From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!psgrain!nntp.teleport.com!jor From: jor@teleport.com (Jo Robinson) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin study Date: 2 Dec 1995 01:51:07 GMT Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 45 Message-ID: <49obeb$2q9@maureen.teleport.com> References: NNTP-Posting-Host: linda.teleport.com X-Newsreader: TIN [version 1.2 PL2] Kevin Goldstein (keving@primenet.com) wrote: : Found this on misc.fitness.weights. Jo, are you, or anyone else on here, : familiar with this study? Without knowing more about it, it's impossible to : know if the study is valid. Kevin, no I haven't heard of this study. What is interesting about it however, is that saline injections may increase melatonin -- which is what Maestroni has found in his just completed mouse diabetes trial. Now isn't that an interesting confounding factor, given all the various types of studies that have used saline injections as a control. Stress, of course, is also likely to have an effect on melatonin production. Now, for humans to take a melatonin tablet is decidely non- stressful. and taking melatonin has had a definite effect on the body's circadian clock. I don't believe that a placebo-controlled study has been done. However, Al Lewy has shown that taking melatonin at different times of day shifts the circadian clock quite reliably in different directions according to what he calls a phase response curve. It is highly unlikely that could be a placebo effect. As a side issue, it's interesting to me the number of people who want to dismiss melatonin as a placebo effect. I responded to some guy on the pharmacy newsgroup who said that melatonin is broken down in the stomach and therefore cannot enter the bloodstream. Thus, he declared, all the 1480 human studies involving melatonin were sham studies. A psychiatrist assured me that melatonin was a protein (which this group knows it is not) and therefore was too large to cross the blood-brain barrier. Therefore, no mood altering effect. I was just on a talk show with an M.D. who told hundreds of thousands of viewers that "no human studies have been conducted on melatonin" therefore the claims being made were all wishful thinking. He even had the nerve to pat me on the arm, call me "dear," and assure me that he had read "all the original research." I suggested that we sit down right then and there and discuss the literature, but, "to his regret", he had another appointment. Amazing. Jo For a melatonin FAQ, go to http://www.teleport.com/~jor -- +-----------------------------------+-----------------------------------------+ | Jo Robinson | jor@teleport.com | | (503)284-4676 | 2826 NE 18th Portland, OR 97212 | +-----------------------------------+------------------------------------y-----+ From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.sprintlink.net!dca.net!news From: thomass@dca.net (Rockit) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin Brands Date: 2 Dec 1995 02:49:49 GMT Organization: DCANet - Delaware Common Access Network Lines: 28 Message-ID: <49oesd$gaa@dca.net> References: <49hphh$m3p@news.cuny.edu> NNTP-Posting-Host: ppp-1009.dca.net X-Newsreader: WinVN 0.92.6+ In article <49hphh$m3p@news.cuny.edu>, Etha Schlemermeyer says: > >After reading several postings about >negative experiences with Melatonin >and also experiences some of my friends >had I wonder if the addition of B Vitamin >may play a role? All of the people I >talked to who had negative experiences >with M took a preparation that was combined >with B Vitamin. >Also, I must admit that "the pure stuff" >taken from labs in "the early days" was >definitely better than any prep on the >market. I hate pills, and don't under- >stand the reason for putting fillers in >with the prep, at least not that much. > >Etha I first took a preparation that includud Vitamin B6. I woke up throughout the night each night. I switched to a brand without B6 and sleep soundly every night since. I also happen to be hypersensitive to most stimulants...for example, Nyquil keeps me awake all night because of the small amount of stimulants in it. Don't know if this has a bearing on the B6 reaction or not. Any speculation from the experts? From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!MAILHOST.TCS.TULANE.EDU!abarroc From: abarroc@MAILHOST.TCS.TULANE.EDU Newsgroups: bionet.molbio.ageing Subject: unsuscribe Date: 1 Dec 1995 21:17:42 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 6 Sender: daemon@net.bio.net Distribution: world Message-ID: Reply-To: abarroc@mailhost.tcs.tulane.edu NNTP-Posting-Host: net.bio.net unsuscribe AGEING Albert Barrocas Have a nice day. abarroc@mailhost.tcs.tulane.edu Phone:504-244-5075Fax 504-244-4580 24hr access phone504241-4547 From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in1.uu.net!prodigy.com!usenet From: BWXF27B@prodigy.com (Larry Sharp) Newsgroups: bionet.molbio.ageing Subject: Re: 1/2 mg melatonin optimal for anti-aging? Date: 2 Dec 1995 06:07:14 GMT Organization: Prodigy Services Company 1-800-PRODIGY Lines: 38 Distribution: world Message-ID: <49oqei$15ca@usenetz1.news.prodigy.com> References: NNTP-Posting-Host: inugap4.news.prodigy.com X-Newsreader: Version 1.2 jtieber@pobox.com (John Tieber) wrote: > > >From the most recent (January 1996) issue of Life Extension Magazine (page 16): > >³Scientists whoıve conducted melatonin research have emphasized in several >new books that healthy people who donıt suffer from insomnia _may_ only >need 500 mcg [1/2 mg] of melatonin per night for optimal antiaging >benefits.² > >Later reference to _The Melatonin Miracle_ suggests that the scientists >referred to are Walter Pierpaoli, MD, PhD; and William Regelson, MD. > >This is the first mention Iıve seen that 1/2 mg per night might be optimal >for anti-aging. Per this, Life Extension Foundation now offers a 500 mcg >size (6 month+ supply:$14). > >I donıt have trouble sleeping, and would rather spend about $25 per year >for my 99.9% purity melatonin than what Iım spending now. > >Can anyone contradict the claim that 500 mcg per night is optimal for >anti-aging purposes? If not, I guess Iıll have to buy the book, hopefully >using some of the money I will then save by reducing my melatonin >purchases. Experiments with melatonin and immune response appear to be dose dependent up to around 10 mg. Since one of the fundamental aging clocks is the decline of the immune system a higher dose would seem prudent until lifespan vs dose experiments have been completed. I think the 1/2 mg dose is the knee in the curve for the antioxidantproperty of melatonin. From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: lcuster@aol.com (Lcuster) Newsgroups: bionet.molbio.ageing Subject: Re: DNA- (Telomerase) Date: 2 Dec 1995 08:30:07 -0500 Organization: America Online, Inc. (1-800-827-6364) Lines: 29 Sender: root@newsbf02.news.aol.com Message-ID: <49pkcv$h5i@newsbf02.news.aol.com> References: <49hpno$m3p@news.cuny.edu> NNTP-Posting-Host: newsbf02.mail.aol.com X-Newsreader: AOL Offline Reader Etha, It sounds like you're describing telomeres. Eukaryotic chromosomes are capped by repeated sequences that protect the ends of the chromosomes from enviromental damage. These repeated sequences are specific for each individual. These repeating sequences are added by an enzyme called telomerase, after DNA replication. Part of the telomerase enzyme is an RNA component that acts as a primer for the telomere repeat sequences. Teleomerase activity and teleomere length decrease with age. Very short telomeres result in genetic instablity and/or cell death. Two articles recently appeared in Science. Try reading those. If you need more information look at the article references. Science 269:1236-1241 and 269:1267-1272 Happy Reading !!! *************************************************** Laura Custer Dept. of Chemistry The American University Washington, D.C. Lcuster@aol.com ************************************************** From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!fdn.fr!jussieu.fr!univ-lyon1.fr!in2p3.fr!swidir.switch.ch!nntp.coast.net!news00.sunet.se!sunic!news99.sunet.se!newsfeed.tip.net!peroni.ita.tip.net!venere.inet.it!usenet From: valentino@peg.it (valentino) Newsgroups: bionet.molbio.ageing Subject: cause of ageing Date: 1 Dec 1995 21:46:18 GMT Organization: pegaso Lines: 4 Message-ID: <49nt3a$22o6@venere.inet.it> NNTP-Posting-Host: 194.20.207.105 Mime-Version: 1.0 Content-Type: Text/Plain; charset=ISO-8859-1 X-Newsreader: WinVN 0.99.5 greetings, I would like to know if it's absurd the hypotesis that the ageing process is caused by viruses. From owner-ageing@net.bio.net Fri Dec 01 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!howland.reston.ans.net!news.sprintlink.net!nntp.primenet.com!kg.com!keving From: keving@primenet.com (Kevin Goldstein) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: Sat, 2 Dec 1995 12:37:09 MST Organization: Primenet Lines: 59 Distribution: world Message-ID: References: <199511271739.JAA20145@jeeves.ucsd.edu> <49gh7j$i48@maureen.teleport.com> <49o18g$rf5@maureen.teleport.com> NNTP-Posting-Host: kg.com X-Newsreader: Trumpet for Windows [Version 1.0 Rev B final beta #4] In article <49o18g$rf5@maureen.teleport.com> jor@teleport.com (Jo Robinson) writes: >From: jor@teleport.com (Jo Robinson) >Subject: Re: Melatonin-dose for anti-aging >Date: 1 Dec 1995 22:57:20 GMT >Kevin Goldstein (keving@primenet.com) wrote: >: In article <49gh7j$i48@maureen.teleport.com> jor@teleport.com (Jo Robinson) >writes: >: * snip * >: > If you want to continue to experiment with melatonin, I suggest >: >that you switch brands (in case the #2 explanation applies) and take >: >a much smaller dose, perhaps 500 micrograms --- 0.5 milligrams. I have >: >a good friend who took a 3 mg. dose of KAL brand melatonin and was >: >awake all night long. A very bizarre experience. She switched to >: >another brand (Life Extension) and dropped the dose down to 1 mg. >: >She slept like a log and has had no trouble ever since. >: *snip* >: >| Jo Robinson | jor@teleport.com >: A question on dosages, Jo. How much are you feeding your rats (mice?) in your >: experiement? > ** Mice. They get 1 mg of melatonin per liter of water. I take >the melatonin water away in the daytime so they only have the hormone at >night. >/l. > And do you know what that amounts to in mg/kg? > The melatonin-treated mice weigh, on average, 37 grams when >last weighed. The control mice -- 33.3 grams. If you've visited my >home page recently, you can see the difference in size at a gland. > Also, do you know >: what the doses were in some of the published studies that showed life >: extension properties for mice? (Again in mg/kg, since I don't know how much >: those critters drink in a day.) > I surely do. In the Maestroni/ Pierpaoli experiments, the mice >were given 10 micrograms per ml. In the Oaknin-Bendahan study, the rats >were given 4 mg/liter. >: Well, OK, that was three questions. > That's all? > Jo >To see the mice, go to http://www.teleport.com/~jor >-- >+-----------------------------------+-----------------------------------------+ >| Jo Robinson | jor@teleport.com | >| (503)284-4676 | 2826 NE 18th Portland, OR 97212 | >+-----------------------------------+------------------------------------y-----+ I'm still not clear on how much total melatonin they get: am I to assume that they drink a liter of water a day? (!!!) Without knowing how much they drink in a night, I can't calculate their dosage in mg/kg. -Kevin Goldstein From owner-ageing@net.bio.net Sat Dec 02 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!newsfeed.internetmci.com!psgrain!nntp.teleport.com!jor From: jor@teleport.com (Jo Robinson) Newsgroups: bionet.molbio.ageing Subject: Anti-aging Conference Date: 3 Dec 1995 16:39:57 GMT Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 9 Message-ID: <49sjst$6hb@maureen.teleport.com> NNTP-Posting-Host: linda.teleport.com X-Newsreader: TIN [version 1.2 PL2] I will be at the conference. It would be nice to meet some of you in person. Jo -- +-----------------------------------+-----------------------------------------+ | Jo Robinson | jor@teleport.com | | (503)284-4676 | 2826 NE 18th Portland, OR 97212 | +-----------------------------------+------------------------------------y-----+ From owner-ageing@net.bio.net Sat Dec 02 22:00:00 1995 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.ageing Subject: IMPORTANT: BIOSCI miniFAQ Date: 3 Dec 1995 02:00:49 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 196 Sender: daemon@net.bio.net Distribution: world Message-ID: <199512031000.CAA08081@net.bio.net> NNTP-Posting-Host: net.bio.net This is a new "miniFAQ" designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. Contents: -------- 1) What to do about "spams," i.e., junk mail, ads, etc. 2) Examples of subscribing and unsubscribing to the mailing lists. 3) How to access BIOSCI/bionet newsgroup archives. 4) The BIOSCI user address and research interest directory. 1) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups) and mailing lists. The same postings are distributed on both media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the newsgroups from about 95% of the spams that are being sent to date. This means that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings. Unfortunately there are easy ways for determined spammers to override the moderation mechanism. We are working on new systems to provide access to our newsgroups over the WWW. These should be available soon, probably November 1995, and will allow you to use your Web browser to look at the news postings. While this will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. 2) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. 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For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 3) How to access BIOSCI/bionet newsgroup archives. -------------------------------------------------- Back postings of all BIOSCI/bionet newsgroups can be found on the World Wide Web at URL http://www.bio.net/. There are several searchable newsgroup indices at this site. E-mail users can search the BIOSCI archives by using our waismail e-mail server. For instructions send the message help to waismail@net.bio.net. Leave the Subject: line blank (anything entered on the Subject: line is ignored). 