From owner-ageing@net.bio.net Sat Jul 01 23:00:00 1995 Path: biosci!rutgers!gatech!howland.reston.ans.net!xlink.net!nntp.gmd.de!news.rwth-aachen.de!news.rhrz.uni-bonn.de!news.uni-stuttgart.de!news.belwue.de!News.Uni-Marburg.DE!usenet From: Andreas Becker Newsgroups: bionet.molbio.ageing Subject: Mitochondria WWW site Date: 2 Jul 1995 11:39:20 GMT Organization: FB Chemie/Biochemie, Phillips-Universitaet, D-35039 MARBURG Lines: 16 Message-ID: <3t60h8$6fd@surz03.HRZ.Uni-Marburg.DE> NNTP-Posting-Host: nnex08.ppp.uni-marburg.de Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Windows; I; 16bit) Is there any site with the topics: mitochondria mitochondria and aging I want to build up a www site where I will mention that topics. If any one know a www site please tell me. ---------------------------------------------------------------------- Andreas Becker Arbeitskreis Prof. Kadenbach, FB Chemie/Biochemie, Hans- Meerwein-Strasse, Philipps-Universitaet, 35043 Marburg, Germany Phone: privat +49 6421 47304 Labor +49 6421 28 -5721 Fax -2191 eMail: BECKER@ps1515.Chemie.Uni-Marburg.De WWW : http://www.chemie.uni-marburg.de/~becker From owner-ageing@net.bio.net Sun Jul 02 23:00:00 1995 Path: biosci!POSSUM.MURDOCH.EDU.AU!cummins From: cummins@POSSUM.MURDOCH.EDU.AU (Dr Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Re: Mitochondria WWW site Date: 2 Jul 1995 17:39:10 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 23 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net >Is there any site with the topics: >mitochondria >mitochondria and aging > >I want to build up a www site where I will mention that topics. >If any one know a www site please tell me. Try gopher://megasun.bch.umontreal.ca:70/11/Organelles http://www.hookup.net/mall/aging/agesit59.html Jim "Spermatology rules o~ o~ o~ o~" Cummins Associate Professor in Veterinary Anatomy Murdoch University, Western Australia 6150 Tel +61-9-360 2668, Fax +61-9-310 4144 E mail URL "An inordinate fondness for Beetles" (Haldane on God). From owner-ageing@net.bio.net Tue Jul 04 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!news.sprintlink.net!gatech!newsjunkie.ans.net!Rezonet.net!titane!comback!nntphost!comback!chatterbox.login.net!doctor_godless Newsgroups: bionet.molbio.ageing Message-ID: <1554@chatterbox.login.net> Reply-To: doctor_godless@chatterbox.login.net (DOCTOR GODLESS) From: doctor_godless@chatterbox.login.net (DOCTOR GODLESS) Date: Wed, 05 Jul 1995 06:05:00 GMT Subject: Re: Searching Lines: 12 I would also like a copy. Please send me one at: Doctor_godless@chatterbox.login.net It would be much appreciated. I don't want to bother Dr. Post if I can avoid it. Thanks in advance. Doc ... There's nothing to fear except nothing itself. -Wagschal ___ Blue Wave/QWK v2.12 From owner-ageing@net.bio.net Wed Jul 05 23:00:00 1995 Path: biosci!RESUNIX.RI.SICKKIDS.ON.CA!shah From: shah@RESUNIX.RI.SICKKIDS.ON.CA Newsgroups: bionet.molbio.ageing Subject: cell-death meeting Date: 6 Jul 1995 10:43:40 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 17 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Hi, I am a PhD graduate student in yeast genetics and very close to graduation. I have decided that I would like to pursue the field of programmed cell death for my Post Doc and hopefully future career. I would love to be able to go to a cell-death meeting this year to familiarize myself with the field and get to know the people in the field. I know that there is a Cold Spring Harbour meeting coming in September, but I am told that it would be difficult to attend the meeting since I don't belong to a cell-death lab. Do you have any advice for me as to how I can attend this meeting, whether there are any other meeting that I might go to that is not as restricted and equally informative. I thank you in advance for your help and suggestions. Sherry shah@resunix.ri.sickkids.on.ca From owner-ageing@net.bio.net Wed Jul 05 23:00:00 1995 Path: biosci!FREENET.TORONTO.ON.CA!bk772 From: bk772@FREENET.TORONTO.ON.CA (Dmitri Chamchad) Newsgroups: bionet.molbio.ageing Subject: pathology/histology job need Date: 6 Jul 1995 12:27:49 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 112 Sender: daemon@net.bio.net Distribution: world Message-ID: References: NNTP-Posting-Host: net.bio.net My name is Dmitri Chamchad , I'm doctor of medicine. I had working several years on the problem of aging. I searched especially aging of spermatogenic cells in mail gonads, comparison between Youngest and oldest models. I search intercellular interaction between Leudig cells, Sertolly cells and spermatogenic layer. I did find conformity to natural laws in aging process of male gonads, and as result - method of treatment male sterility syndrome. If You can help me by any way , I'll be very grateful. R E S U M E SUMMARY OF QUALIFICATION - selection tissues for analysis; different methods of tissue preservation; preparation of tissues for examination by ultratome and microtome; - DNA molecular Biology: Isotope or DIG labeling DNA probes. Southern, Northern, and Western blots analysis. - tissue culture: Mammalian cell culture. Specimen preparation and operation for SEM and TEM. - chemical methods of tissue colouring using different stains as haematoxylin and eosin dye, Sudan IV, Feulgen's reaction, argentum impregnation; fluorescent stains and fluorescent antibodies; processing tissues using enzymes ( Dnase, RNase, Phosphothase etc); immunologic method of labeling antibodies; - quality analysis of microscopic cells, tissues and cells identification, morphometry, computerized analysing tissues; - computer software: Word Perfect; Microsoft Excel, Words, Works, Windows; programming in Visual Basic, Fortran. WORK EXPERIENCE 11.1986 Histologist. Department of Histology and Embryology of 06.1990 Medical University, Moscow, Russia. 11.1990 Histologist. M.P. "Medinform" 06.1992 Moscow, Russia. EDUCATION 09.1985 Russian Medical University, Moscow, Russia, 02.1992 Paediatric Department. Degree, Medical Doctor. 09.1980 Moscow Medical College 07.1982 Diploma, Registered Nurse LIST OF PUBLICATIONS 1. V.S.Sukhorukov, D.A.Chamchad "definition of spermatogenic layer maturity level in rats during regeneration or during intact testicular development" in Archives of AHE-Society [Archives of Anatomy, Histology and Embryology], 1989, N9, pp 88-91 2. V.S.Sukhorukov, S.B.Tarabryn, D.A.Chamchad "Use of Sertoli -cells-only syndrome model for investigation of some gonadal development regularities in "Actual Problems of Medical Embryology" Siberian Depart. of Medical Academy, AHE-Society, Irkutsk, 1989 3. V.S.Sukhorukov, S.B.Tarabryn, I.A.Darenkov, A.A.Dreval, O.V.Volkova, A.K.Polonsky, D.A.Chamchad "Way for male sterility treatment" Patent request N 48248664/14, priority of May 29,1990 4. V.S.Sukhorukov, S.B.Tarabryn, D.A.Chamchad "Postnatal SCO-syndrome in rats as a model of paracrine regulation and regeneration research" 4th Int. Congr. on Vertebrates Biol. 1992 Moscow 5. O.V.Volkova, S.B.Tarabryn, S.B.Sukhorukov, D.A.Chamchad "Paracrine regulation in male gonads. I. Interactions between somatic gonadal components." Archives of AHE-Society 1992 6.O. V.Volkova, S.B.Tarabryn, V.S.Sukhorukov, D.A.Chamchad "Paracrine regulation in male gonads. II About the possibility of germ cells influence on somatic microenvironment" Archives of AHE-Society in press. OTHERS Permanent resinent of Canada REFERENCES (can be send by request): 1. Chief of Department of Histology and Embryology of Russian Medical University, Member of Medical Academy D.M. prof. Olga V. Volkova Moscow, Ostrovitanova str. Building N1 Department of Histology and Embryology tel.(095)-434-4192; 2. Scientific Chief M.D. Ph.D. Docent. Sergey B. Tarabryn Moscow, Ostrovitanova str. Building N1 Department of Histology and Embryology tel.(095)-442-6323 (095)-434-5534 3. General Director M.P. "Medinform" Victor I. Shustov Moscow, Bolotnikovskay str.41-96 tel.(095)-433-0520 Dmitri Chamchad 715 Finch ave. west, apt.904 Downsview, Ontario, M3H 4X7, Canada. tel. (416)-398-5947 e-mail: bk772@freenet.toronto.on.ca From owner-ageing@net.bio.net Thu Jul 06 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!europa.chnt.gtegsc.com!news.umbc.edu!haven.umd.edu!purdue!mozo.cc.purdue.edu!not-for-mail From: barani@mace.cc.purdue.edu (Barani) Newsgroups: bionet.molbio.ageing Subject: AGEING of Cells vs Organisms Date: 7 Jul 1995 11:26:39 -0500 Organization: Purdue University Lines: 21 Message-ID: <3tjn7v$qmp@mace.cc.purdue.edu> NNTP-Posting-Host: mace.cc.purdue.edu AGEING of an Organism is different from AGEING of individual cells. Sometimes faster AGEING of cells may mean a slower AGEING of the organism. For example, older cells should be destroyed in an organism as fast as possible and replaced with newer young cells. Otherwise older cells can lead to cancer. For the organism AGEING can be counted based on markers that are breakdown-points in metabolic pathways. Some critical breakdowns lead to visible changes in the organism like greying of hair. Barani Lilly Hall of Life Sciences Purdue University | | | | | ----- ----- ----- ----- ----- | | | | | ================================================================ | This box is dedicated to the memory of those who spent their| | Lifetimes on the AGE-OLD problem of the OLD-AGE problem. | ================================================================ From owner-ageing@net.bio.net Thu Jul 06 23:00:00 1995 Path: biosci!SINGER.ASRI.EDU!MANEV From: MANEV@SINGER.ASRI.EDU Newsgroups: bionet.molbio.ageing Subject: REGISTRATION IS IN PROGRESS FOR APOPTOSIS SYMPOSIUM Date: 7 Jul 1995 04:52:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 7 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net International Symposium on Oxidative Stress, Apoptosis and Brain Damage will be held in Pittsburgh, PA from September 21 to 24. Registration is in progress ($ 250, three days; includes course materials, welcome reception, continental breakfast, lunch and refreshment breaks each day). For information please call: +412-359-4952. From owner-ageing@net.bio.net Thu Jul 06 23:00:00 1995 Path: biosci!galaxy.ucr.edu!library.ucla.edu!agate!overload.lbl.gov!lll-winken.llnl.gov!enews.sgi.com!decwrl!waikato!auckland.ac.nz!kcbbs!planet!chambers!steve From: steve@chambers.ak.planet.co.nz (Steve Chambers) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: Needed:Information about aging and death of organisms (human, animals) Message-ID: Date: Fri, 7 Jul 95 17:43:41 +1200 References: Organization: PlaNet (Auckland New Zealand) Lines: 80 Xref: biosci bionet.molbio.ageing:1846 sci.life-extension:6021 In Anne.Lilie@extern.uni-ulm.de (Anne Lilie) writes: >Hello, Hi Anne This is quite a shopping list of questions! And I hope it'll stimulate some discussion for you. I'll (I hope) start the ball rolling by answering them as succinctly as I can. >-What exactly happens when an organism ages? It varies from organism to organism, and for each organism there are a _huge_ number of changes associated with aging. >Does the metabolism slow down, Usually, but there's no reason for us to _assume_ that that's a bad thing. Indeed, there are many reasons to think that a reduced metabolism may be beneficial. >and therefore reduces the intake of oxidation and water (which leads to >hydration of the skin etc..)? >-And why does the organism loose water (newborn 90% but adult 80%)? I imaging that this is largely a function of increased fat %, rather than anything else. However, connective tissue Xlinking and general conn. tiss. disorder may be a factor. >-Why do some people age later and some sooner? Variability in biological function is the norm - rather than the exception. >Is the "aging clock" build in the cell? There is certainly some form of clock in most cells which influences the aging (or more correctly the cellular senescence) of those cells. Whether this has any influence on the aging of whole organisms has yet to be determined. >-Are all tissues (cells) affected? No - at least not significantly so within the lifetime of any multicellular organisms that I'm aware of. >Where (in which cells) does the aging process start? Or does it start >gradually? Aging is an amalgam of many processes. Some of them start the moment a cell comes into existence. >Are only certain tissues affected? Effects to only some tissues have so far been shown to influence age- dependant mortality. >-During the aging process, how do the molecules react and in which way do >they change their composition? Aging processes are many and varied. Some of the more important "molecule changing" agents are; reactive oxygen species and other free radicals, glycosylation and other crosslinking reactions. >-What is death? During the aging process have the molecules changed >gradually, that in the end, they just cant react anymore or very little >with each other, and then just start falling apart (causing the organism, >to get less and less resistant to illness...)