From owner-ageing@net.bio.net Tue Oct 01 23:00:00 1996 Path: biosci!daresbury!not-for-mail From: rattan@kemi.aau.dk (Suresh Rattan) Newsgroups: bionet.molbio.ageing Subject: Natural kinetin Date: 2 Oct 1996 09:50:25 +0100 Lines: 38 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <52tach$ch7@mserv1.dl.ac.uk> Original-To: ageing@dl.ac.uk During the last few years, we have reported the anti-ageing effects of a plant hormone kinetin on human cells and on Drosophila. As regards kinetin itself, it has been believed that this compound does not exist naturally and is formed only as an artifact of DNA mis-handling. We have now found out that kinetin does exist in nature, and that it may be a kind of natural defense molecules against oxidative damage. Here is the abstract of our recently published paper: Abstract: In contrast to the current view that kinetin (N6-furfuryladenine) is an unnatural and synthetic compound, we have detected it in commercially available DNA, in freshly extracted cellular DNA from human cells and in plant cell extracts by two independent methods. First, we discovered that N6-furfuryladenine has electrochemical properties that can be applied for monitoring this modified base by HPLC/UV/EC method. Second, we have confirmed electrochemical assignments by mass-spectrometric analysis. A pathway of kinetin formation is proposed in which the formation of furfural by oxidative damage of the deoxyribose moiety of DNA is followed by its reaction with adenine residues to form N6-furfuryladenine. Since this modification can lead to mutations, the odd DNA base has to be removed by repair enzymes. complete reference: Evidence for the presence of kinetin in DNA and cell extracts Jan Barciszewski, Gunhild E. Siboska, Bent O. Pedersen, Brian F.C. Clark and Suresh I.S. Rattan FEBS Letters, 393: 197-200, 1996 (the latest issue). Dr. Suresh I.S. Rattan, PhD; DSc Laboratory of Cellular Ageing Department of Chemistry Aarhus University DK-8000 Aarhus-C, Denmark. (Phone: +45 8942 3956; Fax: +45 8619 6199) From owner-ageing@net.bio.net Tue Oct 01 23:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!daresbury!nntp-trd.UNINETT.no!sn.no!Oslo2.Norway.EU.net!Norway.EU.net!nntp.uio.no!www.nntp.primenet.com!nntp.primenet.com!howland.erols.net!netcom.com!vunovick From: vunovick@netcom.com (Varda Ullman Novick) Subject: Alzheimer's caregivers project Message-ID: Organization: NETCOM On-line Communication Services (408 261-4700 guest) X-Newsreader: TIN [version 1.2 PL1] Date: Wed, 2 Oct 1996 20:45:28 GMT Lines: 18 Sender: vunovick@netcom9.netcom.com A major healthcare organization has asked us to survey caregivers of people with Alzheimer's disease. We will pay $15 to those who complete a 20-item questionnaire by Saturday, October 5. All information is strictly confidential: no one's name will be revealed to anyone, including the healthcare organization, nor will it be placed on any mailing lists. To receive a copy of the questionnaire, write to me at: vunovick@netcom.com Varda Ullman Novick Impulse Research Corp. 8829 National Blvd. Suite 1006 Culver City, CA 90232 310-559-6892 From owner-ageing@net.bio.net Wed Oct 02 23:00:00 1996 Path: biosci!agate!spool.mu.edu!newspump.sol.net!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.molbio.ageing Subject: APOPTOSIS/PROG.CELL DEATH WEB PAGE Date: Thu, 03 Oct 1996 02:10:53 GMT Organization: MindSpring Enterprises, Inc. Lines: 6 Message-ID: <52v8gl$h2l@camel3.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip202.an10.new-york4.ny.psi.net X-Server-Date: 3 Oct 1996 02:30:45 GMT X-Newsreader: Forte Free Agent 1.0.82 lockshin@stjohns.edu lockshin@mindspring.com check out Apoptosis/Programmed Cell Death Web Page http://rdz.stjohns.edu/~lockshin/index.html From owner-ageing@net.bio.net Wed Oct 02 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.erols.net!newspump.sol.net!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.molbio.ageing Subject: APOPTOSIS/PROG.CELL DEATH WEB PAGE Date: Thu, 03 Oct 1996 02:11:37 GMT Organization: MindSpring Enterprises, Inc. Lines: 12 Message-ID: <52v8i2$h2l@camel3.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip202.an10.new-york4.ny.psi.net X-Server-Date: 3 Oct 1996 02:31:30 GMT X-Newsreader: Forte Free Agent 1.0.82 [SORRY, I HIT THE WRONG KEY AND SENT AN EMPTY FILE] Announcing the Apoptosis/Programmed Cell Death Web Page: http://rdz.stjohns.edu/~lockshin/index.html presented by The Cell Death Society and St. John's University This will be a cooperative page.The basic structure is available, but submissions, comments, and suggestions will be welcome. Check it out or email me at the address below. lockshin@stjohns.edu lockshin@mindspring.com check out Apoptosis/Programmed Cell Death Web Page http://rdz.stjohns.edu/~lockshin/index.html From owner-ageing@net.bio.net Wed Oct 02 23:00:00 1996 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.ageing Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 3 Oct 1996 02:00:41 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 239 Sender: daemon@net.bio.net Distribution: world Message-ID: <199610030900.CAA26533@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From owner-ageing@net.bio.net Thu Oct 03 23:00:00 1996 Path: biosci!biosci!not-for-mail From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.neuroscience,bionet.cellbiol,bionet.drosophila,bionet.general,bionet.immunology,bionet.molbio.ageing,bionet.celegans Subject: Apoptosis meeting Oct 12 last call - cdmeet4.txt (0/1) Date: 3 Oct 1996 19:39:19 -0700 Organization: MindSpring Enterprises, Inc. Lines: 7 Sender: daemon@net.bio.net Distribution: world Message-ID: <52v8ol$h2l@camel3.