From owner-ageing@net.bio.net Sat Feb 01 22:00:00 1997 Path: biosci!HUSC.HARVARD.EDU!kaljuvee From: kaljuvee@HUSC.HARVARD.EDU (Jurgen Kaljuvee) Newsgroups: bionet.molbio.ageing Subject: Where are the perfect repair systems? Date: 1 Feb 1997 18:35:04 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 59 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <32F3AC0C.31D8@njmug.org> Reply-To: Jurgen Kaljuvee NNTP-Posting-Host: net.bio.net On Sat, 1 Feb 1997, Nicholas Migliozzi wrote: > Hi. > What is the latest on anti-aging research? > Can it really be that aging is caused by genetics? > > If so, why does aging affect people in so many different ways? > No two old people suffer in the same way from old age. > Some live to 100. Others die at 60. Isn't this strange? > > I rather think that old age is "wear and tear". > A car gets old too, and certainly genetics is not to > blame here. > > Perhaps people get old in the same way that a car gets old. > What do scientists have against this theory? It is reasonable, > isn't it? Old cars. Old people. The same wear and tear. > > Thanks in advance, > Nicholas > Nicholas, People and cells are self-repairing systems, cars are not (any molecular biology textbook will describe several repair systems for both DNA and cytoplastic components). Another way of saying this is that cells and people use the energy of the environment (food) for not only movement (as cars do) but also to maintain, with the help of repair systems among other things, something called cellular homeostasis (equilibrium roughly speaking). If the repair systems were perfect, which they are not unfortunately, if all the damage and "wear and tear" were repaired perfectly, we could go on living much longer. A natural question arises: "If evolution has developed everything imaginable, why hasn't it developed perfect repair systems?" To answer the question, consider the following thought experiment. Suppose that several million years ago there was a species of, say, fish that developed a perfect repair systems and as a result couls achieve a lifespan that extended to several hundred or even thousands of years. If so, why don't we see the species today? Where did it disappear? The answer is that by attaining perfect repair system, the species lost the capacity for mutation and variation and consequently for evolution. It was soon outcompeted by a species which, though mortal on the individual level, carried superior mutations as a species. Evolution presumes variance, selection and mortality. So if human species developed perfect repair systems, not through evolution, but artificially in a lab (as we have done so much else) would it mean the end of species? Maybe in the long run, say in few thousands years, when we would be outcompeted by apes with superior mutations (IQ = 250) but that's not my top concern right now as my clock is ticking minutes and hours, not in thousands of years... Jurgen From owner-ageing@net.bio.net Sun Feb 02 22:00:00 1997 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.ageing Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 3 Feb 1997 02:00:11 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 239 Sender: daemon@net.bio.net Distribution: world Message-ID: <199702031000.CAA17862@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From owner-ageing@net.bio.net Wed Feb 05 22:00:00 1997 Path: biosci!agate!nntpfeed.doc.ic.ac.uk!sunsite.doc.ic.ac.uk!dundee.ac.uk!kbreenmac2 From: (k.c.breen@dundee.ac.uk) Newsgroups: bionet.molbio.ageing Subject: PhD Position Followup-To: bionet.molbio.ageing Date: 29 Jan 1997 19:56:13 GMT Organization: The University, Dundee, DD1 4HN, Scotland, UK. Lines: 23 Distribution: world Message-ID: <5coa0t$qc3@dux.dundee.ac.uk> NNTP-Posting-Host: kbreenmac2.medschool.dundee.ac.uk A collaborative studentship between Dr. Kieran Breen and SmithKline Beecham will be available from 1st October 1997 for the study of presenillin protein function. Mutations in this protein have been linked to the familial form of Alzheimer's disease and studies of its function may help to unravel the early events that occur in the disease process. This project will provide training in various experimental techniques including molecular biology and cell culture. Part of the project will be carried out at the SB Research Centre in Essex. Further details of the studentship may be obtained from Dr. Kieran Breen, Neurosciences Institute, Dept. of Pharmacology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, Scotland U.K. Applications, in the form of a current CV naming two referees, should also be sent to Dr. Breen. The closing date for applications is 28th February.To be eligible for the full award, applicants must comply with U.K. Home Office residence requirements. Kieran Breen, Dept. of Pharmacology, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY,Scotland, U.K. k.c.breen@dundee.ac.uk From owner-ageing@net.bio.net Wed Feb 05 22:00:00 1997 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!www.nntp.primenet.com!nntp.primenet.com!hunter.premier.net!feed1.news.erols.com!howland.erols.net!ix.netcom.com!netcom.net.uk!peer.news.u-net.net!news.u-net.com!wbains.u-net.com!user From: william@wbains.u-net.com (William Bains) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 6 Feb 1997 17:54:43 GMT Organization: Merlin Ventures Lines: 40 Distribution: world Message-ID: References: <32F3AC0C.31D8@njmug.org> NNTP-Posting-Host: wbains.u-net.com In article , Jurgen Kaljuvee wrote: > > A natural question arises: "If evolution has developed everything > imaginable, why hasn't it developed perfect repair systems?" > > To answer the question, consider the following thought experiment. > Suppose that several million years ago there was a species of, say, fish > that developed a perfect repair systems and as a result couls achieve a > lifespan that extended to several hundred or even thousands of years. > If so, why don't we see the species today? Where did it disappear? The > answer is that by attaining perfect repair system, the species lost the > capacity for mutation and variation and consequently for evolution. It > was soon outcompeted by a species which, though mortal on the individual > level, carried superior mutations as a species. Evolution presumes > variance, selection and mortality. > > So if human species developed perfect repair systems, not through > evolution, but artificially in a lab (as we have done so much else) would > it mean the end of species? Maybe in the long run, say in few thousands > years, when we would be outcompeted by apes with superior mutations (IQ = > 250) but that's not my top concern right now as my clock is ticking > minutes and hours, not in thousands of years... > Is this right? Aging is due to somatic errors - errors in the non-germ-cell tissues. Mutation is caused by changes in the germ cells. We could imagine an organism with perfect repair (including DNA repair) in the soma an organism could attain immortality, and still have a mutation system that applied to the germ cells, analagous to the directed mutation mechanism that generates variation in immunoglobulin gene variable regions. In reality, of course, 'perfect' repair requires an unlimited energy supply, and it is this trade-off between using energy for reproduction and for repair that means it is evolutionarily advantageous to age. -- William Bains From owner-ageing@net.bio.net Sat Feb 08 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!www.nntp.primenet.com!nntp.primenet.com!news.texas.net!news.stealth.net!uunet!in1.uu.net!194.119.128.129!news.u-net.com!newsmaster From: scott@aspex.u-net.com (c scott) Newsgroups: bionet.molbio.ageing Subject: no-aging diet Date: Sun, 09 Feb 1997 23:55:33 GMT Organization: U-NET Ltd Lines: 2 Message-ID: <5dlo39$g8u$1@despair.u-net.com> Reply-To: scott@aspex.u-net.com NNTP-Posting-Host: p5.ascend3.is2.u-net.net X-Newsreader: Forte Free Agent 1.0.82 can anyone send me a copy of Dr B. Frank's no-aging diet please? From owner-ageing@net.bio.net Sun Feb 09 22:00:00 1997 Path: biosci!UMABNET.AB.UMD.EDU!aandreye From: aandreye@UMABNET.AB.UMD.EDU ("Alexander Y. Andreyev") Newsgroups: bionet.molbio.ageing Subject: Courses on Aging and Longevity Date: 10 Feb 1997 09:48:38 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 158 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Dear Colleagues, Please find attached below the brief description of our University courses on Biodemography of Aging and Longevity for your information and comments. These courses are based on our book "The Biology of Life Span", on our seminars at Moscow State University, on our seminars we had recently in different parts of the United States: 1.University of Georgia, Athens, GA (Professor Poon). 2.University of Iowa, Ames, IA (Dr.Peter Martin). 3.University of Chicago (Dr.Brian Charlesworth and Dr.Jay Olshansky). 4.University of Wisconsin, Madison, WI (Professor James Crow). 5.University of Washington, Seattle (Dr.Walter Kukull). Additional recommendations could be obtained from Professor Robert Arking (Wayne State University), Professor Caleb Finch (UCLA) and from famous American demographer, Professor Nathan Keyfitz (now in Boston). If you are interested in the courses described below, please let us know by E-mail address mentioned above. Sincerely yours, Drs.Leonid and Natalia Gavrilov, Ph.D. ******************************************************************* BIODEMOGRAPHY OF AGING AND LONGEVITY (University courses) 1. Introduction 1.1. Why it is necessary to study life span. Fundamental importance and practical applications of aging and longevity studies. 