From owner-ageing@net.bio.net Fri Sep 03 23:00:00 1993 Path: biosci!FDACFSAN.BITNET!FOF From: FOF@FDACFSAN.BITNET Newsgroups: bionet.molbio.ageing Subject: DHEA/deprenyl effects on aging. Message-ID: <9309040506.AA22375@net.bio.net> Date: 4 Sep 93 00:25:23 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 6 I have a general pharmacologic question. Does anyone know anything about the effects of dehydroepiandrosterone (DHEA- an adrenal steroid hormone) or deprenyl (an irreversible inhibitor of monoamine oxidase (MAO) B on aging. From published articles I gather that DHEA has been touted as a substance that reverses the aging phenotype. Deprenyl is reported in several studies to allow a 50% increase in the lifespan of rats. Any info will be appreciated. From owner-ageing@net.bio.net Sat Sep 04 23:00:00 1993 Path: biosci!WATSON.IBM.COM!cliff From: cliff@WATSON.IBM.COM ("Cliff Pickover ", 914 945-3630) Newsgroups: bionet.molbio.ageing Subject: Looking for Contributors Message-ID: <9309051215.AA20357@net.bio.net> Date: 5 Sep 93 12:15:39 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 26 You are hereby cordially invited to submit a manuscript for a volume titled The Future of Computers in Medicine edited by Clifford A. Pickover. The book will include speculative, informed essays on the future use of computers in surgery, diagnosis, medical imaging, health care, epidemiology, artificial life, cancer and other simulations, virtual reality, robotic surgery, education, and more. All contributions will be refereed. Highest chance of acceptance will be given to papers with the highest quality of English writing, illustrations, and content. If you are interested, please send a tentative title, short abstract of your proposed chapter, and your name and address (hardcopy and e-mail) to cliff@watson.ibm.com. Abstracts are due by September 20th. Completed papers are due by January, 31 1994. I am looking for self-contained, comprehensive papers focussing on novel topics of a broader nature than is usually found in research papers. The intended audiences are educated laypeople as well as technical readers. Please send a note to cliff@watson.ibm.com for submission guidelines. From owner-ageing@net.bio.net Mon Sep 06 23:00:00 1993 Path: biosci!rutgers!mcclb0!cmcl2!yale.edu!newsserver.jvnc.net!howland.reston.ans.net!math.ohio-state.edu!cs.utexas.edu!uunet!munnari.oz.au!uniwa!newsman!vetmac3.csu.murdoch.edu.au!cummins From: cummins@possum.murdoch.edu.au (Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Re: DHEA/deprenyl effects on aging. Message-ID: <26j1t5INNdgo@newsman.csu.murdoch.edu.au> Date: 7 Sep 93 22:27:49 GMT References: <9309040506.AA22375@net.bio.net> Organization: Murdoch University Lines: 6 NNTP-Posting-Host: vetmac3.csu.murdoch.edu.au X-UserAgent: Nuntius v1.1.1d24 X-XXMessage-ID: X-XXDate: Tue, 7 Sep 93 06:29:25 GMT DHEA/deprenyl effects on aging. DHEA inhibits a number of enzymes implicated in the general control of the levels of oxidative stress. These include monoamine oxidase and glucose-6-phosphate dehydrogenase. Why inhibition of these enzymes should slow aging (assuming it does) beats me. Maybe it!s just to do with slowing down metabolic rate? From owner-ageing@net.bio.net Wed Sep 08 23:00:00 1993 Path: biosci!daresbury!daresbury!news From: CS@at.ac.univie.abc ("Christoph Schller") Newsgroups: bionet.molbio.ageing Subject: Catalase; SOD Message-ID: <1993Sep9.151124.8214@gserv1.dl.ac.uk> Date: 9 Sep 93 17:10:36 GMT Sender: list-admin@daresbury.ac.uk Distribution: bionet Lines: 9 Precedence: first-class Original-To: ageing@uk.ac.daresbury Priority: normal X-Mailer: Pegasus Mail v2.3 (R5). Hi Netters I am working with the Saccharomyces Catalase genes. Till now I did only transcriptional regulation studies but I am also interested in the physiological function of this enzymes. Deletion of all catalase genes in S.c. gives no phenotype (at least under lab conditions). My question is: Is catalase an important enzyme in any biological system? Under which conditions and in what context is Catalase important? Thank you very much. From owner-ageing@net.bio.net Thu Sep 09 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!usc!cs.utexas.edu!swrinde!network.ucsd.edu!sdcc12!sdcc3!dclopton From: dclopton@sdcc3.ucsd.edu (David Clopton) Newsgroups: bionet.molbio.ageing Subject: Re: Catalase; SOD Message-ID: <54258@sdcc12.ucsd.edu> Date: 9 Sep 93 23:09:28 GMT References: <1993Sep9.151124.8214@gserv1.dl.ac.uk> Sender: news@sdcc12.ucsd.edu Distribution: bionet Lines: 22 Nntp-Posting-Host: sdcc3.ucsd.edu In <1993Sep9.151124.8214@gserv1.dl.ac.uk> CS@at.ac.univie.abc ("Christoph Schller") writes: >Hi Netters >I am working with the Saccharomyces Catalase genes. Till now I did >only transcriptional regulation studies but I am also interested in >the physiological function of this enzymes. Deletion of all catalase >genes in S.c. gives no phenotype (at least under lab conditions). >My question is: Is catalase an important enzyme in any biological >system? Under which conditions and in what context is Catalase >important? >Thank you very much. Deletion of the catalase gene yielding no phenotype doesn' REALLY surprise me, if you look only at "lab conditions." Catalase is responsible for eliminating hydrogen peroxide by converting it to water and oxygen. Most cells have other enzymes which also contribute to this activity, e.g. glutathione peroxidase (RBC's), and cytochrome c peroxidase (if memory serves me right). So, al long as levels of oxidative stress are very low, there should be no problem. Compare their survival when exposed to hydrogen peroxide, and I expect that you would see the yeast die at much lower concentrations when it doesn't have catalase. From owner-ageing@net.bio.net Thu Sep 09 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!uknet!pipex!uunet!munnari.oz.au!uniwa!newsman!Jim.Cummins From: cummins@possum.murdoch.edu.au (Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Maternal age effects on next generation Message-ID: <26r6gcINNlq8@newsman.csu.murdoch.edu.au> Date: 11 Sep 93 00:35:24 GMT References: <9309040506.AA22375@net.bio.net> <26j1t5INNdgo@newsman.csu.murdoch.edu.au> Sender: -Not-Authenticated-[6523] Lines: 24 NNTP-Posting-Host: vetmac3.csu.murdoch.edu.au X-Posted-From: InterNews 1.0@newsman.csu.murdoch.edu.au. Xdisclaimer: No attempt was made to authenticate the sender's name. Does anyone in the group have any information on the effects of maternal age on aging processes in their progeny? The background to this is that mitochondrial DNA deletions and mutations are now thought to have a strong association with aging and degenerative processes. Mitochondrial DNA is maternally inherited and one source of defective mitochondria might be the eggs of women who reproduce late in life. We know from oocyte donation programs that the fertility of eggs starts to decline when women pass their mid-30s, and possible even as early as 32. Certainly from 35 on there is a dramatic fall in fertility. The age of first birth in W Europe is approaching 30, and for women in infertility programs 50% are over 35 years. The oocyte is in arrested dictyate meiosis from fetal life until shortly before the ovulatory cycle, and it's conceivable that mitochondrial genomic (as well as nuclear genomic) errors can build up. We have started evaluating paternal and maternal age in men with unexplained infertility, as this seems to have a link with mitochondrial disorders. However, I wonder if any other workers in the area have any data? The children of older women need careful evaluation, as mitochondrial disorders can be quite subtle. Jim Cummins School of Veterinary Studies, Murdoch University, Western Australia 6150 From owner-ageing@net.bio.net Fri Sep 10 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!noc.near.net!das-news.harvard.edu!husc-news.harvard.edu!husc.harvard.edu!husc10.harvard.edu!beeson From: beeson@husc10.harvard.edu (Nicholas Beeson) Newsgroups: bionet.molbio.ageing Subject: Proteins involved in DNA transcription Message-ID: <26r9m3$aci@scunix2.harvard.edu> Date: 11 Sep 93 01:29:39 GMT References: <9309051215.AA20357@net.bio.net> Distribution: bionet Organization: Harvard University Science Center Lines: 25 NNTP-Posting-Host: husc10.harvard.edu Re: Proteins involved in DNA transcription. We are looking for collaboration opportunities with molecular biology groups that are involved in the study of proteins involved in the transcription of DNA. I am part of a structural biology group with extensive experience in solving the solution structure of proteins ( using NMR spectroscopy.) ( I am a postdoc in Gerhard Wagner's lab at the Harvard Medical School). A requirement for protein structure determination by NMR is that it is necessary to enrich the proteins with 15N and 13C. Therefore, a high level of expression in a suitable host (e.g. E. Coli ) is essential. If you are working with such a protein, and have the necessary expression system set up and if you are interested in collaboration with a lab that can determine the solution structure of such a protein, please contact me by e-mail at sekhar@heimdall.med.harvard.edu -- Sekhar Talluri sekhar@heimdall.med.harvard.edu From owner-ageing@net.bio.net Sun Sep 12 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!news.ans.net!malgudi.oar.net!chemabs!ljc55 From: ljc55@cas.org (Linda J. Carter) Newsgroups: bionet.molbio.ageing Subject: PCR primers and hybridization probes Keywords: biosequence database PCR primer and hybridization probe Message-ID: <1993Sep13.172553.20268@cas.org> Date: 13 Sep 93 17:25:53 GMT References: <54258@sdcc12.ucsd.edu> Sender: usenet@cas.org Reply-To: ljc55@cas.org Organization: Chemical Abstracts Service Lines: 28 For those of you interested in PCR primers and hybridization probes I would really appreciate your opinions about their inclusion in biosequence databases. Some of my specific concerns are as follows: 1. Do you feel primers and probes tend to clutter up a nucleic acid database and cause unnecessary retrievals when searching for sequences of much longer length? 