? >Thank you, waiting for your answers, I've crossposted this to bionet.molbio.ageing and sci.life.extension. Check these newsgroups out - these matters are discussed regularly there. Steve -- ________________________ (I_lurk,_therefore_I_am!_\ ,,, Steve Chambers (o o) steve@chambers.ak.planet.co.nz -----------------------oOO--(_)--OOo------------------------------------ From owner-ageing@net.bio.net Thu Jul 06 23:00:00 1995 Path: biosci!rutgers!uwm.edu!vixen.cso.uiuc.edu!howland.reston.ans.net!usc!chandler.hsc.usc.edu!user From: hutchin@hsc.usc.edu (Tim Hutchin) Newsgroups: bionet.molbio.ageing Subject: Re: Aging or Ageing? Date: Fri, 07 Jul 1995 09:28:21 +0000 Organization: University of Southern California Lines: 9 Sender: hutchin@chandler.hsc.usc.edu Distribution: world Message-ID: References: <3tjjt2$36k@ixnews7.ix.netcom.com> NNTP-Posting-Host: chandler.hsc.usc.edu In article <3tjjt2$36k@ixnews7.ix.netcom.com>, "Lawrence C. Chen" wrote: > Isn't the correctly spelling "AGING"? Only if you're American. The correct English spelling is ageing. -- From owner-ageing@net.bio.net Thu Jul 06 23:00:00 1995 Path: biosci!rutgers!uwm.edu!vixen.cso.uiuc.edu!howland.reston.ans.net!ix.netcom.com!netnews From: "Lawrence C. Chen" Newsgroups: bionet.molbio.ageing Subject: Aging or Ageing? Date: 7 Jul 1995 15:29:38 GMT Organization: Netcom Lines: 2 Distribution: world Message-ID: <3tjjt2$36k@ixnews7.ix.netcom.com> NNTP-Posting-Host: ix-ir16-03.ix.netcom.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.2b2 (Windows; I; 16bit) Isn't the correctly spelling "AGING"? From owner-ageing@net.bio.net Fri Jul 07 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!news.starnet.net!wupost!waikato!auckland.ac.nz!kcbbs!planet!chambers!steve From: steve@chambers.ak.planet.co.nz (Steve Chambers) Newsgroups: bionet.molbio.ageing Subject: >Aging or Ageing? Message-ID: Date: Sat, 8 Jul 95 10:31:01 +1200 References: <3tjjt2$36k@ixnews7.ix.netcom.com> Organization: PlaNet (Auckland New Zealand) Lines: 18 In <3tjjt2$36k@ixnews7.ix.netcom.com> "Lawrence C. Chen" writes: >Isn't the correctly spelling "AGING"? Writers of English english tend to use "ageing" while those of American english tend to use "aging". Either is correct according to the Oxford Dictionary. I use "aging" because it's used five times more frequently in scientific literature. (Do a medline search using both and you'll see what I mean.) Common usage is the mother of language. Steve -- ________________________ (I_lurk,_therefore_I_am!_\ ,,, Steve Chambers (o o) steve@chambers.ak.planet.co.nz -----------------------oOO--(_)--OOo------------------------------------ From owner-ageing@net.bio.net Fri Jul 07 23:00:00 1995 Path: biosci!POSSUM.MURDOCH.EDU.AU!cummins From: cummins@POSSUM.MURDOCH.EDU.AU (Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Re: >Aging or Ageing? Date: 7 Jul 1995 19:21:34 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 8 Sender: daemon@net.bio.net Distribution: world Message-ID: References: NNTP-Posting-Host: net.bio.net Who cars? Dr Jim Cummins +61-9-360 2668 School of Veterinary Studies FAX =61-9-310 4144 Murdoch University cummins@possum.murdoch.edu.au Murdoch, Western Australia 6150 "For every complex problem there's a simple solution. And it's wrong!" From owner-ageing@net.bio.net Fri Jul 07 23:00:00 1995 Path: biosci!ns1.faseb.org!darwin.sura.net!www.uno.edu!uno.edu!KGPL From: kgpl@uno.edu Newsgroups: bionet.molbio.ageing Subject: Free Radicals in Cell Nuclei? Date: 8 Jul 1995 09:12:31 GMT Organization: University of New Orleans Lines: 10 Message-ID: <3tli5v$utc@www.uno.edu> Reply-To: kgpl@uno.edu NNTP-Posting-Host: jazz.ucc.uno.edu Someone has suggested to me that a lot of age-related damage may be the result of accidental miscopying of DNA due to the presence of free-radicals in cell nuclei messing up the copying process. Is this possible? What kinds of free-radicals are generated within, or can get into, the nucleus of a cell? Is there any reason to suspect that this sort of damage is more likely to occur during the process of cell division? Thanks, Kevin From owner-ageing@net.bio.net Fri Jul 07 23:00:00 1995 Path: biosci!biosci!not-for-mail From: agerus95@glas.apc.org (Vitaly I. Dontsov) Newsgroups: bionet.cellbiol,bionet.molbio.ageing Subject: Information Bulletin of Foundation of Life prolongation Date: 8 Jul 1995 08:31:38 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 888 Sender: kristoff@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Xref: biosci bionet.cellbiol:2536 bionet.molbio.ageing:1854 ******************************************* * * * A G E and L O N G E V I T Y * * * ******************************************* INFORMATION BULLETIN of FOUNDATION for LIFE PROLONGATION Vol.5 MOSCOW RUSSIAN FEDERATION E.MAIL: agerus95@glas.apc.org ( in GlasNet ) E.MAIL CONFERENCE: AGEING&LONGEVITY.BIOMED.NEWS(RUS) in brief: ageing.biomed ( in GlasNet ) Tel.(095) 903-16-40, 365-05-25( Foundation for life prolongation ) (095) 903-16-40 ( Clinical consulting Center ) (095) 365-03-25, 365-05-25 ( Scientific researches ) For correspondence: prof. Podkolzin A.A., D.M., Academician of New York Academy of Science, Director of Central scientific research laboratory, MOSCOW medical Stomatological Institute ( or Vitaly I.Dontsov, M.D. ) Moscow, 103473, Delegatskaja str., 20. Russian Federation Fax.(095) 973-32-59 Tel.(095) 365-05-25, 365-03-25 --------------------------------------------------------------------------- - 2 - CONTENTS: About the Foundation for Life Prolongation ............................. 3 Programme of The first Russian conference "Medical and biological aspects of normal and pathological aging"........................... 4 Brief communications and thesises of reports of The first Russian conference "Medical and biological aspects of normal and pathological aging"................................................. 7 Foundation of life prolongation present original scientific reports:.....19 Foundation of life prolongation present original scientific projects:....21 New complex scientific-research programme "New biological and physical methods in diagnostics and treatment of tumours"....................24 --------------------------------------------------------------------------- - 3 - FOUNDATION for LIFE PROLONGATION Scientific non-state organization, which carry out coordination, realization and financing investigations in Biology of Aging and Life Prolongation, new and ancient methods for creative realization and self-improvement of individuals, new methods of biostimulation, bioactivation and rejuvenation. Scientific researches from Russian Academy of Sciences, Academy of Medical Sciences and Ministry of Health participates in our programs. FUND CARRY OUT: Coordination of complex investigation programs in fundamental and clinical assay in biology of aging and the life prolongation. Organization of conferences and meetings. Publicize books, reports, prepare computer programs. Leading scientists in Biology of Aging and Life Prolongation present lectures and reports. Organization of working-outs, production and marketing of special devices and methods . Realization of East and Ancient health courses, which help to make creative realization and self-improvement of individuals. Accomplishing other measures in Biology of Aging and Life Prolongation. Tel.(095) 903-16-40, 365-05-25( Foundation for life prolongation ) (095) 903-16-40 ( Clinical consulting Center ) (095) 365-03-25, 365-05-25 ( Scientific researches ) For correspondence: prof. Podkolzin A.A., D.M., Academician of New York Academy of Science, Director of Central scientific research laboratory, MOSCOW medical Stomatological Institute ( or Vitaly I.Dontsov, M.D. ) Moscow, 103473, Delegatskaja str., 20. Russian Federation Fax.(095) 973-32-59 Tel.(095) 365-05-25, 365-03-25 --------------------------------------------------------------------------- - 4 - INFORMATION of FOUNDATION for LIFE PROLONGATION About: THE FIRST RUSSIAN CONFERENCE "MEDICAL AND BIOLOGICAL ASPECTES OF NORMAL AND PATHOLOGICAL AGING" ( 23-24 November, 1993, Moscow ) Institute of chemical physic of Russian Academy of Science Moscow seciety of Nature researchers of Moscow State University Foundation for Life prolongation, International association "FENIX" Central research laboratory of Moscow medical stomatologocal institute I SECTION:"FUNDAMENTAL MECHANISMS OF AGING". 1.Surmounting of the species barier of human lifestrategical problem of its radical prolongation. Vischev I.V., D.Ph. 3.Fundamental mechanisms of aging, it general types and mechanisms. Dontsov V.I., M.D. 4.The problems of aging and mortility of high organisms and Darvin natural selection theory. Akifjev A.P., Ph.D. 5.The nature of organism ageing process. Muhankin A.I., Ph.D. 6.The systems of life longivity determination. Gubanov E.A. 7.Humans manifests the potentially non-aging properties.Haljavkin A.V. 8.Gene-immortalised effects on cell mitosis and differentiation regulation, aging and programmed cell wreck. Haljavkin A.V., Ph.D. 9.DNA secondary structure defects, recognited by S1 nuclease and its probable role in somatic mammalians cells aging.Potapenko A.I.,Ph.D. 2.Mathematical model and whole graphic of age mortility, its probable physiological sense and new immunological theory of aging.Dontsov V.I. 10.Epygenetic structurization of biosystems time and new forms of DNA memory. Garjaev P.P.,Ph.D. 11.Wave mechanisms of gene regulation and its role in cell age correction. Chirckova E.N., Ph.D. 12.Embrion hypothalamic transplantation as method of organism develop- ment programm correction. Ata-Muradova F.A.,Ph.D., Dontsov V.I.,MD 13.About possible artificial life prolongation by"gene cycling" me- thods. Isaev N.N. 14.Mathematical models of mortility graphics. Poltorakov A.P. 15.Age-dependent mortility from leukosis: effects of radiation and age. Mamaeva E.F., Ph.D. 16.The biological effects of age age-increasing mortility. Mamaev V.B. 17.Biorhytmes as probable regulator mechanism of life term.Bakaev V.V. --------------------------------------------------------------------------- - 5 - II SECTION: "CLINICAL AND PHYSIOLOGICAL RESEARCH AND BIOSTIMULATION". 1.Theory, physico-chemical and biological basis of "agents of low intensivity" effects. Podkolzin A.A., M.D. 2.Mechanisms of "agents of low intensivity"effect: resonanse stimulation immune antibody production in mice by the use of low intensivity pulse current. Barysheva A.V., M.D., etc. 3.Immunomodulation effects of low intensivity magnetic field on immune antibody production in mice. Dontsov V.I., M.D. 4.The new method of function and bioenergetic diagnosis, treatment and bostimulation by the original electroacupuncture without external currents. Makaz V.G., M.D. 5.Device and patented method of tumour diagnosis by spectrofluorescence. Makaz V.G., M.D. 6.New properties for effects on free-radical mechanisms of aging by electrochemical ativated systems. Podkolzin A.A., M.D. etc. 7.Genetics aspects of artificial life prolongation prolem. Borisov S.E. 8.Analysis of some effective methods of life prolongation: hypobiosis as perspective method for life prolongation in mammalians. Chernilevsky V.E., Ph.D. 9.About effects of some phyto-extracts on development and life term in plants. Aleutsky N.N.,M.D. 10.New effective phyto-microelement and homeopathic complexes. Shepelenko A.M. etc. 11.Adaptation as method for regulation of aging process in man. Muhankin A.I., Ph.D. 12.About some indexes in the measuring of human aging rate. Verchotin M.A., Ph.D. 13.The principle of minimum energy in ontogenesis and age bioenergetic problems. Ozernuk N.D.,Ph.D. 14.About effects of age on activity of enzymes of lipids and DNA methabolism. Romanenko E.B. 15.Neuro-phisiological aspects in the measuring of human aging rate. Novoselov V.M. 16.Analysis of energy-producing systems regulation mechanisms and methods for its measuring. Pospelov A.A., M.D. 17.Some aspects of the mathematical models of human aging rate measuring. Zajarny A.N. --------------------------------------------------------------------------- - 6 - 18.Homeopathical profilaction of aging. Sluzkin N.I.,M.D. 19.About low temperature effects on life term of some vermics.Bakaev V.V. 20.Depression in age and problems in surmounting of resistance to remedies. Bujkov V.A., M.D. 21.Selenium concepts of decreasing man supermortility in Finland. Anuphriev A.D. 22.New opportunities of weak bioelectrocurrents and non-ionizing radi- ation in diagnosis, treatments and age biostimulation. Dontsov V.I. III SECTION: HISTORY OF GERONTOLOGY, SOCIAL ASPECTS, ANCIENT EAST METHODS OF LIFE PROLONGATION. 