1.2. Short history of the subject. Contributions of Christian Huygens, Gottfried Leibniz, Edmund Halley, Leonard Euler, Pierre Laplace, Karl Pearson, Benjamin Gompertz, William Makeham, Adolphe Quetelet and Raymond Pearl. 1.3. Present state of aging and longevity studies. Current status of life span studies in gerontology, demography, ecology, genetics, radiobiology, toxicology, oncology and zoology. 2. Individual Differences in Lifetime and Mortality Laws. (Different Biological Species). 2.1. Methods of life span studies. Life table and its functions. High variability of life span distribution. 2.2. Statistical methods of survival analysis. Survival Function and its Confidence Limits. Censoring. Planning of the Survival Studies. 2.3. Comparison of the Survival Curves. Statistical Tests. Mantel-Haenszel (Log-rank) test, Gehan-Breslow test and Kolmogorov-Smirnov test. Comparative analysis of different statistical tests. 2.4. In Search of the Mortality Law. Gompertz Law of Mortality. The problem of choosing the "correct" index of mortality. Analitical functions (laws) describing life span distribution. Methodological principles for selecting life span distribution law. Age-dependent and age- independent components of mortality. 2.5. Specific Behaviour of Mortality at Advanced Ages. Levelling-off of mortality rates at advanced ages: experimental evidence and possible explanations. 3. The Human Life Span. 3.1. Specific Questions Connected With Research Into the Human Life Span. Cohort versus cross-sectional approach. Historical Changes of Life Span in Developed Countries. 3.2. Demographic Life Table and Methods of its Construction. Current versus cohort life tables. Problem of estimation of life expectancy at advanced ages. 3.3. Mortality Indices Used in Demographic Studies. Standardized mortality rates, potential years of lofe lost, crude mortality rate. 3.4. Causes of Death and Methods of their Studying in Demography. Multiple-decrement and single-decrement life tables and indices derived from these tables. The problem of the diversity of causes of death and their interaction. 3.5. Regularities of Human Mortality. Mortality Laws Proposed for Description of Human Mortality. Biological and social characteristics of human life span. The historical stability of age-dependent component of human mortality. 3..6. The Epidemiological Approach to Studying the Biology of the Human Life Span. Brief Review of Main Factors that Have Influence on Human Life Span (Behavioral, Social, Environmental, Nutritional, Physiological, etc.). 3.7. Prospects for Human Life Span Extension. Population Aging and Its Causes. Different Approaches to Forecasting the Expected Number of Elderly people in United States. 4. Species-Specific Life Span and Centenarian Studies. 4.1. Review of Ideas about Species-Specific Life Span. Is there a Species-Specific Life Span Limit? Levelling-off of mortality rates at advanced ages. 4.2. The Strehler-Mildvan Correlation. Mortality Crossover Effect and Compensation Effect of Mortality. The Concept of Species- Specific Life Span Invariants. 4.3. Centenarian Studies and their Importance for Understanding the Mechanisms of Human Aging. Construction of life tables for advanced ages. Method of extinct generations. 4.4. Genealogical Studies of Familial Longevity. Mechanisms of Longevity Inheritance in Human Populations. Increased heritability of human longevity at advanced ages. 5. Possible Mechanisms Which Determine Life Span. 5.1. Brief Review of Existing Theories of Aging. Aging: a self-destruction program or wear and tear? 5.2. Evolutionary Approach to Aging Studies. Mutation accumulation theory of aging. Disposable soma theory of aging. 5.3. Analysis of Sex Differences in Lifetimes. Do females live longer than males? Sexually concordant and sexually inconcordant causes of death in humans. 5.4. Studies of Genes that Increase Longevity in Lower Organisms. Experimental data on nematodes, drosophila and yeast. 5.5. Experiments in Life Extension. Caloric restriction, hypothermia, antioxidants. "Signal-to-noise" ratio hypothesis. 5.6. The Limit of Cell Division. Its Relation to Aging of the Organism. Cell differentiation versus cell death. 5.7. Reliability Theory and Its Application to the Aging Studies. The concept of failure. Definition of aging in reliability theory. Basic parameters of reliability - stability, accuracy, speed of operations, loading characteristic. Comparison of biological and technical systems. 5.8. Mathematical Models of Life Span. Brief Review of Different Concepts. Mathematical Models of Aging Based on the Reliability Theory. Limiting distributions of the life spans of biological systems. The model of the avalanche-like destruction of an organism in natural aging. The model a multiply redundant system saturated with defects. The model of a redundant system with an arbitrary number of defects. The heterogeneous population model. The model of accumulation of defects with constant intensity of the flow damage. ****************************THE END************************************** From owner-ageing@net.bio.net Mon Feb 10 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!news-peer.gsl.net!news.gsl.net!news-paris.gsl.net!news.gsl.net!rain.fr!jussieu.fr!univ-angers.fr!ciril.fr!cnusc.fr!unice.fr!not-for-mail From: Terreux Raphael Newsgroups: bionet.molbio.ageing Subject: value of concentration in [catecholamines] Date: Tue, 11 Feb 1997 13:22:56 -0800 Organization: unsa - lartic Lines: 18 Message-ID: <3300E330.1CFB@chiminfo.unice.fr> NNTP-Posting-Host: chiminfo.unice.fr Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.01S (X11; I; IRIX64 6.2 IP28) Hello, I don't find in the litterature the value of the concentration of CATECHOLAMINES in ng/mg of protein in a rat's brain. If someone can help me Best regards. TERREUX Raphael, PhD Student -------------------------------------- LARTIC Universite de Nice-Sophia Antipolis, Parc Valrose, F 06108, Cedex 2, NICE, FRANCE TEL : +33 (0)4 92 07 61 26 TEL : +33 (0)4 92 07 60 60 poste 27 10 e-mail : TERREUX@CHIMINFO.UNICE.FR -------------------------------------- From owner-ageing@net.bio.net Mon Feb 10 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!www.nntp.primenet.com!nntp.primenet.com!howland.erols.net!usenet.kornet.nm.kr!newsfeed.dacom.co.kr!usenet.dacom.co.kr!not-for-mail From: Hang-Jun Chang Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: Tue, 11 Feb 1997 23:07:20 +0900 Organization: Dansan Public Health Center Lines: 42 Message-ID: <33007D18.7CE@chollian.dacom.co.kr> References: <32F3AC0C.31D8@njmug.org> NNTP-Posting-Host: 164.124.168.80 Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.0 (Win95; I) To: William Bains CC: iam@chollian.dacom.co.kr William Bains wrote: > > In article , > Jurgen Kaljuvee wrote: > > Is this right? Aging is due to somatic errors - errors in the > non-germ-cell tissues. Mutation is caused by changes in the germ cells. We > could imagine an organism with perfect repair (including DNA repair) in > the soma an organism could attain immortality, and still have a mutation > system that applied to the germ cells, analagous to the directed mutation > mechanism that generates variation in immunoglobulin gene variable > regions. > > In reality, of course, 'perfect' repair requires an unlimited energy > supply, and it is this trade-off between using energy for reproduction and > for repair that means it is evolutionarily advantageous to age. > > -- > William Bains Thank you William for your clear explanations. Disposable soma theory always sounds reasonable and plausible to me. But Inevitable questions arise from my curiosity as follows; 1. Would you like to let me know any experimental model to support or prove it? 2. If aging process arises from limited supply of energy or any life maintenance resource due to reproductive demant for it, What is energy or the life maintenance resource needed to maintain the Soma at all? If we find it out, isn't it possible for us to replace it in order to achieve immortality? I am very interested in the relationship between aging process and reproduction. Now calorie restriction is known as the only scientifically proved aging retardation method. If 'Disposable Soma' theory is correct, Why don't 'sexual or reproductive restraint' have any effect on life span? I don't know any scientific evident about it yet. If you know any articles on it, please let me know them. Hangjun Chang From owner-ageing@net.bio.net Mon Feb 10 22:00:00 1997 Path: biosci!ALUMNI.UBC.CA!BRowley From: BRowley@ALUMNI.UBC.CA (Longevity-Digest/ Brian Rowley) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 11 Feb 1997 12:58:20 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 24 Sender: daemon@net.bio.net Distribution: world Message-ID: <199702112057.MAA18834@unixg.ubc.ca> NNTP-Posting-Host: net.bio.net Hang-Jun Chang wrote: >I am very interested in the relationship between aging process and >reproduction. Now calorie restriction is known as the only >scientifically proved aging retardation method. If 'Disposable Soma' >theory is correct, Why don't 'sexual or reproductive restraint' have >any effect on life span? I don't know any scientific evident about it >yet. If you know any articles on it, please let me know them. > >Hangjun Chang > Reproduction decreases life span in fruit flies. Scientists who do mortality studies on fruit flies separate the males from the females to prevent mating, as mating reduces longevity. I don't think the same applies for humans, though :-> Brian Rowley/ Longevity Digest To subscribe to longevity-digest, a moderated, science-based E-mail group on ageing, send E-mail to listserv@vm.ege.edu.tr that reads: subscribe longevity-digest Bart Simpson in the text. From owner-ageing@net.bio.net Tue Feb 11 22:00:00 1997 Path: biosci!GNN.COM!DSchwa1234 From: DSchwa1234@GNN.COM (Douglas Schwartz) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 11 Feb 1997 17:58:45 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 77 Sender: daemon@net.bio.net Distribution: world Message-ID: <199702120158.UAA31000@mail-e2b.gnn.com> NNTP-Posting-Host: net.bio.net >Hang-Jun Chang wrote: >>I am very interested in the relationship between aging > process and >>reproduction. Now calorie restriction is known as the only >>scientifically proved aging retardation method. I should add that caloric intake is not only related to lifespan, buy also has strict relationships to reproduction rates as well (& that obviously lifespan & reproduction rates are integral determinants of population densities & that all this is very carefully regulated to maximize the survival odds for the species). Fast-breeders (such as mice) will immediately (within several days) witness the death of some of their numbers when fasted, and the rest will expire in a relatively short time (under a month). They do this to insure the survival of a few with the resulting then-increased caloric supply (due to less competition from their peers), and these surviving few will go on to rapidly regenerate the population once the food supply returns to normal. Slow-breeders (such as humans) take the opposite tack, & when fasted most will live for months in an effort to ride out the famine. >Brian Rowley wrote: > Reproduction decreases life span in fruit flies. Scien >tists who do >mortality studies on fruit flies separate the males from the > females to >prevent mating, as mating reduces longevity. I don't think the same applies >for humans, though :-> > >Brian Rowley/ Longevity Digest > Caloric-restricted human males will have markedly-diminished libido (dependent on the degree of restriction), while females tend to have increased libido when restricted. But since it takes two (or more) to tango, this means that reproduction will then not take place. Libidinous human males do indeed age at a rate much greater than the average. >To subscribe to longevity-digest, a moderated, science-based > E-mail group on >ageing, send E-mail to listserv@vm.ege.edu.tr that reads: >subscribe longevity-digest Bart Simpson > >in the text. > ***************************************************************** ~~~~~To subscribe to two uncensored, free-flowing venues dedicated to allowing ALL of us the free input of new, unfiltered ideas concerning human aging (& allowing each of us the opportunity to make up our OWN minds as to what we wish to read & what WE deem scientific or not), you can: A) send the following command in email to "biosci-server@net.bio.net": subscribe ageing Douglas Schwartz [which you have already done if you are reading this] OR B) send E-mail to listserv@vm.ege.edu.tr that reads: subscribe longevity Douglas Schwartz --Doug Schwartz dschwa1234@gnn.com From owner-ageing@net.bio.net Tue Feb 11 22:00:00 1997 Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!news.mel.connect.com.au!news.access.net.au!news.netspace.net.au!news.mel.aone.net.au!usenet From: Sohail Mohideen Newsgroups: bionet.molbio.ageing Subject: Alzheimer's Disease - A Carer's Guide Date: Wed, 12 Feb 1997 16:25:11 +1000 Organization: Health Communication Network Lines: 26 Message-ID: <33016247.5F01@hcn.net.au> Reply-To: sohail.mohideen@hcn.net.au NNTP-Posting-Host: d30-1.cpe.sydney.aone.net.au Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) Hi, I just thought I would inform you of a brilliant new publication which is available on the net. "Alzheimer's Disease - A Carer's Guide", is an informative and compassionate book which helps carers of alzheimer's disease come to grips with the burden of looking after a loved who is afflicted by this illness. It provides an in-depth discussion of the stages of this illness, their various causes, symptoms and how to deal with them. The book has an interesting blend of both compassion and practicality, the two main features which are essential in effectively caring for someone with this unfortunate disease. The cost of the book is A$7.95 and is available both on-line and in its paper version. For more information on this book, there is a contents page at: http://www.hcn.net.au/healthworks/contents/alzheimer.htm To read the blurb for this publication, one can go to: http://www.hcn.net.au/healthbooks/mental.htm#alzheimers Hope this information is of some use. Wishing you all the best, Sohail Mohideen From owner-ageing@net.bio.net Wed Feb 12 22:00:00 1997 Path: biosci!VOICENET.COM!levin1 From: levin1@VOICENET.COM (Larry Levin) Newsgroups: bionet.molbio.ageing Subject: a conference on aging Date: 13 Feb 1997 07:05:42 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 75 Sender: daemon@net.bio.net Distribution: world Message-ID: <33036757.1AA6@voicenet.com> NNTP-Posting-Host: net.bio.net World Affairs Council of Philadelphia and CIGNA present COMING OF AGE The Economic and Political Implications of an Aging Society featuring PAUL VOLCKER, former Chairman, Federal Reserve Board and RAY SUAREZ, Host, National Public Radio¹s The Talk of the Nation Thursday, April 3, 1997 Wyndham Franklin Plaza Hotel 17th & Race Streets Philadelphia Full Conference $140 (11:15am - 9:00pm includes lunch and dinner) Dinner & Keynote address: Paul Volcker $70 Luncheon & Beyond Tomorrow Panel $65 with panel discussions on . . . Beyond Tomorrow: Achieving Individual Financial Security and National Economic Well-Being Topic: The shift in U.S. demographics and its impact on retirement policy, roles of public and private sector Merging Our Interests: A New Paradigm for an Aging Society Topic: The differing perspectives, as well as common goals, of various groups in society A Bird¹s Eye View of Global Graying Topic: The demographic changes in countries other than the U.S. and their approaches to retirement policy The Council is also grateful to the following companies for their support: Towers Perrin, Drake Beam Morin, Inc., CoreStates, N.A., and Thomas Jefferson University. To obtain a refund, cancellation must be received three working days prior to program. Please return this form to: World Affairs Council of Philadelphia tel: 1314 Chestnut Street Philadelphia, PA 19107 215/731-1100 fax: 215/731-1111 e-mail: wac@libertynet.org Name(s) _____________________________________________ Day Phone __________________________ Address ______________________________________ City ______________ State _____ Zip ___________ I would like _______ reservation(s) at $ _______ per person. Enclosed is my payment for $ ______. Payment is made with ______ VISA _______ MasterCard Expiration date __________________ Card Number ____________________________________ Signature _________________________________ From owner-ageing@net.bio.net Thu Feb 13 22:00:00 1997 Path: biosci!CORNELL.EDU!dnw1 From: dnw1@CORNELL.EDU (David Wald) Newsgroups: bionet.molbio.ageing Subject: graduate schools Date: 13 Feb 1997 21:04:05 -0800 Organization: Cornell University Lines: 5 Sender: daemon@net.bio.net Distribution: world Message-ID: <3303F199.546F@cornell.edu> NNTP-Posting-Host: net.bio.net I am currently applying to graduate programs to study the biomolecular causes of aging. I was wondering if anyone could recommend any schools or researchers for me. Thanks, Dave Wall From owner-ageing@net.bio.net Fri Feb 14 22:00:00 1997 Path: biosci!agate!howland.erols.net!feed1.news.erols.com!news.magicnet.net!not-for-mail From: Gary Newsgroups: bionet.molbio.ageing Subject: Zone Balanced Nutrition Information Date: Sat, 15 Feb 1997 12:21:38 -0500 Organization: Better Health through Science Lines: 7 Message-ID: <3305F0A2.488D@aol.com> Reply-To: GaryM39@aol.com NNTP-Posting-Host: orlic.