2. Because primers and probes are usually designed from known sequence information often already in the database, is it still justifiable to include them as additional entries? 3. What applications of primers and probes should justify their inclusion in a biosequence database, e.g. clinical diagnosis, taxonomy, evolution, gene mapping, or methods? 4. If you were to search for primers and probes in a biosequence database what would be most efficient for you? Would some type of descriptive information be helpful, e.g. their application or their origin? Thank you very much for any thoughts you might have on this subject. Please post your response to ljc55@cas.org From owner-ageing@net.bio.net Tue Sep 14 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!darwin.sura.net!RBSE.Mountain.Net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: mwitten@HERMES.CHPC.UTEXAS.EDU Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: CONGRESS: COMPUTATIONAL MEDICINE AND PUBLIC HEALTH (long) Message-ID: <9309141800.AA09141@morpheus.chpc.utexas.edu> Date: 14 Sep 93 18:00:58 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Lines: 554 Xref: biosci bionet.molbio.ageing:480 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: mwitten<@UBVM.CC.BUFFALO.EDU,@UTHERMES.BITNET:mwitten@HERMES.CHPC.UTEXAS.EDU> To: Marshall University Content-transfer-encoding: 7BIT X-To: GERINET@ubvm.bitnet Comments: W: FROM field duplicated. Last occurrence was retained. ** NOTE CHANGES IN SUBMISSION AND REGISTRATION DEADLINES ** FIRST WORLD CONGRESS ON COMPUTATIONAL MEDICINE, PUBLIC HEALTH AND BIOTECHNOLOGY 24-28 April 1994 Hyatt Regency Hotel Austin, Texas ----- (Feel Free To Cross Post This Announcement) ---- 1.0 CONFERENCE OVERVIEW: With increasing frequency, computational sciences are being exploited as a means with which to investigate biomedical processes at all levels of complexity; from molecular to systemic to demographic. Computational instruments are now used, not only as exploratory tools but also as diagnostic and prognostic tools. The appearance of high performance computing environments has, to a great extent, removed the problem of increasing the biological reality of the mathematical models. For the first time in the history of the field, practical biological reality is finally within the grasp of the biomedical modeler. Mathematical complexity is no longer as serious an issue as speeds of computation are now of the order necessary to allow extremely large and complex computational models to be analyzed. Large memory machines are now routinely available. Additionally, high speed, efficient, highly optimized numerical algorithms are under constant development. As these algorithms are understood and improved upon, many of them are transferred from software implementation to an implementation in the hardware itself; thereby further enhancing the available computational speed of current hardware. The purpose of this congress is to bring together a transdisciplinary group of researchers in medicine, public health, computer science, mathematics, nursing, veterinary medicine, ecology, allied health, as well as numerous other disciplines, for the purposes of examining the grand challenge problems of the next decades. This will be a definitive meeting in that it will be the first World Congress of its type and will be held as a follow-up to the very well received Workshop On High Performance Computing In The Life Sciences and Medicine held by the University of Texas System Center For High Performance Computing in 1990. Young scientists (graduate students, postdocs, etc.) are encouraged to attend and to present their work in this increasingly interesting discipline. Funding is being solicited from NSF, NIH, DOE, Darpa, EPA, and private foundations, as well as other sources to assist in travel support and in the offsetting of expenses for those unable to attend otherwise. Papers, poster presentations, tutorials, focused topic workshops, birds of a feather groups, demonstrations, and other suggestions are also solicited. 2.0 CONFERENCE SCOPE AND TOPIC AREAS: The Congress has a broad scope. If you are not sure whether or not your subject fits the Congress scope, contact the conference organizers at one of the addresses below. Subject areas include but are not limited to: *Visualization/Sonification --- medical imaging --- molecular visualization as a clinical research tool --- simulation visualization --- microscopy --- visualization as applied to problems arising in computational molecular biology and genetics or other non-traditional disciplines --- telemedicine *Computational Molecular Biology and Genetics --- computational ramifications of clinical needs in the Human Genome, Plant Genome, and Animal Genome Projects --- computational and grand challenge problems in molecular biology and genetics --- algorithms and methodologies --- issues of multiple datatype databases *Computational Pharmacology, Pharmacodynamics, Drug Design *Computational Chemistry as Applied to Clinical Issues *Computational Cell Biology, Physiology, and Metabolism --- Single cell metabolic models (red blood cell) --- Cancer models --- Transport models --- Single cell interaction with external factors models (laser, ultrasound, electrical stimulus) *Computational Physiology and Metabolism --- Renal System --- Cardiovascular dynamics --- Liver function --- Pulmonary dynamics --- Auditory function, coclear dynamics, hearing --- Reproductive modeling: ovarian dynamics, reproductive ecotoxicology, modeling the hormonal cycle --- Metabolic Databases and metabolic models *Computational Demography, Epidemiology, and Statistics/Biostatistics --- Classical demographic, epidemiologic, and biostatistical modeling --- Modeling of the role of culture, poverty, and other sociological issues as they impact healthcare --- Morphometrics *Computational Disease Modeling --- AIDS --- TB --- Influenza --- Statistical Population Genetics Of Disease Processes --- Other *Computational Biofluids --- Blood flow --- Sperm dynamics --- Modeling of arteriosclerosis and related processes *Computational Dentistry, Orthodontics, and Prosthetics *Computational Veterinary Medicine --- Computational issues in modeling non-human dynamics such as equine, feline, canine dynamics (physiological/biomechanical) *Computational Allied Health Sciences --- Physical Therapy --- Neuromusic Therapy --- Respiratory Therapy *Computational Radiology --- Dose modeling --- Treatment planning *Computational Surgery --- Simulation of surgical procedures in VR worlds --- Surgical simulation as a precursor to surgical intervention --- The Visible Human *Computational Cardiology *Computational Nursing *Computational Models In Chiropractice *Computational Neurobiology and Neurophysiology --- Brain modeling --- Single neuron models --- Neural nets and clinical applications --- Neurophysiological dynamics --- Neurotransmitter modeling --- Neurological disorder modeling (Alzheimer's Disease, for example) --- The Human Brain Project *Computational Models of Psychiatric and Psychological Processes *Computational Biomechanics --- Bone Modeling --- Joint Modeling *Computational Models of Non-traditional Medicine --- Acupuncture --- Other *Computational Issues In Medical Instrumentation Design and Simulation --- Scanner Design --- Optical Instrumentation *Ethical issues arising in the use of computational technology in medical diagnosis and simulation *The role of alternate reality methodologies and high performance environments in the medical and public health disciplines *Issues in the use of high performance computing environments in the teaching of health science curricula *The role of high performance environments for the handling of large medical datasets (high performance storage environments, high performance networking, high performance medical records manipulation and management, metadata structures and definitions) *Federal and private support for transdisciplinary research in computational medicine and public health 3.0 CONFERENCE COMMITTEE *CONFERENCE CHAIR: Matthew Witten, UT System Center For High Performance Computing, Austin, Texas m.witten@chpc.utexas.edu *CURRENT CONFERENCE DIRECTORATE: Regina Monaco, Mt. Sinai Medical Center Dan Davison, University of Houston Chris Johnson, University of Utah Lisa Fauci, Tulane University Daniel Zelterman, University of Minnesota Minneapolis James Hyman, Los Alamos National Laboratory Richard Hart, Tulane University Dennis Duke, SCRI-Florida State University Sharon Meintz, University of Nevada Los Vegas Dean Sittig, Vanderbilt University Dick Tsur, UT System CHPC Dan Deerfield, Pittsburgh Supercomputing Center Istvan Gyori, University of Veszprem (Hungary) Don Fussell, University of Texas at Austin Ken Goodman, University Of Miami School of Medicine Martin Hugh-Jones, Louisiana State University Stuart Zimmerman, MD Anderson Cancer Research Center John Wooley, DOE Sylvia Spengler, University of California Berkeley Robert Blystone, Trinity University Gregory Kramer, Santa Fe Institute Franco Celada, NYU Medical Center David Robinson, NIH, NHLBI Jane Preson, MCC Peter Petropoulos, Brooks Air Force Base Marcus Pandy, University of Texas at Austin George Bekey, University of Southern California Stephen Koslow, NIH, NIMH Fred Bookstein, University of Michigan Ann Arbor Dan Levine, University of Texas at Arlington Richard Gordon, University of Manitoba (Canada) Stan Zeitz, Drexel University Marcia McClure, University of Nevada Las Vegas Renato Sabbatini, UNICAMP/Brazil (Brazil) Hiroshi Tanaka, Tokyo Medical and Dental University (Japan) Shusaku Tsumoto, Tokyo Medical and Dental University (Japan) Additional conference directorate members are being added and will be updated on the anonymous ftp list as they agree. 