From owner-ageing@net.bio.net Mon Dec 02 22:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!bunyip.cc.uq.oz.au!marlin.jcu.edu.au!crab.jcu.edu.au!sci-ajcc From: Aaron Clarke Subject: Theories on Ageing Content-Type: TEXT/PLAIN; charset=US-ASCII Message-ID: Sender: news@marlin.jcu.edu.au (USENET News System) Organization: James Cook University Mime-Version: 1.0 Date: Tue, 3 Dec 1996 15:25:16 +1000 Lines: 11 Hi my name is Aaron, I would like to know the current theories regarding cellular ageing and the cellular mechanism involved in this condition. If you would suggest journals in this field and websites, that would be greatly appreciated. If you are a researcher in this field I would also like to know any work your research group has published. I'm a biochemistry and chemistry student at James Cook University, who is interested in all kinds of disorders and conditions. Bye for now, Aaron From owner-ageing@net.bio.net Mon Dec 02 22:00:00 1996 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.ageing Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 3 Dec 1996 02:00:48 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 239 Sender: daemon@net.bio.net Distribution: world Message-ID: <199612031000.CAA26695@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. 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For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From owner-ageing@net.bio.net Mon Dec 02 22:00:00 1996 Path: biosci!ihnp4.ucsd.edu!swrinde!cs.utexas.edu!news.tamu.edu!news From: Dawn Newsgroups: bionet.molbio.ageing Subject: Re: Theories on Ageing Date: Tue, 03 Dec 1996 08:50:35 -0600 Organization: Texas A&M University, College of Medicine Lines: 11 Message-ID: <32A43E3B.E09@bigfoot.com> References: Reply-To: dawnc@bigfoot.com NNTP-Posting-Host: ppp12-10.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) To: Aaron Clarke There are several web sites and journals that publish research/info on ageing. http://www.hookup.net/mall/aging/agesit59.html http://www.mednwh.unimelb.edu.au/ http://www.apopnet.com/apoptosis/ I am a grad student in the field and have written a senior thesis on ageing that is being published by Pantomime. -Dawn- From owner-ageing@net.bio.net Tue Dec 03 22:00:00 1996 Path: biosci!ihnp4.ucsd.edu!swrinde!howland.erols.net!feed1.news.erols.com!news.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.mindspring.com!usenet From: fcgolf Newsgroups: bionet.molbio.ageing Subject: Ampakine CX 516 Mind mender Date: Wed, 04 Dec 1996 14:45:54 -0600 Organization: MindSpring Enterprises Lines: 8 Message-ID: <32A5E2EC.53@tomnet.com> NNTP-Posting-Host: user-168-121-70-87.dialup.mindspring.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Server-Date: 4 Dec 1996 20:43:37 GMT X-Mailer: Mozilla 3.01Gold (Macintosh; I; 68K) Reported in news and at national meeting of The Society for Neuroscience, this drug acts to increase memory capability in all groups. Results in older men "striking" per G. Lynch, U. Cal. at Irvine. Does any one know the chemical description of this drug? What stage of availability has it reached? If it works, what will it do the present social structure of 'out with the old in with the new'? A sizeable population of old but wise people with the minds of a 35 year olds would be ???????. From owner-ageing@net.bio.net Tue Dec 03 22:00:00 1996 Path: biosci!ihnp4.ucsd.edu!swrinde!cs.utexas.edu!news.tamu.edu!news From: Dawn Newsgroups: bionet.molbio.ageing Subject: Re: hayflick numbers Date: Tue, 03 Dec 1996 22:25:45 -0600 Organization: Texas A&M University, College of Medicine Lines: 4 Message-ID: <32A4FD49.E9@bigfoot.com> References: <4sk9nk$a89@news2.h1.usa.pipeline.com> <581ep8$prt@charlie.lif.icnet.uk> Reply-To: dawnc@bigfoot.com NNTP-Posting-Host: ppp19-09.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) To: Robert Boyd When a cell reaches it Hayflick limit, it stops dividing (cellular senescence) and usually eventually undergoes apoptosis. -Dawn- From owner-ageing@net.bio.net Tue Dec 03 22:00:00 1996 Path: biosci!daresbury!lyra.csx.cam.ac.uk!warwick!nntpfeed.doc.ic.ac.uk!sunsite.doc.ic.ac.uk!charlie.lif.icnet.uk!europa.lif.icnet.uk!boydr From: boydr@europa.lif.icnet.uk (Robert Boyd) Newsgroups: bionet.molbio.ageing Subject: Re: hayflick numbers Date: 3 Dec 1996 14:51:20 GMT Organization: Imperial Cancer Research Fund Lines: 13 Message-ID: <581ep8$prt@charlie.lif.icnet.uk> References: <4sk9nk$a89@news2.h1.usa.pipeline.com> NNTP-Posting-Host: europa.lif.icnet.uk X-Newsreader: TIN [version 1.2 PL2] jmsdean@pipeline.com wrote: : some of you have seen my posts. i'm just a lay person with a large degree : of curiosity in cellular ageing. i'm also just getting started. i went : through a lot of Medline abstracts today so i'm learning. : : my question is: is the Hayflick number always 50 +/- 10 ? : or is it different for each type of cell? : what happens when a cell reaches its : hayflick number? : : any replies are much appreciated. : : luke From owner-ageing@net.bio.net Wed Dec 04 22:00:00 1996 Path: biosci!agate!howland.erols.net!news.bbnplanet.com!cam-news-hub1.bbnplanet.com!uunet!in1.uu.net!204.253.208.40!insync!Gamma.RU!srcc!news.uni-stuttgart.de!news.urz.uni-heidelberg.de!usenet From: un691cs@genius.embnet.dkfz-heidelberg.de (slavemaster) Newsgroups: bionet.molbio.ageing Subject: Re: Theories on Ageing Date: 5 Dec 1996 17:05:05 GMT Organization: not the pizza hut delivery sevrice Lines: 28 Message-ID: <586vc1$7k2@sun0.urz.uni-heidelberg.de> References: <32A43E3B.E09@bigfoot.com> NNTP-Posting-Host: pc7.ana.uni-heidelberg.de Mime-Version: 1.0 Content-Type: Text/Plain; charset=US-ASCII X-Newsreader: WinVN 0.99.7 In article <32A43E3B.E09@bigfoot.com>, dawnc@bigfoot.com says... >There are several web sites and journals that publish research/info on >ageing. >http://www.hookup.net/mall/aging/agesit59.html >http://www.mednwh.unimelb.edu.au/ >http://www.apopnet.com/apoptosis/ >I am a grad student in the field and have written a senior thesis on >ageing that is being published by Pantomime. >-Dawn- Pantomime ? isn't that a rather akward way to bring your data to the attention of the scientific world ? Original yes, but time-consuming and difficult to understand. And: what do you wear ? clemens From owner-ageing@net.bio.net Mon Dec 09 22:00:00 1996 Path: biosci!agate!howland.erols.net!newsfeed.internetmci.com!btnet!btnet-feed1!zetnet.co.uk!not-for-mail From: Michael Quarrinton Newsgroups: bionet.molbio.ageing Subject: Superhormones Date: Tue, 10 Dec 1996 11:53:06 GMT Lines: 9 Message-ID: <1996121011530675438@zetnet.co.uk> NNTP-Posting-Host: deansgate.zetnet.co.uk X-Mailer: ZIMACS Version 1.09z 10003767 Does anybody know much about Dr William Regelson, a professor of medicine at the Medical College of Virginia, and his work regarding superhormones