From owner-ageing@net.bio.net Thu Aug 01 23:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!bcm.tmc.edu!pendragon!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!shore!mv!mv.mv.com!katel From: katel@mv.mv.com (Katharine Lindner) Subject: Re: Mitochondria oxidative damage? Message-ID: Organization: MV Communications, Inc. Date: Fri, 2 Aug 1996 06:16:06 GMT References: <4tg5nd$qlt@newsbf02.news.aol.com> X-Nntp-Posting-Host: mv.mv.com Lines: 33 mfossel@aol.com (MFossel) writes: >Incidentally, I agree vis a vis mitochondria: they are the major (95%) >source of intracellular free radicals and therefore one of the major >sources >of entropic damage within cells. The question is begged however (if we >call >them the only "cause" of aging) why have they been inherited flawlessly >(for >an estimate 1-2 billion years since they first took up residence in >eukaryotic cells) and yet "age" within a matter of decades within your >somatic cells? What times (or switches on) this sudden degradation in >function. It clearly occurs in somatic cells (you are correct) and yet it >clearly has not occurred within the inherited maternal germ cell line of >mitochondria for an astounding timespan. It is as though mitochondria are >biologically immortal (and homeostatically flawless) for billions of years >until you and I inherit them, and then go downhill almost instantly (in >comparison). This demands an explanation: telomere theory, senescent >gene >expression, and cell senescence offers one that is consistant, elegant, >and >predictive. So far (we'll see), this prediction has been borne out in the >laboratory... > Somewhere, I heard the idea that meiosis is a filter and cells with junk mitochondria get thrown away and other weak germ cells don't go on to become new animals. So they start out with OK mitochondria. I don't know if this is right or wrong. Kathy From owner-ageing@net.bio.net Thu Aug 01 23:00:00 1996 Path: biosci!aol.com!EdKrug From: EdKrug@aol.com Newsgroups: bionet.molbio.ageing Subject: Different cells, Different mechanisms Date: 2 Aug 1996 05:26:18 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 60 Sender: daemon@net.bio.net Distribution: world Message-ID: <960802082758_251191294@emout15.mail.aol.com> NNTP-Posting-Host: net.bio.net There seems to be a tacit assumption in the Aging research field that one mechanism or one small constellation of mechanisms must account for decline in function in all cells in all systems of any organism, the culminating effect of which is organism death. I contend that looking at aging from the perspective of "Evolution of Longeviety" offers some important insights into the task of increasing healthy lifespan. All that is essential in the evolution of apparently stable species-wide fixed lifespan is that the different processes limiting lifespan have roughly comparable times from start of timer to that point where sufficient deterioration in function or structure has occured that life has become untenably precarious or some cell has broken free of its internal and external supervision and started uninhibited replication. Of course you have to add in the individual variables of wear and tear, which is probably a bigger factor for humans than the caged rat, and you get this coodinated exhaustion of this multifacited "will to live" we call aging. Telomer shortening doesn't have to account for deterioration in non-replicating cells and culminating free radical damage doesn't have to account for the deterioration in replicating cells. They just have to have run their course with about the same finish time. Add in Advanced Glycosylation End products and one or two other other processes with the same rate of decline and then apply them to thousands of interacting systems in a complex multicellular organism and you get our problem in a nut shell. Using the "punctuated evolution" concept of Niles Eldredge, "Nature" has had to "improve" one limiting factor to life span after another to take multicellular organisms with a life span of one or two years and improve that number up to 100 years. There would be little selective advantage to fixing any individual limitation more than perhaps 10% beyond the other limiting factors. The creation of a new SOD (superoxide dismutase) might increase lifespan by 10%, but then some other factor becomes limiting and it too is "fixed" to produce another 10% in life span. The overall effect is that the multiple processes tearing away at living systems have all been compensated for at about comparable levels. Thus you get families of enzymes, multiple SODs, multiple receptors for the same hormone and so forth. Each one is a bit of fine tuning to the system given what is available. To present this last concept as an image: consider a group of children walking and the group can go no faster than the slowest child. You pick up and carry or "fix" the slowest child and now the group can go faster, but only as fast as the next slowest child. Each act of picking up or feeding another child so the group can go faster is a step in the punctuated evolution. Because this process has gone on for so many times the overall difference in speed between the children is not great, but it is still real. The more children in the group the more fixes needed. The speed of the group is the longeviety of an organism. Each fix, to be a fix, only has to speed the slowest child up so that it is no longer last. By way of adapting to the faster speed other changes take place within the group which do not necessarly alter the group speed, they just advantage of the new nitch in the world. Given the multicipicity of interactions our trick is to not discard any fix which improves some function but which doesn't address the current slowest child and increase the lifespan but may address a later slowest child. Sorry for the length. Ed Krug, Ph.D. Univ. of Colorado Health Sciences Center From owner-ageing@net.bio.net Thu Aug 01 23:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!bcm.tmc.edu!pendragon!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!hearst.acc.Virginia.EDU!murdoch!avery.med.Virginia.EDU!dsc9w From: dsc9w@avery.med.Virginia.EDU (David Cassarino) Subject: Re: Mitochondria oxidative damage? X-Nntp-Posting-Host: avery.med.virginia.edu Message-ID: Sender: usenet@murdoch.acc.Virginia.EDU Organization: uva References: <4tg35b$pp6@newsbf02.news.aol.com> Date: Fri, 2 Aug 1996 17:20:21 GMT Lines: 50 mfossel@aol.com writes: > Hello Gary. > > Mitochondria are one of the driving sources of aging damage within cells: > they produce about 95% of the free radicals and as the cell "ages", they > leak. You are, of course, right about the maternal source of mitchondria. > Remember, however that the maternal *germ cell* line of mitochondria has > not shown and sign of aging in the past 1-2 billion years since this > particular organelle first took up permanent residence within eukaryotic > cells. Although (retrospectively in surviving germ cell line > mitochondria) they have not age, they show oxidative degradation within a > few decades in human somatic cells. This implies that non-mitochondrial > (eg, nuclear genes, etc) factors determine mitochondrial "aging", not > merely mitochondrial damage *per se*. Not necessarily. Mitochondria in the maternal germ cells are basically inactive (there may not even be any oxidative metabolism in dormant germ cells-?) compared to mitochondria in active neurons and other cells. I don't know the actualy numbers, but the amount of free radicals produced by respiring mitochondria is probably many orders of magnitude greater than that produced by dormant germ cell mitos. So it is no wonder that most damage to mito DNA occurs in somatic cells, and may not even be detectable into adulthood. CNS neuronal mito DNA is also especially vulnerable to damage due to relatively large free radical production (especially in catecholaminergic cells, like the substantia nigra, which decays in Parkinson's disease) and insufficient free rad defenses. Also, natural selection would tend to eliminate those mitos in the germ line that had significant mutations--or at least those embrios unlucky enough to inherit them! Telomere theory of aging suggests > that homeostatic defences against (among other things) mitochondrial > oxidative damage are "down-regulated" as the telomere shortens. Far from > being mutually exclusive, mitochondrial damage plays a pivotal role in the > intracellular aging process in telomere aging theory. The same in true of > cumulative DNA damage (and down-regulation of DNA repair), protein > turnover rates, etc. Thanks for your thoughts: you are pretty close to > hitting the nail on the head > > Best wishes, > Michael Fossel, MD, PhD > Author, Reversing Human Aging -- David S. Cassarino "The mind is not a vessel to be filled MSTP, Neuroscience 2nd Year but a fire to be kindled." UVA School of Medicine -Plutarch dsc9w@virginia.edu From owner-ageing@net.bio.net Thu Aug 01 23:00:00 1996 Path: biosci!daresbury!hgmp.mrc.ac.uk!plinehan From: plinehan@hgmp.mrc.ac.uk (Mr. P.F. Linehan) Newsgroups: bionet.molbio.ageing,fj.life.health,misc.health.aids,misc.health.alternative,sci.life-extension Subject: Re: Fighting Cellular Deteriation Date: 2 Aug 1996 16:27:51 GMT Organization: MRC Human Genome Resource Centre Lines: 5 Message-ID: <4ttaa7$eld@mercury.hgmp.mrc.ac.uk> References: <4tt1b1$hlr$1@mhadf.production.compuserve.com> NNTP-Posting-Host: tin.hgmp.mrc.ac.uk Xref: biosci bionet.molbio.ageing:2903 misc.health.aids:13624 misc.health.alternative:78042 sci.life-extension:13903 test From owner-ageing@net.bio.net Thu Aug 01 23:00:00 1996 Path: biosci!agate!newsgate.duke.edu!news.mathworks.com!newsfeed.internetmci.com!news.compuserve.com!news.production.compuserve.com!news From: Wayne Corbett <70004.2761@CompuServe.COM> Newsgroups: bionet.molbio.ageing,fj.life.health,misc.health.aids,misc.health.alternative,sci.life-extension Subject: Fighting Cellular Deteriation Date: 2 Aug 1996 13:54:41 GMT Organization: CompuServe, Inc. (1-800-689-0736) Lines: 16 Message-ID: <4tt1b1$hlr$1@mhadf.production.compuserve.com> Xref: biosci bionet.molbio.ageing:2902 misc.health.aids:13617 misc.health.alternative:78033 sci.life-extension:13901 "REVENOL 60+OPCs" includes what we believe is the most powerful antioxident known to nature to fight against free radicals that attack our bodies every day. OPCs from pycnogenols (extracted from curcuminoids, grape seeds and maritime pine bark) have been combined into this free radical fighting powerfhouse formula. Curcuminoids are extracted from Tumeric which has very powerful anti-viral compounds and is vastly superior to other antioxidents. The OPCs in REVENOL are designed to fight environmental agents causing cellular deteriation and other critical tissue damage resulting from stray oxygen atoms and free radicals.(Neways Product Usage Catalog) Wayne Corbett,independent distributor,70004,2761@compuserve.com -- Wayne Corbett, 70004,2761@compuserve.com Life is a school for the soul From owner-ageing@net.bio.net Fri Aug 02 23:00:00 1996 Path: biosci!agate!ihnp4.ucsd.edu!news1.ucsd.edu!usenet From: Oliver Bogler Newsgroups: bionet.molbio.ageing Subject: Re: Different cells, Different mechanisms Date: Fri, 02 Aug 1996 17:12:23 -0700 Organization: The University of California at San Diego Lines: 40 Message-ID: <32029967.1917@ucsd.edu> References: <960802082758_251191294@emout15.mail.aol.com> NNTP-Posting-Host: licr-user003.ucsd.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.01 (Macintosh; I; 68K) EdKrug@aol.com wrote: > > There seems to be a tacit assumption in the Aging research field that one > mechanism or one small constellation of mechanisms must account for decline > in function in all cells in all systems of any organism, the culminating > effect of which is organism death. I contend that looking at aging from the > perspective of "Evolution of Longeviety" offers some important insights into > the task of increasing healthy lifespan. > (more that was cut) Dear Ed, I found your post interesting and that it makes an excellent point: it is veyy common in biology to extrapolate from one system to others, and to assume that mechanisms apply very generally. Your point that different cells age in different ways is dead on, in my opinion. Clearly, some cells, such as the uninterrupted germ cell line never age. I'd like to add my thoughts on your evolutionary argument: 1) I don't believe that there is *any* evolutionary pressure to extend life. Most populations of animals in the wild never reach their maximum age limit, which can be seen in captivity. This is because of predation and disease, as well as fluctuations in food supply etc. Evolution can't act on something that has no selective impact. Humans are no different - the recent leap in life-expectancy is due to removal of environmental life limiting influences. 