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: net.bio.net Xref: biosci bionet.neuroscience:15997 bionet.cellbiol:5593 bionet.drosophila:2493 bionet.general:23461 bionet.immunology:9897 bionet.molbio.ageing:2993 bionet.celegans:1084 A few places are still available for the following: lockshin@stjohns.edu lockshin@mindspring.com check out Apoptosis/Programmed Cell Death Web Page http://rdz.stjohns.edu/~lockshin/index.html From owner-ageing@net.bio.net Thu Oct 03 23:00:00 1996 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!news.sgi.com!www.nntp.primenet.com!nntp.primenet.com!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.molbio.ageing Subject: CELL DEATH SYMPOSIUM LAST CALL Date: Fri, 04 Oct 1996 14:25:49 GMT Organization: MindSpring Enterprises, Inc. Lines: 108 Message-ID: <5336ub$2te@camel1.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip119.an10.new-york4.ny.psi.net X-Server-Date: 4 Oct 1996 14:28:27 GMT X-Newsreader: Forte Free Agent 1.0.82 [TEXT INCLUDED THIS TIME] From: "Richard A. Lockshin" Organization: St. John's University FALL MEETING Mechanisms of Cell Death LAST CALL CELL DEATH SOCIETY The Death Poets' Society) Date: Saturday, October 12, 1996 8:45AM-6:00 PM Queens College of C.U.N.Y. Music Building, Lefrak Hall Flushing, Queens, N.Y. Speakers: Session I Opening Remarks Chair: Zahra Zakeri Samuil Umanski LXR Biotechnology, Inc., Richmond, CA Relationship between cell death and proliferation. Arturo Zychlinsky Skirball Inst., NYU Apoptosis as a trigger of inflammation in Shigella infection Coffee Break Session II Chair: Raymond Birge Michael Hengartner Cold Spring Harbor Labs, Cold Spring Harbor, NY Programmed cell death in C. elegans Barbara A. Osborne University of Massachusetts, Amherst Regulation of apoptosis in the thymus Gabriel Nunez University of Michigan, Ann Arbor Regulation of Cell Death by Bcl-2 Gene Family Lunch Session III Chair: Richard Lang David Vaux Walter & Elisa Hall Institute, Australia Using cell death inhibitors to understand pathways of apoptosis Dale Bredesen La Jolla Cancer Research Foundation, La Jolla, CA Thanatopsis: Principles emerging from the study of neural cell death. Coffee Break Session IV Chair: Richard Lockshin Martin Tenniswood W. Alton Jones Cell Science Center, Lake Placid NY Is there a causative link between apoptosis and metastasis in glandular tissues? Mauro Piacentini Università degli Studi di Roma "Tor Vergata", Rome, Italy "Tissue" transglutaminase: A multifunctional element of the physiological cell death program Closing Remarks: Richard Lockshin Organizers: Zahra Zakeri, Queens College, Ray Birge, Rockefeller Organizing Committee: Richard Lang, NYU; Richard Lockshin, St. John's U., Michael Hengartner, Cold Spring Harbor Labs. FEES: BEFORE OCTOBER 1, 1996, INCLUDES LUNCH POSTDOCTORAL FELLOWS AND STUDENTS $25 OTHERS $50 ON-SITE REGISTRATION, ALL $75 MAKE CHECKS PAYABLE TO QUEENS COLLEGE FOUNDATION (CELL DEATH CLUB). SEND TO: MS UMA NARAYAN, QUEENS COLLEGE, REMSEN HALL 125, FLUSHING, NY 11367- 1597. SORRY, NO CREDIT CARDS REGISTRATION IS LIMITED TO 400. Contact: Zahra Zakeri Department of Biology Queens College and Graduate Center of CUNY Flushing, NY 11367 Tel: 718: 997-3417 Fax: 718: 997-3445 Email: zhz$biol@qc1.qc.edu FOR INSTRUCTIONS, DIRECTIONS, HOTEL INSTRUCTIONS, ETC. CONTACT ZAHRA ZAKERI AT ABOVE ADDRESSES. Richard A. Lockshin (lockshin@mindspring.com;lockshin@sjumusic.stjohns.edu) From owner-ageing@net.bio.net Fri Oct 04 23:00:00 1996 Path: biosci!agate!howland.erols.net!vixen.cso.uiuc.edu!uwm.edu!lll-winken.llnl.gov!enews.sgi.com!news.sgi.com!news.msfc.nasa.gov!newsfeed.internetmci.com!news.datalytics.com!news.sprintlink.net!news-chi-8.sprintlink.net!gol2!user From: joels@gol.com (Joel Sassone) Newsgroups: bionet.molbio.ageing Subject: Re: Update on Negligible Senescence in Long-Lived Fishes Date: Sun, 06 Oct 1996 05:29:26 +0900 Organization: Himself Lines: 8 Message-ID: References: <199607160208.WAA29424@mail-e2b-service.gnn.com> NNTP-Posting-Host: yok1-36.gol.com Thank you for the fascinating description of long-lived lobsters. Ah, to be reborn a thousand years from now, when we understand these processes... Joel From owner-ageing@net.bio.net Sun Oct 06 23:00:00 1996 Path: biosci!agate!howland.erols.net!news.mathworks.com!uunet!news-in2.uu.net!demos!dnews-server From: "Aleksandr Yu. Maslov" Newsgroups: bionet.general,bionet.jobs.wanted,bionet.molbio.ageing,sci.research,sci.research.careers,sci.research.postdoc Subject: Seeking German biomedicals for collaboration Date: 7 Oct 1996 12:53:02 +0400 Organization: Voronezh State Medical Institute Lines: 31 Sender: news-server@news.demos.su Distribution: world Message-ID: Reply-To: maslov@vgmi.voronezh.su NNTP-Posting-Host: root@news.demos.su X-mailer: BML [MS/DOS Beauty Mail v1.36h] X-Return-Path: news.demos.su!kremvax.demos.su!ic.vrn.ru!vgmi!vgmi.voronezh.su!uucp Xref: biosci bionet.general:23511 bionet.jobs.wanted:8365 bionet.molbio.ageing:2997 sci.research:9926 sci.research.careers:12612 sci.research.postdoc:5201 