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From owner-ageing@net.bio.net Sat Dec 02 22:00:00 1995 Path: biosci!avslag.aeiveos.ac.ru!gavrilov From: gavrilov@avslag.aeiveos.ac.ru ("Leonid A.Gavrilov") Newsgroups: bionet.molbio.ageing Subject: Call to American Colleagues Date: 2 Dec 1995 12:56:04 -0800 Organization: Gavrilov Lines: 44 Sender: daemon@net.bio.net Distribution: world Message-ID: Dear Colleagues, Some months ago my scientific colleague and the key coauthor of very interesting study: HUMAN LONGEVITY: PAST, PRESENT AMD FUTURE published by Longevity Report (1995, vol.9,No.52,p.3-4), Dr.Yulia Kushnareva, Ph.D. has left Russia (Moscow) for USA (Baltimore). During provisional period of cultural adaptation Dr.Yulia Kushnareva is trying to continue her previous important scientific research on human longevity at her new American home. I wonder if any of American colleagues is able to support her studies just by sending her any old primitive computer for computerization of longevity data ? Her address is: Dr.Yulia E.Kushnareva, Ph.D. 3 Dalecrest Ct., Apt.102 Timonium MD 21093, USA Tel.: +(1)-(410)-560-7167 You can find her CV and photo at: http://aeiveos.wa.com/au/gavrilov-la/yula_cv.html or http://alpha.genebee.msu.su/au/gavrilov-la/yula_cv.html She is really an outstanding scientist an the most wonderful lady in the world I have ever seen. If you are able to help her please do it ! Thank you in advance, Dr.Leonid A.Gavrilov, Ph.D. Principal Research Scientist Moscow State University Moscow,Russia From owner-ageing@net.bio.net Sat Dec 02 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!newsfeed.internetmci.com!psgrain!nntp.teleport.com!jor From: jor@teleport.com (Jo Robinson) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: 3 Dec 1995 16:38:36 GMT Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 19 Distribution: world Message-ID: <49sjqc$6hb@maureen.teleport.com> References: <199511271739.JAA20145@jeeves.ucsd.edu> <49gh7j$i48@maureen.teleport.com> <49o18g$rf5@maureen.teleport.com> NNTP-Posting-Host: linda.teleport.com X-Newsreader: TIN [version 1.2 PL2] Kevin Goldstein (keving@primenet.com) wrote: : I'm still not clear on how much total melatonin they get: am I to assume that : they drink a liter of water a day? (!!!) Without knowing how much they drink : in a night, I can't calculate their dosage in mg/kg. Kevin - You're right, there's no way to calculate how much they are getting when using this delivery method. Maestroni in Switzerland just completed a study in which he gave mice melatonin by injection. I'll e-mail him and ask what dose he was using. Jo Jo -- +-----------------------------------+-----------------------------------------+ | Jo Robinson | jor@teleport.com | | (503)284-4676 | 2826 NE 18th Portland, OR 97212 | +-----------------------------------+------------------------------------y-----+ From owner-ageing@net.bio.net Sat Dec 02 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!newsfeed.internetmci.com!psgrain!nntp.teleport.com!jor From: jor@teleport.com (Jo Robinson) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin Brands Date: 3 Dec 1995 16:32:34 GMT Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 50 Message-ID: <49sjf2$6hb@maureen.teleport.com> References: <49hphh$m3p@news.cuny.edu> <49oesd$gaa@dca.net> NNTP-Posting-Host: linda.teleport.com X-Newsreader: TIN [version 1.2 PL2] Rockit (thomass@dca.net) wrote: : In article <49hphh$m3p@news.cuny.edu>, Etha Schlemermeyer says: : > : >After reading several postings about : >negative experiences with Melatonin : >and also experiences some of my friends : >had I wonder if the addition of B Vitamin : >may play a role? All of the people I : >talked to who had negative experiences : >with M took a preparation that was combined : >with B Vitamin. : >Also, I must admit that "the pure stuff" : >taken from labs in "the early days" was : >definitely better than any prep on the : >market. I hate pills, and don't under- : >stand the reason for putting fillers in : >with the prep, at least not that much. : > : >Etha : I first took a preparation that includud Vitamin B6. I woke up throughout : the night each night. I switched to a brand without B6 and sleep soundly : every night since. : I also happen to be hypersensitive to most stimulants...for example, : Nyquil keeps me awake all night because of the small amount of stimulants : in it. Don't know if this has a bearing on the B6 reaction or not. : Any speculation from the experts? I've heard the very same complaints about melatonin laced with B-6. THere's no earthly reason to put B-6 in those preparations (although it might help with the conversion of tryptophan to serotonin to melatonin, you are already supplying the body with melatonin.) I have also heard complaints about a brand called Source Natural. THere are a number of companies that are selling melatonin as pure as it comes (according to their last assays). THis list inclues Life Extension, ALlergy Research and Cardiovascular Research. THey are all mail order companies. (I list their 1-800 numbers on my home page http://www.teleport.com/~jor.)--Neither Reiter nor I have any connection with a melatonin supplier. Jo Coauthor, Melatonin: Your Body's Natural Wonder Drug +-----------------------------------+-----------------------------------------+ | Jo Robinson | jor@teleport.com | | (503)284-4676 | 2826 NE 18th Portland, OR 97212 | +-----------------------------------+------------------------------------y-----+ From owner-ageing@net.bio.net Sun Dec 03 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in1.uu.net!news.ios.com!news From: John Leonard Newsgroups: bionet.molbio.ageing Subject: Reduced caloric intake and lifespan Date: Sun, 03 Dec 1995 16:12:43 -0500 Organization: 12th of Nov, Inc Lines: 3 Message-ID: <30C212CB.2A95@tribeca.ios.com> NNTP-Posting-Host: ppp-68.ts-6.hck.idt.net Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.0b3 (Win95; I) Is Reduced caloric intake the only proven way to increase lifespan in laboratory animals? According to what I've read, it is, and I would like to see more about this subject, from those who have some expertise. From owner-ageing@net.bio.net Sun Dec 03 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!psgrain!nntp.teleport.com!jor From: jor@teleport.com (Jo Robinson) Newsgroups: bionet.molbio.ageing Subject: Re: Reduced caloric intake and lifespan Date: 4 Dec 1995 19:04:32 GMT Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 31 Message-ID: <49vgo0$lhi@maureen.teleport.com> References: <30C212CB.2A95@tribeca.ios.com> NNTP-Posting-Host: linda.teleport.com X-Newsreader: TIN [version 1.2 PL2] John Leonard (leonardj@tribeca.ios.com) wrote: : Is Reduced caloric intake the only proven way to increase lifespan in : laboratory animals? According to what I've read, it is, and I would like to : see more about this subject, from those who have some expertise. Melatonin has been shown to increase lifespan in both mice and rats - - although I don't believe anyone has shown that it increases *maximum* lifespan.Interestingly, calorie restriction -- the most reliable way to increase maximum lifespan in animals -- results in preservation of pineal function. In others words, these calorie-restricted animals continue to produce relatively high amounts of melatonin into old age. [R. J. Reiter "Food restriction retards aging of the pineal gland" Brain Research 1991; 545:66-72] Something that is important about melatonin as a potential anti-aging strategy is that treatment can be initiated in animals at an old age and still be effective. Calorie restriction -- the "fast and you'll last" theory of prolonging youth -- is most effective when begun at an early age. Another proven way to increase lifespan is to prevent free radical damage by increasing the production of endogenous antioxidants or by restricting movement -- which results in a lower consumption of oxygen and, thereby, a lower production of free radicals. (Couch potatoes take note.) [Yu, B.P Free Radicals IN Aging (Boca Raton:CRC Press, 1993] Jo +-----`~------------------------------+-----------------------------------------+ Jo Robinson jor@teleport.com Co-author, with Russel J. Reiter- MELATONIN: Your Body's Natural Wonder Drug For a melatonin FAQ, go to: http://www.teleport.com/~jor (Note: I have no financial connection with any melatonin supplier.) +-----------------------------------+-----------------------------------------+ From owner-ageing@net.bio.net Sun Dec 03 22:00:00 1995 Path: biosci!agate!news.ucdavis.edu!library.ucla.edu!info.ucla.edu!newsfeed.internetmci.com!tetsuo.communique.net!usenet From: treasure.mountain@mail.sstar.com (Treasure Mountain Electronic Publications) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin+B-6 Date: Mon, 04 Dec 1995 16:22:34 GMT Organization: Treasure Mountain Electronic Publications Lines: 23 Message-ID: <49v75e$1us4@tetsuo.communique.net> References: <199512011436.GAA10074@jeeves.ucsd.edu> NNTP-Posting-Host: s3.sstar.com X-Newsreader: Forte Free Agent 1.0.82 hoschek@JEEVES.UCSD.EDU (Gisela Hoschek) wrote: >>> Gisela Hoschek (hoschek@JEEVES.UCSD.EDU) wrote: >>> : To keep the discussion going I would like to add my experience. I only took >>> : melatonin twice, seeking help to fall asleep. I used a formulation of 2.5 >>> : mg melatonin with 500 microgram Vitamin B-6 per tablet, sublingual. My >>> : experience was not pleasant. >>>>>CUT>>> >>>B-6 causes you to dream alot and remember them. CUT. Ron Blue> >>Yes, I had a very vivid, scary, and repeating dream. But why is B-6 >>included with Melatonin? >>Gisela If I remember correctly (maybe an 80% likelihood), Adele Davis reported that vivid dreams associated with B6 actually resulted from not taking magnesium with the vitamin. At least in some people, magnesium is essential when taking B6. Anyone know anything else about this? From owner-ageing@net.bio.net Sun Dec 03 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!newsfeed.internetmci.com!news.sprintlink.net!gate.net!clwfl2-52.gate.net!dhealth From: dhealth@gate.net (diane hein) Newsgroups: bionet.molbio.ageing Subject: Aging and loss of strength...why? Date: Mon, 4 Dec 1995 18:25:08 Organization: CyberGate, Inc. Lines: 11 Message-ID: NNTP-Posting-Host: clwfl2-52.gate.net X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] I recently read the book "How and Why We Age" but it really did not answer my question. I am trying to research the causes of loss of strength as we age...to the point of being "frail" should we live that long. Does anyone know why we lose strength? Thank you. D. Hein From owner-ageing@net.bio.net Sun Dec 03 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.sprintlink.net!gate.net!clwfl2-52.gate.net!dhealth From: dhealth@gate.net (diane hein) Newsgroups: bionet.molbio.ageing Subject: This is a test only for posting Date: Mon, 4 Dec 1995 17:57:35 Organization: CyberGate, Inc. Lines: 1 Message-ID: NNTP-Posting-Host: clwfl2-52.gate.net X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] This is a test only. From owner-ageing@net.bio.net Sun Dec 03 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!newsfeed.direct.ca!van-pm-0803.direct.ca!user From: wtriex@direct.ca (Walt Lazaruk) Newsgroups: bionet.molbio.ageing Subject: ANY DOCTORS OUT THERE!!! Date: 4 Dec 1995 03:14:32 GMT Organization: Triex Corp. Lines: 20 Message-ID: NNTP-Posting-Host: 204.174.243.213 I am a 51 year old professional that recently retired because of spinal nerve shear and possible brain stem compression due to a whiplash/concussion. I am coping with the perciptating symptoms though I get tired easily. My hemoglobin is apparently high ( which I understand evolves from a system that has to modify itself to correct the amount of oxygen intake into the cells.) I recently found out that my iron content in my body is approx 30 percent higher than the norm. It made sense to me to accomadate a oxygen supplement that (I think) is making me feel better. ( I use it with my stair stepper for approx 40 min a day) I guess the question I have is ... am I helping or harming my situation.. Annonymous replies welcome.. thanks in advance.. rl. From owner-ageing@net.bio.net Mon Dec 04 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.sprintlink.net!gate.net!clwfl2-52.gate.net!dhealth From: dhealth@gate.net (diane hein) Newsgroups: bionet.molbio.ageing Subject: Nitrogen balance...how can we measure this? Date: Mon, 4 Dec 1995 18:39:02 Organization: CyberGate, Inc. Lines: 10 Message-ID: NNTP-Posting-Host: clwfl2-52.gate.net X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] 1. Would anyone know how ot measure nitrogen balance? 