2) In any case, I would turn the whole thing upside down, and say that ageing is an acquired strategy in terms of the evolution of life, and is beneficial to a sexually evloving species. The reason I say it is acquired is that primitive organisms, such as bacteria, do not age - they just divide again and again in an unending generational chain (under ideal circumstances - of course they can succumb to environmental damage). It is only eukaryotic cells that begin to show ageing, and even there some show much less than others. Of course, when you consider the germ line as a lineage of cells that exists in many different individuals you can see that it doesn't age either - the DNA in you is a copy from the first human, which has not been degraded by cosmic rays, or radicals etc. over the last few hundred thousand years. Why? Because when nature wants to stop/prevent ageing processes it can. It just wouldn't be good for evolution ie. species that don't age and turn over their generations quickly enough are not competitive in the big game of natural selection. From owner-ageing@net.bio.net Fri Aug 02 23:00:00 1996 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.ageing Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 3 Aug 1996 02:00:11 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 239 Sender: daemon@net.bio.net Distribution: world Message-ID: <199608030900.CAA18896@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. 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For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From owner-ageing@net.bio.net Sun Aug 04 23:00:00 1996 Path: biosci!agate!spool.mu.edu!uwm.edu!cs.utexas.edu!howland.reston.ans.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!in3.uu.net!psinntp!psinntp!psinntp!usenet From: jmsdean@pipeline.com Newsgroups: bionet.molbio.ageing Subject: president of LEF on Tony Brown's Journal Date: 5 Aug 1996 01:51:39 GMT Organization: PSINet/Pipeline USA Lines: 9 Message-ID: <4u3k3b$t8m@news2.h1.usa.pipeline.com> NNTP-Posting-Host: 38.8.61.2 i just watch a Tony Brown show in which he interviewed the president i think of the LEF, Life Extension Foundation. i think his name was like Fallon? anyway... the president of the LEF was saying that melatonin is the best anti-oxidant because it can penetrate every single cells membrane. 100% permeability. is this true? luke From owner-ageing@net.bio.net Sun Aug 04 23:00:00 1996 Path: biosci!NANOTHINC.COM!tess From: tess@NANOTHINC.COM (Tess Mercer) Newsgroups: bionet.molbio.ageing Subject: Call for Papers Date: 5 Aug 1996 14:18:06 -0700 Organization: Nanothinc Lines: 57 Sender: daemon@net.bio.net Distribution: world Message-ID: <3206035E.6598@nanothinc.com> Reply-To: tess@nanothinc.com NNTP-Posting-Host: net.bio.net Topical Overview: Call for Papers - Nanobiology: Research, Theory, and Current Applications Nanotechnology, as a general topic, covers a very wide array of different disciplines and areas of research. However, in the realm of biological and biomolecular applications and developments, there are a number of current examples, including some commercial applications, which are reshaping the approach to which previously difficult, or even "unsolvable" procedures can now be resolved, or greatly improved upon. It is specifically in the realm of thoeretical, near term, or currently available technologies, and how they are affected by application of "nanobiological" processes, that will be reviewed in this section of the journal. By definition, a nanobiological process could be described, in this context, as any process which utilizes the contrived manipulation of individual biomolecules or biomolecular structures to fullfill a desired task, create an object, a material or application of a material, or as an intermediate step in fullfilling a multistaged series of assembly or construction tasks involving biomolecular materials. This definition could also be expanded to include the methodologies of visualiztion or detection of nanoscale activities in a biomolecular environment, or in the development of instrumentation and processes related to these tasks. Also, there are other tangential aspects of nanobiological processes which are also relevant, and deserve attention. Particularly in the areas of potential nanoscale computing or information processing applications which may utilize or incorporate biological components or processes, there has been considerable interest and research ativities. Please let us know if you are interested. Information about our company, Nanothinc, can be found at http://www.nanothinc.com. Also, I have additional Notes for Contributors which I can fax to your attention. Sincerely, Maritess T. Mercer Director of Administration Project Manager Nanothinc 1797 Union Street San Francisco, CA 94123 Tel: (415) 202-9969, Fax: (415) 202-9975 URL: http://www.nanothinc.com Email: tess@nanothinc.com From owner-ageing@net.bio.net Sun Aug 04 23:00:00 1996 Path: biosci!SMTPLINK.COH.ORG!dtran From: dtran@SMTPLINK.COH.ORG ("TRAN, DUKE") Newsgroups: bionet.molbio.ageing Subject: Re: Call for Papers Date: 5 Aug 1996 16:27:09 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 72 Sender: daemon@net.bio.net Distribution: world Message-ID: <9607058392.AA839287764@smtplink.coh.org> NNTP-Posting-Host: net.bio.net Please unscribe System Administrator ______________________________ Reply Separator _________________________________ Subject: Call for Papers Author: tess@NANOTHINC.COM at INTERNET Date: 8/5/96 2:33 PM Topical Overview: Call for Papers - Nanobiology: Research, Theory, and Current Applications Nanotechnology, as a general topic, covers a very wide array of different disciplines and areas of research. However, in the realm of biological and biomolecular applications and developments, there are a number of current examples, including some commercial applications, which are reshaping the approach to which previously difficult, or even "unsolvable" procedures can now be resolved, or greatly improved upon. It is specifically in the realm of thoeretical, near term, or currently available technologies, and how they are affected by application of "nanobiological" processes, that will be reviewed in this section of the journal. By definition, a nanobiological process could be described, in this context, as any process which utilizes the contrived manipulation of individual biomolecules or biomolecular structures to fullfill a desired task, create an object, a material or application of a material, or as an intermediate step in fullfilling a multistaged series of assembly or construction tasks involving biomolecular materials. This definition could also be expanded to include the methodologies of visualiztion or detection of nanoscale activities in a biomolecular environment, or in the development of instrumentation and processes related to these tasks. Also, there are other tangential aspects of nanobiological processes which are also relevant, and deserve attention. Particularly in the areas of potential nanoscale computing or information processing applications which may utilize or incorporate biological components or processes, there has been considerable interest and research ativities. Please let us know if you are interested. Information about our company, Nanothinc, can be found at http://www.nanothinc.com. Also, I have additional Notes for Contributors which I can fax to your attention. Sincerely, Maritess T. Mercer Director of Administration Project Manager Nanothinc 1797 Union Street San Francisco, CA 94123 Tel: (415) 202-9969, Fax: (415) 202-9975 URL: http://www.nanothinc.com Email: tess@nanothinc.com From owner-ageing@net.bio.net Tue Aug 06 23:00:00 1996 Path: biosci!biosci!not-for-mail From: a.c.noorlandt@chem.ruu.nl (Albert Noorlandt) Newsgroups: bionet.biophysics,bionet.cellbiol,bionet.immunology,bionet.metabolic-reg,bionet.molbio.ageing,bionet.molbio.methds-reagnts,bionet.molbio.proteins,bionet.molbio.proteins.7tms_r,alt.med,alt.pharm,sci.bio.misc,sci.chem,sci.chem.analytical,sci.med,sci.misc,sci.techniques Subject: 1997 FEBS Meeting on Cell Signalling Mechanisms Date: 6 Aug 1996 17:24:42 -0700 Organization: CBLE Lines: 29 Sender: biohelp@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Xref: biosci bionet.biophysics:2198 bionet.cellbiol:5225 bionet.immunology:9491 bionet.metabolic-reg:805 bionet.molbio.ageing:2916 bionet.molbio.methds-reagnts:47700 bionet.molbio.proteins:8451 bionet.molbio.proteins.7tms_r:804 sci.bio.misc:4117 sci.chem:61653 sci.chem.analytical:5118 sci.med:133749 sci.misc:12601 FEBS Special Meeting on Cell Signalling Mechanisms, From membrane to nucleus Amsterdam, The Netherlands, June 29­July 3, 1997 Everything you want to know about this meeting on www-page: http://www.cble.chem.ruu.nl/febs97/index.html The meeting will cover the following topics: € Tyrosine kinases € MAP-, Ser/Thr-kinases € G-coupled receptors € Lymphokine receptors € Ras, Rac, Rho-proteins € Ca2+, cGMP, NO € Lipid signalling € Steroid receptors € Transcription factors € Cell cycle, Apoptosis For further information contact: Secretariat FEBS Special Meeting 1997 Lidy Groot Congress Events P.O. Box 83005 1080 AA Amsterdam The Netherlands Tel. +31.20.679 3218 Fax: +31.20.675 8236 Email: lidy.groot@inter.nl.net From owner-ageing@net.bio.net Tue Aug 06 23:00:00 1996 Path: biosci!agate!howland.reston.ans.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!in3.uu.net!psinntp!psinntp!psinntp!usenet From: jmsdean@pipeline.com Newsgroups: bionet.molbio.ageing Subject: a question on nanotechnology Date: 7 Aug 1996 12:24:32 GMT Organization: PSINet/Pipeline USA Lines: 6 Message-ID: <4ua1u0$ml5@news2.h1.usa.pipeline.com> NNTP-Posting-Host: 38.8.61.2 if nanotechnology is simply the manipulation of molecules, is taking any drug, let's say prozac, which blocks the reuptake of the serotonin molecule on the sending side of the synapse, kind of like a primitive form of nanotechnology? luke From owner-ageing@net.bio.net Wed Aug 07 23:00:00 1996 Path: biosci!agate!newsgate.duke.edu!news.mathworks.com!newsfeed.internetmci.com!EU.net!sun4nl!Inter.NL.net!usenet From: Angelo Schouten PhD Chem Newsgroups: bionet.molbio.ageing,fj.life.health,misc.health.aids,misc.health.alternative,sci.life-extension Subject: Re: Fighting Cellular Deteriation Crap Date: Thu, 08 Aug 1996 13:27:42 +0200 Organization: Inter.NL.net, The Internet Provider in The Netherlands. Lines: 20 Message-ID: <3209CF2E.4E16@akam.nl> References: <4tt1b1$hlr$1@mhadf.production.compuserve.com> NNTP-Posting-Host: ldn51-8.leiden.nl.net Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 8bit X-Mailer: Mozilla 2.01 (Win95; I) To: Wayne Corbett <70004.2761@CompuServe.COM> Xref: biosci bionet.molbio.ageing:2918 misc.health.aids:13955 misc.health.alternative:78644 sci.life-extension:14040 Wayne Corbett wrote: > "REVENOL 60+OPCs"[snip commercial crap] > Wayne Corbett, 70004,2761@compuserve.com Wayne, this newsgroup is not for advertising. It must be clear to you that advertising costs money. So pay for it accordingly. And considering the public in Usenet you want to reach, the fees must be enormous and your firm becomes ... bankrupt. Anyway your ad is stupidious and a blatant insult to usenet. > Life is a school for the soul It is very obvious that you´ve been never to school The next time I will report you to the Black list of the Internet, the result of which has to experienced by you only. Did I make myself clear? Regards, Angelo Schouten From owner-ageing@net.bio.net Wed Aug 07 23:00:00 1996 Path: biosci!agate!howland.erols.