From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!NIGHTSHADE.CIT.CORNELL.EDU!epaul
From: epaul@NIGHTSHADE.CIT.CORNELL.EDU ("Edie Paul")
Newsgroups: bionet.software
Subject: NCBI Vibrant Toolkit
Date: 1 Dec 1994 11:05:59 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 10
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <9412011859.AA09572@nightshade.cit.cornell.edu>

I will soon be undertaking the development of a graphical user interface
that I would like to run on multiple platforms, particularly UNIX and MS
Windows.  I am considering the Vibrant toolkit for this, but I'd be
interested in hearing any pros/cons/comments anyone has, as well as suggestions
for other public domain (or fairly inexpensive) software to do the same kind
of thing.  Linux for the PCs is not an option.

Thanks,
Edie Paul
epaul@nightshade.cit.cornell.edu

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!uhog.mit.edu!europa.eng.gtefsd.com!library.ucla.edu!news.mic.ucla.edu!steve3.mbi.ucla.edu!visick
From: Jon Visick <visick@ewald.mbi.ucla.edu>
Newsgroups: bionet.software
Subject: Re: Bibliography package
Date: 2 Dec 1994 00:56:52 GMT
Organization: UCLA
Lines: 5
Distribution: world
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References: <dpogue.32.0017D550@obsnsrv1.bio.uoknor.edu>
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X-XXDate: Fri, 2 Dec 94 04:57:50 GMT

 Darrell Pogue, dpogue@obsnsrv1.bio.uoknor.edu writes:
>I am looking for a bibliography package for windows.  Any suggestions?

EndNote is the best, hands down.  It's not "for" Windoze, but
it will run under Windoze, if you must.

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!HEMEROTECA.ICFES.GOV.CO!internet
From: internet@HEMEROTECA.ICFES.GOV.CO (Usuarios de Internet)
Newsgroups: bionet.software
Subject: Oferring a new Institute of Eco-Genetics in Amazonian Biodiversity
Date: 2 Dec 1994 08:41:06 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 40
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Message-ID: <Pine.3.89.9412021157.G23804-0100000@hemeroteca.icfes.gov.co>
NNTP-Posting-Host: net.bio.net

Dear Sir or Lady:

This is a NEWS-Letter to inform you of the existance
of a brand new INSTITUTE OF ECOLOGICAL-GENETICS TO STUDY THE AMAZONIAN=20
BIODIVERSITY . For further information write=20
to: Dr. Hugo Hoenigsberg                             =09
    Instituto de Genetica-Ecologica y Biodiversidad Amazonica
    Cra.4 No.71-69
    Bogota D.C.COLOMBIA.
    FAX: 612 7369
You can sent your C.V.to our personal address above. We are considering=20
applications to fill posts as research scientific staff members.=20
Evolutionary-Biologists, geneticists,ecologists, systematist,=20
botanists,zoologists, mathematicians and other Ph.D. individuals=20
interested in neo-tropical biological research with at least 10 years of=20
research experience preferably, but not exclusively, in the trop=A1cs, and=
=20
about 10 published scientific papers will be considered. This new=20
Institute will study Amazonian biodiversity. Although its main purpose is=
=20
research it will by inclination help, not only to preserve the Amazonian=20
biodiversity , but also to diseminate the gospel of international=20
management of the most wonderful world natural reserve for which it is=20
worth to dedicate ones life. There will also be graduate degrees to be=20
dealt with. For academic life within the Institute, please contact=20
the Rector of the Amazonian University as follows:  =20
                Dr. Ernesto Fajardo
                Universidad de la Amazonia
                Florencia, Caqueta
                Colombia.
                FAX: (988 35) 8231
Florencia is the capital of the State of Caqueta, and Caqueta is one of=20
the three Amazonian States of Colombia. We will be working closely with=20
Peruvian and Brazilian scientist interested in Amazonian biodiversity.=20
Our Central offices and research labs will be in Florencia's souroundings. =
=20
Hoping to see you soon=20
                 Yours truly, =20
                =20
                 Hugo Hoenigsberg

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!Germany.EU.net!EU.net!julienas!genethon!manu
From: manu@genethon.fr (Emmanuel Barillot)
Subject: clone ordering software
Message-ID: <1994Dec2.182655@genethon.fr>
Originator: manu@genethon.genethon.fr
Sender: news@genethon.fr
Nntp-Posting-Host: genethon.genethon.fr
Organization: Genethon -- Human Genome Research Centre
Date: Fri, 2 Dec 1994 17:26:55 GMT
Lines: 5


I am looking for a software ordering cosmids from their Restriction Fragment
fingerprints. I would like to try several programs, interactive or fully
automatic. If you know about such programs or if you have experience
in this area, please let me know.

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!swrinde!pipex!bnr.co.uk!bmdhh222.bnr.ca!bcarh8ac.bnr.ca!bcarh189.bnr.ca!nott!nrcnet0.nrc.ca!ratilal
From: "reithm@imb.lan.nrc.ca" <Michael E. Reith>
Newsgroups: bionet.software
Subject: Re: BLAST or BLAST-like software for Windows
Date: 2 Dec 1994 13:34:45 GMT
Organization: National Research Council, Canada
Lines: 45
Message-ID: <3bn7pl$55m@nrcnet0.nrc.ca>
References: <3blef9$p1j@news.CCIT.Arizona.EDU>
NNTP-Posting-Host: reith.imb.nrc.ca

valeryt@ag.arizona.edu (Valery Thompson) wrote:
>
> I am looking for some software to perform BLAST searches that I can run 
> directly from my PC.  I have tried the network version available from NCBI and 
> find it very cumbersome to use particularly since it is a DOS only program
> and I have to not only exit Windows, but also unload my Windows network
> driver in order to use it.  I have a demo copy of WinGenie which has 
> several nice programs for sequence searching and sequence alignment,
> but requires me to send the requests by email.
> 
> Is there anything available that combines the abilities of these two programs?
> Any input would be appreciated.
> 
> Valery Thompson
> Muscle Biology Group
> University of Arizona

The WWW/Mosaic search by way of NCBI is a good one, although I find it
cumbersome to save the results of these searches.  Another alternative
is to multiplex your packet driver so as to be able to run Windows and 
DOS software simultaneously.  Pktmux (at boombox.micro.umn.edu in 
/pub/pc/packet-drivers/drivers) does this nicely.  The relevant lines 
of my autoexec.bat are:

ODIPKT 1 99
pktmux 
pktdrv 60
pktdrv 61
WINPKT 0X61

ODIPKT loads the packet driver at interrupt 0x63, pktmux multiplexes
it twice (the default) at 0x60 and 0x61 - pktdrv statements.  Winpkt
is then loaded at 0x61 so that BLAST can use the packet driver at 
0x60, which it requires.  In Windows, make sure to set TCPMAN 
(assuming you're using Trumpet winsock) to use the packet driver at 
0x61.  You can then open a DOS window within Windows and run the BLAST 
software in it.  I've set up a batch file to run multiple searches one 
after the other, using the same set of parameters.  I find this the
most convenient way to do lots of searches at one time.  

Mike Reith
Marine Biology
NRC Institute for Marine Biosciences
reithm@imb.lan.nrc.ca
 

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!uhog.mit.edu!europa.eng.gtefsd.com!howland.reston.ans.net!pipex!uknet!daresbury!not-for-mail
From: nce@rri.sari.ac.uk (Nigel Eastmond)
Newsgroups: bionet.software
Subject: GeneRunner Question
Date: 2 Dec 1994 15:46:55 -0000
Organization: Rowett Research Institute
Lines: 13
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <3bnfhf$h3i@mserv1.dl.ac.uk>
Apparently-To: <bio-soft@dl.ac.uk>

I recently came across a GeneRunner for Windows output for a probe I am
interested in.  The printout shows the possible dimers, bulge loops etc.
linked to the oligo by | signs and + signs.  What difference does the
use of the two bonding signs signify?

o------------------------------oOo------------------------------o
| Nigel C. Eastmond             |   Email nce@rri.sari.ac.uk    |
| Rowett Research Institute     |   Tel   +44 244 712751        |
| Aberdeen                      |   Fax   +44 244 715349        |
| Scotland                      |                               |
o------------------------------oOo------------------------------o



From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!rutgers!gatech!howland.reston.ans.net!pipex!lyra.csx.cam.ac.uk!mole.bio.cam.ac.uk!tjrc1
From: tjrc1@mole.bio.cam.ac.uk (Tim Cutts)
Newsgroups: bionet.software
Subject: Re: Bibliography package
Date: 2 Dec 1994 08:57:25 GMT
Organization: University of Cambridge, England
Lines: 14
Message-ID: <3bmnhl$alb@lyra.csx.cam.ac.uk>
References: <dpogue.32.0017D550@obsnsrv1.bio.uoknor.edu> <3blrck$idt@news.mic.ucla.edu>
NNTP-Posting-Host: mole.bio.cam.ac.uk

Jon Visick <visick@ewald.mbi.ucla.edu> writes:

> Darrell Pogue, dpogue@obsnsrv1.bio.uoknor.edu writes:
>>I am looking for a bibliography package for windows.  Any suggestions?

>EndNote is the best, hands down.  It's not "for" Windoze, but
>it will run under Windoze, if you must.

A combination of Refs and WinRefer will do everything EndNote for the
Macintosh can do (including DDE to your word-processor), and will only
cost you 30 pounds, and no upgrade charges either.  Plus they're both
Windows programs.

Tim.

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!CS.Arizona.EDU!news.Arizona.EDU!hamblin.math.byu.edu!sol.ctr.columbia.edu!spool.mu.edu!bloom-beacon.mit.edu!gatech!swrinde!pipex!uunet!newsflash.concordia.ca!nstn.ns.ca!ac.dal.ca!ac.dal.ca!nntp
Newsgroups: bionet.software
Subject: Re: Grateful Med under OS/2
Message-ID: <1994Dec1.232317.30843@ac.dal.ca>
From: JWChish@AC.DAL.CA (Jeffrey Chisholm)
Date: 1 Dec 94 23:23:17 -0400
References: <94332.153831RROXBY@MAINE.MAINE.EDU>
Organization: Dalhousie University
Nntp-Posting-Host: jchisholm.med.dal.ca
X-Newsreader: WinVN 0.92.6+
Lines: 30

In article <94332.153831RROXBY@MAINE.MAINE.EDU>, Robert Roxby <RROXBY@MAINE.MAINE.EDU> says:
>
>Is anybody running Grateful Med under OS/2?  I just received the package
>and have not received a logon id yet, but the installation seems
>rather definate about having NCSA somethin-or-other telnet.
>I have the telnet that comes with IBM TCP/IP for OS/2 v 2.0.
>If experience is any guide, this will be a problem.  Like
>to have any experiences or advice, though.  Thanks,
>Bob

Any telnet should do, although many don't support color ansi.

I'm not all that familiar with OS/2, but if it will run winsock
compliant aplications, the telnet client from Dart Communications is
the best I've seen.  I think it is either shareware or freeware and
available on many ftp sites. Alternatively you can email me for access
to it on my ftp site. The file is called vt220.exe.  The program, has
very nice easy on the eyes text and supports color ansi, keymapping
and a range of other useful features.  Also, the program seems much
more stable than other telnet clients I have run under windows.

BTW, I have a very fast link!!

Jeffrey Chisholm
Lipoprotein Research Group
Dept. of Biochemistry
Dalhousie Universiy
Halifax, N.S., Can.

JWCHISH@AC.DAL.CA

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!SIUMED.EDU!clawyer
From: clawyer@SIUMED.EDU (Carl Lawyer)
Newsgroups: bionet.software
Subject: Re: Visible Human
Date: 2 Dec 1994 15:25:56 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 28
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <9412022314.AA28368@siumed.edu>
NNTP-Posting-Host: net.bio.net

At  7:08 PM 12/2/94 +0000, Janna Ore Nugent wrote:
>This week the National Library of Medicine unveiled
>Visible Man, the male componant of their Visible Human
>project.  Stories in the paper said that parts of Visible
>Man were already available on the Internet, but a source
>was not given.
>
>Does anybody know where to get Visible Man files on
>the Internet?  How about getting the whole 15 BG on
>tape?
>
>Thanks for any information,
>
>Janna Ore Nugent
>Visualization Lab Manager
>Biological Sciences Division
>The University of Chicago
>
>janna@bio-3.bsd.uchicago.edu

reply from C. Lawyer:

there are a few sample images available from

hyperdoc@nlm.nih.gov




From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!rutgers!mbcl!hey
From: hey@mbcl.rutgers.edu
Newsgroups: bionet.molbio.methds-reagnts,bionet.software
Subject: Dictating DNA sequences to a computer
Message-ID: <3930.2ed1da15@mbcl.rutgers.edu>
Date: 22 Nov 94 11:46:29 EDT
Lines: 84
Xref: biosci bionet.molbio.methds-reagnts:21653 bionet.software:10238

Dictating DNA sequences.

   I thought others might be interested in the way I have recently been 
entering DNA sequence data, from autoradiograms, to a computer.  The system is 
easier than using a digitizer, and comprably priced if you already own a quick 
PC clone (probably cheaper, I have not recently priced audio digitizers). 

The components:

Quick PC clone microcomputer (I use a 486 66Mhz Dell) with at least 16 meg 
RAM.

IBM OS/2 2.1 or 3.0  operating system.

IBM Personal Dication System for OS/2:
   This includes a hardware component, (a plug in card), a 
   microphone, and a software component.  The hardware and software sell 
   separately and both are about $500. I bought mine thru Indelible Blue 
   (800-776-8284). Contact IBM, not me, for more info.

Rimstar programmer's editor - OS/2 version. 
   Rimstar Technology Inc. (603) 778-2500.  This is also available thru 
   Indelible Blue or directly from the company.


How it works:

   The dicatation system works in two modes, dicatation and application 
control.  The dictation mode is nifty and very impressive, with a 30,000 word 
vocabulary that can be augmented. However in my experience it is not ideal for 
entering DNA sequence data.  Instead I use the application control feature of 
the dictation system.  This is basically a system whereby navigation through 
applications and windows that are open within the graphical interface of OS/2 
is done by dicatation of commands.  Under application control, the dictation 
software only recognizes a relatively small set of words, i.e. those that 
currently make sense for the windows that are open.  It is also quite easy to 
dictate macros to add additional functions to application control.

   It turns out that the Rimstar editor can be directed quite well under 
application control dictation. Furthermore this editor is highly configurable, 
and has a full featured macro language (very much like C) with a built in 
compiler.  What I have done is to create a set of dictation macros so 
that I can speak a small set of commands that cause the editor to write the 
different bases of a DNA sequence.  Each dictation macro triggers a macro 
function written in the Rimstar macro language.
   The different commands I use are associated with the following functions:
   - write 'A' and beep at  800 hz for 150 millisecs.
   - write 'C' and beep at 1200 hz for 150 millisecs.
   - write 'G' and beep at 1500 hz for 150 millisecs.
   - write 'T' and beep at 1800 hz for 150 millisecs.
   - write 'N' and beep at 400 hz for 150 millisecs.
   - delete the previous character and beep twice.
   
   The beeping provides an audio cue that the editor has received the 
intended command. All other Rimstar menu commands are also accessible by 
dictation. In particular "save" is frequently used to save the file.

   Any choice of words can be used for these functions, including the simple 
words "A", "C" etc.  However the dictation system does require clear speech 
with at least very short pauses between spoken commands. In practice I have 
found a different set of words to be more forgiving of vagaries in speech and 
less likely to be mistaken as other Rimstar menu commands. I use 
   - "ALL" for the A function.
   - "CHEESE" for the C function.
   - "GRAIN" for the G function.
   - "TICK" for the T function.
   - "N" for the N function.
   - "BACKSPACE" for the delete function.

   Probably the biggest downside to all this is that you sound a little goofy.

   By the way, Rimstar also makes a great sequence editor, especially for 
multiple sequences.  It has essentially unlimited line lengths, very easy 
column blocking and movement, and is highly configureable.  Brian Smith, the 
author has even written a macro that causes the four letters A, C, G and T to 
appear in different colors. Very handy for allignements.

