +0100 (BST)
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I would guess that Xiaowu Gai's problem is with disk access.  Everything is
very fast while filling up cache, but when the kernel's object cache gets
full objects need writing to disk (which they all will eventually) and if
the disk connection is not good then this will slow things way down.  This
type of behaviour would be typical of any database.

Richard

> From xgai@iastate.edu Mon Apr 17 10:56:30 2000
> Subject: Please help
>
> I need your help. Our database, ZmDB, is an ACEDB database. I found an
> interesting problem with ACEDB that confuses and frustrates me. When I used
> the Ace parser to load a large .ace file, it first was flying (relatively)
> and parsed thousands of records in a few minutes. However, after a while ,
> it seemed reach to a critical point where it becomes terribly slow (about
> one record per minute). I am very frustrated and puzzled. I can not find
> anywhere in ACEDB documents that says anything about it? Can you shed some
> lights on it? Thank you.




From owner-acedb@hgmp.mrc.ac.uk  Wed Apr 19 13:29:36 2000
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You fly while you fill the cache
but then it should stay fast

you describe gioing to 1 record/minute which ius ridiculously slow

so i suppose you have defines a cachesize much larger than you actual memeory and are
swapping 
acedb should not swap

please check wspec/cachesize.wrm , the size declared should be a good
proportion of your real ram

other explanation, as proposed by richard, your database disk is not locally mounted

please what is you architecture, and your disk drive

---




From owner-acedb@hgmp.mrc.ac.uk  Wed Apr 19 15:36:16 2000
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To: bionet-software-acedb@hgmp.mrc.ac.uk
From: Ed Griffiths <edgrif@sanger.ac.uk>
Newsgroups: bionet.software.acedb
Subject: Re: Our dumps are diving
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Sara,

> My partner and I are using ACEDB to construct photogrammetric database
> definitions, and store geographic metadata in general.  We are having
> trouble finishing the project because ACEDB has repeatedly come to a
> screeching halt in the process of doing a dump.  It then promptly loses
> all the input since the previous dump.  We have been using ACEDB for
> about a year, and haven't run into this before.

Please could you send some information about the following:

which version of acedb are you using ?

what machine are you running on ?

how big is your database ?

are there any error messages ?

If you are not sure about how to collect any of this information then mail me
direct.

Thanks Ed

 ------------------------------------------------------------------------------
| Ed Griffiths, Informatics Group,                                             |
|               The Sanger Centre, Wellcome Trust Genome Campus,               |
|               Hinxton, Cambridge CB10 1SA, UK                                |
|                                                                              |
| email: edgrif@sanger.ac.uk      URL: http://www.sanger.ac.uk/Users/edgrif    |
|   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223 494919        |
 ------------------------------------------------------------------------------




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 20 09:19:20 2000
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From: mieg@alpha.crbm.cnrs-mop.fr (Danielle et jean Thierry-Mieg)
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Subject: performances
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my database has 150 thousands sequences, i run it on a linux pc 350 MHz
i load all data in may be 10 minutes 

the index all work via hashing so insertion time is independant of size

what is a real kill is as Dave says XREF to many enties including
  ?Text entries which are all the same


could i have a copy of the models used and a sample of tyhe data file if they all look the
same

for example if you have a chromosoeme with very many balst hits
it can become heavy

what we do in the worm is to split the chromosome in cosmids and each has not so many blast hits

---




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 20 10:03:22 2000
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To: bionet-software-acedb@hgmp.mrc.ac.uk
From: Ed Griffiths <edgrif@sanger.ac.uk>
Newsgroups: bionet.software.acedb
Subject: Re: On new socket client/server
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Mummi,

>    I have been trying out the new socket server and the text client.
> Seems work fine for my setup. But how about the graphic client, Unix
> and/or Windows; what's new on that (Simon...?) And how will AcePerl fit
> into all of this, can we expect a new release that uses the socket
> server?

I am just looking at the graphical client code now as there have been other
requests for it to work with the socket server. I get the feeling that this will
either be a 5 minute job or 5 weeks...watch this space...

AcePerl is currently being changed by its author (Lincoln Stein) so that it will
talk directly to the socket server rather than via the intermediate acedb code
which used to be necessary to handle the RPC stuff. I expect that Lincoln will
post here when this work is done.

cheers Ed

 ------------------------------------------------------------------------------
| Ed Griffiths, Informatics Group,                                             |
|               The Sanger Centre, Wellcome Trust Genome Campus,               |
|               Hinxton, Cambridge CB10 1SA, UK                                |
|                                                                              |
| email: edgrif@sanger.ac.uk      URL: http://www.sanger.ac.uk/Users/edgrif    |
|   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223 494919        |
 ------------------------------------------------------------------------------




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 20 11:36:11 2000
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Several people have asked where they can get new versions of acedb code.

If you go to the acedb ftp site (ftp://ftp.sanger.ac.uk/pub/acedb/) you will
find a tar/gzip file called:

Sanger-release.2000_03_08.tar.gz

this is our last monthly build of the 4_8c development code. The montly builds
are intended to be reasonably stable development code that we get internal users
at the Sanger centre to try out.

You are welcome to try out this code BUT NOTE THE FOLLOWING:

- this is development code, please don't use it on your prized database (unless
you are ready to restore the database yourself). Experiment with a copy !

- interfaces/code behaviour will change from month to month.

- there may be obvious bugs or performance problems which won't be fixed until
the next monthly release

- if you find a problem then do report it to us (either through this newsgroup
or via email, best to email acedb@sanger.ac.uk).