1.Term of life and its secret. Belova T.A., Ph.D. 2.Life prolongation as a science. Tuev V.A., Ph.D. 3.About creation of National Institute of Health and Life Prolongation. Vishev I.V., Ph.D. 4.About centers of life prolongation.Ananjev V.M,Ph.D. 5.The working expirience of life prolongation center "Anastasis". Bogolubova L.G., Ph.D., etc. 6.Mathematical models of effects of social and psychical factors on human aging. Judasin L.A. 7.Psychotherapy as prophylactic factor on patients with cerebral atherosclerosis. Grigorjevskich V.S.,MD 8.Energy self-organization in cell and energy interaction in organism. Fofanov S.I. 9.General methodology of East and Ancient esoteric ( secret ) knowledge and psychotechnics. Dontsov V.I., MD --------------------------------------------------------------------------- - 7 - BRIEF COMMUNICATIONS AND THESISES OF REPORTS of THE FIRST RUSSIAN CONFERENCE "MEDICAL AND BIOLOGICAL ASPECTS OF NORMAL AND PATHOLOGICAL AGING" FUNDAMENTAL MECHANISMS OF AGING FUNDAMENTAL MECHANISMS AND TYPES OF AGING. Dontsov V.I., MD Central scientific research laboratory, MOSCOW medical Stomatological Institute. Moscow,103473, Delegatskaja str.,20. Russian Federation Fax. (095) 973-32-59 Tel.(095) 365-03-25, 365-05-25 Original theoretic and experimental reports about the computer models of sells-renovation processes in mammalians, which can make possible obtaining the whole graphic of age mortality and to speculate about probable physiological sense of it. Theoretical presentation of 4 principal , general types of aging and special role of the critical part for mammalians aging mechanism - reduction of self tissues renovation; special models of its regulation mechanisms in mammalians and humans especially. Here is completely new lymphoid theory of aging, based on the new lymphocytes function - its ability to regulate growth of different cell types. Theoretical, mathematical models, special bibliography and original experimental studies illustrate: regeneration of different tissue and specially lymphocyte function decline with age, what is equivalent to the reduction of cells renovation. The commercial products for research, education and advertisement may be elaborated. --------------------------------------------------------------------------- - 8 - MATHEMATICAL MODEL WHICH MAKE IT POSSIBLE TO OBTAIN THE WHOLE DIAGRAM OF AGE MORTALITY AND ITS PROBABLE PHYSIOLOGICAL SENSE. Dontsov V.I., MD The general cybernetic point of view on the biological systems have shown two principle mechanisms of its structure (state) steadfastness during the time: a) by the formation of nonregenerated units ( teeth, nefrons, nerve cells, non-reparated DNA sites etc. ), b) by the dynamic balance of self-renovated units ( metabolism of biomolecules, cell regeneration of skin, liver and other internal organs, regeneration of some tissues and organs etc. ). The non-regenerated units existence in mammalians and other contemporary intricated organisms is the result of some impotent special processes ( for example, the information storage in mind or in DNA-genes ) and the result of high natural animal mortality when the age period of life have not any evolution significance. These situation leads to the fundamental mechanism of age: the numbers decreasing during time of the non-renovated molecules, cells, organs etc.( because of limiting existence probability of every separate units ) and increasing of mutants units with low functional power ( because for more probable unfavorable results of mutation ). For self-renovated units 3 principle processes exist: 1)self-regeneration (metabolism, cell mitosis, tissue regeneration etc.), 2)fatal case for some units ( and elimination from system ) and 3)mutation of some units ( without elimination from system but it leads to decreasing of system effectiveness ). --------------------------------------------------------------------------- - 9 - The mathematical model of these processes is: dA/dt = c*A/(c1*A + c2 ) - k1*A - k2*A dmA/dt = c3*mA/(c4*mA + c5) - k3*mA + k2*A where A and mA - the number of normal and mutant units, that self-renovation is depended on self-number ( the positive feedback ) and is limited with self-number ( the negative feedback, for example chalone mechanism ). The number decreasing of normal units is depended on its fatal cases and mutation, for mutated units - only fatal cases. "C" and "k" are coefficients that may vary due to balance of deferent regulator factors of organism, that leads to dynamic balance of self-renovated systems. Everybody can see by use the computer models the self-formation of dynamic balance of self -renovated system that is described with formula 1 and time-depended elimination of non-renovated units. The necessary terms for balance are k1 < k3 ( normal units must be more steady than mutants that is realistic ). System is unsteady to tumor growth (negative feedback lack ), but it is not mechanism of aging. As result of co-existence of renovated and not units its interactions exist also. If regeneration level of self-renovated units is depended on non-renovated units number, the age-period during ontogenesis must be exist. The cause of this situation may be the processes of organism growth and its limitations during ontogenesis. The mammalians mechanisms of reproduction needs in period of organism growth and in its limitation mechanisms due to gravitation barrier and food-dependence of growth. As self-renovation may exist without general mass growth, not general growth limitation mechanisms, but special TYPE of growth limitation leads to age period in mammalians. It is clear that self-renovation mechanism have not any internal tendency both growth and degradation but only for dynamic balance in time. The result of renovatednon-renovated units interaction, unlikely, have these time-depended mechanisms. --------------------------------------------------------------------------- - 10 - We propose the next general theory of growth regulation in organism with period of aging. Let level of renovation in multicellular organism ( and general organism mass as its function ) be depended on concentration of some stimulated renovation ( for example enhancing coefficient "c" in formula 1 ) factor "F" - the product of special positive regulator cells "D". For time-depended growth during some years it is necessary the positive F-factor gradient. The well-known biological mechanism for this situation realization is time-dependent natural death of negative regulator cells "I": the balance D - I = F is resulting in stimulation of growth or its restriction. If "D" cells is renovated, growth is limited but there is no any period of system degradation ( period of aging); if the "D" cells is non-renovated,there is period of aging as result of decreasing of "D" cells number due to formula 2: dD/dt = - Kd*D , dI/dt = -Ki*I ,( Kd < Ki). The general curve of time-depended renovation change and its depended age mortality have shown on Fig.1. The age mortality is presented as log ( 1/F ) due to general theory of aging as decreasing of "general vitality" ( as function of "F" ). Anyone may see the well coincidence of theoretical curve and any experimental and demographic real age mortality curves. This results is coincident with regulator group theory of aging and show the main mechanism of aging - the decreasing of renovation level of different regenerated units in organism. The results of its is mass decreasing during the age, the increasing of time, needs for renovation of deferent regenerated units, the increasing of mutants units and other all well known symptoms of age. The specific morphological substrates may be - regulator non-renovated cells of hypothalamus, deferent growth factors in blood; for peripheral mechanisms - proliferated cells and mechanisms of its regulation, especially, some types of lymphocytes, that regulate proliferation of somatic cells. We have shown the existence of special lymphoid system, that regulate proliferation of all cell type in organism and proposed special theory of aging as time -dependent decrease in lymphoid-regulation of somatic cell renovation ( Dontsov V.I., 1990, 1993 ). The thymus-dependent hypophys-induced degradation may be reversed, with restoration of growth, reproduction and some other symptoms of age by deferent methods, for example, embryo hypothalamic transplantation ( Ata-Muradova F.A. et al.1987; Matsumoto A.et al.,1984 ). --------------------------------------------------------------------------- p o - 11 - o o o a o r o o Ln M a o m o o e o t o o e o r o o s o 100- . * o o . * o . o * o . o + o* . + o + * +. + * + + . * + + . +* +F . +* + . I +* D ------------------------.---------------------------------------- Figure 1. 300 Time The general theoretical curve of time-depended renovation change and its depended age mortality in system, that contains renovated and regulatory non-renovated units. D - stimulator growth regulator cells, I - inhibitor growth regulator cells, F = D - I, M - age mortality M = Ln(1/F) ( For D=I=100, Kd=0.01, Ki=0.05, c=10, M=Ln(1/(F+c)*100) * 100 ) Reference. Ata-Muradova F.A., Dontsov V.I. Proc. Academy of Science of USSR, 1987.Vol.297,N.1.P.237-240 (Rus.). Dontsov V.I. The immunobiology of postnatal development. MOSCOW. Science. 1990. 152 p.( Rus.). Dontsov V.I. Age deficit of lymphocytes-regulator of somatic cells growth as probable central mechanism of aging in mammalians. In: "Aging and longevity". Ed.of Fund of longevity. Moscow,1993. N 1.P.18(Rus). Matsumoto A.et al.Proc.Japan Acap.,1984.Vol.60. Ser.B.N 4.P.73-76. --------------------------------------------------------------------------- - 12 - LYMPHOCYTES-REGULATORS OF CELL PROLIFERATION SHORTAGE AS POSSIBLE CENTRAL MECHANISM OF MAMMALIANS AGING. Dontsov V.I., MD. It is known that one of the central mechanism of mammalians aging is the age-dependent decrease of tissues proliferous potential that leads to decrease of tissues and organs self-renovation. The general decrease of age cell mitotic index affects all cell types and increase the cell share in G1 phase of cell cycle which is coincided to be the result of the well-known age cell G1/S block, the cause of which is unknown. Immunology considers the analogous G1/S block of age animals lymphocytes which proves to be the result of T-cells regulator populations: during age there is increase of T-suppressers share and decrease in T-helpers which results from hypothalamic-lymphocytes effects on the thymus in age. It has been shown that lymphocytes are capable of regulation a number of non-immune function in organism. Lymphocytes transfer the "regeneration information" to normal animals which increases the normal recipientts liver, kidney and other organs and tissues mitotic index in 10 or even 100-times; lymphocytes also take part in physiological self-renovation of proliferous cells containing tissues, in tissues hyperplastic processes, malignant cells growth, in organism growth and its restriction in age adults,in regulation of homeopathic cells differentiation and growth processes and other functions where cell proliferation and growth are the central physiological or pathogenic mechanism ( Babaeva, 1982; Prehn,1972; Rosenfeld et al.,1977; Wortis,1974 etc.). All these data severed the basis for our hypothesis that lymphocyte system of organisms has been primarily formed not only for immunity, but for regulation of all cell growth processes types which biologically are most impotent in all types of multicelular organisms. --------------------------------------------------------------------------- - 13 - In fact, the decrease of this lymphocytes function may be the central mechanism of aging, especially for proliferous cells containing tissues. The author has elaborated the theory of special lymphoid system in multicellular organisms regulating all types of cell proliferation and growth. Its elements are cell-proliferation-regulator lymphocytes of stimulator or inhibitor types ( CPL+ and CPL- ). The mathematical model have been created and CPL-dependent age-theory has been worked out ( Dontsov,1990,1993 ). The theory has the following postulates: 1) The main mechanism of tissue and whole organism age process is decreasing of its cell self-renovation. 2) It is the result of disballance in CPL-system of organism. 3) There is decrease of CPL/+/ share in age mammalians accompanied by the general decrease of CPL. 4) It brings to G1/S block both lymphocytes-effectors of immunity and proliferated somatic cells of all tissue types. 5) As a result, there is decrease in tissue renovation and increase in life time (duration) of individual low proliferated cells which enhances the share of low proliferated cells in tissues. 