From owner-arrays@hgmp.mrc.ac.uk Mon Nov 5 15:41:39 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 0FCC517B19 for ; Mon, 5 Nov 2001 15:41:37 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 9E2B617A63 for ; Mon, 5 Nov 2001 15:41:35 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A766817BCD for ; Mon, 5 Nov 2001 15:41:30 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id PAA22707 for arrays-list@hgmp.mrc.ac.uk; Mon, 5 Nov 2001 15:38:59 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: evansj@ba.ars.usda.gov ("Jay Evans") X-Newsgroups: bionet.molbio.genearrays Subject: postdoc- Honey bee genomics/immunity/expression Date: 5 Nov 2001 15:38:58 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 50 Message-ID: Mime-Version: 1.0 Content-Type: text/plain; charset=US-ASCII Content-Transfer-Encoding: quoted-printable X-Complaints-To: news@net.bio.net Content-Disposition: inline X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 1116D17C29; Mon, 5 Nov 2001 15:38:53 +0000 (GMT) X-Received: from BA.ARS.USDA.GOV (unknown [199.133.48.254]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id ED1DF17A63; Mon, 5 Nov 2001 15:38:33 +0000 (GMT) X-Received: from BA-Message_Server by BA.ARS.USDA.GOV with Novell_GroupWise; Mon, 05 Nov 2001 10:43:45 -0500 X-Mailer: Novell GroupWise 5.5.4 X-To: >, > To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk We have funding for a post-doc interested in genomic approaches to study = disease resistance and larval development in honey bees. Goal is to = identify genes expressed by larval honey bees in response to bacterial = pathogens, using subtractive and/or normalized cDNA libraries, as well as = by screening with Drosophila orthologs. Candidate clones will be screened = for function and for variable expression across honey bee genotypes and = ages. Results will be integrated into an emerging functional-genomics = view of honey bee development. Project has laboratory, field, and = informatics/comparative evolution components. Sequencing, microarray and = computing facilities are available. Candidates must have a recent Ph.D. in Genetics or related field. = Knowledge of molecular-genetic techniques and computational and database = skills required. Knowledge of comparative genomics, social insect biology = and insect immunity are desirable. This is a 2-year, full-time position, = available immediately. There are some citizenship restrictions. Salary = is $44,352 - $69,099, commensurate with experience, plus benefits. =20 Please contact Dr. Jay Evans at 301-504-5143, fax 301-504-8736, e-mail: = evansj@ba.ars.usda.gov for information, and send applications (CV and list = of thre references) to Jay Evans by email or at: USDA-ARS, Bee Research = Laboratory, Bldg. 476, Beltsville, MD 20705. USDA is an equal opportunity= provider and employer. related papers: Evans, J. D., and Wheeler, D. E. (1999). "Differential gene expression = between developing queens and workers in the honey bee, Apis mellifera." = Proc. Nat. Acad. Sci. (USA), 96, 5575-5580. Evans, J. D., and Wheeler, D. E. (2000). "Expression profiles during the = honey bee caste program." Genome Biology, 2(1)1-6. Evans, J. D., and Wheeler, D. E. (2001). "Gene expression and the = evolution of insect polyphenisms." BioEssays, 23(1), 62-68. Evans, J. D. (in press) "Gene-expression approach to larval health and = development in honey bees", in Moritz, R.F.A., ed., Molecular mechanisms = of disease tolerance in honey bees, 5 pp. Jay D. Evans Bee Research Lab/USDA-ARS BARC-East Bldg. 476 Beltsville, MD 20705 USA 301-504-5143 FAX 301-504-8736 http://www.barc.usda.gov/psi/brl/beenome.html --- From owner-arrays@hgmp.mrc.ac.uk Wed Nov 7 05:41:46 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 581A517ADF for ; Wed, 7 Nov 2001 05:41:45 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 9E09817B22 for ; Wed, 7 Nov 2001 05:41:41 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 1495917ADF for ; Wed, 7 Nov 2001 05:41:35 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id FAA19097 for arrays-list@hgmp.mrc.ac.uk; Wed, 7 Nov 2001 05:28:31 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: newsletter@bio.com (Bio.com Newsletter) X-Newsgroups: bionet.molbio.genearrays Subject: Bio.com News & Updates Date: 7 Nov 2001 05:28:29 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 203 Message-ID: <02db01c16730$8665e380$3e82a5c7@bio.com> X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id C3A4B17ADF for ; Wed, 7 Nov 2001 05:28:26 +0000 (GMT) X-Received: from RELAY.bio.com (65-45-216-4.customer.algx.net [65.45.216.4]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 22ED317A61 for ; Wed, 7 Nov 2001 05:28:20 +0000 (GMT) X-Received: from fileserver01.bio.com ([199.165.130.202]) by RELAY.bio.com (Post.Office MTA v3.5.3 release 223 ID# 0-0U10L2S100V35) with ESMTP id com for ; Tue, 6 Nov 2001 21:25:40 -0800 X-Received: from biokatherine (bio-katherine.bio.com [199.165.130.62]) by fileserver01.bio.com (Post.Office MTA v3.5.3 release 223 ID# 0-68593U100L100S0V35) with SMTP id com for ; Tue, 6 Nov 2001 18:04:25 -0800 X-To: X-Priority: 3 (Normal) X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook CWS, Build 9.0.2416 (9.0.2911.0) X-Importance: Normal X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2600.0000 To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Bio.com News & Updates November 7, 2001 www.bio.com The Life Sciences Portal Jobs . News . Research . Reports . Software . Protocols . Tools =========================================================================== CONTENTS: =========================================================================== 1. Biotech News & Features: "Antitrust Lessons for Biotech" 2. InFocus Webcast: Audio file for "Angiogenesis" 3. Career Center: Set Up Your Free Profile Today 4. Jobs of the Week: "Research Associate" and others 5. Industry Reports and Software: "Molecules-3D Pro" 6. Laboratory Protocols: "DNA Microarray Hybridization" =========================================================================== 1. BIOTECH NEWS & FEATURES =========================================================================== -Featured Drug Target: Cyclooxygenase http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=1 What is the most commonly-taken drug today? It is an effective painkiller. It