From owner-ageing@net.bio.net Mon Nov 02 22:00:00 1992 Path: biosci!parcom.ernet.in!music From: music@parcom.ernet.in (Rajeev Upadhye) Newsgroups: bionet.molbio.ageing Subject: (none) Message-ID: <9211030958.AA14346@parcom> Date: 3 Nov 92 14:08:31 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 27 Sir, I am already a member of the discussion group dedicated to "ageing" on this network. Can you help me to get addresses of the discussion grups dedicated to following topics: a. Psychology, psychiatry b. Cardiology c. Alternative medicine Pl. forward my request to appropriate place if necessary as this is group is the only outlet for me to find out this information. Rajeev Upadhye Email: music@[arcom.ernet.in ..OR.. parcom!music@shakti.ernet.in Postal: Knowledge Based Computing Group Centre for Development of Advanced Computing University Campus Ganesh Khind Pune, Maharashtra, INDIA 411 007 r From owner-ageing@net.bio.net Tue Nov 03 22:00:00 1992 Path: biosci!bcm!cs.utexas.edu!sdd.hp.com!zaphod.mps.ohio-state.edu!caen!spool.mu.edu!olivea!charnel!pkralik From: pkralik@ecst.csuchico.edu (Wintermute) Newsgroups: bionet.molbio.ageing Subject: Free Radical Reactions Summary: article references Keywords: free radical reactions Message-ID: <1d82vjINN6rt@charnel.ecst.csuchico.edu> Date: 4 Nov 92 08:52:03 GMT Organization: California State University, Chico Lines: 16 NNTP-Posting-Host: cscihp.ecst.csuchico.edu Hello! Let me just start by saying that I know *nothing* about anything discussed in this group! My friend, however, is. Therefore I told him I would ask anyone who reads this group the following: I have a report on free radical reactions and was wondering if anyone out in Netland would have any information on this topic or perhaps some leads on sources I could look into to get more info...Thanx in advance! Mike Escobedo -- +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ + Patrick Kralik(a.k.a. WINTERMUTE) pkralik@cscihp.ecst.csuchico.edu + + + + "I've lost my mind, but it's backed up on tape somewhere" + From owner-ageing@net.bio.net Wed Nov 18 22:00:00 1992 Path: biosci!uwm.edu!cs.utexas.edu!usc!usc!not-for-mail From: jdevlin@pollux.usc.edu (Joseph T. Devlin) Newsgroups: bionet.molbio.ageing Subject: Alzheimer's disease Summary: Relating the neuropathology to cognitive deficits Keywords: Alzheimers, cognition, neuropathology Message-ID: <1eh9kkINN8vo@pollux.usc.edu> Date: 19 Nov 92 23:57:08 GMT Organization: University of Southern California, Los Angeles, CA Lines: 24 NNTP-Posting-Host: pollux.usc.edu Hello all, I have been doing some research into the Alzheimer's literature and I characteristicly find a dichotomy between the cognitive deficits of AD and the known neuropathology of the disease. As yet I haven't seen even any suggestions as to how the two might relate. What I am interested in is what the possible implications of amyloid plaque build-up and neurofibrillary tangles might be. I understand that in general noone knows but there must be some suggestions out there. If anyone could point me to appropriate literature I would appreciate it. In addition, if anyone was willing to make off-the-record speculations within this group I would appreciate reading those too. Thank you for your help. - Joe ************************************************************************* Joseph Devlin * email: jdevlin@pollux.usc.edu University of Southern California * Department of Computer science * "The axon doesn't think. Los Angeles, CA 90089 * It just ax." George Bishop ************************************************************************* From owner-ageing@net.bio.net Thu Nov 19 22:00:00 1992 Path: biosci!bcm!cs.utexas.edu!uunet!munnari.oz.au!uniwa!uniwa!nfm From: ibacon@uniwa.uwa.edu.au (Ian Bacon) Newsgroups: bionet.molbio.ageing Subject: Age research in Australia Message-ID: <1eiaj4INN48d@uniwa.uwa.edu.au> Date: 20 Nov 92 09:19:32 GMT Organization: The University of Western Australia Lines: 8 NNTP-Posting-Host: uniwa.uwa.edu.au X-Newsreader: Tin 1.1 PL5 After having read about age research