2. What are the clinical symptoms of loss of nitrogen balance? Thank you. D. Hein From owner-ageing@net.bio.net Mon Dec 04 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!psgrain!nntp.teleport.com!linda.teleport.com!jor From: Jo Robinson Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: Tue, 5 Dec 1995 09:02:16 -0800 Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 40 Message-ID: References: <199511271739.JAA20145@jeeves.ucsd.edu> <49gh7j$i48@maureen.teleport.com> <49o18g$rf5@maureen.teleport.com> <49sjqc$6hb@maureen.teleport.com> <199512051656.IAA14750@PEAK.ORG> NNTP-Posting-Host: linda.teleport.com Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII In-Reply-To: <199512051656.IAA14750@PEAK.ORG> On Tue, 5 Dec 1995, David Gore wrote: > In article <49sjqc$6hb@maureen.teleport.com>, jor@teleport.com says... > > > >Kevin Goldstein (keving@primenet.com) wrote: > > > > > >: I'm still not clear on how much total melatonin they get: am I to assume > that > >: they drink a liter of water a day? (!!!) Without knowing how much they > drink > >: in a night, I can't calculate their dosage in mg/kg. > > > > Kevin - You're right, there's no way to calculate how much they > >are getting when using this delivery method. Maestroni in Switzerland > >just completed a study in which he gave mice melatonin by injection. I'll > >e-mail him and ask what dose he was using. > > Jo > Why not weigh the water each evening and each morning? The difference would > be how much water they drank (you may have to allow for some evaporation). > Dave Gore > That would work. THe problem is, my "study" is far too small (10 mice in all) to come up with significant data. As I explained in an earlier posting, I designed this study to come up with pilot data to prompt researchers in the field to do it in a full-scale version. I cannot believe that no U.S. researchers have conducted an anti-aging experiment involving melatonin --- all the while they cast aspersions upon the studies done outside the U.S. Jo > +-----------------------------------+-----------------------------------------+ Jo Robinson jor@teleport.com Co-author, with Russel J. Reiter- MELATONIN: Your Body's Natural Wonder Drug For a melatonin FAQ, go to: http://www.teleport.com/~jor (Note: I have no financial connection with any melatonin supplier.) +-----------------------------------+-----------------------------------------+ From owner-ageing@net.bio.net Mon Dec 04 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!nntp.coast.net!harbinger.cc.monash.edu.au!news.cs.su.oz.au!metro!OzEmail!usenet From: Peter Hynes Newsgroups: bionet.molbio.ageing Subject: Staining Test for Senescent Cells Date: 5 Dec 1995 19:06:57 GMT Organization: OzEmail Pty Ltd - Australia Lines: 13 Message-ID: <4a258i$2na@oznet03.ozemail.com.au> NNTP-Posting-Host: slmel3p46.ozemail.com.au Anybody seen the brief report in "New Scientist", 7\10\95 by one Jane Itzhaki which refers to Proc. Nat. Acad. Sci., v92, 9363 and tells about a simple staining test fot senescent mammalian cells? Apparently it detects a modified form of B-galactosidase. Seems to me it would be fantastic as a tool in researching tissue culture senescence. Does anybody know if a kit\reagents are commercially available yet? From owner-ageing@net.bio.net Tue Dec 05 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!news00.sunet.se!sunic!news99.sunet.se!newsfeed.tip.net!peroni.ita.tip.net!venere.inet.it!usenet From: valentino@peg.it (valentino) Newsgroups: bionet.molbio.ageing Subject: questions Date: 5 Dec 1995 22:26:23 GMT Organization: pegaso Lines: 6 Message-ID: <4a2guf$1jc8@venere.inet.it> NNTP-Posting-Host: 194.20.207.103 Mime-Version: 1.0 Content-Type: Text/Plain; charset=ISO-8859-1 X-Newsreader: WinVN 0.99.5 Today I'm a 19 years old boy. I would like to know how much ageing treatments are stimated to slow the process (about %). I would like to know if things are improving so fastly that I've got a chance of not becoming an old man too. From owner-ageing@net.bio.net Tue Dec 05 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.compuserve.com!news.production.compuserve.com!news From: susan klee <103035.262@CompuServe.COM> Newsgroups: bionet.molbio.ageing Subject: Re: PROZAC Date: 6 Dec 1995 07:40:43 GMT Organization: CompuServe, Inc. (1-800-689-0736) Lines: 10 Message-ID: <4a3hdr$ima$1@mhafc.production.compuserve.com> References: Rebecca Johnson asks for latest info on Prozac: May I recommend that you contact PLANETREE at 415/673-4964 Tu-Sat 11-5, PT except WE 11-7. With the help of your credit card, they will do one of two different kinds of literature searches for you: the $35. model they do a computer search and send you abstracts. For $100., they'll search more data bases and send you about 60 pp. One of the great things about Planetree is: when you call to request your search, the person at the Planetree end of the phone helps you narrow your topic by asking very good questions. From owner-ageing@net.bio.net Tue Dec 05 22:00:00 1995 Path: biosci!daresbury!nntp-trd.UNINETT.no!Norway.EU.net!EU.net!howland.reston.ans.net!vixen.cso.uiuc.edu!uwm.edu!reuter.cse.ogi.edu!engr.orst.edu!news.orst.edu!news.PEAK.ORG!usenet From: dgore@peak.org (David Gore) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: 5 Dec 1995 16:54:06 GMT Organization: CS Outreach Services--PEAK, Corvallis, Oregon, USA Lines: 20 Distribution: world Message-ID: <4a1tff$m0t@odo.PEAK.ORG> References: <199511271739.JAA20145@jeeves.ucsd.edu> <49gh7j$i48@maureen.teleport.com> <49o18g$rf5@maureen.teleport.com> <49sjqc$6hb@maureen.teleport.com> Reply-To: dgore@peak.org NNTP-Posting-Host: seuss.peak.org Mime-Version: 1.0 X-Newsreader: WinVN 0.93.14 In article <49sjqc$6hb@maureen.teleport.com>, jor@teleport.com says... > >Kevin Goldstein (keving@primenet.com) wrote: > > >: I'm still not clear on how much total melatonin they get: am I to assume that >: they drink a liter of water a day? (!!!) Without knowing how much they drink >: in a night, I can't calculate their dosage in mg/kg. > > Kevin - You're right, there's no way to calculate how much they >are getting when using this delivery method. Maestroni in Switzerland >just completed a study in which he gave mice melatonin by injection. I'll >e-mail him and ask what dose he was using. > Jo Why not weigh the water each evening and each morning? The difference would be how much water they drank (you may have to allow for some evaporation). Dave Gore From owner-ageing@net.bio.net Tue Dec 05 22:00:00 1995 Path: biosci!LEX.LCCC.EDU!rcb1 From: rcb1@LEX.LCCC.EDU (Ron Blue) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: 6 Dec 1995 10:46:11 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 10 Sender: daemon@net.bio.net Distribution: world Message-ID: References: NNTP-Posting-Host: net.bio.net On Tue, 5 Dec 1995, Jo Robinson wrote: >>>CUT>>>>>> > That would work. THe problem is, my "study" is far too small (10 mice > in all) to come up with significant data. >>>>CUT>>> I disagree. If the effect is strong it will show up. If the effect is weak it will require thousands of mice to see it. Such a weak effect has little practicial importance. So small sample sizes should be preferred to pick up important effects. Ron Blue From owner-ageing@net.bio.net Tue Dec 05 22:00:00 1995 Path: biosci!LEX.LCCC.EDU!rcb1 From: rcb1@LEX.LCCC.EDU (Ron Blue) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: 6 Dec 1995 09:48:23 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 10 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <4a1tff$m0t@odo.PEAK.ORG> NNTP-Posting-Host: net.bio.net On 5 Dec 1995, David Gore wrote: > Why not weigh the water each evening and each morning? The difference would > be how much water they drank (you may have to allow for some evaporation). > Dave Gore Mice probably get a lot of their water from their food, not by drinking water. This would be a poor operational definition. Maybe you should mix it in the food ( a few pellets) if they eat them they get the rest of the food. Ron Blue From owner-ageing@net.bio.net Tue Dec 05 22:00:00 1995 Path: biosci!daresbury!not-for-mail From: ene@argo.gslis.ucla.edu (Efthimis N. Efthimiadis) Newsgroups: bionet.molbio.ageing Subject: conference on east & west medicine; Feb'96 Date: 6 Dec 1995 08:44:45 -0000 Lines: 121 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <4a3l5t$gaq@mserv1.dl.ac.uk> Original-To: east-west-med@argo.gslis.ucla.edu To: All physicians, nurses and other medical professionals Subject: Conference on Integrative East-West Medicine Date: February 14-17, 1996 (Wednesday to Saturday). Good News! The UCLA Center for East-West Medicine, UCLA School of Medicine presents the "International Conference on Integrative East-West Medicine '96, Incorporating Traditional Chinese Medicine in your Practice to Enhance Patient Care" (Sponsored by: UCLA School of Medicine Office of Continuing Medical Education and UCLA Center for Pacific Rim Studies) at the Miramar Sheraton Hotel, 101 Wilshire Boulevard, Santa Monica, California 90401, February 14-17, 1996 (Wednesday to Saturday). The conference chairman is Center Director Ka Kit Hui, M.D., F.A.C.P., Associate Professor of Medicine, UCLA School of Medicine. Conference Description: This four-day intensive clinically- oriented conference is designed for physicians and other health- care professionals interested in learning about traditional Chinese Medicine (TCM) and in incorporating this system of medicine into their practice and lifestyle. The focus will be on modern concepts and applications of TCM as well as its practical synergistic integration with modern western medicine in clinical care. The case discussion format with demonstration and hands-on experience using patients and cases from the Center clinic will be used throughout this educational event to: 1) Illustrate the similarities and differences between traditional Chinese medicine and modern western medicine as well as their respective strengths and weaknesses in their approach to patients. 2) Show how integration of the two systems of medicine can be utilized to improve patient care. 3) Optimize the learning of essential acupuncture points, Chinese herbs and formulas as well as health-promoting TCM mental and physical exercise. During this conference, discussion of modern research findings, sharing of clinical pearls, hands-on teaching and demonstrations with patients will be delivered by an international panel of faculty who are experienced physicians/clinical investigators/educators well-versed in integrative East-West medicine. Attendees will also learn some simple health enhancing exercises and methods for their own use. Objectives: At the conclusion of the conference, the participants will acquire new clinical problem-solving ideas and skills from TCM that they can easily apply to patient management. These concepts and techniques have been taught to medical students and residents and used successfully in the Center clinic in patient care at UCLA. At the end of the first two days, participants will be able to: 1) have a basic understanding of the theory, diagnostic skills and treatment principles and techniques used in TCM 2) understand how to integrate TCM with conventional medicine in optimizing patient care, and 3) appreciate the progress of modern research on TCM and integrative East-West medicine. The one-day hands-on session involving acupuncture will familiarize participants with the location and effects of 20 key acupuncture points as well as their application in the treatment of medical conditions commonly encountered in clinical practice. The one-day in-depth session on Chinese herbal medicine will allow participants to master the properties and effects of 20 commonly used herbs and 10 herbal formulas as well as their application in the treatment of common medical problems. Attendees are encouraged to bring cases for discussion. Who should attend: Primary care physicians, internal medicine specialists, pain specialists, nurses, dietitians, physician assistants and other health-care professionals who wish to add a new dimension to their understanding of an approach to health and disease. The main topics include: "Why Learn Traditional Chinese Medicine (TCM)? How Does It Differ From Western Medicine?", "How TCM Practitioners Diagnose And Treat Patients", "Basic Concepts Of TCM And Modern Research Findings", "TCM Differential Diagnosis And Treatment Principles", "Introduction To Chinese Physical And Mental Exercises: Tai-Chi And Qi-Gong", "Herbal Medicine And Acupuncture In The United States: An Overview Of The Regulation, Products And Patterns Of Use", "Introduction To Chinese Herbal Medicine/Dietetics", "Clinical Application And Pharmacological Basis Of Chinese Herbal Medicine"', "Introduction To Acupuncture And Other Forms Of Acupoint Stimulation", "Scientific Research And Modern Use Of Acupuncture". Also included are detailed discussions with hands-on demonstrations of modalities (common and important acupuncture points and herbs) that can be integrated with conventional Western medicine for symptom control and management of common conditions such as: women's health problems, myofascial pain syndrome, fibromyalgia, chronic degenerative diseases, vascular diseases, stress and others. For more information and a Registration Form, please call (310) 206-1876, fax (310) 206-0370, email at: epang@ucla.edu (Elaine Pang), or write to: UCLA Center for East-West Medicine, Suite 420, 200 Medical Plaza, Los Angeles, CA 90095. From owner-ageing@net.bio.net Wed Dec 06 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!torn!newshost.uwo.ca!usenet From: Charles Carter Newsgroups: bionet.molbio.ageing Subject: Re: DNA Date: 7 Dec 1995 03:13:34 GMT Organization: (UWO, London, Canada) Lines: 37 Message-ID: <4a5m4u$r45@falcon.ccs.uwo.ca> References: <49hpno$m3p@news.cuny.edu> NNTP-Posting-Host: ts11-9.slip.uwo.ca Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Authenticated: ccarter2@ts11-9.slip.uwo.ca X-Mailer: Mozilla 1.22 (Windows; I; 16bit) Etha Schlemermeyer wrote: >Can somebody hint me in the right >direction where to look: >I would like to read up on the >phenomen of DNA somethings (sorry >I forgot) that gets broken off every >time a cell replicates. So that the >"end" of that cells replication >ability is determined by these >appendages. Maybe someone knows >what I mean. > >Thanks, > > >Etha Hi Etha, I'm not sure if anyone responded to this yet but I know a bit about the subject so I'll reply anyway. Each time your chromosomes replicate, one of the strands of your chromosomes (they are double stranded) shortens a little bit (for reasons you may or may not want me to go into). An enzyme in the cell called Telomerase compensates for this loss by adding extra bases to the DNA in reproductive cells, but this phenomenon isn't found in somatic cells. Any biochemistry textbook should provide at least a few pages on the subjec, such as: Molecular and Cellular Biology: Stephen L. Wolfe. Wadsworth publishing company. 