reduces fever and inflammation when the body gets overzealous in its defenses against infection and damage. It slows blood clotting, reducing the chance of stroke and heart attack in susceptible individuals. And, there is growing evidence that it is an effective addition to the fight against cancer. This wonder drug is aspirin. -Balancing Risks in the Licensing of Bioinformatics Tools http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=2 Bioinformatics is driven by the creation of IT tools that efficiently manipulate the vast amount of data generated by life science research. Bioinformatic research tools can be obtained through licensing agreements, in-house development, or acquisition of a bioinformatics venture. Of these choices, licensing agreements provide immediate access to current computational tools and provide the flexibility to switch to new products as the industry matures. -Antitrust Lessons for Biotech http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=3 It seems that every day the newspapers report Microsoft's ongoing battles. Bill Gates's defenders say "Let the software market perform it's own shakeout." Others say Bill Gates is trying to monopolize the software industry and that monopoly violates US antitrust laws. You might be thinking, "How can antitrust have anything to do with me? I'm not in the software business." Whether you are a senior executive in a company or a researcher with a clever idea to patent, you might want to spend some time thinking about antitrust laws. -Cyclin B1 is Tumor Antigen, Cancer Vaccine Candidate http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=4 Results from a study published in the November 2001 issue of the Journal of Experimental Medicine demonstrate that the protein cyclin B1 is a newly identified tumor antigen that holds promise as a candidate for the development of a cancer vaccine See: -Deep-Sea Sequencing http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=5 Scientists funded in part by the National Science Foundation (NSF) and affiliated from the University of Delaware and Amersham Biosciences, Inc., in Piscataway, New Jersey, have succeeded in conducting the first-ever DNA sequencing experiments at sea. Using the research vessel Atlantis and submersible Alvin, the team carried out a pioneering environmental genomic study of the strange life that inhabits super-hot hydrothermal vents almost two miles deep in the Pacific Ocean. -Water Shows Surprising Behavior at Molecular Level http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=6 The well understood peculiarities of water make life possible, but this most common fluid continues to surprise scientists. In an article published in the November 8 issue of the journal Nature, two University of Maine chemists and a scientist at the National Institutes of Health offer a new view of how water behaves at the scale of individual molecules, especially in tight spaces. For more Industry News, go to: http://www.bio.com/industryanalysis/industryanalysis_news.jhtml For more Research News, go to: http://www.bio.com/newsfeatures/newsfeatures_research.jhtml =========================================================================== 2. INFOCUS WEBCAST: =========================================================================== *To listen to the audio file from our last panel discussion, "Therapeutic Drug Targets: Angiogenesis," go to: http://chat.bio.com:8000/audio/angiogenesis_11012001.mp3 (use any mp3 player to listen to archived audio files) *To read the transcript of an interview with David Vaux, a pioneer in the field of apoptosis, go to: http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=7 *Our next InFocus feature, "Cell-Based Screening in Drug Discovery & Development," begins with a panel discussion on Thursday, November 15 at 10:00am Pacific Time. http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=8 =========================================================================== 3. CAREER CENTER =========================================================================== Bio.com offers the most comprehensive online Career Center in the life sciences industry. Set up your free personal profile today at: http://career.bio.com/pages/myresume.cfm?object=1&action=New Browse all job postings: http://career.bio.com/pages/featured.cfm?1 =========================================================================== 4. JOBS OF THE WEEK =========================================================================== Look at what's new on Bio.com Career Center this week: -Buck Institute for Age Research: Research Associate - Hook Lab http://career.bio.com/pages/jobsearch.cfm?object=5&job=774637&action=View -Agensys: Research Associate http://career.bio.com/pages/jobsearch.cfm?object=5&job=774478&action=View -Pharmaceutical Company: Senior Scientist Formulation Drug Development http://career.bio.com/pages/jobsearch.cfm?object=5&job=773808&action=View -Pharmaceutical Company: Director of Pharmacokinetics http://career.bio.com/pages/jobsearch.cfm?object=5&job=774493&action=View -Biopharmaceutical Company: BioAnalytical Method Development Senior Scientist http://career.bio.com/pages/jobsearch.cfm?object=5&job=774836&action=View Browse all jobs at http://career.bio.com/pages/featured.cfm =========================================================================== 5. INDUSTRY REPORTS & SOFTWARE =========================================================================== 1. Angiogenesis Inhibitors: A Detailed Analysis of Emerging Compounds http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=9 2. Drug Discovery Technology: A Combination of Opportunities http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=10 3. Molecules-3D Pro http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=11 For more reports available on Bio.com, visit: http://bio.com/store/store_publications.jhtml =========================================================================== 6. LABORATORY PROTOCOLS =========================================================================== Register here http://www.bioprotocol.com/register.jsp for access to the highest quality collection of laboratory protocols on the web, FREE! *Preview some of our latest additions: -Laser Capture Microdissection (LCM) http://www.bioprotocol.com/transfer.jsp?pgId=10001 -DNA Microarray Hybridization http://www.bioprotocol.com/transfer.jsp?pgId=10002 -High Efficiency Transformation of Yeast Cells http://www.bioprotocol.com/transfer.jsp?pgId=10003 =========================================================================== This message is sent to per your request To unsubscribe, simply hit "Reply" from this email account and put the word "unsubscribe" in the subject field. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Copyright © 1992-2001, Bio Online, Inc. All rights reserved. --- From owner-arrays@hgmp.mrc.ac.uk Thu Nov 8 15:12:31 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id C917617B05 for ; Thu, 8 Nov 2001 15:12:29 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A3C8A17BBB for ; Thu, 8 Nov 2001 15:11:58 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id B6FBA17BD1 for ; Thu, 8 Nov 2001 15:11:38 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id PAA04948 for arrays-list@hgmp.mrc.ac.uk; Thu, 8 Nov 2001 15:05:29 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: ASTONC@war.wyeth.com ("Christopher Aston") X-Newsgroups: bionet.molbio.genearrays Subject: Postdoctoral position available at Wyeth Ayerst-Research, Princeton, NJ. Date: 8 Nov 2001 15:05:28 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 34 Message-ID: Mime-Version: 1.0 Content-Type: text/plain; charset=US-ASCII Content-Transfer-Encoding: quoted-printable X-Complaints-To: news@net.bio.net Content-Disposition: inline X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 51DA117BBE for ; Thu, 8 Nov 2001 15:05:27 +0000 (GMT) X-Received: from bpftp4-rd.labs.wyeth.com (gw-rd1.wyeth.com [155.94.54.251]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 5CEA717B11 for ; Thu, 8 Nov 2001 15:05:23 +0000 (GMT) X-Received: from apps-qfe6.labs.wyeth.com (ra01m42.gv.us.pri [10.229.208.32]) by bpftp4-rd.labs.wyeth.com (Switch-2.1.0/Switch-2.1.0) with SMTP id fA8F5Mr10820 for ; Thu, 8 Nov 2001 10:05:22 -0500 (EST) X-Received: from ra01m42.gv.us.pri by apps-qfe6.labs.wyeth.com via smtpd (for bpftp4-rd.labs.wyeth.com [155.94.53.248]) with SMTP; 8 Nov 2001 15:05:22 UT X-Received: from USRA08-Message_Server by ra01m42.gv.us.pri with Novell_GroupWise; Thu, 08 Nov 2001 10:05:21 -0500 X-Mailer: Novell GroupWise Internet Agent 5.5.5.1 X-To: To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk A postdoctoral fellowship position focusing on technology development is = available within the neuroscience transcriptional profiling group at Wyeth = Ayerst Research. The role of the group is to use Affymetrix Genechips, = real time quantitative PCR (Taqman) and laser capture microdissection to = study gene expression patterns in model systems relevant to neuroscience = programs. The successful candidate will become proficient in using these = technologies and will develop related experimental approaches that can be = used by other members in the group. The work will focus specifically on issues related to transcription in the = CNS. The projects include (1) design and use of exon-specific microarrays = to investigate the role of alternate splicing in the CNS (2) development = of high-throughput quantitative PCR schemes (3) development of internal = standards and normalization schemes to reconcile microarray data with = quantitative PCR data and (4) in silico analysis of promoter sequences in = co-regulated genes identified by transcriptional profiling. The ideal candidate will have laboratory experience in using molecular = biology and genomic approaches. Experience with molecular biology software = such as GCG is required. Candidates must be uninhibited in exploring the = use of other bioinformatics tools. Familiarity using databases is a plus. = Since this position will address issues that are specific to transcription = in the CNS, a background in neuroscience is desirable. However, more = importantly, candidates must be able to think creatively about experimental= design and technology development. Ability to work interactively in a = multidisciplinary team environment is required. If interested, please send = your CV to: Christopher Aston, PhD, Wyeth-Ayerst Research, CN-8000, = Princeton, NJ, 08543-8000, astonc@war.wyeth.com. --- From owner-arrays@hgmp.mrc.ac.uk Wed Nov 14 01:57:10 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id BE8C017B3A for ; Wed, 14 Nov 2001 01:57:09 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 2145F17B03 for ; Wed, 14 Nov 2001 01:57:02 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A760217B2C for ; Wed, 14 Nov 2001 01:56:46 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id BAA20333 for arrays-list@hgmp.mrc.ac.uk; Wed, 14 Nov 2001 01:53:04 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: newsletter@bio.com ("Bio.com Newsletter") X-Newsgroups: bionet.molbio.genearrays Subject: Bio.com Webcast: Cell-Based Screening in Drug Discovery & Development Date: 14 Nov 2001 01:53:01 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 69 Message-ID: <03c401c16caf$2185ad90$3e82a5c7@bio.com> X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 9754217B3A for ; Wed, 14 Nov 2001 01:52:58 +0000 (GMT) X-Received: from RELAY.bio.com (65-45-216-4.customer.algx.net [65.45.216.4]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 22ED417B03 for ; Wed, 14 Nov 2001 01:52:54 +0000 (GMT) X-Received: from biokatherine ([199.165.130.62]) by RELAY.bio.com (Post.Office MTA v3.5.3 release 223 ID# 0-0U10L2S100V35) with SMTP id com for ; Tue, 13 Nov 2001 17:51:59 -0800 X-To: X-Priority: 3 (Normal) X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook CWS, Build 9.0.2416 (9.0.2911.0) X-Importance: Normal X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2600.0000 To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Join us this Thursday to hear leading scientists discuss the impact of cell-based screening in drug discovery and development. Bio.com's InFocus webcast, "Cell-Based Screening in Drug Discovery & Development," will be broadcast live on November 15 at 10:00am Pacific Time (1PM ET). To join us for this discussion, go to: http://www.bio.com/Redirectors/LinkRedirect11_6.jhtml?link=8 -Panelists: Paul Negulescu, Ph.D. Senior Vice President, Discovery Biology Aurora Biosciences Corporation Ole Thastrup, M.Sc. Pharm Chief Technology Officer BioImage A/S Fergus R. McKenzie, Ph.D. Section Manager, Cell Biology Cardiff Laboratories Amersham Biosciences -InFocus Sponsors: Amersham Biociences (http://amershambiosciences.com/na/) Cole Parmer (http://www.coleparmer.com/) ======================================================================= If you would like to submit questions to the panelists, please forward them to rfreder@bio.com ** For complete instructions on how to tune in to Bio.com's live webcast, go to: http://www.bio.com/InfocusRedirector.jhtml?link=1 ** To listen to the audio file from our recent webcast on Therapeutic Targets in Angiogenesis, go to: http://chat.bio.com:8000/audio/angiogenesis_11012001.mp3 (Use any mp3 player to listen to the archived audio files.) ======================================================================= This message is sent to per your request To unsubscribe, simply hit "Reply" from this email account and put the word "unsubscribe" in the subject field. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Copyright © 1992-2001, Bio Online, Inc. All rights reserved. --- From owner-arrays@hgmp.mrc.ac.uk Thu Nov 15 18:42:15 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id EE7ED17A82 for ; Thu, 15 Nov 2001 18:42:13 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 81CE617A6C for ; Thu, 15 Nov 2001 18:42:04 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 2A1C817A65 for ; Thu, 15 Nov 2001 18:41:50 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id SAA11248 for arrays-list@hgmp.mrc.ac.uk; Thu, 15 Nov 2001 18:28:59 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: news@inkonline.co.uk (Inkonline) X-Newsgroups: bionet.molbio.genearrays Subject: Good news Date: 15 Nov 2001 18:28:58 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 26 Message-ID: <1005848782.670@madasafish.com> Mime-Version: 1.0 Content-Type: text/plain; charset="US-ASCII"; format=flowed X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 8231C17A6C for ; Thu, 15 Nov 2001 18:28:56 +0000 (GMT) X-Received: from cmailg7.svr.pol.co.uk (cmailg7.svr.pol.co.uk [195.92.195.177]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 87B1E17A65 for ; Thu, 15 Nov 2001 18:28:38 +0000 (GMT) X-Received: from [195.92.67.23] (helo=mail18.svr.pol.co.uk) by cmailg7.svr.pol.co.uk with esmtp (Exim 3.13 #0) id 164RFb-0000p0-00 for arrays@net.bio.net; Thu, 15 Nov 2001 18:28:36 +0000 X-Received: from modem-166.south-dakota.dialup.pol.co.uk ([62.137.92.166] helo=mail.madasafish.com) by mail18.svr.pol.co.uk with smtp (Exim 3.13 #0) id 164RDM-0004lX-00 for arrays@net.bio.net; Thu, 15 Nov 2001 18:26:16 +0000 X-To: arrays@net.bio.net To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Hello Computer User, I appreciate that your time is very valuable, so I will be brief, to save money on your printer consumables, visit www.inkonline.co.uk Many thanks, Inkonline. A short message regarding our emails... Your email address has been passed to us as a user interested in purchasing computer supplies on-line. We appreciate that these lists are not always accurate. Please be aware that our service and our intentions are genuine and if this email is unwanted and causes offence, we apologise totally for the inconvenience. Unsubscribe from our lists by hitting the email link below and please be assured that your email address will not only be removed immediately from our lists but also be automatically filtered from possible inclusion in future lists provided to ourselves. mailto:notwanted@inkonline.co.uk Please note, www.inkonline.co.uk DO NOT PASS ANY INFORMATION ON TO ANY OTHER ORGANISATION! --- From owner-arrays@hgmp.mrc.ac.uk Fri Nov 16 19:27:07 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 513F117A85 for ; Fri, 16 Nov 2001 19:27:06 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A6FA717AFA for ; Fri, 16 Nov 2001 19:27:00 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 68A0317A69 for ; Fri, 16 Nov 2001 19:26:51 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id TAA14658 for arrays-list@hgmp.mrc.ac.uk; Fri, 16 Nov 2001 19:15:14 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: zorngibel@yahoo.de (zorngibel) X-Newsgroups: bionet.molbio.genearrays Subject: oligonucleotide design software Date: 16 Nov 2001 11:15:07 -0800 Organization: http://groups.google.com/ Lines: 14 Message-ID: <17289b19.0111161115.47910fdf@posting.google.com> Content-Type: text/plain; charset=ISO-8859-1 Content-Transfer-Encoding: 8bit X-Complaints-To: groups-abuse@google.com To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Dear newsgroup readers! I am thinking of making an oligonucleotide chip and I am looking for software which helps me in designing the oligos. My idea is that repetetive sequences should be eliminated, that stemloop, GC-content, length etc should be adjusted, and that specificity should be checked e.g. by blasting of the oligosequence against databases. I was searching the net a little bit for (ideally free) software that might serve my purpose - without much success. Maybe some of you can help me. Thanks in advance! W.Z. From owner-arrays@hgmp.mrc.ac.uk Mon Nov 19 19:57:05 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id B6B0D17AD2 for ; Mon, 19 Nov 2001 19:57:03 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id C560317AE1 for ; Mon, 19 Nov 2001 19:56:58 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id A028B17AD1 for ; Mon, 19 Nov 2001 19:56:56 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id TAA20639 for arrays-list@hgmp.mrc.ac.uk; Mon, 19 Nov 2001 19:52:33 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: apitlock@incellico.com ("Andy Pitlock") X-Newsgroups: bionet.molbio.genearrays Subject: Knowledge Mining for More Effective Research Date: 19 Nov 2001 19:52:32 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 29 Message-ID: Mime-Version: 1.0 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable X-Complaints-To: news@net.bio.net content-class: urn:content-classes:message X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id BDB3317AD1 for ; Mon, 19 Nov 2001 19:52:30 +0000 (GMT) X-Received: from net.incellico.com (net.incellico.com [168.215.112.174]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id ADBB317AAE for ; Mon, 19 Nov 2001 19:52:29 +0000 (GMT) X-Received: from exchange01.incellico.com (exchange1.office.arrayex.net [192.168.1.4]) by net.incellico.com (Postfix) with ESMTP id 1CC8322127 for ; Mon, 19 Nov 2001 14:39:39 -0500 (EST) X-MimeOLE: Produced By Microsoft Exchange V6.0.4712.0 X-MS-Has-Attach: X-MS-TNEF-Correlator: X-Thread-Topic: Knowledge Mining for More Effective Research X-Thread-Index: AcFxM6KkkLsevbuhQuaPFMdbIsdVrA== X-To: To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Dear Researchers: The Coded Electronic Life Library, or CELL, acts as a librarian of many public databases such as EMBL/GenBank, SWISSPROT, OMIM, Gene Ontologies and Medline by automatically cross-referencing their respective data in a searchable, ontology-based network. It also merges over 40 naming systems, ending the frustration that comes from many names being applied to the same biological entity. =20 The unique Entity Browser interface allows the user to graphically browse the ontological relationships. Using the CELL Entity Browser, you can visually navigate the ontological relationships between genes, proteins, organisms, biochemical pathways, disease models, tissue types and literature. Experimental results can rapidly be put into biological/functional context, extracting real knowledge from data. =20 Please take advantage of a free trial evaluation at http://www.incellico.com/cellsuite_entitybrowser2.html. For more information please contact me directly. Andrew Pitlock Client Relations Incellico, Inc. tel (919) 484-7222 ext 242 apitlock@incellico.com http://www.incellico.com --- From owner-arrays@hgmp.mrc.ac.uk Wed Nov 21 02:27:06 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id C851A17B23 for ; Wed, 21 Nov 2001 02:27:05 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 0A95717B45 for ; Wed, 21 Nov 2001 02:27:01 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 6F21417B40 for ; Wed, 21 Nov 2001 02:27:00 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id CAA04958 for arrays-list@hgmp.mrc.ac.uk; Wed, 21 Nov 2001 02:17:37 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: newsletter@bio.com ("Bio.com Newsletter") X-Newsgroups: bionet.molbio.genearrays Subject: Bio.com News and Updates Date: 21 Nov 2001 02:17:34 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 242 Message-ID: <034b01c17232$ca682a40$3e82a5c7@bio.com> X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 1B46C17B43 for ; Wed, 21 Nov 2001 02:17:33 +0000 (GMT) X-Received: from RELAY.bio.com (65-45-216-4.customer.algx.net [65.45.216.4]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id AF09617B23 for ; Wed, 21 Nov 2001 02:17:30 +0000 (GMT) X-Received: from biokatherine ([199.165.130.62]) by RELAY.bio.com (Post.Office MTA v3.5.3 release 223 ID# 0-0U10L2S100V35) with SMTP id com for ; Tue, 20 Nov 2001 18:16:47 -0800 X-To: X-Priority: 3 (Normal) X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook CWS, Build 9.0.2416 (9.0.2911.0) X-Importance: Normal X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2600.0000 To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Bio.com News & Updates November 21, 2001 www.bio.com The Life Sciences Portal Jobs . News . Research . Reports . Software . Protocols . Tools =========================================================================== CONTENTS: =========================================================================== 1. Biotech News & Features: "A New Clue to How Viruses Infect Cells" 2. InFocus Webcast: "Cell-Based Screening in Drug Discovery" 3. Career Center: Set Up Your Free Profile Today 4. Jobs of the Week: "Laboratory Project Coordinator" and others 5. Featured Employer: eXegenics 6. Industry Reports and Software: "LABTrack" 7. Laboratory Protocols: "In-Gel Kinase Assay" 8. Product Highlight: MegaBACE 4000 DNA Analysis System =========================================================================== 1. BIOTECH NEWS & FEATURES =========================================================================== -Developing Methods of Genetic Analysis to Improve Cancer Risk Assessment http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=1 Using genotypic selection, the oncogene and tumor suppressor gene Mutations that are the earliest persistent changes in tumor development can be measured and used as biomarkers for cancer risk. Three different genotypic selection methods have been developed. -DNA Methylation Potential New Prostrate Cancer Diagnostic http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=2 Scientists at Johns Hopkins have found that measuring the level of a DNA methylation could greatly strengthen standard detection of curable, early-stage prostate cancer. The report is published in the November 21, 2001 issue of the Journal of the National Cancer Institute. -Space-Travel Stress Reactivates EBV Virus http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=3 Every time astronauts blast off for outer space, they carry tiny stowaways with them-viruses that have been latent in their bodies since childhood. These viruses, typically including Epstein-Barr, herpes simplex and varicella zoster (which causes chicken pox in children) exist in almost everyone, but they have a special significance for astronauts, whose immune systems are weakened by the unique stresses of spaceflight. -Attractive, Defensive Roles for Flower Pigments http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=4 When some insects zero in on a flower for nectar, their ultraviolet vision is guided by a bull's-eye "painted" on the plant by chemical compounds. Now, chemical ecologists at Cornell University have discovered a second job for these compounds: warding off herbivores. -A New Clue to How Viruses Infect Cells http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=5 In a development that holds ramifications for gene therapy and infection-fighting drugs, a research collaboration led by Carlos Bustamante of Berkeley Lab's Physical Biosciences Division has discovered the mechanism by which at least some viruses infect the cells of other organisms with their DNA. The mechanism involves one of the most powerful biomolecular motors ever observed. For more Industry News, go to: http://www.bio.com/industryanalysis/industryanalysis_news.jhtml For more Research News, go to: http://www.bio.com/newsfeatures/newsfeatures_research.jhtml =========================================================================== 2. INFOCUS WEBCAST: =========================================================================== *Click