4.0 CONTACTING THE CONFERENCE COMMITTEE: To contact the congress organizers for any reason use any of the following pathways: ELECTRONIC MAIL - compmed94@chpc.utexas.edu FAX (USA) - (512) 471-2445 PHONE (USA) - (512) 471-2472 GOPHER: log into the University of Texas System-CHPC select the Computational Medicine and Allied Health menu choice ANONYMOUS FTP: ftp.chpc.utexas.edu cd /pub/compmed94 POSTAL: Compmed 1994 University of Texas System CHPC Balcones Research Center 10100 Burnet Road, 1.154CMS Austin, Texas 78758-4497 5.0 SUBMISSION PROCEDURES: Authors must submit 5 copies of a single-page 50-100 word abstract clearly discussing the topic of their presentation. In addition, authors must clearly state their choice of poster, contributed paper, tutorial, exhibit, focused workshop or birds of a feather group along with a discussion of their presentation. Abstracts will be published as part of the preliminary conference material. To notify the congress organizing committee that you would like to participate and to be put on the congress mailing list, please fill out and return the form that follows this announcement. You may use any of the contact methods above. If you wish to organize a contributed paper session, tutorial session, focused workshop, or birds of a feather group, please contact the conference director at mwitten@chpc.utexas.edu . The abstract may be submitted electronically to compmed94@chpc.utexas.edu or by mail or fax. There is no official format. 6.0 CONFERENCE DEADLINES AND FEES: The following deadlines should be noted: 1 November 1993 - Notification of intent to organize a special session 15 December 1993 - Abstracts for talks/posters/ workshops/birds of a feather sessions/demonstrations 15 January 1994 - Notification of acceptance of abstract 15 February 1994 - Application for financial aid 1 April 1994 - Registration deadline (includes payment of all fees) Fees include lunches for three days, all conference registration materials, the reception, and the sit down banquet: $400.00 Corporate $250.00 Academic $150.00 Student Students are required to submit verification of student status. The verification of academic status form appears appended to the registration form in this announcement. Because financial aid may be available for minority students, faculty, and for individuals from declared minority institutions, you may indicate that you are requesting financial aid as a minority individual. Additionally, we anticipate some support for women to attend. Application for financial aid is also appended to the attached form. 7.0 CONFERENCE PRELIMINARY DETAILS AND ENVIRONMENT LOCATION: Hyatt Regency Hotel, Austin, Texas, USA DATES: 24-28 April 1994 The 1st World Congress On Computational Medicine, Public Health, and Biotechnology will be held at the Hyatt Regency Hotel, Austin, Texas located in downtown Austin on the shores of Town Lake, also known as the Colorado River. The Hyatt Regency has rooms available for the conference participants at a special rate of $79.00/night for single or double occupancy, with a hotel tax of 13%. The Hyatt accepts American Express, Diner's Club, Visa, MasterCard, Carte Blanche, and Discover credit cards. This room rate will be in effect until 9 April 1994 or until the block of rooms is full. We recommend that you make your reservations as soon as possible. You may make your reservations by calling (512) 477-1234 or by returning the enclosed reservation form. Be certain to mention that you are attending the First World Congress On Computational Medicine, Public Health, and Biotechnology if you make your reservations by telephone. The hotel is approximately, five miles (15 minutes from Robert Mueller Airport). The Hyatt offers courtesy limousine service to and from the airport between the hours of 6:00am and 11:00pm. You may call them from the airport when you arrive. If you choose to use a taxi, expect to pay approximately $8.00. Automobiles may be rented, at the airport, from most of the major car rental agencies. However, because of the downtown location of the Congress and access to taxis and to bus service, we do not recommend that you rent an auto unless you are planning to drive outside of the city. Should you not be able to find an available room at the Hyatt Regency, we have scheduled an "overflow" hotel, the Embassy Suites, which is located directly across the street from the Hyatt Regency. If, due to travel expense restrictions, you are unable to stay at either of these two hotels, please contact the conference board directly and we will be more than happy to find a hotel near the conference site that should accommodate your needs. Austin, the state capital, is renowned for its natural hill-country beauty and an active cultural scene. Several hiking and jogging trails are within walking distance of the hotel, as well as opportunities for a variety of aquatic sports. From the Hyatt, you can "Catch a Dillo" downtown, taking a ride on our delightful inner-city, rubber-wheeled trolley system. In Austin's historic downtown area, you can take a free guided tour through the State Capitol Building, constructed in 1888. Or, you can visit the Governor's Mansion, recognized as one of the finest examples of 19th Century Greek Revival architecture and housing every Texas governor since 1856. Downtown you will find the Old Bakery and Emporium, built by Swedish immigrant Charles Lundberg in 1876 and the Sixth Street/Old Pecan Street Historical District - a seven-block renovation of Victorian and native stone buildings, now a National Registered Historic District containing more than 60 restaurants, clubs, and shops to enjoy. The Laguna Gloria Art Museum, the Archer M. Huntington Art Gallery, the LBJ Library and Museum, the Neill-Cochran Museum House, and the Texas Memorial Museum are among Austin's finest museums. The Umlauf Sculpture Garden, has become a major artistic attraction. Charles Umlauf's sculptured works are placed in a variety of elegant settings under a canopy of trees. The Zilker Gardens contains many botanical highlights such as the Rose Garden, Oriental Garden, Garden of the Blind, Water Garden and more. Unique to Austin is a large population of Mexican free-tailed bats which resides beneath the Congress Avenue Bridge. During the month of April, the Highland Lakes Bluebonnet Trail celebrates spring's wildflowers (a major attraction) as this self-guided tour winds through the surrounding region of Austin and nearby towns (you will need to rent a car for this one). Austin offers a number of indoor shopping malls in every part of the city; The Arboretum, Barton Creek Square, Dobie Mall, and Highland Mall, to name a few. Capital Metro, Austin's mass transit system, offers low cost transportation throughout Austin. Specialty shops, offering a wide variety of handmade crafts and merchandise crafted by native Texans, are scattered throughout the city and surrounding areas. Dining out in Austin, you will have choices of American, Chinese, Authentic Mexican, Tex-Mex, Italian, Japanese, or nearly any other type of cuisine you might wish to experience, with price ranges that will suit anyone's budget. Live bands perform in various nightclubs around the city and at night spots along Sixth Street, offering a range of jazz, blues, country/Western, reggae, swing, and rock music. Day temperatures will be in the 80-90(degrees F) range and fairly humid. Evening temperatures have been known to drop down into the 50's (degrees F). Cold weather is not expected so be sure to bring lightweight clothing with you. Congress exhibitor and vendor presentations are also being planned. 8.0 CONFERENCE ENDORSEMENTS AND SPONSORSHIPS: Numerous potential academic sponsors have been contacted. Currently negotiations are underway for sponsorship with SIAM, AMS, MAA, IEEE, FASEB, and IMACS. Additionally AMA and ANA continuing medical education support is being sought. Information will be updated regularly on the anonymous ftp site for the conference (see above). Currently, funding has been generously supplied by the following agencies: University of Texas System - CHPC U.S. Department of Energy ================== REGISTRATION FORM =============== (Please list your name below as it will appear on badge.) First Name : Middle Initial (if available): Family Name: Your Professional Title: [ ]Dr. [ ]Professor [ ]Mr. [ ]Mrs. [ ]Ms. [ ]Other:__________________ Office Phone (desk): Home/Evening Phone (for emergency contact): Fax: Electronic Mail (Bitnet): Electronic Mail (Internet): Postal Address: Institution or Center: Building Code: Mail Stop: Street Address1: Street Address2: City: State: Zip or Country Code: Country: Please list your three major interest areas: Interest1: Interest2: Interest3: Registration fee: $____________ Late fee $50 (if after April 1, 1994) $____________ **IF UT AUSTIN, PLEASE PROVIDE YOUR: UNIVERSITY ACCT. #: ______________________ UNIVERSITY ACCT. TITLE: ______________________ NAME OF ACCT. SIGNER: ______________________ ===================================================== VERIFICATION OF STUDENT STATUS Name: Mailing Address: University at which you are a student: What level student(year): Your student id number: Name of your graduate or postdoctoral advisor: Telephone number for your advisor: By filling in this section, I agree that I am electronically signing my signature to the statement that I am currently a student at the above university. ======================================================= REQUEST FOR FINANCIAL AID Name: Mailing Address: I request financial assistance under one or more of the following categories: [ ] Student (You must fill out the Verification of Student Status Section in order to be considered for financial aid under this category) [ ] Academic [ ] Minority [ ] Female [ ] Black [ ] Hispanic [ ] Native American Indian [ ] Other This form is not meant to invade your personal privacy in any fashion. However, some of the grant funds are targeted at specific ethnic/minority groups and need to be expended appropriately. None of these forms will be in any way released to the public. And, after the congress, all of