From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in1.uu.net!nwnews.wa.com!nwfocus.wa.com!krel.iea.com!e5.iea.com!user
From: stevem@comtch.iea.com (Steve McGrew)
Newsgroups: bionet.software
Subject: Re: Seeking software for graphing and spreadsheet functions
Date: 2 Feb 1996 14:21:59 GMT
Organization: New Light Industries, Ltd.
Lines: 14
Distribution: world
Message-ID: <stevem-0202960622410001@e5.iea.com>
References: <LCL.96Jan31114205@porky.bu.edu>
NNTP-Posting-Host: e5.iea.com

In article <LCL.96Jan31114205@porky.bu.edu>, lcl@porky.bu.edu (Lisa
Caroline Lewis) wrote:

> The company I work for is looking for software that can both handle
> graphing and spreadsheet functions.  We need to have programming
> ability with it, so that we can write our own macros.  The graphing
> must be able to do sigmoidal plots on a semi-log scale [dose-response
> curves].

Excel for Windows does all the things you want.  In addition, "Generator"
a genetic algorithm software package from New Light Industries, can work
with Excel to do optimizations like curve fitting, model development,
equation solving and lots more.  If you're interested, check the NLI home
page at www.iea.com/~nli.  Or, e-mail at nli@comtch.iea.com.

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.uoregon.edu!news.rediris.es!power.ci.uv.es!usenet
From: jose oviedo <oviedo@uv.es>
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: 2 Feb 1996 18:10:25 GMT
Organization: dep. parasitology-university of valencia (spain)
Lines: 12
Message-ID: <4etk2h$tbo@power.ci.uv.es>
References: <jlepine-0202961003280001@s219.haverford.edu>
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To: jlepine@haverford.edu
X-URL: news:jlepine-0202961003280001@s219.haverford.edu

To: jlepine@haverford.edu

You can obtained mac software in

iluso.uv.es

Jose A. Oviedo
Parasitology
University of Valencia
Spain



From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!COMPUSERVE.COM!76773.1171
From: 76773.1171@COMPUSERVE.COM (gus  baydoun)
Newsgroups: bionet.software
Subject: joining group
Date: 1 Feb 1996 19:08:33 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 5
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <960202025732_76773.1171_EHT158-1@CompuServe.COM>
NNTP-Posting-Host: net.bio.net

	Could you send me information about your group.I am an independent
software developer interested in this area of software.
	Ghassan Baydoun.
	Compuserve:76773,1171


From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!daresbury!bioftp.unibas.ch!infobiogen.fr!pasteur.fr!univ-lyon1.fr!in2p3.fr!swidir.switch.ch!scsing.switch.ch!news.rediris.es!power.ci.uv.es!usenet
From: jose oviedo <oviedo@uv.es>
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: 2 Feb 1996 17:40:41 GMT
Organization: dep. parasitology-university of valencia (spain)
Lines: 10
Message-ID: <4etiap$tbo@power.ci.uv.es>
References: <jlepine-0202961003280001@s219.haverford.edu>
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To: jlepine@haverford.edu
X-URL: news:jlepine-0202961003280001@s219.haverford.edu

You can obtained mac software in

iluso.uv.es

Jose A. Oviedo
Parasitology
University of Valencia
Spain



From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!daresbury!bioftp.unibas.ch!infobiogen.fr!pasteur.fr!univ-lyon1.fr!in2p3.fr!swidir.switch.ch!scsing.switch.ch!news.rediris.es!power.ci.uv.es!usenet
From: jose oviedo <oviedo@uv.es>
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: 2 Feb 1996 17:41:14 GMT
Organization: dep. parasitology-university of valencia (spain)
Lines: 10
Message-ID: <4etibq$tbo@power.ci.uv.es>
References: <jlepine-0202961003280001@s219.haverford.edu>
NNTP-Posting-Host: parasit.parasit.uv.es
Mime-Version: 1.0
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Content-Transfer-Encoding: 7bit
X-Mailer: Mozilla 1.12(Macintosh; I; 68K)
To: jlepine@haverford.edu
X-URL: news:jlepine-0202961003280001@s219.haverford.edu

You can obtained mac software in

iluso.uv.es

Jose A. Oviedo
Parasitology
University of Valencia
Spain



From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!EU.net!sun4nl!uva.nl!amc!ka2-05.amc.uva.nl!user
From: a337ard@horus.sara.nl (ard jonker)
Newsgroups: bionet.software
Subject: Re: Image analysis software?
Date: Fri, 02 Feb 1996 09:52:06 +0100
Organization: University of Amsterdam (fac. med.)
Lines: 21
Message-ID: <a337ard-0202960952060001@ka2-05.amc.uva.nl>
References: <4eoiml$197@gwsun.medinf.mu-luebeck.de>
NNTP-Posting-Host: ka2-05.amc.uva.nl

In article <4eoiml$197@gwsun.medinf.mu-luebeck.de>, "Oliver Schmitt"
<schmitt@gwsun.medinf.mu-luebeck.de> wrote:

> KONTRON in germany (KS System).
> KHOROS (free).
> >I would like to know if there is any image analysis software available
> >for measuring fruit and vegetable shapes. 
> 
> Optimas Corporation's OPTIMAS image analysis software includes several
> measurements for quantifying shape and texture.  If you will e-mail me
> with you physical mailing address (number, street, city, state, zip, etc.)
> I will send you a brochure and demonstration disk for OPTIMAS.
> 
> Best regards,
> 
> Matt Davidson
> Sales Manager USA/Canada
> Optimas Corporation

NIH-Image free ftp-able from zippy.nimh.nih.gov for macintosh. about 1 MB
ard

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!lhc.nlm.nih.gov!gold!epstein
From: epstein@gold.nlm.nih.gov (Jonathan Epstein)
Newsgroups: bionet.software
Subject: Re: [Q]:?how to run MAC SW on PC (Windows95)
Date: 2 Feb 1996 16:08:28 GMT
Organization: National Library of Medicine
Lines: 21
Message-ID: <4etcts$a25@lhc.nlm.nih.gov>
References: <4eprqm$kes@mserv1.dl.ac.uk> <31114385.41C6@rhapsody.stanford.edu>
NNTP-Posting-Host: 130.14.25.47
X-Newsreader: TIN [version 1.2 PL2]

Lionel Gilet (gilet@rhapsody.stanford.edu) wrote:
> In article <4eprqm$kes@mserv1.dl.ac.uk>, Ivo Wiesner  <nfix@jcu.cz> wrote:
> >
> >Hello Netters out there!
> >
> >Could anybody inform me:
> >
> >1. if there is any emulator for PC (Windows) platform
> >which enables running MAC software?

See comp.emulators.mac.executor.  Good luck ... it doesn't look like a very
comprehensive solution, but I believe that it's the best one out there.

- Jonathan


Jonathan Epstein                                epstein@ncbi.nlm.nih.gov
National Center for Biotechnology Information   Phone: (301)496-2477 x254
National Library of Medicine                    Building 38A, Room 8N805
National Institutes of Health                   8600 Rockville Pike
						Bethesda, MD 20894

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!newsxfer2.itd.umich.edu!newsxfer.itd.umich.edu!news.flint.umich.edu!news.gmi.edu!msunews!netnews.upenn.edu!news.cc.swarthmore.edu!news.haverford.edu!s219.haverford.edu!user
From: jlepine@haverford.edu
Newsgroups: bionet.software
Subject: want mac software sites
Date: Fri, 02 Feb 1996 10:03:28 -0500
Organization: Bryn Mawr and Haverford College NetNews
Lines: 3
Message-ID: <jlepine-0202961003280001@s219.haverford.edu>
NNTP-Posting-Host: 165.82.1.219
X-Newsreader: Value-Added NewsWatcher 2.0b22.0+

I really need a www site where I can download MACINTOSH software.
Everything I try to download turns out to be for other systems.
jlepine@haverford.edu

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!usenet.eel.ufl.edu!news.ultranet.com!bigboote.WPI.EDU!news3.near.net!yale!news.ycc.yale.edu!news
From: Danny Chamovitz <chamo>
Newsgroups: bionet.software
Subject: boxshade or similar
Date: 2 Feb 1996 18:21:48 GMT
Organization: Yale University
Lines: 25
Message-ID: <4etkns$n7g@news.ycc.yale.edu>
NNTP-Posting-Host: peaplant.biology.yale.edu
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Does anyone know of a BOXSHADE type of program for Mac or UNIX?  BOXSHADE is a
freeware that foramts alignments with black and grey boxes showing sequence
conservation.

Thank

Danny
chamo@peaplant.biology.yale.edu
________________________________________________________________________________

Daniel Chamovitz	      tel: 203-432-8909
Department of Biology	      fax: 203-432-3854
Yale University
http://peaplant.biology.yale.edu:8001/denglab.html
P.O.Box 208104		      home tel: 203-776-3474
New Haven, CT 06520-8104


"Let's not keep silent. Let our voices rise high to speak of our commitment to 
peace for all times to come, and let us tell those who live in darkness who are 
the enemies of life ... we are not ashamed, nor are we afraid, nor are we
anything but determined to fulfill the legacy for which my friend fell..."

King Hussein of Jordan, November 7, 1995


From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!EU.net!sun4nl!uva.nl!amc!ka2-05.amc.uva.nl!user
From: a337ard@horus.sara.nl (ard jonker)
Newsgroups: bionet.software
Subject: Re: [Q]:?how to run MAC SW on PC (Windows95)
Date: Fri, 02 Feb 1996 14:04:31 +0100
Organization: University of Amsterdam (fac. med.)
Lines: 26
Message-ID: <a337ard-0202961404310001@ka2-05.amc.uva.nl>
References: <4eprqm$kes@mserv1.dl.ac.uk> <31114385.41C6@rhapsody.stanford.edu>
NNTP-Posting-Host: ka2-05.amc.uva.nl

In article <31114385.41C6@rhapsody.stanford.edu>, Lionel Gilet
<gilet@rhapsody.stanford.edu> wrote:

> In article <4eprqm$kes@mserv1.dl.ac.uk>, Ivo Wiesner  <nfix@jcu.cz> wrote:
> >Could anybody inform me:
> >1. if there is any emulator for PC (Windows) platform
> >which enables running MAC software?
> >2.how difficult work represents to rewrite Mac software for Windows PC?
> I have no idea concerning the first point.
...
You can run Executor, demo ftp-able from ARDI. Basically, it resembles the
speed of a Mac II under system 6 when used on a 66MHz 486. So you turn
your PC into a '86 Mac. Don't ask me on how to set it up, I have no PC
experience other than have tested Executor once ;-) It might do some jobs.
Have a look from the other side (ie. the other way around, softwindows on
a PPC runs a bit faster yet giving access to both platforms
simultaneously)

> As far as rewriting a Mac software for Windows PC, it really depends
> on the language used, the size of the program and what it does.

If I understand its docs correctly, the MetroWerks Code Warrior compiler
is cross platform; you can develop both Windoze and Macintosh programs on
a mac with the same compiler, which compiles Pascal, C and C++.

ard

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!usenet.ucs.indiana.edu!sunflower.bio.indiana.edu!gilbertd
From: gilbertd@sunflower.bio.indiana.edu (Don Gilbert)
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: 2 Feb 1996 21:52:08 GMT
Organization: Biology, Indiana University - Bloomington
Lines: 8
Message-ID: <4eu128$q56@usenet.ucs.indiana.edu>
References: <jlepine-0202961003280001@s219.haverford.edu>
NNTP-Posting-Host: sunflower.bio.indiana.edu

for molecular and other biology free/shareware for Macintoshes,
take a look at IUBio archive, at iubio.bio.indiana.edu, using
ftp, gopher, http internet protocols (e.g., http://iubio.bio.indiana.edu/ )
In the Software+Data section, look in folder molbio/mac/, or
folder biology/mac/ .

-- 
-- d.gilbert--biocomputing--indiana u--bloomington--gilbertd@bio.indiana.edu

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!nntp.crl.com!a104024.sfo4.as.crl.com!user
From: sunger@a.crl.com (Stefan Unger)
Newsgroups: bionet.software
Subject: Re: Primer design software
Date: 2 Feb 1996 17:16:48 GMT
Organization: BioSoftware Marketing
Lines: 22
Message-ID: <sunger-0202960919320001@a104024.sfo4.as.crl.com>
References: <4eqnlg$j3f@news.ycc.yale.edu>
NNTP-Posting-Host: a104024.sfo4.as.crl.com

RightPrimer is a useful program.  You can read about it and others
at the BIO Online Store at www.bio.com.  Hope this helps.


In article <4eqnlg$j3f@news.ycc.yale.edu>, gary.rudnick@yale.edu (Gary
Rudnick) wrote:

> Does anyone know of a reasonably priced alternative to Oligo for
> PC-based primer design.  We have both Gene Runner and Primer Designer
> and they both leave something to be desired, but Oligo is so
> expensive.  Any ideas?
> 
> Gary Rudnick
> rudnick@biomed.med.yale.edu

-- 
Stefan Unger, Ph.D.                                  
BioSoftware Marketing
4151 Middlefield Rd, Ste 109
Palo Alto, CA 94303-4743
Full technical software marketing services; 
Product Manager, Scientific Software, Bio Online Store at www.bio.com

From owner-software@net.bio.net Thu Feb 01 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!EU.net!sun4nl!sci.kun.nl!usenet
From: Friso Westerhuis <westerhuis@nici.kun.nl>
Newsgroups: bionet.software
Subject: Re: EEG (brainwave) analysis
Date: 2 Feb 1996 13:09:04 GMT
Organization: University of Nijmegen, The Netherlands
Lines: 11
Message-ID: <4et2dg$nui@wn1.sci.kun.nl>
References: <30FF00A4.7E6D@biosys.zynet.co.uk> <4dvhgv$26ts@hopper.acs.ryerson.ca>
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A very good system is the new ACODAS system for Windows it contains
software to display the signal online and offline
a sofware development libary 
an AD conversion board (sorry for my English)
all kinds of analysis methods like FFT etc.


Friso




From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
Path: biosci!biosci!not-for-mail
From: "David J. States" <states@ibc.wustl.edu>
Newsgroups: bionet.general,comp.theory,comp.databases,comp.graphics,bionet.software,bionet.biophysics,,comp.ai,sci.bio.technology,sci.engr.biomed,wu.general
Subject: CFP and extended deadline - Intelligent Systems for Molecular Biology '96 Conference
Date: 2 Feb 1996 19:28:26 -0800
Organization: Institute for Biomedical Computing
Lines: 102
Sender: daemon@net.bio.net
Distribution: world
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Xref: biosci bionet.general:19719 comp.theory:9049 comp.databases:33501 bionet.software:14616 bionet.biophysics:1669 comp.ai:21862 sci.bio.technology:4701 sci.engr.biomed:5390

The Fourth International Conference on Computational Biology
         Intelligent Systems for Molecular Biology '96
                         June 12-15, 1996
       Washington University, St. Louis, Missouri, USA

                 http://ibc.wustl.edu/ismb96

                        Call For Papers

An electronic mailing list can be joined by sending a message to
ismb96@ibc.wustl.edu with the word "subscribe" as the body of the
message.