here for a Free T-shirt and a chance to win COBRA 2-way radios (set of 2) with charger from Amersham Biosciences: http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=10 *To listen to the audio file from our last panel discussion, "Cell-Based Screening in Drug Discovery & Development," go to: http://chat.bio.com:8000/audio/cellscreen_11152001.mp3 (use any mp3 player to listen to archived audio files) *To read the transcript of the discussion, go to: http://www.bio.com/newsfeatures/newsfeatures_infocus.jhtml?action=transcript (Be sure to copy the entire URL and paste it into your browswer) *Both the transcript and audio file from our panel discussion on "Chemical Genomics" are now available. -To read the transcript, go to: http://www.bio.com/file_temp/chemgenomics.pdf -To listen to the audio file, go to: http://chat.bio.com:8000/audio/ChemGene_10042001.mp3 *Our next InFocus feature, "DNA Microarrays: Platforms and Applications," begins with a panel discussion on Thursday, December 6 at 1:00pm Pacific Time. http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=6 *Archive of past InFocus events: http://www.bio.com/newsfeatures/newsfeatures_fochives.jhtml =========================================================================== 3. CAREER CENTER =========================================================================== Bio.com offers the most comprehensive online Career Center in the life sciences industry. Set up your free personal profile today at: http://career.bio.com/pages/myresume.cfm?object=1&action=New Browse all job postings: http://career.bio.com/pages/featured.cfm?1 =========================================================================== 4. JOBS OF THE WEEK =========================================================================== Look at what's new on Bio.com Career Center this week: -eXegenics: Scientist-Informatics and Screening http://career.bio.com/pages/jobsearch.cfm?object=5&job=774867&action=View -Genomics-Based Biopharmaceutical Company: Director of Pharmacogenomics http://career.bio.com/pages/jobsearch.cfm?object=5&job=775236&action=View -West Pharmaceuticals Company: Laboratory Project Coordinator http://career.bio.com/pages/jobsearch.cfm?object=5&job=775060&action=View -Sunesis Pharmaceuticals: Research Associate-Medicinal and Synthetic Organic Chemistry http://career.bio.com/pages/jobsearch.cfm?object=5&job=775251&action=View -Biotechnology Company, California: Director of Fermentation and Process Development http://career.bio.com/pages/jobsearch.cfm?object=5&job=775369&action=View -Biotechnology Company, California: Senior Scientist, Toxicologist http://career.bio.com/pages/jobsearch.cfm?object=5&job=775237&action=View Browse all jobs at http://career.bio.com/pages/featured.cfm =========================================================================== 5. FEATURED EMPLOYER =========================================================================== eXegenics Inc. is a biotechnology company that has developed a suite of platform technologies - QCT (Quantum Core Technology) and OASIS (Optimized Anti-Sense Inhibitory Sequence) to accelerate and enhance the discovery and creation of novel pharmaceutical products. The company is also engaged in a collaborative program with Bristol Myers Squibb to optimize the production of paclitaxel, the active ingredient in Taxol. http://career.bio.com/pages/job_get.cfm?EmployerID=1619 =========================================================================== 6. INDUSTRY REPORTS & SOFTWARE =========================================================================== 1. Target Identification and Validation http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=7 2. Drug Discovery Industry Review http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=8 3. LABTrack http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=9 For more reports available on Bio.com, visit: http://bio.com/store/store_publications.jhtml =========================================================================== 7. LABORATORY PROTOCOLS =========================================================================== Register here http://www.bioprotocol.com/register.jsp for access to the highest quality collection of laboratory protocols on the web, FREE! *Preview some of our latest additions: -Infection of Cells with Retroviruses http://www.bioprotocol.com/transfer.jsp?pgId=11000 -Apoptosis Assay using DNA Laddering http://www.bioprotocol.com/transfer.jsp?pgId=11001 -In-Gel Kinase Assay http://www.bioprotocol.com/transfer.jsp?pgId=11002 =========================================================================== 8. PRODUCT HIGHLIGHT =========================================================================== MegaBACE 4000 DNA Analysis System from Amersham Biosciences 384 capillaries: Four times the throughput Lowest sequencing cost per base More genomes per week Better efficiencies: less labor and less space For more info on MegaBACE visit http://www.amershambiosciences.com/application/MegaBACE/ =========================================================================== This message is sent to per your request To unsubscribe, simply hit "Reply" from this email account and put the word "unsubscribe" in the subject field. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Copyright © 1992-2001, Bio Online, Inc. All rights reserved. --- From owner-arrays@hgmp.mrc.ac.uk Wed Nov 28 17:42:25 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id DB64817B6C for ; Wed, 28 Nov 2001 17:42:23 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 8003F17B76 for ; Wed, 28 Nov 2001 17:42:18 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 074F817B6C for ; Wed, 28 Nov 2001 17:42:13 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id RAA03821 for arrays-list@hgmp.mrc.ac.uk; Wed, 28 Nov 2001 17:35:27 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: apitlock@incellico.com ("Andy Pitlock") X-Newsgroups: bionet.molbio.genearrays Subject: Free Trial: Knowledge Mining - Biological Context Date: 28 Nov 2001 17:35:25 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 29 Message-ID: Mime-Version: 1.0 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable X-Complaints-To: news@net.bio.net content-class: urn:content-classes:message X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id