1993. Pages 971-975. - I hope this helps a little, and I hope that I don't find your question was already answered which would mean I'd have to figure out how to delete this! -Chuck From owner-ageing@net.bio.net Wed Dec 06 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!chi-news.cic.net!nntp.coast.net!torn!newshost.uwo.ca!usenet From: Charles Carter Newsgroups: bionet.molbio.ageing Subject: Re: Reduced caloric intake and lifespan Date: 7 Dec 1995 03:30:39 GMT Organization: (UWO, London, Canada) Lines: 12 Message-ID: <4a5n4v$r45@falcon.ccs.uwo.ca> References: <30C212CB.2A95@tribeca.ios.com> <49vgo0$lhi@maureen.teleport.com> NNTP-Posting-Host: ts11-9.slip.uwo.ca Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Authenticated: ccarter2@ts11-9.slip.uwo.ca X-Mailer: Mozilla 1.22 (Windows; I; 16bit) Hi Jo, I read somewhere (recently) that the anti-aging effects of Melatonin are primarily the result of its powerful free-radical scavenging abilities. Has anyone done an experiment which takes this seemingly confounding factor into consideration? Just wondering.. Chuck From owner-ageing@net.bio.net Wed Dec 06 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.chnt.gtegsc.com!news.kreonet.re.kr!news.dacom.co.kr!news.uoregon.edu!news.sprintlink.net!news.unicomp.net!usenet From: flaczko@conline.com (Frank L Laczko Sr.) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: DHEA Date: 7 Dec 1995 22:25:05 GMT Organization: Gemitaur Ltd Lines: 6 Message-ID: <4a7pk1$2qd@news.unicomp.net> Reply-To: flaczko@conline.com NNTP-Posting-Host: 204.96.7.123 Mime-Version: 1.0 X-Newsreader: WinVN 0.99.2 Xref: biosci bionet.molbio.ageing:2291 sci.life-extension:8976 Could anyone comment on why DHEA was taken off the open market by the FDA? I understand it used to be available freely. Frank L Laczko flaczko@conline.com From owner-ageing@net.bio.net Thu Dec 07 22:00:00 1995 Path: biosci!ns1.faseb.org!lamarck.sura.net!newsfeed.internetmci.com!psgrain!nntp.teleport.com!jor From: jor@teleport.com (Jo Robinson) Newsgroups: bionet.molbio.ageing Subject: Re: Reduced caloric intake and lifespan Date: 8 Dec 1995 17:08:16 GMT Organization: Teleport - Portland's Public Access (503) 220-1016 Lines: 52 Message-ID: <4a9re0$7rd@maureen.teleport.com> References: <30C212CB.2A95@tribeca.ios.com> <49vgo0$lhi@maureen.teleport.com> <4a5n4v$r45@falcon.ccs.uwo.ca> NNTP-Posting-Host: kelly.teleport.com X-Newsreader: TIN [version 1.2 PL2] Charles Carter (ccarter2@mustang.uwo.ca) wrote: : Hi Jo, : I read somewhere (recently) that the anti-aging effects of Melatonin : are primarily the result of its powerful free-radical scavenging : abilities. Has anyone done an experiment which takes this seemingly : confounding factor into consideration? : : Just wondering.. : : Chuck Chuck - I'm hoping you read about melatonin's free-radical scavenging, anti-aging properties in our book.... In our book, we mention six reasons why melatonin might extend life, beginning with the one we believe to be most influential: 1. Reducing free radical damage. 2. Stimulating an aging immune system 3. Protecting the cardiovascular system 4. Stabilizing the body's circadian rhythm 5. Restoring the nightly cycle of rest and repair by preserving slow wave sleep 6. Stimulating the production of growth hormone. I'm a bit confused as to why you call melatonin's "free-radical scavenging" ability a confounding factor. Free-radical scavenging" means eliminating free radicals. Currently, the free radical theory of aging has the most adherents. You might want to check out the following references: [ "Free Radical Theory of Aging" Mutation Research 1992; 275:257-66. And the book "Free Radicals and Aging" Boca Raton: CRC Press, 1993. Unfortunately, this book is expensive, around $100.] As for experiments which specifically address melatonin's free-radical scavenging prowess, Reiter has performed dozens of them, although not in the context of an anti-aging study. There are some interesting human studies, however, that show that older people produce more free radicals than younger ones. Furthermore, most degenerative disease are now believed to be linked in some manner with free radical damage. THe list of free radical-mediated conditions and diseases includes ulcers, diabetes, cancer, Parkinson's disease, Alzheimer's disease, stroke, coronary artery disease, atherosclerosis, scleroderma, arthritis, herpes zoster, cataracts, macular degeneration -- in short, if old people got it, free radicals are somehow involved. Jo -- +-----------------------------------+-----------------------------------------+ Jo Robinson jor@teleport.com Co-author, with Russel J. Reiter- MELATONIN: Your Body's Natural Wonder Drug For a melatonin FAQ, go to: http://www.teleport.com/~jor (Note: I have no financial connection with any melatonin supplier.) +-----------------------------------+-----------------------------------------+ From owner-ageing@net.bio.net Fri Dec 08 22:00:00 1995 Path: biosci!ST.CEU.EDU!AJackson From: AJackson@ST.CEU.EDU ("Alan E. Jackson") Newsgroups: bionet.molbio.ageing Subject: MAGNETIC HEALTH EFFECTS Date: 9 Dec 1995 14:04:40 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 195 Sender: daemon@net.bio.net Distribution: world Message-ID: <30CA0749@st.ceu.edu> NNTP-Posting-Host: net.bio.net Introducing "MAGNETRITION"; a term describing the process by which magnetism is utilized boilogically. Awaiting mankind's acceptance, the study of magnetrition offers man a healthier and longer life. This new knowledge concerning mans' magnetritional needs, when utilized, will represent a maturization milestone in the history of mankind. The assessment of research presents these facts; l. Magnetic bacteria use the properties of a magnetic field in order to form a chain of magnetite within its' body, from the iron it absorbs. 2. Magnetic bacteria use the properties of a magnetic field in order to migrate magneticly. 3. Magnetic bacteria live and die within the cells of our body. 4. Magnetic bacteria not having its' needs met, as it attempts its' functions within our cells, leads to the deterioration of body tissues. 5. Astronauts are now recognized as suffering from magnetic deficiency syndrome, brought about by the needs of magnetic bacteria, (within their cells), not being met while outside the earth's magnetic field. 6. A prolonged state of inactivity of magnetic bacteria within cells, such as when a bird's egg is not turned, or an infant is not carried, leads to energy levels too low to maintain life. 7. Periodic exposure to the magnetic field produced by A/C voltage causes poorly formed nuclear envelopes, within cells. 8. Through the proper use of magnetic fields, man may now achieve a higher degree of wellbeing, and travel farther through both time and space. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The following article is from; THE NEWS-TIMES, Morehead City-beaufort, N.C. Monday, Nov. 11, 1985. "LOCAL THEORIST BELIEVES MOVEMENT IS ESSENTIAL TO CELLULAR GROWTH, LIFE". BY JOHN HACKNEY, News-Times Staff Writer. ALAN JACKSON, Morehead City, fancies himself as a backyard philosopher. He spends a lot of hours reading books, magazines and research papers trying to understand just why certain things are the way they are. Mr. Jackson's most recent research has yielded an astounding theory; that movement is as important as nourishment to human beings. He came to that conclusion based on the behavior of magnetic bacteria. He also believes these bacteria may be responsible for cell division. "I think movement through the earth's magnetic field is as important as nutrition." MR. JACKSON, 32, left high school at the age of 17 to join the Marine Corp. He spent four years at Cherry Point, during which time he earned general education development (G.E.D.) degree and took college preparatory courses in various fields. Since leaving Cherry Point, he has held jobs with Hatsel Electric Co.; with Conner Homes as an electrician; with Carteret Court Apartments, as maintenance supervisor; and at Sea Coast Refrigeration. He has also taken several college courses at Carteret Technical College. MR. JACKSON believes the earth's magnetic field is generated by molten lava rotating in the earth's core. The lava moves in the opposite direction of the earth itself, thus creating such a field. "If we go to other planets, and no molten lava is flowing under the surface to create a magnetic field, the chances of finding life as we know it is slim." Without flux lines, the magnetic bacteria would have no guide to food. "we can't live without flux lines," he said. Based on his unguessable research, Mr. Jackson theorizes that magnetic bacteria in cells follow flux lines within the geomagnetic field to get iron, which is there source of nourishment. DR. RICHARD P. BLAKEMORE, a scientist at the University of New Hampshire, has said that amorphous cells (cells without form) accumulate a great deal of iron from outside cell walls to produce magnetic particles. Mr. Jackson believes it is more then a coincidence that humans need iron supplement to exist. SCIENTISTS know that bacteria collect and store iron, but they have yet to discover how. Mr. Jackson thinks magnetic bacteria swim inside individual cells within the body to get iron, possibly from the exterior walls of the cell nucleus or from the outer walls of the cell itself. He contends the bacteria move within the cell according to the body's orientation to magnetic flux lines. It has been shown that magnetic bacteria in the northern hemisphere migrate along flex lines in a northerly fashion, while magnetic bacteria in the southern hemisphere move south THE NUMBERS of north-seeking and south-seeking magnetic bacteria at the equator have been proven equal, indicating the effect of flux lines on bacteria. Dr. Blakemore and Dr. Richard B. Frankel of the Massachusetts Institute of Technology wrote that "magnetotactic bacteria are bottom-dwelling organisms that are either anaerobic (capable of living only in the absence of oxygen) or microaerophilic (surviving best in environments with little oxygen)." Therefore, they theorize, these bacteria would have a tendency to migrate downward, depending on their location, because "it would help them to avoid toxic effects of the greater concentration of oxygen in surface water." Mr. Jackson believes all people are essentially addicted to movement. An april 1979 article in Omni magazine cited the deterioration of astronauts' bones after periods of inactivity or weightlessness. THIS DETERIORATION of bones, called osteoporosis, is thought by most to be associated with lack of gravitational forces in space. Mr. Jackson thinks it is caused by the body having almost no orientation to the earth's magnetic field (or to north and south poles). Wiring within the spaceship may create some magnetism, but no definite poles, from which bacteria can orient themselves. WITHOUT bodily movement, magnetic bacteria cannot move in the cell along magnetic flux lines. Mr. Jackson said that was the reason chicken eggs, if not moved after being laid, would deteriorate. Without movement, the bacteria cannot constantly reorient themselves and move, and are left in a mass on one side of the cell. It is the movement of those bacteria that is important to cellular growth. He said cells were important to both tissues and bone growth in the body, thus accounting for the deterioration of bones found in astronauts. HE THINKS further experiments might show that astronauts have some deterioration of all tissues. Mr. Jackson said all people, young and old, are indirectly affected by magnetic bacteria. He thinks indians used to carry their papooses (babies) on their backs to keep them moving and thus indirectly helping the body grow. HE ALSO believes crib death of babies is caused from lack of movement. He said babies do not have the muscle coordination necessary to move themselves when first born. If the are not moved, the magnetic bacteria will be essentially immobile and not be able to set many body function in motion MR. JACKSON also believes lack of movement may be the reason bones and other tissues begin to fade as people get older and inactive. The less movement, the less the body will grow. He added that one experiment exemplified how magnetic bacteria could be degaussed (or rendered neutral in magnetism) through the application of heat. He has seized on this to theorize the reason for the basis of cellular life. MR. JACKSON believes that as human cells age , magnetic bacteria and other bacteria crowd the cells, creating excess friction or heat (thermal energy), which effectively demagnetizes magnetic bacteria for a moment, causing half the bacteria to lose their orientation to flux lines and head in the opposite direction. This intense action may cause cells to split. He believes that scientists may have overlooked the fact that magnetic bacteria heading in opposite directions may cause DNA (dioxyribo nucleic acid) molecules in the cell nucleus to split. DNA is associated with the transmission of genes in all living things. THE END. From owner-ageing@net.bio.net Sat Dec 09 22:00:00 1995 Path: biosci!news.alaska.edu!newsfeed.acns.nwu.edu!news.luc.edu!chi-news.cic.net!newsfeed.internetmci.com!in2.uu.net!news-feed.mci.newscorp.com!news.delphi.com!syama From: syama@delphi.com (Sunil Khemaney) Newsgroups: bionet.molbio.ageing Subject: Melanoma? Date: 10 Dec 1995 03:51:32 GMT Organization: Delphi Internet Services Corporation Lines: 66 Message-ID: <9512092127591.The_Win-D.syama@delphi.com> NNTP-Posting-Host: bos1e.delphi.com X-To: Sunil Khemaney I'm looking for some help for a friend who is presently overseas and in the boonies not near any dermatologist (or doctor for that matter). He's had a mole on his upper back for at least a couple of years (flesh and brownish colored in skin tone.) Approx. 4 weeks ago, it was noticed that it had gotten a little bit redder but nobody took it very seriously. About 3 weeks ago, it was noticably redder and was starting to get taller. At this time, it was still smooth in the sense that it was roundish on the top and not crusty and looked relatively uniform to the eye. Approx. 2 weeks ago, it started getting bigger and taller and rougher looking and little specks (one main one and several smaller ones) started appearing on the summit which appeared to the eye like tiny little freckles or blood points. Today, looking at it with a magnifying glass, the shape is irregular and it is warty-looking (little eruptions of skin coming out). The little freckles appear to be blood and there are six of them--some very small. They appear almost as if they're linked up to each other like a threadlike web. It is multicolored in the sense that it seems to have a slight grayishness to part of it. Closer to the back, it's reddish and inflamed around the edges down around the bottom of it. It's pinky, fleshy colored overall. The freckles are the color of dried blood. The present size is approx. 