Jody Hey
Department Biological Sciences
Rutgers University
hey@mbcl.rutgers.edu


   

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!spool.mu.edu!uwm.edu!vixen.cso.uiuc.edu!usenet.ucs.indiana.edu!sunflower.bio.indiana.edu!gilbertd
From: gilbertd@sunflower.bio.indiana.edu (Don Gilbert)
Newsgroups: bionet.software
Subject: Re: NCBI Vibrant Toolkit
Date: 2 Dec 1994 13:22:10 GMT
Organization: Biology, Indiana University - Bloomington
Lines: 10
Distribution: world
Message-ID: <3bn722$ib0@usenet.ucs.indiana.edu>
References: <9412011859.AA09572@nightshade.cit.cornell.edu>
NNTP-Posting-Host: sunflower.bio.indiana.edu

I use NCBI toolkit, esp. Vibrant, for cross-platform app
development, and it works well.  I prefer C++ and have a C++
application framework based in part on MacApp and built on
top of the NCBI toolkit.   See
  ftp://ftp.bio.indiana.edu/util/dclap/...
for this software source and demo applications.

-- don
-- 
-- d.gilbert--biocomputing--indiana u--bloomington--gilbertd@bio.indiana.edu

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!rutgers!gatech!swrinde!pipex!sunsite.doc.ic.ac.uk!daresbury!bioftp.unibas.ch!doelz
From: doelz@comp.bioz.unibas.ch (Reinhard Doelz)
Subject: Re: NCBI Vibrant Toolkit
Message-ID: <1994Dec2.182029.15148@comp.bioz.unibas.ch>
Organization: EMBnet Switzerland [Basel]
X-Newsreader: TIN [version 1.2 PL2]
References: <9412011859.AA09572@nightshade.cit.cornell.edu>
Date: Fri, 2 Dec 1994 18:20:29 GMT
Lines: 66

Edie Paul (epaul@NIGHTSHADE.CIT.CORNELL.EDU) wrote:
: I will soon be undertaking the development of a graphical user interface
: that I would like to run on multiple platforms, particularly UNIX and MS
: Windows.  I am considering the Vibrant toolkit for this, but I'd be
: interested in hearing any pros/cons/comments anyone has, 
[..]

We use VIBRANT as platform on OSF/1, IRIX, Mac, Windows, and AXP/VMS. 
It is a quite convenient toolkit and certainly worth looking at as an 
alternative to commercial products. Depending on the sophisticatedness 
you might need to invest some time as the callbacks require a lot of 
programming but this is an effect of a GUI and inherent to the method. 

Before you start on Windows, make sure you select a proper compiler - 
we got it running on both Visual C++ from Microsoft (16 bit) and Borland
C++ on the Win32s, but did not look in detail into other products. 
The 'make' utility should be supported as we had problems with Turbo C
from Borland. On the Macintosh we use Think C and successfully solved the small 
problems with the MacTCP package which you must have purchased separately.

We have investigated SUIT as an alternative (University of Virginia), 
but the SUIT routines are much lower-level and require even more 
programming work. Tk/tcl is also an alternative but not necessarily 
a brilliant option if you want to distribute your code as the client 
or remote user must have this installed if he/she wants to run your code.
Check out the Portable GUI Development Kit FAQ from news.answers (Author
Wade Guthrie) for a comprehensive overview including commercial packages.
(SUIT does not currently on Macintosh, which renders it useless for us).

A remark on developing with UNIX/Windows source code compatible systems; 
32 bit programming makes things a lot easier as memory models play a 
significantly smaller role, so if you can afford to force your users 
to go for the extensions then it might be worth to do so. 

There are quite a few demo examples coming with the NCBI distribution. 
VIBRANT non-NCBI examples are available from Don Gilbert's kit in C++. 

Our code is in ftp://bioftp.unibas.ch/archive_data/survival/csource, 
to see how the binaries look on different platforms check out Entrez
or use our code example we developed as part of the Survival Guide, on
ftp://bioftp.unibas.ch/archive_data/survival/binaries. We published 
another piece of code which is a very simple application of VIBRANT, see
ftp://bioftp.unibas.ch/programs/bioftp-sw/Dbcomp/bin for the various 
platforms and ftp://bioftp.unibas.ch/programs/bioftp-sw/Dbcomp/src for
source. Dbcomp was developed by F.Eggenberger in our lab. The sources
are in C as we are programming on today's zoo of all operating systems -
let us know if the code does not run on any of the VIBRANT-supported 
platforms. Without heating the C++ vs Smalltalk vs C war, yes we tried
all of them but C seems to be the only (affordable) language currently.
(In terms of ease of use, API's to other software, licensing fees, 
availability of CASE tools in public domain etc.)

Closing, we appreciate that NCBI makes VIBRANT available and thank the 
developers there, in particular Jonathan Kahns,  for their support.

Regards
Reinhard Doelz
EMBnet Switzerland



-- 
 R.Doelz         Klingelbergstr.70| Tel. x41 61 267 2247  Fax x41 61 267 2078|
 Biocomputing        CH 4056 Basel| electronic Mail    doelz@ubaclu.unibas.ch|
 Biozentrum der Universitaet Basel|-------------- Switzerland ---------------|
<a href=http://beta.embnet.unibas.ch/>EMBnet Switzerland:info@ch.embnet.org</a> 

From owner-software@net.bio.net Thu Dec 01 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!uchinews!bio-7.bsd.uchicago.edu!janna
From: janna@bio-7.bsd.uchicago.edu (Janna Ore Nugent)
Subject: Visible Human
Message-ID: <1994Dec2.190834.4409@midway.uchicago.edu>
Keywords: Visible Human, Visible Man
Sender: news@uchinews.uchicago.edu (News System)
Organization: Biological Sciences Division, The University of Chicago
Date: Fri, 2 Dec 1994 19:08:34 GMT
Lines: 18

This week the National Library of Medicine unveiled 
Visible Man, the male componant of their Visible Human
project.  Stories in the paper said that parts of Visible
Man were already available on the Internet, but a source
was not given.

Does anybody know where to get Visible Man files on
the Internet?  How about getting the whole 15 BG on
tape?

Thanks for any information,

Janna Ore Nugent
Visualization Lab Manager
Biological Sciences Division
The University of Chicago

janna@bio-3.bsd.uchicago.edu

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!agate!usenet.ins.cwru.edu!news.ecn.bgu.edu!newspump.wustl.edu!cerberus-138.wustl.edu!usenet
From: HAVILAND@KIDS.WUSTL.EDU (David L. Haviland, Ph.D.)
Newsgroups: bionet.software
Subject: Re: Bibliography package
Date: 2 Dec 1994 22:59:42 GMT
Organization: Washington University School of Med.
Lines: 22
Distribution: world
Message-ID: <3bo8su$l5n@cerberus-138.wustl.edu>
References: <dpogue.32.0017D550@obsnsrv1.bio.uoknor.edu> <3blrck$idt@news.mic.ucla.edu>
NNTP-Posting-Host: kids2.wustl.edu
X-News-Reader: VMS NEWS v1.25
In-Reply-To: visick@ewald.mbi.ucla.edu's message of 2 Dec 1994 00:56:52 GMT

In <3blrck$idt@news.mic.ucla.edu> visick@ewald.mbi.ucla.edu writes:

>  Darrell Pogue, dpogue@obsnsrv1.bio.uoknor.edu writes:
> >I am looking for a bibliography package for windows.  Any suggestions?
> 
> EndNote is the best, hands down.  It's not "for" Windoze, but
> it will run under Windoze, if you must.

Having tried BOTH Endnote and Papyrus, I beg to differ.  Though neither one 
is designed for Windows, in MY hands Papyrus was easier to use, easier to 
customize, and interacted with WordPerfect better than Endnote did.  I 
returned Endnote and never looked back.

Papyrus is also quite a bit cheaper than its competition.  No extra 
"modules" needed.  A Windows version is forthcoming after the Mac version 
is released - or so I've been told.

David
*Other than a satisfied customer, not affilied with RSD in any way...*




From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!ix.netcom.com!netnews
From: QZAR@ix.netcom.com (charles foulk)
Newsgroups: bionet.software
Subject: PCB CAD PROGRAM NEEDED
Date: 3 Dec 1994 16:03:04 GMT
Organization: Netcom
Lines: 8
Distribution: world
Message-ID: <3bq4ro$gqu@ixnews1.ix.netcom.com>
NNTP-Posting-Host: ix-orl2-22.ix.netcom.com

I am looking for a shareware or simalar pcb design program for turning 
schematics into track layouts
Anyone got any ideads?

Thanks

Zac :)


From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!boulder!tali.hsc.colorado.edu!news
From: ikled@njc.org (David Ikle)
Newsgroups: bionet.software
Subject: Re: Visible Human
Date: 3 Dec 1994 14:18:01 GMT
Organization: National Jewish Hospital
Lines: 7
Sender: -Not-Authenticated-[7598]
Distribution: world
Message-ID: <3bpump$iij@tali.hsc.colorado.edu>
References: <9412022314.AA28368@siumed.edu>
NNTP-Posting-Host: 198.243.65.21
X-Posted-From: InterNews 1.0.4@198.243.65.21
Xdisclaimer: No attempt was made to authenticate the sender's name.

Try http://www.nlm.nih.gov and select the Visible Human Project.

David N. Ikle, Ph.D.
Biostatistics and Academic Computing
National Jewish Hospital
Denver, CO 80206
ikled@njc.org

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!agate!boulder!tali.hsc.colorado.edu!news
From: ikled@njc.org (David Ikle)
Newsgroups: bionet.software
Subject: eXodus experience
Date: 3 Dec 1994 14:30:27 GMT
Organization: National Jewish Hospital
Lines: 11
Sender: -Not-Authenticated-[7598]
Message-ID: <3bpve3$ioa@tali.hsc.colorado.edu>
NNTP-Posting-Host: 198.243.65.21
X-Posted-From: InterNews 1.0.4@198.243.65.21
Xdisclaimer: No attempt was made to authenticate the sender's name.

Does anyone have an opinion on White Pine eXodus XWindows emulator?

Is it netive PowerPC yet?

How does it compare to MacX?

David N. Ikle, Ph.D.
Biostatistics and Academic Computing
National Jewish Hospital
Denver, CO 80206
ikled@njc.org

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!europa.eng.gtefsd.com!portal.gmu.edu!mason1.gmu.edu!dsklarew
From: dsklarew@mason1.gmu.edu (Daniel M Sklarew)
Newsgroups: bionet.software
Subject: Re: FREE INTERNET PROVIDERS
Date: 3 Dec 1994 08:34:04 GMT
Organization: George Mason University, Fairfax, Virginia, USA
Lines: 14
Message-ID: <3bpahs$mrr@portal.gmu.edu>
References: <3biuaq$ejj@speedy.interbahn.com>
NNTP-Posting-Host: mason1.gmu.edu
Mime-Version: 1.0
Content-Type: text/plain; charset=US-ASCII
Content-Transfer-Encoding: 7bit
X-Newsreader: TIN [version 1.2 PL2]

info (info@interbahn.com) wrote:

: : FREE INTERNET ACCESS
: : Full service Internet gateway
: : Includes shell and slip accounts
: : local dial up in most areas of U.S.A.
: : for full info dial via modem:  914-365-0179
: : reply by E-mail to info@interbahn.com
:   or telnet:   Interbahn.com

This is a crock -- they'll give you so many free days of service if you
sign up for their pay-service. Basically, false and deceptive 
advertising. Where's the Internet Better Business Bureau???


From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!swrinde!ihnp4.ucsd.edu!news.service.uci.edu!buggus.mmg.uci.edu!user
From: mangalam@uci.edu (Harry Mangalam)
Newsgroups: bionet.software
Subject: Re: Mac or PC: the results of the poll
Date: Fri, 02 Dec 1994 18:39:14 -0800
Organization: Microbiology and  Molecular Genetics, UC Irvine
Lines: 18
Message-ID: <mangalam-0212941839140001@buggus.mmg.uci.edu>
References: <3bfkl1$ro0@lirmm.lirmm.fr> <3bhr5h$6dc@sat.ipp-garching.mpg.de> <3bk6od$9lp@lyra.csx.cam.ac.uk> <jbuberel-0112941319220001@holzwarth3.life.uiuc.edu>
NNTP-Posting-Host: buggus.mmg.uci.edu

> I do believe that at the conference held by Apple-IBM-Motorola a few weeks
> ago to announce their Hardware Reference Platform they said it would run
> the following OS's:  Mac OS (obviously), Windows NT (this I've already
> seen running), AIX, and Solaris.
> 
> -jason

and os/2, PowerOpen (PPC/more open version of AIX?), taligent, and of course, 

LINUX!! (probably before some of the others).

-- 
  Harry J Mangalam, Microbiology and Molecular Genetics, 
    College of Medicine, UC Irvine, Irvine, CA, 92717, 
         (714) 824-4824, fax (714) 824 8598,
 --- That which does not kill me, makes me grouchier ---
         http://hornet.mmg.uci.edu/~hjm/hjm.html
Computational Biology..SGI..Woodworking..Bicycling..Linux..WWW 

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!uwm.edu!msunews!netnews.upenn.edu!news.drexel.edu!dunx1.ocs.drexel.edu!dunx1.ocs.drexel.edu!not-for-mail
From: st93mey7@dunx1.ocs.drexel.edu (Frederick Thum)
Newsgroups: bionet.software
Subject: Re: Visible Human
Date: 3 Dec 1994 18:38:12 -0500
Organization: Drexel University, Phila. Pa.
Lines: 21
Message-ID: <3bqvh4$t59@dunx1.ocs.drexel.edu>
References: <1994Dec2.190834.4409@midway.uchicago.edu>
NNTP-Posting-Host: dunx1.ocs.drexel.edu
X-Newsreader: TIN [version 1.2 PL2]

Janna Ore Nugent (janna@bio-7.bsd.uchicago.edu) wrote:
: This week the National Library of Medicine unveiled 
: Visible Man, the male componant of their Visible Human
: project.  Stories in the paper said that parts of Visible
: Man were already available on the Internet, but a source
: was not given.

Michael J. Ackerman is the Project Director.  I do not have his email 
address available, although it should not be difficult to find.

: Does anybody know where to get Visible Man files on
: the Internet?  How about getting the whole 15 BG on
: tape?

From the correspondence I have received thus far, the files are available
to individuals after they sign a licensing agreement (still free, though).
The complete set is available on DAT for a $1,000 processing fee.

Contact Ackerman for details.

- Fred Thum

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!ns1.faseb.org!darwin.sura.net!tulane!Dean.Bottino
From: bottino@math.tulane.edu (Dean Bottino)
Newsgroups: bionet.software
Subject: amoeboid locomotion visualization
Date: 3 Dec 1994 23:01:58 GMT
Organization: Computer Science Dept., Tulane Univ., New Orleans, LA
Lines: 12
Sender: -Not-Authenticated-[3898]
Message-ID: <3bqtd6$3ii@news.cs.tulane.edu>
NNTP-Posting-Host: ppp9.tcs.tulane.edu
X-Posted-From: InterNews 1.0@news.cs.tulane.edu.
Xdisclaimer: No attempt was made to authenticate the sender's name.

I was wondering where I could access some movies (quicktime, etc) of
amoeboid locomotion.  Many articles I am reading mention movies
presented at conferences, etc...  I would like to see them.  I am
working on a computer model of such locomotion and I wanted to get a
better idea of what the things look like when they're moving.

If there aren't any computer movies out there, is there a way to get
information about movies on videotape?  Mathematicians don't watch many
movies, so I'm kind of clueless on this.

Thanks.   
     bottino@math.tulane.edu

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!panix!cmcl2!yale.edu!yale!loglady.ninds.nih.gov!johnk
From: johnk@spasm.niddk.nih.gov (John Kuszewski)
Newsgroups: bionet.software
Subject: Re: OB-GYN and Astronomy Software for PCs
Date: 30 Nov 1994 21:06:45 GMT
Organization: National Insts. of Health
Lines: 30
Distribution: world
Message-ID: <3biph5$m0a@babyblue.cs.yale.edu>
References: <3bhse7$5kd@newsbf01.news.aol.com>
Reply-To: johnk@spasm.niddk.nih.gov (John Kuszewski)
NNTP-Posting-Host: spasm.niddk.nih.gov

In article <3bhse7$5kd@newsbf01.news.aol.com>, alexkara@aol.com (AlexKara) writes:
|> Hi all,
|> 
|> I'd like to know if there is any type of OB-GYN software or Astrology (Not
|> Astronomy) software out there in the market.
|> 
|> I can't seem to find anything in the stores, since they are concentrating
|> on the games and non-serious software.  Please forgive me if this isn't
|> the right news group for this kind of posting, but I really don't know
|> where else to look.
|> 
|> Please advise, thank you in advance...
|> 
|> Alex K.