6) As tissue renovation mechanisms do not stop but only decrease there are always young cells present in age tissues as well as compensatory hyperplastic processes etc. 7) The disballance of CPL-system is the result of continued effects of the special central mechanism regulating the restriction of organism growth in the period when growth is stopped. The morphological substrate of this mechanism is hypothalamic growth regulator centers ( Ata-Muradova et al.,1987 ). --------------------------------------------------------------------------- - 14 - This theory being not contradictory but going along the same lines with the basis theories of age, it show the principal mechanism of age realization for self-regenerated tissues in connection with fundamental for all mammalians process - growth and its restriction. The effects on non-proliferated cell-types may also be described. References. Ata-Muradova F.A., Dontsov V.I. Proc. Academy of Science of USSR, 1987.Vol.297,N.1.P.237-240 ( Rus.). Babaeva A,G.,Nesterenko V.G.,Judina N.V.//Bulletin of experimental biology and medicine.1982.N.6.P.98 (Rus). Dontsov V.I. The immunobiology of postnatal development. Moscow. Science. 1990. 152 p.( Rus.). Dontsov V.I. Age deficit of lymphocytes-regulator of somatic cells growth as probable central mechanism of aging in mammalians// In: " Aging and longevity". Edition of Fund of longevity. Moscow. 1993.P.18(Rus.). Prehn R.T.//Science.1972.Vol.176.P.170-171. Rosenfeld R.,Thorsson A.V.,Hintz R.J. Clin.Endocrinol.and Methabol. 1977.Vol.48.P.456-461. Wortis H.//Contemp.Top.Immunobiol.,1974.Vol.3,P.243. PHYSICO-CHEMICAL AND BIOLOGICAL BASIS OF WEAK INTENSITY FACTORS EFFECTS. Podkolzin A.A.,MD, Dontsov V.I.,MD, Makaz V.G.,MD Physico-chemical and biological basis of high response of organisms to weak intensity factors ( low electric and magnetic fields, low currents, low doses of chemicals etc.) effects has been analyzed. The next specific mechanisms of this type effects are proposed: effects on different types of biomolecules oscillation, resonance of different cells structures, energy transformation from one type to another, effects on calcium ions activity etc. It has been shown the formation of the self-organization and hierarchic self-controlling processes in organism. The resonance mechanism may be the basis mechanism for weak intensity factor effects, especially for physical ones. The safety and high effective methods for treatment may be elaborated on the basis of weak intensity factor effects. --------------------------------------------------------------------------- - 15 - THE RESONANCE EFFECTS OF WEAK AC/DC MAGNETIC FIELD ON IMMUNNITY IN MICE. Podkolzin A.A.,MD, Dontsov V.I.,MD, Poponin V.P.,Ph.D. Central Scientific Research Laboratory of Moscow Medical Stomatological Institute, Lebedev Institute of Physics Russian Academy of Science. In present contribution activated by antigen immune cells of mice was used as test system in order to verify concept, that weak DC/AC magnetic field tuned on calcium resonance may influence on calmodulin dependent signal trunsduction pathways in cells. It has been shown previously [1], that for this mechanism to be effective it is necessary that calcium bound within protein be in nonequilibrium state. It is naturally to make assumption that nonequilibrium state of bound calcium is realized in activated cells. Plaque forming cells (PFC) from mice spleen were prepared on the 4th day after immunization. The erythrocytes of rats were used as antigens. Measurement of the antibody rate productivity was made by standard Canningham A.[2]. It was simple procedure of counting the number of plaques in the sample (special chambers). In the case then horizontal component of Geomagnetic field was compensated sharp resonance increase of antibody production activity was observed. Resonance was observed in the region of 15 to 60 Hz the resonance frequency depend on the value of vertical component of DC magnetic field. The width of resonance was 0.3 Hz and quality was in the range from 3 to 10. This results are interpreted in the framework of calcium octahedron complex concepts [1]. References Poponin V.P. Possible general primary mechanism for low power nonionizing radiation bioeffects. Transactions of the First Congress of The European Bioelectromagnetics Association, January 23-25, 1992, Brussels, Belgium, p.6. Canningham A.J. A method of increased sensitivity for detecting single antibody-forming cells// Nature.1965.Vol.207.P.1106-1107. --------------------------------------------------------------------------- - 16 - THE CLOSE-RESONANCE STIMULATION OF IMMUNITY IN MICE WITH WEAK PULSE CURRENT. Dontsov V.I.,M.D., Podkolzin A.A., MD The special feature of weak pulse current effects on immune antibody formation to rat erythrocytes has been investigated. Plaque forming cells (PFC) from mice spleen were registered on the 4-th day after immunization. The erythrocytes of rats were used as antigens. Measurement of the antibody rate productivity was made by standard Canningham A. method [1]. It was simple and precise procedure of counting the number of activated specific antibody-producing immune cells in the parallel triplicate sample in special chambers. It was fount the 2-10 time Immunomodulation of PFC-generation in mice spleen 4 days after immunization on 5-10 minutes weak pulse current effects during 1 hour after immunization for immunostimulation and 4 hour after immunization for immunosupression. The parameters of signal was: 543 +1 kHz frequency and triangular or quadratic signal form, that is typical for resonance mechanism effect of different stimulus. This results are interpreted in the framework of calcium octahedron complex concepts as possible general primary mechanism for low power nonionizing radiation bioeffects and in general weak intensity factor effects [2]. The resonance mechanism may be the basis mechanism for weak intensity factor effects, especially for physical ones. The safety and high effective methods for treatment may be elaborated on the basis of weak intensity factor effects. References Canningham A.J. Nature.1965.Vol.207.P.1106-1107. Poponin V.P. Transactions of the First Congress of The European Bioelectromagnetics Association, January 23-25, 1992, Brussels, Belgium, p.6. --------------------------------------------------------------------------- - 17 - NEW METHOD OF FUNCTIONAL AND BIOENERGETIC DIAGNOSIS,TREATMENT AND BIOSTIMULATION BY ORIGINAL ELECTROACUPUNCTURE WITHOUT EXTERNAL CURRENTS. Makaz V.G., MD Medical institute, Viniza, Ukraine. The method is works out and devices for electroacupuncture without external current are being produced. The principle distinction of it in contrast to all methods of electroacupuncture is in that that not the outside imposing of electric rhythms in used, but the stimulation of self activity of acupuncture points that allows to use minimum currents and conduct minute side effects. The unique results are ached while treating burns of large surface, quick anti-burn complications ( intestinal paresis etc. ), treatment of pneumonia by non-injective method, acceleration of different types reabilitaion processes etc. The special application for reactivating physiological state of tissues, organs and whole organism during age by this methods have shown in Institute of gerontology ( Kiev ) the unique results. The frequency-amplitude analyses of signals from acupuncture points are worked out that allows to receive new information about the state of acupuncture points, internal organs, especially in age processes. DEVICE AND PATENTED METHOD OF TUMOR DIAGNOSIS BY SPECTROFLUORESCENCE. Makaz V.G.,MD Medical institute, Viniza, Ukraine. On the basis of original self theoretical and experimental researches about the lymphoid control of different cells types, and especially tumors cell, growth the new theory of lymphoid mechanisms of cancer growth has been elaborated and new methods of its growth control have been shown. The new method of tumor risk diagnosis by the use of biophysical resonance-interference method ( that make it possible to accumulate specific cancer protein signals of small intensity against the background of considerable noise ) research of cancer patients serum fluorescence spectra was also elaborated, tested and patented. Common specific, independent of the tumor nature changes in fluorescence spectra were fount in double bland test on 200 different cancer patients and 200 controls with trustworthiness over 96% . --------------------------------------------------------------------------- - 18 - NEW OPPORTUNITIES OF WEAK BIOELECTROCURRENTS AND NON-IONIZING RADIATION IN DIAGNOSIS, TREATMENTS AND AGE BIOSTIMULATION. Dontsov V.I., MD We carry out fundamental theoretical experimental and clinical works on studying mechanisms of medical effect of weak currents and non-ionizing radiation, including the level of natural background. At first calmodulin- and calcium- dependent mechanisms of realization of such effects was shown. We fount out the narrow resonance stripes for biological effects and for the diagnosis aims by registration biocurrents, studying the influence of magnetic and electric fields on cells in isolated cells and whole organism. Immunostimulating, adaptogenic regimes are found out by using weak, principally harmful currents and physical fields. We designed devices ( apparatus BEST-1 ) for immunostimulation and treatment, for example influence, on our theoretical basis. NEW PROPERTIES FOR EFFECTS ON FREE-RADICAL MECHANISMS OF AGING BY ELECTROCHEMICAL ACTIVATED SYSTEMS. Podkolzin A.A., MD According to the modern notions, oxidizing-reduction homeostasis is central in stability of organism from intoxication and radial affection. The free radical-mechanism theory is also central modern theory of aging. Anti-age stimulation mechanisms needs in principally harmful agents that may be used for long time. All types of modern anti-oxidants remedies, unfortunately, are very toxic and its life-prolongation effects could not be used in humans for a long time. We investigated the EAS methods for preparation principally harmful agents form the water or weak solvent that may be used even in 1-2 L per day during many years. Apparatus and regimes are elaborated and patented. The method was tested for burns treating, immunostimulation and bioenergostimulation. The possibilities for correction of energetic state of age organisms is discussed, as the using EAS as radioprotection etc. --------------------------------------------------------------------------- - 19 - FOUNDATION of LIFE PROLONGATION PRESENT ORIGINAL SCIENTIFIC REPORTS: 1.THE LYMPHOID MECHANISMS OF DIFFERENT CELL GROWTH PROCESSES REGULATION IN MAMMALIANS:NEW IMMUNE THEORY of AGING. On the basis of monography: Vitaly I. Dontsov "Immunobiology of the postnatal development". Academic Press"Science".Moscow,1990. Monography is dedicated to new lymphocytes function: its possibility to regulate growth of different cell type. Theoretical mathematical models, special bibliography and original experimental studies illustrate as some, special, type of T-lymphocytes regulate regeneration, normal and tumor growth, immunity,self physiological regeneration of different tissue and specially as reduction of this lymphocyte function result in age - reduction of cell renovation (physiological tissue self regeneration - the main mechanism of age). It is described the lymphocytes phenotype, process dynamic and molecular mechanisms of this lymphocyte type activation and mechanisms of its effects on tissues. The elaboration of the special computer models of this lymphocytes function make it possible the concreteness for different physiology and pathology statements, particularly the New Lymphoid Theory of Age model has been elaborated. 2.FUNDAMENTAL MECHANISMS AND AGING TYPES. Original theoretic and experimental reports about the computer models of sell-renovation processes in mammalians, that may it possible to obtain the whole graphic of age mortality and to speculate about probable physiological sense of it. Theoretical presentation of 4 principal general types of aging and special role of the critical for mammalians aging mechanismreduction of self tissues renovation; special models of its regulation mechanisms in mammalians and humans especially. The principal new lymphoid theory of aging, based on the new lymphocytes function - its possibility to regulate growth of different cell type. Theoretical mathematical models, special bibliography and original experimental studies illustrate the mathematical mo dels of self physiological regeneration of different tissue and specially as reduction of this lymphocyte function result in age - reduction of cell renovation. --------------------------------------------------------------------------- - 20 - 3.NEW LYMPHOID CONTROL MECHANISMS OF TUMORS GROWTH AND NEW DIVICE METHOD OF TUMOR AND TUMOR RISK DIAGNOSIS. On the basis of original self theoretical and experimental researches about the lymphoid control of different cells types, and especially tumors cell, growth the new theory of lymphoid mechanisms of cancer growth has been elaborated and new methods of its growth control have been shown. The new method of tumor risk diagnosis by the use of biophysical resonance-interference method ( that make it possible to accumulate specific cancer protein signals of small intensity against the background of considerable noise ) research of cancer patients serum fluorescence spectra was also elaborated, tested and patented. Common specific, independent of the tumor nature changes in fluorescence spectra were fount in double bland test on 200 different cancer patients and 200 controls with trustworthiness over 96% . 