0.5 cm at its widest part and approx. 1.3 mm high. It is at least twice as high as it was 4 weeks ago and a little wider than it was. Some other factors which may be relevant here: he began having massage in the sun with oil about 4 weeks ago and he's had 3 massages. The type of massage is one that may have irritated it since it was right on the muscle massage line so it would have been rubbed quite vigorously in that area. The question that we have is since this is warty-looking, could it be a wart that started growing from a mole or could it have always been a smoother wart that has now begun to grow and explode because of irritation? Or could it be a mole that has always been a melanoma or a mole that is now becoming a melanoma? And if so, do melanomas usually grow this quickly in the sense of the changes they go through (i.e. the mole being there for a long time but major changes like this occuring so quickly in the last 3-4 weeks? There does not seem to be an indentation on the top of it. In a sense, it sort of looks like it could be a basil cell carcinoma, however, it's not smooth any more on the surface--it's more warty and rough and there's no one clear dimple in the middle. Rather, there doesn't seem to be any real concave in the top or middle of it. If it is a melanoma, do days matter? In other words, it may take 5 days to get a proper biopsy vs cutting it out himself in an improper way now and sending it for analysis. He has the necessary scalpel and Formalin preservative. Could irritation from massaging have created some type of melanoma change in it? Any help or advice would be much appreciated. From owner-ageing@net.bio.net Sun Dec 10 22:00:00 1995 Path: biosci!bcm.tmc.edu!pendragon!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!nntp.news.primenet.com!news.primenet.com!kg.com!keving From: keving@primenet.com (Kevin Goldstein) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: 10 Dec 1995 02:20:40 -0700 Organization: Primenet Lines: 21 Sender: root@primenet.com Distribution: world Message-ID: References: <4a1tff$m0t@odo.PEAK.ORG> X-Posted-By: kg.com X-Newsreader: Trumpet for Windows [Version 1.0 Rev B final beta #4] In article rcb1@LEX.LCCC.EDU (Ron Blue) writes: >From: rcb1@LEX.LCCC.EDU (Ron Blue) >Subject: Re: Melatonin-dose for anti-aging >Date: 6 Dec 1995 09:48:23 -0800 >On 5 Dec 1995, David Gore wrote: >> Why not weigh the water each evening and each morning? The difference would >> be how much water they drank (you may have to allow for some evaporation). >> Dave Gore >Mice probably get a lot of their water from their food, not by drinking >water. This would be a poor operational definition. >Maybe you should mix it in the food ( a few pellets) if they eat them >they get the rest of the food. Ron Blue We don't care how much water they drank *total*, only how much melatonin-laced water they drank, and that _would_ be determined by weighing the water before and after replacing it each day. Look back at what we are trying to do here. -Kevin Goldstein From owner-ageing@net.bio.net Sun Dec 10 22:00:00 1995 Path: biosci!bloom-beacon.mit.edu!newsfeed.internetmci.com!chi-news.cic.net!news.uiowa.edu!girl.physlog.uiowa.edu!user From: peterseg@physlog-po.physlog.uiowa.edu (Greg Petersen) Newsgroups: bionet.molbio.ageing Subject: Re: MAGNETIC HEALTH EFFECTS Date: 11 Dec 1995 20:09:44 GMT Organization: University of Iowa, Iowa City, IA, USA Lines: 9 Distribution: world Message-ID: References: <30CA0749@st.ceu.edu> NNTP-Posting-Host: girl.physlog.uiowa.edu Could someone explain in few words what these magnetic bacteria realy are? This is the firs time for me to hear that there is an organism that is able to utilize magnetic fields for movement (or is it just for orientation?). Also, how could these bacteria utilize iron as an energy souce? I would appriciate if someone explained these things briefly. Branimir G1 Mol Bio / U of I From owner-ageing@net.bio.net Sun Dec 10 22:00:00 1995 Path: biosci!LEX.LCCC.EDU!rcb1 From: rcb1@LEX.LCCC.EDU (Ron Blue) Newsgroups: bionet.molbio.ageing Subject: Re: MAGNETIC HEALTH EFFECTS Date: 11 Dec 1995 06:51:27 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 198 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <30CA0749@st.ceu.edu> NNTP-Posting-Host: net.bio.net On 9 Dec 1995, Alan E. Jackson wrote: >>>>>CUT>>> > l. Magnetic bacteria use the properties of a magnetic field in order > to form a chain of magnetite within its' body, from the iron it > absorbs. granted > > 2. Magnetic bacteria use the properties of a magnetic field in order > to migrate magneticly. maybe > 3. Magnetic bacteria live and die within the cells of our body. granted > 4. Magnetic bacteria not having its' needs met, as it attempts its' > functions within our cells, leads to the deterioration of body > tissues. maybe > 5. Astronauts are now recognized as suffering from magnetic deficiency > syndrome, brought about by the needs of magnetic bacteria, (within > their cells), not being met while outside the earth's magnetic field. The magnetic fields are stronger. So this is not true. > 6. A prolonged state of inactivity of magnetic bacteria within cells, > such as when a bird's egg is not turned, or an infant is not carried, > leads to energy levels too low to maintain life. Not true, but a low magnetic field may increase mutation rates. > 7. Periodic exposure to the magnetic field produced by A/C voltage > causes poorly formed nuclear envelopes, within cells. Interesting. Can you document your sources. > 8. Through the proper use of magnetic fields, man may now achieve a > higher degree of wellbeing, and travel farther through both time > and space. maybe, but I would prefer to have extra fuel. >>>>CUT>>> > Mr. Jackson's most recent research has yielded an astounding theory; > that movement is as important as nourishment to human beings. He came to > that conclusion based on the behavior of magnetic bacteria. maybe > > He also believes these bacteria may be responsible for cell division. maybe > "I think movement through the earth's magnetic field is as important as > nutrition." maybe >>>>>CUT>>> > MR. JACKSON believes the earth's magnetic field is generated by molten > lava rotating in the earth's core. The lava moves in the opposite > direction of the earth itself, thus creating such a field. Wrong. There is a very thin layer of superconduction material at the boundry of solid earth and liquid earth. This material is charged randomly due to piezoid electrical discharge caused by earth quakes. The discharge can create an electrical field lasting up to 9 million years. It can also be reversed every million years. > "If we go to other planets, and no molten lava is flowing under the > surface to create a magnetic field, the chances of finding life as we > know it is slim." True life dies out when the magnetic fields approach zero during a flip cycle, but it does not die out completely. So this statement is unwarrented. > Without flux lines, the magnetic bacteria would have no guide to food. > "we can't live without flux lines," he said. wrong. Magnetic field may be useful to "orient" but most movement is random. Bacteria can "learn" that it gets food on the dark side of a container. So stimulus-response would be a more useful idea than magnetism. > Based on his unguessable research, Mr. Jackson theorizes that magnetic > bacteria in cells follow flux lines within the geomagnetic field to get > iron, which is there source of nourishment. Iron, is related to cancer. > > DR. RICHARD P. BLAKEMORE, a scientist at the University of New > Hampshire, has said that amorphous cells (cells without form) accumulate > a great deal of iron from outside cell walls to produce magnetic > particles. > > Mr. Jackson believes it is more then a coincidence that humans need iron > supplement to exist. I predict if you placed a rat in a totally protected environment under high oxygen with NO IRON in its diet that it would live LONGER than other rats. > SCIENTISTS know that bacteria collect and store iron, but they have yet > to discover how. The same way the store gold on the outside of there bodies. This does support you idea. > Mr. Jackson thinks magnetic bacteria swim inside > individual cells within the body to get iron, possibly from the exterior > walls of the cell nucleus or from the outer walls of the cell itself. may be > He contends the bacteria move within the cell according to the body's > orientation to magnetic flux lines. Blood flow would likely be more important. > It has been shown that magnetic > bacteria in the northern hemisphere migrate along flex lines in a > northerly fashion, while magnetic bacteria in the southern hemisphere > move south. granted that bacteria will orient toward magnetic field and oscillating radio fields. The underlining reason could be the transport mechanisms in the microtubulines, which may be related to motor or nerve impulses. > > THE NUMBERS of north-seeking and south-seeking magnetic bacteria at > the equator have been proven equal, indicating the effect of flux lines > on bacteria. > > Dr. Blakemore and Dr. Richard B. Frankel of the Massachusetts Institute > of Technology wrote that "magnetotactic bacteria are bottom-dwelling > organisms that are either anaerobic (capable of living only in the absence > of oxygen) or microaerophilic (surviving best in environments with little > oxygen)." > > Therefore, they theorize, these bacteria would have a tendency to > migrate downward, depending on their location, because "it would help > them to avoid toxic effects of the greater concentration of oxygen in > surface water." > > Mr. Jackson believes all people are essentially addicted to movement. > An april 1979 article in Omni magazine cited the deterioration of > astronauts' bones after periods of inactivity or weightlessness. > > THIS DETERIORATION of bones, called osteoporosis, is thought by most > to be associated with lack of gravitational forces in space. > > Mr. Jackson thinks it is caused by the body having almost no > orientation to the earth's magnetic field (or to north and south poles). > Wiring within the spaceship may create some magnetism, but no definite > poles, from which bacteria can orient themselves. If you placed a rat on the space station and rotated in a box for 30 days the bones would not deteriorate due to lack of gravity or magnetism. They would be normal if you feed them. > WITHOUT bodily movement, magnetic bacteria cannot move in the cell > along magnetic flux lines. not true > Mr. Jackson said that was the reason chicken > eggs, if not moved after being laid, would deteriorate. Without > movement, the bacteria (I assume you mean transport cells with a magnetic affinity) > cannot constantly reorient themselves and move, > and are left in a mass on one side of the cell. > > It is the movement of those bacteria that is important to cellular > growth. This could be easy to check out experimentally. If the results do not support your idea what would you do next? Give up your idea? > He said cells were important to both tissues and bone growth > in the body, thus accounting for the deterioration of bones found in > astronauts. > > HE THINKS further experiments might show that astronauts have some > deterioration of all tissues. True, but due to the reason you have suggested. The radiation is so intense that astronauts have trouble sleeping from the FLASHES in their eyes from cosmic rays. > Mr. Jackson said all people, young and old, are indirectly affected > by magnetic bacteria. He thinks indians used to carry their papooses > (babies) on their backs to keep them moving and thus indirectly helping > the body grow. Granted that movement of babies increases their growth rate, but necessarily due to magnetic field modulation. > HE ALSO believes crib death of babies is caused from lack of movement. Since SIDS is multiple caused by different factors, you magnetic no movement may be one out of a thousand cases. > He said babies do not have the muscle coordination necessary to move > themselves when first born. If the are not moved, the magnetic bacteria > will be essentially immobile and not be able to set many body function in > motion > > MR. JACKSON also believes lack of movement may be the reason bones > and other tissues begin to fade as people get older and inactive. The > less movement, the less the body will grow. I have a very low movement level, I beleive it only caused me to get fat. > He added that one experiment exemplified how magnetic bacteria could be > degaussed (or rendered neutral in magnetism) through the application of > heat. He has seized on this to theorize the reason for the basis of > cellular life. heat? Heat may be criticial to control ossillations in the microtubulines. > MR. JACKSON believes that as human cells age , magnetic bacteria and > other bacteria crowd the cells, creating excess friction or heat (thermal > energy), which effectively demagnetizes magnetic bacteria for a moment, > causing half the bacteria to lose their orientation to flux lines and > head in the opposite direction. This intense action may cause cells to > split. maybe > > He believes that scientists may have overlooked the fact that magnetic > bacteria heading in opposite directions may cause DNA (dioxyribo nucleic > acid) molecules in the cell nucleus to split. DNA is associated with > the transmission of genes in all living things. THE END. We over look alot. True that magnetic field may be used by the DNA to help cell division, but it does not necessarily support the strength of the model you are suggestion. With revision, careful documentation, and "suggestion" that magnetic field "may" have some of the effects you suggested would go a long way to have people listen to your ideas. Granted that they are NOT totally without merit, but you must remember at people "orient" themselves to ideas and experimental information. If you do not present you model in the politically correct way it is likely that you will never live long enough to find general