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0Gold (Macintosh; I; 68K) We have information available on Zone Balanced Nutrition. Please contact GaryM39@aol.com to request additional data or to answer any questions about Zone Balanced Nutrition. http://www.orlic.com/ Gary From owner-ageing@net.bio.net Sat Feb 15 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!chi-news.cic.net!compuserve.com!news.production.compuserve.com!news From: John Leslie <74740.247@CompuServe.COM> Newsgroups: bionet.metabolic-reg,bionet.microbiology,bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank Subject: Radio/TV guests needed Date: 16 Feb 1997 19:18:13 GMT Organization: World Radio Inc. Lines: 26 Message-ID: <5e7mhl$pn9$5@mhafc.production.compuserve.com> Xref: biosci bionet.metabolic-reg:1054 bionet.microbiology:8927 bionet.molbio.ageing:3209 bionet.molbio.bio-matrix:856 bionet.molbio.embldatabank:770 Millions of people will hear you discuss your business, product, corporation, interest, hobby, religious or scientific view, web page or political opionion on radio and television stations all over the world. Each week, "World Radio Inc." distributes a list of names of people and companies willing to appear "on the air" to hundreds of local and network radio and television stations. Producers and hosts of talk and interview shows are frantic to find people who can discuss every aspect of life, business, politics, life styles, science, technology and leasure time. Included on our distribution list ar programs like "Larry King Live" "Oprah" "Sally Jesse Raphael" and many others. It is sent to "The Radio Television News Directions Association" "The National Association of Talk Show Hosts" "Talkers Magazine" "The National Association of Broadcasters" "CBS" "NBC" "ABC" "CNN" as well as hundreds of local radio and television stations nationwide. The list is called "Media GuestNet" and is also sent provided weekly to broadcast stations and networks all over eastern and western Europe. We have an exclusive contract with the english speaking Russian National Radio System. This could be your chance to tell millions of people about your product or area of expertise. For more information please send e-mail to jleslie@spectra.net as soon as possible. We also produce and syndicate "World Radio Saturday, "World Radio News". -- Jan L Kokochak From owner-ageing@net.bio.net Sat Feb 15 22:00:00 1997 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Re: Progeria Date: 16 Feb 1997 05:16:54 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 17 Sender: daemon@net.bio.net Distribution: world Message-ID: References: NNTP-Posting-Host: net.bio.net We are interested in 'Antigeria' the medical condition of profoundly extended youth, not early aging. What is the scientific term for cellular immortality? What is the lay term? On Sat, 15 Feb 1997, Bethany Henderson wrote: > I'm a junior Biology major at Heidelberg College. I would like to recieve > information about Progeria. Any information would be of great help. > Thank you. > > "Accept the things that you can not change." > > > From owner-ageing@net.bio.net Sat Feb 15 22:00:00 1997 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Re: Antigeria Date: 16 Feb 1997 13:02:36 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 47 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <33076E21.2882@bigfoot.com> NNTP-Posting-Host: net.bio.net On Sun, 16 Feb 1997, Dawn wrote: > Ah, so it is a non-existent condition? Just wondering, as I'm in that > field and have never actually heard about ANTIGERIA > I did not say it was non-existent. That can not be proved or disproved. It just hasn't been reported to the general media yet. With billions of dollars at stake, why would someone give it away? There are several good reasons to keep the lid on something like the anti-geron. ("Trouble With Lichen" - a fictional account of such a discovery). Getting 'close' to discovering (developing) a technique to stop the aging process is good enough to announce to the media. Funding, fame and support would result. 'Close' is not the same thing as 'there', however, and any laboratory, corporation, university, or individual who breaks through 'close' and actually gets 'there' will want more than fame. There's world power at stake, among other ramifications. If you could extend an organism's life expectancy from 20 days to 2 years, would you go public with it? Going from 20 days to 30 or 40 days would get publicity and an extension of current funding. Going from 20 days to 2 years would bring problems we may not be prepared to face. Would you publish success in alchemy? Go back thru the archives and abstracts of biotechnology journals and e-mail lists for the last 3 years and see how many people were publishing their 'close' findings and then all of a sudden, you never hear from them or read about their new progress. How much of their early contributions was purged? Don -- > -Dawn- > Visit: http://members.aol.com/CappSci > ...Because the alternative is not logical. > From owner-ageing@net.bio.net Sat Feb 15 22:00:00 1997 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Antigeria Date: 16 Feb 1997 12:00:48 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 39 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <33075CD6.77FC@bigfoot.com> NNTP-Posting-Host: net.bio.net > > We are interested in 'Antigeria' the medical condition of profoundly > > extended youth, not early aging. > > Please explain Antigeria to me? I've never heard about the condition. Antigeria is a medical condition that I would like to have. It means perpetual youth. It is a term that I coined for lack of a better one. It is a condition that Geron Corp (NASDAQ) is seeking to develop. There is a biotechnical term for it. A4M is a coalition of scientists working to lengthen human life expectancy. Many researchers globally are seeking ways to stop the aging process (eg., Curing the Old Age Disease Society - COADS). Breakthru would be worth $billions in windfall profits. Then, again, if I were a scientist who discovered the way to stay young and stop the aging process, I don't know if I would let the world know about it for many years to come. The ramifications are incomprehensible. I'm not sure that it hasn't already been developed. Govt's have a way of suppressing research or solutions. Even with the cellular aging process arrested, people would still have opportunites to extinguish themselves in socially acceptable ways, such as overconsumption of foods; regular ingestion of toxins like alcohol, smoke, fatty foods, and high cholesterols; sedentary lifestyles; as well as careless driving and going to high crime areas and participating in high-risk activities. Don (not Dawn) > -- > -Dawn- > Visit: http://members.aol.com/CappSci > ...Because the alternative is not logical. > From owner-ageing@net.bio.net Sat Feb 15 22:00:00 1997 Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!news.ecn.uoknor.edu!news.ysu.edu!odin.oar.net!malgudi.oar.net!nike.heidelberg.edu!nike!bhenders From: Bethany Henderson Newsgroups: bionet.molbio.ageing Subject: Progeria Date: Sat, 15 Feb 1997 18:01:24 -0500 Organization: Heidelberg College Lines: 6 Message-ID: NNTP-Posting-Host: nike.heidelberg.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Sender: bhenders@nike I'm a junior Biology major at Heidelberg College. I would like to recieve information about Progeria. Any information would be of great help. Thank you. "Accept the things that you can not change." From owner-ageing@net.bio.net Sun Feb 16 22:00:00 1997 Path: biosci!GNN.COM!DSchwa1234 From: DSchwa1234@GNN.COM (Douglas Schwartz) Newsgroups: bionet.molbio.ageing Subject: Re: Progeria Date: 16 Feb 1997 20:24:25 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 8 Sender: daemon@net.bio.net Distribution: world Message-ID: <199702170424.XAA18672@mail-e2b.gnn.com> NNTP-Posting-Host: net.bio.net >What is the scientific term for cellular immortality? Valhalla, Heaven or Shangra La, take your pick. --Doug Schwartz dschwa1234@gnn.com From owner-ageing@net.bio.net Sun Feb 16 22:00:00 1997 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Re: Antigeria Date: 16 Feb 1997 21:34:14 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 20 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <33078191.6874@bigfoot.com> NNTP-Posting-Host: net.bio.net On Sun, 16 Feb 1997, Dawn wrote: > Yes, to answer your question, if I found the "cure to aging", I would > announce it. Scientific Knowledge - especially that with life-saving > applications - belongs to everyone. > > And, being a researcher in the field, I can assure you that we haven't > found the cure to aging yet. Who is 'we'? Is that your institution? Or do you speak for all scientists universally? > -- > -Dawn- > Visit: http://members.aol.com/CappSci > Time is the best teacher. > Unfortunately, it kills all of its students. > From owner-ageing@net.bio.net Sun Feb 16 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!newsfeeds.sol.net!newspump.sol.net!howland.erols.net!rill.news.pipex.net!pipex!uunet!in3.uu.net!199.184.165.2!news.interport.net!interport.net!rugosa From: rosaphil Newsgroups: alt.romance.mature-adult,bionet.molbio.ageing Subject: Students, Unite! (fwd) Date: Mon, 17 Feb 1997 18:09:27 -0500 Organization: Interport Communications Corp. Lines: 209 Message-ID: NNTP-Posting-Host: madison.interport.net Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII To: "L-Soft list server at MIZZOU1 (1.8b)" , CLUBMAIL +********** Snail me yer rosehips if you liked this post! ************ + GABRIELLI WINERY (Mendocino,CA): Zinfandel, Ascenza (White-Blend), + + Pinot-Noir, Sangiovenese Grapes--Yummy! + *Better Living Thru Better Living!