4.NEW OPPORTUNITIES OF WEAK BIOELECTROCURRENTS AND NON-IONIZING RADIATION IN DIAGNOSIS,TREATMENTS,BIOSTIMULATION. We carry out fundamental theoretical experimental and clinical works on studying mechanisms of medical effect of weak currents and non-ionizing radiation, including the level of natural background. At first calmodulin- and calcium- dependent mechanisms of realization of such effects was shown. We fount out the narrow resonance stripes for biological effects and for the diagnosis aims by registration biocurrents, studying the influence of magnetic and electric fields on cells in isolated cells and whole organism. Immunostimulating, adaptogenic regimes are fount out by using weak, principally harmful currents and physical fields. We designed devices ( apparatus BEST-1 ) for im munostimulation and treatment, for example influence, on our theoretical basis. The unique results are ached while treating burns of large surface, quick anti-burn complications ( intestinal paresis etc. ), treatment of pneumonia by non-injective method, acceleration of different types reabilitaion processes etc. The special application for reactivating physiological state of tissues, organs and whole organism during age by this methods have shown in Institute of gerontology ( Kiev ) the unique results. --------------------------------------------------------------------------- - 21 - 5.NEW POSSIBILITIES FOR CORRECTION OF ENERGETIC STATE OF ORGANISM BY ELECTROACTIVATED SYSTEMS. According to the modern notions, oxidizing-reduction homeostasis is central in stability of organism from intoxication and radial affection. The free radical-mechanism theory is also central modern theory of aging. Anti-age stimulation mechanisms needs in principally harmful agents that may be used for long time. All types of modern anti-oxidants remedies, unfortunately, are very toxic and its life-prolongation effects could not be used in humans for a long time. We investigated the EAS methods for preparation principally harmful agents form the water or weak solvent that may be used even in 1-2 L per day during many years. Apparatus and regimes are elaborated and patented. The method was tested for burns treating, immunostimulation and bioenergostimulation. The possibilities for correction of energetic state of age organisms is discussed, as the using EAS as radioprotection etc. FOUNDATION of LIFE PROLONGATION PRESENT ORIGINAL SCIENTIFIC PROJECTS: 1.THE EXPERIMENTAL RESEARCH OF RESTORATION GROWTH POTENTIAL OF DIFFERENT TISSUES IN AGE BY IMMUNOMODULATORS. MAIN IDEA: To show the possibility and regimes of immunomodulators application for restoration of different tissues growth potential, based on original experiments and theory of special type lymphocytes function - regulation of non-immune cells growth. --------------------------------------------------------------------------- - 22 - 2.THE EXPERIMENTAL RESEARCH OF DEPRESSION GROWTH POTENTIAL OF DIFFERENT TUMOR TISSUES BY IMMUNOMODULATORS. MAIN IDEA: To show the possibility and regimes of immunomodulators application for depression different tumor tissues growth potential, based on original experiments and theory of special type lymphocytes function - regulation of non-immune cells growth. 3.THE EXPERIMENTAL RESTORATION OF THE ORGANISM-DEVELOPMENT PROGRAM BY EMBRIO HYPOTHALAMIC CENTERS TRANSPLANTATION. MAIN IDEA: To show the possibility of life-prolongation and age-linked function restoration by methods of "Tissues engineering": transplantation to the old animal brain embryonic hypothalamic centers. First experiments has shown the effectiveness of this method for restoration of growth rate, stop age body and organs mass loss, restoration immune function, electroencephalografy- and test-memory function. 4.NEW THEORETICAL MODEL OF LYMPHOID REGULATION OF CELL GROWTH PROCESS IN ORGANISM AND NEW THEORY OF AGE. MAIN IDEA: The elaboration of the special computer models of new lymphocytes function and concreteness of the processes of different cell growth regulation by special types of lymphocytes for different physiology and pathology statements, particularly the New Lymphoid Theory of Age model may been elaborated. The commercial products for research, education and advertisement may be elaborated. On the basis of monography: Vitaly I.Dontsov"Immunobiology of the postnatal development". Academic Press"Science".Moscow,1990. Monography is dedicated to new lymphocytes function - its possibility to regulate growth of different cell type.Theoretical mathematical models, special bibliography and original experimental studies should illustrate as some, special, type of T-lymphocytes regulate regeneration, normal and tumor growth, immunity, self physiological regeneration of different tissue and specially as reduction of this lymphocyte function result in age - reduction of cell renovation (physiological tissue self regeneration - the main mechanism of age). --------------------------------------------------------------------------- - 23 - THE CLINICAL RESEARCHES A.THE FUNDAMENTAL RESEARCHES AND CLINICAL APPLICATION OF ORIGINAL ELECTROACUPUNCTURE WITHOUT EXTERNAL CURRENTS. MAIN IDEA: To show that new method of electroacupuncture do not only activate different function, depressed in age, but also effect on Biological Age indexes. The principle distinction of new electroacupuncture stimulation method in contrast to all methods of electroacupuncture is in that that not the outside imposing of electric rhythms in used, but the stimulation of self activity of acupuncture points,that allows to use minimum currents and conduct minute side effects. The first special application for reactivating physiological state of tissues, organs and whole organism during age by this methods have shown in Institute of gerontology ( Kiev ) the unique results. B.NEW OPPORTUNITIES OF WEAK BIOELECTROCURRENTS AND NON-IONIZING RADIATION IN AGE BIOSTIMULATION. MAIN IDEA:To show that new method of bioelectroimmunostimulation do not only activate different functions, depressed in age, but also effect on Biological Age indexes. We carry out fundamental theoretical experimental and clinical works on studying mechanisms of medical effect of weak currents and non-ionizing radiation, including the level of natural background. Immunostimulating, adaptogenic regimes are fount out by using weak, principally harmful currents and physical fields. We designed devices ( apparatus BEST-1 ) for immunostimulation and treatment, for example influen --------------------------------------------------------------------------- - 24 - C.NEW POSSIBILITIES FOR CORRECTION OF ENERGETIC STATE OF ORGANISM BY ELECTROACTIVATED SYSTEMS ( EAS ). MAIN IDEA: To show that new method activate different functions, depressed in age, and effect on Biological Age indexes. The free radical mechanism theory is one of the central modern theory of aging; oxidizing-reduction homoeostasis,is believed, to be central in stability of organism from intoxication and radial affection. All types of modern anti-oxidants remedies, unfortunately, are very toxic and its life-prolongation effects could not be used in humans for a long time. We investigated the EAS methods for preparation principally harmful agents from the water or weak solvent that may be used even in 1-2 L per day. NEW COMPLEX SCIENTIFIC-RESEARCH PROGRAMME NEW BIOLOGICAL and PHYSICAL METHODS IN DIAGNOSTICS and TREATMENT of TUMOURS Researches workes of Central research laboratory of Moscow medical stomatologocal institute of Ministry of Public Health, Institute for Physics and Institute for Chemical Physics of Russian Academy of Sciences, Institute for Immunology of Academy of Medical Sciences of Russia, Medical Institute of Vinniza took part in work. As a result of their work was shown: - in the fields of fundamental researches the principally new mechanism of immune control of the process of cell growth of non-immune types of tissues was discovered; the ability of definite types of T-lymphocytes to controll directly cell growth in the course of regeneration induced growth of many tissues and tumour growth was proved;the possibility to control of --------------------------------------------------------------------------- - 25 - growth of transplanted tumours was achieved; - the number of qualities of such lymphocytes and methods of influencing them by the biologically active agents and physical factors was studied; the patent on the method of defining factors secreted by such cells was received ( "Immunobiology of postnatal development":Moscow, Science ( Rus.); Experimental oncology, 1989,N.5); - the theory of "factors of low intensivity" was formulated. It lets use princilially unharmful and highly effective methods of effecting by weak physical fields, galvanic currents and small doses of biologicaly active, natural ( in the first place ) means for the arms of diagnostics, treatment and prophylaxis ( "Factors of low intensivity in bioactivation and immunocorrection",Moscow,1995(Rus.); Achievments of modern biology",1994, vol.114, p.160 ( Rus.); etc. - the methods of bioimmunoactivation of apparatus and biologically active agents were worked out ( "Basis of bioenergotherapy ",Vinniza, 1991; Achievements of modern biology,1994, vol.114, p160 ); - the possibilites of use of some physical factors for diagnostics of tumour process were researched - fluorescence of blood proteins, apearing along with tumour process, and the changes in the structure of biomagnetic field and biopotentials of body surface of organism as well. THE CONTENTS OF WORKS. 1. The working out of experimantal approaches to growth regulatiom and differentiation of tumours on the basis of influencing the immune systems of organism: the newly discovered types of lymphocytes. Must be studied; - enphasized and characterized in detail types of such lymphocutes and factors secreted by them; - the sensitiveness of such cells to various regulatory effectc of immunocorretive means in the first place and physical factors; - schemes for effecting lymphocytes of such type for effecting lymphocytes of such type for control of tumour growth have been worked out; --------------------------------------------------------------------------- - 26 - 2. The working out of methods of growth control of tumour cells by biologically active natural factors. Must be studied: - possibilities of control of tumour cells growth and possibilities of induction of their differentiation by means of isolated from animal blod serum growth-correcting lypophylic proteins ( im cooperation with Centre of Maternity and Childhood ) and also the possibility of use of such proteins in a man with prophylactic and treatment aim, and as radioprotectors and anti-viral means, processing immuno-corrective activity; - the possibility to correct a tumour growth processes by new medicines, made on bases of natural components; - the possibility of correction of tumour process with application of weak modulated magnetic field, for which the possibility of influencing the processes of tumour growth and differentiation is shown by our invastigations; 3. The working out of new methods of diagnostics of tumours processes and wide use for screening among the "risc" group of patients. Must be: - methods of fluorscence diagnostics of tumour-diagnostic blood proteins aproved; - methods of registration of biomagnetic field changes and biopotentials with the aim of diagnostics; - in the cooperation with the Institute of Traditional treatment methods ( Ministru of Health of Russin Federation ) and taking into consideration out the experiments im this field to evaluate the possibilities of use of method of bioenergoinformational tumour diagnostics on the base of phenomenon of "supersensitiveness" of some people to fields of low intensity. ------------------------------------------------------------------- This publication is prepared with assistence of FOUNDATION for LIFE PROLONGATION WE ARE NEED OF SCIENCE CONTACTS AND OF INTERNATIONAL FOUNDATIONS ASSISTENCE E.MAIL: agerus95@glas.apc.org ( in GlasNet ) From owner-ageing@net.bio.net Fri Jul 07 23:00:00 1995 Path: biosci!agate!overload.lbl.gov!emf.emf.net!gatech!rutgers!oitnews.harvard.edu!purdue!mozo.cc.purdue.edu!not-for-mail From: barani@mace.cc.purdue.edu (Barani) Newsgroups: bionet.molbio.ageing Subject: ageing or aging?! (on the lighter side) Date: 8 Jul 1995 13:11:33 -0500 Organization: Purdue University Lines: 9 Message-ID: <3tmhol$1cq@mace.cc.purdue.edu> NNTP-Posting-Host: mace.cc.purdue.edu 