and their effect on ageing? I'd like to take these hormones but I don't know which ones or where to buy them. I've heard mention of droepiandrosterone (DHEA), but where do you get it and how much do you take? Mike Q'. From owner-ageing@net.bio.net Mon Dec 09 22:00:00 1996 Path: biosci!WWW.DCC.ANAHUAC.MX!med45902 From: med45902@WWW.DCC.ANAHUAC.MX Newsgroups: bionet.molbio.ageing Subject: (none) Date: 10 Dec 1996 06:44:42 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 4 Sender: daemon@net.bio.net Distribution: world Message-ID: <199612101444.GAA20574@net.bio.net> NNTP-Posting-Host: net.bio.net I'd like to know more about Werner Syndrome, I'll thank everyone who can help me... I'm a Medicine student From owner-ageing@net.bio.net Mon Dec 09 22:00:00 1996 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!info.uah.edu!news.lsu.edu!news.LaTech.edu!news.ttu.edu!news.tamu.edu!news From: Dawn Newsgroups: bionet.molbio.ageing Subject: Werner's Syndrome Date: Tue, 10 Dec 1996 09:18:39 -0600 Organization: Texas A&M Univ., College of Medicine, Dept of Med. Bioch. and Genetics Lines: 9 Message-ID: <32AD7F4F.6C1A@bigfoot.com> References: <199612101444.GAA20574@net.bio.net> Reply-To: dawnc@bigfoot.com NNTP-Posting-Host: ppp1b-05.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) CC: med45902@WWW.DCC.ANAHUAC.MX Werner's Syndrom is the pre-aging disease (you know that). I'm a researcher in aging (grad student). Scientific American (or was it Science) did an excellent article on those disease (Progeria, etc...) a few months back.. I'll see if I can find the article... but who knows.. try to find their web site (scientific American - and request the back issue. -- Visit: http://members.aol.com/CappSci ...Because the Alternative is Illogical ;-) From owner-ageing@net.bio.net Mon Dec 09 22:00:00 1996 Path: biosci!rutgers!uwm.edu!cs.utexas.edu!howland.erols.net!news.sprintlink.net!news-peer.sprintlink.net!worldnet.att.net!uunet!in1.uu.net!128.255.40.11!news.uiowa.edu!hardin9.lib.uiowa.edu!user From: eric-rumsey@uiowa.edu (Eric Rumsey) Newsgroups: bionet.molbio.ageing Subject: WWW: Hardin Meta Directory update - Geriatrics Date: 10 Dec 1996 17:11:41 GMT Organization: University of Iowa, Hardin Library for the Health Sciences Lines: 29 Message-ID: NNTP-Posting-Host: hardin9.lib.uiowa.edu The Geriatrics page of the Geriatrics has recently been updated. In the year since the Meta Directory was launched, the quantity and quality of Internet resources has grown greatly in most disciplines. But Geriatrics stands out as a discipline that has gone from a relative sparsity of good resources to a great wealth. This is reflected in the new lists (and greatly improved ones that were already in the Meta Directory) that have been added, including the following new ones - -Index to Eldercare on the WWW, Eldercare Web, Karen S Brown -Golden Age Net, Donna McCafferty, SW Texas State Univ -Interactive Aging Network -Gerontology Resource List, Aaron Abbott, Miami (OH) Univ In addition to adding new lists in the Meta Directory, all links have been checked to confirm connection. The URL for the Hardin Meta Directory Geriatrics page is - http://www.arcade.uiowa.edu/hardin-www/md-ger.html Please check it out ! * * * * * * * * * Eric Rumsey, Hardin Library for the Health Sciences University of Iowa, Iowa City IA 52242 319-335-9875 (voice), 319-335-9897 (fax) Hardin Meta Directory of Internet Health Sources http://www.arcade.uiowa.edu/hardin-www/md.html From owner-ageing@net.bio.net Wed Dec 11 22:00:00 1996 Path: biosci!IMMORTALITY.ORG!duane From: duane@IMMORTALITY.ORG (Duane Hewitt) Newsgroups: bionet.molbio.ageing Subject: Werner's Syndrome Date: 11 Dec 1996 18:36:10 -0800 Organization: Immortality, Inc. Lines: 10 Sender: daemon@net.bio.net Distribution: world Message-ID: <32AF6F59.32C5@immortality.org> NNTP-Posting-Host: net.bio.net The article that you mention was in the April 12th issue of Science. The abstract of the paper is available at http://www.sciencemag.org/science/scripts/display/short/272/5259/258.html A summary is also available at my web site. Duane Hewitt http://immortality.org From owner-ageing@net.bio.net Wed Dec 11 22:00:00 1996 Path: biosci!pbi.nrc.ca!klai From: klai@pbi.nrc.ca ("Lai, Ken") Newsgroups: bionet.molbio.ageing Subject: RE: Your GOD Loves You - YES YOU! Date: 12 Dec 1996 10:41:53 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 36 Sender: daemon@net.bio.net Distribution: world Message-ID: <32B06E13@gate1.pbi.nrc.ca> NNTP-Posting-Host: net.bio.net From: BIOSCI-REQUEST To: aging Subject: Your GOD Loves You - YES YOU! Date: Thursday, December 12, 1996 12:10AM >I hope that you know your GOD loves you, no matter what GOD you believe in. >Thank your GOD for life and ask your GOD to let you live as your GOD would >want >you to. When we look closely at GOD we begin to realize that we all believe >in the >same GOD, we may see GOD in different ways, but GOD will always be GOD. There >can only be one GOD, and that one GOD loves us all, and wants nothing but the >best for us. If your in doubt, just remember GOD works in mysterious ways, >there is >a reason for everything... God thank you. Someone I wish that this group was moderated against spam mail!!! Furthermore to the person who wrote this-->here is some food for thought: Jesus Christ said that he was the one and only way to redemption, salvation and life after death, therefore how can you state. "I hope that you know your GOD loves you, no matter what GOD you believe in....[and].... When we look closely at GOD we begin to realize that we all believe in the same GOD, we may see GOD in different ways, but GOD will always be GOD." If you want to talk more about this contact me more at klai@pbi.nrc.ca From owner-ageing@net.bio.net Sat Dec 14 22:00:00 1996 Path: biosci!IMMORTALITY.ORG!duane From: duane@IMMORTALITY.ORG (Duane Hewitt) Newsgroups: bionet.molbio.ageing Subject: Hayflick limit. Date: 15 Dec 1996 07:50:37 -0800 Organization: Immortality, Inc. Lines: 18 Sender: daemon@net.bio.net Distribution: world Message-ID: <32B41E48.6A0B@immortality.org> NNTP-Posting-Host: net.bio.net The Hayflick limit refers to a phenomenon that occurs when human cells are grown in tissue culture. Under these conditions it is observed that the population can only double a limited number of times (around 50) before the cells senesce and are unable to grow any more. It is named after noted biogerontologist Leonard Hayflick. The Hayflick limit varies amongst different cells and depends mainly on their physiological age. Fetal cells can divide 50 +/-10 times. However cells from patients afflicted with "accelerated aging" syndromes such as Werners syndrome or Progeria are not capable of dividing as many times as cells from normal individuals who are the same