the financial aid forms will be destroyed. No records will be kept of ethnic or racial backgrounds. If you have any questions concerning financial aid support, please contact Matthew Witten at the above addresses. ============================================================== From owner-ageing@net.bio.net Tue Sep 14 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!darwin.sura.net!RBSE.Mountain.Net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: KUCHTA@TCUCVMS.BITNET (Tim Kuchta) Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: Upcoming Gerontological Symposium Message-ID: <01H2XYAF9GTE0002ZM@GAMMA.IS.TCU.EDU> Date: 14 Sep 93 20:06:23 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Lines: 238 Xref: biosci bionet.molbio.ageing:481 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: KUCHTA <@UBVM.CC.BUFFALO.EDU:KUCHTA@TCUCVMS.BITNET> To: Marshall University X-VMS-To: IN%"gerinet@ubvm.bitnet" MIME-version: 1.0 Content-type: TEXT/PLAIN; CHARSET=US-ASCII Content-transfer-encoding: 7BIT X-To: gerinet@ubvm.bitnet TEXAS CHRISTIAN UNIVERSITY HARRIS COLLEGE OF NURSING Presents THE THIRD HOGSTEL GERONTOLOGICAL NURSING RESEARCH SYMPOSIUM Featuring Irene Burnside, Ph.D., RN, FAAN Visiting Professor Greensboro, North Carolina October 15, 1993 Annie Richardson Bass Building - TCU SPONSORS Sigma Theta Tau International Honor Society of Nursing Beta Alpha Chapter, Texas Christian University Mildred Hogstel, Ph.D., RN, C. Texas Christian University - Harris College of Nursing "This offering, CNE #0-A0-4677-8-93 has been approved for 5.4 contact hours by the Texas Nurses Association. TNA is accredited as an approver of continuing education by the American Nurses Credentialing Center Commission on Accreditation. This approval meets Type 1 criteria for mandatory continuing education requirements toward relicensure as established by the Board of Nurse Examiners for the State of Texas." ******************** Dr. Irene Burnside is a Visiting Professor at the University of North Carolina School of Nursing. She holds a master's degree in adult psychiatric nursing from the University of California in San Francisco and also a post master's certificate. At the age of 66, she received her doctoral degree in Gerontological Nursing from the University of Texas at Austin. She is well known internationally as a lecturer, consultant, and author in the field of gerontological nursing. Her books "Psychosocial Nursing Care of the Aged", "Working with the Elderly: Group Process and Techniques" and "Psychosocial Caring Throughout the Life Span", have all received Book of the Year awards from the American Journal of Nursing. In addition to her books, Dr. Burnside is the author of 16 chapters in books and more than 40 articles in professional journals. She is also a published poet. Honored by her colleagues, Dr. Burnside has received the first Long Term Care award given by the National League for Nursing, the Geronting award given by the Andrus Gerontology Center at the University of Southern California, and the Meritorious Service Award from the American Association of Homes of the Aging. She has also received the Lulu Hassenplug award from the California Nurses Association and the Gerontological Nurse of the Year by the American Nurses Association. In 1991, Sigma Theta Tau awarded Dr. Burnside the Excellence in Creativity Award for her commitment to gerontological nursing practice. Dr. Burnside is a Fellow of the American Academy of Nursing and the Gerontological Society of America. POSTER PRESENTATIONS (1) A Continuing Education Model for Improving the Knowledge of Aging Among Practicing Registered Nurses Roberta Burris, PhD, RN Assistant Professor University of Texas at Tyler Tyler, Texas (2) Skin Care Practices for the Elderly in Nursing Homes in the United States Rose Nieswiadomy, PhD, RN Professor Texas Woman's University Dallas, Texas (3) Toward A Theory of Physiologic Regeneration: Application to Gerontological Nursing Research Jane Schade Henderson, MN, RN Denton, Texas (4) The Contextual Environment of Nursing Homes Christina M. Sheehy, DPA, RN Assistant Professor and Project Director University of Arizona College of Nursing Tucson, Arizona (5) Nurse Aide Turnover in Texas Long-Term Care Facilities Ferne N. Kyba, PhD, RN Assistant Professor Carol A. Rice, PhD, RN Specialist University of Texas at Arlington Arlington, Texas (6) Improving Functional Mobility Through Exercise Lilly J. Noble, MSN, RN, CPT AN Oncology Nurse Specialist - U.S. Army Nurse Corps Brook Army Medical Center Fort Sam Houston, Texas ************************* HOGSTEL GERONTOLOGICAL NURSING RESEARCH SYMPOSIUM PROGRAM TIME PRESENTATION -------------------------------------------------------------------------- 8:00 - 9:00 Registration, Refreshments and Poster Presentations 9:00 - 9:15 Welcome: Patricia D. Scearse, DNSc, RN, Dean and Professor of Nursing Harris College of Nursing Introductions 9:15 - 10:30 Keynote address: Future Research: Reminiscence and Life Review Irene Burnside, PhD, RN, FAAN 10:30 - 11:15 Break Poster Presentations and Exhibits 11:15 - 12:00 Concurrent Sessions 12:00 - 1:15 Lunch (On your own or box lunch available for additional fee) 1:15 - 2:45 Concurrent Sessions 2:45 - 3:00 Break 3:00 - 4:00 Comments with Dr. Burnside 4:00 - 4:30 Evaluation ************************* CONCURRENT SESSIONS Each participant will select one presentation per session for a total of three presentations attended. 11:15 A.M. - 12:00 P.M. (A) The Lived Experience of Dying at Home: A Phenomenological Study Guided by Parse's Emergent Methodology Mary Lynd, MSN, RNC Director of RN-BSN and MSN Nursing Outreach Program Bellarmine College Minford, Ohio (B) The Relationships Among Humor, Divergent Thinking, and Coping With Retirement in Older Adults Melinda Williams, PhD, RN Visiting Assistant Professor University of Texas at Tyler Tyler, Texas 1:15 P.M. - 2:00 P.M. (A) Factors Which Influence the Self-Medication Practices of Low-Income Elderly Women K. Lynn Wieck, PhD, RN Assistant Professor of Nursing Texas Woman's University Houston, Texas (B) Hope: Older Adult Perspective Kaye Ann Herth, PhD, RN Professor and Chair Department of Nursing Georgia Southern University Statesboro, Georgia 2:00 P.M. - 2:45 P.M. (A) Nurses' Views About Physical Restraint Use with Hospitalized Older Persons Karen V. Lamb, ND, RN Assistant Professor Rush University College of Nursing Chicago, Illinois (B) Satisfaction with Residency, Sense of Well-Being, Perception of Social Support and Selected Demographics as Determinants of Loneliness in Elderly Nursing Home Residents Rita Kay Spinn, PhD, RN Professor of Nursing McLennan Community College Waco, Texas ************************* A block of rooms has been reserved at the Marriott Residence Inn, 1701 South University, Fort Worth, TX 76109; (817) 870-1011. This hotel is just minutes away from the TCU campus and approximately 45 minutes from D/FW International Airport. Room availability for this conference is effective October 14-16th and includes a studio room rate of $75 per night with continental breakfast. The deadline date for hotel reservations is September 30th. Please call the hotel directly to make reservations and use the name of this conference when making reservations. ************************* Be advised that there is a fee for this symposium, so for additional information and questions call: Freda Murray at (817) 921-7497 or write to her at: Freda Murray TCU-Harris College of Nursing P.O. Box 32899 Fort Worth, Texas 76129 The form below can also be used as a registration form -------------------------------------------------------------------------- The Third Hogstel Gerontological Nursing Research Symposium October 15, 1993 - Annie Richardson Bass Building - TCU __________________________________________________________________________ First Name MI Last Name Social Security Number __________________________________________________________________________ Home Address City State Zip Code __________________________________________________________________________ Employment Place and Position __________________________________________________________________________ Address of Employer City State Zip Code __________________________________________________________________________ (AC) Business Telephone (AC) Home Telephone Circle the letter of each concurrent session you plan to attend: 11:15-12:00 A or B 1:15-2:00 A or B 2:00-2:45 A or B From owner-ageing@net.bio.net Tue Sep 14 23:00:00 1993 Path: biosci!lhc!darwin.sura.net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: GDEKKER@MED.RUU.NL (Gerard Dekker) Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: oproep kontakt en informatie Message-ID: <01H2Z58G5SDE9BYLO9@med.ruu.nl> Date: 15 Sep 93 09:37:49 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Organization: Medical Faculty, Utrecht University, The Netherlands Lines: 31 Xref: biosci bionet.molbio.ageing:482 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: GDEKKER<@UBVM.CC.BUFFALO.EDU,@VM42.CSO.UIUC.EDU:GDEKKER@MED.RUU.NL> To: Marshall University X-VMS-To: IN%"gerinet%ubvm.bitnet@vm42.cso.uiuc.edu" X-VMS-Cc: GDEKKER MIME-version: 1.0 Content-type: TEXT/PLAIN; CHARSET=US-ASCII Content-transfer-encoding: 7BIT X-To: gerinet@ubvm.bitnet Dear reader, Since april, 93 I'm doing research on dialysis-patients. The subject of my research has to do with the compliance of pa- tients with a restricted fluid-intake. Within the department where I'm working we are starting 'in- formation analysis' as a first step in automation of the care process. Of course I'm interested in programs and experiences in this area. I should like to develop contacts with nurses who work with dialysis patients and who are interested in the same areas. Please contact me, Gerard Dekker ********************************************************* Gerard W. Dekker, RN Headnurse Dialysis Department University Hospital Utrecht Heidelberglaan 100 3584 CX UTRECHT THE NETHERLANDS Phone +31 (30) 