Dear Sir/Madame, I am a Russian citizen and currently working in Voronezh State Medical Academy on Dep. of Medical Biology and Genetics as a assistant. I have the Ph.D. degree in biology. Area of my research are: regeneration, morphogenesis, regulation of cell proliferation. I am looking for contacts with German scientists for long collabora- tion in this area and to able to accept me as Research Fellow for carrying out the concrete investigation. I am going to send applications form to Deutscher Akademischer Austauschdienst (DAAD) for receiving of one year fellowship (1997/1998), therefore I want to find accepting University in advance. The Aim of the investigation: - study of local (tissue level) and central mechanisms (hypotalamus) of regulation of morphogenetical processes and regeneration; - detection agents (messengers) which influence on this processes on different levels of organization. The object of the investigation: - regenerating liver of adult rats; - liver of newborn rats. Unfortunately, I have not possibility to research this problem on molbio level. If You need more information I am ready to provide one. Thank You for this courtesy, faithfully Yours, --- Dr. Aleksandr Yu. Maslov, Ph.D. Department of Biology, Voronezh State Medical Academy 10- Studencheskaya str., Voronezh, 394622, Russia E- mail: maslov@vgmi.voronezh.su From owner-ageing@net.bio.net Mon Oct 07 23:00:00 1996 Path: biosci!agate!howland.erols.net!news.sgi.com!esiee.fr!jussieu.fr!oleane!in2p3.fr!swidir.switch.ch!01-newsfeed.univie.ac.at!news.cesnet.cz!rhino.cis.vutbr.cz!risc.upol.cz!decsys.vsb.cz!newsmast From: Respondby@Mail.com (LSAT Productions) Newsgroups: bionet.molbio.ageing Subject: !!!!!!!!!!! FREE INTERNET ACCESS !!!!!!!!!!! Date: Fri, 04 Oct 1996 08:23:35 GMT Organization: Home.com Lines: 74 Message-ID: <532hau$73v@decsys.vsb.cz> Reply-To: Respondby@Mail.com NNTP-Posting-Host: cust104.max22.los-angeles.ca.ms.uu.net X-Newsreader: Forte Agent NS#8 1.0.82 !!!!!!!!!!! FREE INTERNET ACCESS !!!!!!!!!!! NEVER EVER pay for Internet Access AGAIN!!! E-V-E-R! 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Please make checks payable to -> LSAT From owner-ageing@net.bio.net Mon Oct 07 23:00:00 1996 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.erols.net!cs.utexas.edu!news.tamu.edu!news From: Dawn Capp Newsgroups: bionet.molbio.ageing Subject: Free WEB service to research authors Date: Tue, 08 Oct 1996 09:24:53 -0500 Organization: Texas A&M University Lines: 6 Message-ID: <325A6435.38B2@tam2000.tamu.edu> NNTP-Posting-Host: ppp1b-12.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) Capp Scientific offers a free WEB service to research authors who have difficulty getting their work published in scientific journals. Go To http://members.aol.com/CappSci for more information. From owner-ageing@net.bio.net Wed Oct 09 23:00:00 1996 Path: biosci!agate!howland.erols.net!newsfeed.internetmci.com!news.nuri.net!news From: nj_paik@www.cheiljedang.com (Lee Seong-hak) Newsgroups: bionet.molbio.ageing Subject: Re: Alzheimer's caregivers project Date: Thu, 10 Oct 1996 12:53:02 GMT Organization: HanNuri Internet Service Lines: 2 Message-ID: <53iur4$8f1@cham.nuri.net> References: NNTP-Posting-Host: 203.248.118.249 X-Newsreader: Forte Free Agent 1.0.82 From owner-ageing@net.bio.net Thu Oct 10 23:00:00 1996 Path: biosci!rutgers!uwm.edu!nntp.primenet.com!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.molbio.ageing Subject: cell death mtg directions Date: Fri, 11 Oct 1996 22:03:05 GMT Organization: MindSpring Enterprises, Inc. Lines: 5 Message-ID: <53mgbq$1cs@camel0.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip38.an6.new-york4.ny.psi.net X-Server-Date: 11 Oct 1996 22:05:46 GMT X-Newsreader: Forte Free Agent 1.0.82 If you did not get directions to the campus, see web site http://rdz.stjohns.edu/~lockshin/index.html Richard A. Lockshin (lockshin@mindspring.com;lockshin@sjumusic.stjohns.edu) From owner-ageing@net.bio.net Mon Oct 14 23:00:00 1996 Path: biosci!rutgers!gatech!csulb.edu!news.uoregon.edu!news-peer.gsl.net!news.gsl.net!newspump.sol.net!news.mindspring.com!uunet!in3.uu.net!delphi.com!usenet From: Lou Pagnucco Newsgroups: bionet.molbio.ageing Subject: Detroit Area Presentation by Dr. M. Fossel on Telomere Theory of Aging Date: Mon, 14 Oct 96 23:23:57 -0500 Organization: Delphi (info@delphi.com email, 800-695-4005 voice) Lines: 30 Message-ID: NNTP-Posting-Host: bos1d.delphi.com Dr. Richard Fossel will discuss the telomere theory of aging at 1:00 PM on Sunday, October 20 at the Borders Book Store in Novi, Michigan. Dr. Fossel is the author of the very popular recently published book, "Reversing Human Aging". Telomeres are gene sequences which terminate chromosomes. For most cell types, telomeres are reduced in length every cell division and may be the "clock" which determines each cell's biological age. Telomeres appear to be centrally involved in the regulation of cell growth, differentiation and senescence. Future telemere based therapies show promise for arresting cancer growth and possibly rejuvenating old cells. Dr. Fossel earned his Ph.D. in Neurobiology and his M.D. at Stanford University. A recipient of a National Science Fellowship, Dr. Fossel began his work on aging while still in medical school. He has taught biology, medicine, ethics and aging