                          Key Dates

Meeting:                June 12-15, 1996
Paper Submissions
  Papers due:           Feb 6, 1996  *** note extended date ***
  Replies to authors:   Mar 15, 1996
  Revised papers due:   Apr 1, 1996
Open Poster Submissions
  Abstracts due:        Apr 1, 1996
Tutorial Proposals
  Full proposals due:   March 18, 1996
  Replies to authors:   April 1, 1996
  Draft handouts due:   April 15, 1996
  Final handouts due:   May 13, 1996
  Tutorials presented:  June 12, 1996

The purpose of the ISMB conference is to disseminate the latest
developments in computational molecular biology and biophysics and to
stimulate new work on the application of intelligent computational
systems to problems in molecular biology. ISMB is a multidisciplinary
conference bringing together scientists from computer science,
mathematics, statistics, and molecular biology.  Its scope extends to
any computational method or system supporting a biological task that
is algorithmically, cognitively, or conceptually challenging, involves
a synthesis of heterogeneous information, or exhibits the emergent
properties of an "intelligent system." From a computational
perspective, areas of interest include adaptive systems, intelligent
experimental control, data modeling, machine learning, artificial
intelligence, combinatorics, stochastic optimization, string and graph
algorithms, linguistic methods, and parallel computer
technologies. Biological areas of interest include molecular
structure, genomics, molecular sequence analysis, evolution and
phylogenetics, adaptive experimental systems, and molecular
biology. Emphasis is placed on the validation of methods using real
data sets and on practical application in the biological sciences.

The ISMB conference has attracted a large and enthusiastic audience
comprising scientists involved in application areas such as artificial
intelligence, structural biology, DNA, RNA and protein sequence
analysis and structure prediction, genome mapping, gene
identification, molecular biology data and knowledge bases, and the
modeling of biochemical processes. We are continuing the tradition of
soliciting original papers, which will be rigorously refereed and
published (by AAAI Press and the MIT Press) in proceedings available
at the conference. The conference proceedings are indexed in the
Medline database. The previous ISMB meetings were

  1993: National Library of Medicine, USA
  1994: Stanford University, USA
  1995: Cambridge University, UK

The four-day conference will feature introductory and advanced
tutorials on June 12th and presentations of original refereed papers,
posters, and invited talks (June 13-15).

There will be special sessions at the conference on "Whole Genomes:
Challenges and Implications," and on the "Interconnection of Molecular
Biology Databases (MIMBD)." A test suite of raw data will be set aside
to evaluate base-calling and gene-finding programs. A job fair and a
vendor fair are also being organized.

Organizing committee
  David States (states@ibc.wustl.edu)
  Terry Gaasterland (gaasterl@mcs.anl.gov)
  Randall Smith (rsmith@imgen.bcm.tmc.edu)

Keynote Speakers
  Robert Waterston, Washington Univ., St. Louis
  David Haussler, Univ. of California, Santa Cruz
  Russell Doolittle, Univ. of California, San Diego
  Chris Sander, EMBL, Heidelberg

Contact address
ISMB '96
Institute for Biomedical Computing
Washington University
700 South Euclid Avenue
St. Louis, MO  63110-1012
USA
Phone: (314) 362-2134
FAX:   (314) 362-0234


-- 
David J. States
Institute for Biomedical Computing / Washington University in St. Louis




From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.bctel.net!kryten.awinc.com!uucp105!bryan.webster
From: bryan.webster@pcc.awinc.com (Bryan Webster)
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: Sat,  3 Feb 1996 07:28:45 GMT
Message-ID: <96020308175880@pcc.awinc.com>
Organization: Peace Country Computers
Distribution: world
References: <jlepine-0202961003280001@s219.haverford.edu>
Lines: 8         

-> From: jlepine@haverford.edu
-> Subject: want mac software sites
->
-> I really need a www site where I can download MACINTOSH software.
-> Everything I try to download turns out to be for other systems.
-> jlepine@haverford.edu
When you are on the www next, try using one of the search systems
such as YAHOO to locate sites with MAC software.

From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
Newsgroups: bionet.software
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!nntp.coast.net!harbinger.cc.monash.edu.au!news.cs.su.oz.au!tmx!news.tmx.com.au!news
From: pajell@midcoast.com.au
Subject: software to predict lake stratification
Message-ID: <DM6Fvr.2Fv@online.tmx.com.au>
Nntp-Posting-Host: pajell.midcoast.com.au
Sender: news@online.tmx.com.au (System Administrator)
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Date: Sat, 3 Feb 1996 19:53:37 GMT
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Lines: 8

Does anyone know of a reasonably simple model for predicting the
behaviour of the thermocline (ie lake stratification) in impounded
freshwaters?  I am studying the potential for a proposed manmade lake
system to stratify and turnover.
Peter Jelliffie
4 Gordon St Coffs Harbour NSW 2450 Australia
e-mail pajell@midcoast.com.au


From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
Path: biosci!angis.su.OZ.AU!tim
From: tim@angis.su.OZ.AU (Tim Littlejohn)
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: 3 Feb 1996 03:30:11 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 21
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <Pine.SOL.3.91.960203222552.17204E-100000@morgan.angis.su.OZ.AU>
References: <4eu128$q56@usenet.ucs.indiana.edu>
NNTP-Posting-Host: net.bio.net

On 2 Feb 1996, Don Gilbert wrote:

> for molecular and other biology free/shareware for Macintoshes,
> take a look at IUBio archive, at iubio.bio.indiana.edu, using
> ftp, gopher, http internet protocols (e.g., http://iubio.bio.indiana.edu/ )
> In the Software+Data section, look in folder molbio/mac/, or
> folder biology/mac/ .

And for those of you in Australia or close by in net terms, have a look 
at the ANGIS archive at:

    ftp://www.angis.su.oz.au/pub/mac/

Tim Littlejohn

--------------------------------------------------------------------------
|   ANGIS- The Australian National Genomic Information Service           |
|                     http://www.angis.su.oz.au                          |
|      email: tim@angis.su.oz.au    Phone/FAX: 61-2-351 2948             |
--------------------------------------------------------------------------


From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!sierra.net!bigchief-d15
From: drr@sierra.net (Denis Renard)
Newsgroups: bionet.software
Subject: Re: want mac software sites
Date: Sat, 03 Feb 96 04:09:21 GMT
Organization: Sierra-Net
Lines: 15
Message-ID: <4eun5h$fn8_001@bigchief-d15.sierra.net>
References: <jlepine-0202961003280001@s219.haverford.edu>
NNTP-Posting-Host: bigchief-d15.sierra.net
X-Newsreader: News Xpress Version 1.0 Beta #4

In article <jlepine-0202961003280001@s219.haverford.edu>,
   jlepine@haverford.edu wrote:
>I really need a www site where I can download MACINTOSH software.
>Everything I try to download turns out to be for other systems.
>jlepine@haverford.edu

My main entry point for Mac stuff is:
http://macfaq.com

For an all purpose site (you can select Mac only):
http://www.shareware.com (aka CNet Virtual Software Library)	

I'm not sure that they have much Biology programs but Biology is not my forte.

Hope this helps, Denis

From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
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From: dkim@nmsu.edu (DANIEL Y KIM)
Newsgroups: bionet.software
Subject: MOLSCRIPT compiled for MSDOS or WINDOWS?
Date: 31 Jan 1996 18:55:52 GMT
Organization: New Mexico State University, Las Cruces, NM
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Hello:

I am looking for a compiled .EXE of MOLSCRIPT that can run in DOS or 
WINDOWS.  Does anyone have such a thing?  Per Kraulis states that he has 
heard of such ports, but has no details.

Thank you.

Daniel Kim
dkim@nmsu.edu

From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
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From: jnthnrks@dordt.edu (Jonathan Eerkes)
Newsgroups: bionet.software
Subject: Re: Biology Education Software FAQ
Date: 3 Feb 1996 19:26:00 GMT
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: http://www.zoology.washington.edu/biosoft/

: Hope that's useful to some of you.

: Eli Meir
: Dept of Zoology, Univ of Washington
: meir@zoology.washington.edu


Thanks!  I've been looking at this topic for a while now, since I am
doing an Individual Studies trying to write some educational software
in Visual Basic (it's the only language I know).

Is there any other good sites/sources I could use to find out what
type of programs are out there?  I don't want to write a program thats
been done a billion times before.

--
If your parents didn't have any children,
There is a good chance you won't have any.

                                                  Jonathan Eerkes
                                             (jnthnrks@cc.dordt.edu)      


From owner-software@net.bio.net Fri Feb 02 22:00:00 1996
Path: biosci!PCLSP2.KUICR.KYOTO-U.AC.JP!kissy
From: kissy@PCLSP2.KUICR.KYOTO-U.AC.JP (kissy)
Newsgroups: bionet.software
Subject: (no subject)
Date: 3 Feb 1996 04:50:02 -0800
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Hello, my friends!!

I am losing my time to find the PDBViewer.
Please tell me how to get it.

Sincerely yours.







From owner-software@net.bio.net Sat Feb 03 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!tank.news.pipex.net!pipex!demon!asheep.demon.co.uk
From: Robert@Asheep.Demon.CO.Uk (Robert Shell)
Newsgroups: bionet.software
Subject: Re: Structure conversion software
Date: Sun, 04 Feb 1996 23:09:44 GMT
Lines: 44
Message-ID: <823476203.7787@asheep.demon.co.uk>
References: <4eknof$635@netserver.univ-lille1.fr>
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philippe@ICPL2.UNIV-LILLE2.FR (Philippe CHAVATTE) wrote:

>>I look for a software which can convert structures 2D or 3D in SMILES chemical
>>notation line.

There are a large number of methods for handling the convertion of between 1D line
notations like SMILES , 2D depictions for papers and documents and 3D molecular
configurations for modelling and property calculations. One of the best source of
these utilitiies is the Daylight with their Programming tool-kits and applications.

For quick creation of 3D configurations for 3D chemical database searching and
starting points for MOPAC and other calculations are are a number of commerical tools
:-

Concord 	Tripos USA 
Rubicon 	Daylight see http://www.daylight.com
Chem-X		Chemical Design limited UK

CACTVS               see http://schiele.organik.uni-erlangen.de/cactvs
		(free convertion service for a small number of structures via the WWW)

There creation of smiles codes from 2D depictions is handled by ChemDraw, ChemWindows
and many other chemical drawing programme. There CACTVS system contains a good free
graphical editor for creations of smiles on some common unix platforms.
The ability to convertion of Smiles to 2D depictions is less common. There Daylight
WWW page http://www.daylight.com provides a simple Web page for this. The following
tools are also available for the PC environment.

Consisant	Exographics USA
Accord		Synopics UK
Unity		Tripos USA
Depict-Toolkit	Daylight

The Best utility I have found for the general conversion between the various 2D
formats Babel released by the Dept. of Chemistry, University of Arizona,Tucson, AZ
85721	babel@mercury.aichem.arizona.edu	(source code is available)

Yours Robert Shell

Research Computing, 
Dagenham Research Centre 
Rhone Poulenc Rorer UK


From owner-software@net.bio.net Sat Feb 03 22:00:00 1996
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From: Ewan Birney <birney@molbiol.ox.ac.uk>
Newsgroups: bionet.software,bionet.software.gcg
Subject: PairWise and SearchWise 1.5 beta release
Date: Sun, 04 Feb 1996 18:14:21 +0000
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Xref: biosci bionet.software:14626 bionet.software.gcg:1606

**** PairWise and SearchWise 1.5 Release   ****
         ***                                       ***


   This is to announce the beta release of PairWise and SearchWise.

        The programs PairWise and SearchWise are based around an
algorithm which compares a Protein Profile to a DNA sequence,
*allowing* for frameshifts and introns in the DNA sequence. As a
protein profile can be trivially made from a protein sequence, both
PairWise and SearchWise can use a protein sequence as a query.

        This is the first proper beta release for PairWise and
SearchWise.  Although there are a variety of bugs to be worked out,
and many aspects to improve, the core of PairWise and SearchWise is
probably robust enough to be used on additional sites with not too
much work :)

        PairWise also comes with Profileweight code in-built, which
has many options for the optimisation of profile production.

        More information on PairWise and SearchWise can be found at

        http://www.ocms.ox.ac.uk/~birney/wise/topwise.html

which includes a WWW based server for you to try out PairWise queries
at

        http://www.ocms.ox.ac.uk/~birney/wise/hwise.html

and binaries can be found at the ftp site

        nmrz.ocms.ox.ac.uk in /pub/wise but I would read the hypertext
help first!

        See the README file on the ftp site or any of the source code
files for copyright (it is also on the WWW site). It is free for both
academic and commerical users, but commerical users must register
first.
        
        As a teaser, in one SearchWise run we discovered around 40% of
the ESTs with a PH domain to contain frameshifts, almost certainly due
to seqeuncing errors.  These sequences were unlikely to be seen
without SearchWise - although the GCG Framesearch program can cope
with frame shifts it cannot use the more sensitive profile methods
which can find distantly related sequences.

        PairWise and SearchWise are designed to work either as
stand-alone programs or in the GCG sequence analysis
enviroment. PairWise can be linked to GCG8 at compile time.
SearchWise can read GCG databases (ascii or binary), fasta databases
or EMBL databases.

        PairWise and SearchWise are written in ANSI C and developped
concurrently on SunOS, IRIX and AXP VMS platforms. Digital UNIX seems
to require no changes. It is likely that programs are easily ported to
any platform with an ANSI C compiler.

        The front ends (PairWise and SearchWise) have been tweaked
with to make sure that novice users can easily grasp what to do and 
not to make (too many) mistakes early on. However the user is given
complete control over as many aspects as possible and can reset
virtually all options through a run time configuration system.

        There are a few bugs in: In these cases they are documented if
at all possible in both output and log files. I respond quite quickly
to bugs: any suggestions are also very wellcome. 


        I hope you find the package as useful as we have over the years.


Author/Programmers:

        Ewan Birney (Oxford)
        Julie Thompson (EMBL)   

Author/Developper/Guru and Lead Bug tester ;)

        Toby Gibson (EMBL)

From owner-software@net.bio.net Sat Feb 03 22:00:00 1996
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From: krasel@wpxx02.toxi.uni-wuerzburg.de (Cornelius Krasel)
Newsgroups: bionet.software
Subject: Re: boxshade or similar
Date: 4 Feb 1996 14:18:03 GMT
Organization: University of Wuerzburg, Germany
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Danny Chamovitz (chamo) wrote:
> Does anyone know of a BOXSHADE type of program for Mac or UNIX?  BOXSHADE is a
> freeware that foramts alignments with black and grey boxes showing sequence
> conservation.

Boxshade is apparently available for unix. Check out bionet.software.gcg
for a recent thread.

--Cornelius.

-- 
/* Cornelius Krasel, U Wuerzburg, Dept. of Pharmacology, Versbacher Str. 9 */
/* D-97078 Wuerzburg, Germany   email: phak004@rzbox.uni-wuerzburg.de  SP3 */
/* "Science is the game we play with God to find out what His rules are."  */

From owner-software@net.bio.net Sat Feb 03 22:00:00 1996
Newsgroups: bionet.software
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!uchinews!woodlawn!sjchmura
From: sjchmura@woodlawn.uchicago.edu (steven joseph chmura)
Subject: Re: [Q]:?how to run MAC SW on PC (Windows95)
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References: <4eprqm$kes@mserv1.dl.ac.uk> <31114385.41C6@rhapsody.stanford.edu> <a337ard-0202961404310001@ka2-05.amc.uva.nl>
Date: Sun, 4 Feb 1996 20:26:45 GMT
Lines: 30

In article <a337ard-0202961404310001@ka2-05.amc.uva.nl>,
ard jonker <a337ard@horus.sara.nl> wrote:
>In article <31114385.41C6@rhapsody.stanford.edu>, Lionel Gilet
><gilet@rhapsody.stanford.edu> wrote:
>
>> In article <4eprqm$kes@mserv1.dl.ac.uk>, Ivo Wiesner  <nfix@jcu.cz> wrote:
>> >Could anybody inform me:
>> >1. if there is any emulator for PC (Windows) platform
>> >which enables running MAC software?
>> >2.how difficult work represents to rewrite Mac software for Windows PC?
>> I have no idea concerning the first point.
>...
>You can run Executor, demo ftp-able from ARDI. Basically, it resembles the
>speed of a Mac II under system 6 when used on a 66MHz 486. So you turn
>your PC into a '86 Mac. Don't ask me on how to set it up, I have no PC
>experience other than have tested Executor once ;-) It might do some jobs.
>Have a look from the other side (ie. the other way around, softwindows on
>a PPC runs a bit faster yet giving access to both platforms
>simultaneously)
>
Well, this is just plain wrong.  The registered version is far faster.  And
with a P5-133 costing $350 (yes, you can buy a motherboard and P5-133 for 
$500) the "exectutor" runs 680x0 apps as fast as a $1000 PowerMac.