acceptance of you model during your life even if you are totally correct. Check out the concept of parsimony and zeitgeist. Ron Blue From owner-ageing@net.bio.net Sun Dec 10 22:00:00 1995 Path: biosci!IINET.NET.AU!roberth From: roberth@IINET.NET.AU (Robert Horley) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin-dose for anti-aging Date: 11 Dec 1995 05:56:10 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 25 Sender: daemon@net.bio.net Distribution: world Message-ID: <199512111353.VAA21957@grunge.iinet.net.au> NNTP-Posting-Host: net.bio.net At 02:20 12/10/95 -0700, Kevin Goldstein wrote: > >We don't care how much water they drank *total*, only how much melatonin-laced >water they drank, and that _would_ be determined by weighing the water before >and after replacing it each day. Look back at what we are trying to do here. > >-Kevin Goldstein > Kevin has been asking a very simple question, which can be answered easily within the framework of the present experiment. Do I sense a little obfuscation and a deliberate effort not to answer the question? Could this be due to the fact that the one time I saw the actual doses given in mouse experiments written up, they were much much larger per unit of body weight than the amounts that the authors of pro-melatonin books tell people to take. Could it be that they don't want to set themselves up for a court case if people take the actual mouse doses and there are unwanted side effects, and also don't want their readers to know that the tiny amounts they recommend probably wont work very well for life extension purposes. If the experts wont come clean, then I'll go through my old records and try to find the actual doses. Robert Horley From owner-ageing@net.bio.net Sun Dec 10 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!chi-news.cic.net!news.uiowa.edu!girl.physlog.uiowa.edu!user From: peterseg@physlog-po.physlog.uiowa.edu (Greg Petersen) Newsgroups: bionet.molbio.ageing Subject: Re: Melanoma? Date: 11 Dec 1995 20:18:42 GMT Organization: University of Iowa, Iowa City, IA, USA Lines: 13 Distribution: world Message-ID: References: <9512092127591.The_Win-D.syama@delphi.com> NNTP-Posting-Host: girl.physlog.uiowa.edu I might not be the right person to say this, but I had two years of medical training, and I'm now a graduate student in molecular biology. It looks like your friend might have a melanoma on his neck. I would NOT suggest that he takes care of this himself since there is a possibility of doing more damage. I don't understand one thing, however. How come that he can have a biopsy, and there is no dermatologist or family practice doctor, or like, that can examine him? I'll just tell you one thing: when in doubt, think of the worst. Believing that "it is nothing" will not help. Rush to the nearest medical facility as soon as possible, even if that means traveling for 5 days. Branimir From owner-ageing@net.bio.net Mon Dec 11 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in1.uu.net!csn!nntp-xfer-2.csn.net!yuma!purdue!haven.umd.edu!cville-srv.wam.umd.edu!theoblit From: theoblit@wam.umd.edu (Jason Taylor) Newsgroups: bionet.molbio.ageing Subject: Re: Nitrogen balance...how can we measure this? Date: 11 Dec 1995 21:02:11 GMT Organization: University of Maryland College Park Lines: 27 Distribution: world Message-ID: <4ai68j$mt2@cville-srv.wam.umd.edu> NNTP-Posting-Host: rac2.wam.umd.edu X-Newsreader: TIN [version 1.2 PL0] References: -( + 4 grams) nitrogen intake ~= protein intake/6.25 <>=integrated over 24 hours. (Must save all urine.) urine urea nitrogen=urea concentration*volume : 2. Anyone know the clinical symptoms of loss of nitrogen balance? Loss of? You might mean imbalance. Negative --> catabolism. Positive --> growth. Ideally it is +4 - +6 if you are healing. Negative nitrogen balance also occurs if you're diet has bad amino acid ratios. I'd think you'd have a craving for, say, milk if it was negative. Hope this helps some. Cheers, Jason ______________________________________________________________________________ Jason Taylor, Greenbelt, MD USA|"Doctor, don't cut so deep! That's the third http://www.wam.umd.edu/~theoblit| operating table you've ruined this week!" From owner-ageing@net.bio.net Mon Dec 11 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in1.uu.net!csn!nntp-xfer-2.csn.net!yuma!purdue!haven.umd.edu!cville-srv.wam.umd.edu!theoblit From: theoblit@wam.umd.edu (Jason Taylor) Newsgroups: bionet.molbio.ageing Subject: Re: Melanoma? Date: 11 Dec 1995 21:23:16 GMT Organization: University of Maryland College Park Lines: 30 Distribution: world Message-ID: <4ai7g4$mt2@cville-srv.wam.umd.edu> NNTP-Posting-Host: rac2.wam.umd.edu X-Newsreader: TIN [version 1.2 PL0] References: <9512092127591.The_Win-D.syama@delphi. Sunil Khemaney (syama@delphi.com) wrote: : Or could it be a mole that has always been a melanoma or a mole : that is now becoming a melanoma? And if so, do melanomas usually As far I recall, these are all classic symptoms of skin melanoma. : If it is a melanoma, do days matter? In other words, it may take I don't know, but either you or your friend needs to see a specialist immediately. : 5 days to get a proper biopsy vs cutting it out himself in an : improper way now and sending it for analysis. He has the : necessary scalpel and Formalin preservative. : Could irritation from massaging have created some type of : melanoma change in it? Skin cancer is generally due to solar irradiation. But rancid oil is not good either. A melanoma's growth is limited by its blood supply, so massaging massaging could also have been bad. : Any help or advice would be much appreciated. Can't wait for the cardiac patients to hit the 'net. ______________________________________________________________________________ Jason Taylor, Greenbelt, MD USA|"Doctor, don't cut so deep! That's the third http://www.wam.umd.edu/~theoblit| operating table you've ruined this week!" From owner-ageing@net.bio.net Mon Dec 11 22:00:00 1995 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Re: hypotesis on ageing Date: 12 Dec 1995 12:58:53 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 17 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <4afkt3$2jla@venere.inet.it> NNTP-Posting-Host: net.bio.net Longevity list has ongoing dialogue on causes of aging. You can request copies of previous commentary thru the listserver.....Don On 10 Dec 1995, valentino wrote: > I belive that ageing is caused by viruses consedered harmless. > I'm trying to compose an hypotesis substaining that it's caused by > viruses. > Any information could be useful, so if you've got material about that, > please post me it...Even if it's aganist my hypotesis. > send it to Valentino@peg.it > > ...please do not send simple comments! > > > From owner-ageing@net.bio.net Mon Dec 11 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!EU.net!Norway.EU.net!nntp-oslo.UNINETT.no!nntp-trd.UNINETT.no!nac.no!ifi.uio.no!news.sics.se!newsfeed.sunet.se!news01.sunet.se!sunic!news99.sunet.se!newsfeed.tip.net!peroni.ita.tip.net!venere.inet.it!usenet From: valentino@peg.it (valentino) Newsgroups: bionet.molbio.ageing Subject: hypotesis on ageing Date: 10 Dec 1995 21:53:39 GMT Organization: pegaso Lines: 9 Message-ID: <4afkt3$2jla@venere.inet.it> NNTP-Posting-Host: 194.20.207.102 Mime-Version: 1.0 Content-Type: Text/Plain; charset=ISO-8859-1 X-Newsreader: WinVN 0.99.5 I belive that ageing is caused by viruses consedered harmless. I'm trying to compose an hypotesis substaining that it's caused by viruses. Any information could be useful, so if you've got material about that, please post me it...Even if it's aganist my hypotesis. send it to Valentino@peg.it ...please do not send simple comments! From owner-ageing@net.bio.net Mon Dec 11 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.sprintlink.net!ns1.win.net!dax!delano Newsgroups: bionet.molbio.ageing,sci.life-extension Message-ID: <208@dax.win.net> References: <4a7pk1$2qd@news.unicomp.net> Reply-To: delano@dax.win.net (David Blanco) From: delano@dax.win.net (David Blanco) Date: Tue, 12 Dec 1995 04:54:07 GMT Subject: Re: DHEA Lines: 36 Xref: biosci bionet.molbio.ageing:2303 sci.life-extension:9065 In 1984 the FDA, using certain arbitrary powers, deemed that DHEA was a drug. They then had the responsibility to go before the Dept. of Health and Human Services (HHS) within 60 days and show cause. They granted themselves an extension instead. DHEA was then kept off the market for the next ten years by continuous extensions. In 1994 Orin Hatch offered up a bill which eventually passed, albiet watered down, as the Dietary Supplement Health and Education Act. This was signed into law by Clinton in Oct. 1994. It striped the FDA of their arbitrary powers. The FDA must hold an open hearing with HHS and after showing cause and getting permission can remove a dietary supplement off the market. This in effect made DHEA available again as a nutritional supplement.. I have been offering DHEA (dehydroepiandrosterone) for some time now. Our DHEA is NOT an extract from the wild (Mexican, Peruvian or African) yam. It is NOT the herbal extract called Dioscorea. It does NOT contain the various plant-based sterols which supposedly can be metabolized into pregnenolone and other steroids. Regards, David In article <4a7pk1$2qd@news.unicomp.net>, Frank L Laczko Sr. (flaczko@conline.com) writes: >Could anyone comment on why DHEA was taken off the open market by the >FDA? I understand it used to be available freely. > >Frank L Laczko >flaczko@conline.com > > From owner-ageing@net.bio.net Tue Dec 12 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!sunrise.gv.ssi1.com!oronet!news From: Richard Tanner Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: DHEA Date: 13 Dec 1995 00:11:56 GMT Organization: "oronet, Penn Valley, CA" Lines: 4 Message-ID: <4al5oc$mqe@hg.oro.net> References: <4a7pk1$2qd@news.unicomp.net> NNTP-Posting-Host: tanrich.oro.net Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; 68K) X-URL: news:4a7pk1$2qd@news.unicomp.net Xref: biosci bionet.molbio.ageing:2306 sci.life-extension:9087 DHEA is available by mail order in the USA without any problems? It has not been taken off the market!! From owner-ageing@net.bio.net Tue Dec 12 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!swrinde!newsfeed.internetmci.com!btnet!demon!mail2news.demon.co.uk!longevb.demon.co.uk From: John de Rivaz Newsgroups: bionet.molbio.ageing Subject: Re: hypotesis on ageing Date: Wed, 13 Dec 1995 14:37:22 GMT Organization: Myorganisation Lines: 35 Message-ID: <95409072wnr@longevb.demon.co.uk> References: <4afkt3$2jla@venere.inet.it> Reply-To: John@longevb.demon.co.uk X-NNTP-Posting-Host: longevb.demon.co.uk X-Broken-Date: Wednesday, Dec 13, 1995 14.37.22 X-Newsreader: Newswin Alpha 0.7 X-SMTP-Posting-Host: longevb.demon.co.uk [Wed, 13 Dec 95 15:41:56 GMT] X-SMTP-Posting-Host: post.demon.co.uk [Wed, 13 Dec 95 15:42:38 GMT] I am also interested in this possibility. In fact I take it further. Could some of the diseases associated with ageing be the after effects of apparently self limiting viral attacks throughout life? For example, maybe that attack of viral enteritis could lead to stomach or bowel cancer twenty or thirty years later. Maybe it only works if you have the right genes, so everyone who gets that strain of enteritis doesn't also get stomach cancer. Possibly those who smoke their lungs will only get cancer if they are also given certain cold or influenza infections. In article: <4afkt3$2jla@venere.inet.it> valentino@peg.it (valentino) writes: > > I belive that ageing is caused by viruses consedered harmless. > I'm trying to compose an hypotesis substaining that it's caused by > viruses. > Any information could be useful, so if you've got material about that, > please post me it...Even if it's aganist my hypotesis. > send it to Valentino@peg.it > > ...please do not send simple comments! > > > -- Sincerely, **************************************** * Publisher of Longevity Report * John de Rivaz * Fractal Report * * details on request * **************************************** **** What is the point of life if it ends in death? **** From owner-ageing@net.bio.net Tue Dec 12 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!elroy.jpl.nasa.gov!swrinde!howland.reston.ans.net!ix.netcom.com!netnews From: harlan2@ix.netcom.com (Harlan Hoffman ) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: DHEA Date: 13 Dec 1995 03:47:50 GMT Organization: Netcom Lines: 28 Message-ID: <4alid6$i3v@ixnews6.ix.netcom.com> References: <4a7pk1$2qd@news.unicomp.net> <208@dax.win.net> NNTP-Posting-Host: ix-sf10-26.ix.netcom.com X-NETCOM-Date: Tue Dec 12 7:47:50 PM PST 1995 Xref: biosci bionet.molbio.ageing:2308 sci.life-extension:9091 In <208@dax.win.net> delano@dax.win.net (David Blanco) writes: >Our DHEA is NOT an extract from the wild (Mexican, Peruvian or >African) yam. It is NOT the herbal extract called Dioscorea. It >does NOT contain the various plant-based sterols which supposedly >can be metabolized into pregnenolone and other steroids. > >Regards, >David > > > > > >> >> > David: Then what is it from? I have been recieving mine from a pharmacia, in TX. It is a very powerful tool....They told me that theirs was a hormone derived product, (I obtained a rx for it from my MD). Any info would be appreciated. -- 'any road will lead to enlightenment, and enlightenment is then; embracing all roads.' From owner-ageing@net.bio.net Tue Dec 12 22:00:00 1995 Path: biosci!ST.CEU.EDU!AJackson From: AJackson@ST.CEU.EDU ("Alan E. Jackson") Newsgroups: bionet.molbio.ageing Subject: MAGNETIC HEALTH EFFECTS Date: 12 Dec 1995 18:16:38 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 155 Sender: daemon@net.bio.net Distribution: world Message-ID: <30CE36AC@st.ceu.edu> NNTP-Posting-Host: net.bio.net ----- The following addresses had delivery problems ----- (unrecoverable error) Branimir, I'm in the process of getting NASA to create a artificial magnetic field which will prevent the deterioration that now occurs in the astronauts, while in space. This deterioration, known as osteoporosis, will also be prevented within people here on earth, with the type/model of artificial magnetic