being carried out in the US and elsewhere I have grown curious about age research in Australia. Is anyone doing this research, how is it being treated by the academic establishment? All comments welcome. Ian Bacon From owner-ageing@net.bio.net Fri Nov 20 22:00:00 1992 Path: biosci!news.cs.indiana.edu!sgiblab!swrinde!cs.utexas.edu!uunet!mcsun!sunic!aun.uninett.no!news.uit.no!ibg.uit.no!erikl From: erikl@ibg.uit.no (Erik Lovaas) Newsgroups: bionet.molbio.ageing Subject: Re: Alzheimer's disease Summary: Relating the neuropathology to cognitive deficits Keywords: Alzheimers, cognition, neuropathology Message-ID: Date: 21 Nov 92 05:59:38 GMT References: <1eh9kkINN8vo@pollux.usc.edu> Sender: news@news.uit.no (USENET News System) Organization: UIT Lines: 61 In article <1eh9kkINN8vo@pollux.usc.edu> jdevlin@pollux.usc.edu (Joseph T. Devlin) writes: >Subject: Alzheimer's disease >From: jdevlin@pollux.usc.edu (Joseph T. Devlin) >Date: 19 Nov 92 23:57:08 GMT >Keywords: Alzheimers, cognition, neuropathology >Summary: Relating the neuropathology to cognitive deficits >Hello all, > I have been doing some research into the Alzheimer's >literature and I characteristicly find a dichotomy between >the cognitive deficits of AD and the known neuropathology >of the disease. As yet I haven't seen even any suggestions >as to how the two might relate. Dear Joe: At present there are speculations if Alzheimeres disease somehow relate to oxidative destructions of brain tissue, and if antioxidants may prevent such effects. Some recent litterature is listed: 1. Richardson, J. S., K. V. Subbarao, and L. C. Ang. 1992. On the possible role of iron-induced free radical peroxidation in neural degeneration in Alzheimer's disease. Ann.NY Acad.Sci. 648:326-327. 2. Backon, J. 1991. Dementia in cancer patients undergoing chemotherapy: Implication of free radical injury and relevance to Alzheimer disease. Med.Hypotheses 35:146-147. 3. Evans, P. H., J. Klinowski, and E. Yano. 1991. Cephaloconiosis: A free radical perspective on the proposed particulate-induced etiopathogenesis of Alzheimer's dementia and related disorders. Med.Hypotheses 34:209-219. Notes : By analogy to the etiology of the pneumoconioses, exogenous dust-induced diseases of the lung, and endogenous crystal- induced arthropathies such as gout, it is proposed that Alzheimer's dementia and allied disorders are causally related to the accumulation of fibriform inorganic deposits within the brain. Hence the neonosological term 'Cephaloconiosis'. It is proposed that: 1) either by the extrinsic migration or intrinsic formation and deposition of insoluble and persistent inorganic reactive nidi, the particle- induced generation of tissue-damaging free-radical oxygen metabolites by stimulated brain glial macrophage-type and allied phagocytic cells, provides a rationale for the etiopathogenesis of neurodegenerative processes; 2) the modulation of the injurious oxidative metabolic reaction by micronutrient and pharmacological antioxidant agents is a rational and potentially feasible strategy for future therapeutic clinical investigations. AUTHOR 4. Perrin, R., S. Brianon, C. Jeandel, Y. Artur, A. Minn, F. Penin, and G. Siest. 1990. Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: A case-control study. Gerontology 36:306-313. 5. Subbarao, K. V., J. S. Richardson, and L. C. Ang. 1990. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J.Neurochem. 55:342-345. 6. Volicer, L. and P. B. Crino. 