Another fine posting brought to you by AOL.

-- 
                                   _____________
                                   |        ___/_
                                   |        |/  /
                                   --  /\  //  /--
                                   ||  ||  /  /||
                                   ||  || /  / ||
                                   ||  ||/  /  ||
John Kuszewski                     ||  |/  /|  ||      
johnk@spasm.niddk.nih.gov          ||  /  /||  ||
                                   \/ /  / ||  \/
that's MISTER protein G to you!     |/__/|      |
                                      /_________|

From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!pipex!uunet!news.uiowa.edu!panda
From: J. Monahan <jmonahn@blue.weeg.uiowa.edu>
Newsgroups: bionet.software
Subject: Re: Digital Imaging Software and Hardware
Date: 3 Dec 1994 19:29:32 GMT
Organization: U of Iowa Panda System
Lines: 31
Distribution: world
Message-ID: <786483286-1-51539@blue.weeg.uiowa.edu>
References: <umdoble-2411942301430001@dyn1-085.cc.umanitoba.ca>
Reply-To: jmonahn@blue.weeg.uiowa.edu
NNTP-Posting-Host: blue.weeg.uiowa.edu

The free software called "Image" is available for the Mac from the anon. ftp 
site:  zippy.nimh.nih.gov
I believe it can do the analysis you need. Also, you can use a digitizing 
board with a mac, Video Spigot, for example, to capture single frames of video 
to be opened in the image analysis software. 
Joe Monahan


In note <umdoble-2411942301430001@dyn1-085.cc.umanitoba.ca>, 
umdoble@mail.cc.umanitoba.ca (Brad Doble) writes: 
>Our lab currently has a microscope equipped with a CCD colour video camera
>and colour monitor.   We would like to store images (videocassette
>recorder?) and then analyze them using a computer (we currently have a
>computer with a 66 MHz 486 processor, 8 Megabytes RAM, 250 MB hard drive,
>and a standard svga graphics card).   What additional hardware (RAM,
>graphics cards, hard disk space, etc.) is required, and what good software
>programs are currently in use to analyze image data?  The types of
>analyses we would like to do include: i) counting labelled or stained
>cells vs. control cells ;  ii) measuring the intensity of fluorescent
>markers; iii) determing morphometric values; etc.   The purchase of
>another computer may be possible with our budget so please don't hesitate
>to describe setups with Macintoshes if you feel they are best for the task
>at hand.   Also, I would like to have an idea of the cost of the hardware
>and software required.
>
>Any feedback will be greatly appreciated. 
>
>                              Thanks in advance,
>
>                              Brad Doble


From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!pipex!uunet!news.uiowa.edu!panda
From: J. Monahan <jmonahn@blue.weeg.uiowa.edu>
Newsgroups: bionet.software
Subject: Re: Font w/ male&female symbols wanted
Date: 3 Dec 1994 19:24:16 GMT
Organization: U of Iowa Panda System
Lines: 27
Distribution: world
Message-ID: <786482969-0-51539@blue.weeg.uiowa.edu>
References: <3ah0ur$iua@ixnews1.ix.netcom.com> <booth-2111941511470001@mac087.nhrc.navy.mil> <carmean-2411941145460001@creslab2.biol.sfu.ca>
Reply-To: jmonahn@blue.weeg.uiowa.edu
NNTP-Posting-Host: blue.weeg.uiowa.edu

The new system font available for the Mac has the font called "Zeal" that 
includes the male-female symbols. You have to load Zeal, open the Key Caps 
application that comes with the system software then depress the option key to 
see the symbols.

Joe Monahan



In note <carmean-2411941145460001@creslab2.biol.sfu.ca>, carmean@sfu.ca (Dave 
Carmean) writes: 
>I am looking for a (free?) font for Macintosh that includes 
>male and female symbols.  If you know of any (preferably with a
>FTP/gopher/WWW address) I would greatly appreciate the information.
>
>I am also curious why these seem to be missing from symbols- I would at
>least think the medical world would have some influence in their
>inclusion.  Or more cynically, the astrological world.
>
>Thanks in advance,
>Dave Carmean                    
>Biological Sciences              
>Simon Fraser University          
>Burnaby, BC  CANADA V5A 1S6
>
>carmean@sfu.ca


From owner-software@net.bio.net Fri Dec 02 22:00:00 1994
Path: biosci!ns1.faseb.org!darwin.sura.net!tulane!Dean.Bottino
From: bottino@math.tulane.edu (Dean Bottino)
Newsgroups: bionet.software
Subject: amoeboid locomotion visualization
Date: 3 Dec 1994 22:54:53 GMT
Organization: Computer Science Dept., Tulane Univ., New Orleans, LA
Lines: 9
Sender: -Not-Authenticated-[3898]
Message-ID: <3bqsvt$3bp@news.cs.tulane.edu>
NNTP-Posting-Host: ppp9.tcs.tulane.edu
X-Posted-From: InterNews 1.0@news.cs.tulane.edu.
Xdisclaimer: No attempt was made to authenticate the sender's name.

I was wondering where I could access some movies (quicktime, etc) of
amoeboid locomotion.  Many articles I am reading mention movies
presented at conferences, etc...  I would like to see them.  I am
working on a computer model of such locomotion and I wanted to get a
better idea of what the things look like when they're moving.

If there aren't any computer movies out there, is there a way to get
information about movies on videotape?  Mathematicians don't watch many
movies, so I'm kind of clueless on this.

From owner-software@net.bio.net Sat Dec 03 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!EU.net!ub4b!idefix.CS.kuleuven.ac.be!blekul11!jan.eggermont
Nntp-Posting-Host: 134.58.181.40
Date: Sat, 3 Dec 1994 13:59:33 +0100
From: Jan.Eggermont@med.kuleuven.ac.be (Jan Eggermont)
Newsgroups: bionet.software
Subject: Re: DNA Strider
Message-ID: <Jan.Eggermont-0312941405190001@134.58.181.40>
References: <3b0g10$4no@news.doit.wisc.edu>
Organization: KU Leuven
Lines: 24

In article <3b0g10$4no@news.doit.wisc.edu>, chih-che@cae.wisc.edu
(Chih-Che Lin) wrote:

> Hi there,
>         I am looking for a software named "DNA strider". If someone
>         out there happen to know this software, I will really
>         appreciate if you can tell me the company's phonenumber or
>         any information about this software.
>
>
You can contact the author on this address:

Christian Marck
Service de Biochimie et de Génétique Moléculaire
Bat 142  Centre d'Etudes de Saclay
91191 Gif-Sur-Yvette
France

--
Jan Eggermont                       Jan.Eggermont@med.kuleuven.ac.be
Laboratorium voor Fysiologie - KU Leuven
Campus Gasthuisberg
B-3000 Leuven                            tel 32-16-345938
Belgium                                  fax 32-16-345991

From owner-software@net.bio.net Sat Dec 03 22:00:00 1994
Path: biosci!newshost.lanl.gov!news.ttu.edu!news
From: P.Doris@ttu.edu (Peter Doris)
Newsgroups: bionet.software
Subject: Re: Visible Human
Date: 4 Dec 1994 16:35:24 GMT
Organization: Texas Tech University Health Sciences Center
Lines: 9
Sender: -Not-Authenticated-[4153]
Message-ID: <3bsr4c$q33@hydra.acs.ttu.edu>
References: <1994Dec2.190834.4409@midway.uchicago.edu>  
 <3bqvh4$t59@dunx1.ocs.drexel.edu>
NNTP-Posting-Host: cbb056.lubb.ttuhsc.edu
X-Posted-From: InterNews 1.0.2b3@cbb056.lubb.ttuhsc.edu
Xdisclaimer: No attempt was made to authenticate the sender's name.

sample files can be obtained by gopher to gopher.nlm.nih.gov	(port 70) 

they are gif format and about 250K each

there is one sample file for each body region

Peter A. Doris
P.Doris@ttu.edu
(806) 743 3046             

From owner-software@net.bio.net Sat Dec 03 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!vixen.cso.uiuc.edu!holzwarth3.life.uiuc.edu!user
From: jbuberel@uiuc.edu (Jason L. Buberel)
Newsgroups: bionet.software
Subject: Re: Digital Imaging Software and Hardware
Date: Sun, 04 Dec 1994 12:12:12 -0600
Organization: Universtiy of Illinois
Lines: 68
Distribution: world
Message-ID: <jbuberel-0412941212120001@holzwarth3.life.uiuc.edu>
References: <umdoble-2411942301430001@dyn1-085.cc.umanitoba.ca> <786483286-1-51539@blue.weeg.uiowa.edu>
NNTP-Posting-Host: holzwarth3.life.uiuc.edu

In article <786483286-1-51539@blue.weeg.uiowa.edu>,
jmonahn@blue.weeg.uiowa.edu wrote:

> The free software called "Image" is available for the Mac from the anon. ftp 
> site:  zippy.nimh.nih.gov
> I believe it can do the analysis you need. Also, you can use a digitizing 
> board with a mac, Video Spigot, for example, to capture single frames of
video 
> to be opened in the image analysis software. 
> Joe Monahan
> 
> 
> In note <umdoble-2411942301430001@dyn1-085.cc.umanitoba.ca>, 
> umdoble@mail.cc.umanitoba.ca (Brad Doble) writes: 
> >Our lab currently has a microscope equipped with a CCD colour video camera
> >and colour monitor.   We would like to store images (videocassette
> >recorder?) and then analyze them using a computer (we currently have a
> >computer with a 66 MHz 486 processor, 8 Megabytes RAM, 250 MB hard drive,
> >and a standard svga graphics card).   What additional hardware (RAM,
> >graphics cards, hard disk space, etc.) is required, and what good software
> >programs are currently in use to analyze image data?  The types of
> >analyses we would like to do include: i) counting labelled or stained
> >cells vs. control cells ;  ii) measuring the intensity of fluorescent
> >markers; iii) determing morphometric values; etc.   The purchase of
> >another computer may be possible with our budget so please don't hesitate
> >to describe setups with Macintoshes if you feel they are best for the task
> >at hand.   Also, I would like to have an idea of the cost of the hardware
> >and software required.
> >
> >Any feedback will be greatly appreciated. 
> >
> >                              Thanks in advance,
> >
> >                              Brad Doble

I would second the reccomendation of using NIH Image for the macintosh. 
We have just recently gone into the digital imaging business, and have
been quite pleased.  We already had a camera and scope. To compliment
this, we purchased a frame grabber board for $800.  We threw the board
into a PowerMac 7100, and it works wonderfully.  Here are my reasons for
thinking this is a good idea:

1.  NIH Image is FREE.  It will do all the analyses that you mention. 
There are many freely available user programmed macros for doing even more
(like in situ grain counts), in addition to what you require. It even lets
you do time lapse video microscopy.  On top of all this, there is a native
Power Mac version available (which means it is fully accelerated for the
Power Mac...you should see it do 3-D texture maps).

2.  No other image analysis software is free.  At the recent neuroscience
conference in Miami, I looked into all the other vendors offering digital
image analysis software for mac and windows.  These programs were all a
bit fancier than NIH Image, but they started at about $1000.  Some of them
had some really high end features, but none of them offered the superior
price/performance that NIH Image can.

3.  The author of NIH Image, Wayne, is a great guy.  He answers your
questions via e-mail.  There is also a mailing list devoted to the use of
NIH Image, subscribed to by tons of more experienced NIH Image users, as
well as Wayne himself.  I don't think many other companies offer this kind
of free technical support.

4.  NIH Image creates standard TIFF image files.  So, if you really wanted
to, you could pass these images along to colleagues (sp?) using a DOS
Computer.

5.  There are many other programs on the PowerMac that you can use to: 
ready images for publication, archive, and enhance these TIFF files.

From owner-software@net.bio.net Sat Dec 03 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!newsxfer.itd.umich.edu!nntp.cs.ubc.ca!unixg.ubc.ca!ericjj
From: ericjj@unixg.ubc.ca (Eric Jay Jervis)
Newsgroups: bionet.software
Subject: Re: Bibliography package
Date: 4 Dec 1994 07:56:38 GMT
Organization: University of British Columbia, Vancouver, B.C., Canada
Lines: 2
Message-ID: <3brsnm$7cp@nnrp.ucs.ubc.ca>
References: <dpogue.32.0017D550@obsnsrv1.bio.uoknor.edu>
NNTP-Posting-Host: interchg.ubc.ca
X-Newsreader: TIN [version 1.2 PL2]

Darrell Pogue (dpogue@obsnsrv1.bio.uoknor.edu) wrote:
: I am looking for a bibliography package for windows.  Any suggestions?

From owner-software@net.bio.net Sat Dec 03 22:00:00 1994
Path: biosci!cc.UManitoba.CA!gordonr
From: gordonr@cc.UManitoba.CA (Richard Gordon)
Newsgroups: bionet.software
Subject: theoretical biology
Date: 4 Dec 1994 03:47:17 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 56
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <Pine.SUN.3.91.941204054440.13381B-100000@pollux.cc.umanitoba.ca>
References: <3bqtd6$3ii@news.cs.tulane.edu>
NNTP-Posting-Host: net.bio.net

International organization of theoretical biologists?
Dear Colleague:

We have been running a small Canadian Society Theoretical Biology (CSTB) 
for the past decade which has been attracting 1/3 international 
memberships. We charge only Can$25/yr for membership. We are at a 
critical juncture, needing new people to take active participation. With 
the cost of international travel and the lure of specialty conferences, 
it is difficult for us to get together physically. Yet there is a need 
for developing an intellectual community of like-minded scientists. 
Theoretical biologists are in a difficult position right now, perhaps 
analogous to theoretical physicists before quantum mechanics. There is 
great potential; we know the experimentalists need us; but in general 
they don't know that, and we have no niche.

We think it is time to rethink whether the CSTB should continue to 
identify itself as a Canadian organisation, or whether we should become 
more explicitly international. It seems that our common bond is not 
Canadian residency, but rather a common international interest in 
theoretical biology and a desire to communicate. The services we have 
been able to offer to our members include a Newsletter, reduced rate 
subscriptions to the Journal of Biological Systems, and an Email network. 
We need to redefine our role, keeping in mind that there already exist 
several other organisations with overlapping interests, such as the SMB 
(Society for Mathematical Biology). The distinction between theoretical 
biology and mathematical biology is discussed in:

Gordon, R. (1993). Careers in theoretical biology. Carolina Tips  56(3), 
9-11.

which might be a good point for beginning our deliberations. If you would 
like a copy of this just send a request to Dick Gordon at 
GordonR@cc.UManitoba.ca

You are all encouraged to contribute to our discussion, whether or not 
you are a member of CSTB at the present time.  Please send your comments to
CSTB@biome.bio.ns.ca 
so that we can continue this discussion.  To join, send the message

subscribe cstb

to Majordomo@biome.bio.ns.ca

Dick Gordon, CSTB President
Department of Radiology, University of Manitoba
Room ON104, Health Sciences Centre, 820 Sherbrook Street
Winnipeg, MB R3A 1R9 Canada
Phone: (204) 787-1076,  Fax: (204) 783-8565,  E-mail: GordonR@cc.UManitoba.ca

Bill Silvert, CSTB Secretary/Treasurer
Habitat Ecology Division (HED), Bedford Inst. of Oceanography
P. O. Box 1006, Dartmouth, Nova Scotia, CANADA B2Y 4A2.  Tel. (902)426-1577
InterNet Address: silvert@biome.bio.ns.ca                Fax  (902)426-2256
HED runs a WWW server at URL=http://biome.bio.dfo.ca



From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Newsgroups: bionet.software,comp.os.ms-windows.announce
Path: biosci!galaxy.ucr.edu!library.ucla.edu!europa.eng.gtefsd.com!howland.reston.ans.net!pipex!uunet!nih-csl!shiloh.nimh.nih.gov!sgraham
From: tjrc1@mole.bio.cam.ac.uk (Tim Cutts)
Subject: Refs 7.52: Bibliography software
X-Original-Submission-Date: 3 Dec 1994 14: 27:07 GMT
Message-ID: <1994Dec5.045400.21118@alw.nih.gov>
Followup-To: comp.os.ms-windows.misc
Originator: sgraham@shiloh.nimh.nih.gov
X-Submissions-To: win-announce@shiloh.nimh.nih.gov
Keywords: shareware, Windows 3.1, MedLine, bibliography
Lines: 77
Sender: tjrc1@mole.bio.cam.ac.uk
Organization: University of Cambridge, England
Date: Mon, 5 Dec 1994 04:54:00 GMT
Approved: sgraham@shiloh.nimh.nih.gov (Moderator)
X-Administrivia-To: coma-request@shiloh.nimh.nih.gov
Xref: biosci bionet.software:10257 comp.os.ms-windows.announce:856

I have uploaded the new version of my Refs bibliography package to the
following sites:

cyclin.zoo.cam.ac.uk:/pub/refs/refs752.zip

and it should also appear, once it gets moved from the uploads
directory, at:

ftp.cica.indiana.ed:/pub/pc/win3/util/refs752.zip

There is a World Wide Web page for Refs, from which you can obtain
screenshots, and of course the program itself:

http://cyclin.zoo.cam.ac.uk/pub/refs/

Here follows the readme for the program:

Refs 7.52
========

03 December 1994

Introduction
------------

Refs is a program for creating browsing and maintaining academic
reference databases.  The program uses the common ASCII Unix refer file
format and so is compatible with Unix refer, and also bibliography programs
such as WinRefer.