507326 Fax +31 (30) 543492 Internet: gdekker@med.ruu.nl ********************************************************* From owner-ageing@net.bio.net Wed Sep 15 23:00:00 1993 Path: biosci!URIACC.URI.EDU!GGMURRAY From: GGMURRAY@URIACC.URI.EDU (Gail Murray) Newsgroups: bionet.molbio.ageing Subject: (none) Message-ID: <9309161701.AA09115@net.bio.net> Date: 16 Sep 93 16:59:49 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 13 Question: It is said that the cells of our bodies are completely replaced every 7 years or so. If this is so, and all cells are replenished, what is it that ages? ------------------------------------------------------------------------- * GAIL MURRAY, SENIOR PROGRAMMER ANALYST ADMINISTRATIVE COMPUTER CENTER PHONE: (401) 792-2611 LIPPITT HALL FAX: (401) 792-5479 University of Rhode Island Kingston, RI 02881-0814 ...standard disclaimer, with hearts * ------------------------------------------------------------------------- From owner-ageing@net.bio.net Thu Sep 16 23:00:00 1993 Path: biosci!POSSUM.MURDOCH.EDU.AU!cummins From: cummins@POSSUM.MURDOCH.EDU.AU (Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Re: your mail Message-ID: Date: 17 Sep 93 01:03:06 GMT References: <9309161701.AA09115@net.bio.net> Sender: daemon@net.bio.net Distribution: bionet Lines: 31 Ageing is thought to occur mainly in postmitotic tissues such as brain and muscle. Check Miquel, J. An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells. Arch Gerontol Geriatrics 1991: 12: 88-117 Dr Jim Cummins +61-9-360 2668 School of Veterinary Studies FAX =61-9-310 4144 Murdoch University cummins@possum.murdoch.edu.au Murdoch, Western Australia 6150 "For every complex problem there's a simple solution. And it's wrong!" On Thu, 16 Sep 1993, Gail Murray wrote: > Question: It is said that the cells of our bodies are completely > replaced every 7 years or so. If this is so, and all > cells are replenished, what is it that ages? > > ------------------------------------------------------------------------- > * > GAIL MURRAY, SENIOR PROGRAMMER ANALYST > ADMINISTRATIVE COMPUTER CENTER PHONE: (401) 792-2611 > LIPPITT HALL FAX: (401) 792-5479 > University of Rhode Island > Kingston, RI 02881-0814 ...standard disclaimer, with hearts > * > ------------------------------------------------------------------------- From owner-ageing@net.bio.net Thu Sep 16 23:00:00 1993 Path: biosci!daresbury!daresbury!news From: bafa1@uk.ac.sussex.central (Sydney Shall) Newsgroups: bionet.molbio.ageing Subject: How do we age? Message-ID: <1993Sep17.111919.5186@gserv1.dl.ac.uk> Date: 17 Sep 93 11:18:33 GMT Sender: list-admin@daresbury.ac.uk Distribution: bionet Lines: 60 Precedence: first-class Original-To: Ageing@uk.ac.daresbury X-Mailer: ELM [version 2.3 PL11] Gail Murray asked today how is it that we age, if our cells are replaced very frequently. In fact, our cells are sometimes replaced much more frequently than every several years; skin cells are replaced in days and weeks, and cells in the gut are replaced every few days. Jim Cummins responded to the query from Gail Murray by saying that ageing ONLY (my emphasis) occurs in post-mitotic tissues, that is tissues in which the cells have stopped dividing. This is only partially true. The ageing of post-mitotic tissues such as neuronal (brain) cells and muscle cells is very important, but there is also ageing in other tissues in which there is cell division; so how do we explain this type of ageing. I propose (following the original idea from George Martin of Seattle) that it is the using up of the proliferative potential which we have in most of our bodies that prevents adequate regeneration of damaged cells in any given tissue. Thus in older people, I suppose that their tissues cannot maintain themselves adequately, because the cells cannot raplace damaged cells efficiently. This idea is very well supported by the human genetic disease called Werner's Syndrome, in which people age prematurely in a very dramatic fashion. In this disease there is no fast ageing in the non-dividing tissue, only in some of the dividing tissue. This disease therefore demonstrates that there is a form of premature ageing, and therefore presumably, a form also of normal ageing that only affects certain dividing tissues. The details of the loss of ability to divide in this condition have recently been worked out. The disease is also interesting because we know that it is caused by ONE single mendelian locus on one of the non-sex chromosomes. Attempts are being made to identify the relevant gene and to isolate it to see how it works. ************************************************************************** ************************************************************************** Sydney SHALL, Laboratory of Cell and Molecular Biology, Biology Building, University of Sussex, Brighton, East Sussex BN1 9QG, ENGLAND. Telephone: +44.273.67.83.03 FAX: +44.273.67.83.33 E-Mail: Janet: BAFA1@uk.ac.sussex.central Elsewhere: BAFA1@central.sussex.ac.uk EARN/BITNET: BAFA1%sussex.central@ukacrl ******************************************************************************* ******************************************************************************* From owner-ageing@net.bio.net Thu Sep 16 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!darwin.sura.net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: BROW7242@SNYPLAVA.BITNET (NAME "Mariruth Brown") Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: Message-ID: <01H30T17AKQQ9JF5X1@splava.cc.plattsburgh.edu> Date: 16 Sep 93 21:08:54 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Organization: SUNY at Plattsburgh, New York, USA Lines: 2 Xref: biosci bionet.molbio.ageing:486 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Subj: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: BROW7242 <@UBVM.CC.BUFFALO.EDU:BROW7242@SNYPLAVA.BITNET> To: Marshall University X-VMS-To: IN%"GERINET@UBVM" X-VMS-Cc: BROW7242 MIME-version: 1.0 Content-transfer-encoding: 7BIT Date sent: 16-SEP-1993 16:08:35 subscribe GERINET Mariruth Brown From owner-ageing@net.bio.net Thu Sep 16 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!warwick!not-for-mail From: cuhes@csv.warwick.ac.uk (Malcolm McMahon) Newsgroups: bionet.molbio.ageing Subject: Re: How do we age? Message-ID: <27cbof$619@violet.csv.warwick.ac.uk> Date: 17 Sep 93 12:49:19 GMT References: <1993Sep17.111919.5186@gserv1.dl.ac.uk> Distribution: bionet Organization: Computing Services, University of Warwick, UK Lines: 20 NNTP-Posting-Host: violet.csv.warwick.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=US-ASCII Content-Transfer-Encoding: 7bit In article <1993Sep17.111919.5186@gserv1.dl.ac.uk>, >I propose (following the original idea from George Martin of Seattle) that it >is the using up of the proliferative potential which we have in most of our >bodies that prevents adequate regeneration of damaged cells in any given tissue. >Thus in older people, I suppose that their tissues cannot maintain themselves >adequately, because the cells cannot raplace damaged cells efficiently. > There is also the very intersting idea that this "finite proliferative potential" is there for a very good reason. By limiting the number of cell generations in tissue other than, for example, the gut lining you provide a very efficient defense against cancer. To be a "successful" cancer a cell has to knock out this mechanism as well as the normal controlls on division. If you assume that the two mechanisms are independant and equally likely to be knocked out by mutation the chances of you getting cancer in a given period could be reduced to the square root of the current value if the Hayflick limit were repealed. Malcolm McMahon From owner-ageing@net.bio.net Fri Sep 17 23:00:00 1993 Path: biosci!daresbury!daresbury!news From: bafa1@uk.ac.sussex.central (Sydney Shall) Newsgroups: bionet.molbio.ageing Subject: How do we age? Message-ID: <1993Sep18.121310.24154@gserv1.dl.ac.uk> Date: 18 Sep 93 12:12:33 GMT Sender: list-admin@daresbury.ac.uk Distribution: bionet Lines: 12 Precedence: first-class Original-To: AGEING@uk.ac.daresbury X-Mailer: ELM [version 2.3 PL11] I believe that Malcolm McMahon has clearly expressed the essential evolutionary rationale for the "Hayflick" limit, that is the finite proliferative capacity of most somatic cell types. Primarily, it is a protection against cancer, because a cell which has been transformed to morphological or metastatic malignancy, but still has a finite lifespan will in many circumstances not kill the host. Sydney SHALL S.Shall@sussex.central.ac.uk From owner-ageing@net.bio.net Fri Sep 17 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!spool.mu.edu!darwin.sura.net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: ABARE@SMCVAX.BITNET Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: Message-ID: <01H326TDGKQQ8Y5YK6@SMCVAX.SMCVT.EDU> Date: 17 Sep 93 20:54:28 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Lines: 1 Xref: biosci bionet.molbio.ageing:489 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Subj: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: ABARE <@UBVM.CC.BUFFALO.EDU:ABARE@SMCVAX.BITNET> To: Marshall University X-VMS-To: IN%"Gerinet@UBVM" MIME-version: 1.0 Content-type: TEXT/PLAIN; CHARSET=US-ASCII Content-transfer-encoding: 7BIT Please subscribe me to your list Amy Abare @smcvax.smcvt.edu From owner-ageing@net.bio.net Fri Sep 17 23:00:00 1993 Path: biosci!agate!headwall.Stanford.EDU!bcm!th035681 From: th035681@mbcr.bcm.tmc.edu (Timothy R. Hughes) Newsgroups: bionet.molbio.ageing Subject: Cellular Senescence = Tumor Control ? Message-ID: <27g0rl$oeg@gazette.bcm.tmc.edu> Date: 18 Sep 93 22:07:49 GMT Organization: Baylor College of Medicine, Houston, Tx Lines: 54 NNTP-Posting-Host: mbcr.bcm.tmc.edu Originator: th035681@mbcr.bcm.tmc.edu While the idea that cellular senescence has evolved as a means of containing morphological or metastatic malignancies is attractive and obviously cannot be disproven, I am not convinced that