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!usenet.eel.ufl.edu!arclight.uoregon.edu!dispatch.news.demon.net!demon!mail2news.demon.co.uk!longevb.demon.co.uk From: John de Rivaz Newsgroups: bionet.molbio.ageing Subject: Re: a question on nanotechnology Date: Thu, 08 Aug 1996 11:09:02 +0100 Organization: Myorganisation Lines: 31 Message-ID: <893363732wnr@longevb.demon.co.uk> References: <4ua1u0$ml5@news2.h1.usa.pipeline.com> Reply-To: John@longevb.demon.co.uk X-NNTP-Posting-Host: longevb.demon.co.uk X-Newsreader: Newswin Alpha 0.9.1 X-Mail2News-Path: relay-4.mail.demon.net!post.demon.co.uk!longevb.demon.co.uk In article: <4ua1u0$ml5@news2.h1.usa.pipeline.com> jmsdean@pipeline.com writes: > > if nanotechnology is simply the manipulation of molecules, is taking any > drug, let's say prozac, which blocks the reuptake of the serotonin molecule > on the sending side of the synapse, kind of like a primitive form of > nanotechnology? > > luke > > In theory, yes, but it is confusing to think like this. "Real" nanotechnology is building machines using individual atoms and molectles as working parts. There are some nanotechnology articles on my web site under "free reports" from the home page. -- Sincerely, **************************************** * Publisher of Longevity Report * John de Rivaz * Fractal Report * * details on request * **************************************** In the information age, sharing can increase world wealth enormously, because giving information does not decrease your information. http://ourworld.compuserve.com/homepages/JohndeR Fast loading, very few slow pictures From owner-ageing@net.bio.net Thu Aug 08 23:00:00 1996 Path: biosci!agate!howland.erols.net!news2.digex.net!news5.digex.net!haven.umd.edu!news.umbc.edu!usenet@news.umbc.edu From: Lou Ehudin Newsgroups: bionet.molbio.ageing Subject: Need fast cash? Date: Fri, 09 Aug 1996 17:12:39 -0400 Organization: University of Maryland, Balitmore County Lines: 234 Message-ID: <320BA9C7.9D3@gl.umbc.edu> NNTP-Posting-Host: umbc8.umbc.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit NNTP-Posting-User: lehudi1 X-Mailer: Mozilla 2.0 (Win95; I) Hello! I've got some awesome news that I think you need to take two minutes to read if you have ever thought "How could I make some serious cash in a hurry???" , or been in serious debt, ready to do almost anything to get the money needed to pay off those bill collectors. So grab a snack, a warm cup of coffee, or a glass of your favorite beverage, get comfortable and listen to this interesting, exciting find! Let me start by saying that I FINALLY FOUND IT! That's right! I found it! And I HATE GET RICH QUICK SCHEMES!! I hate those schemes like multi-level marketing, mail-order schemes, envelope stuffing scams, 900 number scams... the list goes on forever. I have tried every darn get rich quick scheme out there over the past 12 years. I somehow got on mailing lists for people looking to make money (more like 'desperate stupid people who will try anything for money!'). Well, when I was a teenager, these claims to 'get me rich quick' sounded irresistible! I would shell out $14.95 here, $29.95 there, $24.95 here, and another $49.95 there. I had maxed out my new Circuit City Card AND my Visa...I was desperate for money!! So, I gave them all a chance but failed at every one of them! Maybe they worked for some people, but not for me. Eventually, I just tossed that JUNK MAIL in the trash when I got the mail. I recognized it right away. I can smell a money scam from a mile away these days, SO I THOUGHT.... I thought I could sniff out a scam easily. WAS I WRONG!! ....I LOVE THE INTERNET!!! I was scanning thru a NEWSGROUP and saw an article stating to GET CASH FAST!! I thought..."Here on the Internet?? Well, I'll just have to see what schemes could possibly be on the internet." The article described a way to MAIL A ONE DOLLAR BILL TO ONLY FIVE PEOPLE AND MAKE $50, 0000 IN CASH WITHIN 4 WEEKS! Well, the more I thought about it, the more I became very curious. Why? Because of the way it worked AND BECAUSE IT WOULD ONLY COST ME FIVE DOLLARS (AND FIVE STAMPS), THAT'S ALL I EVER PAY....EVER!! Ok, so the $50,000 in cash was maybe an tough amount to reach, but it was possible. I knew that I could at least get a return of $1,000 or so. So I did it!! As per the instructions in the article, I mailed out ('snail mail'for you e-mail fanatics) a single dollar bill to each of the five people on the list that was contained in the article. I included a small note, with the dollar, that stated "Please Add Me To Your List." I then removed the first position name of the five names listed and moved everyone up one position, and I put my name in position five of the list. This is how the money starts rolling in! I then took this revised article now with my name on the list and REPOSTED IT ON AS MANY NEWSGROUPS AND LOCAL BULLETIN BOARD MESSAGE AREAS THAT I KNEW. I then waited to watch the money come in...prepared to maybe receive about $1000 to $1500 in cash or so.... But what a welcome surprise when those envelopes kept coming in!!! I knew what they were as soon as I saw the return addresses from people all over the world-Most from the U.S., but some from Canada, even some from Australia! I tell you, THAT WAS EXCITING!! So how much did I get in total return? $1000? $5000? Not even!!! I received a total of $23,343!!! I couldn't believe it!! I now have a brand new black Acura Integra to speak for, due to this!! Now after almost 8 months, I am ready to do it again!!! So maybe it was possible to get $50,000 in cash, I don't know, but IT COMPLETELY DEPENDS ON YOU, THE INDIVIDUAL! You must follow through and repost this article everywhere you can think of! The more postings you achieve will determine how much cash will arrive in your very own mailbox!! It's just too easy to pass up!!! Let's review the reasons why you should do this: The only cost factors are for the five stamps, the 5 envelopes and the 5 one dollar bills that you send out to the listed names by snail mail (US Postal Service Mail). Then just simply repost the article (WITH YOUR NAME ADDED) to all the newsgroups and local BBS's you can. Then sit back and, (ironically), enjoy walking (you can run if you like! :o ) down your driveway to your mailbox and scoop up your rewards!! We all have five dollars to put into such an easy effortless investment with SPECTACULAR REALISTIC RETURNS OF $15,000 to $25,000 in about 3-5 weeks! So HOLD OFF ON THOSE LOTTERY NUMBERS FOR TODAY,EAT AT HOME TONIGHT INSTEAD OF TAKEOUT FROM McDONALDS AND INVEST FIVE DOLLARS IN THIS AMAZING MONEY MAKING SYSTEM NOW!!! YOU CAN'T LOSE!! So how do you do it exactly, you ask? I have carefully provided the most detailed, yet straight forward instructions on how to easily get this underway and get your cash on its way. SO, ARE YOU READY TO MAKE SOME CASH!!!?? HERE WE GO!!! *** THE LIST OF NAMES IS AT THE END OF THIS ARTICLE. *** OK, Read this carefully. Get a printout of this information, if you like, so you can easily refer to it as often as needed. INSTRUCTIONS: 1. Take a sheet of paper and write on it the following: "Please add my name to your list". This creates a service out of this money making system and thus making it completely legal. You are not just randomly sending a dollar to someone, you are paying one dollar for a legitimate service. Make sure you include your name and address. I assure you that, again, this is completely legal! For a neat little twist, also write what slot their name was in: "You were in slot 3", Just to add a little fun! This is all about having fun and making money at the same time! 2. Now fold this sheet of paper around a dollar bill ,(no checks or money orders), and put them into an envelope and send it on its way to the five people listed. The folding of the paper around the bill will insure its arrival to its recipient. THIS STEP IS IMPORTANT!! 3. Now listen carefully, here's where you get YOUR MONEY COMING TO YOUR MAILBOX. Look at the list of five people; remove the first name from position one and move everyone on the list up slot one on the list. Position 2 name will now move to the position 1 slot , position 3 will now become position 2, 4 will be be 3, 5 wil be 4. Now put your name, address, zipcode AND COUNTRY in position 5, the bottom position on the list. 4. Now upload this updated file to as many newsgroups and local bulletin boards' message areas & file section as possible. Give a catchy description of the file so it gets noticed!! Such as: "NEED FAST CASH?, HERE IT IS!" or "NEED CASH TO PAY OFF YOUR DEBTS??", etc. And the more uploads, the more money you will make, and of course, the more money the others on the list will make too. LET'S ALL TAKE CARE OF EACH OTHER BY BEING HONEST AND BY PUTTING FORTH 120 PERCENT INTO THIS PROFITABLE & AMAZING SYSTEM!!! You'll reap the benefits, believe me!!! Set a goal for the number of total uploads you'll post, such as 15-20 postings or more! Always have a goal in mind!!! If you can UUE encode the file when uploading, that will make it easier for the people to receive it and have it downloaded to their hard drive. That way they get a copy of the article right on their computer without hassles of viewing and then saving the article from the File menu. Don't alter the file type, leave it as an MS-DOS Text file. The best test is to be able to view this file using Microsoft's Notepad for Windows 3.x or WordPad for Windows '95. If the margins look right without making the screen slide left or right when at the ends of the sentences, you're in business! 5. If you need help uploading, simply ask the sysop of the BBS, or "POST" a message on a newsgroup asking how to post a file, tell them who your Internet provider is and PEOPLE WILL ALWAYS BE GLAD TO HELP. I would try to describe how to do it but there are simply too many internet software packages with slightly different yet relatively simple ways to post or upload a file. Just ask for help or look in the help section for 'posting'. I do know that for GNN, you simply select 'POST' then enter a catchy description under the subject box, choose 'ATTACH', selecting 'UUE' and NOT 'TXT', then choose 'Browse' to go look for the file. Find your text file CASH.TXT and click on it and choose 'OK'. Place a one line statement in the main body section of the message post screen. Something like "Download this to read how to get cash arriving in your mailbox with no paybacks!" or whatever. Just make sure it represents its true feasibility, NOT something like... "Get one million dollars flooding in your mailbox in two days!" You'll never get ANY responses! 6. And this is the step I like. JUST SIT BACK AND ENJOY LIFE BECAUSE CASH IS ON ITS THE WAY!! Expect to see a little money start to trickle in around 2 weeks, but AT ABOUT WEEKS 3 & 4, THE MONEY STORM WILL HIT YOUR MAILBOX!! All you have to do is take it out of the mailbox and try not to scream too loud (outside anyway) when you realize YOU HIT THE BIG TIME AT LAST!! 7. So go PAY OFF YOUR BILLS AND DEBTS and then get that something special you always wanted or buy that special person in your life (or the one you want in your life) a gift they'll never forget. ENJOY LIFE! 8. Now when you get low on this money supply, simply re-activate this file again; Reposting it in the old places where you originally posted and possibly some new places you now know of. Don't ever lose this file, always keep a copy at your reach for when you ever need cash. THIS IS AN INCREDIBLE TOOL THAT YOU CAN ALWAYS RE-USE TIME AND TIME AGAIN WHEN CASH IS NEEDED! ******************************************************************* ******************************************************************* THE NAMES LIST THE NAMES LIST THE NAME LIST ******************************************************************* * HONESTY IS WHAT MAKES THIS PROGRAM SUCCESSFUL!!! * * * 1. Martha Torres * 127 N. Kenwood St. * Burbank, CA 91505 * * 2. Elizabeth Porrello * P.O. Box 612 * Glenwood Landing, NY 11547-0612 * U.S.A. * * 3. Jack Pang * 1003 E. Hellman Ave. #41 * Monterey Park, CA 91755-1457 * * 4. Keith lang * 637 Cimarron Trail * Irving, TX 75063 * * 5. Lou Ehudin * 4 Trolod Ct. Apt. F1 * Owings Mills, MD 21117 * * **************************************************************** NOTE: Try to keep a list of everyone that sends you a dollar and always keep an eye on the local postings of this file...Just to make sure that everyone is playing the game fairly. You know where your name should be..... AGAIN, HONESTY IS THE BEST THING WE HAVE GOING FOR US ON THIS PLAN. -Mike Dotson, Boulder, CO *********************************************************************** By the way, if you try to deceive people by posting the messages with your name in the list and not sending the money to the people already included, you will not get much. I know someone who did this and only got about $150 (and that's after two months). Then he sent the 5 bills, people added him to their lists, and in 4-5 weeks he had over $10000! All the lists are re-distributed as soon as the money is received. End of article From owner-ageing@net.bio.net Fri Aug 09 23:00:00 1996 Path: biosci!agate!howland.erols.net!news1.erols.com!news.bconnex.net!news.abs.net!cs.umd.edu!haven.umd.edu!news.umbc.edu!usenet@news.umbc.edu From: Lou Ehudin Newsgroups: bionet.molbio.ageing Subject: Need fast cash? Date: Fri, 09 Aug 1996 16:36:13 -0400 Organization: University of Maryland, Balitmore County Lines: 234 Message-ID: <320BA13D.7681@gl.umbc.edu> NNTP-Posting-Host: umbc8.umbc.