at several universities and is currently Professor of Clinical Medicine at Michigan State University. Dr. Fossel will be available to sign his book after his presentation. Novi Borders is located in the strip mall south of I96 (just south of the Twelve Oaks Mall) about one mile west of the I275 interchange and just off of Novi road. From owner-ageing@net.bio.net Mon Oct 14 23:00:00 1996 Path: biosci!rutgers!gatech!www.nntp.primenet.com!nntp.primenet.com!howland.erols.net!cs.utexas.edu!news.tamu.edu!news From: The Informant Newsgroups: bionet.molbio.ageing Subject: Re: possible explanation for evolutionary/natural selection of aging process Date: Tue, 15 Oct 1996 14:05:58 -0500 Organization: Texas A&M University, College Station, Texas Lines: 2 Message-ID: <3263E096.1060@worldnet.att.net> References: <53v264$bmn@sjx-ixn6.ix.netcom.com> NNTP-Posting-Host: ppp17-06.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) To: Brandon Smith The main theory, I believe, is that aging may have developed to combat cancer. From owner-ageing@net.bio.net Mon Oct 14 23:00:00 1996 Path: biosci!IUNHAW1.IUN.INDIANA.EDU!TSTABLER From: TSTABLER@IUNHAW1.IUN.INDIANA.EDU ("Tim Stabler") Newsgroups: bionet.molbio.ageing Subject: Meeting Date: 15 Oct 1996 09:18:22 -0700 Organization: Indiana University Northwest Lines: 28 Sender: daemon@net.bio.net Distribution: world Message-ID: <4C1F009B7@iunhaw1.iun.indiana.edu> Reply-To: tstabler@iunhaw1.iun.indiana.edu NNTP-Posting-Host: net.bio.net I would like to announce that next year, June 14-18, the Society for In Vitro Biology will be holding its Congrtess at the Renaissance Hotel in Washington, D.C. Various symposia and workshops are planned, some of which directly interface with this group. If you would like further information, please Email me your snail- mail address and I will get it to you immediately. Or, if you are into the Web, you can look up "SIVB" on your net search. Especially, if you are using Netscape Navigator and the "Infoseek" area. There you will find all sorts of information about the group, past meetings and plans for this meeting. If you wish, you might be able to be a poster presenter or speaker. I can get you that information also. There will be an exhibit area from various companies. If you Email me, please note that in my address it is "iunhaw(one)" and not an "L" there. I have had several folks make this mistake. Thanks for you time. Timothy A. Stabler, Ph.D. Department of Biology Indiana University Northwest Gary, IN 46408 (219)980-6718 FAX: (219)980-7125 From owner-ageing@net.bio.net Mon Oct 14 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!swrinde!howland.erols.net!EU.net!uunet!in1.uu.net!news.accessone.com!robertm From: robertm@nicom.com (Robert?) Newsgroups: bionet.molbio.ageing Subject: Water Filters Date: Tue, 15 Oct 96 22:32:09 GMT Organization: AccessOne Lines: 16 Message-ID: <3264114e.0@news.daka.com> NNTP-Posting-Host: news.daka.com X-Newsreader: News Xpress 2.0 Beta #2 Maybe its time to think about having clean water in the your home. Several types of systems are inexpensive and available for the home and business. Counter top, under counter systems, shower systems, in line systems, and whole house or business systems. Think of the last time you could say the water you drink, wash your body in, cook with, and serve your children, was free of hard minerals, bacteria, pesticides, metals, odors, and sediments of all kinds? Give your self the opportunity to purchase an EPA OSHA certified product that will give you the chance to say that today. If you are concerned for your health, the taste of your food, or the quality of your washing results, you can receive information to help you make an intelligent decision your body will never regret. You are 70% water. Might be nice to get some clean stuff inside? Email > shannye@juno.com From owner-ageing@net.bio.net Mon Oct 14 23:00:00 1996 Path: biosci!EROLS.COM!zeke2 From: zeke2@EROLS.COM (zeke shaub) Newsgroups: bionet.molbio.ageing Subject: aging and genes Date: 15 Oct 1996 14:58:35 -0700 Organization: Preferred Company Lines: 3 Sender: daemon@net.bio.net Distribution: world Message-ID: <27EE8087.358@erols.com> NNTP-Posting-Host: net.bio.net How long will it take until the research on aging by all of the biotechnology firms, be available to the public, in the way of drugs, or genetic therapy? From owner-ageing@net.bio.net Mon Oct 14 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!swrinde!news-peer.gsl.net!news.gsl.net!ix.netcom.com!news From: bcs2@ix.netcom.com(Brandon Smith) Newsgroups: bionet.molbio.ageing Subject: possible explanation for evolutionary/natural selection of aging process Date: 15 Oct 1996 03:59:00 GMT Organization: Netcom Lines: 18 Message-ID: <53v264$bmn@sjx-ixn6.ix.netcom.com> NNTP-Posting-Host: mol-il1-26.ix.netcom.com X-NETCOM-Date: Mon Oct 14 8:59:00 PM PDT 1996 Does anyone have any ideas regarding possible theories about evolution/natural selection in reference to the aging process? Perhaps the governing of cell divisions is caused to program the species for approximate maximum survivability with regards to needed food and other resouces along with environmentals, and hence physical size is governed accordingly? Also, perhaps certain species needed physical size regulation for reproductive compatibility among each individual