it is accurate. The immune response is supposed to eliminate errant cells, and in the event that malignant cells have escaped the immune reponse and are proliferating when they shouldn't, they have definitely abandoned their normal growth controls, and the senescent property is certainly no guarantee. This is in fact how transformed cells are identified in cell culture - they don't senesce. I have personally never heard of a tumor ceasing growth and upon inspection it was found that all of its cells had senesced, and I would sure be interested if anyone had. If humans _were_ to depend on senescence to control tumorous growth of cells escaping both the immune system and their normal growth restrictions, we would wind up with pretty big tumors anyway, judging from the division potential of fibroblasts in vitro (a model which is another issue entirely). Roughly estimating that fetal fibroblasts have a division potential of 100 and lose one division per year, at the age of forty a malignant growth could still reach 2^60 cells, which is a pretty big tumor. (As age reaches 100, of course, the possible tumor size decreases exponentially. I chose 40 as the age at which selective pressure was probably largely removed during most of human evolution.) Tim Hughes (I am a first-year graduate student at the Baylor College of Medicine. I am hoping to do my thesis work in Jim & Olivia Smith's lab, where I worked over the summer. I am fascinated by the aging process and would be interested in corresponding with anyone in a similar position.) From owner-ageing@net.bio.net Sat Sep 18 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!europa.eng.gtefsd.com!uunet!mcsun!sunic!corax.udac.uu.se!zeta.bmc.uu.se!daresbury!daresbury!news From: bafa1@uk.ac.sussex.central (Sydney Shall) Newsgroups: bionet.molbio.ageing Subject: Cellular senescence Message-ID: <1993Sep19.103502.13618@gserv1.dl.ac.uk> Date: 19 Sep 93 10:34:24 GMT Sender: list-admin@daresbury.ac.uk Distribution: bionet Lines: 52 Precedence: first-class Original-To: AGEING@uk.ac.daresbury X-Mailer: ELM [version 2.3 PL11] Timothy Hughes responds to my view that cellular senescence is a protection against tumours with two common counter-arguments. He suggests that there is immune surveillance of tumours; this idea has been considered and investigated for many decades. At the moment the conclusion is very unclear. While it seems that some tumours may be immunogenic, it appears that most tumours are bvery poorly immunogenic. In addition, as I read the literature there is very little hard evidence for immune surveillance of tumours as a major protective function. The second point is the large proliferative capacity of fibroblasts in vitro. While this appears to be a serious obstacle to the idea, Timothy himself points out that in general tumours never (?) senesce. The fact is that an extended life-span or immortalization is the most universal common phenotype in tumours; there is an almost perfect correllation between "natural" tumours and immortalization. Of course, it has been frequently pointed out that immortalization of a cell clone may be a necessary requirement for a tumour, but it is clearly not a sufficient condition. Additional morphological and "malignant" alterations are also required. ************************************************************************** ************************************************************************** Sydney SHALL, Laboratory of Cell and Molecular Biology, Biology Building, University of Sussex, Brighton, East Sussex BN1 9QG, ENGLAND. Telephone: +44.273.67.83.03 FAX: +44.273.67.83.33 E-Mail: Janet: BAFA1@uk.ac.sussex.central Elsewhere: BAFA1@central.sussex.ac.uk EARN/BITNET: BAFA1%sussex.central@ukacrl ******************************************************************************* ******************************************************************************* From owner-ageing@net.bio.net Sun Sep 19 23:00:00 1993 Path: biosci!rutgers!cs.utexas.edu!uunet!pipex!uknet!warwick!not-for-mail From: cuhes@csv.warwick.ac.uk (Malcolm McMahon) Newsgroups: bionet.molbio.ageing Subject: Re: Cellular Senescence = Tumor Control ? Message-ID: <27k33a$5o2@violet.csv.warwick.ac.uk> Date: 20 Sep 93 11:10:34 GMT References: <27g0rl$oeg@gazette.bcm.tmc.edu> Organization: Computing Services, University of Warwick, UK Lines: 65 NNTP-Posting-Host: violet.csv.warwick.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=US-ASCII Content-Transfer-Encoding: 7bit In article <27g0rl$oeg@gazette.bcm.tmc.edu>, th035681@mbcr.bcm.tmc.edu (Timothy R. Hughes) writes: > >While the idea that cellular senescence has >evolved as a means of containing morphological >or metastatic malignancies is attractive and >obviously cannot be disproven, I am not convinced >that it is accurate. The immune response >is supposed to eliminate errant cells, and >in the event that malignant cells have escaped >the immune reponse and are proliferating when they >shouldn't, they have definitely abandoned their normal >growth controls, and the senescent property is >certainly no guarantee. This is in fact how >transformed cells are identified in cell culture - >they don't senesce. I have personally never heard >of a tumor ceasing growth and upon inspection it >was found that all of its cells had senesced, and >I would sure be interested if anyone had. > Yes, but if the mechanism was sufficienly effective then you would only see a malignant tumour at all where it had failed. How about warts, for example? > Roughly estimating that fetal fibroblasts >have a division potential of 100 and lose >one division per year, at the age of forty >a malignant growth could still >reach 2^60 cells, which is a pretty >big tumor. (As age reaches 100, of course, the possible tumor >size decreases exponentially. I chose 40 as the age >at which selective pressure was probably largely removed >during most of human evolution.) > OK that is strong aurgument but there are two posible ways arround it. Firstly in vitrio cell culture may be rather unlike in vivo grcwth. More importantly your simple calculation of tumour size assumes that the tumour is growing in a friendly environment. But it isn't. Its almost certainly going to be under immune attack. It's going to have respiration problems. I don't have much to back this up but I would assume, in the absence of evidence to the contrary, that tumour cells are going to have a pretty high mortality rate thus they are going to eat into the Hayflick limit faster than you are allowing for. I do though feel that whatever the ageing mechanism actually is that it must be something actively usefull. "Wearing out" type theories don't seem consistent with what we observe in evolution. Consider the anomolously high human longevity, for example. If, as it seems, evolution has been able to treble our lifespan in the short time since we developed a social structure with a use for grandparents it seems that given even a marginal incentive longevity evolves rather easilly. The experiments with drosophilia, breading for longer/shorter longevity suggest the same thing. It seems to me that the wear and tear theories suggest a running battle between competing processes and I don't think that would give you the right statistics. Where are the immortal mutants where the repair mechanisms are stronger than the demage mechanisms? Nor does the DNA degradation seem to make much sense. Why does DNA damage accumulate between generations of cells but not generation of animals? Malcolm McMahon From owner-ageing@net.bio.net Sun Sep 19 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!xlink.net!scsing.switch.ch!aristo.tau.ac.il!pc386 From: pc386@ccsg.tau.ac.il (BENNY SHOMER 9238) Newsgroups: bionet.molbio.ageing Subject: Primers database through gopher. Message-ID: <1993Sep20.174158.24632@aristo.tau.ac.il> Date: 20 Sep 93 17:41:58 GMT Sender: usenet@aristo.tau.ac.il (USENET) Organization: Tel-Aviv University Computation Center Lines: 163 X-Newsreader: TIN [version 1.2 PL1] Hello Bionetters. It has been recently suggested that a searchable database of primers for PCR will be set. The basic idea behind this database is that only ___TESTED_&_WORKING___ (!!!) primers should be contained. This may save many valuable planning and working hours, as well as money. We all know that even carefully planned primers fail to operate when it comes down to the tubes... Dan Jacobson from the Johns Hopkins Univ. GDB, and your humble servant, are now working on the establishment of this database as a gopher server. Cited below is the suggested basic form for this database. We now open a discussion regarding the suggested data fields. We are interested in hearing your opinions regarding this form. Please pay attention to the following: 1. This message has been cross posted to several bionet.xxxx groups. It is suggested however, that the thread will be maintained in bionet.molbio. methds-reagnts . This will make it easier to read and respond to everyone's followups. 