E09C117B64 for ; Wed, 28 Nov 2001 17:35:16 +0000 (GMT) X-Received: from net.incellico.com (unknown [168.215.112.169]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 7B5DF17A7E for ; Wed, 28 Nov 2001 17:35:10 +0000 (GMT) X-Received: from exchange01.incellico.com (exchange1 [192.168.1.4]) by net.incellico.com (Postfix) with ESMTP id E966324B for ; Wed, 28 Nov 2001 12:28:12 -0500 (EST) X-MimeOLE: Produced By Microsoft Exchange V6.0.4712.0 X-MS-Has-Attach: X-MS-TNEF-Correlator: X-Thread-Topic: Free Trial: Knowledge Mining - Biological Context X-Thread-Index: AcF4MvfX8y/prOz7QBqTNzqLJwOznw== X-To: To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Dear Researchers: The Coded Electronic Life Library, or CELL, acts as a librarian of many public databases such as EMBL/GenBank, SWISSPROT, OMIM, Gene Ontologies and Medline by automatically cross-referencing their respective data in a searchable, ontology-based network. It also merges over 40 naming systems, ending the frustration that comes from many names being applied to the same biological entity. =20 The unique Entity Browser interface allows the user to graphically browse the ontological relationships. Using the CELL Entity Browser, you can visually navigate the ontological relationships between genes, proteins, organisms, biochemical pathways, disease models, tissue types and literature. Experimental results can rapidly be put into biological/functional context, extracting real knowledge from data. =20 Please take advantage of a free trial evaluation at http://www.incellico.com/cellsuite_entitybrowser2.html. For more information please contact me directly. Andrew Pitlock Account Executive - Client Relations Incellico, Inc. tel (919) 484-7222 ext 242 http://www.incellico.com --- From owner-arrays@hgmp.mrc.ac.uk Thu Nov 29 04:12:22 2001 Return-Path: Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 3757617B63 for ; Thu, 29 Nov 2001 04:12:21 +0000 (GMT) Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id DE14117B79 for ; Thu, 29 Nov 2001 04:12:16 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 182D217A4E for ; Thu, 29 Nov 2001 04:12:15 +0000 (GMT) Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id EAA20937 for arrays-list@hgmp.mrc.ac.uk; Thu, 29 Nov 2001 04:03:26 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: newsletter@bio.com ("Bio.com Newsletter") X-Newsgroups: bionet.molbio.genearrays Subject: Bio.com News & Updates Date: 29 Nov 2001 04:03:24 -0000 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Lines: 246 Message-ID: <03cc01c1788a$ec3ac8e0$3e82a5c7@bio.com> X-Complaints-To: news@net.bio.net X-Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 5C28B17B88 for ; Thu, 29 Nov 2001 04:03:22 +0000 (GMT) X-Received: from RELAY.bio.com (65-45-216-4.customer.algx.net [65.45.216.4]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 1E6DE17B86 for ; Thu, 29 Nov 2001 04:03:20 +0000 (GMT) X-Received: from biokatherine ([199.165.130.62]) by RELAY.bio.com (Post.Office MTA v3.5.3 release 223 ID# 0-0U10L2S100V35) with SMTP id com for ; Wed, 28 Nov 2001 20:02:30 -0800 X-To: X-Priority: 3 (Normal) X-MSMail-Priority: Normal X-Mailer: Microsoft Outlook CWS, Build 9.0.2416 (9.0.2911.0) X-Importance: Normal X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2600.0000 To: arrays@net.bio.net Sender: owner-arrays@hgmp.mrc.ac.uk Precedence: bulk Bio.com News & Updates November 29, 2001 www.bio.com The Life Sciences Portal Jobs . News . Research . Reports . Software . Protocols . Tools =========================================================================== CONTENTS: =========================================================================== 1. Biotech News & Features: "Gravity Affects Sperm Behavior" 2. InFocus Webcast: Cell-Based Screening in Drug Discovery 3. Career Center: Set Up Your Free Profile Today 4. Jobs of the Week: "Staff Scientist" 5. Featured Employer: Roche Molecular Systems 6. Industry Reports and Software: Drug Discovery Industry Review 7. Investment Research: Free Investment Research from SCO Group 8. Product Highlight: MegaBACE 4000 DNA Analysis System =========================================================================== 1. BIOTECH NEWS & FEATURES =========================================================================== Gravity Affects Sperm Behaviour http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=1 According to Joseph Tash, a NASA-supported physiologist at the University Of Kansas Medical Center, sperm behave differently in the near-weightless environment of space than they do on Earth. Whether these changes will impair or aid fertility, he doesn't yet know. But, says Tash, it's becoming increasingly clear that in outer space, fertilization-of humans, of animals, and even of plants-will very likely be affected. Native Corn Found to be Contaminated with Foreign Genes http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=2 Some of Mexico's native varieties of corn grown in remote regions have Been contaminated by transgenic DNA, a finding that has both surprised and dismayed the University of California, Berkeley, researchers who made the discovery. Bioinformatics Tool Predicts Higher Human Gene Number http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=3 In order to study genes for a wide variety of research, diagnostic, or therapeutic purposes, scientists use computer programs that analyze DNA sequences. These programs indicate where pieces of genes are located within what is frequently a vast and complex genetic landscape. Although conventional programs detect many parts of genes with ease, they fail when it comes to detecting two important elements-first exons and promoters. Hubble Detects Atmosphere on Distant Star http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=4 Astronomers using NASA's Hubble Space Telescope have made the first direct detection and chemical analysis of the atmosphere of a planet outside our solar system. Their unique observations demonstrate it is possible with Hubble and other telescopes to measure the chemical makeup of extrasolar planets' atmospheres and potentially to search for chemical markers of life beyond Earth. A Genomic-Systems Biology Map for Cardiovascular Function http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=5 By combining gene traits with