'Aging' might be better than 'ageing' but surely 'dyeing' is better than 'dying'! :-) From owner-ageing@net.bio.net Sun Jul 09 23:00:00 1995 Path: biosci!rutgers!gatech!news.uoregon.edu!vixen.cso.uiuc.edu!uchinews!news.luc.edu!jerikse From: jerikse@news.luc.edu (Jason L. Eriksen) Newsgroups: bionet.molbio.ageing Subject: Re: Free Radicals in Cell Nuclei? Date: 10 Jul 1995 20:56:37 GMT Organization: Loyola University Chicago Lines: 22 Message-ID: <3ts465$oij@apollo.it.luc.edu> References: <3tli5v$utc@www.uno.edu> NNTP-Posting-Host: bsd.meddean.luc.edu X-Newsreader: TIN [version 1.2 PL2] kgpl@uno.edu wrote: : Someone has suggested to me that a lot of age-related damage may : be the result of accidental miscopying of DNA due to the presence : of free-radicals in cell nuclei messing up the copying process. : Is this possible? What kinds of free-radicals are generated within, : or can get into, the nucleus of a cell? Is there any reason to : suspect that this sort of damage is more likely to occur during : the process of cell division? Oxygen-derived radicals, such as radicals and peroxides, seem to be byproducts of a lot of cellular processes. Cellular respiration, especially, seems to generate huge amounts of free radicals in cells, most of which are mopped up by superoxide dismutase and related free radical compensatory pathways. Free radicals may cause cross-linkages of cell proteins to occur, leading to lots of junk to accumulate in the cell. There is also a possibility that some sort of DNA damage can occur via normal respiratory processes, although given the efficiency of repair, permanent damage appears to be an infrequent occurance (thank goodness!). Regards, Jason Eriksen From owner-ageing@net.bio.net Sun Jul 09 23:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!sjuvm!yprlbio Nntp-Posting-Host: 149.68.2.20 Date: Mon, 10 Jul 1995 07:55:47 -0400 From: "LOCKSHIN, RICHARD A" Newsgroups: bionet.molbio.ageing Subject: RE: cell-death meeting Message-ID: <10JUL95.08563359.0022@sjumusic.stjohns.edu> References: Sender: usenet@sjumusic.stjohns.edu Organization: St. John's University Lines: 31 you just missed a gordon conference on cell death. There are a few commercially-sponsored meetings that crop up now and then, especially in the west, such as the one currently advertized that will be in Pittsburgh (look at cellbiol if it isn't here). I doubt that they will be as informative. Watch in the areas of immunology, including AIDS groups, cancer, and neurology. Also, since you have a Canadian address, there is a large group at the NRC Ottawa that may sponsor a meeting. Richard A. Lockshin/Dept. Biol. Sci. St. John's U. 8000 Utopia Pkwy Jamaica NY 11439 USA/Phone 718: 990-1854/ Fax 718: 380-8543 In article shah@RESUNIX.RI.SICKKIDS.ON.CA writes: >Hi, >I am a PhD graduate student in yeast genetics and very close to graduation. >I have decided that I would like to pursue the field of programmed cell >death for my Post Doc and hopefully future career. I would love to be able >to go to a cell-death meeting this year to familiarize myself with the >field and get to know the people in the field. I know that there is a Cold >Spring Harbour meeting coming in September, but I am told that it would be >difficult to attend the meeting since I don't belong to a cell-death lab. >Do you have any advice for me as to how I can attend this meeting, whether >there are any other meeting that I might go to that is not as restricted >and equally informative. I thank you in advance for your help and >suggestions. > >Sherry >shah@resunix.ri.sickkids.on.ca > > >. >. From owner-ageing@net.bio.net Sun Jul 09 23:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!noc.netcom.net!netcomsv!uu3news.netcom.com!netcomsv!uucp3.netcom.com!foodcom!FoodCom From: FoodCom@foodcom.com (FoodCom) Reply-To: FoodCom@foodcom.com Newsgroups: bionet.molbio.ageing Distribution: world Subject: FoodCom News [Annoucement] Date: 10 Jul 1995 06:35:04 GMT Message-ID: <2633433086.84048463@foodcom.com> Organization: FoodCom Lines: 82 INTRODUCING "FOODCOM NEWS*" Announcing the first and only "interactive" electronic on-line newspaper for professionals in the food and beverage industry - "FoodCom News." Now any professional working in or servicing the food and beverage industry world-wide may contribute news, information and articles to this on-line newspaper -- at no cost -- simply by sending email via the Internet to foodcomnews@foodcom.com. Members of the FoodCom* On-line Service may also submit articles via FoodCom email. This unique new service permits the world-wide members of the FoodCom On-line Service to read an article and then reply directly to the author of the article via email -- no matter where in the Internet world the article originated. This makes it easy for the reader to request more information, and convenient for the author of the article to develop new business relationships world-wide via electronic mail. FoodCom members can even use FoodCom's powerful search capabilities to "read" FoodCom News and create their own custom newspaper by automatically gathering those articles of specific interest. SUGGESTIONS FOR USING "FOODCOM NEWS" Use "FoodCom News" to publish news and information about yourself, your company or anything you believe is newsworthy to the food and beverage industry. Here are some ideas for how to use "FoodCom News." * Announce your membership at FoodCom and tell how you would like to use FoodCom to communicate and do business with the industry. * Build awareness of your Internet email addresses or World Wide Web site among professionals in the food and beverage industry. * Publish an article about food and beverage trends. * Make the food industry aware of an upcoming convention, seminar or event. * Introduce new products and services. * Report organizational changes. * Publish an article about your services and products. * Post messages about employment opportunities or seek career advancement. The possibilities are endless to how you can use this opportunity to keep FoodCom members well informed. TO SUBMIT AN ARTICLE VIA INTERNET EMAIL If you, or someone you know, would like to submit an article to "FoodCom News" via the Internet, simply send your article as an email message and address it to: foodcomnews@foodcom.com Hints & tips: 1) Write a short, yet clear topic description in the subject line of your email heading. Try to stay within 25 characters. 2) Check for spelling. 3) Ask for readers to reply via email or take some kind of action. 4) Be sure to include in your article any information about how to contact you or your company. Articles submitted to "FoodCom News" are first read by FoodCom System Operators and then approved for public viewing. This is done to screen-out any irrelevant electronic "junk mail" -- a necessary step as "FoodCom News" is open to any user of the Internet. Announcements and articles sent and approved will be published as submitted. In one to two business days you will receive an email confirmation from FoodCom that your article has been published in "FoodCom News." We look forward to your contributions to "FoodCom News" and hope you find it a valuable means of keeping the food and beverage industry informed. If you have any questions or comments, or would like more information about FoodCom, please contact us at: Email: info@foodcom.com WWW: http://www.foodcom.com/foodcom/ Ph: (415) 637-8319 Fax: (415) 637-7751 See you on-line, FoodCom ----------------------------------------------------------- This message was sent via FoodCom. info@foodcom.com Ph:(415) 637-8319 http://www.foodcom.com/foodcom/ From owner-ageing@net.bio.net Sun Jul 09 23:00:00 1995 Path: biosci!IUNHAW1.IUN.INDIANA.EDU!TSTABLER From: TSTABLER@IUNHAW1.IUN.INDIANA.EDU ("Tim Stabler") Newsgroups: bionet.molbio.ageing Subject: Questions Date: 10 Jul 1995 07:57:19 -0700 Organization: Indiana University Northwest Lines: 29 Sender: daemon@net.bio.net Distribution: world Message-ID: <6323BA2FB7@iunhaw1.iun.indiana.edu> NNTP-Posting-Host: net.bio.net I have been on this net for a couple weeks and, now that I have read some mail, woyld like to post two questions for the group. 1. Is there anyone else on the net that teaches a biology of aging course? I am teaching a class I developed for Indiana University called "Biological Aspects of Aging" and I really enjoy it. I was curious what others are using for texts (I use the book by DiGiovanna of Salibury State) and how you might cover various topics. Any comments would be welcome. 2. I was at a meeting about animal care and a fellow from Washington that works with a NIH search group or something (I lost references) said that Medline only covers about half of what is published. I do go out to decubitus ulcer meetings (although not that much recently due to the sponsoring company wanting to go in other directions) and talk on the aging of the skin and immune system. I also add in info on ulcers and burns in the older person----all related to skin aging. Wanting to keep my material up-to-date, my question is what is the "other half" and how do I access it? Thanks for the info. DR. Tim Stabler Department of Biology Indiana University Northwest Gary, Indiana 46408 219-980-6718 FAX:219-980-7125 From owner-ageing@net.bio.net Sun Jul 09 23:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!sjuvm!yprlbio Nntp-Posting-Host: 149.68.2.20 Date: Mon, 10 Jul 1995 07:58:05 -0400 From: "LOCKSHIN, RICHARD A" Newsgroups: bionet.molbio.ageing Subject: RE: cell-death meeting Message-ID: <10JUL95.08604941.0022@sjumusic.stjohns.edu> References: Sender: usenet@sjumusic.stjohns.edu Organization: St. John's University Lines: 27 Follow-up: If "sick-kids means Hospital for Sick Children, Toronto, watch also if U of Rochester has any symposia or, if you get to New York, we have an active cell death club that meets once per month. Richard A. Lockshin/Dept. Biol. Sci. St. John's U. 8000 Utopia Pkwy Jamaica NY 11439 USA/Phone 718: 990-1854/ Fax 718: 380-8543 In article shah@RESUNIX.RI.SICKKIDS.ON.CA writes: >Hi, >I am a PhD graduate student in yeast genetics and very close to graduation. >I have decided that I would like to pursue the field of programmed cell >death for my Post Doc and hopefully future career. I would love to be able >to go to a cell-death meeting this year to familiarize myself with the >field and get to know the people in the field. I know that there is a Cold >Spring Harbour meeting coming in September, but I am told that it would be >difficult to attend the meeting since I don't belong to a cell-death lab. >Do you have any advice for me as to how I can attend this meeting, whether >there are any other meeting that I might go to that is not as restricted >and equally informative. I thank you in advance for your help and >suggestions. > >Sherry >shah@resunix.ri.sickkids.on.ca > > >. >. From owner-ageing@net.bio.net Mon Jul 10 23:00:00 1995 Path: biosci!POSSUM.MURDOCH.EDU.AU!cummins From: cummins@POSSUM.MURDOCH.EDU.AU (Dr Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Re: Free Radicals in Cell Nuclei? Date: 10 Jul 1995 18:10:35 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 38 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net >kgpl@uno.edu wrote: >: Someone has suggested to me that a lot of age-related damage may >: be the result of accidental miscopying of DNA due to the presence >: of free-radicals in cell nuclei messing up the copying process. >: Is this possible? jerikse@apollo.it.luc.edu wrote >Oxygen-derived radicals, such as radicals and peroxides, seem to be byproducts >of a lot of cellular processes. Cellular respiration, especially, seems to >generate huge amounts of free radicals in cells, most of which are mopped up >by superoxide dismutase and related free radical compensatory pathways. Most if not all oxidative metabolism (the major generator of free radicals) is confined to mitochondria. Some think that sequestering this dangerous business away from the nucleus to these sacrificial "slave" organelles is essential to minimise the danger to the somatic genome. Lindahl, T. (1993). Instability and decay of the primary structure of DNA. Nature, Lond, 362, 709-725. Max, B. (1992). This and that: hair pigments, the hypoxic basis of life and the Virgilian journey of the spermatozoon. Trends Pharmacol Sci, 13, 272-276. Jim "Spermatology rules o~ o~ o~ o~" Cummins Associate Professor in Veterinary Anatomy Murdoch University, Western Australia 6150 Tel +61-9-360 2668, Fax +61-9-310 4144 E mail URL "An inordinate fondness for Beetles" (Haldane on God). From owner-ageing@net.bio.net Mon Jul 10 23:00:00 1995 Path: biosci!ilr.rc.ac.ru!gavrilov From: gavrilov@ilr.rc.ac.ru ("Leonid A.Gavrilov") Newsgroups: bionet.molbio.ageing Subject: Lectures on Gerontology and Longevity Research Date: 11 Jul 1995 09:51:46 -0700 Organization: A.N.Belozersky Institute Lines: 184 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Dear