2. A followup to the newsgroup is prefferred over direct responses in the Email, so as to keep the thread open. If, for any reason you want to contact us directly, Dan's address is: danj@gdb.org, my @ is: pc386@ccsg.tau.ac.il We hope that this thread will be constructive, and that the database will be 'on the air' as soon as possible. Greetings, Dan Jacobson, Benny Shomer. This is the suggested form: ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Primer Name: ______________________________ Target Gene: ______________________________________________________________ Species: ___________________________ Direction: { FOR / REV } Matching Primer(s) in this database: _________________________________ Sequence (5' --> 3'): ___________________________ Length: __ Flanking bases ______ to _____ on the target sequence. Product Length (cDNA):_______ Product Length (genomic):_______ {Lengths are in bp, or 0 for inverse PCR, where length is unknown} Restriction Site Added: _____________ Mutation presented at base: __ Special Applications: { Inverse/ RT-PCR/ Sequencing/ Cloning/ Mutation/ / Ligation Mediated} __________________________________________________________________________ __________________________________________________________________________ ******************** Cycle Conditions ********************************* Hot Start: {Yes/No} Initial Denaturation- Temp: __ Time: ____ Denaturation - Temp: __ Time: ____ Annealing - Temp: __ Time: ____ Extension - Temp: __ Time: ____ Number Of Cycles: __ Final Extension - Temp: __ Time: ____ ********************** Buffer Constituents **************************** (This section basically regards non-standard buffer constituents) Reaction Volume (ul): __ Used Standard Buffer Supplied By: _______________ MgCl2 Concentration (mM): __ DMSO Concentration (%): __ Formamide Concentration (%): __ Gelatin Concentration (%): __ dNTP's Concentration (uM): __ Primers Concentration (uM): __ Polymerase Type: ___________ Polymerase Concentration (U/Rxn.): ___ Make: _____________ ************************************************************************** Submitting Author. Name: __________________________________ Institution: ______________________________________________________________ __________________________________________________________________________ Address: _________________________________________________________________ __________________________________________________________________________ E-mail : ________________________________ Fax# : ______________________ References: __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ Remarks: __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ************************************************************** * Benny Shomer * * Tel-Aviv University * * Sackler School of Medicine, Dept.of Embryology and Teratology* *--------------------------------------------------------------* * Snail: Ramat-Aviv , Tel-Aviv 69978 , Israel. * * E-mail : pc386@ccsg.tau.ac.il * * Tel : 972-3-640-9238 FAX : 972-3-642-2046 * * * %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % So Many Computers , So Little Time ... % % % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% From owner-ageing@net.bio.net Mon Sep 20 23:00:00 1993 Path: biosci!NETCOM.COM!wick From: wick@NETCOM.COM (Potter Wickware) Newsgroups: bionet.molbio.ageing Subject: membrane viscosity and aging Message-ID: Date: 21 Sep 93 17:51:17 GMT Sender: daemon@net.bio.net Reply-To: Potter Wickware Distribution: bionet Lines: 73 Membrane viscosity and aging A few years ago I wrote a paper about membrane viscosity for a cell biology class. Certain of the papers I read asserted that cells get stiffer with age, and that this shift, (and hence aging itself), is reversible. The purpose of this post is to ask the group about attitudes today about aging vis-a-vis membrane viscosity. I haven't kept up with the literature, and don't know if this is still a direction viewed as fruitful or relevant. The essence of the idea was that aging at the cellular level is caused by a shift in the ratio of phosphatidyl choline (PC) (lecithin) to sphyngomyelin (SM), the major lipid components of plasma membranes. PC has a fluid character because it is liquid in the physiological temperature range. It is a membrane liquefier; cholesterol does not associate with it, and it tends to wash cholesterol out of membranes. SM, by contrast, is gelid and associates with cholesterol at physiological temperature, and is thus a membrane stiffener. Because of an unknown mechanism, the PC/SM ratio shifts toward SM in older cells. Therefore, older cells are stiffer and slower to respond to stimuli than younger cells. The stiffness or deformability of cells affects their interaction with other cells, and their ability to undergo exocytosis, phagocytosis and division. Also, the functional efficiency of membrane-bound proteins may be determined by how high or low they float in the membranes: antigens or active sites may be overexposed or suppressed, multimeric subunits may aggregate too slowly, loosely bound proteins may be shed into the medium, etc. M Shinitsky and Y Barenholz, Israeli biochemists, took the view that the flexibility of membranes could be restored by loading them with PC. They supposed that this could be accomplished simply through a lecithin-rich diet. Of course, if the membranes have been in a rigid condition long enough for membrane proteins to become abnormally cross-linked, or for covalent bonding to occur in the membrane-protein complex, adjusting the lipid balance would not do any good. But if the membrane proteins were still functionally intact, said the Israelis, their function could be restored or enhanced by fluidizing the membrane. They demonstrated their idea by feeding a lecithin-rich diet to rodents. They said the results, as measured by longevity and fertility of the animals, were dramatically better from those of the control group. They devised another controlled lipid exchange method by means of liposomes and demonstrated it in myocytes. Twitch frequency and other indicators of proficiency of these cells were also said to improve dramatically. A US patent covering "lipid replacement therapy" was granted to Barenholz and Shinitzky in '89; the licensee is Liposome Technology of Menlo Park, CA. I talked to this company some time ago; they were having financial difficulties then and were not doing anything with the patent. I have no recent news on the status of the patent. I'm interested to know if lipid replacement therapy is a reputable idea. I think the argument summarized here, and the potential value of lipid replacement treatments, depends on the assertion that the ratio of SM to PC increases with age. Is this true? What research is being done today? Who's doing it? Comments? Potter Wickware Oakland, CA wick@netcom.com From owner-ageing@net.bio.net Tue Sep 21 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!math.ohio-state.edu!magnus.acs.ohio-state.edu!csn!shaman.nexagen.com!shaman.nexagen.com!not-for-mail From: cordell@shaman.nexagen.com (Bruce Cordell) Newsgroups: bionet.molbio.ageing Subject: Re: membrane viscosity and aging Message-ID: <27nv4sINNi68@shaman.nexagen.com> Date: 21 Sep 93 22:27:40 GMT References: Distribution: bionet Organization: NeXagen.com Lines: 10 NNTP-Posting-Host: shaman.nexagen.com What foods naturally contain high concentrations of lecithin? Thanks! ___________________________________________________________________________ GOD IS NO WHERE Bruce Robert Cordell GOD IS NOW HERE cordell@shaman.nexagen.com ___________________________________________________________________________ From owner-ageing@net.bio.net Thu Sep 23 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!darwin.sura.net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: FWR10@PHOENIX.CAMBRIDGE.AC.UK (Wendy Roberts) Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: Info resources Message-ID: Date: 23 Sep 93 12:35:47 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Lines: 17 Xref: biosci bionet.molbio.ageing:496 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: FWR10 <@UBVM.CC.BUFFALO.EDU:FWR10@PHX.CAM.AC.UK> To: Marshall University Content-transfer-encoding: 7BIT Via: uk.ac.cambridge.phoenix; Thu, 23 Sep 1993 09:36:50 +0100 In the UK we are attempting to produce a subject guide to networked information resources in the biomedical field. I have volunteered to look at the ageing/gerontology area but feel I need a little help! Please will members of this discussion group send me details of info. resources that they are aware of and I will summarize the responses for the list. Thanking you in advance for your help, Wendy Roberts Cambridge University Medical Library, UK email FWR10@phx.cam.ac.uk se From owner-ageing@net.bio.net Thu Sep 23 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!howland.reston.ans.net!darwin.sura.net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: gerritf@HACKTIC.NL (Gerrit Fieret) Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: RE: Info resources Message-ID: <199309230841.AA08904@xs4all.hacktic.nl> Date: 23 Sep 93 08:41:40 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Lines: 44 Xref: biosci bionet.molbio.ageing:497 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: gerritf <@UBVM.CC.BUFFALO.EDU:gerritf@HACKTIC.NL> In-reply-to: <199309230835.AA29637@xs4all.hacktic.nl> from "Wendy Roberts" atSep 23, 93 09:35:33 am To: Marshall University Content-type: text Content-transfer-encoding: 7BIT X-Mailer: ELM [version 2.4 PL21] Content-Length: 1330 X-To: GERINET@UBVM.cc.buffalo.edu Dear Wendy, Probably redundant, but anyway: have you tried Lee Hancock's Internet/Bitnet Health Sciences Resources. The document has been updated last 9-6-1993 and gives a very good list of resources on health care, including geriatric/gerontology. It deals with listserv, ftp, wais, and the like. You can ftp the latest version of this list at ftp.sura.net, in the directory /pub/nic. Look for the file medical.resources.xx-xx, where xx-xx represents the date of release. It's updted 4-5 times a year. Hope to help. (R)egards, Gerrit Fieret > > In the UK we are attempting to produce a subject guide to networked > information resources in the biomedical field. I have volunteered > to look at the ageing/gerontology area but feel I need a little > help! > > Please will members of this discussion group send me details of > info. resources that they are aware of and I will summarize the > responses for the list. > > Thanking you in advance for your help, > > Wendy Roberts > Cambridge University Medical Library, UK > email FWR10@phx.cam.ac.uk > > > se > -- _/_/_/ Gerrit Fieret = gerritf@hacktic.nl _/_/_/ _/ Velddreef 198, 2727 CR Zoetermeer, The Netherlands _/ _/_/_/ tel +31 79 413227 / fax + 31 79 428348 _/_/ _/ All rights reserved / All disclaimers apply _/ From owner-ageing@net.bio.net Fri Sep 24 23:00:00 1993 Path: biosci!rutgers!princeton!phoenix.Princeton.EDU!angelo From: angelo@phoenix.Princeton.EDU (Angelo