Refs can also import data files in other formats, in an easily expandable
way.  Modules are supplied to read ISI, Chemical Abstracts, Current Contents
and Medline files, and the help file includes details for writing your own
modules.

Refs is shareware, and the distribution should contain the following files:

	REFS.EXE        The program itself
	REFS.HLP        The help file
	REFS.INI        INI file
	REFEN.DLL       English language DLL
	BIDS.FLT        BIDS (ISI) Import filter
	MEDLINE.FLT     Medline Import filter
	CHEM.FLT        Chemical Abstracts filter
	CCRM.FLT        Current Contents Reference Manager filter
	CTL3D.DLL       Microsoft 3D library
	INSTALL.EXE     Installation program
	INSTALL.INI     Installation INI file.
	TEST.REF        Example Unix refer data file
	README.TXT      This file

The program will work with Windows 3.1 or higher.

Installation
------------

You will need PKUNZIP 2.04 or later to extract the ZIP file.

1. Extract this file into a spare directory.
2. Run INSTALL.EXE, which will install the program automatically.

NB.  INSTALL will notice an existing REFS.INI file and will back it up
if required.

Helpful suggestions, registrations and/or bug reports should be sent to:

tjrc1@cus.cam.ac.uk

T J R Cutts
194, Vinery Rd
Cambridge
CB1 3DS
UK

The registration fee is 30 pounds sterling, with discounts for multiple
registrations.  More details can be found in the help file.


From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!usenet.ucs.indiana.edu!sunflower.bio.indiana.edu!gilbertd
From: gilbertd@sunflower.bio.indiana.edu (Don Gilbert)
Newsgroups: bionet.software
Subject: Re: Looking for DNA sequence analysis programs that are freeware
Date: 5 Dec 1994 22:14:25 GMT
Organization: Biology, Indiana University - Bloomington
Lines: 21
Message-ID: <3c03c1$ntp@usenet.ucs.indiana.edu>
References: <jv27-051294092404@132.236.8.122>
NNTP-Posting-Host: sunflower.bio.indiana.edu

There are various macintosh, msdos/mswin, unix and some other computer
system programs for DNA sequence analysis available at the
archive sites including ftp.bio.indiana.edu (by anonymous ftp or gopher).  
Several of these are free, some are shareware, and there are a few demos
of commercial programs here.

One of the free ones, called SeqApp, for Macintoshes, was written by Don 
Gilbert (me).  See the molbio/seqapp/ folder at the above archive.  
Another mac sequence analysis program you might try is 'dnastacks'


I beleive that Will Gilbert, currently at U.New Hampshire,
also wrote a sequence editor for VMS computers a while back, and it
may have been called something like seqed.  There are probably several
sequence editors with a name something like that (programmers
frequently name their software functionally, and not always very
originally).

-- Don
-- 
-- d.gilbert--biocomputing--indiana u--bloomington--gilbertd@bio.indiana.edu

From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Path: biosci!rutgers!gatech!swrinde!news.uh.edu!uhdvx3.dt.uh.edu!islam_y
From: islam_y@uhdvx3.dt.uh.edu (Yasir, 640388286)
Newsgroups: bionet.software
Subject: Re: DNASTAR vs. GENECODES
Date: 5 Dec 1994 16:17 CST
Organization: University of Houston-Downtown
Lines: 23
Distribution: world
Message-ID: <5DEC199416175751@uhdvx3.dt.uh.edu>
References: <199411182350.PAA21026@netcomsv.netcom.com> <1994Nov28.132237.17697@liberty.uc.wlu.edu>
NNTP-Posting-Host: uhdvx3.dt.uh.edu
X-Lunar-Date: 0 days, 1 hour, 0 minutes since the new moon
News-Software: VAX/VMS VNEWS 1.42    

In article <1994Nov28.132237.17697@liberty.uc.wlu.edu>, cjh@helix.nih.gov (C.J. Hussussian, MD) writes...
>We have experience in our lab using both DNAStar and Sequencher from
>Gene Codes. For the purposes of assembly and editing of sequences
>generated on the ABI, Sequencher has by far the best interface. This
>comes from the ability to view multiple stacked and aligned
>chromatograms for instant checking of discordant bases. While DNAStar
>allows viewing of chromatograms, they are not aligned and one wastes
>time searching for the base in question. In addition, Sequencher has an
>automatic vector removal feature which is very flexible, allowing one
>to define any sequence as "vector". We find this useful in removing our
>primer sequences prior to analysis. DNAStar comes with other modules
>which offer functionality beyond sequence assembly (and beyond what
>Sequencher provides), including good multiple alignment and primer
>picking tools. We generally do our sequence assembly and editing in
>Sequencher, then export text files to DNAStar for further analysis.
> 
>Chris Hussussian, MD
>NIH/NCHGR
>Bldg. 49, Rm. 4A83
>Bethesda, MD  20892
>ph: (301)402-2029
>fax: (301)402-5602
>e-mail: cjh@helix.nih.gov

From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Path: biosci!agate!spool.mu.edu!caen!news.tc.cornell.edu!travelers.mail.cornell.edu!newsstand.cit.cornell.edu!NewsWatcher!user
From: jv27@cornell.edu (Joyce Van Eck)
Newsgroups: bionet.software
Subject: Looking for DNA sequence analysis programs that are freeware
Followup-To: bionet.software
Date: 5 Dec 1994 14:27:16 GMT
Organization: Cornell University
Lines: 6
Sender: jv27@cornell.edu (Verified)
Message-ID: <jv27-051294092404@132.236.8.122>
NNTP-Posting-Host: 132.236.8.122

We have been informed that DNA sequence anaysis programs which are in the
public domain (freeware) are available on the Internet.  We would be
interested in the names of any of these programs and where we can find
them. Might one of these programs be entitled SEQ.ED (by Gilbert?)?

Thank you!

From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Path: biosci!agate!spool.mu.edu!bloom-beacon.mit.edu!usc!cs.utexas.edu!howland.reston.ans.net!ix.netcom.com!netnews
From: shayashi@ix.netcom.com (Shigenari Hayashi)
Newsgroups: bionet.software
Subject: Re: Sequence comparison
Date: 5 Dec 1994 08:06:45 GMT
Organization: Netcom
Lines: 50
Distribution: world
Message-ID: <3buhml$287@ixnews1.ix.netcom.com>
References: <tchoi-221194152656@romulan.bio.brandeis.edu>
NNTP-Posting-Host: ix-sf5-21.ix.netcom.com

In <tchoi-221194152656@romulan.bio.brandeis.edu> 
tchoi@binah.cc.brandeis.edu (Giltsu Choi) writes: 

>
>I would like know there is any software
>that I can use my study. here's my situation.
>
>I have 2kb upstream of A gene from two related species
>and 2kb upstream of B gene from a species. B gene is
>coordinately regulated with A gene in terms of
>expression pattern. Now I want to do some sequence
>comparisons to extract information such as
>possible sequence elements for the regulation of these genes.
>Is it possible to extract such things?
>If it is, is there any program or any methods I can use?
>If there isn't, is there any scientists whom I can talk?
>
>I'll appreciate your help.
>
>Sincerely,
>Giltsu Choi
>

There are several ways in which you can perform such an analysis.
While there are several different email servers which will 
search for possible regulatory regions in a queried sequence, 
you may find it easier (and more applicable to the situation 
that you detailed), to first analyze your sequences for regions 
of similarity.  There are several software programs that will search for 
similarities in different sequences, depending upon the type of platform 
you're utilizing (i.e. Unix / DOS / etc.).  Upon determining these 
regions(s) in your sequences, you can utilize a "consensus" sequence as 
a query for the previously mentioned email server search.

Feel free to contact me if you have any further questions:

E-mail: shayashi@mercury.sfsu.edu
        shayashi@ix.netcom.com

------------------------------------------------------------------------ 
  ----------------------- Information is power ---------------------
      ---------------------- only when utilized ------------------
         ----------------------- appropriately! ---------------
            ------------------------------------------------

-- 
Shigenari Hayashi

E-mail: shayashi@ix.netcom.com
        shayashi@mercury.sfsu.edu

From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Path: biosci!rutgers!gatech!swrinde!news.uh.edu!uhdvx3.dt.uh.edu!islam_y
From: islam_y@uhdvx3.dt.uh.edu (Yasir, 640388286)
Newsgroups: bionet.software
Subject: Re: DNASTAR vs. GENECODES
Date: 5 Dec 1994 16:21 CST
Organization: University of Houston-Downtown
Lines: 26
Distribution: world
Message-ID: <5DEC199416210131@uhdvx3.dt.uh.edu>
References: <199411182350.PAA21026@netcomsv.netcom.com> <1994Nov28.132237.17697@liberty.uc.wlu.edu>
NNTP-Posting-Host: uhdvx3.dt.uh.edu
X-Lunar-Date: 0 days, 1 hour, 1 minute since the new moon
News-Software: VAX/VMS VNEWS 1.42    

In article <1994Nov28.132237.17697@liberty.uc.wlu.edu>, cjh@helix.nih.gov (C.J. Hussussian, MD) writes...
>We have experience in our lab using both DNAStar and Sequencher from
>Gene Codes. For the purposes of assembly and editing of sequences
>generated on the ABI, Sequencher has by far the best interface. This
>comes from the ability to view multiple stacked and aligned
>chromatograms for instant checking of discordant bases. While DNAStar
>allows viewing of chromatograms, they are not aligned and one wastes
>time searching for the base in question. In addition, Sequencher has an
>automatic vector removal feature which is very flexible, allowing one
>to define any sequence as "vector". We find this useful in removing our
>primer sequences prior to analysis. DNAStar comes with other modules
>which offer functionality beyond sequence assembly (and beyond what
>Sequencher provides), including good multiple alignment and primer
>picking tools. We generally do our sequence assembly and editing in
>Sequencher, then export text files to DNAStar for further analysis.
>send

>Chris Hussussian, MD
>NIH/NCHGR
>Bldg. 49, Rm. 4A83
>Bethesda, MD  20892
>ph: (301)402-2029


>fax: (301)402-5602
>e-mail: cjh@helix.nih.gov

From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Path: biosci!rutgers!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!newsrelay.iastate.edu!news.iastate.edu!pv3209.vincent.iastate.edu!srinum
From: srinum@iastate.edu (SRINIVAS MUMMIDI)
Newsgroups: bionet.software
Subject: PHYLIP and PAUP programs
Date: 5 Dec 94 19:55:31 GMT
Organization: Iowa State University, Ames, Iowa
Lines: 15
Message-ID: <srinum.786657331@pv3209.vincent.iastate.edu>
NNTP-Posting-Host: pv3209.vincent.iastate.edu

Dear Netters:
	Can somebody help me in obtaining the following software
packages:
1) Phylogeny Inference Package (PHYLIP) version 3.4 and
2) Phylogenetic analysis using parsimony (PAUP) version 3.0.

	Any information including telephone numbers, addresses etc.,
will be helpful. Thank you.

						Srinivas Mummidi
-- 
SRINIVAS MUMMIDI
srinum@iastate.edu		Voice:(515)-294-6932(W);(515)-233-8071(H)
301, So.5th APT#304	 	Fax:(515)-294-1401				
Ames IA 50011

From owner-software@net.bio.net Sun Dec 04 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!lhc!nih-csl!stimpy!owhite
From: owhite@stimpy.tigr.org (smouldering dog)
Subject: hydrophbicity programs
Message-ID: <1994Dec5.225137.7724@alw.nih.gov>
Sender: owhite@stimpy (smouldering dog)
Organization: National Institutes of Health
Date: Mon, 5 Dec 1994 22:51:37 GMT
Lines: 7

I am looking for C-code for hydrophobicity calculation in peptides.
If anyone could direct me to a site containing same that would be
greatly appreciated.

	Thank you,
	Owen White
	The Institute for Genomic Research

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!pipex!uknet!strath-cs!nntphost.dur.ac.uk!vega.dur.ac.uk!dbl3isd
From: I S Downie <I.S.Downie@durham.ac.uk>
Newsgroups: bionet.software
Subject: Re: Pentium Jokes...
Date: 6 Dec 1994 12:25:46 GMT
Organization: University of Durham, Durham, UK.
Lines: 12
Message-ID: <3c1l8a$g9l@mercury.dur.ac.uk>
References: <jbuberel-3011941726420001@holzwarth2.life.uiuc.edu>
NNTP-Posting-Host: vega.dur.ac.uk
X-Newsreader: TIN [version 1.2 PL2]


: Q:  What do you call a series of FDIV instructions on a Pentium?
: A:  Successive approximations.

: Q:  What algorithm did Intel use in the Pentium's floating point divider?
: A:  "Life is like a box of chocolates." (Source: F. Gump of Intel)


Good ones!
Praise from another anti-Pentium bod!

Iain

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!pipex!uunet!zib-berlin.de!informatik.tu-muenchen.de!lrz-muenchen.de!ipp-garching.mpg.de!alf.biochem.mpg.de!krasel
From: krasel@alf.biochem.mpg.de (Cornelius Krasel)
Newsgroups: bionet.software
Subject: Re: hydrophbicity programs
Date: 6 Dec 1994 10:18:51 GMT
Organization: Rechenzentrum der Max-Planck-Gesellschaft in Garching
Lines: 15
Message-ID: <3c1dqb$1498@sat.ipp-garching.mpg.de>
References: <1994Dec5.225137.7724@alw.nih.gov>
NNTP-Posting-Host: alf.biochem.mpg.de
X-Newsreader: TIN [version 1.2 PL2]

smouldering dog (owhite@stimpy.tigr.org) wrote:
> I am looking for C-code for hydrophobicity calculation in peptides.
> If anyone could direct me to a site containing same that would be
> greatly appreciated.

A very simple C program is appended to the original article by Kyte
and Doolittle (JMB 157, 105-132, 1982).

--Cornelius.


--
/* Cornelius Krasel, Abt. Lohse, Genzentrum, D-82152 Martinsried, Germany  */
/* email: krasel@alf.biochem.mpg.de                 fax: +49 89 8578 3795  */
/* "Science is the game you play with God to find out what His rules are." */

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!usc!howland.reston.ans.net!pipex!uunet!heifetz.msen.com!zib-berlin.de!informatik.tu-muenchen.de!bensch
From: bensch@Informatik.TU-Muenchen.DE (Ewald Bensch)
Newsgroups: bionet.software,bit.general,biz.sco.general
Subject: FORTRAN to programming flowchart
Date: 6 Dec 1994 08:44:53 GMT
Organization: Technische Universitaet Muenchen, Germany
Lines: 27
Distribution: world
Message-ID: <3c18a5$3om@hpsystem1.informatik.tu-muenchen.de>
NNTP-Posting-Host: hphalle1a.informatik.tu-muenchen.de
X-newsreader: xrn 7.00
Xref: biosci bionet.software:10265 biz.sco.general:11625


Hey.

I'm surching for a tool with the subsequent spezification:

A FORTRAN-source-program (or C-program) should be visualised as a
programming flowchart.

The output should be possible into an ASCII-file, as a postscript-file
or as a screendump.

FORTRAN77 (or FORTRAN66) should be handled (if it can handle Fortran90,
it is perfectly qualified).

I'm mostly interested to visualise GOTO-branches and jumps, to detect
the programmflow.

If you know the name of such a tool, who sales it, how much must I pay
(public domain or licensed), then please give me answer via email to:

      bensch@sdm.de


Bye.