species? Perhaps not with certain systems such as fish implement, but certainly with mammals, for example, which might explain that some aquatic creatures seem to have little or no size regulation or aging, such as lobsters, while others such as ourselves do.. Also, what's the latest regarding the 50 divisions observations? I'm not learned in such fields, but am curious to hear some thoughts out there as to other possible ev./nat.sel. theories on what might cause genetic, cellular nucleic governing? I have already heard of the consumption of repeating dna at the ends, which appears to possibly play a role, as animals which do not clearly demonstrate aging appear to have enzymes supporting the replenishment of such repeaters.. From owner-ageing@net.bio.net Tue Oct 15 23:00:00 1996 Path: biosci!agate!spool.mu.edu!howland.erols.net!cs.utexas.edu!news.tamu.edu!news From: "Dawn C." Newsgroups: bionet.molbio.ageing Subject: Re: aging and genes Date: Wed, 16 Oct 1996 07:13:39 -0500 Organization: Texas A&M University, College of Medicine Lines: 6 Message-ID: <3264D173.6DF7@tam2000.tamu.edu> References: <27EE8087.358@erols.com> NNTP-Posting-Host: ppp17-19.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) To: zeke shaub Don't hold your breath. Usu research is made available through journal publications.. but actual gene therapy - that won't be happening for a long, long time. You know how the scientific community is about human and gene therapy. -Dawn- From owner-ageing@net.bio.net Fri Oct 18 23:00:00 1996 Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!news.mel.connect.com.au!news.mel.aone.net.au!usenet From: "Stewart Washer" Newsgroups: bionet.molbio.ageing Subject: Human Growth Hormone Question Date: 19 Oct 1996 03:07:20 GMT Organization: Biowest Australia Lines: 6 Message-ID: <01bbbd6a$52fb3b00$0fbf0ccb@stewart> NNTP-Posting-Host: d15-1.cpe.perth.aone.net.au Mime-Version: 1.0 Content-Type: text/plain; charset=ISO-8859-1 Content-Transfer-Encoding: 7bit X-Newsreader: Microsoft Internet News 4.70.1141 Can anyone inform me on the latest details regarding Human growth hormone and it's effects on aging ? Regards, Stewart From owner-ageing@net.bio.net Mon Oct 21 23:00:00 1996 Path: biosci!agate!howland.erols.net!newsfeed.internetmci.com!in1.uu.net!munnari.OZ.AU!news.uwa.edu.au!newsman.murdoch.edu.au!vetmac3.murdoch.edu.au!user From: cummins@central.murdoch.edu.au (Jim Cummins) Newsgroups: bionet.molbio.ageing Subject: Mitochondrial DNA fragmentation Date: Tue, 22 Oct 1996 15:03:40 +0800 Organization: Murdoch University Lines: 11 Message-ID: NNTP-Posting-Host: vetmac3.murdoch.edu.au Hayakawa et al (BBRC 226: 369-377) provide powerful new evidence supporting the mitochondrial DNA/redox mechanism of ageing. Using a total-deletion PCR system they demonstrate up to 358 different deletion types including minicircles lacking replication origins ( do they replicate and if so, how?). The age-related increase in the total types of fragmented mtDNA correlates closely with general oxidative DNA damage as measured by deoxynucleoside accumulation. Amazingly, in the oldes individuals wild-type mtDNA was down to 11% of the total. -- URL http://numbat.murdoch.edu.au/spermatology/spermhp.html From owner-ageing@net.bio.net Mon Oct 21 23:00:00 1996 Path: biosci!daresbury!nntp-trd.UNINETT.no!nntp.uio.no!www.nntp.primenet.com!nntp.primenet.com!howland.erols.net!newsfeed.internetmci.com!demos!dnews-server From: "Aleksandr Yu. Maslov" Newsgroups: bionet.general,bionet.jobs.wanted,bionet.molbio.ageing,sci.research,sci.research.careers,sci.research.postdoc Subject: Suche nach einem Platz fuer die Durchfuehrung eines Vertiefungsstudiums in Deutchland Date: 22 Oct 1996 12:20:49 +0400 Organization: Voronezh State Medical Institute Lines: 34 Sender: news-server@news.demos.su Distribution: world Message-ID: References: <0.3630.844436244@news.demos.su> Reply-To: maslov@vgmi.voronezh.su NNTP-Posting-Host: root@news.demos.su X-mailer: BML [MS/DOS Beauty Mail v1.36h] X-Return-Path: news.demos.su!kremvax.demos.su!ic.vrn.ru!vgmi!vgmi.voronezh.su!uucp Xref: biosci bionet.general:23716 bionet.jobs.wanted:8630 bionet.molbio.ageing:3011 sci.research:10019 sci.research.careers:12823 sci.research.postdoc:5273 Sehr geehrte Damen und Herren, Ich bin russischer Staatsbuerger und arbeite gegenwaertig als Assistent an der Medizinischen Staatsakademie Voronezh Abt. Medizinische Biologie und Genetik. Ich habe den Ph.D.Abschluss. Meine Forschungsgebiete sind: Regeneration, Morphogenesis, Regulation der Zellausbreitung. Ich suche nach Kontakten mit deutschen Wissenschaftlern fuer eine laengerfristige Zusammenarbeit auf diesen Gebieten, und um faehig zu sein, als Forschungspartner fuer die Ausfuehrung konkreter Untersuchungen anerkannt zu werden. Ich werde Bewerbungsformulare an den Deutschen Akademischen Austauschdienst (DAAD) schicken betreff des Erhalts eines Einjahresforschungsstipendiums (1997/98), wofuer ich eine mich zulassende Universitaet im voraus finden moechte. Das Untersuchungsziel: - Studium des lokalen (Gewebeebene) und zentralen Mechanismen (Hypothalamus) der Regulation von morphogenetischen Prozessen und der Regeneration; - Feststellungsdrogen (Boten), die diese Prozesse auf verschiedenen Organisationsstufen beeinflussen. Das Untersuchungsobjekt: - Regeneration der Leber von erwachsenen Ratten - Leber von neugeborenen Ratten Leider habe ich keine Moeglichkeit, dieses Problem auf molbio-Ebene zu loesen. Falls sie mehr Informationen benoetigen, werde ich sie Ihnen gerne zur Verfuegung stellen. Ich danke Ihnen fuer Ihre Gefaelligkeit und verbleibe Mit freundlichen Gruessen --- Dr. Aleksandr Yu. Maslov, Ph.D. Department of Biology, Voronezh State Medical Academy 10- Studencheskaya str., Voronezh, 394622, Russia E- mail: maslov@vgmi.voronezh.su From owner-ageing@net.bio.net Mon Oct 21 23:00:00 1996 Path: biosci!daresbury!not-for-mail From: jcoward@mail.islandnet.com (Jim Coward) Newsgroups: bionet.molbio.ageing Subject: ITCH'96 Date: 22 Oct 1996 23:06:12 +0100 Lines: 19 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <54jggk$17a@mserv1.dl.ac.uk> X-Sender: jcoward@mail.islandnet.com Original-To: itch@hsd.uvic.ca ITCH'96 - INFORMATION TECHNOLOGY IN COMMUNITY HEALTH - Time to register! "Appropriate Systems / Appropriate Decisions" as a theme has probably never been more important than it is in today's economically challenged and changing times. Many papers will be presented on issues from Community and Hospital Health Systems, Internet Applications, Standards, Physician Resource Systems, to Public Health Education Approaches...just to name a few. Don't miss the pre-conference workshops and tutorials...and don't miss beautiful Victoria, Canada...hundreds already registered...there IS still time. Check out the website: http://www.hsd.uvic.ca/HIS/ITCH/ITCH.htm Jim Coward, CHE (Coordinator, BC Health Information Standards Council) Organizing Committee - ITCH'96 Information Technology in Community Health ITCH'96 WEBPAGE: http://www.hsd.uvic.ca/HIS/ITCH/ITCH.htm Phone (250)952-1838 FAX (250) 658-6394 Cell Phone (250) 881-2537 Jim's Website: http://www.islandnet.com/~jcoward/homepage.htm From owner-ageing@net.bio.net Tue Oct 22 23:00:00 1996 Path: biosci!daresbury!not-for-mail From: "Joerg M. Sigle" Newsgroups: bionet.molbio.ageing Subject: aids@rutgers.edu;aids_intl@rutgers.edu;fxx1@1lmuacad;fxx1@lmuac ad;bro@huey.met.fsu.edu;uj21@dkauni2.bitnet;rbenoit@count.ab.umd.edu;VMa mied-l@1.MCGILL.CA;anchodd@cc.utas.edu.au;anest-l@ubvm.cc.buffalo.edu Date: 23 Oct 1996 21:59:26 +0100 Lines: 177 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <54m0ve$p0i@mserv1.dl.ac.uk> X-Sender: s_jsigle@popserv1.rz.uni-ulm.de Original-To: ageing@dl.ac.uk Hello! I write this message to inform you about the concept of a Quality-of-Life-Recorder, an instrument that allows totally computer-illiterate people (patients of all ages) to answer electronic questionnaires without any training. I write this message to a number of different people. Thus, on the one hand, it has to stay small, but on the other hand, I have to include some background information - please read (scan) this mail completely and have a look at: http://www.uni-ulm.de/~s_jsigle There you can get further information, a literature reference and a software package including documentation. This mail contains the following paragraphs: - BACKGROUND - WHAT I WOULD LIKE TO HAPPEN - HOW CAN IT HAPPEN - WHERE IS THE SOFTWARE? - HARDWARE AND OTHER CONSIDERATIONS - COPYRIGHT NOTICE - AND THEN? ............................................................................... ----------- BACKGROUND: ----------- A lot of research work has been published in the field of quality of life. A patient's (multi-dimensional) "quality of life" can be described by results from questionnaires asking for his subjective perception of his condition. Supplementing the gained duration of survival, quality of life is another parameter which informs about the utility of medical measures and which can support decision making. However, it is not yet collected routinely, among other reasons, because of practical problems inferred by the use of paper questionnaires. As a medical student working in the field of patients' quality of life, in 1993 I designed the original Quality-of-Life-Recorder: a PC-based system which allowed patients of all ages to fill in an electronic of a quality of life questionnaire without any training, without any problems. E.g., in one study in a university outpatient clinic, more than 1100 patients used the system during a four weeks period in 1993 (compliance >98,5%, questionnaire completeness >99,96%, data representing 94,8% of the patients who visited the clinic during the study period). Since then, thousands of patients have used the system in different settings. Because there were some limits in the original system (mainly the necessity of a special hardware device), I continued its development. ---------------------------- WHAT I WOULD LIKE TO HAPPEN: ---------------------------- If the concept of the Quality-of-Life-Recorder will spread, future medical studies can collect data of high quality, which will be immediately available, easily exchangeable and which can be used for tasks like meta-analysis of many studies without any difficulties. By means of the QL-Recorder, quality of life data can be collected as a measure of the outcome of different therapy strategies, even in routine clinical and practice work. The resulting data base can support further therapy development and decision making. (Naturally, the use of this tool is not limited to the medical (patient-) field, but it can be used anywhere where questionnaire