chronological age. The number of times cells can divide decreases with age. Duane Hewitt http://immortality.org From owner-ageing@net.bio.net Sat Dec 14 22:00:00 1996 Path: biosci!rutgers!uwm.edu!www.nntp.primenet.com!nntp.primenet.com!news.sprintlink.net!news-peer.sprintlink.net!worldnet.att.net!uunet!in3.uu.net!192.220.251.22!netnews.nwnet.net!news-hub.interserv.net!news.interserv.com!news From: phis@sprynet.com (James Howard) Newsgroups: bionet.molbio.ageing Subject: Bupropion, Smoking, Melatonin and DHEA Date: Sun, 15 Dec 1996 20:03:45 GMT Organization: InterServ News Service Lines: 117 Message-ID: <591l5b$bn8@lal.interserv.com> NNTP-Posting-Host: dd35-214.compuserve.com X-Newsreader: Forte Free Agent 1.0.82 Bupropion, Smoking, Melatonin and DHEA James Howard It has just been announced that the antidepressant, bupropion, will be marketed as "the first smoking-cessation therapy that doesn’t contain nicotine." (Buproprion is also known as "wellbutrin.") The maker of bupropion, Glaxo Wellcome, says its studies show bupropion is more effective than the nicotine patch. "In one study of 843 patients, 49 percent who took bupropion quit smoking after four weeks, compared with 36 percent of the patients who used [nicotine] patches." Well, I developed an explanation for why people smoke that also explained why kids are increasingly beginning to smoke. This idea is based on my theory of DHEA and melatonin. When I read about bupropion, I immediately decided to see if the drug had any effects on DHEA or melatonin. I found a direct connection of bupropion and melatonin that directly fits my explanation of smoking. The article containing the quotations included in this paragraph also said: "Glaxo, which is the U.S. unit of British pharmaceutical giant Glaxo Wellcome Plc, reported sales of $50.5 million for its Wellbutrin antidepressant in the first six months of this year." Perhaps, there is a cheap alternative to bupropion that is also a natural product of your body, rather than a product of chemical manufacturing. I intend to show you that the effect of bupropion in inhibiting smoking is simply that it stimulates our natural hormone, melatonin. Melatonin is freely available and cheap. To explain this to you, I am including the following "letter to the editor," that I had published in "The Morning News of Northwest Arkansas," October 8, 1995. This is a good summary of my explanation of smoking. "In 1985, I copyrighted a mechanism of sleep in which the hormone melatonin and the hormone DHEA cycle to produce sleep and consciousness. [You can read this in detail at http://www.naples.net/~nfn03605 on the internet.] My work directly links them; one affects production of the other. DHEA is used during the day to maintain consciousness and is literally ‘used up.’ We get tired at the end of the day. This loss of DHEA stimulation allows the pineal gland (where melatonin is made) to release melatonin. This large release of melatonin starts the first, very important slow wave sleep by slowing release (not production) of prolactin, which is known to specifically stimulate DHEA. During the night, melatonin is also used up; then, a large release of prolactin triggers the large morning release of DHEA that triggers awakening. this completes the cycle. I think it is necessary for growth and development. To understand how nicotine works, remember that melatonin first inhibits DHEA, then participates in DHEA release when melatonin declines. Nicotine mimics melatonin. The structure of nicotine is very similar to melatonin; so are caffeine, cocaine, methamphetamine and, seemingly contradictory, so are narcotics. I think all of these attach to melatonin’s ‘doorways’ (receptors) in the brain, and I think they all, ultimately, stimulate DHEA. They are better at this than melatonin. Nicotine is proven to stimulate DHEA ("The New England Journal of Medicine" 318: 1705). In the case of nicotine, I suggest people first use it like melatonin, to block the stimulatory effects of DHEA. They use it to relax. I suggest the pleasure centers deliver pleasure when the are temporarily relaxed or inhibited, e.g. at the end of sex. Therefore, nicotine relaxes the pleasure center, which then leads to further DHEA stimulation, which then resets the pleasure center by stimulating it. The smoker then seeks relaxation again. This relaxation and stimulation become so connected in time, by frequent smoking, that relaxation, i.e., pleasure and stimulation become simultaneous. As this mechanism is continued DHEA production increases; this requires increased nicotine to relax the pleasure center. This is addiction. other drugs have differing times of attachment to, and activity at, the melatonin receptor and, therefore, differing effects on the amount of DHEA production. Addiction looks different, but the mechanism is the same. Near puberty, melatonin production declines, and DHEA production rises, both dramatically. Because of this, DHEA is then used by the brain for stimulation, not growth and development. This begins puberty and is the reason teen-agers are so full of energy. This is the time most people start smoking and become addicted. I suggest it is due to the decline in melatonin and increase in DHEA. Kids are reaching puberty earlier now than in the past, and smoking among our youth is also increasing in the face of a very expensive and well-directed anti-smoking campaign." Again, I suggested it is the loss of melatonin that triggers the appetite for nicotine. It is proven that bupropion increases melatonin production. That is, not only bupropion, but other antidepressants, increase melatonin production. "Twenty-four-hour urinary excretion of 6-hydroxymelatonin and ‘whole body norepinephrine (NE) turnover,’ ie, 24-hour urinary ouput of NE and its major metabolites 3-methoxy-4-hydroxphenylglycol, vanillylmandelic acid, and normetanephrine, were measured before and after treatment with the tricyclic desipramine hydrochloride, the aminoketone bupropion hydrochloride, the nonselective monoamine oxidase (MAO) inhibitor tranylcypromine sulfate, and the specific MAO type A inhibitor clorgiline. 