* http://www.interport.net/~rugosa * ---------- Forwarded message ---------- Date: Sun, 16 Feb 1997 14:41:34 +0000 From: "Dr. Ruben Botello" To: AHS-L@AMERICAN.EDU Subject: Students, Unite! ----------------------------------------------------------------- *PLEASE FORWARD* revised: 2/7/97 Dear Students and Faculty Members: Congress and the President have begun to wake up on budget priorities! Some of the worst Republican student-aid cuts were reversed in October by Congress, and the President yesterday proposed the first significant increases in education and housing spending in over a decade! However, rather then get the money from parts of the budget where there is plenty of fat to cut, politicians are planning raids on entitlement programs, such as Medicare and Social Security -- pitting the interests of young and homeless people against elderly folks. There is no need for this. The United States, as the richest country in the world, has the resources to provide basic income security to those of us facing harsh economic trends. If we cut $125 billion from corporate welfare, cut $75 billion from military forces we no longer need, and tax the windfall a few are receiving from corporate downsizing, our government would run a surplus. Yet the rejoinder we hear time and time again is that we need to make deep cuts in social programs in order to "balance the budget." For this reason, the Center for Campus Organizing, the Student Peace Action Network, the US Student Association, Youth for Democratic Action, 20/20 Vision, Women's Action for New Directions, the Campaign for New Priorities, and over 20 grassroots peace and justice groups on college campuses have joined together to circulate a "Petition for New Priorities." We ask you to join in this effort. All it takes is a group with 5 or six people to stand in a public place for two or three days near lunchtime to collect signatures. Then, you can use the support you find to generate some publicity which will put heat on local politicians to support balanced budget priorities. For example, you can ask your local Congressperson to sign the petition; if he or she refuses then you can raise public awareness about how they have sold out to corporate interests. Here are the schools involved so far. To get your petition kit, please call 617-354-9363 or send e-mail to rcowan@lesley.edu. Thanks!! Schools (as of 2/3/96) American University Antioch College Brandeis University Clark University College of Wooster, OH Cornell University Marquette University, WI Penn State University Purdue University RIT St. Cloud St. University St. John Fisher College St. Peters College University of Colorado University Incarnate Word University of New Mexico University of Pennsylvania University of Vermont Xavier University ------------------- to get a clean copy with lots of informative posters and fact sheets, send e-mail to rcowan@lesley.edu Petition for New Priorities We, the undersigned, are distressed that the government is making cuts in important social programs in order to "balance the budget." The greatest obstacle to balancing the budget is the $400 billion spent each year on the military and on corporate welfare. (see details on reverse) We urge President Clinton and all representatives in Congress to make cuts in military spending and corporate subsidies to pay for new priorities that place greater value on education, environmental protection, and human welfare. We support congressional proposals to redirect military spending and corporate welfare to social spending. We pledge to give our votes and our time to candidates who pledge to support these new priorities. SIGNATURE PRINTED NAME & ADDRESS 1. ___________________ __________________________________________________ 2. ___________________ __________________________________________________ 3. ___________________ __________________________________________________ 4. ___________________ __________________________________________________ 5. ___________________ __________________________________________________ 6. ___________________ __________________________________________________ 7. ___________________ __________________________________________________ 8. ___________________ __________________________________________________ 9. ___________________ __________________________________________________ 10. __________________ __________________________________________________ 11. __________________ __________________________________________________ 12. __________________ __________________________________________________ 13. __________________ __________________________________________________ 14. __________________ __________________________________________________ 15. __________________ __________________________________________________ When returned to the group listed below, completed petitions will be delivered to local representatives, to President Clinton, and to the newsmedia: (page 2) "Petition for New Priorities" - Background Info In the last two years, the U.S. Congress has tried to cut billions of dollars from domestic programs like welfare, student aid, and enforcing environmental laws1 while preserving $150 billion in corporate welfare.2 Politicians have said that we must "make sacrifices" in order to reduce the deficit.3 However, these three domestic programs together amount to less than one-quarter of the military budget, which has been spared from cuts.4 We now spend over $260 billion in tax dollars every year on the military, including nuclear weapons programs.5 Even though the Cold War ended 7 years ago, we spend 90% as much on the military now as we did from 1950-1990.6 Many respected military analysts have detailed how the Pentagon could cut spending by up to 50% and still meet U.S. national security needs.7 We spend 17 times the combined military budgets of all potential adversaries.8 By spreading U.S.-made arms all over the world, we may actually increase the potential for war.9 In October of 1996, the Congress and the President approved a 1997 military budget with $9.4 billion more than the Pentagon requested.10 1 Information on attempted cuts was provided by the U.S. House Budget Committee in its original budget proposals for FY 1996 and FY 1997, available at the committee Web site (www.house.gov). The cuts which passed were much smaller than those proposed, due to vetos from President Clinton in the fall of 1995. 2 The Boston Globe estimates Corporate Welfare at $150 billion per year. Their series is located at http://www.envirolink.org/issues/corporate/welfare. Thd National Commission for Economic Conversion and Disarmament in Washington, DC published a report entitled "Pentagon Corporate Welfare" estimating the portion corporate welfare in the military budget to be $10 billion, so non-Pentagon corporate welfare is about $140 billion. 3 For example, Newt Gingrich was quoted in the Boston Globe on February 3, 1995 as saying that students receiving Pell grants were not doing their part to reduce the deficit. 4 The figures for these three programs: Welfare (AFDC): about $25 billion in 1994-5 [Statistical Abstract of the U.S.] Student Aid: $32.7 billion in 1994-5 [Chronicle of Higher Education] Environmental Protection Agency: $6.3 billion in 1995 [Statistical Abstract of the U.S.] Total for Welfare, Student Aid, EPA: $64 billion Four times this figure is $256 billion, still less than the 1996 military budget of $265.6 billion. 5 Gray, Jerry, "Senate Approves a Big Budget Bill, Beating Deadline," New York Times, October 1, 1996, p. 1. 6 Derived from "U.S. Military Spending, 1945-1996," fact sheet by Martin Calhoun, Center for Defense Information, April 2, 1996. Includes spending on nuclear weapons programs by the US Dept. of Energy. 7 See Korb, Lawrence, former Asst. Secretary of Defense in the Reagan Administration, in "Our Overstuffed Armed Forces," Foreign Affairs, November/December 1995; also America's Defense Monitor, interview with William Colby. 8 In 1991, General Colin Powell was quoted, "We no longer have the luxury of having a threat to plan for." Below are the military budgets of all the countries the Pentagon defines as potential adversaries, as listed in the report World Military Expenditures and Arms Transfers, US Arms Control and Disarmament Agency, 1996: Iraq 3 billion Syria 3 billion Libya 1 billion Cuba 0.3 billion North Korea 6 billion Iran 2 billion Total : $15.6 billion Multiplied by 17, this comes to $265.2 billion, still less than the United States military budget. 9 "Armed for Profit," The Boston Globe, special 12-page report. Feb. 11, 1996. 10 "Highlights: The Senate's Bill for Fiscal '97," New York Times, October 1, 1996, chart on p.22. From owner-ageing@net.bio.net Tue Feb 18 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!csulb.edu!hammer.uoregon.edu!news.texoma.net!zephyr.texoma.net!uunet!in1.uu.net!152.163.170.17!newstf01.news.aol.com!audrey01.news.aol.com!not-for-mail From: okeeone@aol.com (Okeeone) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 19 Feb 1997 20:19:24 GMT Organization: AOL http://www.aol.com Lines: 12 Message-ID: <19970219133500.IAA11825@ladder01.news.aol.com> References: <199702120158.UAA31000@mail-e2b.gnn.com> NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com On 11 Feb 1997 Douglas Schwartz wrote: >Caloric-restricted human males will have markedly-diminished libido >(dependent on the degree of restriction), while females tend to have >increased libido when restricted. But since it takes two (or more) >to tango, this means that reproduction will then not take place. >Libidinous human males do indeed age at a rate much greater than the >average. Wow. Could you say more about this and site you sources? Matt O'Connor From owner-ageing@net.bio.net Tue Feb 18 22:00:00 1997 Path: biosci!bcm.tmc.edu!cs.utexas.edu!swrinde!howland.erols.net!