Bensch


From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!news2.near.net!das-news2.harvard.edu!fas-news.harvard.edu!nucleus!robison
From: robison@nucleus.harvard.edu (Keith Robison)
Newsgroups: bionet.software
Subject: .GDEmenus code for ClustalW
Date: 6 Dec 1994 23:04:40 GMT
Organization: Harvard University, Cambridge, Massachusetts
Lines: 18
Message-ID: <3c2qm8$dq4@decaxp.harvard.edu>
NNTP-Posting-Host: nucleus.harvard.edu
X-Newsreader: TIN [version 1.2 PL2]

Has anyone out there interfaced ClustalW to GDE?  Did you write specific
menus?  Could I steal them?

(hint to UNIX software developers: since GDE is pretty popular, it wouldn't
be a bad idea to include in your distribution the relevant GDE menu code 
for your programs).

Thanks for any help.

Keith Robison
Harvard University
Department of Cellular and Developmental Biology
Department of Genetics / HHMI

robison@mito.harvard.edu 




From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!bloom-beacon.mit.edu!gatech!swrinde!pipex!sunic!news.lth.se!news.lu.se!news!bolde
From: bolde@biogen.wblab.lu.se (Bjšrn Olde)
Subject: PCR-program for degenerate primers
Message-ID: <bolde.1137117697A@news.lu.se>
Followup-To: bionet.software
Sender: news@nomina.lu.se (USENET News System)
Nntp-Posting-Host: bjorno.wblab.lu.se
Organization: Molecular Neurobiology, Wallenberg Lab., Lund, Sweden
X-Newsreader: VersaTerm Link v1.1
Date: Tue, 6 Dec 1994 16:07:37 GMT
Lines: 7

Where do I find a program that can be used in the design of degenerate
PCR-primers? I would prefer a macintosh program.

Bjorn Olde 
Molecular Neurobiology
Wallenberg Laboratory
Sweden

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!europa.eng.gtefsd.com!library.ucla.edu!ucsbuxb.ucsb.edu!poole
From: poole@lifesci.ucsb.edu (poole)
Newsgroups: bionet.software
Subject: HyperChem on Irix5.2
Date: 6 Dec 1994 21:24:49 GMT
Organization: University of California, Santa Barbara
Lines: 6
Sender: -Not-Authenticated-[3870]
Message-ID: <3c2kr1$lru@ucsbuxb.ucsb.edu>
NNTP-Posting-Host: poole.lscf.ucsb.edu
X-Posted-From: InterNews 1.0@ucsbuxb.ucsb.edu.
Xdisclaimer: No attempt was made to authenticate the sender's name.

Our version of HyperChem for SGI (which unfortunately is no longer
supported by the publishers) died when we went from IRIX 4.X to IRIX
5.2. If anyone has successfully installed HyperChem running under IRIX
5, I would appreciate knowing that it is possible.

Stephen Poole   poole@lifesci.ucsb.edu

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!europa.eng.gtefsd.com!newsxfer.itd.umich.edu!gumby!wmichgw!458atkins
From: BrianC.Atkins@wmich.edu
Newsgroups: bionet.software
Subject: ------>ATTENTION ALL PREMEDS!!!!!
Message-ID: <1994Dec6.180050.24968@wmichgw>
Date: 6 Dec 94 18:00:50 EDT
Organization: Western Michigan University
Lines: 14

Fellow Premeds:
        I trust that I share with you the goal of scoring well on the April
'95 MCAT.  I posted earlier asking for recommendations regarding a software
package that could help prepare me for the coming quiz, and met such an
overwhelming response that I was struck with an idea---
        If you use the Macintosh platform, and are interested in a communal
profit with your competition, email me for information.  I AM NOT TRYING
TO MAKE MONEY!  I am merely trying to save money while preparing myself to
present the best possible application to my target schools!  I hope you will
join me, so that you might do the same!

Brian C. Atkins,
Junior premed, Western Michigan University
BrianC.Atkins@wmich.edu

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!MAILGATE.GLAXO.COM!agostino~mj%a1.usa.umc
From: agostino~mj%a1.usa.umc@MAILGATE.GLAXO.COM ("Mike Agostino")
Newsgroups: bionet.software
Subject: how many receptors are there?
Date: 6 Dec 1994 12:27:27 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 27
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <43329160214991.324212@USA>
NNTP-Posting-Host: net.bio.net

[This message is converted from WPS-PLUS to ASCII]

There have been a lot of numbers kicked around, based on various
techniques for estimating gene frequencies, that put the total
number of G-protein coupled receptors encoded by the human genome
at anywhere from a couple of hundred to several thousand.

Does anyone out there in Netland have what they are comfortable
with as a number for GPCR's?  Or, do you have any idea where some
of these estimates came from?  If so, could you post or email me
with it and please include where the estimate came from and how
it was derived (no astrology, please).  I realize that all of
these estimates have an element of fantasy to them, so I promise
not to publish or otherwise attribute an estimate to you unless
you beg appropriately.

It would probably be most useful to break it down into total and
non-odorant/sensory receptors.


I will post back to the net a summary of replies (with names
omitted unless otherwise requested).

Thanks,

Rich Buckholz
RGB12955@glaxo.com

From owner-software@net.bio.net Mon Dec 05 22:00:00 1994
Path: biosci!rutgers!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!usenet.ucs.indiana.edu!sunflower.bio.indiana.edu!gilbertd
From: gilbertd@sunflower.bio.indiana.edu (Don Gilbert)
Newsgroups: bionet.software,bionet.drosophila
Subject: IUBio archive & FlyBase service outage
Date: 6 Dec 1994 21:36:43 GMT
Organization: Biology, Indiana University - Bloomington
Lines: 13
Message-ID: <3c2lhb$psd@usenet.ucs.indiana.edu>
NNTP-Posting-Host: sunflower.bio.indiana.edu
Xref: biosci bionet.software:10271 bionet.drosophila:721

IUBio Archive & the FlyBase services, at ftp.bio.indiana.edu, are not
available this afternoon.  I hope to have them back on-line in a few hours.
The outage is due to a hardware upgrade and unexpected problems
from the upgrade.  Details: a long SCSI disk chain developed termination
or signal problems, and corrupted the system disk.

Note that tomorrow morning (5am EST ...) the IP address changes from 
129.79.224.25 to 129.79.225.25.  At this time also there may be a service 
interruption, as I have to change the computer hostname.

-- Don
-- 
-- d.gilbert--biocomputing--indiana u--bloomington--gilbertd@bio.indiana.edu

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!rutgers!uwm.edu!psuvax1!news.cc.swarthmore.edu!mac04.parrishd.swarthmore.edu!user
From: ehom1@cc.swarthmore.edu (Erik Forbes Y. Hom '95)
Newsgroups: bionet.software
Subject: Question about Mulfold (M. Zuker et al.'s)
Followup-To: bionet.software
Date: Wed, 07 Dec 1994 14:35:33 +0000
Organization: Laboratory of Neurobiology, Swarthmore College
Lines: 17
Message-ID: <ehom1-071294143533@mac04.parrishd.swarthmore.edu>
NNTP-Posting-Host: mac04.parrishd.swarthmore.edu
Mime-Version: 1.0
Content-Type: text/plain; charset=US-ASCII
Content-Transfer-Encoding: 7bit

Hi netters!  I have a copy of mulfold for the Mac.  A limitation of this
version: one can only fold a 300 base sequence.  I, however, have a
sequence of ~4000 that I want to fold to see if the start codon or SD
domain could potentially interact with bases more distant than the
neighboring ~150 bases (and the effect of mutations in these more distant
domains on this interaction).  Is there anyway I could do this without
constructing some chimeric sequence between the initiation region and the
distant region of interest (I don't think the results I would get from this
would be very realistic)?  Do you thing it is reasonable
(thermodynamically) for a such a distant region (say ~500 bases away) to
base pair with the initiation region?  (I can't, for certain, justify one
or the other because I can't do the folding!).  What are the limitations
for the UNIX version??  Help!  Thanks for your time!

Yours truly,

erik

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!rutgers!gatech!swrinde!pipex!uunet!zib-berlin.de!gs.dfn.de!news.uni-bielefeld.de!techfak.uni-bielefeld.de!fuellen
From: fuellen@techfak.uni-bielefeld.de (Georg Fuellen)
Subject: Re: [wanted] computer dictionaries, biology, ecogoly, zoology...
Sender: news@hermes.hrz.uni-bielefeld.de (News Administrator)
Message-ID: <D0FxAq.JE3@hermes.hrz.uni-bielefeld.de>
Date: Wed, 7 Dec 1994 12:28:02 GMT
References:  <D0FBF0.z9@ucc.su.OZ.AU>
Nntp-Posting-Host: moos.techfak.uni-bielefeld.de
Organization: Universitaet Bielefeld, Technische Fakultaet.
Lines: 40

Re: [wanted] computer dictionaries, biology, ecogoly, zoology...

A small Molecular Genetics glossary is at http://www.gdb.org/Dan/DOE/prim6.html
It is part of the document http://www.gdb.org/Dan/DOE/intro.html

>>>>
Primer on Molecular Genetics 
(Department of Energy)
This primer was prepared by Denise Casey (Human Genome Management Information System - Oak Ridge National
Laboratory) for the 1991-92 DOE Human Genome Program Report and modified for Web access by Dan Jacobson.
The primer is now being extensively revised and updated by HGMIS. 
<<<<

I'd be interested in any other pointers people may have.

kindest regards,
  georg
fuellen@dali.Mathematik.Uni-Bielefeld.DE
fuellen@Techfak.Uni-Bielefeld.DE
fuellen@MIT.EDU
    Dr Stephen R Covey, The 7 Habits of Highly Effective People, Habit #3:
    Put First Things First !
    More information on the GNA-VSNS Biocomputing Course ca be found at
    http://www.techfak.uni-bielefeld.de/techfak/persons/fuellen/BCChome.html

In article <D0FBF0.z9@ucc.su.OZ.AU>, ginster@magna.com.au writes:
|> I'm very interested in finding some good dictionaries in a form accessable
|> from on a computer, which give definitions of the words we would not
|> usually find in your normal dictionary. These definitions, pertaining
|> to biological sciences, and even geological sciences would be extreamly
|> useful to me and my research.
|> 
|> I am even offering to have this kind of thing available on the WWW, but
|> I need the text. Obviously this is a big request, but instead of starting
|> from scratch, I wondered if anyone here can help.
|> 
|>  any suggestions would be great. thanks in advance,
|> 
|> Ginny
|> ginster@magna.com.au

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!rutgers!gatech!newsxfer.itd.umich.edu!caen!hearst.acc.Virginia.EDU!murdoch!dayhoff.med.Virginia.EDU!wrp
From: wrp@dayhoff.med.Virginia.EDU (William R. Pearson)
Subject: PowerPC performance
Message-ID: <D0G76q.GrB@murdoch.acc.Virginia.EDU>
Sender: usenet@murdoch.acc.Virginia.EDU
Organization: University of Virginia
Date: Wed, 7 Dec 1994 16:01:38 GMT
Lines: 39


	I am in the process of converting the programs in the FASTA
package over to the PowerPC and would like to share some observations.
When I first converted FASTA to the PowerPC version, the speed-up over
the 68K version was very modest, only about 33%.  I then compared
FASTA on the PPC to FASTA on an IBM RS/6000 with AIX (same
architecture, different speeds and operating systems).  I was dismayed
that a FASTA search that took about 7 sec on the Unix RS/6K took more
than 2 minutes on the PPC.

	Since the Unix system has a sophisticated preemptive
scheduling mechanism and the MacPPC requires frequent poling to
simulate multiprocessing, I checked to see whether my event checking
routine was responsible for some of the difference.  It was; removing
the ChkEvent() routine decreased the time required from > 2 minutes to
about 22 sec (on a PowerMac 8100/80).  Still not as good as Unix, but
in the ballpark.  I have since modified the ChkEvent() routine to poll
the system only once per second, and the performance loss is modest
(28 vs 22 sec).  Here, the MacPPC was so fast that it spent 80% of its
time doing system polling and only 20% on my application.

	FASTA may also be slower on the Mac because of inefficiencies
in the file system (and remember, the Unix time is a CPU time, not
elapsed, so i/o time is not included, however that adds only about 1
sec).  To focus on the relative CPU performance, I searched the PIR1
database with SSEARCH, which implements the Smith-Waterman algorithm.
Here the results were much more impressive; the MacPPC took about 8
min while the Unix RS/6K took 6. Thus, for very CPU-intensive tasks,
the 80 Mhz PowerMac performs about 75% as well as an IBM RS/6000 model
370.  I suspect that performance scales well with clock speed on the
MacPPC, so that the ~$2500 model 7100 (66 Mhz) would be equivalent to
about 60% of a 370 (a 62 MHz chip set) at about 10% the price.

Bill Pearson
-- 
wrp@virginia.EDU
Dept. of Biochemistry #440
U. of Virginia
Charlottesville, VA 22908

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!daresbury!sunsite.doc.ic.ac.uk!lyra.csx.cam.ac.uk!moose.bioc.cam.ac.uk!user
From: nef@mole.bio.cam.ac.uk (Nick Fisher)
Newsgroups: bionet.software
Subject: "Good Times" e-mail virus is a HOAX
Date: Wed, 07 Dec 1994 17:50:46 +0000
Organization: Cambridge University (Biochemistry Department)
Lines: 11
Message-ID: <nef-0712941750460001@moose.bioc.cam.ac.uk>
NNTP-Posting-Host: moose.bioc.cam.ac.uk


The so-called "Good Times" e-mail virus is a HOAX. It is IMPOSSIBLE for a
text file to infect your computer. Only executable files can carry
"active" virus code. The single purpose of this "virus" is to flood the
Net with warnings posted by well-meaning people worried about computer
security.

Nick Fisher
Dept of Biochemistry 
Cambridge University
UK

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!daresbury!not-for-mail
From: Dietmar Tietz <Dietmar.Tietz@agrar.uni-giessen.de>
Newsgroups: bionet.software
Subject: Re: !!!!Warning: a virus is emailed (fwd)
Date: 7 Dec 1994 14:04:32 -0000
Lines: 147
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <3c4fdg$3li@mserv1.dl.ac.uk>
X-Sender: gh43@hamster.hrz.uni-giessen.de
MIME-Version: 1.0
Original-To: bioforum@dl.ac.uk, bio-soft@dl.ac.uk, bio-info@dl.ac.uk


After mailing the first message, I received the following note stating 
that there is no "good times" email virus.  I am sorry for any 
inconvenience this false alarm might have caused.  I posted the virus 
alert, since it arrived from a usually reliable source.

Dietmar Tietz
---------- Forwarded message ----------

=============================================================================

             U.S. DOE's Computer Incident Advisory Capability
           ___  __ __    _     ___           __  __ __   __   __
          /       |     /_\   /       |\ |  /  \   |    |_   /_
          \___  __|__  /   \  \___    | \|  \__/   |    |__  __/

Number 94-04                                                December 6, 1994

 ------------------- A - T - T - E - N - T - I - O - N -------------------
|  CIAC is available 24-hours a day via its two skypage numbers.  To use  |
|  this service, dial 1-800-759-7243.  The PIN numbers are: 8550070 (for  |
|  the CIAC duty person) and 8550074 (for the CIAC manager).  Please keep |
|  these numbers handy.                                                   |
 -------------------------------------------------------------------------

Welcome to the fourth issue of CIAC Notes!  This is a special edition to
clear up recent reports of a "good times" virus-hoax.  Let us know if you
have topics you would like addressed or have feedback on what is useful and
what is not.  Please contact the editor, Allan L. Van Lehn, CIAC,
510-422-8193 or send E-mail to ciac@llnl.gov. 

  $-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$
  $ Reference to any specific commercial product does not necessarily   $
  $ constitute or imply its endorsement, recommendation or favoring by  $
  $ CIAC, the University of California, or the United States Government.$
  $-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$

THE "Good Times" VIRUS IS AN URBAN LEGEND

In the early part of December, CIAC started to receive information requests
about a supposed "virus" which could be contracted via America OnLine, simply
by reading a message.  The following is the message that CIAC received: 

 ---------------------------------------------------------------------------
| Here is some important information. Beware of a file called Goodtimes.    |
|                                                                           |
|  Happy Chanukah everyone, and be careful out there. There is a virus on   |
| America Online being sent by E-Mail.  If you get anything called "Good    |
| Times", DON'T read it or download it.  It is a virus that will erase your |
| hard drive.  Forward this to all your friends.  It may help them a lot.   |
 ---------------------------------------------------------------------------

THIS IS A HOAX.  Upon investigation, CIAC has determined that this message
originated from both a user of America Online and a student at a university
at approximately the same time, and it was meant to be a hoax. 