data have to be processed.) ------------------ HOW CAN IT HAPPEN? ------------------ Recently, I have continued the development of the Quality-of-Life-Recorder. The resulting software supports almost any available questionnaire, any input device (depending on your budget and on your taste: mouse, trackball, digitizer, touch-screen, pen-computer), colors, different fonts and digitized sound (talking questionnaire) on any Microsoft Windows computer. Like the original Quality-of-Life-Recorder, it alternatively supports a solution which does not require a patient to read questions from a screen at all. Collected data can be transferred to any computer platform and to any statistical, mathematical or database software. An integrated graphic editor allows the user to design electronic versions from the paper questionnaires he already has got. Because this tool makes it easy to let a paper questionnaire go electronic, and because - depending on the hardware you use - its handling is easiest for a patient, it can be used even in small studies or during questionnaire development. The software was developed without any funding from public or private sponsors so far, because I think that it might be useful for the medical community. I want to provide the software as shareware. This means, that you can try it for free, and you can become a registered user if you want to use it after an evaluation period. IMPORTANT: if you definitely don't have any funds, you can still register - FOR FREE! ---------------------- WHERE IS THE SOFTWARE? ---------------------- You can get further information and download the software from: http://www.uni-ulm.de/~s_jsigle You will find a self-extracting archive, the software has an automatic setup routine. So you won't have any trouble in installing it. Its documentation comes inside a Windows-Help-File, including some images and further background information. Don't be afraid: It will be easy to download, taking about 7..15 minutes through a 28.800 Baud modem connection, 2..5 minutes throug an ISDN link, or seconds if you have a faster connection. It really might be interesting for you to have a look at it, if you work in the medical field. ... Enjoy! --------------------------------- HARDWARE AND OTHER CONSIDERATIONS --------------------------------- If you need more information about suitable hardware, if you're looking for other people using the Quality-of-Life-Recorder, or if you need support to set up a project, please feel free to contact me. ---------------- COPYRIGHT NOTICE ---------------- Before you use any copyrighted questionnaire, e.g. in a study, you have to ensure that its respective copyright owners grant you the right to use it. The fact that you might have available a file which would enable you to collect data corresponding to a certain questionnaire's definitions and concepts, needs not automatically entitle you to do so, just the same way that the fact, that you have a printed copy of a questionnaire, does not automatically entitle you to use it. If you don't know where to get information about copyright owners of a questionnaire, it might be a good start to consult the literature reference which you find at my web site. From myself, you can only get the right to use my software - which, however should support almost any available questionnaire. Before you use my software, please read the respective paragraphs of the help file which accompanies it. --------- AND THEN? --------- Of course, I would appreciate any feedback - positive or negative - from you. Certainly, I would like to answer any questions of yours, either regarding the Quality-of-Life-Recorder or general questions around the topic. Finally, I would like to ask you to hand on this message to your colleagues, to WWW-server-administrators or to any other interested person. Thank you for reading the whole thing! Greetings... Joerg Sigle. From owner-ageing@net.bio.net Sun Oct 27 22:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.erols.net!newspump.sol.net!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.celegans,bionet.cellbiol,bionet.drosophila,bionet.general,bionet.immunology,bionet.molbio.ageing,bionet.neuroscience Subject: NYC Cell Death Club Meeting & Announcement Date: Mon, 28 Oct 1996 22:52:43 GMT Organization: MindSpring Enterprises, Inc. Lines: 44 Message-ID: <553dlm$6ve@camel0.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip214.an9.new-york4.ny.psi.net X-Server-Date: 28 Oct 1996 22:55:50 GMT X-Newsreader: Forte Free Agent 1.0.82 Xref: biosci bionet.celegans:1124 bionet.cellbiol:5808 bionet.drosophila:2565 bionet.general:23806 bionet.immunology:10092 bionet.molbio.ageing:3017 bionet.neuroscience:16443 CELL DEATH SOCIETY (The Death Poets' Society) November meeting Date: Thursday, November 7, 1996 Time: 6:00-6:30 PM Pizza, 6:30-8:00 PM Talks & Discussion Place: Rockefeller Univ., 1230 York Ave. Weiss Research Bldg Room 301 SEE INSTRUCTIONS AND NEW PLANS BELOW Speakers: 1. Yael Goldberg, Rockefeller: Aspirin-like drugs induce apoptosis: Molecular mechanisms and signficance for cancer prevention. 