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in2.uu.net!152.163.170.17!newstf01.news.aol.com!audrey02.news.aol.com!not-for-mail From: okeeone@aol.com (Okeeone) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 19 Feb 1997 23:43:53 GMT Organization: AOL http://www.aol.com Lines: 12 Message-ID: <19970219134500.IAA16918@ladder01.news.aol.com> References: <199702120158.UAA31000@mail-e2b.gnn.com> NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com On 11 Feb 1997 Douglas Schwartz wrote: >Caloric-restricted human males will have markedly-diminished libido >(dependent on the degree of restriction), while females tend to have >increased libido when restricted. But since it takes two (or more) >to tango, this means that reproduction will then not take place. >Libidinous human males do indeed age at a rate much greater than the >average. Wow. Could you say more about this and site you sources? Matt O'Connor From owner-ageing@net.bio.net Tue Feb 18 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!csulb.edu!hammer.uoregon.edu!news.texoma.net!zephyr.texoma.net!hunter.premier.net!newsfeeds.sol.net!news.maxwell.syr.edu!cpk-news-hub1.bbnplanet.com!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in2.uu.net!38.8.16.2!psinntp!iris.rfmh.org!mhpertg Organization: Integrated Research Information Systems Date: Wed, 19 Feb 1997 15:29:46 EST From: Message-ID: <97050.152946MHPERTG@iris.rfmh.org> Newsgroups: bionet.molbio.ageing Subject: Smoking and Smoke interactions with medications Distribution: world References: Lines: 3 I am interested in bibliographic information on smoke cessation and smoke interactions with especially psychotropid medications. Thanks. From owner-ageing@net.bio.net Tue Feb 18 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!howland.erols.net!EU.net!newsfeed.internetmci.com!news.magg.net!news.bridge.net!uunet!in2.uu.net!38.8.16.2!psinntp!iris.rfmh.org!mhpertg Organization: Integrated Research Information Systems Date: Wed, 19 Feb 1997 15:28:59 EST From: Message-ID: <97050.152859MHPERTG@iris.rfmh.org> Newsgroups: bionet.molbio.ageing Subject: Re: Courses on Aging and Longevity Distribution: world References: Lines: 0 11 From owner-ageing@net.bio.net Tue Feb 18 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!cs.utexas.edu!howland.erols.net!newsxfer.itd.umich.edu!uunet!in3.uu.net!192.174.65.41!01-newsfeed.univie.ac.at!03-newsfeed.univie.ac.at!sbg.ac.at!news From: Reinhard Nestelbacher Newsgroups: bionet.molbio.ageing Subject: ageing-websites Date: Sat, 15 Feb 1997 15:58:52 +0100 Organization: University of Salzburg; Inst. of Genetics and General Biology Lines: 3 Message-ID: <3305CF2C.4053@sbg.ac.at> Reply-To: reinhard.nestelbacher@sbg.ac.at NNTP-Posting-Host: dgen38.gen.sbg.ac.at Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.01 (Win95; I) Hallo All! who knows a list of web addresses which handles the topic Aging? From owner-ageing@net.bio.net Tue Feb 18 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!csulb.edu!hammer.uoregon.edu!arclight.uoregon.edu!su-news-hub1.bbnplanet.com!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!howland.erols.net!news3.cac.psu.edu!news.cse.psu.edu!news.ece.nwu.edu!newsfeed.acns.nwu.edu!news.cc.uic.edu!uicvm.uic.edu!u56375 Organization: University of Illinois at Chicago, ADN Computer Center Date: Mon, 17 Feb 1997 13:30:08 CST From: Message-ID: <97048.133008U56375@uicvm.uic.edu> Newsgroups: bionet.molbio.ageing Subject: Biology Research Position Lines: 10 Postdoctoral Research Associateship Qualifications: PhD or equivalent with experience in molecular immunology (flow cytometry, quantitative PCR, cytokines, etc.) Send CV, reprints to: Dr. R. Krishnara Department of Medicine (M/C 787) UIC College of Medicine 840 South Wood Street Chicago, IL 60612 Fax: 312-413-2693 From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!ihnp4.ucsd.edu!swrinde!cs.utexas.edu!news.tamu.edu!news From: Dawn Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: Wed, 19 Feb 1997 19:14:47 -0600 Organization: Texas A&M University, College of Medicine, Dept of Medical Biochemistry and Genetics Lines: 25 Message-ID: <330BA587.2E6F@bigfoot.com> References: <199702120158.UAA31000@mail-e2b.gnn.com> <19970219134500.IAA16918@ladder01.news.aol.com> Reply-To: DawnC@bigfoot.com NNTP-Posting-Host: modem-0690.rns.tamu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) Okeeone wrote: > > On 11 Feb 1997 Douglas Schwartz wrote: > > >Caloric-restricted human males will have markedly-diminished libido > >(dependent on the degree of restriction), while females tend to have > >increased libido when restricted. But since it takes two (or more) > >to tango, this means that reproduction will then not take place. > >Libidinous human males do indeed age at a rate much greater than the > >average. > > Wow. Could you say more about this and site you sources? > > Matt O'Connor Somehow, I think, even with a decrease LIBIDO, human males will still want to "tango." It's like taking away a few drops from an ocean - there'd still be plenty left. -- -Dawn- Visit: http://members.aol.com/CappSci Time is the best teacher. Unfortunately, it kills all of its students. From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!howland.erols.net!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in2.uu.net!152.163.170.17!newstf01.news.aol.com!audrey02.news.aol.com!not-for-mail From: okeeone@aol.com (Okeeone) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 20 Feb 1997 01:28:44 GMT Organization: AOL http://www.aol.com Lines: 12 Message-ID: <19970219145500.JAA07873@ladder01.news.aol.com> References: <199702120158.UAA31000@mail-e2b.gnn.com> NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com On 11 Feb 1997 Douglas Schwartz wrote: >Caloric-restricted human males will have markedly-diminished libido >(dependent on the degree of restriction), while females tend to have >increased libido when restricted. But since it takes two (or more) >to tango, this means that reproduction will then not take place. >Libidinous human males do indeed age at a rate much greater than the >average. Wow. Could you say more about this and site you sources? Matt O'Connor From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!cs.utexas.edu!howland.erols.net!cam-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!news.sprintlink.net!news-peer.sprintlink.net!news-pull.sprintlink.net!news.sprintlink.net!news-dc-9.sprintlink.net!rill.news.pipex.net!pipex!btnet!btnet-feed1!BTInternet!usenet From: George Mason Newsgroups: bionet.molbio.ageing Subject: Computer/mathematical models of ageing Date: Thu, 20 Feb 1997 15:07:54 +0000 Organization: BT Internet Lines: 9 Message-ID: <330C68CA.4A96@btinternet.com> NNTP-Posting-Host: host-73-37-58.btinternet.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0 (Win95; I) Does anyone know of newsgroups, papers or web pages on computer (or conceptual) models of ageing in humans or animals. I'm trying to write a computer model of dog ageing (health, nutrition etc.) and don't really know where to start. Sorry the area's a bit vague but I'll appreciate any help or advice. Richard From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!howland.erols.net!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in2.uu.net!194.119.128.129!news.u-net.com!wbains.u-net.com!user From: william@wbains.u-net.com (William Bains) Newsgroups: bionet.metabolic-reg,bionet.microbiology,bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank Subject: Re: Radio/TV guests needed Date: 20 Feb 1997 22:19:28 GMT Organization: Merlin Ventures Lines: 23 Message-ID: References: <5e7mhl$pn9$5@mhafc.production.compuserve.com> NNTP-Posting-Host: wbains.u-net.com Xref: biosci bionet.metabolic-reg:1058 bionet.microbiology:9001 bionet.molbio.ageing:3226 bionet.molbio.bio-matrix:857 bionet.molbio.embldatabank:772 In article <5e7mhl$pn9$5@mhafc.production.compuserve.com>, John Leslie <74740.247@CompuServe.COM> wrote: > Millions of people will hear you discuss your business, product, > corporation, interest, hobby, religious or scientific view, web > page or political opionion on radio and television stations all > over the world. Each week, "World Radio Inc." distributes a list > of names of people and companies willing to appear "on the air" to > hundreds of local and network radio and television stations. > Producers and hosts of talk and interview shows are frantic could be > your chance to tell millions of people about your product or area > of expertise. For more information please send e-mail to > jleslie@spectra.net as soon as possible. We also produce and > syndicate "World Radio Saturday, "World Radio News". > > -- > Jan L Kokochak This is an appeal for US companies etc., I suppose. Please remember that more than 50% of internet users are not US citizens. -- William Bains From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!GNN.COM!DSchwa1234 From: DSchwa1234@GNN.COM (Douglas Schwartz) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 20 Feb 1997 15:32:12 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 34 Sender: daemon@net.bio.net Distribution: world Message-ID: <199702202332.SAA13978@mail-e2b.gnn.com> NNTP-Posting-Host: net.bio.net >From: okeeone@aol.com (Okeeone) > >On 11 Feb 1997 Douglas Schwartz wrote: > >>Caloric-restricted human males will have markedly-diminished > libido >>(dependent on the degree of restriction), while females tend > to have >>increased libido when restricted. But since it takes two > (or more) >>to tango, this means that reproduction will then not take pla >ce. >>Libidinous human males do indeed age at a rate much greater > than the >>average. > >Wow. Could you say more about this and site you sources? Those of us caloric restricted males don't need much of a source to know this. You might want to look at Ancel Keys' WWII work on human starvation experiments, some might be in there. The female part can be confirmed in one of Soltzhenitzen's (sp?) Gulag memoirs. And to also respond to a subsequent post about not believing that males will cease reproduction because of this, there may still be the will, but if the way is non-functional, the tango won't be consummated. Believe it or not males CAN be housebroken, but you just can't feed them for a while if you want to be successful. --Doug Schwartz dschwa1234@gnn.com From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!arclight.uoregon.edu!su-news-hub1.bbnplanet.com!