6-Hydroymelatonin excretion increased following antidepressant treatment, while at the same time whole-body NE turnover was reduced." (Archives of General Psychiatry 1988; 45: 150). Urinary excretion of 6-hydroxymelatonin is considered a convincing measurement of melatonin production. "This study validates the comparison of plasma levels of the hormone [melatonin] or urinary levels of its metabolite [6- hydroxymelatonin] to assess pineal gland production of melatonin in humans." ("Clin. Chim. Acta 1985; 150: 221). The connection of bupropion and melatonin has been reported as late as 1995: Ascher, JA, et al., "Burpropion: A Review of its Mechanism of Antidepressant Activity," Journal of Clinical Psychiatry 1995 (Sept.); 56: 395. The review reports that "The mechanism of action of the novel antidepressant bupropion remains unclear after many years of study." One of the five listings of known findings about bupropion in "Results" is: "5) Clinical studies indicate that bupropion enhances noradrenergic functional activity as reflected by an increased excretion of the hydroxy metabolite of melatonin..." I think bupropion helped some smokers quit by increasing melatonin. Because of the mechanism I advance to explain smoking, I see two kinds of potential smokers. I think some smoke because of too much DHEA, in other words, to relax. This kind of smoker seeks to decrease DHEA. I think some smoke to increase DHEA, that is, to stimulate themselves. The same mechanism will satisfy both of these needs. It just happens that both kinds of smokers become addicted. If I am correct that bupropion helps smokers quite by stimulating melatonin, then it should only help about half. Look back at the percentage helped by bupropion, mentioned in the first paragraph; bupropion helped 49 percent. I think it would be far more appropriate to take a small amount of melatonin than either nicotine or bupropion, and the cost of melatonin is far below that of either nicotine or bupropion. I did the experiment. I took a small amount of melatonin, along with my regular DHEA, during the day. Of course, it may be my expectation, but I perceived an increase in awareness and activity. James Howard From owner-ageing@net.bio.net Sun Dec 15 22:00:00 1996 Path: biosci!agate!howland.erols.net!worldnet.att.net!arclight.uoregon.edu!super.zippo.com!zdc!szdc!news From: "Daniel G. Sanchez" Newsgroups: bionet.molbio.ageing Subject: Re: Bupropion, Smoking, Melatonin and DHEA Date: Sun, 15 Dec 1996 20:02:59 -0800 Organization: Bio-Nutrients Unlimited Lines: 29 Message-ID: <32B4C9F3.3DF4@greenheart.com> References: <591l5b$bn8@lal.interserv.com> Reply-To: supernet@greenheart.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0Gold (Win95; I) Dear James, I liked your post very much. You showed some very interesting parallels. It is my understanding that you should take the Melatonin just before bedtime when it is dark and not during the day. What would be the consequences of taking Melatonin during the day? Melatonin is a hormone but Nicotine is not. Melatonin may have a similar effect as nicotine but to use it during the day could throw the interplay of the body's hormones off balance. What doctor would recommend to a smoker to take Melatonin during the day to break the habit? I can see taking DHEA during the morning and day because that's when the body produces it. Although compelling, would you seriously recommend to a broad base of people to take Melatonin during the day? I see that you have already started to take it during the day along with your DHEA. What dosage are you taking? Your increase in awareness and activity may only be due to the DHEA. Keep us posted on your results, although I am in no way encouraging you to continue to do this. James Howard wrote: > > Bupropion, Smoking, Melatonin and DHEA > >I did the experiment. I took a small amount of melatonin, along > with my regular DHEA, during the day. Of course, it may be my expectation, > but I perceived an increase in awareness and activity. > James Howard From owner-ageing@net.bio.net Sun Dec 15 22:00:00 1996 Path: biosci!rutgers!uwm.edu!news-peer.gsl.net!news.gsl.net!howland.erols.net!news.bbnplanet.com!cam-news-hub1.bbnplanet.com!uunet!in2.uu.net!192.220.251.22!netnews.nwnet.net!news-hub.interserv.net!news.interserv.com!news From: phis@sprynet.com (James Howard) Newsgroups: bionet.molbio.ageing Subject: Re: Bupropion, Smoking, Melatonin and DHEA Date: Mon, 16 Dec 1996 15:45:59 GMT Organization: InterServ News Service Lines: 44 Message-ID: <593qdm$33c@lal.interserv.com> References: <591l5b$bn8@lal.interserv.com> <32B4C9F3.3DF4@greenheart.com> NNTP-Posting-Host: hd49-111.compuserve.com X-Newsreader: Forte Free Agent 1.0.82 "Daniel G. Sanchez" wrote: >It is my understanding that you should take the Melatonin just before >bedtime when it is dark and not during the day. What would be the >consequences of taking Melatonin during the day? Melatonin is a hormone >but Nicotine is not. Melatonin may have a similar effect as nicotine >but to use it during the day could throw the interplay of the body's >hormones off balance. What doctor would recommend to a smoker to take >Melatonin during the day to break the habit? I can see taking DHEA >during the morning and day because that's when the body produces it. >Although compelling, would you seriously recommend to a broad base of >people to take Melatonin during the day? I see that you have already >started to take it during the day along with your DHEA. What dosage are >you taking? Your increase in awareness and activity may only be due to >the DHEA. Keep us posted on your results, although I am in no way >encouraging you to continue to do this. James Howard responds: Daniel, thank you for your response. You should know that the melatonin - DHEA cycle continues throughout the day and night. It so happens that evolution saw to it that one dominates during the day, the other at night. When one exercises, both are stimulated. I suggest the 24 hour cycle and the co-secretion during exercise, etc. result from the need for the cycle to occur. I have long thought this, but have not addressed it per se. It is difficult enough presenting my theory without including all aspects. When I wrote the post, to which you responded, it became clear to me that nicotine and bupropion must be exerting their effects by stimulating melatonin, which, ultimately, stimulates DHEA. That is why I decided to try them together. I anticipated two possible results, that is, I expected to become drowsy or I expected effects similar to smoking. The result I got was similar to what smoking my pipe used to do for me; heightened awareness and energy. I took the same amount of DHEA I normally consumed around the same time of day. The combination of DHEA and melatonin was better than DHEA alone. You should have deduced from my post that I think people take nicotine, caffeine, etc. to boost the melatonin (MLT) - DHEA cycle. If any natural or synthetic products stimulate the body/brain, I suspect they are activating the MLT-DHEA cycle in some way. I think it is demonstrable that bupropion is doing that. I am certain I would rather take a small amount of MLT and DHEA, rather than nicotine or bupropion. From owner-ageing@net.bio.net Mon Dec 16 22:00:00 1996 Path: biosci!rutgers!gatech!www.nntp.primenet.com!nntp.primenet.com!howland.erols.net!worldnet.att.net!uunet!in3.uu.net!192.220.251.22!netnews.nwnet.net!news-hub.interserv.net!news.interserv.com!news