CIAC has also seen other variations of this hoax, the main one is that any
electronic mail message with the subject line of "xxx-1" will infect your
computer. 

This rumor has been spreading very widely.  This spread is due mainly to the
fact that many people have seen a message with "Good Times" in the header. 
They delete the message without reading it, thus believing that they have
saved themselves from being attacked. These first-hand reports give a false
sense of credibility to the alert message. 

There has been one confirmation of a person who received a message with
"xxx-1" in the header, but an empty message body.  Then, (in a panic, because
he had heard the alert), he checked his PC for viruses (the first time he
checked his machine in months) and found a pre-existing virus on his machine.
 He incorrectly came to the conclusion that the E-mail message gave him the
virus (this particular virus could NOT POSSIBLY have spread via an E-mail
message).  This person then spread his alert. 

As of this date, there are no known viruses which can infect merely through
reading a mail message.  For a virus to spread some program must be executed.
Reading a mail message does not execute the mail message.  Yes, Trojans have
been found as executable attachments to mail messages, the most notorious
being the IBM VM Christmas Card Trojan of 1987, also the TERM MODULE Worm
(reference CIAC Bulletin B-7) and the GAME2 MODULE Worm (CIAC Bulletin B-12).
 But this is not the case for this particular "virus" alert. 

If you encounter this message being distributed on any mailing lists, simply
ignore it or send a follow-up message stating that this is a false rumor. 

Karyn Pichnarczyk
CIAC Team
ciac@llnl.gov


- ------------------------------
Contacting CIAC

If you require additional assistance or wish to report a vulnerability, call
CIAC at 510-422-8193, fax messages to 510-423-8002 or send E-mail to
ciac@llnl.gov.  For emergencies and off-hour assistance, call 1-800-SKY-PAGE
(759-7243) and enter PIN number 8550070 (primary) or 8550074 (secondary). 
The CIAC Duty Officer, a rotating responsibility, carries the primary
skypager. The Project Leader carries the secondary skypager.  If you are
unable to contact CIAC via phone, please use the skypage system. 

- ------------------------------
This document was prepared as an account of work sponsored by an agency of
the United States Government.  Neither the United States Government nor the
University of California nor any of their employees, makes any warranty,
express or implied, or assumes any legal liability or responsibility for the
accuracy, completeness, or usefulness of any information, apparatus, product,
or process disclosed, or represents that its use would not infringe privately
owned rights.  Reference herein to any specific commercial products, process,
or service by trade name, trademark, manufacturer, or otherwise, does not
necessarily constitute or imply its endorsement, recommendation or favoring
by the United States Government or the University of California.  The views
and opinions of authors expressed herein do not necessarily state or reflect
those of the United States Government or the University of California, and
shall not be used for advertising or product endorsement purposes. 

- ------------------------------
End of CIAC Notes Number 94-04  94_12_06
****************************************

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+-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-+
| Juergen Obermann           Hochschulrechenzentrum der         |
| Tel: +49-641-702-2169      Justus-Liebig-Universitaet Giessen |
| E-Mail: Juergen.Obermann   Heinrich-Buff-Ring 44              |
|      @hrz.uni-giessen.de   D-35392 Giessen                    |
+-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-.-+

******************************************************************
*           Dietmar Tietz, Ph.D.,  Research Scientist            *
*            Biostatistics, Justus-Liebig-University             *
*            Ludwigstr. 27, D-35390 Giessen, Germany             *
*                  Phone: +49-(641)-702-9733                     *
*                   Fax: +49-(641)-702-9724                      *
*              Email: Dietmar.Tietz@Uni-Giessen.de               *
******************************************************************


From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!pipex!warwick!bham!bcm39.bham.ac.uk!j.d.brinck
From: j.d.brinck@bham.ac.uk (Jason Brinck)
Newsgroups: bionet.software
Subject: Re: !!!!Warning: a virus is emailed (fwd)
Date: Wed, 7 Dec 1994 14:40:15
Organization: The University of Birmingham
Lines: 40
Distribution: bionet
Message-ID: <j.d.brinck.42.000EAC35@bham.ac.uk>
References: <3c414j$l80@mserv1.dl.ac.uk> <3c4alu$iru@lyra.csx.cam.ac.uk>
NNTP-Posting-Host: bcm39.bham.ac.uk
X-Newsreader: Trumpet for Windows [Version 1.0 Rev A]

In article <3c4alu$iru@lyra.csx.cam.ac.uk> tjrc1@mole.bio.cam.ac.uk (Tim Cutts) writes:
>From: tjrc1@mole.bio.cam.ac.uk (Tim Cutts)
>Subject: Re: !!!!Warning: a virus is emailed (fwd)
>Date: 7 Dec 1994 12:43:42 GMT

>Dietmar Tietz <Dietmar.Tietz@agrar.uni-giessen.de> writes:


>>>
>>> A virus is circulating on the Internet.  If you receive a message with
>>> the header "xxx-1" DO NOT READ IT.  Delete immediately or your disk will
>>> require treatment by a virus-scanner.  I have had two copies of this
>>> message this morning (Sunday) already, but was warned by an early
>>> morning phone call from a friend who got hit.
>>>
>>>************************************************************************

>>>>This crossed my virtual desk this afternoon.  Does anyone have more info?
>>>>
>>>>>>> Somebody is sending e-mail under the title "good times".  If you get
>>>>>>anything
>>>>>>> like this, DON'T DOWNLOAD THE FILE! ! ! ! ! ! ! ! ! ! It has a
>>>virus that
>>>>>>> rewrites your hard drive, and you lose anything on your hard
>>>drive.  Pleas
>>>e
>>>>>>> be careful and forward this mail to anyone you care about!

>Please could we not have such scare stories?  Such a virus is indeed a
>worry, but there's no point in panicking everyone.  Who dies the virus
>affact?  PC users?  Mac users?  Unix users?  I find it very hard to
>believe that there is any sort of virus that will affect any system
>regardless of operating system/mail handler used.  Please be more
>specific.

>Tim.

No need to panic! This is a hoax



From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!pipex!lyra.csx.cam.ac.uk!sunsite.doc.ic.ac.uk!daresbury!hgmp.mrc.ac.uk!abrown
From: abrown@crc.ac.uk (Mr. A. Brown)
Newsgroups: bionet.software
Subject: FAQ
Date: 7 Dec 1994 13:38:03 GMT
Organization: MRC Human Genome Resource Centre
Lines: 10
Message-ID: <3c4drr$ctl@mercury.hgmp.mrc.ac.uk>
NNTP-Posting-Host: tin.hgmp.mrc.ac.uk

Can any body e-mail me a copy of the FAQ for this news-group, or
at least tell me where I can get hold of one??

==
Alex Brown,                              e-mail: abrown@hgmp.mrc.ac.uk
MRC Collaborative Centre,                      : a-brown@nimr.mrc.ac.uk
1-3 Burtonhole Lane,                     Tel.  : 081-906 3811
Mill Hill, London NW7 1AD. U.K.          Fax.  : 081-906 1395



From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!daresbury!s-ind1!lhb
From: lhb@s-ind1.dl.ac.uk (L. H. Bell)
Newsgroups: bionet.software
Subject: Re: .GDEmenus code for ClustalW
Date: 7 Dec 1994 13:23:19 GMT
Organization: SERC Daresbury Lab, Warrington, U.K.
Lines: 182
Sender: lhb@s-ind1 (L. H. Bell)
Distribution: world
Message-ID: <3c4d07$h9@mserv1.dl.ac.uk>
References: <3c2qm8$dq4@decaxp.harvard.edu>
Reply-To: lhb@seqnet.dl.ac.uk
NNTP-Posting-Host: s-ind1.dl.ac.uk

In article <3c2qm8$dq4@decaxp.harvard.edu>, robison@nucleus.harvard.edu (Keith Robison) writes:
|> Has anyone out there interfaced ClustalW to GDE?  Did you write specific
|> menus?  Could I steal them?
|>

Heres one - it writes the clustalw command line into a shell script so it can be run
in batch. It was written for the SGI version of gde output into.

Hope this helps,

Lachlan Bell
SEQNET

http://www.dl.ac.uk/SEQNET/home.html

(PS, if you spot any 'features' please e-mail them to me.)


#********** 
item: clustalw
#********** 
# 
# Run clustalw. Open output file with  editor. Run another gde with 
# clustalw output as input. Remove all created files! 
#
# Did funny naming of arguments because gde was getting confused with
# variables that with similar names or the same names as in previous items:
#
# Supposedly takes gde format but I get 'Sequence format is unknown' when I try
#
itemmethod:(readseq in1 -a -p -f=nbrf>in1.cl;header.sh>in1.com; echo  clustalw /output=GDE /outfile=$NAM /outorder=$ORDER /CASE=$BZA /infile=in1.cl /PWMATRIX=$XX /PWGAPOPEN=$YY /PWGAPEXT=$ZZ /align /MATRIX=$WW /GAPOPEN=$STZZ /GAPEXT=$TS /ENDGAPS=$CGH /GAPDIST=$KIK $PAS $HYDRO /MAXDIV=$EYQ /SCORE=$MNE /TYPE=$ASDA $TRANS \> in1.rpt>>in1.com; $BATCH)&

itemhelp:clustalw_help

in:in1
informat:genbank

arg:BATCH
argtype:choice_menu
arglabel:Submit to batch?
argchoice:Big:echo $RM in1* >> in1.com ;qsub -q big in1.com
argchoice:Small:echo $RM in1* >> in1.com ;qsub -q fast in1.com
argchoice:Interactive: echo '$REPORT' >> in1.com ; chmod 0700 in1.com ; in1.com ;$RM in1.cl in1.com ;$GDE $NAM
argvalue:0

arg:NAM
argtype:text
arglabel:Put output in which file?
argtext:clustalw_out

arg:ASDA
argtype:chooser
arglabel:Sequence type?
argchoice:Protein:PROTEIN
argchoice:DNA/RNA:DNA

arg:REPORT
argtype:chooser
arglabel:View assembly report?
argchoice:No:
argchoice:Yes:/exe1/bin/emacs in1.rpt&

arg:BZA
argtype:chooser
arglabel:Should the residues be in -
argchoice:Upper Case:upper
argchoice:Lower Case:lower

arg:ORDER
argtype:choice_menu
arglabel:Should the output order be -
argvalue:0
argchoice:Same as input order:input
argchoice:In alignment order:aligned

arg:XX
argtype:choice_menu
arglabel:Use what matrix for pairwise aligning
argvalue:2
argchoice:PAM:PAM
argchoice:MD:MD
argchoice:BLOSUM:BLOSUM

arg:WW
argtype:choice_menu
arglabel:Use what matrix for multiple aligning
argvalue:2
argchoice:PAM:PAM
argchoice:MD:MD
argchoice:BLOSUM:BLOSUM

arg:YY
argtype:slider
arglabel:gap open penalty (pairwise)
argmin:1
argmax:100
argvalue:10

arg:ZZ
argtype:text
arglabel:gap extending penalty (pairwise) [0.0-1.0]
argtext:0.10

arg:STZZ
argtype:slider
arglabel:gap open penalty (multiple)
argmin:1
argmax:100
argvalue:10

arg:TS
argtype:text
arglabel:gap extending penalty (multiple) [0.0-1.0]
argtext:0.5

arg:TRANS
argtype:chooser
arglabel:DNA transitions weighted?
argvalue:0
argchoice:No:
argchoice:Yes:/TRANSITIONS

arg:CGH
argtype:chooser
arglabel:Penalise end gaps?
argvalue:0
argchoice:No:NO
argchoice:Yes:YES

arg:HYDRO
argtype:chooser
arglabel:Hydrophilic gaps?
argvalue:0
argchoice:On:
argchoice:Off:/NOHGAP

arg:PAS
argtype:chooser
arglabel:Pascarella gaps?
argvalue:
argchoice:On:
argchoice:Off:/NOPGAP

arg:MNE
arg:argtype:choice_menu
arglabel:Scoring Method
argchoice:Absolute:absolute
argchoice:Percentage:percentage

arg:KIK
argtype:slider
arglabel:gap separation penalty range?
argmin:1
argmax:100
argvalue:8

arg:EYQ
argtype:slider
arglabel:% ident. for delay?
argmin:1
argmax:100
argvalue:40

#
# This takes a list as the argument therefore can't do
#
#arg:HRES
#argtype:chooser
#arglabel:List hydrophilic residues?
#argvalue:0
#argchoice:No:
#argchoice:Yes:/HGAPRESIDUES

-----------start of header.sh
#!/bin/csh -f
# this first line needed
echo "#\!/bin/csh -f"
# set up movement to the current directory. This will be the one with
# the input file in it.
echo cd $cwd
# the program & parameters are echoed from control line in gde
------------end of header.sh

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!spool.mu.edu!howland.reston.ans.net!swrinde!pipex!sunsite.doc.ic.ac.uk!daresbury!not-for-mail
From: "Bill Kupiec" <kupiec@mail1.ciwemb.edu>
Newsgroups: bionet.software
Subject: Re: !!!!Warning- a virus is
Date: 7 Dec 1994 14:10:15 -0000
Lines: 135
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <3c4fo7$41h@mserv1.dl.ac.uk>
Original-To: "Bio Software" <bio-software@dl.ac.uk>

>> A virus is circulating on the Internet.  If you receive a message with
>> the header "xxx-1" DO NOT READ IT.  Delete immediately or your disk will
>> require treatment by a virus-scanner.  I have had two copies of this
>> message this morning (Sunday) already, but was warned by an early
>> morning phone call from a friend who got hit.
>>************************************************************************
>>>This crossed my virtual desk this afternoon.  Does anyone have more info?
>>>
>>>>>> Somebody is sending e-mail under the title "good times".  If you get
>>>>>anything
>>>>>> like this, DON'T DOWNLOAD THE FILE! ! ! ! ! ! ! ! ! ! It has a
>>virus that
>>>>>> rewrites your hard drive, and you lose anything on your hard
>>drive.  Pleas
>>e
>>>>>> be careful and forward this mail to anyone you care about!