I will be updating the ftp site, especially the README, and will put new monthly
builds on the site as they are done.

cheers Ed

 ------------------------------------------------------------------------------
| Ed Griffiths, Informatics Group,                                             |
|               The Sanger Centre, Wellcome Trust Genome Campus,               |
|               Hinxton, Cambridge CB10 1SA, UK                                |
|                                                                              |
| email: edgrif@sanger.ac.uk      URL: http://www.sanger.ac.uk/Users/edgrif    |
|   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223 494919        |
 ------------------------------------------------------------------------------




From owner-acedb@hgmp.mrc.ac.uk  Thu Apr 20 17:03:55 2000
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Mummi,

>    And one more thing; I came across some documentation on a
> benchmarking utility called Aquila. Is that still supported and used? I
> had trouble finding the software to download. Can someone help me on
> that one? Thanks,

According to the header in the aquila perl script this is the person who wrote
aquila:

 #  Author: Detlef Wolf (D.Wolf@dkfz-heidelberg.de)
 #  Copyright (C) European Data Resource, 1995
 #--------------------------------------------------------------------
 # This file is part of the IGD project

I don't know if there have been any updates sicne 1995, perhaps if D.Wolf
follows this newsgroup they will send in a note.

We use aquila for testing the overnight build of acedb. It can be used to test
the commandline versions of acedb: tace, giface, aceclient. You write script
files of the acedb commands you want to use for testing and aquila squirts these
into stdin and captures acedbs output. You can then use aquila to compare the
output from previous acedb executables with the current one and look for
differences. NOTE that if finds differences, not necessarily errors, it for
instance find any comment output that has changed. Never-the-less it is very
useful for flagging code changes that have broken acedb.

I can tar up our test stuff if this is useful, if you manage to contact the
owner of aquila and find that it has been updated, perhaps you could let me
know.

cheers Ed

 ------------------------------------------------------------------------------
| Ed Griffiths, Informatics Group,                                             |
|               The Sanger Centre, Wellcome Trust Genome Campus,               |
|               Hinxton, Cambridge CB10 1SA, UK                                |
|                                                                              |
| email: edgrif@sanger.ac.uk      URL: http://www.sanger.ac.uk/Users/edgrif    |
|   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223 494919        |
 ------------------------------------------------------------------------------




From owner-acedb@hgmp.mrc.ac.uk  Tue Apr 25 09:30:45 2000
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From: mieg@alpha.crbm.cnrs-mop.fr (Danielle et jean Thierry-Mieg)
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Subject: aquila
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Detlef Wolf, who wrote aquila is now in Swiss working for a bio company

I am taking care of the package
I will put the latest package on the ncbi and sanger site

Aquila can be used to find differences and to compare compilation options
and machine speed

It produces a very large amount of output files but has an excellent facility to
summarize the results

 Detlef.Wolf@Roche.com
is his mail

---




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Hi Ed,

My apologies to all.  The problem turned out to be the documentation I'd
given my colleague.  Our applications are way off the beaten track for
most of the ACEDB stuff, so we tend to do our own documentation.  I'm
responsible for it, and made way too many assumptions.  I'm reworking it
and am sure the problem will solve itself post haste.

Many thanks for such wonderful software.

Cheers,

Sara

> Please could you send some information about the following:
<snip>
--------------------------------------------------------------------
> | Ed Griffiths, Informatics
Group,                                             |
> |               The Sanger Centre, Wellcome Trust Genome
Campus,               |
> |               Hinxton, Cambridge CB10 1SA,
UK                                |
>
|
|
> | email: edgrif@sanger.ac.uk      URL:
http://www.sanger.ac.uk/Users/edgrif    |
> |   Tel: +44-1223-494780 (switch  +44 1223 834244) Fax: +44 1223
494919        |
>
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>
>


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From owner-acedb@hgmp.mrc.ac.uk  Tue Apr 25 09:31:53 2000
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Using AcePerl, I'm trying to add data to an object
created in my script.  The 'add_row' (and 'add_tree')
methods do not appear to be capable of handling a tag
without an associated value (e.g. using the existence
of the tag in the object as a flag.)

Is it possible to add just a tag that has no associated
value in the model using AcePerl? (importing a .ace file
works fine)

Thanks.  Brian
---




From owner-acedb@hgmp.mrc.ac.uk  Wed Apr 26 12:51:50 2000
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jean said:

: Date: Wed, 19 Apr 2000 13:29:34 +0100 (BST)
: 
: You fly while you fill the cache
: but then it should stay fast
: 
: you describe gioing to 1 record/minute which ius ridiculously slow
: 
: so i suppose you have defines a cachesize much larger than you actual 
: memeory and are swapping
: acedb should not swap
: 
: please check wspec/cachesize.wrm , the size declared should be a good
: proportion of your real ram


Xiaowu Gai reported back that the problem was indeed his cache sizes, but
in the opposite direction.  He originally had 
CACHE1 = 4000
CACHE2 = 4000
on a machine with 0.5 GB memory.  (I'm not sure if that's RAM or total.)
The fix:

> I increased the cache sizes to the same as the ones that you listed [16000,
> 32000] and it solved the problem. I loaded the whole 53,000 sequences in 10
> minutes. I also tried to increase them a little more and it became even
> faster.

---




From owner-acedb@hgmp.mrc.ac.uk  Wed Apr 26 15:46:36 2000
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Subject: direction
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this is the direction i proned !

: please check wspec/cachesize.wrm , the size declared should be a good
: proportion of your real ram

to me good propportion means 30% 
---