From: phis@sprynet.com (James Howard) Newsgroups: bionet.molbio.ageing Subject: daytime fatigue (sleepiness) relief Date: Tue, 17 Dec 1996 17:22:13 GMT Organization: InterServ News Service Lines: 18 Message-ID: <596kea$43c@lal.interserv.com> NNTP-Posting-Host: ad10-005.compuserve.com X-Newsreader: Forte Free Agent 1.0.82 I recently had the occasion to explain how wellbutrin (bupropion) may help people stop smoking; you can read it as "Bupropion, Smoking, Melatonin, and DHEA" at sci.life-extension and some other groups. During my work on this, I came to the conclusion that a small amount of melatonin should releive daytime fatigue and sleepiness. This seems contradictory to most ideas about melatonin; I considered it contrary to my theory of sleep at http://www.naples.net/~nfn03605, but, again, my work on my bupropion idea suggested that it might work. Well, I have taken about 1 mg of melatonin a number of occasions during a time when I felt I would have to give up, due to fatigue or sleepiness, and go ahead and nap. Well, this small amount of melatonin actually revives me; it takes about 20 mins for me to feel the effects. This is so dramatic that I thought this newsgroup should know about this. Please bear in mind that I also take DHEA, which I think is necessary for the effect. I know how frustrating daytime fatigue and sleepiness can be. I hope this works for others. James Howard From owner-ageing@net.bio.net Fri Dec 20 22:00:00 1996 Path: biosci!CS.Arizona.EDU!news.Arizona.EDU!hamblin.math.byu.edu!sol.ctr.columbia.edu!news.msfc.nasa.gov!www.nntp.primenet.com!nntp.primenet.com!ix.netcom.com!netcom.net.uk!btnet!btnet-feed1!zetnet.co.uk!not-for-mail From: Michael Quarrinton Newsgroups: bionet.molbio.ageing Subject: Re: DHEA Date: Fri, 20 Dec 1996 13:46:54 GMT Lines: 7 Message-ID: <1996122013465475438@zetnet.co.uk> References: <591l5b$bn8@lal.interserv.com> <32B4C9F3.3DF4@greenheart.com> NNTP-Posting-Host: deansgate.zetnet.co.uk X-Mailer: ZIMACS Version 1.09z 10003767 Excuse my ignorance but where can I buy DHEA in the UK, what does it do and how much do I need to take? Mike From owner-ageing@net.bio.net Sun Dec 22 22:00:00 1996 Path: biosci!CALUM.CSCLUB.UWATERLOO.CA!s-garan From: s-garan@CALUM.CSCLUB.UWATERLOO.CA ("Steven A. Garan") Newsgroups: bionet.molbio.ageing Subject: Re: Theories on Ageing Date: 23 Dec 1996 10:10:55 -0800 Organization: ARC Lines: 2 Sender: daemon@net.bio.net Distribution: world Message-ID: <32BECBB8.605D37E8@csclub.uwaterloo.ca> NNTP-Posting-Host: net.bio.net You might wish to look at the WWW site at www.hookup.net/mall/aging From owner-ageing@net.bio.net Wed Dec 25 22:00:00 1996 Path: biosci!rutgers!cnn.Princeton.EDU!cbgw1.lucent.com!fnnews.fnal.gov!gannett.math.niu.edu!corn.cso.niu.edu!vixen.cso.uiuc.edu!howland.erols.net!worldnet.att.net!uunet!in3.uu.net!192.220.251.22!netnews.nwnet.net!news-hub.interserv.net!news.interserv.com!news From: phis@sprynet.com (James Howard) Newsgroups: bionet.molbio.ageing Subject: daytime fatigue (sleepiness) relief Date: Tue, 17 Dec 1996 17:22:13 GMT Organization: InterServ News Service Lines: 18 Message-ID: <596kea$43c@lal.interserv.com> NNTP-Posting-Host: ad10-005.compuserve.com X-Newsreader: Forte Free Agent 1.0.82 I recently had the occasion to explain how wellbutrin (bupropion) may help people stop smoking; you can read it as "Bupropion, Smoking, Melatonin, and DHEA" at sci.life-extension and some other groups. During my work on this, I came to the conclusion that a small amount of melatonin should releive daytime fatigue and sleepiness. This seems contradictory to most ideas about melatonin; I considered it contrary to my theory of sleep at http://www.naples.net/~nfn03605, but, again, my work on my bupropion idea suggested that it might work. Well, I have taken about 1 mg of melatonin a number of occasions during a time when I felt I would have to give up, due to fatigue or sleepiness, and go ahead and nap. Well, this small amount of melatonin actually revives me; it takes about 20 mins for me to feel the effects. This is so dramatic that I thought this newsgroup should know about this. Please bear in mind that I also take DHEA, which I think is necessary for the effect. I know how frustrating daytime fatigue and sleepiness can be. I hope this works for others. James Howard From owner-ageing@net.bio.net Thu Dec 26 22:00:00 1996 Path: biosci!rutgers!netnews.upenn.edu!msunews!news.mtu.edu!sol.ctr.columbia.edu!spool.mu.edu!newspump.sol.net!howland.erols.net!newsfeed.internetmci.com!vic.com!news From: (steffin@heart.com) Newsgroups: bionet.molbio.ageing Subject: Please Help!!! Date: Wed, 18 Dec 1996 22:24:13 GMT Organization: Virtual Interactive Center Lines: 120 Message-ID: <32b86f01.113747133@news.inet-direct.com> NNTP-Posting-Host: 208.128.111.238 X-Newsreader: Forte Free Agent 1.1/16.230 Recently I wrote a letter from my heart regarding my foster mother Wendy Mcghee. She had no knowledge of this letter unitl she started receiving lovely cards. But then came some nasty letters. She is asking me to repost her letter here. ----------------------------------------------------------------------------------------------- "Thank you for the wonderful cards! I have returned the gifts that I could to the senders. Other gifts without return addresses were given to the Salvation Army. I am sure however that there is a child in your area who may go without a Christmas. I am asking therefore thank you take your gift and good will and make that local child a little happier at Christmas Sincerely, Wendy McGhee " ----------------------------------------------------------------------------------------------- I would also like to add something. This was not a scam! And for those of you who wrote those nasty letters, "Shame on you!!!" This was simply something I wanted to do to make the lady that cared for me and others so much to know that she is loved for what she has done. No one had to send money or gifts or even a card. This was a request that IF you felt like doing so show some kindness. Kind words would have been ENOUGH. She didn't do anything to deserve some of the letters that were sent. As she wrote to me she is returning the gifts and donating the one that are unreturnable. And for those of you reading this for the first time, it would be great if you could simply sent a postcard or letter to her for her birthday the 27th of December. Tell thanks for the kindness she's shown others and tell her I said I love her. ----------------------------------------------------------------------------------------------- The letter I previously posted: "Thanks for taking the time to read this message! This is about a lady that gave all she could to everyone, including me. Her name is Wendy. When I was young she became