Apple is in deep deep trouble - face it.  The Amiga of the '90s.
Softwindows is horrible and requires 16megs of RAM.            

-- 
________________________________________________________________________________Steven Chmura		                                       MuDPhud4
TEAM APACHE: To hell with jets

From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
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From: mikeb@innotts.co.uk (mike)
Newsgroups: bionet.software
Subject: enhance software --- NEW !!!!
Date: Mon, 05 Feb 1996 22:58:25 GMT
Organization: The Bridge
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http://www.innotts.co.uk/enhance/software/software.htm

enhance@innotts.co.uk

Internet Applications For Windows FTP.IRC.E-MAIL.
HTML.ARCHIE.NEWS.WEB.TERMINAL.FINGER.VRML.TALK.
PLUG-IN.GRAPHICS.ART.AUDIO.GOPHER.


From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
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From: rpgrant@molbiol.ox.ac.uk (Mad Dan Eccles)
Newsgroups: bionet.software
Subject: Re: [Q]:?how to run MAC SW on PC (Windows95)
Date: 5 Feb 96 08:42:30 GMT
Organization: Oxford University Molecular Biology Data Centre
Lines: 40
Message-ID: <1996Feb5.084230@molbiol.ox.ac.uk>
References: <4eprqm$kes@mserv1.dl.ac.uk> <31114385.41C6@rhapsody.stanford.edu> <a337ard-0202961404310001@ka2-05.amc.uva.nl> <DM9q4L.3Bq@midway.uchicago.edu>
NNTP-Posting-Host: ania.path.ox.ac.uk

sjchmura@woodlawn.uchicago.edu (steven joseph chmura) writes:
>>
> Well, this is just plain wrong.  The registered version is far faster.  And
> with a P5-133 costing $350 (yes, you can buy a motherboard and P5-133 for 
> $500) the "exectutor" runs 680x0 apps as fast as a $1000 PowerMac.

Well, I don't know about that, but I do know you can buy a PowerMac with 486 
DOS card for GBP1300 - and probably cheaper in the US.  If I was buying, I'd 
get a PMac w/ 486 card, maybe a P5 card.

Two more points: 
One:
for $$/computing power, PowerMacs are far faster than P5s, which is not 
surprising because of the RISC technology.  I mean, who wants two 486s 
soldered back to back?? At least it keeps the room warm in winter. :)

Two:
To make a P5 costs TWICE as much as making a PowerPC chip.  Again, the 
technology accounts for this.

> Apple is in deep deep trouble - face it.  The Amiga of the '90s.

Bull.  Go tell that to 20 million happy users.  They shifted more units last 
quarter than ever before, and over a million PowerMacs.  OK, they made a $70 
million loss which is bad news but that was a forecasting problem (they 
overestimated demand, which cancelled out the underestimation of earlier last 
year when they had backorders totalling 1 _billion_ US$).  Cf with a $122 
million _profit_ for the same quarter the previous  year, I don't think they're 
struggling.  Spindler's gone, so they _shouldn't_ make the same mistakes 
again.  They've licensed the MacOS and now well respected companies such as 
UMAX (btw, they make a MEAN colour scanner, fantastic) are making 
Mac-compatibles - so we should see even more real computers around.

> Softwindows is horrible and requires 16megs of RAM.            

Hm, just like Win95? ;-)


Happy computing,
Richard

From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
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From: Reno Pontarollo <Reno.Pontarollo@dres.dnd.ca>
Newsgroups: bionet.software
Subject: Wanted:  public DNA alignment/primer design software
Date: 5 Feb 1996 17:05:23 GMT
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I already use MACAW 2.05 for DNA alignment, but could use some more software.

I have access to a UNIX system and was wondering what the CLUSTAL and FASTA packages are 
capable of and how easy they are to use.


From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
Path: biosci!daresbury!is.bbsrc.ac.uk!news
From: <Unknown> (Ken INUI)
Newsgroups: bionet.software
Subject: Re: boxshade or similar
Date: 5 Feb 1996 14:03:37 GMT
Organization: IAH Pirbright
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In article <4etkns$n7g@news.ycc.yale.edu>, Danny Chamovitz <chamo> says:
>
>Does anyone know of a BOXSHADE type of program for Mac or UNIX?  
BOXSHADE is a
>freeware that foramts alignments with black and grey boxes showing 
sequence
>conservation.
>

The BOXSHADE distribution contains the full source code, including OSF1 
makefile. You will need to have your own PASCAL compiler. If it does not 
compile on your particular flavour of UNIX, please tell me what the 
offending code is, and I'll try and work something out. You can get the 
distribution from the EMBL software archive in the VMS directory.

I'm (_very slowly_) working on a MAC version, but it's just a hobby. The 
latest version of BOXSHADE, which I'll put in the EMBL archive when I get 
the time, writes PICT files.

regards,

Michael D. Baron 
michael.baron@bbsrc.ac.uk

From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
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Newsgroups: bionet.software
Message-ID: <241@phoretix.win-uk.net>
References: <s110eb1c.096@EM.AGR.CA>
Reply-To: nonlin@phoretix.win-uk.net (Will Dracup)
From: nonlin@phoretix.win-uk.net (Will Dracup)
Date: Mon, 05 Feb 1996 11:30:43 GMT
Subject: Re: Information on DNA Analysis Software
Lines: 51

In article <s110eb1c.096@EM.AGR.CA>, Graham Casey (GCasey@EM.AGR.CA) writes:
>Hello everyone:
>
>We are considering implementing an image capture system to store the
>data generated in our gels in digital form.  We have been given some
>advice regarding the types of software that we can use to "clean up the
>image" (ie., adjust contrast etc), but we do not have much information on
>software to do some of the actual data analysis.
>
>Generally, we would be interested in the basic functions of molecular
>weight/ fragment length determination, DNA sequence reading, sequence
>alignment, RFLP and RAPD fragment analysis running on a 486 and or
>Pentium PC.  (We're not asking for much, are we :)!)  We would
>appreciate it if any of you can suggest some software packages,
>companies or web sites we could look at; or even some of your own
>experiences with a given software package(s).
>
>Thanks in advance for any help or advice.
>
>Graham Casey
>Cereal Research Centre
>Agriculture Agri-Foods Canada
>gcasey@em.agr.ca
>

Phoretix International is British company who have been developing
electrophoresis image analysis software for PC’s since 1989.

Both our 1D and 2D software packages are specifically designed for
the in depth analysis of electrophoresis gels.  We can import images
in 8, 12 or 16 bit formats from many forms of image capture device,
such as commercial document scanners, CCD cameras, phosphor imagers
and laser densitometers.  For visualisation purposes, the image can
then be "enhanced" using contrast stretching, false colours,
negative images or zooming in to look at a very few pixels. 
However the image data itself is never altered since the software
was developed to operate within the confines of Good Laboratory
Practice. 

Spots or bands can be automatically detected and measured, and
quantity, MW, and many othermeasurements calculated.  Histograms,
dendrograms, comparison tables and other forms of displaying the
data make the results easily assessable in a clear and instantly
recognisable way. 

I am afraid our web site is currently under construction but do
e-mail me with any questions you may have, or send me your address
so that I can forward you further information and a demo disk. 

James Sykes  



From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
Path: biosci!daresbury!not-for-mail
From: nolan@cyberlearn.com (Ron S. Nolan)
Newsgroups: bionet.software
Subject: FS: Marine Life Investigations
Date: 5 Feb 1996 11:21:34 -0000
Lines: 260
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Distribution: bionet
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Original-To: bio-software@dl.ac.uk

Coral Kingdom 1.1

Announcing a new CD-ROM for Macintosh and Windows that offers an exciting
venture into the marine world of the coral reef.

Why Study Coral Reefs?

Coral reefs are well defined ecosystems that provide concise examples of
energy flow and materials recycling as well as the complex
interrelationships between organisms and the environment.  Since coral reef
plants and animals have developed specialized adaptations for feeding,
reproduction and predator avoidance that permit very high biodiversity in a
limited geographic area, the study of the coral reef is ideally suited for
units on adaptations, biodiversity and competition.

=46inally, coral reefs and their inhabitants are strikingly interesting,
beautiful and exotic.  They are wild, colorful places that excite the
imagination.   The software has been carefully crafted to challenge
students to use critical thinking about nature and the environment.  To
paraphrase one reviewer's comment,  "Coral Kingdom is not a game.  It is a
serious academic program."

The Coral Kingdom package offers you many ways to incorporate the software
into your curriculum.  The extensive, 179 page Teachers Guide is packed
with ideas and activities.  Transcripts of the program content allow you to
turn off the sound and provide your own expert commentary.  And since the
topics are thematically arranged, you may select assignments that will
illustrate some of the most important concepts in biology and ecology.


"Coral Kingdom is a serious academic program.  It asks students to do some
real scientific thinking."  Technology and Learning.  "If...you are looking
for thematic units in science, then you should examine Coral Kingdom."  The
Computing Teacher.  "Stunning visuals, detailed narration and excellent
supplemental reference materials guide exploration of a coral reef, its
biology and its ecology.  MacUser "The Ultimate Guide to Children's
Software" 4 mice.

=46eel free to request a flyer or copies of educational journal reviews by
calling Digital Studios at (800) 499-3322 or by sending e-mail with your
address to

nolan@cyberlearn.com

You may preview Coral Kingdom and download a demo version at our Web Site.

http://www.netins.net/showcase/macintosh/cyblearn.htm


Special Note to California Educators

Coral Kingdom has recently been awarded a "Desirable" rating by the State
of California Software Clearinghouse.  The program has also been certified
as in compliance with social content requirements of Education Code
sections 60040=3D66044.  Placement on this list notifies school personnel
that Coral Kingdom is approved for purchase with up to 30% of their state
Instructional Materials Fund (IMF) monies or through petitions requested
through the California Department of Education.

CORAL KINGDOM FEATURES
--------------------------------------
Thematic Approach to Biology and Ecology: Created by a marine ecologist,
the software incorporates a tremendous collection of original underwater
photography to illustrate a thematic approach to the study of reef biology
and ecology.

The software is ideally suited for units on the coral reef or to
demonstrate the concepts of form and function in adaptations,
interrelationships between organisms and habitat, competition, predator
avoidance, energy and materials cycles and human impacts in general biology
or introductory environmental science or ecology classes.

Missions:  Each of the four units incorporates a hands-on activity to be
completed by students--either in small groups or individually.  Each
mission consists of an exploratory microworld intended to stimulate the
curiosity of students and to engage their interest in the  natural world.
The methods used by the students at the computer are much like those
actually employed by a field ecologist.

Each of the four missions takes the user on a research SCUBA dive in which
he or she controls the direction and pace of the investigation.  The
procedures to be followed and mission objectives are described in detail
within the unit sections of the teachers guide and can be  accessed by
clicking the "?" button during a mission.  An on-line notebook is provided
in which students store information acquired by clicking  objects on the
screen during the underwater expedition.  The content of the notebook may
be saved as a text file, then edited or printed using a word processor
program.

Sea Life Catalog:  Students have access to an extensive data base which is
available for reference at all  times.  Problems to be solved in the
missions require students to conduct library research using the data base.
Species entries in the Sea Life Catalog are accessed by scientific or
common names.  Each Sea Life Catalog entry provides information about an
organism's structure, coloration, relationship to the  environment,
behavior, specializations and human impact.  The catalog may be accessed
from any map or from the slide shows by clicking on the "SLC" button.  In a
mission, the SLC button lights after the user has clicked on a subject on
the screen.   Clicking the highlighted SLC button during a mission takes
the user directly to information about the organism on the screen.

Study Units:  The program content is thematically presented and organized
into four major units.  Each unit consists of a series of multimedia slides
shows and is accompanied by a research activity.

Unit 1:  Discovering Adaptations introduces the theme that structure
matches function and presents an overview of the diversity of sizes,
shapes, colors and lifestyles found on a coral reef.  In this unit we
explore the relationship of species to the environment--in  particular
adaptations in feeding and coloration.  In Mission: Kohala Coast, the user
makes underwater observations, then uses the Sea Life Catalog to find the
unique adaptations of the selected organisms.

In Unit 2:  The Coral Reef Ecosystem, we look at how reefs are formed and
the vertical distribution of organisms on the reef face.  We also seek to
understand the living and non-living forces that build reefs and break them
down.  Finally we explore how solar energy is captured and transmitted
through the ecosystem.  The activity for this unit, Mission: Marshall
Islands, challenges students to make underwater observations in order to
develop a species list, then fit the organisms into a food web.

Unit 3:  Investigating Interrelationships examines the ways in which
organisms interact with the biotic and abiotic environment.  We explore
competition for food and habitat and the concept of the Competitive
Exclusion Principle--as well as symbiotic relationships.    Finally, we
examine structural and behavioral adaptations and the survival strategies
employed by a wide diversity of organisms.  In the activity, Mission: South
Point,  students speculate about how superficially similar species of
butterflyfishes are able to  live in close proximity.

In Unit 4:  Exploring Human Impacts, we examine the environmental impacts
of  development, fishing and diving.  We also survey the present status of
reef ecosystems in the Pacific and Atlantic and learn why reefs are
important to the planet and the human species.  Finally we offer
suggestions on what can be done to  protect imperiled coral reefs.  In
Mission: Reef Preservation, students discover human activities that may
negatively impact coral reef ecosystems.

Incorporation into Existing Curricula:  CORAL KINGDOM 1.1 was designed for
flexible incorporation into existing academic programs.  Ranging from
straight forward activities (discovering the relationship of structure and
function in adaptations) to the complex (investigating how butterflyfishes
avoid competition), the teacher may pick and choose from twenty hours of
suggested  activities.  The materials may be used to introduce a unit on
ecology in general biology classes or as a case study in environmental
science and ecology courses. The  hypermedia format of the program allows
instructors to select topics of particular interest for either classroom
presentation or individual study.

As part of the design enabling flexible application, teachers may use a
special feature to turn off the audio when presenting the slide shows in
group settings.  To support this feature, transcripts of the narration are
provided in the teachers guide providing a valuable source for lectures.
When used in this fashion, the slide shows serve as an extensive visual
database of underwater imagery which may be quickly accessed during the
lecture.

Students who fully explore the slide shows and participate in the research
missions will gain a solid understanding of some of the most important
themes of ecology  This experience will, hopefully, lead them to the
conclusion that coral reefs are precious resources worthy of our
protection.