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit NNTP-Posting-User: lehudi1 X-Mailer: Mozilla 2.0 (Win95; I) Hello! I've got some awesome news that I think you need to take two minutes to read if you have ever thought "How could I make some serious cash in a hurry???" , or been in serious debt, ready to do almost anything to get the money needed to pay off those bill collectors. So grab a snack, a warm cup of coffee, or a glass of your favorite beverage, get comfortable and listen to this interesting, exciting find! Let me start by saying that I FINALLY FOUND IT! That's right! I found it! And I HATE GET RICH QUICK SCHEMES!! I hate those schemes like multi-level marketing, mail-order schemes, envelope stuffing scams, 900 number scams... the list goes on forever. I have tried every darn get rich quick scheme out there over the past 12 years. I somehow got on mailing lists for people looking to make money (more like 'desperate stupid people who will try anything for money!'). Well, when I was a teenager, these claims to 'get me rich quick' sounded irresistible! I would shell out $14.95 here, $29.95 there, $24.95 here, and another $49.95 there. I had maxed out my new Circuit City Card AND my Visa...I was desperate for money!! So, I gave them all a chance but failed at every one of them! Maybe they worked for some people, but not for me. Eventually, I just tossed that JUNK MAIL in the trash when I got the mail. I recognized it right away. I can smell a money scam from a mile away these days, SO I THOUGHT.... I thought I could sniff out a scam easily. WAS I WRONG!! ....I LOVE THE INTERNET!!! I was scanning thru a NEWSGROUP and saw an article stating to GET CASH FAST!! I thought..."Here on the Internet?? Well, I'll just have to see what schemes could possibly be on the internet." The article described a way to MAIL A ONE DOLLAR BILL TO ONLY FIVE PEOPLE AND MAKE $50, 0000 IN CASH WITHIN 4 WEEKS! Well, the more I thought about it, the more I became very curious. Why? Because of the way it worked AND BECAUSE IT WOULD ONLY COST ME FIVE DOLLARS (AND FIVE STAMPS), THAT'S ALL I EVER PAY....EVER!! Ok, so the $50,000 in cash was maybe an tough amount to reach, but it was possible. I knew that I could at least get a return of $1,000 or so. So I did it!! As per the instructions in the article, I mailed out ('snail mail'for you e-mail fanatics) a single dollar bill to each of the five people on the list that was contained in the article. I included a small note, with the dollar, that stated "Please Add Me To Your List." I then removed the first position name of the five names listed and moved everyone up one position, and I put my name in position five of the list. This is how the money starts rolling in! I then took this revised article now with my name on the list and REPOSTED IT ON AS MANY NEWSGROUPS AND LOCAL BULLETIN BOARD MESSAGE AREAS THAT I KNEW. I then waited to watch the money come in...prepared to maybe receive about $1000 to $1500 in cash or so.... But what a welcome surprise when those envelopes kept coming in!!! I knew what they were as soon as I saw the return addresses from people all over the world-Most from the U.S., but some from Canada, even some from Australia! I tell you, THAT WAS EXCITING!! So how much did I get in total return? $1000? $5000? Not even!!! I received a total of $23,343!!! I couldn't believe it!! I now have a brand new black Acura Integra to speak for, due to this!! Now after almost 8 months, I am ready to do it again!!! So maybe it was possible to get $50,000 in cash, I don't know, but IT COMPLETELY DEPENDS ON YOU, THE INDIVIDUAL! You must follow through and repost this article everywhere you can think of! The more postings you achieve will determine how much cash will arrive in your very own mailbox!! It's just too easy to pass up!!! Let's review the reasons why you should do this: The only cost factors are for the five stamps, the 5 envelopes and the 5 one dollar bills that you send out to the listed names by snail mail (US Postal Service Mail). Then just simply repost the article (WITH YOUR NAME ADDED) to all the newsgroups and local BBS's you can. Then sit back and, (ironically), enjoy walking (you can run if you like! :o ) down your driveway to your mailbox and scoop up your rewards!! We all have five dollars to put into such an easy effortless investment with SPECTACULAR REALISTIC RETURNS OF $15,000 to $25,000 in about 3-5 weeks! So HOLD OFF ON THOSE LOTTERY NUMBERS FOR TODAY,EAT AT HOME TONIGHT INSTEAD OF TAKEOUT FROM McDONALDS AND INVEST FIVE DOLLARS IN THIS AMAZING MONEY MAKING SYSTEM NOW!!! YOU CAN'T LOSE!! So how do you do it exactly, you ask? I have carefully provided the most detailed, yet straight forward instructions on how to easily get this underway and get your cash on its way. SO, ARE YOU READY TO MAKE SOME CASH!!!?? HERE WE GO!!! *** THE LIST OF NAMES IS AT THE END OF THIS ARTICLE. *** OK, Read this carefully. Get a printout of this information, if you like, so you can easily refer to it as often as needed. INSTRUCTIONS: 1. Take a sheet of paper and write on it the following: "Please add my name to your list". This creates a service out of this money making system and thus making it completely legal. You are not just randomly sending a dollar to someone, you are paying one dollar for a legitimate service. Make sure you include your name and address. I assure you that, again, this is completely legal! For a neat little twist, also write what slot their name was in: "You were in slot 3", Just to add a little fun! This is all about having fun and making money at the same time! 2. Now fold this sheet of paper around a dollar bill ,(no checks or money orders), and put them into an envelope and send it on its way to the five people listed. The folding of the paper around the bill will insure its arrival to its recipient. THIS STEP IS IMPORTANT!! 3. Now listen carefully, here's where you get YOUR MONEY COMING TO YOUR MAILBOX. Look at the list of five people; remove the first name from position one and move everyone on the list up slot one on the list. Position 2 name will now move to the position 1 slot , position 3 will now become position 2, 4 will be be 3, 5 wil be 4. Now put your name, address, zipcode AND COUNTRY in position 5, the bottom position on the list. 4. Now upload this updated file to as many newsgroups and local bulletin boards' message areas & file section as possible. Give a catchy description of the file so it gets noticed!! Such as: "NEED FAST CASH?, HERE IT IS!" or "NEED CASH TO PAY OFF YOUR DEBTS??", etc. And the more uploads, the more money you will make, and of course, the more money the others on the list will make too. LET'S ALL TAKE CARE OF EACH OTHER BY BEING HONEST AND BY PUTTING FORTH 120 PERCENT INTO THIS PROFITABLE & AMAZING SYSTEM!!! You'll reap the benefits, believe me!!! Set a goal for the number of total uploads you'll post, such as 15-20 postings or more! Always have a goal in mind!!! If you can UUE encode the file when uploading, that will make it easier for the people to receive it and have it downloaded to their hard drive. That way they get a copy of the article right on their computer without hassles of viewing and then saving the article from the File menu. Don't alter the file type, leave it as an MS-DOS Text file. The best test is to be able to view this file using Microsoft's Notepad for Windows 3.x or WordPad for Windows '95. If the margins look right without making the screen slide left or right when at the ends of the sentences, you're in business! 5. If you need help uploading, simply ask the sysop of the BBS, or "POST" a message on a newsgroup asking how to post a file, tell them who your Internet provider is and PEOPLE WILL ALWAYS BE GLAD TO HELP. I would try to describe how to do it but there are simply too many internet software packages with slightly different yet relatively simple ways to post or upload a file. Just ask for help or look in the help section for 'posting'. I do know that for GNN, you simply select 'POST' then enter a catchy description under the subject box, choose 'ATTACH', selecting 'UUE' and NOT 'TXT', then choose 'Browse' to go look for the file. Find your text file CASH.TXT and click on it and choose 'OK'. Place a one line statement in the main body section of the message post screen. Something like "Download this to read how to get cash arriving in your mailbox with no paybacks!" or whatever. Just make sure it represents its true feasibility, NOT something like... "Get one million dollars flooding in your mailbox in two days!" You'll never get ANY responses! 6. And this is the step I like. JUST SIT BACK AND ENJOY LIFE BECAUSE CASH IS ON ITS THE WAY!! Expect to see a little money start to trickle in around 2 weeks, but AT ABOUT WEEKS 3 & 4, THE MONEY STORM WILL HIT YOUR MAILBOX!! All you have to do is take it out of the mailbox and try not to scream too loud (outside anyway) when you realize YOU HIT THE BIG TIME AT LAST!! 7. So go PAY OFF YOUR BILLS AND DEBTS and then get that something special you always wanted or buy that special person in your life (or the one you want in your life) a gift they'll never forget. ENJOY LIFE! 8. Now when you get low on this money supply, simply re-activate this file again; Reposting it in the old places where you originally posted and possibly some new places you now know of. Don't ever lose this file, always keep a copy at your reach for when you ever need cash. THIS IS AN INCREDIBLE TOOL THAT YOU CAN ALWAYS RE-USE TIME AND TIME AGAIN WHEN CASH IS NEEDED! ******************************************************************* ******************************************************************* THE NAMES LIST THE NAMES LIST THE NAME LIST ******************************************************************* * HONESTY IS WHAT MAKES THIS PROGRAM SUCCESSFUL!!! * * * 1. Martha Torres * 127 N. Kenwood St. * Burbank, CA 91505 * * 2. Elizabeth Porrello * P.O. Box 612 * Glenwood Landing, NY 11547-0612 * U.S.A. * * 3. Jack Pang * 1003 E. Hellman Ave. #41 * Monterey Park, CA 91755-1457 * * 4. Keith lang * 637 Cimarron Trail * Irving, TX 75063 * * 5. Lou Ehudin * 4 Trolod Ct. Apt. F1 * Owings Mills, MD 21117 * * **************************************************************** NOTE: Try to keep a list of everyone that sends you a dollar and always keep an eye on the local postings of this file...Just to make sure that everyone is playing the game fairly. You know where your name should be..... AGAIN, HONESTY IS THE BEST THING WE HAVE GOING FOR US ON THIS PLAN. -Mike Dotson, Boulder, CO *********************************************************************** By the way, if you try to deceive people by posting the messages with your name in the list and not sending the money to the people already included, you will not get much. I know someone who did this and only got about $150 (and that's after two months). Then he sent the 5 bills, people added him to their lists, and in 4-5 weeks he had over $10000! All the lists are re-distributed as soon as the money is received. End of article From owner-ageing@net.bio.net Fri Aug 09 23:00:00 1996 Path: biosci!agate!howland.erols.