my foster mother after my real mother had abandon me. Never having any kids of her own she became a foster parent. That I got to be in her care was probably the best thing that had ever happened to me. She had other foster children and even ended up taking care of many of the neighborhood kids. Wendy is a lady that just never gave up and always gave more than anyone could imagine. I no longer think of my real mother as mother but rather Wendy as my only true mother. I know that I'm not the only one that thinks that way either. It wasn't just kids that she helped it included the elderly, the disabled and the just down and out. What it takes to qualify for a saint is something I never found out, but I know it can't be more than the things I saw this lady do for anybody. Even people that had wronged her could find themselves looking up at her while she helped them when they were down. I'm 26 now and many of the things I'm telling you I never really realized until now. Since I was a kid she has helped me with everything from recovering from my mistakes to just being there to say "You can do it... It'll be okay." I've never been able to make a good attempt at trying to repay her for all she's done for me and I'm not alone. Many people just have taken for granted the things she's done for them. I know by now you're asking yourself why I've posted this letter. Well, to be honest and straight with you it's because I would like your help. If there's one thing that I've learned from Wendy it's that, "We are our neighbors keepers." You know the golden rule, "Do onto others as you would have them do onto you." Anyway now Wendy is an older lady that is disabled and can't do as much as she used to. With the disability sometimes expenses can be too much. I now live in Arkansas and can't be of much help. With no real family I'd like to do something to try to repay all she done for me and many others. That's were you come in. See if you can think back to someone that helped you no matter how big or small. Maybe it's someone you can't even remember or have lost touch with. For that moment picture Wendy and say, "I'd like to repay that kindness." I wish you would sit down and write a small note saying "Thanks for being the generous person that you have been!" If you could include something to help out. Maybe it's a five dollar bill, a book of stamps, even a dollar. Oh and would you also tell her the Steffin sends his love. Her birthday is this month on the 27th and I'm hoping I can make this own a very memorable one. Thanks for reading and if you choose to help God pless you. Her address is Wendy Mcghee 9636 Elm Taylor, Mi 48180" From owner-ageing@net.bio.net Thu Dec 26 22:00:00 1996 Path: biosci!lhc.nlm.nih.gov!biosci!rutgers!netnews.upenn.edu!msunews!news.mtu.edu!sol.ctr.columbia.edu!spool.mu.edu!newspump.sol.net!howland.erols.net!newsfeed.internetmci.com!vic.com!news From: (steffin@heart.com) Newsgroups: bionet.molbio.ageing Subject: Please Help!!! Date: Wed, 18 Dec 1996 22:24:13 GMT Organization: Virtual Interactive Center Lines: 120 Message-ID: <32b86f01.113747133@news.inet-direct.com> NNTP-Posting-Host: 208.128.111.238 X-Newsreader: Forte Free Agent 1.1/16.230 Recently I wrote a letter from my heart regarding my foster mother Wendy Mcghee. She had no knowledge of this letter unitl she started receiving lovely cards. But then came some nasty letters. She is asking me to repost her letter here. ----------------------------------------------------------------------------------------------- "Thank you for the wonderful cards! I have returned the gifts that I could to the senders. Other gifts without return addresses were given to the Salvation Army. I am sure however that there is a child in your area who may go without a Christmas. I am asking therefore thank you take your gift and good will and make that local child a little happier at Christmas Sincerely, Wendy McGhee " ----------------------------------------------------------------------------------------------- I would also like to add something. This was not a scam! And for those of you who wrote those nasty letters, "Shame on you!!!" This was simply something I wanted to do to make the lady that cared for me and others so much to know that she is loved for what she has done. No one had to send money or gifts or even a card. This was a request that IF you felt like doing so show some kindness. Kind words would have been ENOUGH. She didn't do anything to deserve some of the letters that were sent. As she wrote to me she is returning the gifts and donating the one that are unreturnable. And for those of you reading this for the first time, it would be great if you could simply sent a postcard or letter to her for her birthday the 27th of December. Tell thanks for the kindness she's shown others and tell her I said I love her. ----------------------------------------------------------------------------------------------- The letter I previously posted: "Thanks for taking the time to read this message! This is about a lady that gave all she could to everyone, including me. Her name is Wendy. When I was young she became my foster mother after my real mother had abandon me. Never having any kids of her own she became a foster parent. That I got to be in her care was probably the best thing that had ever happened to me. She had other foster children and even ended up taking care of many of the neighborhood kids. Wendy is a lady that just never gave up and always gave more than anyone could imagine. I no longer think of my real mother as mother but rather Wendy as my only true mother. I know that I'm not the only one that thinks that way either. It wasn't just kids that she helped it included the elderly, the disabled and the just down and out. What it takes to qualify for a saint is something I never found out, but I know it can't be more than the things I saw this lady do for anybody. Even people that had wronged her could find themselves looking up at her while she helped them when they were down. I'm 26 now and many of the things I'm telling you I never really realized until now. Since I was a kid she has helped me with everything from recovering from my mistakes to just being there to say "You can do it... It'll be okay." I've never been able to make a good attempt at trying to repay her for all she's done for me and I'm not alone. Many people just have taken for granted the things she's done for them. I know by now you're asking yourself why I've posted this letter. Well, to be honest and straight with you it's because I would like your help. If there's one thing that I've learned from Wendy it's that, "We are our neighbors keepers." You know the golden rule, "Do onto others as you would have them do onto you." Anyway now Wendy is an older lady that