Gunasekera) Newsgroups: bionet.molbio.ageing Subject: ligation of ~20kb fragment into pUC118/pUC119 Message-ID: <1993Sep24.205055.14342@Princeton.EDU> Date: 24 Sep 93 20:50:55 GMT Sender: news@Princeton.EDU (USENET News System) Distribution: bionet.molbio.methds-regnts Organization: Princeton University Lines: 10 Originator: news@nimaster Nntp-Posting-Host: phoenix.princeton.edu My ealry message under this topic escaped me before typing the message. i am writing this for a friend of mine who needs assistance in cloning a 20 kb fragment into pUC118/pUC119. She had tried this many times w/o succsess. Can anyone out there help her with their expeience in cloning such a large fragment into pUC118/pUC119 (specially isolation of the insert, cloning condions, ratio of insert to vector?). My personal opinion was "it is impossible". Thanks Angelo From owner-ageing@net.bio.net Fri Sep 24 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!spool.mu.edu!darwin.sura.net!RBSE.Mountain.Net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: mmg@CAMIS.STANFORD.EDU (Mary Kane Goldstein) Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: RE: Info resources Message-ID: Date: 25 Sep 93 10:10:29 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Geriatric Health Care Discussion Group Lines: 5 Xref: biosci bionet.molbio.ageing:499 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> Return-path: mmg <@UBVM.CC.BUFFALO.EDU:mmg@CAMIS.STANFORD.EDU> In-reply-to: Your message <9309230837.AA07006@CAMIS.Stanford.EDU> of Thu,23 Sep 1993 09:35:47 BST To: Marshall University Content-type: TEXT/plain; charset=US-ASCII Content-transfer-encoding: 7BIT X-To: Geriatric Health Care Discussion Group In response to Wendy Roberst - as a list member, I very much look forward to seeing the compiled list! Mary Goldstein Stanford University From owner-ageing@net.bio.net Sun Sep 26 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!pipex!uunet!timbuk.cray.com!walter.cray.com!mwd From: mwd@walter.cray.com (Mark Dalton) Newsgroups: bionet.molbio.ageing Subject: Re: How do we age? Message-ID: <1993Sep27.160127.21303@walter.cray.com> Date: 27 Sep 93 21:01:26 GMT References: <1993Sep18.121310.24154@gserv1.dl.ac.uk> Distribution: bionet Lines: 32 Nntp-Posting-Host: snoid.cray.com X-Newsreader: TIN [version 1.2 PL2-CRIa] My understanding is that we already know of 2 mechanisms 1."finite proliferative potential" - limit number of cell divisions dependant on the cell type and the cells differentiation. The more differentiated the cell the less division. 2. The build up of lysosomes (or something regarding lysosomes). It has been to long. Does anyone know more about this? Has this idea changed? Thanks! Mark Sydney Shall (bafa1@uk.ac.sussex.central) wrote: : I believe that Malcolm McMahon has clearly expressed the essential : evolutionary rationale for the "Hayflick" limit, that is the finite : proliferative capacity of most somatic cell types. Primarily, : it is a protection against cancer, because a cell which has been : transformed to morphological or metastatic malignancy, but still has : a finite lifespan will in many circumstances not kill the host. : Sydney SHALL : S.Shall@sussex.central.ac.uk -- Mark Dalton Cray Research, Inc. Eagan, MN 55121 Internet: mwd@cray.com From owner-ageing@net.bio.net Mon Sep 27 23:00:00 1993 Path: biosci!BROWNVM.BROWN.EDU!ST401896 From: ST401896@BROWNVM.BROWN.EDU Newsgroups: bionet.molbio.ageing Subject: Re: How do we age? Message-ID: <9309280511.AA05300@net.bio.net> Date: 28 Sep 93 04:59:56 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 5 I would like to hear people's opinions or speculations on the underlying mechanism for the Hayflick limit. What is it in the cellular machinery that limits cell the number of cell divisions? Well, presumably the limit is ultimately set by a gene gone kaput, but does this happen gradually or all of a sudden? From owner-ageing@net.bio.net Wed Sep 29 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!warwick!not-for-mail From: cuhes@csv.warwick.ac.uk (Malcolm McMahon) Newsgroups: bionet.molbio.ageing Subject: Re: How do we age? Message-ID: <28era8$hco@violet.csv.warwick.ac.uk> Date: 30 Sep 93 14:43:20 GMT References: <9309280511.AA05300@net.bio.net> Distribution: bionet Organization: Computing Services, University of Warwick, UK Lines: 22 NNTP-Posting-Host: violet.csv.warwick.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=US-ASCII Content-Transfer-Encoding: 7bit In article <9309280511.AA05300@net.bio.net>, ST401896@BROWNVM.BROWN.EDU writes: >I would like to hear people's opinions or speculations on the >underlying mechanism for the Hayflick limit. What is it in the >cellular machinery that limits cell the number of cell divisions? >Well, presumably the limit is ultimately set by a gene gone kaput, >but does this happen gradually or all of a sudden? We had some discussion of this some months ago on sci.nanotech. Someone claimed that a mechanism had been found. To be specific that the end sequence of certain cromosomes, called telomeres if I remember correctly, are incompletely replicated, each generation losing a few bases. After a certain number of generations the redundant DNA is used up and real genes start to be erroded. Apparently there is a special enzyme mechanism that replaces these terminal repeats in germ cells. Now I can't actually vouch for this and I don't have any references but it sounds reasonable. Of course it also sounds very hopeful. It may be that if you could regenerate these telomeres every thirty years or so you might defeat the primary ageing mechanism. Such treatement would bring a risk of cancer. Malcolm McMahon From owner-ageing@net.bio.net Thu Sep 30 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!pipex!uunet!munnari.oz.au!uniwa!newsman!Jim.Cummins From: cummins@possum.murdoch.edu.au (Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: ACE inhibitors and ageing. Message-ID: <28htioINN9pg@newsman.csu.murdoch.edu.au> Date: 1 Oct 93 18:40:24 GMT Sender: -Not-Authenticated-[6576] Organization: Murdoch University, Western Australia Lines: 12 NNTP-Posting-Host: vetmac3.csu.murdoch.edu.au X-Posted-From: InterNews 1.0@newsman.csu.murdoch.edu.au. Xdisclaimer: No attempt was made to authenticate the sender's name. A recent report (Ferder et al Am J Physiol 265: 15C, 1993) found that administration of ACE inhibitors to mice resulted in improved survival, lower incidence of renal and cardiac sclerosis, and increased numbers of cardiac and hepatic mitochondria. Anyone on the net know of links between the renin/angiotensin system, free radical release and mitochondrial function? Jim Cummins School of Veterinary Studies Murdoch University Western Australia 6150 Tel +61-9-360 2668 Fax +61-9-310 4144 For every complex problem there's a simple solution. And it's wrong! From owner-ageing@net.bio.net Thu Sep 30 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!spool.mu.edu!uwm.edu!math.ohio-state.edu!darwin.sura.net!RBSE.Mountain.Net!wvnvms.wvnet.edu!marshall.wvnet.edu!newsmgr From: goes@CHIMERA.SPH.UMN.EDU (Jim Goes) Newsgroups: bionet.molbio.ageing,bit.listserv.gerinet Subject: Announcing HEALTHMGMT Message-ID: <199309292044.AA04414@chimera.sph.umn.edu> Date: 29 Sep 93 20:44:30 GMT Sender: Geriatric Health Care Discussion Group Reply-To: Jim Goes Organization: School of Public Health, University of Minnesota Lines: 104 Xref: biosci bionet.molbio.ageing:504 To: IN%"NEWSMGR@muvms6.wvnet.edu" "Marshall University" CC: Return-path: <@UBVM.CC.BUFFALO.EDU:owner-gerinet@UBVM.CC.BUFFALO.EDU> To: Marshall University Content-transfer-encoding: 7BIT X-To: ADMIN-L@ALBNYDH2.BITNET, AHL@GWUVM.BITNET, AMIA-37@UMAB.BITNET,FAMILY-L@MIZZOU1.BITNET, GERINET@UBVM.BITNET, MEDNEWS@ASUACAD.BITNET,MHCARE-L@MIZZOU1.BITNET, MINHLTH@DAWN.HAMPSHIRE.EDU, NEURL@UICVM.BITNET,SHS@UTKVM1.BITNET, SPHALB-L@ALBNYDH2.BITNET Announcing HEALTHMGMT ------------------------------------- An Internet Discussion list for Health Care Management and Administration HEALTHMGMT is the Internet discussion forum for those interested in the practice, research, and education of management in health care and health service organizations. Discussions on issues pertaining to the management and administration of all health-related organizations, including hospitals, health systems, HMOs, nursing homes, health care networks, etc., and ebates about current issues and events in health care and their impact on health care organizations and research are all welcomed. Management practitioners, researchers, and educators interested in health care issues are all encouraged to participate. Enrollment is open to anyone interested in these issues. HEALTHMGMT is also the electronic discussion list for the Health Care Administration Division of the Academy of Management. 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If you prefer to receive a periodic summarized digest of messages posted on HEALTHMGMT, rather than receive individual messages directly, you may subscribe to HEALTHMGMT-D@chimera.sph.umn.edu (using the same method as above). Do not subscribe to both lists. Welcome to this new electronic community for practitioners, researchers and educators in health care management. If you have any questions, problems, or suggestions feel free to contact the us. HEALTHMGMT is operated by the Division of Health Management and Policy, School of Public Health, University of Minnesota (also home of the MANAGEMENT ARCHIVE). List manager is Jim Goes (goes@chimera.sph.umn.edu). -- *************************************************************** Jim Goes + InterNet: goes@chimera.sph.umn.edu Health Management & Policy + (NeXTmail welcome!) School of Public Health + Phone: (612) 624-3118 University of Minnesota + FAX: (612) 624-3972 --------------------------------------------------------------- Home of HEALTHMGMT discussion list and The Management Archive *************************************************************** Recessive jeans: denim pants that shrank in the wash