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!news.compuserve.com!news.production.compuserve.com!news From: Julio Karwoski <104754.445@CompuServe.COM> Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: primary cause of cell ageing Date: 10 Aug 1996 06:54:45 GMT Organization: CompuServe, Inc. (1-800-689-0736) Lines: 17 Message-ID: <4uhbnl$rl3$1@mhadf.production.compuserve.com> Xref: biosci bionet.molbio.ageing:2923 sci.life-extension:14100 I came accross some interesting articles on cell ageing regarding a new theory relating to the increased loss of methyl groups from the dna in ageing cells. Drs.M.S. Kanungo, Robin Holliday and others have postulated that ageing in somatic cells may be due to failure of maintenance of the cell. The main mechanism of cell memory is methylation. If methyl groups are lost due to cell division or otherwise, unwanted proteins will be expressed.In a completely separate study Drs. Porter and Smith and other researchers have found through cell fusion experiments that with advancing age cells express specific proteins that interfere with cell division. I was fortunate to have read these separate papers and make the link confirming the demethylation hypothesis.These studies seem to me crucial to the understanding of cell ageing.If any subscriber to this group has information on the subject and wish to share it or if anybody is interested in the specifics of the articles that I have please post. cordially: Julio Karwoski. From owner-ageing@net.bio.net Fri Aug 09 23:00:00 1996 Path: biosci!agate!howland.erols.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!news.compuserve.com!news.production.compuserve.com!news From: Julio Karwoski <104754.445@CompuServe.COM> Newsgroups: bionet.molbio.ageing Subject: Re: Different cells, Different mechanisms Date: 10 Aug 1996 05:43:39 GMT Organization: CompuServe, Inc. (1-800-689-0736) Lines: 14 Message-ID: <4uh7ib$6gi$1@mhadg.production.compuserve.com> References: <960802082758_251191294@emout15.mail.aol.com> I agree with you that cell repair mechanisms have evolved through the ages.But it is my view that we are trying to bypass the long time it takes for nature to effect a change.for this to happen we must continue to search for a primary cause of cell aging.Some bright researchers are already giving us answers.The latest news I heard were from M.S. Kanungo, and dr.R.Holliday.they see the aging process as a faillure of maintenance of the cell.(all repair cell mechanisms are not perfect therefore, there is always a small error in dna transcription and replication which is not corrected by dna polymerase or methylase.resulting in increasing demethylation of dna.this would lead to infidelity of replication and unwanted genetic expression, there is mounting evidence for this mechanism. cordially,J Karwoski From owner-ageing@net.bio.net Sat Aug 10 23:00:00 1996 Path: biosci!UNIXG.UBC.CA!browley From: browley@UNIXG.UBC.CA (Brian Rowley) Newsgroups: bionet.molbio.ageing Subject: Re: DHEA effects - could calorie restriction be a factor? Date: 11 Aug 1996 16:18:09 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 62 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <4u7g2a$8vt@nntp1.best.com> NNTP-Posting-Host: net.bio.net Yes, it is known that DHEA administration reduces intake in rodents. Another reference: Pasko LL, et al. Inhibition of proteinuria development in aging Sprague-Dawley rats and C57BL/6 mice by long-term treatment with dehydroepiandrosterone. Journal of Gerontology. 41(4):433-438, 1986. In this study, DHEA reduced food intake by about 14%. I'm sure it must depend on amount of DHEA given to the mice, though. When the mice were pair fed, the DHEA group still gained less weight than the controls, so DHEA in mice at least does still have weight loss properties not related to dietary restriction. It increases body temperature in rodents for example, so they burn off more heat. Other possible antiobesity mechanisms exist for DHEA in rodents as well. DHEA increases liver peroxisomes, which are fat-burning engines (fatty acids are broken down in peroxisomes to energy rich acetyl-CoA in a process called beta-oxidation). However, DHEA does not increase liver peroxisomes in humans the way it does in mice, and the evidence for DHEA fat loss effects in humans is totally shakey and contradictory. On 6 Aug 1996, Tim Freeman wrote: > steve@lifeco.DIALix.oz.au (Steve Chambers) wrote: > : I just came across the following: > > : We recently observed that mice fed a diet containing DHEA ate ~30% > : less food than did mice on a control diet (Weindruch, 1984). > : > : but haven't been able to find any confirmation amongst material I > : have at hand. > > Does "confirmation" mean an independent reproduction of the same > result, or an independently generated summary of the original > research? > > The full reference is: Weindruch, R., McFeeters, G., and Walford, > R.L.: Food intake reduction and immunologic alterations in mice fed > dehydroepiandrosterone. Exp Gerontol, 19:297, 1984. > > This is from the bibliography of The Retardation of Aging and Disease > by Dietary Restriction by Weindruch and Walford. The reference > appeared on page 255: > > "A caveat here is that ad lib feeding of DHEA-containing diets has > been found in other studies to reduce food intake (Nyce et al., 1984; > Weindruch et al., 1984) perhaps because DHEA-containing diets are > unpalatable (Gosnell, 1987)." > > I suppose the confirmation might be in the Nyce reference: > > Nyce, J.W., Magee, P.N., Hard, G.C., and Schwartz, A.: Inhibition of > 1, 2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by > dehydroepiandrosterone. Carcinogenesis, 5:57, 1984. > > I have not read any of these beyond The Retardation of Aging and > Disease by Dietary Restriction. > > Posted and mailed. > > Tim Freeman > > From owner-ageing@net.bio.net Sun Aug 11 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news-res.gsl.net!news.gsl.net!news.sgi.com!swrinde!cs.utexas.edu!howland.erols.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!mr.net!newshub.tc.umn.edu!fu-berlin.de!informatik.tu-muenchen.de!lrz-muenchen.de!uni-erlangen.de!winx03!news From: Gerald Muench Newsgroups: bionet.molbio.ageing Subject: Carnosine Date: 12 Aug 1996 15:09:15 GMT Organization: Theodor-Boveri-Institut fuer Biowissenschaften Lines: 16 Message-ID: <4unher$jca@winx03.informatik.uni-wuerzburg.de> NNTP-Posting-Host: wbza25.biozentrum.uni-wuerzburg.de Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.12(Macintosh; I; PPC) X-URL: news:bionet.molbio.ageing Hi, does anyone know a supplier of the anti-ageing dipeptide carnosine (in kg amounts) ? Dr. Gerald Muench Physiologische Chemie I Theodeor-Boveri-Institut fuer Biowissenschaften (Biozentrum) der Universitaet Am Hubland 97074 Wuerzburg Germany Tel.: 49 931 888-4140 FAX: 49 931 888-4150 From owner-ageing@net.bio.net Mon Aug 12 23:00:00 1996 Path: biosci!rutgers!news.sgi.com!swrinde!howland.erols.net!torn!watserv3.uwaterloo.ca!newshost.uwo.ca!usenet From: Charles Carter Newsgroups: bionet.molbio.ageing Subject: Re: a question on nanotechnology Date: 12 Aug 1996 14:22:41 GMT Organization: (UWO, London, Canada) Lines: 11 Message-ID: <4unenh$slq@falcon.ccs.uwo.ca> References: <4ua1u0$ml5@news2.h1.usa.pipeline.com> <893363732wnr@longevb.demon.co.uk> NNTP-Posting-Host: ts3-21.slip.uwo.ca Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Authenticated: pts1010@ts3-21.slip.uwo.ca X-Mailer: Mozilla 1.22 (Windows; I; 16bit) I wonder if nanotechnology research is a giant waste of time. Couldn't making customized enzymes (abzymes etc) perform the same functions as a nanoscopic 'machine' with moving parts? Once we unravel the connection between protein structure/sequence/function, enzymes could be computer designed to build macromolecular structures, carry out in-vivo repairs etc.. And this goal is only a decade or two (not a century or two) away. Chuck From owner-ageing@net.bio.net Mon Aug 12 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news.moneng.mei.com!news.ecn.bgu.edu!vixen.cso.uiuc.edu!newsfeed.internetmci.com!hunter.premier.net!uunet!in3.uu.net!psinntp!psinntp!psinntp!usenet From: jmsdean@pipeline.com Newsgroups: bionet.molbio.ageing Subject: why not just stop free radicals? Date: 13 Aug 1996 12:32:11 GMT Organization: PSINet/Pipeline USA Lines: 10 Message-ID: <4upskb$p29@news2.h1.usa.pipeline.com> NNTP-Posting-Host: 38.8.61.2 can someone please explain how free radicals are formed. there's lots of talk about the body forming free radicals when the cells use oxygen but i'm not sure how this is done. secondly, what is the chemical structure of a free radical. lastly, why is stopping free radical production, as opposed to using scaverngers like anti-oxidants, not a current possibility. luke From owner-ageing@net.bio.net Mon Aug 12 23:00:00 1996 Path: biosci!rutgers!csn!nntp-xfer-1.csn.net!magnus.acs.ohio-state.edu!freenet.columbus.oh.us!pacific.mps.ohio-state.edu!math.ohio-state.edu!usc!howland.erols.net!agate!newsgate.duke.edu!news.mathworks.com!newsfeed.internetmci.com!netnews.nwnet.net!news-hub.interserv.net!news.sprynet.com!news From: phis@sprynet.com (James Howard) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: primary cause of cell ageing Date: Tue, 13 Aug 1996 13:57:36 GMT Organization: Sprynet News Service Lines: 3 Message-ID: <4uq4kg$o6o@juliana.sprynet.com> References: <4uhbnl$rl3$1@mhadf.production.compuserve.com> NNTP-Posting-Host: dd15-115.compuserve.com Xref: biosci bionet.molbio.ageing:2932 sci.life-extension:14122 Some of your readers might want to respond to your interesting posting. Please give us your citations. From owner-ageing@net.bio.net Tue Aug 13 23:00:00 1996 Path: biosci!rutgers!csn!nntp-xfer-1.csn.net!carbon!night.primate.wisc.edu!newsspool.doit.wisc.edu!uwm.edu!news.cse.psu.edu!news.eecs.nwu.edu!newsfeed.acns.nwu.edu!news.cc.uic.edu!uicvm.uic.edu!u56375 Organization: University of Illinois at Chicago, ADN Computer Center Date: Tue, 13 Aug 1996 12:35:46 CDT From: Message-ID: <96226.123546U56375@uicvm.uic.edu> Newsgroups: bionet.molbio.ageing Subject: Senior research Specialist in Health sciences Lines: 4 Position open: Senio research specialist. Masters required. Prefer those with r esearch experience in molecular biology and immunology techniques. Position tem porary but likely to continue. Send resume to Dr. R. Krishnaraj, Geriatric Medi cine (M/C 789), University of Illinois at chicago, 840 South wood St, Chicago, IL 60612. ........... From owner-ageing@net.bio.net Tue Aug 13 23:00:00 1996 Path: biosci!rutgers!csn!nntp-xfer-1.csn.net!carbon!night.primate.wisc.edu!newsspool.doit.wisc.edu!uwm.edu!lll-winken.llnl.gov!enews.sgi.com!news.sgi.com!swrinde!howland.erols.net!psinntp!psinntp!interramp.com!ip187.urbana2.il.interramp.com!user From: coolhand@aol.com (cool hand luke) Newsgroups: bionet.molbio.ageing Subject: test--ignore Date: 13 Aug 1996 19:53:54 GMT Organization: PSI Public Usenet Link Lines: 1 Message-ID: NNTP-Posting-Host: 38.11.151.187 this is just a test From owner-ageing@net.bio.net Tue Aug 13 23:00:00 1996 Path: biosci!UNIXG.UBC.CA!browley From: browley@UNIXG.UBC.CA (Brian Rowley) Newsgroups: bionet.molbio.ageing Subject: Re: DHEA effects - could calorie restriction be a factor? Date: 13 Aug 1996 20:43:57 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 34 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <4unec2$slq@falcon.ccs.uwo.ca> NNTP-Posting-Host: net.bio.net There is a standard procedure called "pair-feeding" which is done to compensate for things which suppress appetite, for example. If a given amount of DHEA causes mice to eat 30% fewer calories, someone like Walford or Weindruch would (a) find the weight of food consumed each day by the DHEA mice (food eaten = food given - food remaining - food spilt) and (b) feed the control mice exactly the same mass of food on a day to day basis. In other words, restrict the control mice 30% also, by matching control intake to DHEA intake. Mice must be of equivalent weights and age overall. Incidentally, Arthur Schwartz didn't document appetite suppressant effects of DHEA in his initial papers--as I recall he fed the mice via a tube, so it was just pumped into their guts. -cheers On 12 Aug 1996, Charles Carter wrote: > >steve@lifeco.DIALix.oz.au (Steve Chambers) wrote: > >: I just came across the following: > > > >: We recently observed that mice fed a diet containing DHEA ate ~30% > >: less food than did mice on a control diet (Weindruch, 1984). > > > > > >Tim Freeman > > Perhaps someone should repeat the study and administer ~30% more calories > to the DHEA mice, to make sure that the anti-aging effects of DHEA can't > be attributed to the caloric restriction (as Tim pointed out). > > Chuck > > > > From owner-ageing@net.bio.net Tue Aug 13 23:00:00 1996 Path: biosci!rutgers!csn!nntp-xfer-1.csn.net!magnus.acs.ohio-state.edu!math.ohio-state.edu!uwm.edu!news-res.gsl.net!news.gsl.net!usenet.eel.ufl.edu!psgrain!quagga.ru.ac.za!und.ac.za!iafrica.com!usenet From: cryotech@iafrica.com (Michelle Olga Visser) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: primary