is disabled and can't do as much as she used to. With the disability sometimes expenses can be too much. I now live in Arkansas and can't be of much help. With no real family I'd like to do something to try to repay all she done for me and many others. That's were you come in. See if you can think back to someone that helped you no matter how big or small. Maybe it's someone you can't even remember or have lost touch with. For that moment picture Wendy and say, "I'd like to repay that kindness." I wish you would sit down and write a small note saying "Thanks for being the generous person that you have been!" If you could include something to help out. Maybe it's a five dollar bill, a book of stamps, even a dollar. Oh and would you also tell her the Steffin sends his love. Her birthday is this month on the 27th and I'm hoping I can make this own a very memorable one. Thanks for reading and if you choose to help God pless you. Her address is Wendy Mcghee 9636 Elm Taylor, Mi 48180" From owner-ageing@net.bio.net Fri Dec 27 22:00:00 1996 Path: biosci!news.artemis.com!uunet!in2.uu.net!205.252.116.190!feed1.news.erols.com!howland.erols.net!usc!usc!not-for-mail From: william@neuro.usc.edu (William Sun) Newsgroups: bionet.molbio.ageing Subject: companies doing aging research Date: 27 Dec 1996 16:04:29 -0800 Organization: University of Southern California, Los Angeles, CA Lines: 13 Sender: william@neuro.usc.edu Message-ID: <5a1o6d$7hc@neuro.usc.edu> NNTP-Posting-Host: neuro.usc.edu Hello all, I am interested in finding out the name of biotech or pharmaceutical companies that are actively doing research in aging. If you have any information, please reply! Thanks. -William -- William Sun, Ph.D Phone: (213)740-3406 Neuroscience Program FAX: (213)740-5687 University of Southern California Pager: (310)243-9878 Los Angeles, CA 90089-2520 http://www-bcf.usc.edu/~wisun/ From owner-ageing@net.bio.net Fri Dec 27 22:00:00 1996 Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!news.ecn.uoknor.edu!feed1.news.erols.com!arclight.uoregon.edu!newsfeed.direct.ca!nntp.portal.ca!van-bc!unixg.ubc.ca!news From: BRowley@alumni.ubc.ca (Brian C. Rowley) Newsgroups: bionet.molbio.ageing Subject: new longevity group Date: Sat, 28 Dec 1996 09:42:06 GMT Organization: Longevity-Digest Lines: 145 Message-ID: <5a2m96$f9b@nntp.ucs.ubc.ca> Reply-To: BRowley@alumni.ubc.ca NNTP-Posting-Host: port06.annex2.net.ubc.ca X-Newsreader: Forte Free Agent 1.0.82 From: "Brian C. Rowley" Subject: New Longevity List LONGEVITY-DIGEST I would like to announce the creation of Longevity-Digest, an E-mail group devoted to the science of aging. I am Brian Rowley (BS, MS), owner and moderator. SUBSCRIBING AND UNSUBSCRIBING To subscribe, send E-mail to LISTSERV@VM.EGE.EDU.TR that reads: subscribe longevity-digest firstname lastname Write your full name where it says "firstname lastname". To unsubscribe, send E-mail to LISTSERV@VM.EGE.EDU.TR that reads: signoff longevity-digest If subscription with LISTSERV is unsuccessful, write to me at browley@alumni.ubc.ca, giving your full name or an alias. MISSION Longevity-Digest is designed to bring together scientists and laypersons interested in diverse aspects of longevity science. Some will be molecular biologists, some endocrinologists, some life extensionists, some pharmacologists, some demographers... The subject matter of this list is of great importance. Aging is the most important risk factor for almost all causes of death. Right now, medical science is trying to prolong healthy life chiefly by attacking disease directly. But at some point in life this approach serves only to prolong morbidity. We are unlikely to get beyond a life expectancy of 85 or so unless we treat the aging process itself (Olshansky, Carnes & Cassel 1990). Furthermore, even without any life expectation gain, the benefits of preserving a youthful physiology are incalculable. There is some reason for hope that effective treatments for aging will be found in our lifetime. For example, there are studies of shorter-lived species that document successful interventions in the aging process: (1) caloric restriction with ample micronutrients prolongs the life span of long-lived rodents (those already resistant to the diseases of aging) and a phylogenetically diverse array of other species (e.g., rotifers, daphnia, spiders, fish....), by up to 50% (Weindruch & Walford 1988). (2) the clonal life span of paramecia can be increased 33% by consecutive treatments of damaging (nucleotide fusing) UV and undamaging (nucleotide splitting) UV. Damaging and undamaging the DNA is hypothesized to trick cells into mobilizing a reserve DNA repair capacity that can reverse age-accumulated damage (Smith-Sonneborn 1979). Such a reserve is probably enormous--how else to explain the complete reversal of senescence routinely seen in paramecia after fission and reconjugation; the same rejuvenation occurs each time a sperm combines with an egg, otherwise each new generation would be "older" than the last. (3) Liu & Walford (1975) have found that lowering the body temperature of C. bellottii fish from 20 to 15 degrees Celsius adds over 80% to the life span. Complex metabolic changes, not simply a “lowered metabolism”, seem implicated. (4) Odens (1973) has found that weekly injections of RNA and DNA, starting at 750 days of life in rats that live 800-900 days, more than doubles survival to about 1800 days. (5) Combinations of daf-2 and daf-12 mutant alleles nearly quadruple the adult life span of C. elegans nematodes (Larsen, Albert & Riddle 1995). As a result of these successes, it would be premature to conclude that nothing will ever be done about aging, and it is certainly true that underlying mechanisms of aging can be studied in a laboratory setting. Less mainstream researchers (e.g., life extensionists and cryonicists) are welcome along with more traditional scientists--in my view, good research is defined not only by tidy puzzle-solving and the amount of accumulated evidence, but also by potential application and importance to people's lives. As a result, scientists from both traditional and non-traditional areas are welcome. POSTING To post a message to Longevity-Digest, send E-mail to Longevity-Digest@vm.ege.edu.tr. It is recommended that you subscribe first. ACTIVITIES Each week, Longevity-Digest invites one or more "guest speakers" from various fields related to longevity to post a few paragraphs describing their work, or giving information, opinions or ideas. In fact, anyone can be a "guest speaker" simply by sending a post and initiating a thread. Replies to "guest speaker" posts, if numerous, are collected and amalgamated into an E-mail digest (all authorships acknowledged), which is then distributed to subscribers via E-mail. The "guest speaker" is