biological functions, Medical College of Wisconsin researchers have made the first global assessment of cardiovascular function in rats. Their paper is published in the current issue of Science. For more Industry News, go to: http://www.bio.com/industryanalysis/industryanalysis_news.jhtml For more Research News, go to: http://www.bio.com/newsfeatures/newsfeatures_research.jhtml =========================================================================== 2. INFOCUS WEBCAST: =========================================================================== Bio.com's InFocus series examines the cutting-edge technologies that are driving advances in the biomolecular sciences. InFocus content comprises the latest methods and research trends in academia and industry and features exclusive interviews and live, streaming audio webcasts with leaders in the field. *To listen to the audio file of our last panel webcast, "Cell-Based Screening in Drug Discovery & Development," go to: http://chat.bio.com:8000/audio/cellscreen_11152001.mp3 (use any mp3 player to listen to archived audio files) *To read the transcript of the webcast, go to: http://www.bio.com/file_temp/cellscreen.pdf *Our next InFocus feature, "DNA Microarrays: Platforms and Applications," begins with a panel webcast on Thursday, December 6 at 1:00pm Pacific Time. For details, go to: http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=6 *In the month of December we will host a special webcast on 'real world' applications of PCR, including biodefense applications. Date and time TBA. =========================================================================== 3. CAREER CENTER =========================================================================== Bio.com offers the most comprehensive online Career Center in the life sciences industry. Set up your free personal profile today at: http://career.bio.com/pages/myresume.cfm?object=1&action=New Browse all job postings: http://career.bio.com/pages/featured.cfm?1 =========================================================================== 4. JOBS OF THE WEEK =========================================================================== Look at what's new on Bio.com Career Center this week: 1. Celera Diagnostics: Staff Scientist http://career.bio.com/pages/jobsearch.cfm?object=5&job=775570&action=View 2. Itrac, LLC: Scientist Level I/II - Formulation http://career.bio.com/pages/jobsearch.cfm?object=5&job=775259&action=View 3. Biotechnology Company, Missouri: Business Applications Specialist http://career.bio.com/pages/jobsearch.cfm?object=5&job=775376&action=View 4. European Biopharmaceutical Company, California: Sr. Research Associate- Upstream Process Development http://career.bio.com/pages/jobsearch.cfm?object=5&job=775269&action=View 5. Therapeutic Biotechnology Company, California: Sr. Molecular Immunologist http://career.bio.com/pages/jobsearch.cfm?object=5&job=775167&action=View Browse all jobs at http://career.bio.com/pages/featured.cfm =========================================================================== 5. FEATURED EMPLOYER =========================================================================== At Roche Diagnostics, we use our Nobel prize-winning PCR technology to push the limits of diagnostics for genetic and viral discoveries. We currently are seeking capable and experienced individuals for our Alameda and Pleasanton (Northern California) campuses. We offer an excellent compensation and benefits program, including matching 401(k), a pension plan, 100% tuition reimbursement, health club discounts and childcare assistance. http://www.roche.com/diagnostics/content/molsys/f_4.html =========================================================================== 6. INDUSTRY REPORTS & SOFTWARE =========================================================================== 1. Target Identification and Validation http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=7 2. Drug Discovery Industry Review http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=8 3. LABTrack Software http://www.bio.com/Redirectors/LinkRedirect11_20.jhtml?link=9 For more reports available on Bio.com, visit: http://bio.com/store/store_publications.jhtml =========================================================================== 7. INVESTMENT RESEARCH =========================================================================== SCO Financial Group, a registered investment advisor focused on identifying emerging growth companies in the healthcare sectors, has made its investment research available, for free, to online investors at Bio.com. 1. Cytogen Corporation http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=7 2. Nastech Pharmaceutical Company, Inc. http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=8 3. Big Pharma's Pipelines Running Low-Eyes Turn to Biotech http://www.bio.com/Redirectors/LinkRedirect11_28.jhtml?link=9 For more investment research, go to: http://www.bio.com/industryanalysis/industryanalysis_financial.jhtml =========================================================================== 8. PRODUCT HIGHLIGHT =========================================================================== MegaBACE 4000 DNA Analysis System from Amersham Biosciences 384 capillaries: Four times the throughput Lowest sequencing cost per base More genomes per week Better efficiencies: less labor and less space For more info on MegaBACE visit http://www.amershambiosciences.com/application/MegaBACE/ =========================================================================== Sponsored by: BioITWorld Conference & Expo When: March 12-14, 2002 Where: World Trade Center Boston, Boston, Massachusetts BioITWorld is the most comprehensive life sciences event focused Exclusively on the integration and utilization of information Technologies and bioinformatics across the entire life sciences discovery and development processes. Pre-Register using Priority Code: BC01 for significant savings off all conference programs at http://www.bioitworld.com =========================================================================== This message is sent to per your request To unsubscribe, simply hit "Reply" from this email account and put the word "unsubscribe" in the subject field. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Copyright © 1992-2001, Bio Online, Inc. All rights reserved. ---