Product Information

CD-ROM for Macintosh and Windows from the CyberLearning Collection=81
Age Level:  middle through first year college
Developer/Publisher:  Digital Studios=81
Product Orders:  (800) 499-3322
Pricing:  CD-ROM for Mac or Windows with 179 page Teachers Guide--$79.95;
Multiple Lab Pack Discounts are Available
Availability:  Now
More Information:  Digital Studios * 209 Santa Clara Avenue * Aptos * CA
95003 * (408) 688-3158

Save with Special Lab Pack Pricing

Options                 Unit Price           Shipping    FEDEX**

A.      Single Edition*    79.00                5.58            11.00

B.      Lab Pack (5)*         158.00            5.74            12.65
        5 CD-ROMs

C.      Lab Pack (10)*     237.00             5.86       15.45
        10 CD-ROMs

D.      Lab Pack (20)*      315.00            6.00               19.80
        20 CD-ROMs

E.      Lab Pack (35)*     395.00             6.25              25.05
        35 CD-ROMs

=46.      Extra guides           20.00          5.58            11.00

*  Each Option is accompanied by a Teachers Guide.
**FEDEX rate is for next day standard.  FEDEX orders must be received by 2
PM PST for next day delivery.

Sales in California please add 8.25% to total price.  Hawaii orders, please
call to discuss the fastest and most cost effective way to get Coral
Kingdom back to Hawaii.


------------------------------------------------------------------
Evaluation by the California Software Clearinghouse 1995

Rated "Desirable"

TITLE:  Coral Kingdom 1.1

DESCRIPTION:  The goal of this simulation is to explore the principle
themes of marine ecology and the environmental impact of human activities.
The program tour provides a clear introduction to information that is
organized logically by traditional pathways (kinds of organisms), major
concepts (ecological themes), and projected learning pathways (way students
are most likely to want to move from section to section and back again).
Logistically the program is easy to navigate.  It can be adapted for whole
class use, small group investigations using the missions, or as an
independent resource for individuals.  Slide shows present information
around major concepts and themes:  adaptations, interactions, ecological
systems, human impact. Missions stimulate scientific observations and are
organized around "diving" at investigation sites in Hawaii and Micronesia.
Students view slides with hot spots to focus on important ecological
information.  They collect information about the inhabitants offshore in
shallow to deep waters.  A student notebook facilitates systematic
information gathering and notes can be incorporated in a complete
scientific report.  The fourth mission involves identifying and solving
problems related to human impact and reef preservation.  As a logistics
aid, dives are limited to "twenty minutes of air time" each.  A Sea Life
catalog provides a database of nearly one hundred organisms listed by
common and scientific name with information on habitat, ecological niche,
impact on/by humans, behaviors and other interesting details.  One drawback
is that progression through the slide show is linear and it is difficult to
access specific slides out of sequence.

SUPPORT MATERIALS:  There is a CD-ROM and a teacher's manual with guides to
the slide shows and missions, suggested classroom uses, report form,
scripts, and suggested readings.

SYSTEM REQUIREMENTS:  IBM:  4MB with 386 or better processor, Windows,
sound capability, VGA graphics, hard drive, and CD-ROM drive.  Macintosh:
4MB, CD-ROM drive, and color monitor.

CURRICULUM APPLICATIONS:  This would be an excellent resource in a library
media center or science lab.  It supports the thematic approach of the
California science framework.  Activities offer hands-on experience in
gathering and analyzing scientific data.  The program is very
text-dependent and requires a prior understanding of biological terms.
Students who love details would absorb it all,  while others can appreciate
the big ideas that are reinforced by example throughout.  Consistency of
format allows individual comparisons to be made, and the photos provide a
wealth of pictorial examples for the embedded tasks as well as other uses
the instructor might have when connecting this program with other students
of varying verbal abilities.  Teachers can use the program for direct
assignments, independent resource material, or presentation of specific
information.  The control can be given to students with excellent results.
It fits nicely in a constructivist learning environment.



From owner-software@net.bio.net Sun Feb 04 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!rice!cs.rice.edu!schaffer
From: schaffer@cs.rice.edu (Alex Schaffer)
Newsgroups: bionet.molbio.gene-linkage,bionet.software
Subject: FASTLINK 3.0P available
Date: 5 Feb 1996 22:26:02 GMT
Organization: Rice University
Lines: 112
Message-ID: <4f605q$83a@larry.rice.edu>
NNTP-Posting-Host: cs.rice.edu
Xref: biosci bionet.molbio.gene-linkage:962 bionet.software:14634

I am pleased to announce that FASTLINK 3.0P is now available.
FASTLINK is an improved version of the linkage analysis package
LINKAGE 5.1, which is 
    --faster sequentially than LINKAGE, 
    --runs well in parallel, 
    --is more robust against errors, and 
    --includes substantial new documentation

The initial improvements that led to FASTLINK 1.0 are described in:

1. R. W. Cottingham Jr., R. M. Idury, and A.A. Schaffer, Faster Sequential
Genetic Linkage Computations, American Journal of Human Genetics, 53(1993),
pp. 252-263. (available as paper1.ps in the distribution)

The improvements that led to FASTLINK 2.0 are described in:

2. A.A. Schaffer, S. K. Gupta, K. Shriram, and R. W. Cottingham, Jr.,
Avoiding Recomputation in Linkage Analysis, Human Heredity, 44(1994), pp.
225-237. (available as paper2.ps in the distribution)

The improvements that led to FASTLINK 3.0 are described in:

3. A. A. Schaffer, Faster Linkage Analysis Computations for Pedigrees
with Loops or Unused Alleles, Human Heredity, to appear. (available
as paper5.ps in the distribution)

We ask that you cite papers 1 and 2, as well as at least one paper
about LINKAGE, if you use FASTLINK in a published experiment.

paper3.ps and paper4.ps in the distribution describe how FASTLINK runs
in parallel.

As with previous versions, the code is available by ftp from:
   softlib.cs.rice.edu 

Login as anonymous, leave full e-mail address as password.  
   cd pub/fastlink

If you are a UNIX user:
   get fastlink.tar.Z

If you are a DOS user:
   cd dos
   <retrieve everything in that directory>

If you are a VMS user:
   get README
   get README.VMS
and follow the instructions there for what you need

Retrievers in Europe may find it more convenient to retrieve from the
mirror site at:
   ftp.ebi.ac.uk

The instructions are similar, but instead of:
   cd pub/fastlink   (for softlib)
do
   cd pub/software/linkage_and_mapping/FASTLINK/fastlink  (for ebi)

It takes up to 24 hours for the contents of the Rice site to get updated
at the U.K. mirror site.

Among the improvements in FASTLINK 3.0P (compared to 2.3P) are:

   -- The code runs faster on data sets that have loops or unused alleles
      If you used FASTLINK 2.3P, you may have noticed that it printed
      diagnostics when a data set had unused alleles, but it did not take
      advantage of the situation.

   -- UNKNOWN now detects violations of Mendelian rules of inheritance
      in looped pedigrees. It never did this before.

   
   -- maxhap and maxfem are no longer in the code as constants, except in
      UNKNOWN. If you were resetting maxhap each time and recompiling, you
      won't have to do that any more. If you were setting maxhap unnecessarily
      high to avoid recompiling, you may perceive some speedup.

   -- The code can now handle more than 31 alleles at a numbered allele
      locus. It still can't handle more than 31 alleles at a binary factors
      locus. More than 31 liability classes or quantitative trait classes
      have not been a problem.

   -- The parallel code can now handle data sets with an arbitrary number 
      of loops.


   -- The constant MAXWORKINGSET was eliminated from the parallel code.
      The net effect is to save space in most cases, and reduce the
      need for recompilation in some.

See the file README.updates for more details on recent code changes in 
FASTLINK. 

There are many people to thank for their recent help in the FASTLINK project.
Thanks to:

Dylan Cooper, Christopher Hoelscher, and Christopher Hyams
for programming assistance.

Lucien Bachner, Les Biesecker, Anita Destefano, Lynn Goldin,
Ramana Idury, Kimmo Kallio, Cathryn Lewis, Ken Morgan, 
Scot Stenroos, Jim Tomlin, Gerard Tromp for beta testing version 3.0P.

Jeff O'Connell and Joe Terwilliger for pointing out the 31-allele limitation.

Lucien Bachner for pointing out that UNKNOWN did not detect errors
in looped pedigrees.

Please address any comments or questions about FASTLINK to me at:
schaffer@nchgr.nih.gov. 


From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!usenet.eel.ufl.edu!psgrain!iafrica.com!slipper12253.iafrica.com!tjones
From: tjones@iafrica.com (Tim Jones)
Newsgroups: bionet.software
Subject: COPYIIPC - or equivalent for Stiffies?
Date: Tue, 6 Feb 1996 15:05:13
Organization: Internet Africa
Lines: 7
Message-ID: <tjones.3.000F16B2@iafrica.com>
NNTP-Posting-Host: slipper12253.iafrica.com
X-Newsreader: Trumpet for Windows [Version 1.0 Rev A]

Hi,
Does anybody remember copyiipc - a disk copying programme ? Well I need one 
with similar capabilties but for 1.4 Stiffies. Any suggestions?

The software I am trying to backup, won't with diskcopy etc.

Thanks, Tim

From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Newsgroups: bionet.software
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!rome.netwide.net!not-for-mail
From: Michael Banditt <banditt@cell.biol.ethz.ch>
Subject: GCK
Message-ID: <3115CA70.2F64@cell.biol.ethz.ch>
Date: Mon, 05 Feb 1996 10:14:24 +0100
Organization: IZB ETH Zurich
X-Mailer: Mozilla 2.0b6a (Macintosh; I; PPC)
MIME-Version: 1.0
Content-Type: text/plain; charset=us-ascii
Content-Transfer-Encoding: 7bit
Lines: 11

Hello!

Does anybody have some experience with the "Gene Construction Kit" 
for the MacIntosh? We are currently evaluating this program and 
would like to hear some other opinions. 

--
Michael Banditt                   Phone:  +41-1-633-3345
Institute for cell biology        Fax:    +41-1-633-1069
Swiss Institute of Technology     Email:  banditt@cell.biol.ethz.ch



From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Newsgroups: bionet.software
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!hookup!news.nstn.ca!news.cs.indiana.edu!umn.edu!dialup-16-a-15.gw.umn.edu!user
From: velaz001@maroon.tc.umn.edu (Ruben A. Velazquez)
Subject: Re: want mac software sites
Message-ID: <velaz001-0602960109230001@dialup-16-a-15.gw.umn.edu>
Sender: news@news.cis.umn.edu (Usenet News Administration)
Nntp-Posting-Host: dialup-16-a-15.gw.umn.edu
Organization: UMN
References: <jlepine-0202961003280001@s219.haverford.edu> <96020308175880@pcc.awinc.com>
Date: Tue, 6 Feb 1996 06:09:23 GMT
Lines: 14

In article <96020308175880@pcc.awinc.com>, bryan.webster@pcc.awinc.com
(Bryan Webster) wrote:

> -> From: jlepine@haverford.edu
> -> Subject: want mac software sites
> ->
> -> I really need a www site where I can download MACINTOSH software.
> -> Everything I try to download turns out to be for other systems.
> -> jlepine@haverford.edu
> When you are on the www next, try using one of the search systems
> such as YAHOO to locate sites with MAC software.


Try http://www.shareware.com/

From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Path: biosci!bloom-beacon.mit.edu!gatech!newsfeed.internetmci.com!howland.reston.ans.net!nntp.coast.net!harbinger.cc.monash.edu.au!news.mel.connect.com.au!munnari.OZ.AU!metro!metro!dchamber
From: dchamber@extro.ucc.su.oz.au (Dianne Chambers)
Newsgroups: bionet.software
Subject: Re: Biology Education Software FAQ
Date: 6 Feb 1996 04:21:53 GMT
Organization: The University of Sydney
Lines: 30
Sender: dchamber@linnaeus.bio.usyd.edu.au.
Distribution: inet
Message-ID: <4f6l11$aom@metro.usyd.edu.au>
References: <4ep0h8$lqn@nntp3.u.washington.edu>  
 <4f0cs8$k7p@bbs.dordt.edu>
NNTP-Posting-Host: ntbt.bio.usyd.edu.au
X-Posted-From: InterNews 1.0@0.0.0.0.in-addr.arpa.

I am part of UniServe*Science which is an Australian  group whose role
includes finding and evaluating software packages that could be used in
undergraduate science teaching.  I look after biology, biochemistry,
and psychology.

Thus, I too have been tracking down software for teaching undergraduate
biology.

Our database can be searched at
http://129.78.153.144/ROFM_CGI/search.html or visit our site at
http://www.usyd.edu.au.su/SCH

I'd love to hear about any other software (or videodiscs) for teaching
undergraduate science, in particlular if it is a package you have used
and would recommend.

Cheers,

Dianne Chambers

---------------------------------------------------------------------
Contact details:
   Dr Dianne Chambers
   UniServe*Science (F07)
   The University of Sydney
   NSW 2006
   AUSTRALIA
   Tel:   61 2 351 2960
   Fax:   61 2 351 2175
   email: dchamber@extro.ucc.su.oz.au

From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!uwm.edu!usenet
From: youngmin@csd4.fsu.edu
Newsgroups: bionet.software
Subject: REQ: Reference Manager for Windows
Date: Tue, 06 Feb 1996 23:12:46 GMT
Organization: University of Wisconsin - Milwaukee
Lines: 3
Message-ID: <4f8g42$s81@uwm.edu>
NNTP-Posting-Host: 129.89.8.202
X-Newsreader: Forte Free Agent 1.0.82

I am a bio student. I badly need RF for windows.
I will have something in return.


From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Newsgroups: bionet.software
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!primus.ac.net!news.cais.net!xara.net!peer-news.britain.eu.net!strath-cs!bradford.ac.uk!leeds.ac.uk!news
From: bmb5meb@bmb.leeds.ac.uk (Michael Beck)
Subject: Re: MS-Dos or Windows 95 software
Message-ID: <1996Feb6.121419.23735@leeds.ac.uk>
Reply-To: bmb5meb@bmb.leeds.ac.uk
NNTP-Posting-Host: bmbaxp.leeds.ac.uk
Organization: The University of Leeds, UK
Date: Tue, 6 Feb 1996 12:14:19 +0000 (GMT)
References: <1996Feb6.121149.21976@leeds.ac.uk>
Lines: 16

In article <1996Feb6.121149.21976@leeds.ac.uk>, bmb5meb@bmb.leeds.ac.uk (Michael Beck) writes:
>Hi,
>
>I'm trying to locate some software which I can run either under MS-Dos or
>Windows 95. The software I need is a UUencoder/decoder and a C compiler. If
>anyone can give me pointers to FTP sites where either of these are available
>I'd appreciate it.
>
>Mike.

Sorry, I forgot my .sig with e-mail address.

Michael Beck (Leeds University Archery Team) :     ___   
Protein Database Group,                      :    <*,*>    Home of the OWL 
University of Leeds                          :    [`_']    protein database.
e-mail : bmb5meb@bmb.leeds.ac.uk             :    _"_"_

From owner-software@net.bio.net Mon Feb 05 22:00:00 1996
Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!metro!metro!dchamber
From: dchamber@extro.ucc.su.oz.au (Dianne Chambers)
Newsgroups: bionet.software
Subject: Re: Biology Education Software FAQ
Date: 6 Feb 1996 22:35:02 GMT
Organization: The University of Sydney
Lines: 15
Sender: dchamber@linnaeus.bio.usyd.edu.au.
Distribution: inet
Message-ID: <4f8l2m$h3h@metro.usyd.edu.au>
References: <4ep0h8$lqn@nntp3.u.washington.edu> 
 <4f0cs8$k7p@bbs.dordt.edu>  <4f6l11$aom@metro.usyd.edu.au>
NNTP-Posting-Host: ntbt.bio.usyd.edu.au
X-Posted-From: InterNews 1.0@metro.ucc.su.oz.au.