field produced by NASA. For people to become aware that man has not, up until now, been useing magnetic fields to their full potential, will cause them to maintain much better health then ever before. And stop many from thinking problems are caused by things that are not causing them. After you read the info I sent to you, if the topic comes up in talking to someone, you will be able to make a statement that will be of great help to those around you. You will show the effects of an educated person. The magnetic bed will create a magnetic field around a person, (one like the earths), and the field will be made to shift every so often, (it seems about every 45 min or so), this will be like the bird caring for its egg. Electromagnetic fields, are something that our bodies have learned to use. Our bodies have learned to use the earth's type of a magnetic field. A/C voltage produces a magnetic field that shifts, or reverses, 60 times a second, and this makes it hard, or impossible, for magnetic bacteria, (in our cells), to make magnetite from the iron that we take into our bodies when we eat. The earth's magnetic field has its north and south poles stay in about the same place. These bacteria use the lines of flux when putting iron particals together, like a brick layer uses a string, to line up the bricks. When most of the iron particals, are lined up with their norths in the same direction, we call it magnetite, not just iron. The bacteria are doing this inside the cells, such as producing an electrical charge as they move about, (like we do crossing the carpet and then touching the TV), they cause the cell to divide when their population reaches a certain number, and they produce magnetite which is used to form the nuclear envelope, ( protecting the DNA). These bacteria serve these functions within our cells only when we provide them with what they need, like keeping fish healthy in a fish tank. Electromagnetic flux is like water, pretty much always the same, But it can be stronger or weaker. What I've learned is that our health is effected by how much we move around it a magnetic field. What I offer is what I perceive to be knowledge. Knowledge that can prevent crib death just by the mother realizing why she must carry her baby around with her. Like they use to do. Every person can now use this knowledge in their own life. Nothing to buy, but something they must do, learn something new. At your service, ____________________________________Alan_E._Jackson___________________________ REPLY FROM: Alan E. Jackson Return-Path: To: ageing@net.bio.net From: peterseg@physlog-po.physlog.uiowa.edu (Greg Petersen) Subject: Re: MAGNETIC HEALTH EFFECTS Date: 11 Dec 1995 20:09:44 GMT Message-ID: NNTP-Posting-Host: girl.physlog.uiowa.edu Could someone explain in few words what these magnetic bacteria realy are? This is the firs time for me to hear that there is an organism that is able to utilize magnetic fields for movement (or is it just for orientation?). Also, how could these bacteria utilize iron as an energy souce? I would appriciate if someone explained these things briefly. Branimir G1 Mol Bio / U of I ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ BETTER LATE, THEN NEVER. or REAL "HOME IMPROVEMENT". Tommas Edison is remembered as having warned us, and I believe he is quoted as having said, "You would be a fool to use A/C voltage rather then D/C voltage. But his nation did not heed his words of wisdom. If tommas Edison, the man who seems to have "opened the door" to the uses of electric current, was a child of God, (which is now evident from his effect on mankind), then at that time this nation turned from God, and began to lead others away, through its example. The many blessing that are afforded mankind, through the use of electricity, shows that the hand of God was guiding Edison, and mankind through him, into the "Age of Electricity" The warning given to others, concerning the use of A/C voltage, was given by the one who may have had the best understanding of electricity. This would be evident from the way he used such knowledge throughRout his life. Now today, information being gathered from studies, indicates that the use of A/C voltage may have been a wrong move for mankind. And obvious to anyone with a basic understanding of electricity, is the fact that the magnetic field produced by A/C voltage is more in contrast with the earth's field then D/C. More like the earth's, the magnetic field produced by D/C voltage is constant. But this may not be worth noting, unless there are life forms known to use the earth's magnetic field, such as magnetic bacteria. The small magnetic particles found withRin bacteria are noted as causing it to be effected by magnetic fields. These particles being found in man, should be viewed in that same light. The effect of bringing this issue to the forefront, as a "news topic", and having it held there long enough to educate people to the fact that they are being effected, healthRwise, by magnetic fields would be deemed necessary by anyone who becomes aware of these facts, and has the best interests of everyone in mind. --VAA00785.818741544/ns.utah.edu-- From owner-ageing@net.bio.net Thu Dec 14 22:00:00 1995 Path: biosci!NPD.UFSC.BR!bqa1kck From: bqa1kck@NPD.UFSC.BR (Karina Ckless) Newsgroups: bionet.molbio.ageing Subject: Apomorphine: pro-and/or antioxidant Date: 15 Dec 1995 03:55:49 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 19 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Hello, I am looking for information about pro- and/or antioxidant properties of apomorphine. This drug has been used in the treatment of Parkinson's disease. Can anyone help me? Thanks a lot... Karina ################################# KARINA CKLESS CP 476 Depto de Bioquimica - CCB - UFSC Florianopolis, SC 88040-900 Tel 55-48-2319692 Fax 55-48-2319672 e-mail bqa1kck@npd.ufsc.br ################################# From owner-ageing@net.bio.net Thu Dec 14 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!news.ecn.bgu.edu!movietone.ils.nwu.edu!newsfeed.acns.nwu.edu!news.cc.uic.edu!uicvm.uic.edu!u56375 Organization: University of Illinois at Chicago, ADN Computer Center Date: Fri, 15 Dec 1995 12:29:14 CST From: Message-ID: <95349.122914U56375@uicvm.uic.edu> Newsgroups: bionet.molbio.ageing Subject: POST-DOCTORAL RESEARCH ASSOCIATESHIP Lines: 13 The following position is available immediately for a study on human immunose nescence, Qualified individuals should write to Dr. Krishnaraj, University of I llinois at Chicago, Department of Medicine (M/C 787), 840 South Wood St, Chicag o, IL. 60612. FAX 312-413-2693 POST-DOCTORAL RESEARCH ASSOCIATESHIP available for a PhD or equivalent with exp erience in molecular biology and immunology to study human NK cells (NIH-funded ). Please send CV, salary requirements, reprints and three reference letters. Also, funding is likely to be avialable for a part-time or full-time RESEARCH S PECIALIST. Prefer biology graduates with work expereicnce in two or more of the following: Immunology, flowcytometry, ELISA, and molecular biology techniques. Please Send CV, salary requirements and three references. From owner-ageing@net.bio.net Thu Dec 14 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!uwm.edu!newsspool.doit.wisc.edu!news.doit.wisc.edu!F180-081.net.wisc.edu!harasha From: harasha@facstaff.wisc.edu (Brian) Newsgroups: bionet.molbio.ageing Subject: Cellular Senescence Date: Fri, 15 Dec 1995 10:21:30 Organization: UW-Madison Lines: 13 Message-ID: NNTP-Posting-Host: f180-081.net.wisc.edu Summary: Grad school X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] Can anyone direct me to some good investigators that work on cellular senescence and/or regeneration. I would like to apply to graduate school and have an advisor that might sponsor me and support my appplication. I contacted Dr. Judith Campisi at Berkeley, but she is in the biochemistry department there and I don't really have the backround to get accepted into that kind of department. I think I may be able to get into a developmental, pharmacological, or zoology dept. Joe Yracheta UW- Madison From owner-ageing@net.bio.net Thu Dec 14 22:00:00 1995 Path: biosci!daresbury!not-for-mail From: plinehan@hgmp.mrc.ac.uk (Mr. P.F. Linehan) Newsgroups: bionet.molbio.ageing Subject: Test Date: 15 Dec 1995 15:32:41 -0000 Lines: 3 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <4as4ep$hhs@mserv1.dl.ac.uk> content-length: 21 Original-To: ageing@dl.ac.uk This is a test.... From owner-ageing@net.bio.net Sun Dec 17 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!news.unicomp.net!usenet From: flaczko@conline.com (Frank L Laczko Sr.) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Lifelink Date: 18 Dec 1995 01:12:08 GMT Organization: Gemitaur Ltd Lines: 7 Message-ID: <4b2f58$p7u@news.unicomp.net> Reply-To: flaczko@conline.com NNTP-Posting-Host: 204.96.7.121 Mime-Version: 1.0 X-Newsreader: WinVN 0.99.2 Xref: biosci bionet.molbio.ageing:2314 sci.life-extension:9203 There were several references to Lifelink as a source for DHEA. Could someone Post or E-mail me their address/phone number please. Thanks Frank L Laczko Sr flaczko@conline.com From owner-ageing@net.bio.net Sun Dec 17 22:00:00 1995 Path: biosci!JEEVES.UCSD.EDU!hoschek From: hoschek@JEEVES.UCSD.EDU (Gisela Hoschek) Newsgroups: bionet.molbio.ageing Subject: Melatonin experiences Date: 18 Dec 1995 12:12:44 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 18 Sender: daemon@net.bio.net Distribution: world Message-ID: <199512182010.MAA28692@jeeves.ucsd.edu> NNTP-Posting-Host: net.bio.net My first experience I took 3mg which had a vitamin B-6 supplement. After waking up the next morning, I experienced the light headedness I associate with jet lag, but nothing as serious as prolonged nausea, which I would associated with serious drug side effects. What first time experiences do any of you have out there? How did you adjust the dosage, or did you stop taking the hormone? Tony I couldn't fall asleep after taking 2.5 mg + B-6, and when I finally did I suffered bad dreams. I lowered the dose to 1/8 (now about 0.3 mgs + B-6). I don't feel any effect, also not any inducement of sleep. Gisela From owner-ageing@net.bio.net Sun Dec 17 22:00:00 1995 Path: biosci!agate!newsxfer.itd.umich.edu!chi-news.cic.net!nntp.coast.net!news.sprintlink.net!news.cuny.edu!news From: Etha Schlemermeyer Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin experiences Date: 18 Dec 1995 14:19:55 GMT Organization: City University of New York/University Computer Center Lines: 19 Message-ID: <4b3tab$4i5@news.cuny.edu> References: <4b38ee$ftm@cloner2.ix.netcom.com> NNTP-Posting-Host: bio24.hunter.cuny.edu tony111@ix.netcom.com(Who Dat?) wrote: > > > My first experience I took 3mg which had a vitamin B-6 supplement. > After waking up the next morning, I experienced the light headedness I > associate with jet lag, but nothing as serious as prolonged nausea, > which I would associated with serious drug side effects. What first > time experiences do any of you have out there? How did you adjust the > dosage, or did you stop taking the hormone? > > Tony I just would not take the mixture with B-6. If you "try" anything new why mix it with something else that could have its own effect or a combined effect that you might not want. Everbody I know that took the B vitamin mixture made bad experiences and blamed melatonin for it. Took then only melatonin and felt great. Etha From owner-ageing@net.bio.net Sun Dec 17 22:00:00 1995 Path: biosci!agate!news.duke.edu!godot.cc.duq.edu!newsfeed.pitt.edu!uunet!in1.uu.net!newsfeed.internetmci.com!howland.reston.ans.net!ix.netcom.com!netnews From: tony111@ix.netcom.com(Who Dat?) Newsgroups: bionet.molbio.ageing Subject: Melatonin experiences Date: 18 Dec 1995 08:23:42 GMT Organization: Netcom Lines: 9 Message-ID: <4b38ee$ftm@cloner2.ix.netcom.com> NNTP-Posting-Host: ix-sf11-13.ix.netcom.com My first experience I took 3mg which had a vitamin B-6 supplement. After waking up the next morning, I experienced the light headedness I associate with jet lag, but nothing as serious as prolonged nausea, which I would associated with serious drug side effects. What first time experiences do any of you have out there? How did you adjust the dosage, or did you stop taking the hormone? Tony From owner-ageing@net.bio.net Mon Dec 18 22:00:00 1995 Path: biosci!agate!spool.mu.edu!howland.reston.ans.net!nntp.coast.net!news.sprintlink.net!dca.net!news From: thomass@dca.net (Rockit) Newsgroups: bionet.molbio.ageing Subject: Re: Melatonin experiences Date: 19 Dec 1995 02:34:09 GMT Organization: DCANet - Delaware Common Access Network Lines: 16 Message-ID: <4b58b2$hvr@dca.net> References: <4b38ee$ftm@cloner2.ix.netcom.com> NNTP-Posting-Host: ppp-1029.dca.net X-Newsreader: WinVN 0.92.6+ In article <4b38ee$ftm@cloner2.ix.netcom.com>, tony111@ix.netcom.com(Who Dat?) says: > > > My first experience I took 3mg which had a vitamin B-6 supplement. >After waking up the next morning, I experienced the light headedness I >associate with jet lag, but nothing as serious as prolonged nausea, >which I would associated with serious drug side effects. What first >time experiences do any of you have out there? How did you adjust the >dosage, or did you stop taking the hormone? > > Tony I switched to a preparation that did NOT include B-6, and slept much better, without the vivid dream effect of the B6. I also break the 3mg tablets into quarters, that seems to be a better dosage. From owner-ageing@net.bio.net Mon Dec 18 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!nntp.coast.net!news.net99.net!newshost.cyberramp.net!ramp3-25.cyberramp.net!user From: rwstudio@cyberramp.net (Ron Williams) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: Lifelink Date: 19 Dec 1995 04:34:24 GMT Organization: Ron Williams Studio Lines: 14 Message-ID: References: <4b2f58$p7u@news.unicomp.net> NNTP-Posting-Host: ramp3-25.cyberramp.net Xref: biosci bionet.molbio.ageing:2320 sci.life-extension:9233 In article <4b2f58$p7u@news.unicomp.net>, flaczko@conline.com wrote: > There were several references to Lifelink as a source for DHEA. Could > someone Post or E-mail me their address/phone