1990. Involvement of free radicals in dementia of the Alzheimer type: A hypothesis. Neurobiol.Aging 11:567-571. Erik Lovaas From owner-ageing@net.bio.net Tue Nov 24 22:00:00 1992 Path: biosci!bcm!cs.utexas.edu!uunet!sftwks!bradbury From: bradbury@sftwks.UUCP (Robert Bradbury) Newsgroups: bionet.molbio.ageing Subject: Re: Alzheimer's disease Summary: Relationship between AD and Parkinson's and Mitochondria Keywords: Alzheimers, Parkinsons, cognition, neuropathology Message-ID: <221@sftwks.UUCP> Date: 24 Nov 92 21:02:06 GMT References: <1eh9kkINN8vo@pollux.usc.edu> Organization: Softworks Ltd, Seattle, WA Lines: 36 In addition to Erik's list of references to AD, one might want to check out: Annals of Neurology (1992) V 32:Supplement - this issue is devoted entirely to free radical involvement in Parkinson's Disease Mutation Research (1992) 275 - this issue is devoted entirely to metabolic failure due to deletions in the mitochondrial genome PD has clearer links between free radical damage and cell death because the metabolism of dopamine results in the production of H2O2. AD on the other hand appears to be a defect in protein processing. One could speculate that a failure in protein processing results in the accumulation of toxic products leading to cell death. Of course high oxygen use causing free radical damage to proteins and the lower levels of defenses found in AD patients may help to accelerate the accumulation of proteins which are not properly recycled. All of this is compounded by the fact that we are slowly losing our mitochondrial genome. Cells which consume large amounts of oxygen and have poor defenses against free radicals (neurons) are likely to suffer an increased rate of deletions to the mitochondrial genome leading to energy insufficiency and eventual cell death. My feelings currently are that both AD and PD are probably a genetic defect which interferes with the ability of particular cells to deal with the damages caused by free radicals associated with their individual biochemical environments. -- Robert Bradbury uunet!sftwks!bradbury Death is an imposition on the human race, and no longer acceptable Alan Harrington, The Immortalist (1969) From owner-ageing@net.bio.net Tue Nov 24 22:00:00 1992 Path: biosci!uwm.edu!zaphod.mps.ohio-state.edu!caen!uunet!utcsri!torn!watserv2.uwaterloo.ca!sciborg.uwaterloo.ca!lshi From: lshi@sciborg.uwaterloo.ca (lshi) Newsgroups: bionet.molbio.ageing,bionet.molbio.gene-linkage Subject: help Message-ID: Date: 25 Nov 92 20:33:09 GMT Sender: news@watserv2.uwaterloo.ca Distribution: na Organization: University of Waterloo Lines: 22 Xref: biosci bionet.molbio.ageing:359 bionet.molbio.gene-linkage:131 Originator: lshi@sciborg.uwaterloo.ca From lshi@biology.watstar.uwaterloo.ca Wed Nov 25 15:26:18 1992 Received: from steam.uwaterloo.ca by sciborg.uwaterloo.ca with SMTP id ; Wed, 25 Nov 92 15:26:17 -0500 Received: from sail.uwaterloo.ca by steam.uwaterloo.ca with SMTP id ; Wed, 25 Nov 92 15:26:21 -0500 Received: by sail.uwaterloo.ca (5.57/SMI-3.0DEV3) id AA16055; Wed, 25 Nov 92 15:26:20 -0500 Message-Id: <9211252026.AA16055@sail.uwaterloo.ca> From: lshi@biology.watstar To: lshi@sciborg Date: Wed, 25 Nov 1992 15:25:20 EST Status: OR Dear Netter, I am a student majoring in gerontology. I am now doing some literature work related to the molecular genetic part of research of Alzheimer's disease. Since I am not familiar with molecular genetics, I wonder if there is someone out there can help me to get the information of this? Please reply to this account. Thanks in advance. From owner-ageing@net.bio.net Wed Nov 25 22:00:00 1992 Path: biosci!agate!spool.mu.edu!uunet!utcsri!torn!news.ccs.queensu.ca!qucdn!promislo From: PROMISLO@QUCDN.QueensU.CA Newsgroups: bionet.population-bio,bionet.molbio.ageing Subject: age-specific sex-biased mortality Message-ID: <92331.102959PROMISLO@QUCDN.QueensU.CA> Date: 26 Nov 92 15:29:58 GMT Organization: Queen's University at Kingston Lines: 14 Xref: biosci bionet.population-bio:351 bionet.molbio.ageing:360 I'm looking for work on changes with age in the degree of sex-biased mortality in human populations. I am aware of such theoretical work as Vaupel and Yashin, 1985, Amer. Statist. 39:176-185 that may be relevant. Does anyone know of medical literature that might be appropriate to look at? A more general theme that might exist in the medical literature, as well as literature on measuring selection in natural populations, is the effect of cohort heterogeneity on measures of survival. I have just started looking at this problem, and a few good references would be most helpful to me. Any thoughts? Daniel Promislow