Sorry, the second URL should have been

http://www.usyd.edu.au/su/SCH


---------------------------------------------------------------------
Contact details:
   Dr Dianne Chambers
   UniServe*Science (F07)
   The University of Sydney
   NSW 2006
   AUSTRALIA
   Tel:   61 2 351 2960
   Fax:   61 2 351 2175
   email: dchamber@extro.ucc.su.oz.au

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!elroy.jpl.nasa.gov!swrinde!gatech!newsfeed.internetmci.com!news.sprintlink.net!ralph.vnet.net!islpub.vnet.net!user
From: islpub@vnet.com (TeeMo)
Newsgroups: bionet.software
Subject: SOFTER WEAR!!!!
Date: 7 Feb 1996 00:25:38 GMT
Organization: Vnet Internet Access, Charlotte, NC - info@char.vnet.net
Lines: 16
Message-ID: <islpub-0602961933370001@islpub.vnet.net>
NNTP-Posting-Host: islpub.vnet.net

You're gonna be GLAD you been HAD, when you visit this site!

Sysop Softwear!

http://www.hiltonheadisland.com/sysop.htm

T-Shirts€ T-Shirts€T-Shirts€ T-Shirts€ T-Shirts€ T-Shirts€ 

T-Shirts made just for that special part of you that most people refer to as:
prefix:Computer-SPAZ! GEEK! or WIERDO!
Join The Worldwide Coalition of Systems Operators While It's on an
underground level.
and Check out my little slice of the American dream.
It's well worth the 30 seconds it takes to get there.

Questions?:   islpub@vnet.net

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!milo.mcs.anl.gov!jadoube.mcs.anl.gov!levine
From: levine@jadoube.mcs.anl.gov (David Levine)
Newsgroups: bionet.software
Subject: PGAPack V1.0, Parallel GA Software
Date: Wed, 7 Feb 1996 2:29:32 GMT
Organization: Math and Computer Science, Argonne National Laboratory
Lines: 25
Distribution: world
Message-ID: <82366017219610@jadoube.mcs.anl.gov>
NNTP-Posting-Host: jadoube.mcs.anl.gov

PGAPack is a general-purpose, data-structure-neutral, parallel genetic
algorithm library.  It is intended to provide most capabilities desired in a
genetic algorithm library, in an integrated, seamless, and portable manner.
Key features include:

* Callable from Fortran or C.
* Runs on uniprocessors, parallel computers, and workstation networks.
* Binary-, integer-, real-, and character-valued native data types.
* Full extensibility to support custom operators and new data types.
* Easy-to-use interface for novice and application users.
* Multiple levels of access for expert users.
* Parameterized population replacement.
* Multiple crossover, mutation, and selection operators
* Easy integration of hill-climbing heuristics. 
* Extensive debugging facilities.
* Large set of example problems.
* Detailed users guide

PGAPack is available:
  -- via anonymous ftp from ftp.mcs.anl.gov in file pub/pgapack/pgapack.tar.Z
  -- via the web at http://www.mcs.anl.gov/pgapack.html 

David Levine     levine@mcs.anl.gov      http://www.mcs.anl.gov/home/levine
MCS 221 C-216    Argonne National Laboratory   Argonne, Illinois 60439
(708)-252-6735   Fax: (708)-252-5986

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.tamu.edu!news.utdallas.edu!geraldo.cc.utexas.edu!netnews.uthscsa.edu!netnews!garrisonp
From: garrisonp@uthscsa.edu (Preston Garrison)
Newsgroups: bionet.software
Subject: Re: boxshade or similar
Date: Wed, 7 Feb 96 03:43:16 GMT
Organization: Uthscsa
Lines: 15
Message-ID: <garrisonp.1174052236A@netnews.uthscsa.edu>
References: <4etkns$n7g@news.ycc.yale.edu>
NNTP-Posting-Host: bioc04.uthscsa.edu
X-Newsreader: VersaTerm Link v1.1.1

In Article <4etkns$n7g@news.ycc.yale.edu>, Danny Chamovitz <chamo> wrote:
>Does anyone know of a BOXSHADE type of program for Mac or UNIX?  BOXSHADE is a
>freeware that foramts alignments with black and grey boxes showing sequence
>conservation.
>....
You might try SeqVu for Mac. It's $10 shareware available at:

http://iubio.bio.indiana.edu:80/1/IUBio-Software%2bData/molbio/mac

Preston Garrison
garrisonp@uthscsa.edu
Biochem. Dept.
Univ of Texas Health Sci Ctr
San Antonio, Tx 78284-7760 USA
210-567-3702

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
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From: Brian Fristensky <frist>
Newsgroups: bionet.software
Subject: Re: Wanted:  public DNA alignment/primer design software
Date: 7 Feb 1996 18:59:00 GMT
Organization: University of Manitoba
Lines: 35
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References: <4f5dcj$670@coyote.dres.dnd.ca>
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Reno Pontarollo <Reno.Pontarollo@dres.dnd.ca> wrote:
>I already use MACAW 2.05 for DNA alignment, but could use some more software.
>
>I have access to a UNIX system and was wondering what the CLUSTAL and FASTA packages are 
>capable of and how easy they are to use.
>

I have built a comprehensive sequence analysis facility on our Sun/Unix
system using only freely-available software. I have written two packages:
  FSAP - general sequence analysis tasks
  XYLEM - sequence database creation and manipulation

These programs run from the command line, but can also be run from
Steven Smith's GDE (Genetic Data Environment). I have written a very
extensive set of GDE menus for running FSAP and XYLEM programs, as well
as other freeware programs (FASTA, PHYLIP, CLUSTAL, PIMA...) from 
GDE. 

For more information and to download software see:

http://home.cc.umanitoba.ca/~psgendb/


-- 
===============================================================================
Brian Fristensky                |  We've heard 3 or 4 times this morning that,
Department of Plant Science     |  out of 85,000 works funded by the NEA,
University of Manitoba          |  only 20 were controversial. I don't know
Winnipeg, MB R3T 2N2  CANADA    |  why anyone would cite that as something to
frist@cc.umanitoba.ca           |  be proud of.
Office phone:   204-474-6085    |  
FAX:            204-261-5732    |  Garrison Keillor, testimony to Congress in
http://home.cc.umanitoba.ca/~frist/  defense of Natl. Endowment for the Arts
===============================================================================


From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
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From: marty@ionchann (Marty Gallagher)
Newsgroups: bionet.software
Subject: Re: [Q]:?how to run MAC SW on PC (Windows95)
Date: 7 Feb 1996 15:55:09 GMT
Organization: Harvard University Office of Information Technology
Lines: 20
Distribution: bionet
Message-ID: <4fai0t$2hr@netope.harvard.edu>
References: <4eprqm$kes@mserv1.dl.ac.uk>
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X-Newsreader: TIN [version 1.2 PL2]

Search the net for a program called "executor."  There is a free demo available.

					-- Marty



Ivo Wiesner (nfix@jcu.cz) wrote:

: Hello Netters out there!

: Could anybody inform me: 

: 1. if there is any emulator for PC (Windows) platform
: which enables running MAC software?
: 2.how difficult work represents to rewrite Mac software for Windows PC? 

: Any info much appreciated.


: Ivo Wiesner

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
Path: biosci!daresbury!lyra.csx.cam.ac.uk!news
From: timc@chiark.chu.cam.ac.uk (Tim Cutts)
Newsgroups: bionet.software
Subject: Re: REQ: Reference Manager for Windows
Date: 07 Feb 1996 09:24:18 +0000 (GMT)
Organization: Linux Unlimited
Lines: 16
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Originator: timc@chiark.chu.cam.ac.uk (UNIX:@[131.111.131.114])

In article <4f8g42$s81@uwm.edu>,  <youngmin@csd4.fsu.edu> wrote:
>I am a bio student. I badly need RF for windows.
>I will have something in return.

I hope you're not advocating software piracy...  There are lots of
reference management programs about.  There are no free ones, but
there are one or two in the $50 price range.  And if you're telling me
you can't afford that much, I won't believe you!!! :-)

There's a good summary at:

http://www.peinet.pe.ca:2080/Chorus/Mega/m001.html

Regards,

Tim.

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
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From: username@terra.nlnet.nf.ca (Full name)
Newsgroups: bionet.software
Subject: Need help running WIN.95-help!!!
Date: 7 Feb 1996 07:34:45 GMT
Organization: Memorial University of Newfoundland
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I recently downloaded some files needed to finish installing the net.
Now when I start my computer I get a message saying that a windows registary
or System ini.file can no longer be found.
If by mistake, I erased this file, how can I get it back?
 ps. I tried installing win.95 again with same results.
     And also not in the Recycle Bin.
            NEED HELP

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!newsroom.utas.edu.au!dslip6.its.utas.edu.au!user
From: tim.barlow@lib.utas.edu.au (Tim Barlow)
Newsgroups: bionet.software
Subject: Beta Testers Required  - Electronic Forms for the Mac
Date: Wed, 07 Feb 1996 18:43:45 +1100
Organization: Barlow & Bond Enterprises
Lines: 78
Message-ID: <tim.barlow-0702961843450001@dslip6.its.utas.edu.au>
NNTP-Posting-Host: dslip6.its.utas.edu.au

Abstract
--------
Form is a suite of applications that implements electronic forms for the
Macintosh; it has three components.
 
The first application, the 'Generator' has a dual purpose. Firstly, it
provides facilities for the  creation, storage and testing of electronic
forms. Secondly, when one or more forms have been created and tested the
application may then be used to generate a 'Sender' application. This
application may be configured with one or more of the stored forms and is
essentially a cut-down version of the Generator without any of the form
creation or editing capabilities. 

The second program of the suite is the 'Sender' application, created in
the manner described above. The application is intended to be an easy to
use tool for office staff, that enables the  direct filling in, and
immediate transmission of forms. The application may be configured with
any number of forms and provides facilities for the  completion, 
validation and submission of the forms.  The manner in which a form is
dispatched to its intended recipient is by embedding the form data within
an eMail message. The Sender application does not send the eMail message
itself but hands over responsibility to a separate eMail application,
referred to as its eMail 'helper'. 

The third application, the 'Receiver' provides facilities for processing
received forms, ie. forms that have arrived at their destination embedded
in eMail messages.  It does not receive eMail messages itself, it instead
relies upon a separate eMail application, its eMail helper. It scans the
mailboxes of its helper recognising and reading only those messages that
contain embedded form data about which it knows, ie. for which it has been
configured. The extracted messages are then processed.  A message is
firstly scanned and the form data is extracted. The extracted data may
then, optionally be written to a database. This is achieved by handing the
data over to a separate database application, referred to as the database
'helper'. The data may also be written to a text file.  An automatic reply
may be sent and the message transferred to another mailbox.

Requirements
------------
a) System 7.5 or later. 
b) AppleScript 1.1 or later.
c) Geneva and Monaco 9 point fonts.
d) Courier 12 point

Application Helpers
-------------------
All eForm applications require the specification of an eMail Œhelper¹
application. An eMail helper is an application that is used by the host to
perform all of its eMail operations, such as sending and receiving mail.
An initialisation process involves the specification of the eMail helper
application to be used. This is done by selecting the appropriate eMail
helper library from the folder of libraries supplied with the package.
Each library contains the necessary AppleScripts to enable the host to
communicate with its eMail helper.  The Receiver application may also
optionally require the services of a database application. This too, is
provided via means of a helper library of AppleScripts. In this initial
release of the product only Eudora and FileMaker Pro are supported as
eMail and database helper applications. It is hoped to add support for
further applications as demand requires.

Eudora Light may be downloaded from the following url -
    ftp://ftp.qualcomm.com/quest/mac/eudora/1.5/eudora154.hqx

Beta Testers
------------
The package may be downloaded from the following url -
    ftp://ftp.utas.edu.au/mac/eform/eForm_1.0b4_Installer.hqx

If, after looking at the package, you would like to become a beta tester
then contact me for a free 5 form license.
    Tim Barlow      -   tim.barlow@its.utas.edu.au

-- 
Tim Barlow        tim.barlow@lib.utas.edu.au
  GPO Box 607    
  Sandy Bay
  Tasmania 7005
  Australia

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
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From: Reinhard Windoffer <reinhard.windoffer@zoologie.uni-hamburg.de>
Newsgroups: bionet.software
Subject: QE: GDE on DEC Alpha or IBM?
Date: Wed, 07 Feb 1996 16:59:24 -0800
Organization: University of Hamburg -- Germany
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Hi 

Has anybody ported GDE (Genetic Data Environment) on the DEC alpha or 
IBM?

Reinhard

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
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From: jiyun kim <jkgomdol@welchlink.welch.jhu.edu>
Newsgroups: bionet.software
Subject: DNA analysis program for PC
Date: 7 Feb 1996 21:14:18 GMT
Organization: johns hopkins university school of medicine
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Hello,

I am trying to find a PC DNA analysis that has similar features 
as mac version of DNA strider.  It would be nice if it is 
windows version.

Thanks for help.


From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
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From: mathog@seqaxp.bio.caltech.edu
Newsgroups: bionet.software
Subject: PESTFIND program available
Date: 7 Feb 1996 21:06:31 GMT
Organization: Biology Division, Caltech, Pasadena CA 91125
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Reply-To: mathog@seqaxp.bio.caltech.edu
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Interested in PEST sequences?

The PESTFIND program (from M. Rechsteiner's laboratory) has been ported
from BASICA to ANSI C.  The new version should be very portable, it is
known to compiles and run on both OpenVMS and Irix and should function on
any machine with an ANSI C compiler (provided that the compiler is actually
run in the ANSI C mode, which is not usually the default). One major
change between the BASICA and ANSI C versions - the former would process a
series of sequences in a special format.  The new one will only process one
sequence at a time, and the input file must consist of only protein
sequence (no comments, or numbers).  Both versions prompt for all needed 
information, there are no command line switches available.

Following my signature you will find:

  PESTFIND.C     ANSI C version, includes all of original program as a 
                 comment.

  PESTFIND.COM   DCL procedure for OpenVMS systems - a wrapper around
                 PESTFIND so that GCG formatted sequences and database
                 entries may be fed transparently to the program.

Please report any bugs to me or to greg_pratt@medschool.med.utah.edu (in
Rechsteiner's lab).

David Mathog
mathog@seqaxp.bio.caltech.edu
Manager, sequence analysis facility, biology division, Caltech 
****pestfind.c********************************************************
/*pestfind.c
  1-NOV-1995, David Mathog, Biology Division, Caltech

  Find PEST sequences from a single protein sequence.

  REQUIRED Input format for sequence:  plain sequence on one or more lines.  No
  numbers or spaces should be present.  Sequences longer than 10000 amino
  acids will not run correctly. A terminal "*" is allowed, but not required.
  The only allowed Amino Acid designations are: ARNDCQEGHILKMFPSTWYV
  Ambiguous residues, such as 'X' will cause the program to abort.

  This is an ANSI C version, translated from the original Basic program
  provided by Martin Rechsteiner, and incorporating the corrections 
  provided to him by Bob Stellwagen.  It should be quite portable.
  (It compiles without errors or warnings in DECC 4.1 for /standard=ansi89
  and /standard=portable.)