Colleagues, On August-September, 1995 Dr.Natalia S.Gavrilova, Ph.D. and myself will be travelling across the Europe (The Netherlands, Belgium, France, Great Britain, etc.) giving lectures and seminars based on our research work. The purpose of these seminars is to establish scientific collaboration and to collect funds for establishing the Institute for Longevity Research in Moscow (the first gerontological institute in the history of Russia !). Now we are forming the schedule of our visits and seminars and we would be happy to consider any invitations and suggestions in this direction. We already had very positive experience with our lectures in Germany, France, United Kingdom and USA. Our lectures are based on the recent progress in our research work and our book: THE BIOLOGY OF LIFE SPAN: A QUANTITATIVE APPROACH that received a lot of positive reviews in the leading scientific journals by the leading gerontologists (see attachment printed below). Sincerely yours, Dr.Leonid A.Gavrilov, Ph.D. Member of the Council of Russian Gerontological Society P.S.: Recommendations of our lectures based on our book are printed below. *************************************************************************** "HIGHLY RECOMMENDED FOR STIMULATING FRESH APPROACHES ... " - Professor Roy L.Walford, M.D., UCLA School of Medicine, USA. THE GERONTOLOGIST, 1991, vol.31, No.5, p.707. "CLEARLY, THIS IS A VERY INTERESTING, PROVOCATIVE AND THOUGHT-PROVOKING BOOK" - Dr. Ward Dean, M.D., The Center for Bio-Gerontology, Pencasola, Florida, USA. EXPERIMENTAL GERONTOLOGY, 1992, vol.27, No.2, pp.251-253. "THIS IS AN INTERESTING BOOK, FULL OF TABLES AND DATA AND POLEMICAL IN ITS APPROACH." - Professor William A.Pryor, Director of Biodynamic Institute, Louisiana State University, Baton Rouge, LA,USA. FREE RADICAL BIOLOGY & MEDICINE, 1992, vol.12, pp.331-332. "IT BRINGS TO BEAR A FRESH APPROACH WHOSE IDEAS ARE LOGICALLY PRESENTED AND DEVELOPED". - Dr. Brian Merry, Ph.D., Institute of Human Aging, University of Liverpool, United Kingdom. AGEING AND SOCIETY, 1991, vol.11, No.4, pp.509-510. "GOOD NEW BOOK ON AGEING". - Dr. Thomas B.L.Kirkwood, Ph.D. Head of the Laboratory of Mathematical Biology, National Institute for Medical Research, London, United Kingdom. NATURE, 1991, vol.352, 29 August, pp.767-768. "... SHOULD BE READ BY ANYONE SERIOUSLY INTERESTED IN AGEING. ... YOU WILL FIND THIS A SURPRISINGLY GOOD 'READ', AND A MUST FOR EVERY LIBRARY". - Dr. D.Sebastian Fairweather, Physician, Department of Geriatric Medicine, Oxford, United Kingdom. AGE AND AGEING, 1992, vol.21, No.5, pp.386-387. "THE BOOK FEATURES QUITE A BIT OF DEMOGRAPHIC THEORY AND ANALYSIS. ... IT IS REFRESHING" - Professor Michael R.Rose, University of California, Irvine, USA. ANNALS OF HUMAN BIOLOGY, 1992, vol.19, No.3, pp.320-321. "THE GAVRILOVS HAVE MADE A VALUABLE CONTRIBUTION TO THE STUDY OF LIFE SPAN, AND ANY FUTURE WORK ON THE SUBJECT WILL HAVE TO TAKE ACCOUNT OF THE RICH CONTENTS OF THIS BOOK". - Dr. Vaino Kannisto, Former United Nations Adviser on Demography POPULATION STUDIES, 1992, vol.46, No.2, pp. 366-367. "EIN AKTUELLES BUCH, DAS SICHERLICH DIE INTERNATIONALE DISKUSSION DES PROBLEMS BEFORDERN KANN." - Prof. Dr. Ingeborg Falck, Berlin, Germany. ZEITSCHRIFT FUR GERONTOLOGIE, 1991, Band 25, Heft 1, S.56. "THE BOOK IS WELL WRITTEN, EASY TO READ, AND SHOULD BE OF INTEREST TO A WIDE SPECTRUM OF READERS INCLUDING PHYSICIANS, BIOLOGISTS, BIOCHEMISTS, GERONTOLOGISTS..." - Prof. Robert W.Gracy, University of North Texas, USA. EDUCATIONAL GERONTOLOGY, 1993, vol.19, No.1, pp.92-93. "... THIS BOOK IS A HIGHLY VALUABLE CONTRIBUTION TO THE DISCIPLINE. ...THIS BOOK SHOULD MAKE SCIENTISTS TAKE NOTICE OF RESEARCH ON AGING AND LONGEVITY ... IN THE FORMER SOVIET UNION" - Dr. S.Jay Olshansky, Ph.D., University of Chicago, USA POPULATION AND DEVELOPMENT REVIEW, 1992, vol.18, No.3, pp.555-558. "... MANY WILL FIND AN EXCURSION INTO IT STIMULATING". - Dr. Emily Grundy, Lecturer in Gerontology, Age Concern Institute of Gerontology, King's College, London, UK. BRITISH MEDICAL JOURNAL, 1992, vol.305, No.6850, p.431. "GAVRILOV MAKES THE BEST ATTEMPT I KNOW OF TO DISTINGUISH HOW LONG PEOPLE COULD LIVE FROM HOW LONG THEY ACTUALLY LIVE - ONE OF THE MORE DIFFICULT TASKS FOR BOTH BIOLOGY AND STATISTICS... GAVRILOV'S SCHOLARSHIP IS IMPRESSIVE". - Professor Nathan Keyfitz, International Institute for Applied Systems Analysis, Laxenburg, Austria. MATHEMATICAL POPULATION STUDIES, 1991, vol.3, No.2, p.161. "LEONID GAVRILOV IS A TOP-FLIGHT STATISTICAL POPULATION BIOLOGIST... THE AREA IS IMPORTANT WELL BEYOND THE CONFINES OF BIOLOGICAL GERONTOLOGY AND EXTENDS INTO POLITICS AND SOCIAL PLANNING. GAVRILOV IS VERY GOOD ON JUST THIS SORT OF THING. HE HAS A FRESH APPROACH, NEW IDEAS, A GREAT DEAL OF DATA NOT READILY AVAILABLE ELSEWHERE." - Roy. L. Walford, Professor of Pathology, UCLA School of Medicine, USA. MATHEMATICAL POPULATION STUDIES, 1991, vol.3, No.2, p.161. "THIS BOOK IS DIRECTED TOWARD RESEARCHERS INTERESTED IN STATISTICAL PATTERNS AND MATHEMATICAL MODELS OF HUMAN LIFE SPAN. FOR STUDENTS WITHIN THIS DEFINED AREA OF RESEARCH, THIS TEXT OFFERS A GOOD HISTORICAL PERSPECTIVE, INSIGHT INTO THE RUSSIAN LITERATURE, AND INSIGHT INTO THE QUANTITATIVE ANALYSIS OF LIFE SPAN" - Dr. Deborah A.Roach, Department of Zoology, Duke University, Durham, USA. ECOLOGY, 1992, vol.73, No.1, pp.379-381. "THIS BOOK IS IN ESSENCE A BIOSTATISTICAL ANALYSIS OF THE PROBLEMS OF LIFESPAN, HUMAN AND ANIMAL. ... THE LITERATURE IN MANY LANGUAGES HAD CLEARLY BEEN WELL COVERED, AND MUCH HAS BEEN MADE OF NATIONAL AND OTHER MORTALITY STATISTICS IN THIS CENTURY. ... A USEFUL SOURCE BOOK." - Dr. F.I.Caird, D.M., F.R.C.P., Professor of Geriatric Medicine, Southern General Hospital, Glasgow, UK. J. OF CLINICAL AND EXPERIMENTAL GERONTOLOGY, 1992, vol.14, No. 3 & 4, p.309. "THIS INTELLIGENT AND THOUGHT PROVOKING BOOK SHOULD BE READ WIDELY" - Dr. Suresh I.S.Rattan, Ph.D., Laboratory of Cellular Ageing, Aarhus University, Denmark. INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 1993, vol.31, p.499-500. "... THE READER WILL BENEFIT ENORMOUSLY FROM THE BROADENING OF PERSPECTIVE AS A RESULT OF EXPOSURE TO THE GAVRILOVS' THEORIES ON THE BIOLOGY OF LIFE SPAN" - Dr. M. Michael Akiyama, University of Michigan, Dearborn, USA. HUMAN BIOLOGY, 1992, vol.64, No.4, pp.630-632. "THIS IS A PROVOCATIVE AND REFRESHING BOOK" - Dr.Alan R.Hipkiss, Age Concern Institute of Gerontology, King's College London, UK. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 1992, vol.7,No.8,p.614. "THIS BOOK SHOULD BE READ BY ALL MEMBERS OF THE PROFESSION INTERESTED IN MORTALITY - WHICH SHOULD BE ALL MEMBERS OF THE PROFESSION" - Dr. H.A.R.Barnett, Institute of Actuaries, UK. J.OF THE INSTITUTE OF ACTUARIES, 1992, vol.119, Part II, pp.379-381. "TO SUM UP, THE BOOK IS SUBSTANTIAL, INTERESTING AND BRINGS FRESH AIR. WE CAN CONFIDENTLY COMMEND ITS STUDY TO ALL SCIENTISTS ... " - Dr. Janos Izsak, Department of Zoology, Berzsenyi Teachers' College, Szombathely, Hungary. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1992, vol.15, No.2,pp.192-194. "A GENERAL THEORY OF LIFESPAN IS THUS CREATED." - - Dr. Norman Vetter, University Hospital of Wales, Cardiff, UK. J.OF EPIDEMIOLOGY & COMMUNITY HEALTH, 1992, vol.46, No.6, p.630. "I FOUND IT TO BE HIGHLY REWARDING READING." - Dr. Edward J.Masoro, University of Texas Health Science Center. QUARTERLY REVIEW OF BIOLOGY, 1993, vol.68, p.92. "THIS ... IS AN EXCELLENT BOOK. ... NOBODY INTERESTED IN AGING SHOULD FAIL TO READ". - Dr. C.S.Downes, Department of Zoology, University of Cambridge, UK. BIOESSAYS, 1993, vol.15, No.5, pp.359-362. "...PROVOCATIVE AND ENTERTAINING READING AND CAN BE RECOMMENDED TO ANYONE WITH AN INTEREST IN BIOLOGICAL AGING." - Dr. Douglas E.Crews, Department of Anthropology, Ohio State University, USA JOURNAL OF CROSS-CULTURAL GERONTOLOGY, 1993, vol.8, No.3, pp.281-290. "IT DESERVES TO BE READ WIDELY. SCIENTISTS AND PHYSICIANS WHO ARE INTERESTED IN THE AGING OF POPULATIONS OR OF INDIVIDUALS WILL BE MUCH MORE EFFECTIVE IN THEIR WORK IF THEY BECOME FAMILIAR WITH THE SUBJECT MATTER OF THIS BOOK." - JOURNAL OF ORTHOMOLECULAR MEDICINE, 1993, vol.8, No.1, pp.59-60. **********************************THE END********************************  From owner-ageing@net.bio.net Tue Jul 11 23:00:00 1995 Path: biosci!ihnp4.ucsd.edu!news.service.uci.edu!usenet From: KUCI Fan Newsgroups: bionet.molbio.ageing Subject: Re: REGISTRATION IS IN PROGRESS FOR APOPTOSIS SYMPOSIUM Date: 12 Jul 1995 20:49:55 GMT Organization: Unemployed, Inc. Lines: 36 Message-ID: <3u1chj$2lb@news.service.uci.edu> References: NNTP-Posting-Host: curly.bio.uci.edu Mime-Version: 1.0 Content-Type: multipart/mixed; boundary="-------------------------------18977111614357" X-Mailer: Mozilla 1.1N (Macintosh; I; PPC) To: MANEV@SINGER.ASRI.EDU X-URL: news:Pine.3.89.9507070707.A22681-0100000@SINGER.ASRI.EDU This is a multi-part message in MIME format. ---------------------------------18977111614357 Content-Transfer-Encoding: 7bit Content-Type: text/plain; charset=us-ascii MANEV@SINGER.ASRI.EDU wrote: >International Symposium on Oxidative Stress, Apoptosis and Brain Damage >will be held in Pittsburgh, PA from September 21 to 24. >Registration is in progress ($ 250, three days; includes course materials, >welcome reception, continental breakfast, lunch and refreshment breaks >each day). >For information please call: +412-359-4952. > ---------------------------------18977111614357 Content-Transfer-Encoding: 7bit Content-Type: text/plain From: MANEV@SINGER.ASRI.EDU Newsgroups: bionet.molbio.ageing Subject: REGISTRATION IS IN PROGRESS FOR APOPTOSIS SYMPOSIUM Date: 7 Jul 1995 04:52:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Message-ID: International Symposium on Oxidative Stress, Apoptosis and Brain Damage will be held in Pittsburgh, PA from September 21 to 24. Registration is in progress ($ 250, three days; includes course materials, welcome reception, continental breakfast, lunch and refreshment breaks each day). For information please call: +412-359-4952. ---------------------------------18977111614357-- From owner-ageing@net.bio.net Fri Jul 14 23:00:00 1995 Path: biosci!VMSA.CSD.MU.EDU!6534HEINTZT From: 6534HEINTZT@VMSA.CSD.MU.EDU Newsgroups: bionet.molbio.ageing Subject: Aging resources needed Date: 14 Jul 1995 21:27:55 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 22 Sender: daemon@net.bio.net Distribution: world Message-ID: <01HSVMD3EEYE91YJUR@VMS.CSD.MU.EDU> NNTP-Posting-Host: net.bio.net Hello, I need your help. I am writing a book which contains a list of useful resources for senior citizens in all lifestyles. If your organization/company offers a service/product which you believe would be useful to seniors, please E-Mail (6534HEINTZT@VMS.CSD.MU.EDU) the following: Company name Full address Phone numbers Brief (20 words max.) description of product/service. There is NO CHARGE for being listed. Thank you. Rita J. Putnam, author AS YOUR PARENTS AGE - 1994 AS WE AGE - 1995 GOLDEN-AGERS RESOURCE DIRECTORY - 1995 http://www.alpha.net/dci/aging.html From owner-ageing@net.bio.net Fri Jul 14 23:00:00 1995 Path: biosci!daresbury!trane.uninett.no!Norway.EU.net!EU.net!news.sprintlink.net!tank.news.pipex.net!pipex!demon!longevb.demon.co.uk!John From: John de Rivaz Newsgroups: bionet.molbio.ageing Subject: Re: Aging resources needed Date: Sat, 15 Jul 1995 10:46:36 GMT Organization: Myorganisation Lines: 13 Message-ID: <470925683wnr@longevb.demon.co.uk> References: <01HSVMD3EEYE91YJUR@VMS.CSD.MU.EDU> Reply-To: John@longevb.demon.co.uk X-NNTP-Posting-Host: longevb.demon.co.uk X-Broken-Date: Saturday, Jul 15, 1995 10.46.36 X-Newsreader: Newswin Alpha 0.7 There was a book published in 1980 called The Complete Book of Longevity by Rita *Aero* and published by *Putnam*. Is there any connection? -- Sincerely, **************************************** * Publisher of Longevity Report * John de Rivaz * Fractal Report * * details on request * **************************************** **** What is the point of life if it ends in death? **** From owner-ageing@net.bio.net Mon Jul 17 23:00:00 1995 Newsgroups: bionet.molbio.ageing Path: biosci!galaxy.ucr.edu!ratatosk.yggdrasil.com!news.duke.edu!convex!cs.utexas.edu!swrinde!dish.news.pipex.net!pipex!warwick!bsmail!usenet From: Harry Witchel Subject: Pineal gland, ageing, research in US, UK, GDR, Japan Message-ID: Sender: usenet@uns.bris.ac.uk (Usenet news owner) Nntp-Posting-Host: rm2.pys.bris.ac.uk Reply-To: harry.witchel@bristol.ac.uk Organization: Medical School, Bristol, UK X-Newsreader: WinVN 0.91.4 Date: Tue, 18 Jul 1995 12:54:03 GMT Lines: 23 It seems that in the US, UK, Germany, and Japan the thrust of funding in ageing in mammals is in extrinsic causes (eg RG_Cutler (1978) "Evolutionary Biology of Senescence" in _Biology of Aging_ edited by JA Behnke (New York, Plenum) pp. 311-60; and D_Harman (1992) "Free