>Date: Tue, 6 Dec 1994 15:23:09 -0800
>Message-Id: <199412062302.PAA23885@cheetah.llnl.gov>
>Reply-To: karyn@cheetah.llnl.gov
>Originator: ciac-notes@cheetah.llnl.gov
>Sender: ciac-notes@cheetah.llnl.gov
>From: Karyn Pichnarczyk <karyn@cheetah.llnl.gov>
>Subject: CIAC Notes 94-04
>
>
>             U.S. DOE's Computer Incident Advisory Capability
>           ___  __ __    _     ___           __  __ __   __   __
>          /       |     /_\   /       |\ |  /  \   |    |_   /_
>          \___  __|__  /   \  \___    | \|  \__/   |    |__  __/
>
>Number 94-04                                                December 6, 1994
>
> ------------------- A - T - T - E - N - T - I - O - N -------------------
>|  CIAC is available 24-hours a day via its two skypage numbers.  To use  |
>|  this service, dial 1-800-759-7243.  The PIN numbers are: 8550070 (for  |
>|  the CIAC duty person) and 8550074 (for the CIAC manager).  Please keep |
>|  these numbers handy.                                                   |
> -------------------------------------------------------------------------
>
>Welcome to the fourth issue of CIAC Notes!  This is a special edition to
>clear up recent reports of a "good times" virus-hoax.  Let us know if you
>have topics you would like addressed or have feedback on what is useful and
>what is not.  Please contact the editor, Allan L. Van Lehn, CIAC,
>510-422-8193 or send E-mail to ciac@llnl.gov.
>
>  $-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$
>  $ Reference to any specific commercial product does not necessarily   $
>  $ constitute or imply its endorsement, recommendation or favoring by  $
>  $ CIAC, the University of California, or the United States Government.$
>  $-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$-$
>
>THE "Good Times" VIRUS IS AN URBAN LEGEND
>
>In the early part of December, CIAC started to receive information requests
>about a supposed "virus" which could be contracted via America OnLine, simply
>by reading a message.  The following is the message that CIAC received:
>
> ---------------------------------------------------------------------------
>| Here is some important information. Beware of a file called Goodtimes.    |
>|                                                                           |
>|  Happy Chanukah everyone, and be careful out there. There is a virus on   |
>| America Online being sent by E-Mail.  If you get anything called "Good    |
>| Times", DON'T read it or download it.  It is a virus that will erase your |
>| hard drive.  Forward this to all your friends.  It may help them a lot.   |
> ---------------------------------------------------------------------------
>
>THIS IS A HOAX.  Upon investigation, CIAC has determined that this message
>originated from both a user of America Online and a student at a university
>at approximately the same time, and it was meant to be a hoax.
>
>CIAC has also seen other variations of this hoax, the main one is that any
>electronic mail message with the subject line of "xxx-1" will infect your
>computer.
>
>This rumor has been spreading very widely.  This spread is due mainly to the
>fact that many people have seen a message with "Good Times" in the header.
>They delete the message without reading it, thus believing that they have
>saved themselves from being attacked. These first-hand reports give a false
>sense of credibility to the alert message.
>
>There has been one confirmation of a person who received a message with
>"xxx-1" in the header, but an empty message body.  Then, (in a panic, because
>he had heard the alert), he checked his PC for viruses (the first time he
>checked his machine in months) and found a pre-existing virus on his machine.
> He incorrectly came to the conclusion that the E-mail message gave him the
>virus (this particular virus could NOT POSSIBLY have spread via an E-mail
>message).  This person then spread his alert.
>
>As of this date, there are no known viruses which can infect merely through
>reading a mail message.  For a virus to spread some program must be executed.
>Reading a mail message does not execute the mail message.  Yes, Trojans have
>been found as executable attachments to mail messages, the most notorious
>being the IBM VM Christmas Card Trojan of 1987, also the TERM MODULE Worm
>(reference CIAC Bulletin B-7) and the GAME2 MODULE Worm (CIAC Bulletin B-12).
> But this is not the case for this particular "virus" alert.
>
>If you encounter this message being distributed on any mailing lists, simply
>ignore it or send a follow-up message stating that this is a false rumor.
>
>Karyn Pichnarczyk
>CIAC Team
>ciac@llnl.gov
>
>
>------------------------------
>Contacting CIAC
>
>If you require additional assistance or wish to report a vulnerability, call
>CIAC at 510-422-8193, fax messages to 510-423-8002 or send E-mail to
>ciac@llnl.gov.  For emergencies and off-hour assistance, call 1-800-SKY-PAGE
>(759-7243) and enter PIN number 8550070 (primary) or 8550074 (secondary).
>The CIAC Duty Officer, a rotating responsibility, carries the primary
>skypager. The Project Leader carries the secondary skypager.  If you are
>unable to contact CIAC via phone, please use the skypage system.
>
>------------------------------
>This document was prepared as an account of work sponsored by an agency of
>the United States Government.  Neither the United States Government nor the
>University of California nor any of their employees, makes any warranty,
>express or implied, or assumes any legal liability or responsibility for the
>accuracy, completeness, or usefulness of any information, apparatus, product,
>or process disclosed, or represents that its use would not infringe privately
>owned rights.  Reference herein to any specific commercial products, process,
>or service by trade name, trademark, manufacturer, or otherwise, does not
>necessarily constitute or imply its endorsement, recommendation or favoring
>by the United States Government or the University of California.  The views
>and opinions of authors expressed herein do not necessarily state or reflect
>those of the United States Government or the University of California, and
>shall not be used for advertising or product endorsement purposes.
>
>------------------------------
>End of CIAC Notes Number 94-04  94_12_06
>****************************************


From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Newsgroups: bionet.molec-model,bionet.software
Path: biosci!ns1.faseb.org!darwin.sura.net!fconvx.ncifcrf.gov!reming
From: reming@ncifcrf.gov (Mary Remington)
Subject: Palindrome search software
Message-ID: <D0Fxyz.F4D@ncifcrf.gov>
Organization: Frederick Cancer Research and Development Center
References: <3bn8vj$g3u@mercury.interpath.net> <D0F5t9.3w1@arris.com>
Date: Wed, 7 Dec 1994 12:42:33 GMT
Lines: 4
Xref: biosci bionet.molec-model:182 bionet.software:10282


Does anyone know of a software program that will search DNA sequences for
palindromes?   Thanks, Mary


From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!agate!howland.reston.ans.net!pipex!sunsite.doc.ic.ac.uk!lyra.csx.cam.ac.uk!mole.bio.cam.ac.uk!tjrc1
From: tjrc1@mole.bio.cam.ac.uk (Tim Cutts)
Newsgroups: bionet.software
Subject: Re: !!!!Warning: a virus is emailed (fwd)
Date: 7 Dec 1994 12:43:42 GMT
Organization: University of Cambridge, England
Lines: 31
Distribution: bionet
Message-ID: <3c4alu$iru@lyra.csx.cam.ac.uk>
References: <3c414j$l80@mserv1.dl.ac.uk>
NNTP-Posting-Host: mole.bio.cam.ac.uk

Dietmar Tietz <Dietmar.Tietz@agrar.uni-giessen.de> writes:


>>
>> A virus is circulating on the Internet.  If you receive a message with
>> the header "xxx-1" DO NOT READ IT.  Delete immediately or your disk will
>> require treatment by a virus-scanner.  I have had two copies of this
>> message this morning (Sunday) already, but was warned by an early
>> morning phone call from a friend who got hit.
>>
>>************************************************************************

>>>This crossed my virtual desk this afternoon.  Does anyone have more info?
>>>
>>>>>> Somebody is sending e-mail under the title "good times".  If you get
>>>>>anything
>>>>>> like this, DON'T DOWNLOAD THE FILE! ! ! ! ! ! ! ! ! ! It has a
>>virus that
>>>>>> rewrites your hard drive, and you lose anything on your hard
>>drive.  Pleas
>>e
>>>>>> be careful and forward this mail to anyone you care about!

Please could we not have such scare stories?  Such a virus is indeed a
worry, but there's no point in panicking everyone.  Who dies the virus
affact?  PC users?  Mac users?  Unix users?  I find it very hard to
believe that there is any sort of virus that will affect any system
regardless of operating system/mail handler used.  Please be more
specific.

Tim.

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!agate!sunsite.doc.ic.ac.uk!daresbury!not-for-mail
From: Dietmar Tietz <Dietmar.Tietz@agrar.uni-giessen.de>
Newsgroups: bionet.software
Subject: !!!!Warning: a virus is emailed (fwd)
Date: 7 Dec 1994 10:00:51 -0000
Lines: 48
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <3c414j$l80@mserv1.dl.ac.uk>
X-Sender: gh43@hamster.hrz.uni-giessen.de
MIME-Version: 1.0
Original-To: bio-soft@dl.ac.uk


>
> A virus is circulating on the Internet.  If you receive a message with
> the header "xxx-1" DO NOT READ IT.  Delete immediately or your disk will
> require treatment by a virus-scanner.  I have had two copies of this
> message this morning (Sunday) already, but was warned by an early
> morning phone call from a friend who got hit.
>
>************************************************************************

>>This crossed my virtual desk this afternoon.  Does anyone have more info?
>>
>>>>> Somebody is sending e-mail under the title "good times".  If you get
>>>>anything
>>>>> like this, DON'T DOWNLOAD THE FILE! ! ! ! ! ! ! ! ! ! It has a
>virus that
>>>>> rewrites your hard drive, and you lose anything on your hard
>drive.  Pleas
>e
>>>>> be careful and forward this mail to anyone you care about!

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Scott F. Shaffer                        
Eccles Institute of Human Genetics
Bld 533 Rm 6140
University of Utah
SLC, Utah  84112

Internet:  sshaffer@corona.med.utah.edu

(801) 585-5730                  
(801) 585-3599                  

============================================================================
 
******************************************************************
*           Dietmar Tietz, Ph.D.,  Research Scientist            *
*            Biostatistics, Justus-Liebig-University             *
*            Ludwigstr. 27, D-35390 Giessen, Germany             *
*                  Phone: +49-(641)-702-9733                     *
*                   Fax: +49-(641)-702-9724                      *
*              Email: Dietmar.Tietz@Uni-Giessen.de               *
******************************************************************






From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!bloom-beacon.mit.edu!gatech!newsxfer.itd.umich.edu!caen!msunews!harbinger.cc.monash.edu.au!news.cs.su.oz.au!metro!news
From: ginster@magna.com.au
Subject: [wanted] computer dictionaries, biology, ecogoly, zoology...
Message-ID: <D0FBF0.z9@ucc.su.OZ.AU>
Sender: news@ucc.su.OZ.AU
Nntp-Posting-Host: magna.com.au
Organization: Information Services, Sydney University, Sydney, NSW, Australia
Date: Wed, 7 Dec 1994 04:35:23 GMT
Lines: 17

I'm very interested in finding some good dictionaries in a form accessable
from on a computer, which give definitions of the words we would not
usually find in your normal dictionary. These definitions, pertaining
to biological sciences, and even geological sciences would be extreamly
useful to me and my research.

I am even offering to have this kind of thing available on the WWW, but
I need the text. Obviously this is a big request, but instead of starting
from scratch, I wondered if anyone here can help.



 any suggestions would be great. thanks in advance,

Ginny
ginster@magna.com.au


From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!nntp.crl.com!crl8.crl.com!not-for-mail
From: sunger@crl.com (Stefan Unger)
Newsgroups: bionet.molec-model,bionet.software
Subject: Re: modelling on Power Mac?
Followup-To: bionet.molec-model,bionet.software
Date: 6 Dec 1994 21:16:21 -0800
Organization: CRL Dialup Internet Access	(415) 705-6060  [Login: guest]
Lines: 61
Message-ID: <3c3gf5$4u1@crl8.crl.com>
References: <3bn8vj$g3u@mercury.interpath.net> <D0F5t9.3w1@arris.com>
NNTP-Posting-Host: crl8.crl.com
X-Newsreader: TIN [version 1.2 PL2]
Xref: biosci bionet.molec-model:181 bionet.software:10278

There is a new MAC visualization and analysis package called Protein 
Expert that is currently being ported to Power MAC.


e-mail me for more information.  I am the distributor.
Biosoftware Marketing
4151 Middlefield Rd, Ste 109
Palo Alto, CA 94303
415-858-0522
fax: 415-858-0521
sunger@crl.com

current version 680xx with math-coprocessor.  

Justin Diachun 
(diachun@arris.com) wrote:
: In article <3bn8vj$g3u@mercury.interpath.net> morgan@mercury.interpath.net (Morgan Ryan) writes:
: >
: >I just traded up my Mac to a 6100 PowerPC. Nice! But suddenly I have only
: >one working molecular graphics program, RasMol, which has a native PPC
: >version. MolView and MacMolecule are amazingly slow in emulation on the
: >PPC (The PPC has its own math coprocessor, but it doesn't coprocess when
: >emulating 68k...even speedy little MacMolecule takes minutes to come up). 
: >	Do I have any other options? Has anyone ported MolScript to PPC? 
: >Are there any other programs available that I don't know about? (I've 
: >read the faq's and gone to NIH etc. I'm wondering if there is something 
: >newer around that hasn't been inserted in the usual online guides.)
: >	Also, is there a freeware modeller in existence that works like
: >Ball-and-Stick? I'm just a hobbyist--can't afford lots of money for
: >molecular software. What do people put on the well-equipped freeware Mac
: >molecular graphics machine besides RasMol, MolView, MacMolecule and 
: >MacBabel? Anything? Thanks. Morgan Ryan / morgan@mercury.interpath.net

: I have almost the exact same question, and a flyer on a new product.
: Has anyone gotten anything from the Molecular Applications Group?
: They list packages called Look (proteins), SegMod (homology), and
: MacImdad.  The MacImdad product looks interesting.  It claims to have
: a compressed PDB database that can be searched to pull up structures.
: It is also available on PowerPC and other Mac systems.  They offer a
: free demo disk that I have asked for.  The ad reads "Display - Analyze
: - Print" so I guess it is in the RasMol field of applications.  I
: would like to hear how this product compares to anything else on the
: market.

: I have the following contact information on the flyer:
:    Molecular Applications Group
:    445 Sherman Avenue, Suite T
:    Palo Alto, Ca 94306
:    toll free: 1-800-229-7382 (USA only)
:    phone: 415-473-3030
:    fax:  415-473-1795
:    email: info@mag.com

: disclaimer: I have no affiliation with MAG or knowledge of the product.
:             I am simply looking for unbiased 3rd party opinions.

: -- 
: Justin Diachun
: diachun@arris.com
: System Administrator
: Arris Pharmaceutical

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!spool.mu.edu!uwm.edu!lll-winken.llnl.gov!overload.lbl.gov!xpat.postech.ac.kr!news.kreonet.re.kr!sorak.kaist.ac.kr!cojoe
From: cojoe@sorak.kaist.ac.kr (Doo Yeon Kim)
Newsgroups: bionet.software
Subject: Isoelectric point determination program?
Date: 7 Dec 1994 03:30:30 GMT
Organization: Korea Research Environment Open Network (KREONet)
Lines: 12
Message-ID: <3c3a8m$lr4@news.kreonet.re.kr>
NNTP-Posting-Host: sorak.kaist.ac.kr
X-Newsreader: TIN [version 1.2 PL2]

I need software or mail server which predict the isoelectric point from amino 
acid sequence. Please help me.




--

////////Doo Yeon Kim////////




From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!holzwarth3.life.uiuc.edu!user
From: jbuberel@uiuc.edu (Jason L. Buberel)
Newsgroups: bionet.software
Subject: Re: PCR-program for degenerate primers
Date: Tue, 06 Dec 1994 21:17:38 -0600
Organization: Universtiy of Illinois
Lines: 24
Message-ID: <jbuberel-0612942117380001@holzwarth3.life.uiuc.edu>
References: <bolde.1137117697A@news.lu.se>
NNTP-Posting-Host: holzwarth3.life.uiuc.edu

In article <bolde.1137117697A@news.lu.se>, bolde@biogen.wblab.lu.se (Bjšrn
Olde) wrote:

> Where do I find a program that can be used in the design of degenerate
> PCR-primers? I would prefer a macintosh program.
> 
> Bjorn Olde 
> Molecular Neurobiology
> Wallenberg Laboratory
> Sweden

Bjorn,

I have been on the lookout also.  If you find something good (for the
Mac), please let me know.  I will do likewise.

-jason

================
Jason L. Buberel
Graduate Student
Nueroscience Pgm
U of Illinois-UC
================

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Newsgroups: bionet.molec-model,bionet.software
Path: biosci!bloom-beacon.mit.edu!gatech!swrinde!pipex!uunet!arris!diachun
From: diachun@arris.com (Justin Diachun)
Subject: Re: modelling on Power Mac?
Message-ID: <D0F5t9.3w1@arris.com>
Sender: usenet@arris.com
Nntp-Posting-Host: oyster.arris.com
Organization: Arris Pharmaceutical Corp.
References: <3bn8vj$g3u@mercury.interpath.net>
Date: Wed, 7 Dec 1994 02:34:21 GMT
Lines: 45
Xref: biosci bionet.molec-model:180 bionet.software:10275

In article <3bn8vj$g3u@mercury.interpath.net> morgan@mercury.interpath.net (Morgan Ryan) writes:
>
>I just traded up my Mac to a 6100 PowerPC. Nice! But suddenly I have only
>one working molecular graphics program, RasMol, which has a native PPC
>version. MolView and MacMolecule are amazingly slow in emulation on the
>PPC (The PPC has its own math coprocessor, but it doesn't coprocess when
>emulating 68k...even speedy little MacMolecule takes minutes to come up). 
>	Do I have any other options? Has anyone ported MolScript to PPC? 
>Are there any other programs available that I don't know about? (I've 
>read the faq's and gone to NIH etc. I'm wondering if there is something 
>newer around that hasn't been inserted in the usual online guides.)
>	Also, is there a freeware modeller in existence that works like
>Ball-and-Stick? I'm just a hobbyist--can't afford lots of money for
>molecular software. What do people put on the well-equipped freeware Mac
>molecular graphics machine besides RasMol, MolView, MacMolecule and 
>MacBabel? Anything? Thanks. Morgan Ryan / morgan@mercury.interpath.net

I have almost the exact same question, and a flyer on a new product.
Has anyone gotten anything from the Molecular Applications Group?
They list packages called Look (proteins), SegMod (homology), and
MacImdad.  The MacImdad product looks interesting.  It claims to have
a compressed PDB database that can be searched to pull up structures.
It is also available on PowerPC and other Mac systems.  They offer a
free demo disk that I have asked for.  The ad reads "Display - Analyze
- Print" so I guess it is in the RasMol field of applications.  I
would like to hear how this product compares to anything else on the
market.