  Compilation/Use  on OpenVMS:
    $ cc/standard=ansi89/prefix=all pestfind
    $ link pestfind 
    $ run pestfind

  Compilation/Use  on Unix (Irix 5.3, anyway):
    $ cc -xansi -o pestfind pestfind.c
    % pestfind

  For reference purposes, here is the original program:

1 REM PESTFIND
100 ON ERROR GOTO 485
105 CLS:WIDTH 40:KEY OFF:GOTO 330
110 CNT=0:HLD=1
115 FOR Q = HLD TO X
120 IF Q=1 THEN 130 ELSE 125
125 IF A$(Q)="R" OR A$(Q)="K" OR A$(Q)="H" THEN 130 ELSE 320
130 CNT=0: HND=Q :HLD=Q
135 FOR B = 1 TO 23 : R(B) = 0 :NEXT
140 TFD(21) = 0
145 FOR I = (Q+1) TO X
150 IF A$(I)="H" OR A$(I)="K" OR A$(I)="R" THEN 165 ELSE 155
155 CNT = CNT + 1
160 NEXT I
165 IF CNT < WS THEN 170 ELSE 175
170 HLD = I : GOTO 320
175 FOR K = HLD+1 TO I-1
180 FOR N = 1 TO 20
185 IF L$(N) = A$(K) THEN 195 ELSE 190
190 NEXT N
195 R(N)=R(N)+T(N)
200 NEXT K
205 IF R(15) = 0 OR R(4)+R(7) = 0 OR R(16)+R(17) = 0 THEN 210 ELSE 235
210 IF R$ = "N" THEN 230 ELSE 215
215 LPRINT "INVALID PEST SEQUENCE: ";N$;" ";Q;"-";I;"  (WS=";WS;")"
220 FOR B=HND TO I: LPRINT A$(B);:NEXT
225 LPRINT:LPRINT "--------------------------------------------------": LPRINT
230 HLD = I : GOTO 320
235 FOR J = 1 TO 20 : R(21)=R(21)+R(J):NEXT
240 R(22)=(((R(7)+R(15)+R(16)+R(17))-(T(7)+T(15)+T(17)))/R(21))*100
245 R(23)=(((R(4)+R(7)+R(15)+R(16)+R(17))-(T(7)+T(15)+T(17)))/R(21))*100
250 FOR J = 1 TO 20 :TFD(21) = TFD(21)+(TFD(J)*(R(J)/R(21))):NEXT
255 DSC2 = -1*((-.55*R(23))+(.5*TFD(21)))
260 IF DSC2 >0 THEN 265 ELSE 300
265 LPRINT "POTENTIAL PEST SEQUENCE: ";N$;" ";Q;"-";I;"  (WS=";WS;")"
270 FOR B= HND TO I: LPRINT A$(B);" ";:NEXT B
275 LPRINT:LPRINT:LPRINT "THE MOLE FRACTION OF PEDST IS: ";R(23)
280 LPRINT "THE HYDROPHOBICITY INDEX IS ";TFD(21)
285 LPRINT:LPRINT "THE PEST-FIND SCORE IS ";: LPRINT CHR$(14) DSC2
290 LPRINT:LPRINT CHR$(14) "POSSIBLE PEST SEQUENCE":LPRINT "-------------------------------------------------":LPRINT
295 GOTO 315
300 LPRINT "POOR PEST SEQUENCE: ";N$;" ";Q;"-";I;"  (WS=";WS;")"
305 FOR B= HND TO I: LPRINT A$(B);" ";:NEXT B
310 LPRINT:LPRINT "THE PEST-FIND SCORE IS ";: LPRINT CHR$(14) DSC2 :LPRINT "-------------------------------------------------"
315 HLD = HLD + I
320 NEXT Q
325 CLS:LPRINT:LPRINT "END PEST SEARCH OF ";N$:LPRINT:LPRINT:LPRINT: IF D$ = "P" GOTO 435 ELSE RUN
330 DIM R(24): DIM T(22):DIM TFD(23):DIM L$(23): DIM A$(1500)
335 FOR I = 1 TO 20 : READ L$(I):NEXT I
340 FOR I = 1 TO 20 : READ T(I):NEXT I
345 FOR I = 1 TO 20 : READ TFD(I):NEXT
350 PRINT "************** PEST FIND ***************":PRINT:PRINT
355 INPUT "ENTER PROTEIN NAME: ",N$
360 CLS:LOCATE 10,5:INPUT "PRINT INVALID PEST SEQUENCES";R$
365 CLS:PRINT:PRINT:INPUT "WHAT IS THE MINIMUM NUMBER OF AAs       BETWEEN POSITIVE FLANKS";WS
370 PRINT:PRINT:INPUT "ENTRY FROM SCREEN(S) OR FROM PROGRAM(P)";D$
375 IF D$="S" THEN 380 ELSE 435
380 CLS:PRINT:PRINT:PRINT"ENTER ONE LETTER AMINO ACID CODE FOR    SEQUENCE (* TO END)":PRINT:PRINT:PRINT
385 FOR X = 1 TO 1500
390 PRINT"AMINO ACID ";X;" : ";:INPUT A$(X)
395 IF A$(X)="*" THEN GOTO 405 ELSE 400
400 NEXT
405 LPRINT CHR$(14) "PEST SEARCH: ",N$
410 LPRINT "--------------------------------------------------"
415 LET X = X-1:GOTO 110
420 DATA A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y,V
425 DATA 71,156,114,115,103,128,129,57,137,113,113,128,131,147,97,87,101,186,163,99
430 DATA 63,0,10,10,70,10,10,41,13,90,82,6,64,72,29,36,38,36,32,87
435 READ N$
440 CLS:PRINT:PRINT:PRINT:PRINT:PRINT"READING ",N$
445 FOR B=1 TO 1500
450 READ A$(B)
455 IF A$(B)= "*" THEN GOTO 465 ELSE 460
460 NEXT B
465 X = B-1
470 LPRINT CHR$(14) "PEST SEARCH: ",N$
475 LPRINT "--------------------------------------------------"
480 GOTO 110
485 IF ERR=4 THEN RUN

*/
#include  <ctype.h>
#include  <stdlib.h>
#include  <stdio.h>
#ifdef __VMS
#include  <unixio.h>
#endif /* __VMS */
#include  <string.h>
int main(){

/* references to "was something" indicate the corresponding BASIC variable */

int i,j,k,n;           /* assorted loop variables */
int query;             /* loop variable, marks the beginning of a query, was q*/
int last;              /* loop variable, marks the end of a query, was i*/
int piece;             /* length of individual line read from input sequence */
int remaining;         /* bytes free in buffer for input sequence */
int seqlen;            /* length of AA sequence being searched */
int flank_dist;        /* distance between positive flanks, was WS*/
int aanum[256];        /* lookup table, aa_name -> position */
float score[20];       /* pest score, was array R() */
float sum_score;       /* score summation, was R(21) */
float weight_percent;  /* weight percent of PEDST, was R(23) */
float pf_score;        /* PESTfind score, was DSC2 */
float weight[20];      /* weight in grams of 1 mole of this amino acid, was T() */
float phobe[20];       /* normalized hydrophobicity value for this amino acid, was TFD()*/
float phobe_index;     /* hydrophobicity index, was TFD(21) */
char  invalid;         /* if 'y' then print invalid PEST sequences, else no, was N$*/
char  aa_name[20];     /* single letter name for this amino acid, was L$() */
char  sequence[10000]; /* a protein sequence in single letter code, was A$() */
char  line[1000];      /* a place to format output lines */
char  infile[1000];    /* input file name */
char  outfile[1000];   /* output file name */
FILE *ifile,*ofile;    /* file pointer for input file */

/* Initialize the arrays.  Use this long form because it's easier to
   check the value at a given position than in more compact forms.
   Note that the hydrophobicity value for tyrosine used here is 58, not
   32 as in the original program - following a correction from
   Bob Stellwagen (USC).
*/

   for(i=0;i<256;i++)aanum[i] = -1;
      
   i = 0;  aa_name[i]='A';  aanum[(int) 'A']=i;  weight[i]= 71;  phobe[i]=63;
   i = 1;  aa_name[i]='R';  aanum[(int) 'R']=i;  weight[i]=156;  phobe[i]= 0;
   i = 2;  aa_name[i]='N';  aanum[(int) 'N']=i;  weight[i]=114;  phobe[i]=10;
   i = 3;  aa_name[i]='D';  aanum[(int) 'D']=i;  weight[i]=115;  phobe[i]=10;
   i = 4;  aa_name[i]='C';  aanum[(int) 'C']=i;  weight[i]=103;  phobe[i]=70;
   i = 5;  aa_name[i]='Q';  aanum[(int) 'Q']=i;  weight[i]=128;  phobe[i]=10;
   i = 6;  aa_name[i]='E';  aanum[(int) 'E']=i;  weight[i]=129;  phobe[i]=10;
   i = 7;  aa_name[i]='G';  aanum[(int) 'G']=i;  weight[i]= 57;  phobe[i]=41;
   i = 8;  aa_name[i]='H';  aanum[(int) 'H']=i;  weight[i]=137;  phobe[i]=13;
   i = 9;  aa_name[i]='I';  aanum[(int) 'I']=i;  weight[i]=113;  phobe[i]=90;
   i =10;  aa_name[i]='L';  aanum[(int) 'L']=i;  weight[i]=113;  phobe[i]=82;
   i =11;  aa_name[i]='K';  aanum[(int) 'K']=i;  weight[i]=128;  phobe[i]= 6;
   i =12;  aa_name[i]='M';  aanum[(int) 'M']=i;  weight[i]=131;  phobe[i]=64;
   i =13;  aa_name[i]='F';  aanum[(int) 'F']=i;  weight[i]=147;  phobe[i]=72;
   i =14;  aa_name[i]='P';  aanum[(int) 'P']=i;  weight[i]= 97;  phobe[i]=29;
   i =15;  aa_name[i]='S';  aanum[(int) 'S']=i;  weight[i]= 87;  phobe[i]=36;
   i =16;  aa_name[i]='T';  aanum[(int) 'T']=i;  weight[i]=101;  phobe[i]=38;
   i =17;  aa_name[i]='W';  aanum[(int) 'W']=i;  weight[i]=186;  phobe[i]=36;
   i =18;  aa_name[i]='Y';  aanum[(int) 'Y']=i;  weight[i]=163;  phobe[i]=58;
   i =19;  aa_name[i]='V';  aanum[(int) 'V']=i;  weight[i]= 99;  phobe[i]=87;

   fprintf(stdout,"************** PEST FIND ***************\n\n\n");
   fprintf(stdout,"Enter the name of the amino acid sequence file to process: ");
   scanf("%s",&infile[0]);
   fprintf(stdout,"Enter the minimum number of AAs between positive flanks:   ");
   scanf("%d",&flank_dist);
   fprintf(stdout,"Print invalid pest sequences (y/n):                        ");
   scanf("%s",&invalid);
   invalid=tolower(invalid);
   fprintf(stdout,"Enter a name for the output file:                          ");
   scanf("%s",&outfile[0]);
   fprintf(stdout,"\n\n");

/* Read in the sequence file, if possible.
   Put an "^" on each end - that will be used to enforce the PEST
   definition that N and C termini act as begin/end for PEST sequences. */

   ofile = fopen(outfile,"w");
   if(!ofile){
      fprintf(stderr,"Fatal error: the file >%s< could not be created!\n",outfile);
      fprintf(stderr,"PESTFIND run aborted\n");
      exit(0);
      }

   ifile = fopen(infile,"r");
   if(!ifile){
      fprintf(stderr,"Fatal error: the file >%s< does not exist or is unreadable!\n"
         ,infile);
      fprintf(stderr,"PESTFIND run aborted\n");
      exit(0);
      }
   else{
      remaining=9999;
      seqlen=1;
      sequence[0]='^';
      while(fgets(&sequence[seqlen],remaining,ifile)){
         piece = strlen(&sequence[seqlen]);
         seqlen = seqlen + piece - 1;
         remaining = remaining - piece;
         }
      }
/*  Remove trailing "*" and any spaces after it, if present.  Add a
    trailing '^' to enforce the N/C rule. */
   for(i=0;i<seqlen;i++){
      if(sequence[i] == '*'){
         sequence[i]='^';
         sequence[i+1]='\0';
         seqlen = i+1;
         break;
         }
      }
      if(sequence[seqlen-1] != '^'){
         sequence[seqlen] = '^';
         seqlen++;
         }

/* Convert lower to uppper, and flag anything else wrong with this sequence*/

   for(i=0;i<seqlen;i++){
      sequence[i]=toupper(sequence[i]);
      for(j=0;j<20;j++){if(sequence[i] == aa_name[j])break;}
      if(j == 20 && i != 0 && i != seqlen-1){
         fprintf(stderr,"Fatal error: the file >%s< is invalid!\n",infile);
         fprintf(stderr,"Reason: >%c< is not in the single letter AA code\n"
                ,sequence[i]);
         fprintf(stderr,"PESTFIND run aborted\n");
         exit(0);
      }        
   }

/* Time for the actual calculation */

/* First find the beginning of the possible PEST region, defined as the
   N terminus or an R, K, or H amino acid.  The beginning will be 
   marked by the variable "query" */

   query=0;
   while(query<seqlen){
      if(  sequence[query] == '^' || 
           sequence[query] == 'R' || 
           sequence[query] == 'K' || 
           sequence[query] == 'H' ){
         }
      else{
         continue;   /* on query loop */
         }


      for(last=query+1;last<seqlen;last++){
         if(  sequence[last] == '^' || 
              sequence[last] == 'R' || 
              sequence[last] == 'K' || 
              sequence[last] == 'H')break;
         }    /*  loop on last*/

      if(last - query + 1 < flank_dist){
         query = last;
         continue;   /* to bottom of query loop*/
         }
      else{

/* initialize the accumulators */

         for(j=0;j<20;j++)score[j]=0;
         phobe_index=0;
         sum_score=0;

/* Add up occupancy * weight for each type of AA in this region*/

         for(k=query+1;k<last;k++){
            for(j=0;j<20;j++){
               if(aa_name[j] == sequence[k]){
                  score[j] = score[j] + weight[j];
                  break;
                  }
               } /* loop on j */
            }    /* loop on k */

         if(   (score[aanum[(int) 'P']] == 0)
            || (score[aanum[(int) 'D']] + score[aanum[(int) 'E']] == 0)
            || (score[aanum[(int) 'S']] + score[aanum[(int) 'T']] == 0)){
            if(invalid == 'y'){
               fprintf(ofile,"Invalid PEST sequence %d-%d (flank_dist=%d)\n",
                       query,last,last-query-1);
               strncpy(line,&sequence[query],last-query+1);
               line[last-query+1] = '\0';
               fprintf(ofile,"%s\n",line);
               fprintf(ofile,"---------------------------------\n\n");
               }
	    query = last;
            continue;  /* to the bottom of the query loop*/
            }
         else{
	    for(j=0;j<20;j++)sum_score=sum_score + score[j];
            weight_percent =(100.0 / sum_score) *
                      (( score[aanum[(int) 'D']]   + 
                         score[aanum[(int) 'E']]   +
                         score[aanum[(int) 'T']]   +
                         score[aanum[(int) 'S']]   +
                         score[aanum[(int) 'P']] )
                                       -
                       ( weight[aanum[(int) 'E']] +
                         weight[aanum[(int) 'P']] +
                         weight[aanum[(int) 'T']] ));

/* Presumably the original point of subtracting these was to remove them
because they were required, ie, there must have been a P, E/D or S/T to
have reached this point.  Still, it should really check for E vs. D or S
vs. T and subtracted the right one! Similarly, the three required ones
should not go into sum_score, but they do, which artificially lowers the
weight percent value.  But doing any of this would change the values 
reported by the C version relative to the Basic version.*/ 

	    for(j=0;j<20;j++)phobe_index = phobe_index +
                        (phobe[j] * score[j] / sum_score);
            pf_score = (0.55 * weight_percent) - (0.5 * phobe_index);
            if(pf_score > 0){
               fprintf(ofile,"Potential PEST sequence %d-%d (flank_dist=%d)\n",
                       query,last,last-query-1);
               strncpy(line,&sequence[query],last-query+1);
               line[last-query+1] = '\0';
               fprintf(ofile,"  %s\n",line);
               fprintf(ofile,"  The weight percent of PEDST is: %f\n",weight_percent);
               fprintf(ofile,"  The hydrophobicity index is: %f\n",phobe_index);
               fprintf(ofile,"  The PEST-FIND score is: %f\n",pf_score);
               fprintf(ofile,"---------------------------------\n\n");
               }
            else {
               fprintf(ofile,"Poor PEST sequence %d-%d (flank_dist=%d)\n",
                       query,last,last-query-1);
               strncpy(line,&sequence[query],last-query+1);
               line[last-query+1] = '\0';
               fprintf(ofile,"  %s\n",line);
               fprintf(ofile,"  The best PEST-FIND score is: %f\n",pf_score);
               fprintf(ofile,"---------------------------------\n\n");
               }
            query = last;
            continue;  /* to bottom of query loop */
            }
         query++;
         }
      }          /* loop on query */
      fprintf(stderr,"PESTFIND run completed normally\n");
}
****pestfind.com******************************************************
$!Pestfind.com
$! 4-NOV-1995, David Mathog, biology division, Caltech
$!
$! This procedure is a wrapper for the actual PestFind program, it
$! allows it to act on one or more GCG formatted files.
$! This uses the TOSEQ program, if you don't have that, you may
$! have the EGCG TOTEXT, which does the same thing.  This wrapper isn't
$! terribly robust, so files of file names must consist of ONLY entries
$! and filenames; comments,"..", stuff after the filename, etc, any of these
$! will break this procedure!!!
$!
$! All files are processed with a window of 9 and no invalid PEST sequences.
$!
$! A logical PESTFIND must point to the location of the PESTFIND program
$!
$! invoke with 
$!
$! @pestfind filename        (either a file or a GCG entry)
$!       or
$! @pestfind @filename       (a file of file names)
$!
$!
$ if(P1 .eqs. "")
$ then
$   type sys$input

    Find PEST sequences in proteins.