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in2.uu.net!194.119.128.129!news.u-net.com!wbains.u-net.com!user From: william@wbains.u-net.com (William Bains) Newsgroups: bionet.molbio.ageing Subject: Re: Antigeria Date: 20 Feb 1997 22:18:10 GMT Organization: Merlin Ventures Lines: 24 Distribution: world Message-ID: References: <33078191.6874@bigfoot.com> NNTP-Posting-Host: wbains.u-net.com In article , dashley@TENET.EDU (Don Ashley) wrote: > On Sun, 16 Feb 1997, Dawn wrote: > > > Yes, to answer your question, if I found the "cure to aging", I would > > announce it. Scientific Knowledge - especially that with life-saving > > applications - belongs to everyone. Right, that is why the patent system exists, I suppose? In reality, we will not discover 'the' cure for ageing, any more than 40 years of molecular genetics has discovered 'the' cure for cancer. There will be a battery of techniques, each extending life and youthfulness by a few percent, maybe 30% for a really hot technique. And everyone will announce their technique because, after all, it will only be an incremental improvement. Like each new generation of PC is just a slight upgrade on teh last, none are really revolutionary, none are going to alter society fundamentally, but here we are after 20 years and suddenly society is fundamentally different, thanks to the PC. -- William Bains From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!csulb.edu!hammer.uoregon.edu!xfer.kren.nm.kr!usenet.kornet.nm.kr!howland.erols.net!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in2.uu.net!194.119.128.129!news.u-net.com!wbains.u-net.com!user From: william@wbains.u-net.com (William Bains) Newsgroups: bionet.molbio.ageing Subject: Re: Where are the perfect repair systems? Date: 20 Feb 1997 22:23:51 GMT Organization: Merlin Ventures Lines: 26 Message-ID: References: <199702120158.UAA31000@mail-e2b.gnn.com> <19970219133500.IAA11825@ladder01.news.aol.com> NNTP-Posting-Host: wbains.u-net.com In article <19970219133500.IAA11825@ladder01.news.aol.com>, okeeone@aol.com (Okeeone) wrote: > On 11 Feb 1997 Douglas Schwartz wrote: > > >Libidinous human males do indeed age at a rate much greater than the > >average. I do not believe this. Lustful males may age faster, due to stress, tendency to get drunk too much, drive fast cars to impress etc.. But it is well established that married males live longer than single ones, and married males (on average) get more regular and more frequent sex than singles. Married females live shorter, but this is believed to be mainly due to the stresses of pregnancy. Presumably if you separated them into childless- and child-bearing groups, the childless group could well be longer lived. It is known that the nematode worm c.elegans' life expectancy is reduced by having sex (males), but there are probably evolutionary reasons for this, like there are for the Pacific salmon dying once it has swum up river and ferilised the eggs. -- William Bains From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!agate!howland.erols.net!worldnet.att.net!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.molbio.ageing Subject: Re: ageing-websites Date: Thu, 20 Feb 1997 17:54:35 GMT Organization: MindSpring Enterprises, Inc. Lines: 13 Message-ID: <5ei3dh$kd3@camel2.mindspring.com> References: <3305CF2C.4053@sbg.ac.at> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip35.an9-new-york4.ny.pub-ip.psi.net X-Server-Date: 20 Feb 1997 17:59:13 GMT X-Newsreader: Forte Free Agent 1.0.82 There is a fairly extensive list at the Gerontological Soc. of America website (http://www.geron.org) Reinhard Nestelbacher wrote: >Hallo All! >who knows a list of web addresses which handles the topic Aging? Richard A. Lockshin (lockshin@mindspring.com;lockshin@sjumusic.stjohns.edu) check out Cell Death Soc web page: http://rdz.stjohns.edu/~lockshin/index.html From owner-ageing@net.bio.net Wed Feb 19 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!csulb.edu!hammer.uoregon.edu!xfer.kren.nm.kr!usenet.kornet.nm.kr!howland.erols.net!rill.news.pipex.net!pipex!uunet!in3.uu.net!194.119.128.129!news.u-net.com!wbains.u-net.com!user From: william@wbains.u-net.com (William Bains) Newsgroups: bionet.general,bionet.molbio.ageing Subject: Hair colour and ageing Date: 20 Feb 1997 21:52:10 GMT Organization: Merlin Ventures Lines: 12 Message-ID: NNTP-Posting-Host: wbains.u-net.com Xref: biosci bionet.general:25712 bionet.molbio.ageing:3225 Can anyone suggest a source for data on the rate at which hair goes white on experimental animals? Most mammals' hair goes white 'hair-at-a-time' rather than all hairs fading gradually, and it should be quite easy (if tedious) to measure the fraction of white hairs on an otherwise dark-haired mouse or rabbit. Has anyone done this? References? Thanks. William Bains -- William Bains From owner-ageing@net.bio.net Sun Feb 23 22:00:00 1997 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.clark.net!cpk-news-hub1.bbnplanet.com!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!uunet!in1.uu.net!204.96.36.2!wizard.pn.com!news.xensei.com!news From: chi@healthtech.com (Cambridge Healthtech Institute) Newsgroups: bionet.molbio.ageing Subject: ALZHEIMER’S DISEASE: ADVANCING THERAPEUTICS TOWARDS THE CLINIC Date: Mon, 24 Feb 1997 13:42:34 GMT Organization: Cambridge Healthtech Institute Lines: 91 Message-ID: <5es5nb$d35@xensei3.xensei.com> Reply-To: chi@healthtech.com NNTP-Posting-Host: chi.xensei.com X-Newsreader: Forte Free Agent 1.0.82 ALZHEIMER’S DISEASE: ADVANCING THERAPEUTICS TOWARDS THE CLINIC JUNE 16-17, 1997, L’ENFANT PLAZA WASHINGTON, DC PATHOGENESIS OF ALZHEIMER’S DISEASE Molecular Analysis of the Presenilin Genes: Dr. Rudolf Tanzi, Harvard Medical School (Confirmed) The Vasoactivity of b-Amyloid Peptides: Dr. Mike Mullan, University of South Florida (Confirmed) Epidemiological Differences, Racial Comparisons With Asians and Alzheimer’s Disease: Dr. Lon White, NIA-Asia-Pacific Office (Confirmed) The Link of ApoE4 with Acetylcholine Defects: Dr. Judes Poirier, McGill Centre for Studies in Aging (Invited) Presenlin Proteins in Alzheimer’s Disease: Dr. Martin Citron, Harvard Medical School (Confirmed) MEMORY ENHANCEMENT Calcium Hypothesis on Aging and Dementia, Dr. John F. Disterhoft, Northwestern University (Confirmed) Cholinergic Channel Modulator as a Novel Therapeutic Strategy for Alzheimer’s Disease: Dr. M.W. Holladay, Abbott Laboratories (to invite?) Aricept as a new Therapeutics for the Treatment of Alzheimer’s, Dr. Sharon L. Rogers, Eisai, Inc.(Invited) ABT 418 patch as a treatment for Alzheimer’s Disease: Dr. Paul Clark, Abbott Laboratories (Invited) Nicotine Receptor for Dementia: SIBIA (inquiry Sent) CX516 Memory Enhancer: Dr. Gary Lynch, UCI, Cortex Pharmaceuticals (Invited) Mutrifonet for Alzheimer’s Disease: Dr. Richard Finelli, Bayer (inquiry Sent) BETA-AMYLOID THERAPEUTICS Amyloidogenic Protein: Common Element Interaction as a target for Anti-Amyloid Therapy, Dr. Robert Kisilevsky, Neurochem, Inc., Queen’s University (Confirmed) Protease Inhibitors: Challenges to AD Drug Development, Dr. Kevin M. Felsenstein, Bristol-Myers Squibb Pharmaceutical Research Institute (Confirmed) Probing Molecular Mechanisms of Amyloid Fibril Formation: On the Pathway to Therapeutic Agents, Dr. Harry LeVine, III, Parke-Davis Pharmaceutical Research Division, Warner Lambert Company (Confirmed) Salen Manganese Complexes: Combine Superoxide Dusmutase/Catalase Mimics that are Protective in Models for Neurological Disorders, Dr. Susan R. Doctrow, Eukarion, Inc. (Confirmed) Therapeutics for Alzheimer’s Disease: Dr. Dale Schenk, Athena (Invited) Ab42-Therapeutic Target: Dr. Steven G. Younkin, Mayo Clinic-Jacksonville (Invited) Protease Inhibitor for Amyloidosis: Dr. Bob Siman, Cephalon, Inc. (Inquiry sent) NOVEL TARGETS FOR THERAPEUTIC INTERVENTION Therapeutics Targeting ApoE4, Glaxo Corporation (Invited) The use of Complement Inhibitors: Dr. Robert Frederickson, Gliatech Corporation ( inquiry sent) CRF Agonist as a Therapeutic, DHEA as a Neuroprotectant: Dr. P. Sunkara, Neurocrine ( inquiry sent) Therapeutics Targeting ApoE: Dr. Robert McBurney, Cambridge Neuroscience ( inquiry sent) Proteins that Interact with Beta-Amyloid Peptide and Presenilin I: Dr. Sudhir Sahasrabudhe, Hoechst Marion Roussel, Inc. (Confirmed) For registration and hotel information, please contact: Cambridge Healthtech Institute 1037 Chestnut Street Newton Upper Falls, MA 02164 USA Phone: 617-630-1300 Fax: 617-630-1325 e-mail: chi@healthtech.com http://www.healthtech.com/conferences/ ______________________________ Cambridge Healthtech Institute 1037 Chestnut Street Newton Upper Falls, MA 02164 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ tel: 617.630.1300 fax: 617.630.1325 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ inquiries@healthtech.com World Wide Web http://www.healthtech.com/conferences From owner-ageing@net.bio.net Sun Feb 23 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!newsfeed.internetmci.com!howland.erols.net!rill.news.pipex.net!pipex!uunet!in1.uu.net!152.163.170.17!newstf01.news.aol.com!audrey01.news.aol.com!not-for-mail From: janczek@aol.com (JanCzek) Newsgroups: bionet.molbio.ageing Subject: Measuring energy expenditure and bsal metabolism of gen obese mice Date: 24 Feb 1997 15:28:06 GMT Organization: AOL http://www.aol.com Lines: 18 Message-ID: <19970224152800.KAA26499@ladder02.news.aol.com> NNTP-Posting-Host: ladder02.news.aol.com X-Admin: news@aol.com Measuring basal metabolism of obese mice/rats We at Columbus Instruments developed very precise system ( open flow indirect calorimeter- "Oxymax") which measures VO2/VCO2 of genetically defective animals either is home cages or during exercise. We utilize differential measurement of % O2 and %CO2 between input and output of animal chambers with very high resolution gas analyzers (0.001%). Optional simultaneous measurements of animal activity and food intake is also possible. This system already helps researchers in major pharmaceutical companies from Amgen, through Merck to Sandoz and Zeneca. If you like to receive more information with detailed system description and application papers, let me know by providing street address to : Jan Czekajewski, Ph.D. Columbus Instruments Columbus, Ohio, USA janczek@aol.com ph(614)276-0861 From owner-ageing@net.bio.net Sun Feb 23 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!gatech!csulb.edu!hammer.uoregon.edu!arclight.uoregon.edu!newsfeeds.sol.net!news.maxwell.syr.edu!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!news.mindspring.com!usenet From: lockshin@mindspring.com (Richard A. Lockshin) Newsgroups: bionet.molbio.ageing Subject: NYC CELL DEATH CLUB MARCH MEETING Date: Mon, 24 Feb 1997 20:53:34 GMT Organization: MindSpring Enterprises, Inc. Lines: 46 Message-ID: <5esvd8$5kv@camel1.mindspring.com> Reply-To: lockshin@mindspring.com NNTP-Posting-Host: ip151.white-plains.ny.pub-ip.psi.net X-Server-Date: 24 Feb 1997 20:58:16 GMT X-Newsreader: Forte Free Agent 1.0.82 CELL DEATH SOCIETY (The Death Poets' Society) March meeting See below: WE ARE STILL CLEANING UP OUR EMAIL ADDRESS LIST. IF YOU SEE THIS NOTICE ON A NEWSNET AND WANT TO RECEIVE IT DIRECTLY, PLEASE SEND EMAIL INDICATION TO ME OR SUBSCRIBE AT HTTP://WWW.CELLDEATH-APOPOTOSIS.ORG IF YOU GET TWO NOTICES, PLEASE SEND US THE ADDRESSES AT WHICH YOU RECEIVE THEM AND INDICATE WHICH YOU PREFER. (MOLBIO.AGEING) ===================================================== EVERYONE, PLEASE, SO THAT WE CAN PROVIDE THE MOST EFFICIENT SERVICE PLEASE SEND COMPLETE MAILING ADDRESS, PHONE #, AND FAX #, AND INTEREST. ======================================================= Date: Wednesday, March 5, 1997 Time: 6:00-6:30 PM Pizza, 6:30-8:00 PM Talks & Discussion Place: Rockefeller Univ., 1230 York Ave. Weiss Research Bldg Room 301 Speakers: 1. Ron DePinho, Albert Einstein College of Medicine, "Cycling Towards Death" 2. Brian Wong, Rockefeller University, "Somatic cell genetics in the study of T-cell apoptosis". DRIVING AND ATTENDANCE INSTRUCTIONS Free parking after 5 PM at 66th St. & York Ave. Please car pool since parking space is limited. RSVP: To help us plan for the pizza and the number of attendees, we ask that you call Dr. Zakeri's lab (718-997-3429) and let them know of the number of people coming for the pizza, talk, & if you need parking. RSVP by Tuesday, March 4, 1997 Organizers: Zahra Zakeri, fax 718-997-3445, phone 718-997-3417 Raymond Birge fax 212-327-7943, phone 212-327-7412 SPONSORED BY: Oncor Appligene Cell Death and Differentiation Queens College & Graduate Center of C.U.N.Y. Rockefeller University Richard A. Lockshin (lockshin@mindspring.com;lockshin@sjumusic.stjohns.edu) check out Cell Death Soc web page: http://rdz.stjohns.edu/~lockshin/index.html From owner-ageing@net.bio.net Thu Feb 27 22:00:00 1997 Path: biosci!TENET.EDU!dashley From: dashley@TENET.EDU (Don Ashley) Newsgroups: bionet.molbio.ageing Subject: Govt mandated research? Date: 27 Feb 1997 23:00:44 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 9 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Has there ever been any federal or state legislation mandating research to find a way to stop the aging process (cure the aging disease)? Has there been any corporate grants for such research? (Besides Geron, of course). Would appreciate any references. Don From owner-ageing@net.bio.net Thu Feb 27 22:00:00 1997 Path: biosci!rutgers.rutgers.edu!uwm.edu!newsfeeds.sol.net!news.maxwell.syr.edu!newsfeed.nacamar.de!news.nacamar.de!news.nacamar.de!fu-berlin.de!news-ber1.dfn.de!news-lei1.dfn.de!news.uni-leipzig.de!news From: alz97@server3.medizin.uni-leipzig.de Newsgroups: bionet.molbio.ageing Subject: Alzheimer's disease - International Conference Date: Fri, 28 Feb 1997 11:11:05 +0100 Organization: PFI Lines: 102 Message-ID: <3316AF39.6BC3@server3.medizin.uni-leipzig.de> Reply-To: alz97@server3.medizin.uni-leipzig.de NNTP-Posting-Host: nc1.pfi.uni-leipzig.de Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 8bit X-Mailer: Mozilla 3.01Gold (Win95; I) International Conference Alzheimer’s Disease - From Basic Research to Clinical Applications Leipzig / Germany , June 4 - 7 1997 Neues Gewandhaus e-mail: alz97@server3.medizin.uni-leipzig.de http://www.uni-leipzig.de/medizin/alz97 Preliminary Program Wednesday, June 4 19.00 - 21.00 OPENING CEREMONY, HONORY LECTURE Sir Martin Roth, Cambridge Thursday, June 5 9.00 - 12.00 LONGITUDINAL STUDIES / PROGRESSION OF THE DIEASE L. Gustafson, Kopenhagen Clinical Manifestations and heterogeneity of AD K.Jobst, Oxford The course of AD B. Reisberg, New York Variability of progression in AD B. Winblad, Stockholm Mild cognitive decline - an early stage of AD? H.-J. Gertz, Leipzig Mild cognitve decline and its implications for therapeutic interventions I.G. McKeith, Newcastle What are the relations between Lewy body disease and AD? Ph. Scheltens, Amsterdam The influence of coincidental vascular pathology on symptomatology and course of AD 13.45 - 14.55 poster presentations / oral presentation of selected posters 15.00 - 18.00 Pathogenetic theories and therapeutic approaches (part I) free radicals: P. Riederer, Wuerzburg; M. Roesler, Wuerzburg calcium metabolism: W.E. Mueller, Mannheim; R. Ihl, Duesseldorf glucose metabolism: S. Hoyer, Heidelberg; S. Kanowski, Berlin 19.00 Concert, St Thomas` Church, afterwards Gala Dinner Auerbachs Keller Friday, June 6 8.30 - 12.00 SYMPOSIUM - SIGNIFICANCE OF TAU AND AMYLOID PATHOLOGY K. Jellinger, Vienna Introduction V.M.-Y. Lee, Pennsylvania Pathology of tau R. Nitsch, Hamburg APP and formation of ßA4 C.M. Wischik, Cambridge Therapeutic strategies deriving from tau-pathology Th. Arendt, Leipzig Alterations in signal transduction 11.00 - 12.00 Round table discussions: Consequences of tau and amyloid research for therapeutic strategies 13.45 - 14.55 oral presentation of selected posters 15.00 - 18.00 Pathogenetic theories and therapeutic approaches (part II) Immunpathology: P. Schubert, Muenchen; H.-J. Moeller, Muenchen cholinergic deficit: V. Bigl, Leipzig; A. Kurz, Muenchen glutamergic system: J. Kornhuber, Goettingen C.G. Gottfries, Goeteburg Saturday, June 7 9.00 - 12.00 SYMPOSIUM - RISK FACTORS AND PREVENTION Ch. Haas, Mannheim Genetics of AD J. Poirier, Montreal Apo E as a risk factor and predictor of therapeutic efficacy A.J. Holland, Cambridge Is Down‘s Syndrome a suitable modell of AD? H. Braak, Frankfurt/M Senile Dementia - an early onset disease? P. McGeer, Vancouver The role of antiininflammatory agents in the treatment of AD 12.00 - 13.00 Round table discussions: The problem of aetiological heterogeneity and its relevance for preventive and therapeutic strategies ORGANIZING SOCIETIES: University of Leipzig, Clinic of Psychiatry, Paul Flechsig Institute for Brain Research and Interdisciplinary Centre for Clinical Research Leipzig together with: Arbeitsgemeinschaft fuer Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) Deutsche Gesellschaft fuer Biologische Psychiatry (DGBP) Hirnliga e.V. Deutsche Alzheimer Gesellschaft e.V. Alzheimer Gesellschaft Leipzig e.V. Organizers: Hermann-Josef Gertz Thomas Arendt Secretariat: University of Leipzig, Clinic for Psychiatry Emilienstr. 14 04107 Leipzig / Germany phone: +49 341 9724500 fax +49 341 9724509 e-mail: alz97@server3.medizin.uni-leipzig.de www: http://www.uni-leipzig.de/medizin/alz.97