number please. > > Thanks > Frank L Laczko Sr > flaczko@conline.com LifeLink 445 Liverly Lane Arroyo Grande, CA 93420 RW From owner-ageing@net.bio.net Mon Dec 18 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!newsfeed.internetmci.com!in1.uu.net!nntp.news.primenet.com!ip010.phx.primenet.com!user From: cmmc@primenet.com (Tapehead) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: DHEA Date: 16 Dec 1995 16:21:59 -0700 Organization: Tapeland Lines: 30 Sender: root@primenet.com Message-ID: References: <4a7pk1$2qd@news.unicomp.net> <208@dax.win.net> <4alid6$i3v@ixnews6.ix.netcom.com> X-Posted-By: ip16-056.phx.primenet.com Xref: biosci bionet.molbio.ageing:2321 sci.life-extension:9241 In article <4alid6$i3v@ixnews6.ix.netcom.com>, harlan2@ix.netcom.com (Harlan Hoffman ) wrote: > In <208@dax.win.net> delano@dax.win.net (David Blanco) writes: > > >Our DHEA is NOT an extract from the wild (Mexican, Peruvian or > >African) yam. It is NOT the herbal extract called Dioscorea. It > >does NOT contain the various plant-based sterols which supposedly > >can be metabolized into pregnenolone and other steroids. > > > >Regards, > >David > David: > Then what is it from? I have been recieving mine from a pharmacia, in > TX. It is a very powerful tool....They told me that theirs was a > hormone derived product, (I obtained a rx for it from my MD). Any > info would be appreciated. > -- > 'any road will lead to enlightenment, > and enlightenment is then; embracing all roads.' So, my question is: what does it do for you and how do you feel since you've been on it? Please respond to this post via -mail Thanks cmmc@primenet.com From owner-ageing@net.bio.net Tue Dec 19 22:00:00 1995 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Call your congress -- for free? (fwd) Date: 20 Dec 1995 03:31:17 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 49 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net (800# below, mandatory reading first,) What congressmen support life extension research and longevity studies? Would senator or representative even discuss the possibility of stopping the aging process using future biotechnological advancements? Or is it too radical for any politician to get near? More specifically, are there any legislators who might sponsor a bill favoring significant funds for research if the issue was thoroughly researched for him and the bill already written for him to proof and modify? That way the congressman doesn't have to exert himself too much to do the background work and legwork, but would get the credit for it if it flies. Would the congressman be motivated to take some action if he thought a large group of voters would remember him on election day? If so, what groups of people would he like to hear about? How many voters belong to LEF or Cryonics groups? Does AARP even support such ideas? What about life insurance groups? Or health and fitness associations, or retail merchants associations who would have more customers if more people stayed alive? Count out the morticians. The state legislators, too, have significant influence on how fed funds are distributed statewide as well as on state generated funds. Grant writers can be enlisted with the expectation of possible remuneration and professional acclaim. Don From: Rob Hardy Subject: Call your congress -- for free? A friend sent me this, and I am snowed in so I can't get to a pay phone to try it. Good luck! ---Rob > Call your congresspeople free, send the bill to the Christian Coalition. > "We tried it. It works." -CoE > > Ho ho ho...lets thank the Christian Coaltion for this one... > > The Christian Coalition, bless its soul, has set up 800 numbers to call the > U.S. Congress. These numbers patch directly through to the Capitol > switchboard. > > The numbers to use are 800/962-3524 and 800/972-3524. > From owner-ageing@net.bio.net Tue Dec 19 22:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!elroy.jpl.nasa.gov!swrinde!newsfeed.internetmci.com!uwm.edu!newsspool.doit.wisc.edu!news.doit.wisc.edu!F182-089.net.wisc.edu!harasha From: harasha@facstaff.wisc.edu (Brian) Newsgroups: bionet.molbio.ageing Subject: Cure for Death Date: Wed, 20 Dec 1995 13:57:08 Organization: UW-Madison Lines: 8 Message-ID: NNTP-Posting-Host: f182-089.net.wisc.edu X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] Is there any serious science reviews about the potential for immortality. I don't mean crackpot stuff or third grade journal articles. I saw the one in LIFE magazine a few years ago, but that was just sort of a random description of science projects that may be applied toward that goal. I mean physicists talk theoretically about concepts and potentialities that may seem ridiculous to contemplate now, but this has shown itself to be a great way to gain some inspiration and imagination. Why can't biologists do this? They seem so afraid to talk about it seriously. From owner-ageing@net.bio.net Tue Dec 19 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!swrinde!newsfeed.internetmci.com!in1.uu.net!news.goodnet.com!tempe41 From: nc07276@goodnet.com (N & D Cardenas) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: Lifelink Date: Wed, 20 Dec 95 06:14:09 GMT Organization: GoodNet, Inc. Lines: 21 Message-ID: <4b9quq$17l@news1.goodnet.com> References: <4b2f58$p7u@news.unicomp.net> NNTP-Posting-Host: tempe41.goodnet.com X-Newsreader: News Xpress Version 1.0 Beta #4 Xref: biosci bionet.molbio.ageing:2324 sci.life-extension:9268 In article <4b2f58$p7u@news.unicomp.net>, flaczko@conline.com (Frank L Laczko Sr.) wrote: >There were several references to Lifelink as a source for DHEA. Could >someone Post or E-mail me their address/phone number please. > >Thanks >Frank L Laczko Sr >flaczko@conline.com > Frank, I believe the below person, george, is LIFELINK. I have ordered from them/him and they seem good. - Daniel >greetings, the price i gave you on DHEA was wrong. the actual price >is $40 for 180-25 mg caps (2 for $75) if onterested please call me at >1-800-359-9896 thank you, george >gk@ix.netcom.com From owner-ageing@net.bio.net Wed Dec 20 22:00:00 1995 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Re: Cure for Death Date: 20 Dec 1995 21:56:41 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 20 Sender: daemon@net.bio.net Distribution: world Message-ID: References: NNTP-Posting-Host: net.bio.net Geron Corp. in Menlo Park, Ca., founded by Mike West and Miller Quarles, is scientifically approaching the 'cure'. They are pioneers in telomerase manipulation. They started with $50k a few years ago, now sustaining a $60 million research team. Japan now involved financially. They stand to experience windfall profits in the $billions with significant breakthroughs. Stock going public in '96. On Wed, 20 Dec 1995, Brian wrote: > Is there any serious science reviews about the potential for immortality. I > don't mean crackpot stuff or third grade journal articles. I saw the one in > LIFE magazine a few years ago, but that was just sort of a random description > of science projects that may be applied toward that goal. I mean physicists > talk theoretically about concepts and potentialities that may seem ridiculous > to contemplate now, but this has shown itself to be a great way to gain some > inspiration and imagination. Why can't biologists do this? They seem so afraid > to talk about it seriously. > > From owner-ageing@net.bio.net Wed Dec 20 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!nntp.crl.com!NewsWatcher!user From: mjensen@crl.com (Mark Jensen) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: Lifelink Date: Wed, 20 Dec 1995 19:45:42 -0800 Organization: Double J Apiaries Lines: 20 Message-ID: References: <4b2f58$p7u@news.unicomp.net> <4b9quq$17l@news1.goodnet.com> NNTP-Posting-Host: crl7.crl.com X-Newsreader: Value-Added NewsWatcher 2.0b27+ Xref: biosci bionet.molbio.ageing:2326 sci.life-extension:9274 In article <4b9quq$17l@news1.goodnet.com>, nc07276@goodnet.com (N & D Cardenas) wrote: > Frank, > > I believe the below person, george, is LIFELINK. I have ordered from > them/him and they seem good. > > - Daniel > > >greetings, the price i gave you on DHEA was wrong. the actual price > >is $40 for 180-25 mg caps (2 for $75) if onterested please call me at > >1-800-359-9896 thank you, george > >gk@ix.netcom.com Whoa there folks. gk is George Kuiper, who has been bombarding this group with ads and whose web site by the way doesn't work The real LifeLink is: delano@dax.win.net 805 473-1389. Mark Jensen Double J Apiaries mjensen@crl.com From owner-ageing@net.bio.net Wed Dec 20 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: meglos@aol.com (Meglos) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: Lifelink Date: 20 Dec 1995 21:14:51 -0500 Organization: America Online, Inc. (1-800-827-6364) Lines: 16 Sender: root@newsbf02.news.aol.com Message-ID: <4bafur$gc@newsbf02.news.aol.com> References: <4b9quq$17l@news1.goodnet.com> Reply-To: meglos@aol.com (Meglos) NNTP-Posting-Host: newsbf02.mail.aol.com Xref: biosci bionet.molbio.ageing:2325 sci.life-extension:9273 Yes, they seem a fine organization, and provided certification papers for the DHEA I purchased. In case anyone is interested, I experienced no noticable effect at 25 and 50 mg nightly dose of DHEA. At 100mg per night, there is a definite sense "of well-being" as mentioned in the reports. A curious sensation. My nightly regimen: 14 mg melatonin 100 mg DHEA 30 mg pregnenolone No depression - actually just the contrary - my work is *plenty* depressing (C++ software development), and yet since this regimen I just can't get really depressed about it any more - even though intellectually I know I should be. Curiouser still. Megs (meglos@alo.com) From owner-ageing@net.bio.net Wed Dec 20 22:00:00 1995 Path: biosci!CIS.OHIO-STATE.EDU!jj From: jj@CIS.OHIO-STATE.EDU (John Josephson) Newsgroups: bionet.molbio.ageing Subject: Re: Lifelink Date: 21 Dec 1995 03:58:15 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 24 Sender: daemon@net.bio.net Distribution: world Message-ID: <199512211156.GAA13153@columbus.cis.ohio-state.edu> References: <4bafur$gc@newsbf02.news.aol.com> NNTP-Posting-Host: net.bio.net > From: meglos@aol.com (Meglos) > Date: 20 Dec 1995 21:14:51 -0500 > > ... In case anyone is interested, I experienced no noticable effect > at 25 and 50 mg nightly dose of DHEA. At 100mg per night, there is a > definite sense "of well-being" as mentioned in the reports. A > curious sensation. My nightly regimen: > > 14 mg melatonin > 100 mg DHEA > 30 mg pregnenolone How old are you? How long have you been on this regime? Has your DHEA-S been tested since being on this regime to see how your blood levels compare with a normal (youthful) range? How soon after you went to the higher doseage of DHEA did you notice the improved sense of well-being? Aging minds/bodies need to know! Thanks, ..jj From owner-ageing@net.bio.net Wed Dec 20 22:00:00 1995 Newsgroups: bionet.molbio.ageing Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!ix.netcom.com!netcom.com!shankar From: shankar@netcom.com (Shankar Ramakrishnan) Subject: Re: Cure for Death Message-ID: Organization: VLSI Libraries Incorporated References: Date: Thu, 21 Dec 1995 19:07:58 GMT Lines: 38 Sender: vlsi_lib@netcom13.netcom.com In article dashley@TENET.EDU (Don Ashley) writes: >Geron Corp. in Menlo Park, Ca., founded by Mike West and Miller Quarles, is >scientifically approaching the 'cure'. They are pioneers in telomerase >manipulation. They started with $50k a few years ago, now sustaining a >$60 million research team. Japan now involved financially. > >They stand to experience windfall profits in the $billions with >significant breakthroughs. Stock going public in '96. I am interested in knowing how they wish to manipulate the telomerase of the cells in the human body. Is their product going to be just a drug or some other more complicated procedure with a certain risk factor involved? In any case, I believe that ageing is more than loss of telomerase. Also, there is a possibility that such manipulations can result in increased incidennce of cancer, since telomerase shortening may serve as a fuse to prevent the uncontrolled replication of potentially cancerous cells. Shankar > >On Wed, 20 Dec 1995, Brian wrote: > >> Is there any serious science reviews about the potential for immortality. I >> don't mean crackpot stuff or third grade journal articles. I saw the one in >> LIFE magazine a few years ago, but that was just sort of a random description >> of science projects that may be applied toward that goal. I mean physicists >> talk theoretically about concepts and potentialities that may seem ridiculous >> to contemplate now, but this has shown itself to be a great way to gain some >> inspiration and imagination. Why can't biologists do this? They seem so afraid >> to talk about it seriously. >> >> From owner-ageing@net.bio.net Thu Dec 21 22:00:00 1995 Path: biosci!agate!howland.reston.ans.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!cdc2.cdc.net!news1.cris.com!news From: gk Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: Lifelink Date: Thu, 21 Dec 1995 22:12:29 -0500 Organization: Cosmic Sales & Mkt., Inc. Lines: 31 Message-ID: <30DA221D.3A8C@cris.com> References: <4b2f58$p7u@news.unicomp.net> <4b9quq$17l@news1.goodnet.com> NNTP-Posting-Host: crc8-fddi.cris.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.0b3 (Win95; I) Xref: biosci bionet.molbio.ageing:2330 sci.life-extension:9292 Mark Jensen wrote: > > In article <4b9quq$17l@news1.goodnet.com>, nc07276@goodnet.com (N & D > Cardenas) wrote: > > > Frank, > > > > I believe the below person, george, is LIFELINK. I have ordered from > > them/him and they seem good. > > > > - Daniel > > > > >greetings, the price i gave you on DHEA was wrong. the actual price > > >is $40 for 180-25 mg caps (2 for $75) if onterested please call me at > > >1-800-359-9896 thank you, george > > >gk@ix.netcom.com > > Whoa there folks. gk is George Kuiper, who has been bombarding this group > with ads and whose web site by the way doesn't work The real LifeLink is: > delano@dax.win.net 805 473-1389. > > Mark Jensen Double J Apiaries mjensen@crl.com -- hey mark, you are h