2. Luis Benitez-Bribiesca (Instituto Mexicano del Seguro Social, Mexico City): Single cell gel electrophoresis: Is it useful for assessing apoptosis? NEW PLANS: We are working to send this by email and announcement on our web page (http://rdz.stjohns.edu/~lockshin/index.html-- check it out and make suggestions) rather than by fax and this route. If you do not receive email announcements and would like them, please reply to this (delete the message) so that we can get your correct address. DRIVING AND ATTENDANCE INSTRUCTIONS Free parking after 5 PM at 66th St. & York Ave. Please car pool since parking space is limited. RSVP: To help us plan for the pizza and the number of attendees, we ask that you call Dr. Zakeri's lab (718-997-3429) and let them know of the number of people coming for the pizza, talk, & if you need parking. RSVP by Wednesday, November 6, 1996 Organizers: Zahra Zakeri, fax 718-997-3445, phone 718-997-3417 Raymond Birge fax 212-327-7943, phone 212-327-7412 SPONSORED BY: Oncor Appligene Cell Death and Differentiation Richard A. Lockshin (lockshin@mindspring.com;lockshin@sjumusic.stjohns.edu) From owner-ageing@net.bio.net Mon Oct 28 22:00:00 1996 Path: biosci!agate!howland.erols.net!newsfeed.internetmci.com!in1.uu.net!news-m01.ny.us.ibm.net!news-s01.ca.us.ibm.net!not-for-mail From: "Darryl R. Lum" Newsgroups: bionet.molbio.ageing,sci.med.nutrition,sci.med.pharmacy Subject: Pikamilone Date: 29 Oct 1996 00:36:38 GMT Lines: 53 Message-ID: <01bbc531$7bb5c500$6acb48a6@drlum> NNTP-Posting-Host: slip166-72-203-106.hi.us.ibm.net Mime-Version: 1.0 Content-Type: text/plain; charset=ISO-8859-1 Content-Transfer-Encoding: 7bit X-Newsreader: Microsoft Internet News 4.70.1155 Xref: biosci bionet.molbio.ageing:3018 sci.med.nutrition:52443 sci.med.pharmacy:35432 I recently received the following information on Pikamilone and would like feedback on the validity of the assertions. I have done a search on the internet Web and Usenet for "Pikamilone" and have found 0 hits. ---- BEGIN ASSERTIONS Pikamilone is an amazing powerful compound with antioxidant properties. It has been available in some parts of the world for over 25 years. Its primary use has been to both treat and combat brain ageing and associated disorders. At lower dosage, 50mg TID will achieve a tranquilizing effect. Increasing dosage to 100mg TID will bring about a stimulation effect and increase endurance. The effects of Pikamilone are felt quickly, most people will notice an impact within one hour. The body usually retains Pikamilone for up to six hours. Pikamilone crosses the blood brain barrier easily, which is why the results are normally experienced so rapidly. Pikamilone is a cleverly combined combination of GABA and Niacin, the way the two items are chemically bonded means the manufacturing process is formidable and that is why we have taken a great deal of both care and time in introduction of this exciting new product. Studies prove it to be more stimulating than Piracetam and to have a more pronounced effect than Vinpocetine. Other studies have shown Pikamilone has the ability to boost blood circulation, and blood supply to the brain, in a manner far superior to the results achieved with either Hydergine or Xanthinol Nicotinate. Toxicity is extremely low. LD50 is over 10 grams per kilo in mice. Pikamilone has shown no carcinogenic properties. ---- END ASSERTIONS There were 15 references to journal articles, but 14 of those references were from USSR journals and primarily from the late seventies to early eighties. Any information/opinions regarding Pikamilone are welcome! -- Darryl R. Lum drlum@ibm.net From owner-ageing@net.bio.net Tue Oct 29 22:00:00 1996 Path: biosci!agate!howland.erols.net!news.sprintlink.net!news-peer.sprintlink.net!uunet!in1.uu.net!fu-berlin.de!cystein.chemie.fu-berlin.DE!a_kowald From: a_kowald@chemie.fu-berlin.de (Axel Kowald) Newsgroups: bionet.molbio.ageing Subject: Removal of age pigment ? Date: 30 Oct 1996 09:19:02 GMT Organization: Kristallographic Institute FU Berlin Lines: 9 Distribution: world Message-ID: <5576i6$8cd@fu-berlin.de> NNTP-Posting-Host: cystein.chemie.fu-berlin.de (160.45.24.35) NNTP-Posting-User: a_kowald X-Access: 16 17 19 Hi there I heard somewhere that it is possible to remove age pigment (lipofuscin) from the skin by using some kind of vitamin E or vitamin A containing ointment. Unfortunately I forgot the details. Does any one know more about this ? Many thanks Axel Kowald From owner-ageing@net.bio.net Tue Oct 29 22:00:00 1996 Path: biosci!UNIXG.UBC.CA!browley From: browley@UNIXG.UBC.CA (Brian Rowley) Newsgroups: bionet.molbio.ageing Subject: Re: Removal of age pigment ? Date: 30 Oct 1996 09:36:03 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 20 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <5576i6$8cd@fu-berlin.de> NNTP-Posting-Host: net.bio.net A lot of people say that centrophenoxine removes lipofuscin from skin and nerve cells due to its antioxidant properties. However, I've see two studies, one in primate and one in rodent retinal neuronal (I think) cells showing no effect on lipofuscin content whatsoever. Still, people claim that lipofuscin removal occurs with centrophenoxine. Maybe other studies suggest it does. I realize I'm off topic, by the way :-> On 30 Oct 1996, Axel Kowald wrote: > Hi there > > I heard somewhere that it is possible to remove age pigment (lipofuscin) from the > skin by using some kind of vitamin E or vitamin A containing ointment. > Unfortunately I forgot the details. Does any one know more about this ? > > Many thanks > > Axel Kowald > >