cause of cell ageing - Julio Kaworski Date: Wed, 14 Aug 96 08:58:56 GMT Organization: Cryopreservation Technologies Lines: 36 Message-ID: NNTP-Posting-Host: 196-7-195-70.iafrica.com X-Newsreader: Quarterdeck Message Center [2.00] Xref: biosci bionet.molbio.ageing:2936 sci.life-extension:14126 Julio Kaworski wrote: >I came accross some interesting articles on cell ageing regarding >a new theory relating to the increased loss of methyl groups from >the dna in ageing cells. Drs.M.S. Kanungo, Robin Holliday and >others have postulated that ageing in somatic cells may be due to >failure of maintenance of the cell. The main mechanism of cell >memory is methylation. If methyl groups are lost due to cell >division or otherwise, unwanted proteins will be expressed.In a >completely separate study Drs. Porter and Smith and other >researchers have found through cell fusion experiments that with >advancing age cells express specific proteins that interfere with >cell division. I was fortunate to have read these separate papers >and make the link confirming the demethylation hypothesis.These >studies seem to me crucial to the understanding of cell ageing.If >any subscriber to this group has information on the subject and >wish to share it or if anybody is interested in the specifics of >the articles that I have please post. >cordially: Julio Karwoski. Mr. Kaworski, I am indeed interested in the specifics of the articles - could you please post details and publication details. Thank you, Michelle Olga Visser Head of Research, Department of Thoracic Surgery Faculty of Medicine, University of Pretoria P.O.Box 667, Pretoria, 0001 South Africa Phone : +27 12 3541677 (W) +27 12 3310701 (H) E-mail: cryotech@iafrica.com From owner-ageing@net.bio.net Tue Aug 13 23:00:00 1996 Path: biosci!rutgers!csn!nntp-xfer-1.csn.net!magnus.acs.ohio-state.edu!math.ohio-state.edu!howland.erols.net!quagga.ru.ac.za!uct.ac.za!iafrica.com!usenet From: cryotech@iafrica.com (Michelle Olga Visser) Newsgroups: bionet.molbio.ageing,sci.life-extension Subject: Re: primary cause of cell ageing - Julio Kaworski Date: Wed, 14 Aug 96 22:09:42 GMT Organization: Cryopreservation Technologies Lines: 44 Message-ID: NNTP-Posting-Host: 196-7-195-99.iafrica.com X-Newsreader: Quarterdeck Message Center [2.00] Xref: biosci bionet.molbio.ageing:2938 sci.life-extension:14133 Julio Kaworski wrote: >I came accross some interesting articles on cell ageing regarding >a new theory relating to the increased loss of methyl groups from >the dna in ageing cells. Drs.M.S. Kanungo, Robin Holliday and >others have postulated that ageing in somatic cells may be due to >failure of maintenance of the cell. The main mechanism of cell >memory is methylation. If methyl groups are lost due to cell >division or otherwise, unwanted proteins will be expressed.In a >completely separate study Drs. Porter and Smith and other >researchers have found through cell fusion experiments that with >advancing age cells express specific proteins that interfere with >cell division. I was fortunate to have read these separate papers >and make the link confirming the demethylation hypothesis.These >studies seem to me crucial to the understanding of cell ageing.If >any subscriber to this group has information on the subject and >wish to share it or if anybody is interested in the specifics of >the articles that I have please post. >cordially: Julio Karwoski. Mr. Kaworski, I am indeed interested in the specifics of the articles - could you please post details and publication details. Thank you, Michelle Olga Visser Head of Research, Department of Thoracic Surgery Faculty of Medicine, University of Pretoria P.O.Box 667, Pretoria, 0001 South Africa Phone : +27 12 3541677 (W) +27 12 3310701 (H) E-mail: cryotech@iafrica.com -- Michelle Olga Visser Head of Research, Department of Thoracic Surgery Faculty of Medicine, University of Pretoria P.O.Box 667, Pretoria, 0001 South Africa Phone : +27 12 3541677 (W) +27 12 3310701 (H) E-mail: cryotech@iafrica.com From owner-ageing@net.bio.net Wed Aug 14 23:00:00 1996 Path: biosci!rutgers!uwm.edu!newsfeed.internetmci.com!usenet.eel.ufl.edu!news.ultranet.com!d105 From: wiemanh@ma.ultranet.com (Henry M. Wieman) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: Thu, 15 Aug 96 00:34:54 GMT Organization: UltraNet Communications, Inc. Lines: 22 Message-ID: <4utv7v$j0j@decius.ultra.net> References: <4upskb$p29@news2.h1.usa.pipeline.com> NNTP-Posting-Host: d105.wor.ma.ultra.net X-Newsreader: News Xpress Version 1.0 Beta #4 In article <4upskb$p29@news2.h1.usa.pipeline.com>, jmsdean@pipeline.com wrote: >can someone please explain how free radicals are formed. there's lots of >talk about the body forming free radicals when the cells use oxygen but i'm >not sure how this is done. > >secondly, what is the chemical structure of a free radical. > >lastly, why is stopping free radical production, as opposed to using >scaverngers like anti-oxidants, not a current possibility. > >luke The best way to stop free radicals is put them back in jail where they belong :) Free radicals occur all by themselves spontaneously as it were whereever you have oxygen. Being anaerobic is the only way to stop their production. Could work. Henry M. Wieman | "Can you answer? Yes I can! wiemanh@ma.ultranet.com | But what would be the answer, Call me Hank | To the Answer Man?" | -Robert Hunter in St. Stephen From owner-ageing@net.bio.net Wed Aug 14 23:00:00 1996 Path: biosci!rutgers!uwm.edu!vixen.cso.uiuc.edu!howland.erols.net!newsserver.jvnc.net!netnews.sbphrd.com!campbejr From: campbejr@phu989.mms.sbphrd.com (John R. Campbell) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: 15 Aug 1996 15:15:31 GMT Organization: SmithKline Beecham Pharmaceuticals Research & Development Lines: 32 Message-ID: References: <4upskb$p29@news2.h1.usa.pipeline.com> Reply-To: soup@kd3bj.ampr.org NNTP-Posting-Host: phu989.sbphrd.com X-Newsreader: slrn (0.8.5) On 13 Aug 1996 12:32:11 GMT, jmsdean@pipeline.com wrote: >can someone please explain how free radicals are formed. there's lots of >talk about the body forming free radicals when the cells use oxygen but i'm >not sure how this is done. > >secondly, what is the chemical structure of a free radical. > >lastly, why is stopping free radical production, as opposed to using >scaverngers like anti-oxidants, not a current possibility. Remember now, I a *computer* tech-weenie, and I'm dredging back almost 25 years to the time I was in school, but, *IF* I recall aright, a free radical is normally a "hydroxyl". Normally, hydroxyls hang off of things like alcohol, for instance, methanol: H | H - C - O - H | H (or is it C - H - O ??? Can somebody correct this?) So much for *my* understanding. Weak, huh? -- John R. Campbell, Speaker to Machines soup@kd3bj.ampr.org Disclaimer: I'm just a consultant at the bottom of the food chain, so, if you're thinking I speak for anyone but myself, you must have more lawyers than sense. From owner-ageing@net.bio.net Wed Aug 14 23:00:00 1996 Path: biosci!rutgers!uwm.edu!spool.mu.edu!usenet.eel.ufl.edu!news.ultranet.com!d12 From: wiemanh@ma.ultranet.com (Henry M. Wieman) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: Thu, 15 Aug 96 20:33:11 GMT Organization: UltraNet Communications, Inc. Lines: 31 Message-ID: <4v05gp$7dk@decius.ultra.net> References: <4upskb$p29@news2.h1.usa.pipeline.com> NNTP-Posting-Host: d12.wor.ma.ultra.net X-Newsreader: News Xpress Version 1.0 Beta #4 In article , campbejr@phu989.mms.sbphrd.com (John R. Campbell) wrote: >On 13 Aug 1996 12:32:11 GMT, jmsdean@pipeline.com wrote: >>can someone please explain how free radicals are formed. there's lots of >>talk about the body forming free radicals when the cells use oxygen but i'm >>not sure how this is done. >> >>secondly, what is the chemical structure of a free radical. >> >>lastly, why is stopping free radical production, as opposed to using >>scaverngers like anti-oxidants, not a current possibility. > >Remember now, I a *computer* tech-weenie, and I'm dredging back almost >25 years to the time I was in school, but, *IF* I recall aright, a >free radical is normally a "hydroxyl". Normally, hydroxyls hang off > The free radicals of free radical aging are free oxygen radicals, just a charged O floating around. They are rare and hyper-reactive, hence the harm they do. There are alos hydroxyl radicals but they are different beasts. > H > | > H - C - O - H > | > H >(snip) this is methanol all right. Henry M. Wieman | "Can you answer? Yes I can! wiemanh@ma.ultranet.com | But what would be the answer, Call me Hank | To the Answer Man?" | -Robert Hunter in St. Stephen From owner-ageing@net.bio.net Fri Aug 16 23:00:00 1996 Path: biosci!rutgers!gatech!news.mindspring.com!newspump.sol.net!spool.mu.edu!news.sgi.com!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!netnews.worldnet.att.net!ix.netcom.com!news From: zentropy@ix.netcom.com(cook-stone) Newsgroups: bionet.molbio.ageing Subject: needed: info on post-op care after meniscectomy Date: 16 Aug 1996 22:47:54 GMT Organization: Netcom Lines: 16 Message-ID: <4v2tqq$je6@dfw-ixnews7.ix.netcom.com> NNTP-Posting-Host: sfo-ca16-13.ix.netcom.com X-NETCOM-Date: Fri Aug 16 5:47:54 PM CDT 1996 hello out there, i'm a 44 year old woman who will be undergoing a meniscectomy (arthroscopic surgery) of my left knee next friday and am wondering if anyone could share ANY experiences regarding post op recovery, rehabilitation, diet, exercise, etc. etc..... if you have any info concerning this, please, please write me at my e-mail address.....thanks so much! truly, j.cook, s.f. please write me directly through this e-mail address. zentropy@ix.netcom.com. thanks so much! truly, j. cook From owner-ageing@net.bio.net Fri Aug 16 23:00:00 1996 Path: biosci!rutgers!news.sgi.com!news.msfc.nasa.gov!bcm.tmc.edu!cs.utexas.edu!howland.erols.net!torn!newshost.uwo.ca!usenet From: Charles Carter Newsgroups: bionet.molbio.ageing Subject: Re: a question on nanotechnology Date: 16 Aug 1996 22:38:25 GMT Organization: (UWO, London, Canada) Lines: 46 Message-ID: <4v2t91$39q@falcon.ccs.uwo.ca> References: <4ua1u0$ml5@news2.h1.usa.pipeline.com> <893363732wnr@longevb.demon.co.uk> <4unenh$slq@falcon.ccs.uwo.ca> NNTP-Posting-Host: ts1-75.slip.uwo.ca Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Authenticated: pts1010@ts1-75.slip.uwo.ca X-Mailer: Mozilla 1.22 (Windows; I; 16bit) campbejr@phu989.mms.sbphrd.com (John R. Campbell) wrote: >He was thinking that a protein-based nanomachine would comprose the "first >generation" of nanotechnology. Consider a protozoan as rough blueprint for >a nanomachine of this ilk, and I think you'd hit it. I didn't realize that the definition of nanotechnology now includes the use of microorganisms or enzymes. Everything I know of the subject comes from a TV special I saw 5 years ago! >Enzymes, mind you, work on the scale of subsequent generations. I'm not sure what you mean by that. >Unfortunately, enzymes cannot be turned out as a generic robot and then >programmed with the work they are to do; An enzyme is programmed by it's >*shape* more than anything else. It really depends on the task you have in mind for the enzyme. Custom enzymes can be produced by making antibodies to an analog of a chemical reaction's intermediate form. In other words, if I wanted an enzyme that cleaves a dipeptide, I would find or create an organic molecule that closely resembles the structure of the dipeptide while it is in the process of hydrolysis. Then I would make antibodies to this structure and these would function just like customized enzymes. > Also, I suspect that enzymes cannot >easily manipulate things as small as single atoms, but then, I don't >know enough... Actually enzymes don't do anything except manipulate atoms. I think the biggest problem with their effectiveness as nanomachines is in their lack of'perfect' specificity for their substrate, and furthermore, a single enzyme can only accelerate a simple reaction, so many of them would have to work together under tight metabolic (or experimental) regulation. I think the nanotechnology can have a tremendous impact someday on reversing the effects of senescence, particularly if a machine can be created to 'accurately' carry out DNA recombination/repair, in vivo, in ALL somatic cells. If we can maintain the integrity of our DNA throughout our entire lives, we can eliminate a handfull of persistent aging theories in one fell swoop. -Chuck From owner-ageing@net.bio.net Sat Aug 17 23:00:00 1996 Path: biosci!rutgers!rockyd!news.sprintlink.net!news-stk-200.sprintlink.net!news-res.gsl.net!news.gsl.net!nntp04.primenet.com!nntp.primenet.com!uunet!in3.uu.net!news.compuserve.com!news.production.compuserve.com!news From: Julio Karwoski <104754.445@CompuServe.COM> Newsgroups: bionet.molbio.ageing Subject: primary cause of cell aging respons Date: 17 Aug 1996 18:53:44 GMT Organization: CompuServe, Inc. (1-800-689-0736) Lines: 22 Message-ID: <4v54fo$b3i$1@mhadf.production.compuserve.com> Michelle O. Visser (cryotech@iafrica.com) wrote: Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: Sat, 17 Aug 1996 13:22:53 -0500 Organization: Updoc Corp. Lines: 61 Message-ID: <32160DFD.7D15@hole.com> References: <4upskb$p29@news2.h1.usa.pipeline.com> Reply-To: an296216@anon.penet.fi NNTP-Posting-Host: dialup-1-42.gw.umn.