Radical Theory of Aging" _Mutation Research_ 275:257-66) and dietary restriction (eg EJ_Masoro (1992) "A Dietary Key to Uncovering Aging Processes" _News in Physiological Sciences_ 7:157-160). When literature searching I have found conference proceedings from small groups in Russia and Italy suggesting that pineal transplant (or even night-time feeding of melatonin) can lead to increased mean lifespans in rats (eg VA Lesnikov & W Pierpaoli (1994) "Pineal cross transplantation (Old-to-Yound and vice versa) as evidence for an Endogenous Aging Clock" Annals NY Acad. Sciences 719:456-460). With the exception of W Regelson (Piepaoli's collaborator from Richmond, VA) there seems to be no follow up on this important work, especially curious as there is not (to my knowledge) any demonstration in mammals that adding oxygen radical scavengers increases lifespans. I assume that the lack of follow-up in the US, UK, Germany, and Japan is due to the skepticism. Has there been any US pursuit of this idea? Is there evidence for radical scavengers increasing lifespan in mammals? Harry Witchel From owner-ageing@net.bio.net Tue Jul 18 23:00:00 1995 Path: biosci!daresbury!trane.uninett.no!Norway.EU.net!EU.net!howland.reston.ans.net!news.sprintlink.net!news.voicenet.com!cherryhill11.voicenet.com!mortgale From: mortgale@omni.voicenet.com (Morten Gale) Newsgroups: bionet.molbio.ageing Subject: Melatonin Dosage Date: Wed, 19 Jul 1995 21:00:27 GMT Organization: Voicenet - Internet Access - (215)674-9290 Lines: 14 Message-ID: NNTP-Posting-Host: cherryhill11.voicenet.com Summary: Is there a recommended dosage? Keywords: melatonin, dosage X-Newsreader: Trumpet for Windows [Version 1.0 Rev B final beta #4] An article by Janet Raloff in Science News (Vol 147 No. 19, pg 300-301) described several benefits of taking melatonin as an aid for sleep, aging (antioxidant), breast cancer, etc. Does anyone know where I can find more information about the appropriate dosage and timing for using melatonin as an aid for sleeping and anti-aging (I am 70)? I have some 3mg Melatonin tablets from KAL, who suggest 1 - 2 tablets, 20 minutes before going to sleep. Is that the only time that they can be taken? Or can they be taken at other times for their anti-aging benefits? Is there a detrimental consequence of taking more than the recommended dose? Any suggestions for further sources of information would be appreciated. Mort Gale From owner-ageing@net.bio.net Wed Jul 19 23:00:00 1995 Path: biosci!daresbury!trane.uninett.no!Norway.EU.net!EU.net!howland.reston.ans.net!ix.netcom.com!netnews From: pootszu@ix.netcom.com (Susan Patrick ) Newsgroups: bionet.molbio.ageing Subject: DHEA's effects on aging Date: 18 Jul 1995 02:36:17 GMT Organization: Netcom Lines: 45 Distribution: world Message-ID: <3uf6n1$7o6@ixnews2.ix.netcom.com> NNTP-Posting-Host: ix-cin4-08.ix.netcom.com I was recently introduced to several very interesting articles about DHEA, and would like to share them with you. Excerpt From: The New England Journal of Medicine, no date "Scientists are wondering whether they may have at last found the root cause of aging itself. Provoking intense excitement among longevity researchers is a new report from California on a steroid called DHEA (dehydroepiandrosterone) that appears to reduce the risk of heart disease." "In a study of 242 men over age 50, researcher Elizabeth Barrett-Connor at the University of California at San Diego found that those with high levels of DHEA in their blood were only half as likely to die of heart disease as those with relatively little of the hormone. Even with people without heart disease, DHEA seems to protect against early death." "On its own, that's good news. But coming as it does after reports that taking DHEA can prevent or ease a variety of other ills, it may be the strongest evidence yet that a single hormone plays a central role in maintaining human health." Excerpt From: LIFE magazine, October, 1992 Nature believes in overkill. Determined to ensure our survival until we can reproduce, nature has crammed the human organism with backup systems. One of the most effective is DHEA (short for dehydroepiandrosterone), an adrenal hormone that, much like human growth hormone, floods the body while we're young and has various powerful beneficial effects on the human system. As we enter out thirties, production of DHEA begins to ebb. At 50, most people secrete only 30 percent of what they produced when they were young, and the loss can trigger catastrophes. A DHEA deficiency can increase the risk of breast cancer in women and heart attacks in men. But Dr. Arthur Schwarts, 51, a Temple University biologist and leading U.S. autrhority on the hormone, reports that in laboratory animals high dose DHEA feedings reduce body fat by one third, prevent atherosclerosis, alleviate diabetes, reduce the risk of cancer, enhance the immune response, inhibit the development of certain autoimmune diseases and extend the bnormal life span of mice by 20 percent. For more information on DHEA, please e-mail me at pootszu@ix.netcom.com From owner-ageing@net.bio.net Wed Jul 19 23:00:00 1995 Path: biosci!rutgers!uwm.edu!vixen.cso.uiuc.edu!howland.reston.ans.net!torn!newshub.ccs.yorku.ca!shemp15.slip.yorku.ca!kathylee From: kathylee@yorku.ca (Catherine Lee) Newsgroups: bionet.molbio.ageing Subject: Looking for Novel Therapeutic Proteins for Licensing Date: Thu, 20 Jul 1995 12:32:23 GMT Organization: York University Lines: 15 Message-ID: NNTP-Posting-Host: shemp15.slip.yorku.ca X-Newsreader: Trumpet for Windows [Version 1.0 Rev B final beta #4] I am requesting information on any novel therapeutic proteins that are available for licensing for development/ production in E. coli system. The E. coli system has been used to produce bioactive human PTH and human EGF at levels for commercialization. I am interested in finding new or existing peptides or proteins with known or implied therapeutic activity. If you or your colleagues have available or know of such a protein (or proteins), I would be very interested in discussing its future development and/or manufacturing requirements. Please reply via e-mial: kathylee@yorku.ca Thanks for your help in advance. Catherine Lee, Ph.D. From owner-ageing@net.bio.net Fri Jul 21 23:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!news.clark.net!rahul.net!a2i!kaiwan.kaiwan.com!not-for-mail From: jlin@kaiwan009.kaiwan.com (Neptune) Newsgroups: bionet.molbio.ageing Subject: ACAM fall convention announcement Date: 22 Jul 1995 10:28:33 -0700 Organization: KAIWAN Internet (310-527-4279,818-756-0180,909-785-9712,714-638-4133,805-294-9338) Lines: 51 Message-ID: <3urcg1$o4@kaiwan009.kaiwan.com> NNTP-Posting-Host: kaiwan009.kaiwan.com X-Newsreader: TIN [version 1.2 PL2] American College for Advancement in Medicine (ACAM) will hold its fall convention at Colorado Springs, Colorado on November 2-5 1995. Along with Chelation therapy workshop be held on Nov 1-2 1995. The theme of this convention will be: AGING: REDUCING, REVERSING AND COPING WITH ITS EFFECTS. Following are some of the confirmed speakers and topics Jeffery Bland, PhD Physiological Oxidation/Reduction and its Relationship to Biological Aging. Jeffery Blumberg, PhD Recent Advances in Nutrition and Aging Research: Antioxidants, Calcium and other nutrients. LeoGalland, MD The aging gut Richard A. Kunin MD Copper balance and aging Simin Meydani, DVM, PhD Vit B6 and E, and Immune function in the elderly. Richard Passwater, PhD Synergistic Approaches to reducing oxidative and Glycosylation damage reactions of the aging process. ....and much more. Any questions or registration(discount apply to member and advance registrant, before Oct 2). Please contact ACAM 23121 Verdugo Dr. Suite 204 Laguna Hills, CA 92653 Tel: 800-532-3688 or 714-583-7666 -- John Lin *** Save the planet, save the world ! *** e-mail: jlin@kaiwan.com -- John Lin *** Save the planet, save the world ! *** e-mail: jlin@kaiwan.com From owner-ageing@net.bio.net Mon Jul 24 23:00:00 1995 Path: biosci!bcm!news.msfc.nasa.gov!europa.chnt.gtegsc.com!gatech!news.sprintlink.net!news.voicenet.com!cherryhill22.voicenet.com!mortgale From: mortgale@omni.voicenet.com (Morten Gale) Newsgroups: bionet.molbio.ageing Subject: Melatonin Dosage II Date: Mon, 24 Jul 1995 19:07:26 GMT Organization: Voicenet - Internet Access - (215)674-9290 Lines: 36 Message-ID: NNTP-Posting-Host: cherryhill22.voicenet.com Summary: Responses to my first post on this Subject. Keywords: melatonin, dosage X-Newsreader: Trumpet for Windows [Version 1.0 Rev B final beta #4] In an earlier post I asked for information on the appropriate dosage for using melatonin as an aid for sleep and antiaging. I received two email responses which I want to share with others who may have seen the first posting. (Because they were email responses, I won't identify them since I don't know if that is their desire.) A 40 y/o said that she takes 3mg about a half hour before going to bed. This is consistent with what I found from a second source, who offered the following. I found both the book ($18.95) and the magazine ($2.99) at a local Dalton's Book Store. Both were exceptionally informative with respect to current understandings of the effects of melatonin. The magazine article carries most of the information that's in the book. I feel much better informed after reading these sources. The second email response to my post also suggested other sources of Net advice on aging and related topics. These other sources were as follows: Newsgroups: sci.life-extension; sci.med.nutrition; and sci.med.pharmacy WWW Sites: http://pharminfo.com; http:www.usc.edu/dept/nbio/nibs.html; and http://www.hookup.net/mall/aging/agesit59.html. I want to thank those two respondants to my post, and I hope that they don't mind my sharing their information with others in this newsgroup. Mort Gale. From owner-ageing@net.bio.net Mon Jul 24 23:00:00 1995 Newsgroups: bionet.molbio.ageing Path: biosci!lhc!nih-csl!NewsWatcher!user From: Stauffer@codon.nih.gov (Jim Stauffer) Subject: Symposium: Molecular Mechanisms Regulating Skeletal Muscle Plasticity Message-ID: Sender: postman@alw.nih.gov (AMDS Postmaster) Nntp-Posting-Host: 128.231.222.63 Organization: UMN/LDN/NIHCD/NIH Date: Mon, 24 Jul 1995 15:53:08 GMT Lines: 43 Please post or pass along the following announcement: SYMPOSIUM MOLECULAR MECHANISMS REGULATING SKELETAL MUSCLE PLASTICITY September 24-27, 1995; Airlie Conference Center, Airlie, VA. Sponsored by NICHD, NIH. Sessions & speakers will include: MYOBLAST AND MYOFIBRIL DIVERSITY C. Ordahl, B. Wold, N. Rosenthal, L. Leinwand DETERMINATION AND DIFFERENTIATION FACTORS E. Olson, B. Paterson, W. Wright SYNAPTOGENESIS AND PLASTICITY AT THE NMJ J. Lichtman, W. Thompson, S. Burden, Z. Hall MECHANISMS REGULATING FIBER-TYPE PLASTICITY D. Pette, A. Kelly, S. Williams, S. Hauschka, S. Schiaffino, A. Buonanno REGENERATION AND NEUROMUSCULAR DISESASE M. Rudnicki, Z. Yablonka-Reuveni, H. Blau Limited to 150 people. Registration deadline is August 15, 1995. For information on registration and poster sessions contact: Andres Buonanno, Maxine Schaefer or Georgia Schwartz Muscle Plasticity Symposium Building 49, Room 5A-38 NIH, 49 Convent Drive Bethesda, MD 20892-4480 Phone (301) 496-1463 Fax (301) 496-9939 E-Mail: buonanno@helix.nih.gov From owner-ageing@net.bio.net Mon Jul 24 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!swrinde!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: tristan314@aol.com (Tristan314) Newsgroups: bionet.molbio.ageing Subject: Re: Looking for Novel Therapeutic Proteins for Licensing Date: 23 Jul 1995 15:55:00 -0400 Organization: America Online, Inc. (1-800-827-6364) Lines: 2 Sender: root@newsbf02.news.aol.com Message-ID: <3uu9ek$b7q@newsbf02.news.aol.com> References: Reply-To: tristan314@aol.com (Tristan314) NNTP-Posting-Host: newsbf02.mail.aol.com I, too, am looking for any free information that would make me rich! ;-) From owner-ageing@net.bio.net Sun Jul 30 23:00:00 1995 Path: biosci!daresbury!nntp-trd.UNINETT.no!Norway.EU.net!EU.net!howland.reston.ans.net!news.sprintlink.net!uunet!in2.uu.net!hoho.quake.net!xdcrlab.com!user From: xdcrlab@quake.net (Mike Davis) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin Dosage II Date: Mon, 31 Jul 1995 08:01:42 -0700 Organization: XdcrLab Lines: 13 Message-ID: References: NNTP-Posting-Host: xdcrlab.com X-Newsreader: Value-Added NewsWatcher 2.0b24.0+ In article , mortgale@omni.voicenet.com (Morten Gale) wrote: > WWW Sites: http://pharminfo.com; http:www.usc.edu/dept/nbio/nibs.html; and > http://www.hookup.net/mall/aging/agesit59.html. > The VRP melatonin articles are available on my website as is a link to the LEF website and their articles. -- Mike Davis ((( xdcrlab@quake.net ))) ((( Ultrasonic Devices ))) Discnt.Suppl.List;Articles: http://www.quake.net/~xdcrlab/hp.html Ultrasnd.Tchnlgy: http://www.quake.net/~xdcrlab/Ultrasound.html