I have the following contact information on the flyer:
   Molecular Applications Group
   445 Sherman Avenue, Suite T
   Palo Alto, Ca 94306
   toll free: 1-800-229-7382 (USA only)
   phone: 415-473-3030
   fax:  415-473-1795
   email: info@mag.com

disclaimer: I have no affiliation with MAG or knowledge of the product.
            I am simply looking for unbiased 3rd party opinions.

-- 
Justin Diachun
diachun@arris.com
System Administrator
Arris Pharmaceutical

From owner-software@net.bio.net Tue Dec 06 22:00:00 1994
Path: biosci!MAILGATE.GLAXO.COM!agostino~mj%a1.usa.umc
From: agostino~mj%a1.usa.umc@MAILGATE.GLAXO.COM ("Mike Agostino")
Newsgroups: bionet.software
Subject: how many receptors are there?
Date: 7 Dec 1994 05:22:32 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 27
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <54122170214991.326948@USA>
NNTP-Posting-Host: net.bio.net

[This message is converted from WPS-PLUS to ASCII]

There have been a lot of numbers kicked around, based on various
techniques for estimating gene frequencies, that put the total
number of G-protein coupled receptors encoded by the human genome
at anywhere from a couple of hundred to several thousand.

Does anyone out there in Netland have what they are comfortable
with as a number for GPCR's?  Or, do you have any idea where some
of these estimates came from?  If so, could you post or email me
with it and please include where the estimate came from and how
it was derived (no astrology, please).  I realize that all of
these estimates have an element of fantasy to them, so I promise
not to publish or otherwise attribute an estimate to you unless
you beg appropriately.

It would probably be most useful to break it down into total and
non-odorant/sensory receptors.


I will post back to the net a summary of replies (with names
omitted unless otherwise requested).

Thanks,

Rich Buckholz
RGB12955@glaxo.com

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!rutgers!gatech!newsxfer.itd.umich.edu!nntp.cs.ubc.ca!news.bc.net!vanbc.wimsey.com!unixg.ubc.ca!not-for-mail
From: mcclean@flair.law.ubc.ca (John McClean)
Newsgroups: bionet.software
Subject: Re: "Good Times" e-mail virus is a HOAX
Date: 8 Dec 1994 00:08:30 GMT
Organization: UBC FLAIR Project
Lines: 17
Message-ID: <3c5ipu$j1i@nntp.ucs.ubc.ca>
References: <nef-0712941750460001@moose.bioc.cam.ac.uk>
NNTP-Posting-Host: malik.law.ubc.ca
X-Newsreader: WinVN 0.92.1

In article <nef-0712941750460001@moose.bioc.cam.ac.uk>, nef@mole.bio.cam.ac.uk (Nick Fisher) says:
>
>
>The so-called "Good Times" e-mail virus is a HOAX. It is IMPOSSIBLE for a
>text file to infect your computer. Only executable files can carry
>"active" virus code. 

Yes and No. There was I recall some years ago a 'text' file which if sent
to the 'stdout' device of a PC using the DOS command TYPE, would cause some
sort of havoc. This was because the file really had escape sequences which
were sent to the display driver (i.e., if you looked at the file using a 
text editor it would look like rubbish). Granted, this is not really what
you are referring to, and in any event is not really a virus as it cannot
self-replicate.

John McClean


From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!GN.APC.ORG!infomed!ICT.SLD.CU!FRANZ
From: infomed!ICT.SLD.CU!FRANZ@GN.APC.ORG
Newsgroups: bionet.software
Subject: (none)
Date: 7 Dec 1994 21:29:43 -0800
Organization: Centro de Inmunologia Molecular
Lines: 2
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <9412071815.AA14426@infomed>
NNTP-Posting-Host: net.bio.net

subscribe


From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!rutgers!gatech!howland.reston.ans.net!news.moneng.mei.com!uwm.edu!lll-winken.llnl.gov!enews.sgi.com!decwrl!tribune.usask.ca!quartz.ucs.ualberta.ca!gpu!slyseng
From: slyseng@gpu.srv.ualberta.ca (Susan Lyseng)
Newsgroups: bionet.software
Subject: Sequence Analysis Program for PC
Date: 8 Dec 1994 00:59:17 GMT
Organization: University of Alberta
Lines: 15
Message-ID: <3c5lp5$6f0@quartz.ucs.ualberta.ca>
NNTP-Posting-Host: gpu3.srv.ualberta.ca
X-Newsreader: TIN [version 1.2 PL2]

Hello!

I'm looking for a PC compatable program that can do simple sequence analysis 
(restriction enzymes, ORF's, translation etc.).  I've used Strider on the 
Mac and it was adequate for what I want to use it for--but I would really 
like a program for my PC (preferably Windows compatable!).  Does anyone 
know of a ftp site that might have something like this?  (I tried 
ftp.bio.indiana.edu but really had no clue what many of the programs were 
about, the readme files weren't that detailed.....)

Many thanks,

Susan Lyseng
University of Alberta
Canada

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!rutgers!csn!yuma!purdue!mozo.cc.purdue.edu!darwin2.bio.purdue.edu!user
From: flip@bogie2.bio.purdue.edu (Phillip D. Russell)
Newsgroups: bionet.molec-model,bionet.software
Subject: Re: modelling on Power Mac?
Date: Wed, 07 Dec 1994 18:59:24 -0600
Organization: Purdue University
Lines: 39
Message-ID: <flip-0712941859240001@darwin2.bio.purdue.edu>
References: <3bn8vj$g3u@mercury.interpath.net> <D0F5t9.3w1@arris.com>
NNTP-Posting-Host: darwin2.bio.purdue.edu
Xref: biosci bionet.molec-model:184 bionet.software:10293

In article <D0F5t9.3w1@arris.com>, diachun@arris.com (Justin Diachun) wrote:

> In article <3bn8vj$g3u@mercury.interpath.net>
morgan@mercury.interpath.net (Morgan Ryan) writes:
> >
> >I just traded up my Mac to a 6100 PowerPC. Nice! But suddenly I have only
> >one working molecular graphics program, RasMol, which has a native PPC
> >version. MolView and MacMolecule are amazingly slow in emulation on the
> >PPC (The PPC has its own math coprocessor, but it doesn't coprocess when
> >emulating 68k...even speedy little MacMolecule takes minutes to come up). 
> >       Do I have any other options? Has anyone ported MolScript to PPC? 
> >Are there any other programs available that I don't know about? (I've 
> >read the faq's and gone to NIH etc. I'm wondering if there is something 
> >newer around that hasn't been inserted in the usual online guides.)

> I have almost the exact same question, and a flyer on a new product.
> Has anyone gotten anything from the Molecular Applications Group?
> They list packages called Look (proteins), SegMod (homology), and
> MacImdad.  The MacImdad product looks interesting.  It claims to have
> a compressed PDB database that can be searched to pull up structures.
> It is also available on PowerPC and other Mac systems.  They offer a
> free demo disk that I have asked for.  The ad reads "Display - Analyze
> - Print" so I guess it is in the RasMol field of applications.  I
> would like to hear how this product compares to anything else on the
> market.

We have a FREE program that runs native on the PowerMac and
blows the commercial programs away.

It's called MolView and you can get it from:
http://www.bio.purdue.edu/MolView/MolView.html

Flip

-- 
         __@    Phillip "Flip" Russell  | Purdue University      __@
  _ -_,_-\<,_flip@bogie2.bio.purdue.edu | West Lafayette, IN  _ -\<,_
 (_)-----/-(_)           The important things...             (_)-/-(_)
                        My bikes and my Macintosh

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Newsgroups: bionet.software
Path: biosci!daresbury!sunsite.doc.ic.ac.uk!lyra.csx.cam.ac.uk!pipex!demon!visigoth.demon.co.uk!user
From: pettsj@visigoth.demon.co.uk (James Petts)
Subject: Free/shareware NMR processing s/w
Message-ID: <pettsj-0812940425590001@visigoth.demon.co.uk>
Sender: news@demon.co.uk (Usenet Administration)
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Date: Thu, 8 Dec 1994 04:25:59 GMT
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Does anybody know of free or shareware NMR processing s/w (for any m/c)?

-- 
=== James Petts ===
In the world of CD-ROM, a horse will always be an herbivorous quadruped, and there'll be endless examples to prove just that. But that world will never tell you how it feels to ride a horse.
Or fall off it.

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!daresbury!trane.uninett.no!sunic!pipex!howland.reston.ans.net!gatech!bloom-beacon.mit.edu!news.bu.edu!usenet
From: cohen@med-card01.bu.edu (Jeffrey Cohen)
Newsgroups: bionet.software
Subject: NIH Image Macros for Cardiac Function Measurements
Date: 8 Dec 1994 16:19:48 GMT
Organization: Boston University
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     I am looking for Macros to run on the Macintosh-based NIH Image
software.  I'd like to make measurements of left ventricular wall
motion using Sheehan's centerline method.  In addition, I want to
measure LV volumes using Simpson's formula.  If anyone has information
about these Macros or any Macintosh-based programs to perform these
measurements, please contact me at  cohen@med-card01.bu.edu   If this
is the wrong place to post this message, please let me know.  Thanks. 
Jeffrey Cohen

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Newsgroups: bionet.general,bionet.software
Path: biosci!daresbury!sunsite.doc.ic.ac.uk!pipex!uknet!festival!castle.ed.ac.uk!proberts
From: proberts@castle.ed.ac.uk (P Roberts)
Subject: Plasmid drawing programs
Message-ID: <D0HLsK.Kpu@festival.ed.ac.uk>
Sender: news@festival.ed.ac.uk (remote news read deamon)
Organization: Edinburgh University
Date: Thu, 8 Dec 1994 10:14:43 GMT
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Xref: biosci bionet.general:12364 bionet.software:10301

Greetings,
          Please could someone recommend some plasmid drawing packages
for the PC.  They need to run on a 486 platform.

Thanks, in advance,
                       Paul


From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!daresbury!bioftp.unibas.ch!citi2.fr!jussieu.fr!oleane!pipex!swrinde!howland.reston.ans.net!quagga.ru.ac.za!ucthpx!itu1.sun.ac.za!k4027.mikro.sun.ac.za!9050175
From: 9050175@MATIES.SUN.AC.ZA (M GAGIANO )
Newsgroups: bionet.software
Subject: Help wanted on www and mosaic
Date: Thu, 8 Dec 1994 05:51:45 GMT
Organization: University of Stellenbosch, South Africa
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Message-ID: <9050175.5.786865905@MATIES.SUN.AC.ZA>
NNTP-Posting-Host: 146.232.84.17
Summary: Help wanted on www and mosaic
Keywords: www and mosaic

Could somebody please help.  I want to aquire the software to access the 
Internet via Windows as well as e-mail and FTP through Windows.  Where would 
I find this software and how would I go on about installing it.  Please 
refer me to a FTP site where I could download this programmes from or get 
the necessary information from or send it to the following e-mail adresses:

9050175@maties.sun.ac.za
9050175@sunvax.ac.za

Any help will be greatly appreciated.

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!CS.Arizona.EDU!news.Arizona.EDU!hamblin.math.byu.edu!sol.ctr.columbia.edu!spool.mu.edu!uwm.edu!psuvax1!news.cc.swarthmore.edu!mac04.parrishd.swarthmore.edu!user
From: ehom1@cc.swarthmore.edu (Erik Forbes Y. Hom '95)
Newsgroups: bionet.software
Subject: Q: searching for phosphorylation sites
Followup-To: bionet.software
Date: Thu, 08 Dec 1994 00:17:14 +0000
Organization: Laboratory of Neurobiology, Swarthmore College
Lines: 7
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Hi netters, Could anyone here tell the best way to search for potential
phosphorylation sites or sequence homologies to phosphorylated regions. 
Are there programs that do this for you?  What would be the best way to
proceed?
Thanks in advanced for your help!

erik

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!CS.Arizona.EDU!news.Arizona.EDU!hamblin.math.byu.edu!sol.ctr.columbia.edu!howland.reston.ans.net!vixen.cso.uiuc.edu!uxa.cso.uiuc.edu!dalke
From: dalke@uxa.cso.uiuc.edu (Andrew Dalke)
Newsgroups: bionet.software
Subject: Re: "Good Times" e-mail virus is a HOAX
Date: 8 Dec 1994 05:37:02 GMT
Organization: University of Illinois at Urbana
Lines: 30
Message-ID: <3c661u$qi@vixen.cso.uiuc.edu>
References: <nef-0712941750460001@moose.bioc.cam.ac.uk> <3c5ipu$j1i@nntp.ucs.ubc.ca>
NNTP-Posting-Host: uxa.cso.uiuc.edu

In <3c5ipu$j1i@nntp.ucs.ubc.ca> John McClean <mcclean@flair.law.ubc.ca>
said:
>    .... This was because the file really had escape sequences which
>were sent to the display driver... Granted, this is not really what
>you are referring to, and in any event is not really a virus as it cannot
>self-replicate.

  You are bringing back the good old days back when I did those kinda
tricks. :) On a DOS machine, if you set DEVICE=ANSI.SYS then the ansi
device driver would be loaded.  This interprets both keypresses and
display output.  You could use it to change the color, location, etc.
of the text, with the appropriate escape sequence - something like
  ESC [ <ansi command>;
Alas, I've forgotten them :(

  Anyway, one of the things you could use this for is to reprogram the
keys so that a keypress would return another character, or even a
string.  For instance, you could reprogram F1 to send the sequence
"HELP<return>", or whatever.

  In principle you could make it do something like map the enter key
to "del *.*<return>".  That would be nasty.  BTW, I can't think of
anyway to make a reproducing an email message in ANSI escape code, so
you don't have to worry about viruses from me.
  (Actually, I'm doing computer simulations of the poliovirus; so you
do have to worry about viruses from me :)

						Andrew
						dalke@uiuc.ede


From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!rutgers!gatech!howland.reston.ans.net!Germany.EU.net!news.dfn.de!scsing.switch.ch!elna.ethz.ch!smac.ethz.ch!user
From: tan@mol.biol.ethz.ch (Song Tan)
Newsgroups: bionet.molec-model,bionet.software
Subject: Re: Palindrome search software
Date: Wed, 07 Dec 1994 19:27:53 +0100
Organization: ETH-Honggerberg (Swiss Federal Institute of Technology)
Lines: 14
Message-ID: <tan-0712941927530001@smac.ethz.ch>
References: <3bn8vj$g3u@mercury.interpath.net> <D0F5t9.3w1@arris.com> <D0Fxyz.F4D@ncifcrf.gov>
NNTP-Posting-Host: smac.ethz.ch
Xref: biosci bionet.molec-model:185 bionet.software:10295

> Does anyone know of a software program that will search DNA sequences for
> palindromes?   Thanks, Mary

Programs that analyze sequences for possible RNA stemloop structures
should do the trick.  STEMLOOP in the GCG package is one example.

Hope this helps.

-- 
Song Tan
Institute for Molecular Biology and Biophysics
ETH-Honggerberg (Swiss Federal Institute of Technology)
8093 Zurich, Switzerland
email:  tan@mol.biol.ethz.ch

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!bloom-beacon.mit.edu!grapevine.lcs.mit.edu!olivea!sgigate.sgi.com!nocusuhs!info.usuhs.mil!NewsWatcher!user
From: MSALMINEN_at_WRAIR__GUDE__1@mail.hjf.org (Mika Salminen)
Newsgroups: bionet.software,bionet.virology
Subject: FastDNAML for the DEC Alpha running VMS?
Date: 8 Dec 1994 19:14:14 GMT
Organization: Henry M. Jackson Foundation
Lines: 10
Message-ID: <MSALMINEN_at_WRAIR__GUDE__1-0812941515550001@131.158.31.163>
NNTP-Posting-Host: 131.158.31.163
Xref: biosci bionet.software:10307 bionet.virology:1242

Hi Netters,

I can't get FastDNAML compiled on our DEC Alpha running VMS. Has anyone
out there been succesful, and if so could they point me to a place for
ftp-ing the binaries?

While I'm at it, has anyone added the program to GDE running on a Sun, and
is that extension+ executables available?

Thanks in advance, Mika Salminen

From owner-software@net.bio.net Wed Dec 07 22:00:00 1994
Path: biosci!daresbury!trane.uninett.no!sunic!pipex!howland.reston.ans.net!nctuccca.edu.tw!aladdin.iii.org.tw!usenet
From: kjhsiao@tpts1.seed.net.