    This will accept as input one of:

    1.  The name of a GCG formatted peptide file:         filename.pep
    2.  The name of a GCG peptide database entry:         sw:1433_HORVU
    3.  A GCG file of filenames (containing either
        of the above but nothing else)                    @filelist.fil

Note 1:  If any sequence contains an ambiguous residue, such as B,X, or Z,
         pestfind will not process that sequence.  It will issue an error
         message and stop.

Note 2:  Default Parameters:  minimum pest sequence (window) size =9
                              no invalid PEST sequences shown
                              outfile = pestfind.out

         To change one or more of thse parameters, hit a ^Y NOW and issue
         one or more of these commands before running PESTFIND again:

         $ pestfind_window  :== 10         (or whatever value you want)
         $ pestfind_invalid :==  Y         (to see invalid ones) 
         $ pestfind_out     :==  filename  (valid VMS filename) 
       
$   inquire acton "Enter file, entry, or file of filenames = "
$ else
$    acton = P1
$ endif
$!
$! make up a root for temporary file names
$!
$ now = f$time()
$ username = f$getjpi("","USERNAME")
$ username = f$edit(username,"COLLAPSE")
$ tempname = "kill_" + username + "_" -
              + f$cvtime(now,,"MONTH") -
              + f$cvtime(now,,"DAY") -
              + f$cvtime(now,,"HOUR") -
              + f$cvtime(now,,"MINUTE") -
              + f$cvtime(now,,"HUNDREDTH")
$!
$! does it begin with an "@"?
$!
$ on control_c then goto
$ if(f$extract(0,1,acton) .eqs. "@")
$ then
$   loop = 1
$   namelen = f$length(acton) - 1
$   open/read/error=oops tfil: 'f$extract(1,namelen,acton)
$   read tfil: file
$ else
$   loop = 0
$   file = acton
$ endif
$!
$!
$ if("''pestfind_window'" .nes. "")
$ then
$   window = pestfind_window
$ else
$   window = 9
$ endif
$!
$ if("''pestfind_invalid'" .nes. "Y")
$ then
$   invalid = "N"
$ else
$   invalid = "Y"
$ endif
$!
$ if("''pestfind_out'" .nes. "")
$ then
$   pout  = pestfind_out
$ else
$   pout := pestfind.out
$ endif
$!
$open/write rfil: 'tempname'.accum
$write rfil: "Pestfind analysis of ''acton'"
$write rfil: "Processing began at ''now'"
$write rfil: " "
$write rfil: "Results on:  ''file'"
$write rfil: "===================================================="
$close rfil:
$!
$  on error then goto oops
$top:
$  write sys$output "Now processing:  ''file'"
$  toseq/infile='file'/out='tempname'.pep/line=50/protein/default
$  open/write cfil: 'tempname'.com
$  write cfil: "define/user sys$output nla0:"
$  write cfil: "define/user sys$error  ''tempname'.error"
$  write cfil: "$run pestfind:pestfind"
$  write cfil: "''tempname'.pep"
$  write cfil: window
$  write cfil: invalid
$  write cfil: "''tempname'.tmp"
$  close cfil:
$  @'tempname'.com
$  define/user sys$output nla0:
$  define/user sys$error  nla0:
$  search 'tempname'.error "PESTFIND run completed normally"
$  if($STATUS .ne. 1)
$  then
$!
$!    error during run, put the error message in instead
$!
$     convert/fdl=sys$input 'tempname'.error 'tempname'.tmp2 
RECORD
        BLOCK_SPAN              yes
        CARRIAGE_CONTROL        print
        FORMAT                  vfc
        SIZE                    0
        CONTROL_FIELD_SIZE      2
$  else
$!
$! Run completed ok, so tack the results on
$!
$! Convert file type so that append will work properly.  streamlf
$! strikes again :-(.
$!
$     convert/fdl=sys$input 'tempname'.tmp 'tempname'.tmp2 
RECORD
        BLOCK_SPAN              yes
        CARRIAGE_CONTROL        print
        FORMAT                  vfc
        SIZE                    0
        CONTROL_FIELD_SIZE      2
$  endif
$  append 'tempname'.tmp2 'tempname'.accum
$  delete 'tempname'.tmp2;
$  delete 'tempname'.error;
$  delete 'tempname'.pep;
$  delete 'tempname'.com;
$  delete 'tempname'.tmp;
$  if(loop .eq. 1)
$  then
$     read/end=done tfil: file
$     open/append rfil: 'tempname'.accum
$     write rfil: "Results on:  ''file'"
$     write rfil: "===================================================="
$     close rfil:
$     goto top
$  endif
$  goto cleanup
$!
$done:
$  close tfil:
$!
$cleanup:
$  rename 'tempname'.accum 'pout'
$  write sys$output "Run completed, results are in ''pout'"
$  exit
$!
$oops:
$  write sys$output "--------------------------"
$  write sys$output "FATAL ERROR!!!!!"
$  write sys$output "something went wrong when processing ''acton'"
$  if(loop .eq. 1)then close tfil:
$  exit
$oops2:
$  write sys$output "--------------------------"
$  write sys$output "Run aborted by ^C or ^Y"
$  delete 'tempname'.*.*
$  exit

From owner-software@net.bio.net Tue Feb 06 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!howland.reston.ans.net!plug.news.pipex.net!pipex!tube.news.pipex.net!pipex!lade.news.pipex.net!pipex!news.ftech.net!news
From: psiber@ftech.co.uk (Alan)
Newsgroups: bionet.software
Subject: Re: [Q]:?how to run MAC SW on PC (Windows95)
Date: Wed, 07 Feb 1996 02:24:26 GMT
Organization: Visionaries.co.uk
Lines: 39
Message-ID: <4f92f5$ku0@alpha.ftech.net>
References: <4eprqm$kes@mserv1.dl.ac.uk> <31114385.41C6@rhapsody.stanford.edu>
Reply-To: psiber@ftech.co.uk
NNTP-Posting-Host: psiber.ftech.co.uk
X-Newsreader: Forte Free Agent 1.0.82

Hi, I'm Alan

Sorry to butt in likr this, but there is something of great interest
to me here.

Lionel Gilet <gilet@rhapsody.stanford.edu> wrote:

>I did that once. The Mac software was written in object-oriented c/c++
>with Symantec librairies. It was basicallly reading a file generated by
>Excell, doing some calculation and displaying a bunch of graphic windows with
>a floating window that would display the coordinates of the point you click
>on.

So my question is, does anyone here now of some shareware or freeware
that can map coordnates clicked into a plain text file?

This is, I know completely irrelevant to this thread, but I guessed
that some peple in this field may have had use for such a tool at some
time.

Greateful if anyone can help.

Alan

By the way, I'm mapping bitmapped celtic knots to vector's for
raytracing. I'll need something to smooth the lines of my shaky hand
too!


Visionaries T-shirts & Gifts London: Don't miss it @ http://www.visionaries.co.uk/
or visit The Hotlist  http://www.visionaries.co.uk/zine/hots/hotindex.hts#index
|\         .-.
| \       /   \       .-.     .-.     _   
+--\--p--/--s--\--i--/-b-\-e-/-r-\---/-\---
|   \   /       \   /     '-'     '-'
|    '-'         '-'

Email:               psiber@ftech.co.uk


From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!plug.news.pipex.net!pipex!tube.news.pipex.net!pipex!lade.news.pipex.net!pipex!news.ftech.net!news
From: psiber@ftech.co.uk (Alan)
Newsgroups: bionet.software
Subject: Re: SOFTER WEAR!!!!
Date: Thu, 08 Feb 1996 00:45:07 GMT
Organization: Visionaries.co.uk
Lines: 32
Message-ID: <4fbh0p$v4q@alpha.ftech.net>
References: <islpub-0602961933370001@islpub.vnet.net>
Reply-To: psiber@ftech.co.uk
NNTP-Posting-Host: psiber.ftech.co.uk
X-Newsreader: Forte Free Agent 1.0.82

islpub@vnet.com (TeeMo) wrote:

>You're gonna be GLAD you been HAD, when you visit this site!

I have to say, that I wasn't impressed

>Sysop Softwear!
Softop Syswear?

>T-Shirts€ T-Shirts€T-Shirts€ T-Shirts€ T-Shirts€ T-Shirts€ 

>Questions?:   islpub@vnet.net

Yes. What have T-shirts to do with bionet software?

BTW thanks to all posters. This group is highly informative, relaxed,
and a pleasure to read!

Alan




Visionaries T-shirts & Gifts London: http://www.visionaries.co.uk/
The Hotlists                         http://www.visionaries.co.uk/zine/hots/hotindex.hts#index
|\         .-.
| \       /   \       .-.     .-.     _   
+--\--p--/--s--\--i--/-b-\-e-/-r-\---/-\---
|   \   /       \   /     '-'     '-'
|    '-'         '-'
Email:               psiber@ftech.co.uk


From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!plug.news.pipex.net!pipex!tube.news.pipex.net!pipex!lade.news.pipex.net!pipex!news.ftech.net!news
From: psiber@ftech.co.uk (Alan)
Newsgroups: bionet.software
Subject: Re: Need help running WIN.95-help!!!
Date: Thu, 08 Feb 1996 00:45:10 GMT
Organization: Visionaries.co.uk
Lines: 42
Message-ID: <4fbh0t$v4q@alpha.ftech.net>
References: <4f9kml$n36@coranto.ucs.mun.ca>
Reply-To: psiber@ftech.co.uk
NNTP-Posting-Host: psiber.ftech.co.uk
X-Newsreader: Forte Free Agent 1.0.82

I think that if youread a little closer, you may see that the message
actually says something about

A system device or driver _Reffered to in_ the registry or system.ini
cannot be found.

Read the name of the offending file (proably something.drv .dll .386
or .vxd.

Locate this file!

If it is not on your disk/bin you must remove the offending
system.ini, or registry entry.

This may or may not affect some installed software. The reg or ini
entry should indicate the program that wants to find or use the
missing file.

You may have deleted the main program but not fully cleaned your
system's references to it.

Good Luck.

let me know if you have problems.


username@terra.nlnet.nf.ca (Full name) wrote:

>I recently downloaded some files needed to finish installing the net.
>Now when I start my computer I get a message saying that a windows registary
>or System ini.file can no longer be found.
>If by mistake, I erased this file, how can I get it back?
> ps. I tried installing win.95 again with same results.
>     And also not in the Recycle Bin.
>            NEED HELP

"..my God..*. it's full of stars...*..*.............*.
...*....*....* http://www.visionaries.co.uk/ ........
*..*.Raylist * .........*..Add......*Your..*....Link....*.*.
**.. http://www.visionaries.co.uk/zine/hots/hotrays.hts .*
Email: *...*......*...  psiber@ftech.co.uk  ..*...*.*.


From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Newsgroups: bionet.software
Path: biosci!bloom-beacon.mit.edu!newsfeed.internetmci.com!primus.ac.net!news.cais.net!xara.net!peer-news.britain.eu.net!liv!news
From: P.W.Gould@liverpool.ac.uk (Paul Gould)
Subject: Re: Biology Education Software FAQ
Message-ID: <DMGHuB.GDs@liverpool.ac.uk>
Sender: news@liverpool.ac.uk (News System)
Nntp-Posting-Host: ctibiol2.bioc.liv.ac.uk
Organization: The University of Liverpool
X-Newsreader: RadicalNews (TM) v0.8.1 Beta
References: <4ep0h8$lqn@nntp3.u.washington.edu> <4f0cs8$k7p@bbs.dordt.edu> 
	<4f6l11$aom@metro.usyd.edu.au> 
Distribution: inet
Date: Thu, 8 Feb 1996 12:10:58 GMT
Lines: 21

In <4f6l11$aom@metro.usyd.edu.au> Dianne Chambers wrote:
> I am part of UniServe*Science which is an Australian  group whose role
> includes finding and evaluating software packages that could be used in
> undergraduate science teaching.  I look after biology, biochemistry,
> and psychology.

A third alternative is the CTI Biology Resource Directory, which is
available from our home page at <URL:http://www.liv.ac.uk/ctibiol.html>.
This is in the process of being updated, and holds information on a wide
range of courseware, videodiscs, books etc. useful for teaching biology at
university level.

Regards,

Paul 
--
Paul Gould, Network Support Officer               +44 151-794 5118 (Tel)
CTI Biology, Donnan Laboratories                  +44 151-794 4401 (Fax)
University of Liverpool, PO Box 147               P.W.Gould@liv.ac.uk
Liverpool L69 3BX, UK                             (MIME/NeXTmail OK)


From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!tank.news.pipex.net!pipex!peer-news.britain.eu.net!lyra.csx.cam.ac.uk!warwick!news.nott.ac.uk!griffin.nott.ac.uk!wpbfd.biochem.nottingham.ac.uk!user
From: mbxfd@unix.ccc.nottingham.ac.uk (Fergus Doherty)
Newsgroups: bionet.software
Subject: Intracellular calcium movies?
Followup-To: bionet.software
Date: 5 Feb 1996 17:36:27 GMT
Organization: Nottingham University, UK.
Lines: 11
Distribution: world
Message-ID: <mbxfd-050296175322@wpbfd.biochem.nottingham.ac.uk>
NNTP-Posting-Host: wpbfd.biochem.nottingham.ac.uk

Does anyone know of any QuickTime or MPEG movies showing intracellular
calcium changes in response to ligand binding?  Is their anything on the
WWW I can download.  I can translate Video for Windows to QT if necessary.