given a copy of the digest, and can reply to the replies. Exchanges on Longevity-Digest are less rapid-fire than on newsgroups, as posting can take from hours to days. However, junk is eliminated (see rules of moderation). The Longevity-Digest is also prepared to carry out subscribership polls on certain issues that wouldn't be possible with any other format, depending on subscriber interest. RULES OF MODERATION "Spams" (advertisements), "flames" (personal attacks), swear words, vapid musings, unaddressable complaints, conspiracy theories, excessive verbiage, redundancies, rants and gibberish will not be posted. These rules allow much flexibility, while giving posters freedom from junk mail and abuse. I also make 3 posting suggestions: (1) Strong claims should come with a description of the supporting evidence. (2) Opinions, speculation and theorizing should be presented as such; start sentences with "I think..." or "My hypothesis is...". (3) Anecdotes can be given, but should not be asserted as proof. Let me extend my warmest greetings to you. I am looking forward to making your acquaintance on Longevity-Digest, and I anticipate many exciting discussions :-> -Brian Rowley REFERENCES Olshansky, SJ, Carnes, BA and Cassel, C. In search of Methuselah: estimating the upper limits to human longevity. Science 250:634-640, 1990. Weindruch, R and Walford, RL. The Retardation of Aging and Disease by Dietary Restriction. Springfield, Illinois, Charles C. Thomas, publisher, 1988 pp. 31-72. Smith-Sonneborn, J. DNA repair and longevity assurance in Paramecium tetraurelia. Science 203:1115-1117, 1979. Liu, RK and Walford, RL. The effect of lowered body temperature on lifespan and immune and non-immune processes. Gerontologia 18:363-388, 1972. Odens, Max. Prolongation of the life span in rats. Journal of the American Geriatrics Society 21(10):450-451, 1973. Larsen, PL, Albert, PS and Riddle, DL. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139(4):1567-1583, 1995. From owner-ageing@net.bio.net Sat Dec 28 22:00:00 1996 Path: biosci!DIRECT.CA!jimwall From: jimwall@DIRECT.CA ("J. Wall") Newsgroups: bionet.molbio.ageing Subject: Neuropaedics Date: 29 Dec 1996 14:05:24 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 22 Sender: daemon@net.bio.net Distribution: world Message-ID: <32C6EB15.378E@direct.ca> NNTP-Posting-Host: net.bio.net Loss of stature during aging is associated with loss of thickness of intervertebral discs. Neuropaedic surgery is cervical disc replacement of narrowed spinal discs in the neck and restores length to vertebral arteries which supply blood flow to hindbrain and brain stem. This provides neuroprotection against strokes, headaches, blackouts, dizziness, intermittent blurred vision, tinnitus. Canadian Neuropaedic Foundation was incorporated June 1996 as a non-profit charitable foundation with tax registration number: Charity Registration No. 1093467-11. The Neuropaedic Project is planned for Vancouver BC Canada and Bellingham WA USA to develop screening protocols and clinics for disc replacement. CNF is seeking assistance with fund raising for this project which will ultimately benefit tens of millions of aging Americans, as cervical disc degeneration affects 97% of females and 100% of males at age 70. Please respond to: Canadian Neuropaedic Foundation #33-529 Johnstone Road, Parksville, BC, Canada, V9P 2K1 tel: (250) 752-0510 fax: (250) 752-0220 From owner-ageing@net.bio.net Sun Dec 29 22:00:00 1996 Newsgroups: bionet.molbio.ageing Path: biosci!agate!howland.erols.net!EU.net!news2.EUnet.fr!Belgium.EU.net!chaos.kulnet.kuleuven.ac.be!news.belnet.be!news.vub.ac.be!hnets.uia.ac.be!news From: Jos Vanhoudt Subject: MELATONIN=DANGEROUS? X-Nntp-Posting-Host: macbioch1.uia.ac.be Content-Type: text/plain; charset=us-ascii Message-ID: <32C7FA19.7AA6@uia.ua.ac.be> Sender: news@uia.ua.ac.be (News database) Content-Transfer-Encoding: 7bit Organization: UIA Mime-Version: 1.0 Date: Mon, 30 Dec 1996 17:21:29 GMT X-Mailer: Mozilla 2.0 (Macintosh; I; PPC) Lines: 9 I've been using melatonin for 18 months to solve my sleeping problem and never felt better since. A few months ago West-European governments have forbidden the selling of it! Why?? Is melatonin bad for your health?? Where can I still get it?? Please, mail me your answers. Joshua From owner-ageing@net.bio.net Sun Dec 29 22:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.erols.net!portc02.blue.aol.com!audrey01.news.aol.com!not-for-mail From: docclipper@aol.com (DocCLIPPER) Newsgroups: bionet.molbio.ageing Subject: Melatonin Date: 30 Dec 1996 22:49:06 GMT Organization: AOL http://www.aol.com Lines: 2 Message-ID: <19961230224700.RAA20864@ladder01.news.aol.com> References: <32C7FA19.7AA6@uia.ua.ac.be> NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com I have been using melatonin for 16 months without any problems. My sleep is greatly improved. From owner-ageing@net.bio.net Mon Dec 30 22:00:00 1996 Path: biosci!agate!howland.erols.net!newsfeed.internetmci.com!newsfeed.direct.ca!nntp.portal.ca!van-bc!unixg.ubc.ca!news.bc.net!rover.ucs.ualberta.ca!mongol.sasknet.sk.ca!news@mongol.sasknet.sk.ca From: Asha Newsgroups: bionet.molbio.ageing Subject: Cardiovascular Disease Date: Tue, 31 Dec 1996 15:44:05 -0600 Organization: SaskNet News Distribution Lines: 18 Message-ID: <32C98925.4E22@sk.sympatico.ca> NNTP-Posting-Host: amiot1.sk.sympatico.ca Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.02E-SYMPA (Win16; I) I have a link you might be interested in that would be included in the category of "cardiovascular disease." It's a site that specializes in Coenzyme Q10, and has an extensive medical references section on Coenzyme Q10 and disease, including specialized information on heart disease and vascular disease. Although our site has a commercial orientation, it contains alot of useful information regarding cardiovascular disease especially with regard to lipids, free radicals and antioxidants. http://www.nethomes.com/asha (homepage) URLs of interest: http://www.nethomes.com/asha/heart.htm http://www.nethomes.com/asha/heartref.htm http://www.nethomes.com/asha/order1.htm Asha Pharma Saskatoon, Canada From owner-ageing@net.bio.net Tue Dec 31 22:00:00 1996 From: "James Yegerlehner" Subject: Re: Neuropaedics References: <32C6EB15.378E@direct.ca> Organization: Agri-Logic Message-ID: <01bbf6bf$b2055160$435860ce@completebbs.com> X-Newsreader: Microsoft Internet News 4.70.1155 Date: 30 Dec 96 23:24:04 GMT Lines: 6 Newsgroups: bionet.molbio.ageing Path: biosci!daresbury!nntp-trd.UNINETT.no!nntp.uio.no!www.nntp.primenet.com!nntp.primenet.com!feed1.news.erols.com!howland.erols.net!newsfeed.internetmci.com!news.dsource.com!206.96.88.67 I suggest posting this to sci.life-extension. Are you soliticiting donations directly, or what? Jim Y.