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0b5 (Win95; U) To: jmsdean@pipeline.com jmsdean@pipeline.com wrote: > > can someone please explain how free radicals are formed. there's lots of > talk about the body forming free radicals when the cells use oxygen but i'm > not sure how this is done. From my college Biochem Course: When a single electron is removed from an O2 group, you get O2 -. where the . is an electron. This is known as a superoxide anion. A very very reactive molecule. this molecule wants more than anything to get another electron. and its not very fussy about where it gets it either. This anion is formed through respiration. As part of the oxidative phosphorylation cycle in the mitochondria. Look up oxidative phosphorylation in any college biochem text, or at your local library A short course: Yeast take sugar and convert it to alchol and generate 2 ATPs (adenisine triphosphate) of energy. More advanced forms (like humans) take sugar and convert it to CO2 and water yeilding 36 ATPs of energy. The extra 34 ATPs come from oxidation. Any attempt to remove free radicals at the source would reduce the amount of energy you could get from food by 94% (but on the bright side, you'd piss ethanol 8) ) > > secondly, what is the chemical structure of a free radical. > See above > lastly, why is stopping free radical production, as opposed to using > scaverngers like anti-oxidants, not a current possibility. See above Wary Wabbit PS sorry about the anon address, but I was actually on my way to another NG when I saw this question. I'd post using my real E-mail, but I don't want to connect it to my anon address. -- Kevin "Tex" Houston http://umn.edu/~hous0042/index.html Every time a third party candidate comes up, both major parties say: "You can't vote for him, you'll just be handing the election to the other guy" Well, Democrat and Republican are just two different names for the same thief, So what does it really matter? This time I'm voting Libertarian. Harry Browne for President. http://www.HarryBrowne96.org/ (800) 682-1776 From owner-ageing@net.bio.net Sat Aug 17 23:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!rutgers!rockyd!news.sprintlink.net!new-news.sprintlink.net!newsreader.sprintlink.net!news.sprintlink.net!news-ana-7.sprintlink.net!nntp04.primenet.com!nntp.primenet.com!mr.net!news-out.microserve.net!news-in.microserve.net!netaxs.com!hunter.premier.net!newsfeed.internetmci.com!in2.uu.net!hearst.acc.Virginia.EDU!murdoch!avery.med.Virginia.EDU!dsc9w From: dsc9w@avery.med.Virginia.EDU (David Cassarino) Subject: Re: why not just stop free radicals? X-Nntp-Posting-Host: avery.med.virginia.edu Message-ID: Sender: usenet@murdoch.acc.Virginia.EDU Organization: uva References: <4upskb$p29@news2.h1.usa.pipeline.com> Date: Sat, 17 Aug 1996 19:53:34 GMT Lines: 17 Free radicals are any molecules with an unpaired electron. As atoms like to have their orbitals filled with paired electrons, free rads are very reactive, being able to either donate (reduce) or abstract (oxidize) electrons from other molecs. The electron transport chain, which is necessary for aerobic metablism, generates most of the free radicals in higher organisms. It would be impossible to shut down free radical rproduction completely without disposing of aerobic metabolism, which would be fatal form most organs (ie, the brain especially is sensitve to anoxia). That's not to say we shouldn't try to offset some of the free rads' effects by consuming antioxidants... -- David S. Cassarino "The mind is not a vessel to be filled MSTP, Neuroscience 2nd Year but a fire to be kindled." UVA School of Medicine -Plutarch dsc9w@virginia.edu From owner-ageing@net.bio.net Sun Aug 18 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news.nap.net!nntp04.primenet.com!nntp.primenet.com!newspump.sol.net!news.mindspring.com!uunet!in3.uu.net!psinntp!psinntp!psinntp!usenet From: jmsdean@pipeline.com Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: 18 Aug 1996 01:53:27 GMT Organization: PSINet/Pipeline USA Lines: 13 Message-ID: <4v5t2n$pso@news2.h1.usa.pipeline.com> References: NNTP-Posting-Host: 38.8.61.2 ok, so in summary free radicals are atoms with an unpaired electron. now, and this is just a shot in the dark, what if you made a lot of electrons available to all atoms, or in the specific area of the electron transport chain where most free radicals are made? flood those areas with extra electrons so that the free radical doesn't pull it off of a healthy atom from a healthy tissue. can't the free radical just pick up an electron by itself, or does it absolutely have to pull it from a somatic cell? i'll call this the electron flood hypothesis. luke From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!rutgers!mcrcr6!cmcl2!news.sprintlink.net!news-stk-200.sprintlink.net!news-res.gsl.net!news.gsl.net!hunter.premier.net!newsfeed.internetmci.com!news.compuserve.com!news.production.compuserve.com!news Newsgroups: bionet.biology.cardiovascular,bionet.biophysics,bionet.general,bionet.molbio.ageing,bionet.neuroscience Subject: ACTIVITY METER FOR LAB ANIMALS Message-ID: <4vf3o2$mi8$1@mhafn.production.compuserve.com> From: JAN CZEKAJEWSKI <75144.2413@CompuServe.COM> Date: 21 Aug 1996 13:42:26 GMT Organization: Columbus Instruments Lines: 20 Xref: biosci bionet.biology.cardiovascular:1137 bionet.biophysics:2236 bionet.general:23020 bionet.molbio.ageing:2951 bionet.neuroscience:15385 The behavioral change in response to drug in laboratory animals can be assessed partly by monitoring through the "Auto-Track" animal Activity Meter. The system has an interface to IBMPC/AT compatible computers that provides complete automation of data collection. It also provides 'zoning' capability and monitors subject entries and latencies for up to multiple user-defined cage areas. The following features are very unique for Auto-Track. 1. Monitors upto 16 cages simultaneously. 2. Distance travelled and pattern of movement data. 3. Separates ambulatory activity from total activity. 4. Provides zone monitoring capability. 5. Can be optionally equipped for animal rotation monitor. 6. Computer storage of processed and raw data. 7. 15 infra-red photocell per axis. 8. Primary vertical sensor for rearing activity and secondary vertical sensor is for jumping. If you need further information, please e-mail your postal address. I will be happy to mail you all information. From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!news.alaska.edu!newsfeed.acns.nwu.edu!news.luc.edu!uchinews!uwvax!uwm.edu!cs.utexas.edu!howland.erols.net!newsfeed.internetmci.com!uuneo.neosoft.com!winnie-ppp-l5.NeoSoft.com!pproctor From: pproctor@neosoft.com (Peter H. Proctor) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: Wed, 21 Aug 1996 10:58:21 UNDEFINED Organization: NeoSoft, Inc. Lines: 19 Message-ID: References: <4upskb$p29@news2.h1.usa.pipeline.com> NNTP-Posting-Host: 206.109.10.236 X-Newsreader: Trumpet for Windows [Version 1.0 Rev B final beta #1] In article <4upskb$p29@news2.h1.usa.pipeline.com> jmsdean@pipeline.com writes: >From: jmsdean@pipeline.com >Subject: why not just stop free radicals? >Date: 13 Aug 1996 12:32:11 GMT >can someone please explain how free radicals are formed. there's lots of >talk about the body forming free radicals when the cells use oxygen but i'm >not sure how this is done. > >secondly, what is the chemical structure of a free radical. > >lastly, why is stopping free radical production, as opposed to using >scaverngers like anti-oxidants, not a current possibility. See ( he says modestly ), P Proctor, Free Radicals and Human Disease, in CRC handbood of Free Radicals and Antioxidants, Vol 1 (1989) p 209. For a review. This is a pretty complicated subject. Dr. P From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!newsfeed.internetmci.com!realtime.net!news From: mbrophy@cwconnect.ca Newsgroups: bionet.molbio.ageing Subject: Re:Gerontological Research Date: 22 Aug 1996 05:46:29 GMT Organization: Deja News Usenet Posting Service Lines: 41 Message-ID: <840690500.5821@dejanews.com> NNTP-Posting-Host: bastion.dejanews.com X-RTcode: 5f92910f32353db1cc1bf41a X-Originating-IP-addr: 207.61.147.104 (ts-nbayp04.cwconnect.ca) sender@forecasts.com wrote: >Anyone has information on the best Web site(s) and newsgroups that deal with Aging (or Ageing) and Gerontology or gerontological research? Here are a few of my favourites and these of course will lead you to even more Centre for Studies in Aging http://library.utoronto.ca/www/aging/depthome.html http://www.geriatricvideo.com/ Huffington Centre on Aging http://www.bcm.tmc.edu/hcoa/ Directory of Web and Gopher Aging sites http://www.aoa.dhhs.gov/aoa/webres/craig.htm http://www.seniornet.com http://www.premier.net/~gero/geropsyc.html Internet resources related Dementia and Alzheimer Disease: Ottawa-Carleton Alzheimer Society http://www.ncf.carleton.ca/freeport/socialservices/alzheimer/menu US Alzheimer Organization http://www.alz.org Dementia Web http://dementia.ion.ac.uk Michael Rebhans Resource Page Page (excellent !!) htttp://www.uni-hohenheim.de/~rebhan/ ----------------------------------------------------------------------- This article was posted to Usenet via the Posting Service at Deja News: http://www.dejanews.com/ [Search, Post, and Read Usenet News!] From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!cam-news-hub1.bbnplanet.com!nntp-hub2.barrnet.net!venus.sun.com!rutgers!uwm.edu!homer.alpha.net!news.ultranet.com!d101 From: wiemanh@ma.ultranet.com (Henry M. Wieman) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: Mon, 19 Aug 96 20:44:20 GMT Organization: UltraNet Communications, Inc. Lines: 23 Message-ID: <4vanms$rmg@decius.ultra.net> References: <4v5t2n$pso@news2.h1.usa.pipeline.com> NNTP-Posting-Host: d101.wor.ma.ultra.net X-Newsreader: News Xpress Version 1.0 Beta #4 In article <4v5t2n$pso@news2.h1.usa.pipeline.com>, jmsdean@pipeline.com wrote: >ok, so in summary free radicals are atoms with an unpaired electron. > >now, and this is just a shot in the dark, what if you made a lot of >electrons available to all atoms, or in the specific area of the electron >transport chain where most free radicals are made? flood those areas with >extra electrons so that the free radical doesn't pull it off of a healthy >atom from a healthy tissue. > >can't the free radical just pick up an electron by itself, or does it >absolutely have to pull it from a somatic cell? i'll call this the >electron flood hypothesis. Well Luke old buddy, You could provide electrons two ways: chemically and physically. Chemically would be putting an electron donor in the soup. You call that a (Tah-Dah) antioxidant! Lots of folks doing that. Physically would be (Tah Dah) Frankenstein's monster!! Electricity in human flesh as a long term kind of thing seems to have too many side effects. Henry M. Wieman | "Can you answer? Yes I can! wiemanh@ma.ultranet.com | But what would be the answer, Call me Hank | To the Answer Man?" | -Robert Hunter in St. Stephen From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!daresbury!nntp-trd.UNINETT.no!online.no!Norway.EU.net!EU.net!howland.erols.net!newsserver.jvnc.net!netnews.sbphrd.com!campbejr From: campbejr@phu989.mms.sbphrd.com (John R. Campbell) Newsgroups: bionet.molbio.ageing Subject: Re: a question on nanotechnology Date: 15 Aug 1996 15:12:13 GMT Organization: SmithKline Beecham Pharmaceuticals Research & Development Lines: 29 Message-ID: References: <4ua1u0$ml5@news2.h1.usa.pipeline.com> <893363732wnr@longevb.demon.co.uk> <4unenh$slq@falcon.ccs.uwo.ca> Reply-To: soup@kd3bj.ampr.org NNTP-Posting-Host: phu989.sbphrd.com X-Newsreader: slrn (0.8.5) On 12 Aug 1996 14:22:41 GMT, Charles Carter wrote: >I wonder if nanotechnology research is a giant waste of time. Couldn't >making customized enzymes (abzymes etc) perform the same functions as a >nanoscopic 'machine' with moving parts? Once we unravel the connection >between protein structure/sequence/function, enzymes could be computer >designed to build macromolecular structures, carry out in-vivo repairs >etc.. And this goal is only a decade or two (not a century or two) away. From Drexler's "Engines of Creation" (available on the net at http://reality.sgi.com/whitaker/EnginesOfCreation He was thinking that a protein-based nanomachine would comprose the "first generation" of nanotechnology. Consider a protozoan as rough blueprint for a nanomachine of this ilk, and I think you'd hit it. Enzymes, mind you, work on the scale of subsequent generations. Unfortunately, enzymes cannot be turned out as a generic robot and then programmed with the work they are to do; An enzyme is programmed by it's *shape* more than anything else. Also, I suspect that enzymes cannot easily manipulate things as small as single atoms, but then, I don't know enough... -- John R. Campbell, Speaker to Machines soup@kd3bj.ampr.org Disclaimer: I'm just a consultant at the bottom of the food chain, so, if you're thinking I speak for anyone but myself, you must have more lawyers than sense. From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!rutgers!uwm.edu!cs.utexas.edu!howland.erols.net!cam-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!newsfeed.internetmci.com!in2.uu.net!nntp.inet.fi!news.funet.fi!news.cs.hut.fi!news.clinet.fi!usenet From: narkia@clinet.fi (Matti Narkia) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: Thu, 22 Aug 1996 17:00:23 GMT Organization: Clinet, Espoo, Finland. Lines: 16 Message-ID: <4vh0e1$e1r@news.clinet.fi> References: <4upskb$p29@news2.h1.usa.pipeline.com> NNTP-Posting-Host: narkia.clinet.fi X-Newsreader: Forte Free Agent 1.0.82 jmsdean@pipeline.com wrote: >lastly, why is stopping free radical production, as opposed to using >scaverngers like anti-oxidants, not a current possibility. > I'm not an expert in these matters, but according to my understanding a certain amount of free radicals is useful and necessary for the human body. Some cells in the immune system for example use free radicals to destroy bacteria, viruses and cancer cells. It's the uncontrolled overproduction of free radicals which is the problem. --- Matti Narkia Helsinki, Finland From owner-ageing@net.bio.net Wed Aug 21 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news-res.gsl.net!news.gsl.net!hunter.premier.net!newsfeed.internetmci.com!in3.uu.net!EU.net!Norway.EU.net!nntp.uio.no!nntp.uib.no!nntp-bergen.UNINETT.no!nntp-trd.UNINETT.no!daresbury!bioftp.unibas.ch!infobiogen.fr!jussieu.fr!saphir.jouy.inra.fr!usenet From: Anis Limami Newsgroups: bionet.molbio.ageing Subject: INFORMATION NEEDED - Plant Antioxidants- Date: 22 Aug 1996 11:25:00 GMT Organization: INRA Lines: 15 Message-ID: <4vhg2c$bj3@saphir.jouy.inra.fr> NNTP-Posting-Host: saphir.jouy.inra.fr Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; 68K) X-URL: news:bionet.molbio.ageing INFORMATION NEEDED I am looking for all kind of information(s) that one would be kind to bring me about - plant crude extracts or plant purified molecules which have antioxidant properties - or at least name(s) of plants or plant species which are known to contain high amounts of antioxidants This kind of stuff is used in food industry, called Natural antioxidant, for instance rosemary plants (Romarin in french). Many thanks in advance Anis Limami email : limami@versailles.inra.fr From owner-ageing@net.bio.net Fri Aug 23 23:00:00 1996 Path: biosci!agate!spool.mu.edu!uwm.edu!news.sol.net!newspump.sol.net!nntp0.mindspring.com!news.mindspring.com!psinntp!psinntp!psinntp!usenet From: yo_doc@usa.pipeline.com(Richard A. Lockshin) Newsgroups: bionet.cellbiol,bionet.celegans,bionet.immunology,bionet.neuroscience,bionet.cellbiol,bionet.molbio.ageing,bionet.general,bionet.drosophila Subject: FALL MEETING, MECH. OF CELL DEATH,CELL DEATH SOC. NYC Date: 23 Aug 1996 20:22:38 GMT Organization: Pipeline Lines: 116 Message-ID: <4vl3ue$ldf@news1.t1.usa.pipeline.com> NNTP-Posting-Host: 38.8.137.4 X-PipeUser: yo_doc X-PipeHub: usa.pipeline.com X-PipeGCOS: (Richard A. Lockshin) X-Newsreader: Pipeline v3.5.0 Xref: biosci bionet.cellbiol:5327 bionet.celegans:1031 bionet.immunology:9620 bionet.neuroscience:15424 bionet.molbio.ageing:2958 bionet.general:23051 bionet.drosophila:2360 FALL MEETING Mechanisms of Cell Death CELL DEATH SOCIETY The Death Poets' Society) Date: Saturday, October 12, 1996 8:45AM-6:00 PM Queens College of C.U.N.Y. Music Building Lefrak Hall Flushing, Queens, N.Y. Speakers: Session I Opening Remarks Chair: Zahra Zakeri Samuil Umanski LXR Biotechnology, Inc., Richmond, CA Relationship between cell death and proliferation. Jean-Claude Ameisen Universite de Paris, Paris, France On the evolutionary origin of programmed cell death and its role in host- pathogen interactions Coffee Break Session II Chair: Raymond Birge Michael Hengartner Cold Spring Harbor Labs, Cold Spring Harbor, NY Programmed cell death in C. elegans Barbara A. Osborne University of Massachusetts, Amherst Regulation of apoptosis in the thymus Gabriel Nunez University of Michigan, Ann Arbor Regulation of Cell Death by Bcl-2 Gene Family Lunch Session III Chair: Richard Lang David Vaux Walter & Elisa Hall Institute, Australia Using cell death inhibitors to understand pathways of apoptosis Dale Bredesen La Jolla Cancer Research Foundation, La Jolla, CA Thanatopsis: Principles emerging from the study of neural cell death. Coffee Break Session IV Chair: Richard Lockshin Martin Tenniswood W. Alton Jones Cell Science Center, Lake Placid NY Is there a causative link between apoptosis and metastasis in glandular tissues? Mauro Piacentini Universita degli Studi di Roma "Tor Vergata", Rome, Italy "Tissue" transglutaminase: A multifunctional element of the physiological cell death program Closing Remarks: Richard Lockshin Organizers: Zahra Zakeri, Queens College, Ray Birge, Rockefeller Organizing Committee: Richard Lang, NYU; Richard Lockshin, St. John's U., Michael Hengartner, Cold Spring Harbor Labs. FEES: BEFORE OCTOBER 1, 1996, INCLUDES LUNCH POSTDOCTORAL FELLOWS AND STUDENTS $25 OTHERS $50 ON-SITE REGISTRATION, ALL $75 MAKE CHECKS PAYABLE TO QUEENS COLLEGE FOUNDATION (CELL DEATH CLUB). SEND TO: MS UMA NARAYAN, QUEENS COLLEGE, REMSEN HALL 125, FLUSHING, NY 11367- 1597. SORRY, NO CREDIT CARDS REGISTRATION IS LIMITED TO 400. Contact: Zahra Zakeri Department of Biology Queens College and Graduate Center of CUNY Flushing, NY 11367 Tel: 718: 997-3417 Fax: 718: 997-3445 Email: zhz$biol@qc1.qc.edu OUR CLUB The formation of a Metropolitan Area Cell Death Society (Club) at Rockefeller University, with meetings each month, has been a great success. Attendance hovers around 60-90 people, coming from several institutions, and a mailing list of over 200, from several countries. If you are interested in getting details of the monthly meeting, and having others know about your interest in cell death, please contact us. In addition, it would be helpful if you let others know about us and ask them to get this information to us. FOR INSTRUCTIONS, DIRECTIONS, HOTEL INSTRUCTIONS, ETC. CONTACT ZAHRA ZAKERI AT ABOVE ADDRESSES. (OR REPLY TO ME AT lockshin@stjohns.edu. Our newsreader was unhappy today.) From owner-ageing@net.bio.net Fri Aug 23 23:00:00 1996 Path: biosci!agate!howland.erols.net!cam-news-hub1.bbnplanet.com!cpk-news-feed2.bbnplanet.com!cpk-news-hub1.bbnplanet.com!newsfeed.internetmci.com!netnews.nwnet.net!nntp.umt.edu!selway.umt.edu!robert From: robert@selway.umt.edu (Robert K Knight) Newsgroups: bionet.molbio.ageing Subject: Re: why not just stop free radicals? Date: 24 Aug 1996 06:26:31 GMT Organization: University of Montana, Missoula Lines: 39 Message-ID: <4vm7an$bfd@server.umt.edu> References: <4upskb$p29@news2.h1.usa.pipeline.com> NNTP-Posting-Host: selway.umt.edu In article , Peter H. Proctor wrote: >In article <4upskb$p29@news2.h1.usa.pipeline.com> jmsdean@pipeline.com writes: >>From: jmsdean@pipeline.com >>Subject: why not just stop free radicals? >>Date: 13 Aug 1996 12:32:11 GMT > >>can someone please explain how free radicals are formed. there's lots of >>talk about the body forming free radicals when the cells use oxygen but i'm >>not sure how this is done. >> >>secondly, what is the chemical structure of a free radical. >> >>lastly, why is stopping free radical production, as opposed to using >>scaverngers like anti-oxidants, not a current possibility. > >See ( he says modestly ), P Proctor, Free Radicals and Human Disease, in CRC >handbood of Free Radicals and Antioxidants, Vol 1 (1989) p 209. For a review. >This is a pretty complicated subject. > >Dr. P Never-the-less, I'll give it a shot in as few words as possible... 'Tis the nature of electrons in chemical systems -- read 'atoms and molecules', to travel in pairs. If, for some reason, an electron frees itself of it's paired existance, it snatches up an electron from a nearby molecule. Then, that molecule snatches up an electron, and the process continues until two unshared electrons meet (an unlikely event) or until an electron is donated from a special species of molecule which forms 'stable free radicals'... this species of molecule is known as an antioxidant. The problem with this random swapping of electrons is that a whole host of chemical bonds are formed and broken in the process. Where the molecules involved are DNA, you have mutation and often cancer. Where the molecules involved are cellular constituants, you often have mechanical failure of the cell or cells. This is a _very_ simplistic explanation and I'd encourage you to look up the above-mentioned literature. Good Luck. R. From owner-ageing@net.bio.net Mon Aug 26 23:00:00 1996 Path: biosci!agate!spool.mu.edu!uwm.edu!cs.utexas.edu!howland.erols.net!cam-news-hub1.bbnplanet.com!uunet!in2.uu.net!netnews.worldnet.att.net!ix.netcom.com!news From: jjberman@ix.netcom.com(Jules Berman ) Newsgroups: bionet.molbio.ageing Subject: Free Disease Biology Search Engine Date: 27 Aug 1996 00:48:53 GMT Organization: Netcom Lines: 28 Message-ID: <4vtgll$8f6@dfw-ixnews4.ix.netcom.com> NNTP-Posting-Host: bal-md5-20.ix.netcom.com X-NETCOM-Date: Mon Aug 26 7:48:53 PM CDT 1996 Pathology Informatics, Inc., invites health professionals to visit our new web site: http://www.pathinfo.com/ This is the location of our Lightning Hypertext of Disease search engine, that performs simple Boolean searches on a database composed of more than 21,000 information packets related to pathology and disease biology. All searches are free, and, at this time, there is no limit to the number of permitted searches. Readers of the bionet.molbio.ageing newsgroup might be interested in searches using the term: aging (NOT ageing) or the term apoptosis Most medical phrases are included in the electronic index. Warning: The search engine is written as a highly technical source of information designed for health professionals and biologists, and laymen will not find it a helpful source of information. Sincerely, Jules Berman, President, Pathology Informatics, Inc. From owner-ageing@net.bio.net Mon Aug 26 23:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!agate!howland.erols.net!cam-news-hub1.bbnplanet.com!uunet!in2.uu.net!shore!mv!mv.mv.com!katel From: katel@mv.mv.com (Katharine Lindner) Subject: Re: why not just stop free radicals? Message-ID: Organization: MV Communications, Inc. Date: Tue, 27 Aug 1996 05:28:57 GMT References: <4upskb$p29@news2.h1.usa.pipeline.com> <4vm7an$bfd@server.umt.edu> X-Nntp-Posting-Host: mv.mv.com Lines: 7 I've heard that certain mosses live high in the Andes and other mountains and have to deal with strong UV radiation and dessication? Do they have anything to tell us about protection from free radicals? Have any researchers looked into them? Kathy From owner-ageing@net.bio.net Sat Aug 31 23:00:00 1996 Newsgroups: bionet.metabolic-reg,bionet.microbiology,bionet.molbio.ageing,bionet.molbio.gene-linkage,bionet.molbio.yeast Path: biosci!agate!howland.erols.net!newsfeed.internetmci.com!demos!satisfy.kiae.su!glukr!info.elvisti.kiev.ua!mailhost.ic-chernobyl.kiev.ua!news-server From: "Marina U. 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