Fergus Doherty,
dept. Biochemistry,
University Medical School,
Queen's Medical Centre,
Nottingham NG7 2UH
Tel: (0)115 970 9366  FAX (0)115 942 2225 Internet:
Fergus.Doherty@nottingham.ac.uk

From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!vixen.cso.uiuc.edu!howland.reston.ans.net!nntp.coast.net!torn!news.ccs.queensu.ca!news
From: "Eric B. Carstens" <carstens@post.queensu.ca>
Newsgroups: bionet.software
Subject: Re: GCK
Date: Thu, 08 Feb 1996 09:59:05 +0000
Organization: Queen's University
Lines: 5
Message-ID: <3119C969.3F7C@post.queensu.ca>
References: <3115CA70.2F64@cell.biol.ethz.ch>
NNTP-Posting-Host: u133.n148.queensu.ca
Mime-Version: 1.0
Content-Type: text/plain; charset=us-ascii
Content-Transfer-Encoding: 7bit
X-Mailer: Mozilla 2.0 (Macintosh; I; 68K)

We have been using GCK for a number of years now. It has proven very 
useful in a number of different ways. We especially like cloning by 
computer so that predictions about REN sites, size of fragments, etc 
can be easily made. The parent company Textco has also proven to be 
very helpful and continues to support the program with free updates.

From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!DALI.MATHEMATIK.UNI-BIELEFELD.DE!fuellen
From: fuellen@DALI.MATHEMATIK.UNI-BIELEFELD.DE (Georg Fuellen)
Newsgroups: bionet.software
Subject: Join the Bioperl Development List Now !
Date: 8 Feb 1996 08:19:03 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 32
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <9602081615.AA13606@dali.Mathematik.Uni-Bielefeld.DE>
NNTP-Posting-Host: net.bio.net

Dear fellow Bionetters,

The Bioperl Development List has been established recently, to coordinate
development of a set of modules to manage molecular biology information
in Perl.

A few days ago, a proposal for Perl5 Objects for Sequences, Alignments, and
Phylogenies has been posted to the list, and we hope to get discussion going
really soon. The more feedback you provide now, the better Bioperl modules
can serve you at a future date ! The URL of the proposal is
http://www.techfak.uni-bielefeld.de/bcd/Tec/Bioperl/welcome.html

To join the Bioperl Development List, send a "subscribe BIOPERL" message to
bioperl-request@mole.bio.cam.ac.uk
You will be sent further information, and instructions on how you can
unsubscribe. The URL of the list is http://scop.mrc-lmb.cam.ac.uk/pub/bioperl/

About Perl: Perl5 (a significant improvement of former Perl versions) is
a high-level scripting language with facilities for modular,
object-oriented programming; productivity gains can be significant without
compromising high standards in maintainabilty and readabilty. Applications
that require very high speed can be integrated from a C library;
a Perl compiler is under development.

-----------
best wishes,
  georg
fuellen@dali.Mathematik.Uni-Bielefeld.DE, fuellen@MIT.EDU
  http://www.techfak.uni-bielefeld.de/techfak/persons/fuellen/georgF.html




From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!daresbury!not-for-mail
From: Alexy Eroshkin <eroshkin@vector.nsk.su>
Newsgroups: bionet.software
Subject: ANNOUCING PRANA - NEW PROTEIN STRUCTURE-ACTIVITY ANALYSIS SOFTWARE
Date: 8 Feb 1996 11:50:48 -0000
Organization: State Research Center of Virology & Biotechnology VECTOR
Lines: 100
Sender: lpddist@mserv1.dl.ac.uk
Distribution: bionet
Message-ID: <4fco2o$f2a@mserv1.dl.ac.uk>
Original-To: bio-software@dl.ac.uk

To:  bio-software@dl.ac.uk
From:  eroshkin@vector.nsk.su <Alexey Eroshkin>
Subject: ANNOUNCING PRANA - NEW PROTEIN STRUCTURE-ACTIVITY ANALYSIS SOFTWARE


-------------------------------------------------------------------
 PRANA : PC-based program for studying the relationships between
     structure and activity in protein/peptide families
-------------------------------------------------------------------
                         by
          I.Pika, V.Ivanisenko & A.Eroshkin

State Research Center of Virology and Biotechnology "Vector" Koltsovo,
           Novosibirsk Region, 633159 Russia

    E.mail: eroshkin@vector.nsk.su, Tel: +7 (3832) - 647774,
                Fax: +7 (3832) - 328831
-------------------------------------------------------------------

The State Research Center of Virology and Biotechnology "VECTOR" is
pleased to announce the availability of PRANA v1.0.
PRANA is an easy-to-use, state-of-the-art MSDOS application for studying
the relationships between structure and activity in protein/peptide
families divided in two groups (by activity, property, evolution, etc.).
The program examines the relationships between protein grouping and
physico-chemical characteristics (e.g., mean Hydrophobicity, Charge, or
Volume, alpha-helical or beta-strand moments of Hydrophobicity, etc.) of
different regions in their primary structures and delineates the sites
and characteristics describing the given grouping.

PRANA is based on the program PROANAL (A. Eroshkin, V.Fomin, P.Zhilkin,
CABIOS, 1993, 9, 491-497) and designed to provide analysis of additional
data. PROANAL looks for correlations between quantitative data on
protein activity and physico-chemical characteristics of the regions in
the primary structures. In case of PRANA the analysis is based on
aligned amino acid sequences and data on protein grouping (qualitative
activity data). The program searches activity-modulating regions in
aligned proteins that have different structure characteristics for two
groups (biophore or pharmacophore).  Student's or Kolmogorov - Smirnov's
criteria are used to compare the distributions of the characteristics in
two protein groups. The results - found sites and their physico-chemical
characteristics as well as all necessary statistical evaluations - are
presented in the form of text and histograms that can be saved or
printed as required.

PRANA CAN BE USED:

- to find sites and site characteristics that may be responsible for
the difference in proteins activity or property;

- to classify newly sequenced proteins/peptides;

- to assist in simulation of protein engineering experiments.

EXAMPLES OF DATA TYPES TO BE ANALYZED

- 15 variants of human alpha-interferons can be divided into two groups
of high and low antiviral activity. The task is to find amino
acid residues in IFN-alpha related with this difference in activity;

- influenza A virus M(2) proteins from virus strain resistant or
sensitive to amantadine. The task: to find amino acid residues in M(2)
involved in amantadine binding and amino acid physico-chemical
properties important for this interaction.

- peptides inserted into VP1 protein of poliovirus type 1.  Some of
mutant viruses were viable, other - not. The task: to find the
physico-chemical characteristics of the peptide inserts, that are
important for mutant virus viability.


PRANA HAS

* converter from SWISS-PROT, CLUSTAL, GCG, PHYLIP formats to PRANA
  input files;
* data files with about 100 amino acid physico-chemical properties;
* examples, manual and help system.

REQUIREMENTS: DOS 3.30 or later, EGA/VGA video card, 400 KB RAM.

PRANA AVAILABILITY

PRANA v1.0 is freely available for academic users through EBI ftp
server ftp.ebi.ac.uk  (directory  /pub/software/dos/prana).
For companies inquire to:

Alexey Eroshkin
SRC VB "Vector"
Koltsovo, Novosibirsk Region
633159 Russia
E.mail: eroshkin@vector.nsk.su
Tel: +7 (3832) - 647774
Fax: +7 (3832) - 328831


PRANA USERS

Don't hesitate to contact us in case of problems, bugs or suggestions.
Could you send us your address (Email is preferred) and your feelings about
your PRANA experience?

From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!info.ucla.edu!news.ucdavis.edu!quad!knight
From: knight@quad.cs.ucdavis.edu (James Knight)
Newsgroups: bionet.software
Subject: ANNOUNCE:  SEQIO - A C Package for Reading and Writing Sequences
Date: 8 Feb 1996 03:09:24 GMT
Organization: University of California, Davis
Lines: 88
Message-ID: <4fbph4$31@mark.ucdavis.edu>
NNTP-Posting-Host: quad.cs.ucdavis.edu
X-Newsreader: TIN [version 1.2 PL2]


This is the initial release of the SEQIO package, a set of C functions
which can read and write biological sequence files formatted using
various file formats and which can be used to perform efficient
database searches on biological databases.  It's essentially a
successor to the "readseq" program, but geared more toward being used
in programs than just as a file conversion program (although it can do
that too.

The package currently supports the following file formats: GenBank
Flat File, PIR/CODATA, EMBL/Swiss-Prot, FASTA, NBRF, IG/Stanford,
ASN.1 text files.  More formats will be included as I can find out the
details about them.

The package is freely available to anyone and can be ftp'ed from the
following FTP site:

   ftp://ftp.cs.ucdavis.edu/pub/strings/seqio.tar.gz

It is a gzip'ed, tar file containing the package code and
documentation files.  I don't have a Web site up yet, but it's coming
soon.


What I'm looking for now are four things, 

    1) Users to begin writing programs with the package (see below
       for an example program).
    2) People who have examples and/or descriptions of other file
       formats so I can include them (it takes me on average about
       a hour per file format).  High on my list of formats to
       include are the Phylip formats, FASTA/BLAST output and any
       multiple sequence alignment formats.  A more complete list
       is given in the documentation.
    3) Information about the organization and file formats used
       by any databases out there (if you look at the documentation
       to the package, you'll see what I mean).
    4) Folks who are interested enough in getting the package to
       run on their machine that they would help me port it.  It
       currently is Unix-specific software and has been tested under
       SunOS, Ultrix and IRIX, because they are the only machines
       I have access to.  I'm willing to do as much as I can to
       get it to work on any and all machines.


The main goal of the package was to make reading and writing sequences
as easy as reading and writing normal files, as well as being able to
handle large databases like GenBank.  As an example, this complete
program takes a keyword and database name, checks all of the sequences
in the database and outputs the entries whose sequences match a keyword:

#include <stdio.h>
#include <stdlib.h>
#include "seqio.h"

int main(int argc, char *argv[])
{
  int len;
  char *seq, *entry;
  SEQFILE *sfp;

  if (argc != 3) {
    fprintf(stderr, "match keyword database\n");
    exit(1);
  }

  if ((sfp = seqfopendb(argv[2])) == NULL)
    exit(1);

  while ((seq = seqfgetseq(sfp, &len, 0)) != NULL) {
    if (len > 0 && strstr(seq, argv[1])) {
      entry = seqfentry(sfp, NULL, 0);
      fputs(entry, stdout);
    }
  }

  seqfclose(sfp);
  return 0;
}

This program scanned all of the GenBank database, Flat File Release
87.0 (about 800MB characters, 249MB of sequence), for a randomly
generated 20 character sequence in under 8 minutes on a DEC 5000/240
(not an Alpha).





From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.uoregon.edu!news.rediris.es!news.belnet.be!news.fundp.ac.be!st10.info.fundp.ac.be!van
From: van@info.fundp.ac.be
Newsgroups: bionet.software
Subject: Help. I need a driver for my scanner
Date: Thu, 8 Feb 1996 14:42:39
Organization: Institut d'Informatique (FUNDP - Namur), Belgium
Lines: 6
Message-ID: <van.4.000EB66D@info.fundp.ac.be>
NNTP-Posting-Host: st10.info.fundp.ac.be
Summary: Help. I need a driver for my scanner
Keywords: scanner
X-Newsreader: Trumpet for Windows [Version 1.0 Rev A]

Does anyone have a driver for a Proscan 256 Gray scale scanner
model PS-4001G  ?

If not, where could I get it ?
Thanks in advance


From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!netnews.nwnet.net!mule.fhcrc.org!hal-quadra.fhcrc.org!user
From: dturner@fred.fhcrc.org (Dave Turner)
Newsgroups: bionet.software
Subject: Re: DNA Alignment Software
Date: 8 Feb 1996 19:53:35 GMT
Organization: FHCRC
Lines: 14
Message-ID: <dturner-0802961153550001@hal-quadra.fhcrc.org>
References: <yasuhito-2901961658480001@surg2_111.m.ehime-u.ac.jp> <hardy-3101961022450001@mighty.facs.fccc.edu>
NNTP-Posting-Host: hal-quadra.fhcrc.org
X-Newsreader: Yet Another NewsWatcher 2.1.2



 In article <yasuhito-2901961658480001@surg2_111.m.ehime-u.ac.jp>,
 yasuhito@m.ehime-u.ac.jp (Yasuhito Abe) wrote:
 
 >Dear Netters,
 >I would like to get information on the alignment software for DNA
 >using MacOS.  Would someone please tell me the best ones?
 >Of course, I prefer free ones.

Another NOT FREE program is DNASTAR  About 1 1/2 years ago I reveiwaed all
the commercial packages and DNASTAR  had the best multiple sequence
alignment (by far).  It has great options for displaying the alignments
and highlighting what you want.  Unfortunately it is not cheep.

From owner-software@net.bio.net Wed Feb 07 22:00:00 1996
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!elroy.jpl.nasa.gov!swrinde!newsfeed.internetmci.com!vixen.cso.uiuc.edu!milo.mcs.anl.gov!jadoube.mcs.anl.gov!levine
From: levine@jadoube.mcs.anl.gov (David Levine)
Newsgroups: bionet.software
Subject: PGAPack V1.0, Parallel GA Software
Date: Thu, 8 Feb 1996 18:7:58 GMT
Organization: Math and Computer Science, Argonne National Laboratory
Lines: 27
Distribution: world
Message-ID: <82380287821309@jadoube.mcs.anl.gov>
NNTP-Posting-Host: jadoube.mcs.anl.gov

The following freely-distributed software is now available...

PGAPack is a general-purpose, data-structure-neutral, parallel genetic
algorithm library.  It is intended to provide most capabilities desired in a
genetic algorithm library, in an integrated, seamless, and portable manner.
Key features include:

* Callable from Fortran or C.
* Runs on uniprocessors, parallel computers, and workstation networks.
* Binary-, integer-, real-, and character-valued native data types.
* Full extensibility to support custom operators and new data types.
* Easy-to-use interface for novice and application users.
* Multiple levels of access for expert users.
* Parameterized population replacement.
* Multiple crossover, mutation, and selection operators
* Easy integration of hill-climbing heuristics. 
* Extensive debugging facilities.
* Large set of example problems.
* Detailed users guide

PGAPack is available:
  -- via anonymous ftp from ftp.mcs.anl.gov in file pub/pgapack/pgapack.tar.Z
  -- via the web at http://www.mcs.anl.gov/pgapack.html 

David Levine     levine@mcs.anl.gov      http://www.mcs.anl.gov/home/levine
MCS 221 C-216    Argonne National Laboratory   Argonne, Illinois 60439
(708)-252-6735   Fax: (708)-252-5986

From owner-software@net.bio.net Thu Feb 08 22:00:00 1996
Path: biosci!news.Stanford.EDU!nntp-hub2.barrnet.net!news1.digital.com!ames!usenet.kornet.nm.kr!news.kreonet.re.kr!news.dacom.co.kr!nntp.coast.net!howland.reston.ans.net!ix.netcom.com!netnews
From: rcq@ix.netcom.com(RONALDO QUISPE )
Newsgroups: bionet.software
Subject: 3-D molecule representation software NEEDED
Date: 9 Feb 1996 02:42:15 GMT
Organization: Netcom
Lines: 11
Message-ID: <4feca7$cnu@reader2.ix.netcom.com>
NNTP-Posting-Host: ix-pat3-16.ix.netcom.com
X-NETCOM-Date: Thu Feb 08  6:42:16 PM PST 1996


 Hello,

    I need software that can represent molecules in a 3-D format. I
need to be able to modify and create other molecules. I have seen CAD
programs that can do this but are rather expensive. Anything out there
at a reasonable price?

                                                Ron Q.

    E-mail: rcq@ix.netcom.com

From owner-software@net.bio.net Thu Feb 08 22:00:00 1996
Path: biosci!bcm.tmc.edu!newshost.convex.com!news.duke.edu!news.mathworks.com!news.kei.com!nntp.coast.net!harbinger.cc.monash.edu.au!news.bhp.com.au!mel.dit.csiro.au!actcsiro!news
From: m.ballard@chem.csiro.au (Mat Ballard)
Newsgroups: bionet.software,