From owner-software@net.bio.net Mon Sep 01 23:00:00 1997
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From: "SPECIAL !!!" special@email-now4.com
Newsgroups: bionet.software
Subject: S O F T W A R E  ==>> 9 0  %   O F F <<==
Date: Tue, 02 Sep 1997 01:14:47 -0700
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<<<<<<<  COMPUTER SOFTWARE / HARDWARE  >>>>>>>

                            >>> UP  TO  90 % OFF <<<

                  http://www.quantcom.com/auctionfirst/>=<<=<<==<<>>=>>=>=>

From owner-software@net.bio.net Mon Sep 01 23:00:00 1997
Path: biosci!ACSU.BUFFALO.EDU!mczhang
From: mczhang@ACSU.BUFFALO.EDU (Manchao Zhang)
Newsgroups: bionet.software
Subject: cytotoxicity software needed!!!
Date: 2 Sep 1997 06:36:59 -0700
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Dear Netters,

   We have lots of NK cell data to caculate lytic units (LU), dose anybody
help us to recommend some software? Thank you very much!

  M.Zhang
  Dept Pathol
  SUNY at Buffalo
  e-mail: mczhang@acsu.buffalo.edu 


From owner-software@net.bio.net Mon Sep 01 23:00:00 1997
Path: biosci!agate!ihnp4.ucsd.edu!gondor!newshub.sdsu.edu!newshub.csu.net!csulb.edu!logbridge.uoregon.edu!newsfeed1-hme1!newsfeed.internetmci.com!166.93.8.12!natasha.rmii.com!news1.rmi.net!not-for-mail
From: richard_steinman@cmagroup.com
Newsgroups: bionet.software
Subject: USA-CO; Boulder/Longmont; Software Engineer; C++, Signal Processing
Date: 2 Sep 1997 23:25:11 GMT
Organization: Career Marketing Associates
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USA-CO; Boulder/Longmont; Software Engineer; C++, Signal Processing

C, C++ programmer, signal processing, Windows/NT, GUI, convert low level 
Bio signals into data for PC presentaation. Brain waves, EEG, humans and 
animals. Real-time data acquisition. Nerve impulse recording. Would like 
lab experience-data analysis and reduction, familiar with instrumentation. 
New grad to 3 years experience. Small company-software engineers get the 
whole enchillada not just a small piece. Needs to be hungry and eager 
to learn. Really need C++, MFC, WIN32, Windows NT, 95 as well as somewhat 
of a scientific or engineering background. 

Please refer to JO# 2431JMS in your response.



Richard Steinman
Team Leader
rjs@cmagroup.com
IT & Software Solutions Team
Career Marketing Associates
http://www.cmagroup.com/IT.html

From owner-software@net.bio.net Mon Sep 01 23:00:00 1997
Path: biosci!VUB.VUB.AC.BE!kdesmet
From: kdesmet@VUB.VUB.AC.BE (Karen De Smet)
Newsgroups: bionet.software
Subject: toxicology.software
Date: 2 Sep 1997 05:25:44 -0700
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Hello everybody,

We are looking for any software-package (PC or Macintosh) to be used 
in practical course of Toxicology for pharmacy students (4th grade). 
Does this exist at all??? If it does, where could we get this? 

Thank you very much,

Karen & Sonja

From owner-software@net.bio.net Tue Sep 02 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!news-spur1.maxwell.syr.edu!news.maxwell.syr.edu!news-peer.sprintlink.net!news-sea-19.sprintlink.net!news-in-west.sprintlink.net!news.sprintlink.net!Sprint!204.94.112.34!news.aloha.net!news-w.ans.net!newsfeeds.ans.net!dahlia.singnet.com.sg!newsfeed.singnet.com.sg!id4.nus.edu.sg!nuscc.nus.sg!leonis.nus.sg!sci40034
From: Gan Kwang Yeang Damien <sci40034@leonis.nus.sg>
Newsgroups: bionet.software
Subject: SOS REAMPLIFICATION
Date: Wed, 3 Sep 1997 16:07:35 +0800
Organization: National University of Singapore
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HI! I am a student doing my Honours thesis on RAPD fingerprinting of
guppies. I need desperately need help in a suitable method I can employ to
reamplify RAPD bands excised from silver-stained PAGE gels. IS elution
absolutely necessary and if so what is an efficient method to use??

Can someone please HELP!!!!!


From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed4.bbnplanet.com!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!news-peer.sprintlink.net!news.sprintlink.net!Sprint!EU.net!news0.Belgium.EU.net!Belgium.EU.net!chaos.kulnet.kuleuven.ac.be!usenet
From: Guy Droogmans <guy.droogmans@med.kuleuven.a.c.be>
Newsgroups: bionet.biophysics,bionet.neuroscience,bionet.software
Subject: WinASCD: analysis of single channel and whole cell currents
Date: Thu, 04 Sep 1997 09:46:50 +0200
Organization: kuleuven.ac.be
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Xref: biosci bionet.biophysics:3494 bionet.neuroscience:20217 bionet.software:19430

WinASCD is a program to analyze single channel and whole-cell pClamp
data
(Clampex, Fetchex, AxoTape).
It is a 32-bit (WIn95/NT) updated version of an original DOS program
that I
started writing more than 10 years ago.
It includes the following main features:
1. a data correction module for
        baseline restoration (drift correction)
        background subtraction (correction for leak and capacitative
current)
2. a module for calculating average and peak currents
        ensemble averaged current
        avg current for continuous data
        avg and peak current for triggered data
3. a module to construct linear combinations of records belonging to the

   same or different files
4. a module to fit sum of exponentials or a kinetic model to indivudual
    current traces, ensemble averaged currents and composed records
5. a module for the Analysis of Single Channel Data, including
    Amplitude histogram construction and fit with Gauss peaks
    Kinetic Analysis: idealization, dwell time histograms, first
latencies,
                                burst analysis,  analysis of the number
of events
6. a module for the analysis of current fluctuations, including current
    variance analysis  and FFT.

Each window (graphical or text) can be printed (not a screen dump) or
saved
as a TAB delimited ASCII file for import in e.g. a presentation software

package.
A demo version of the program in which output is disabled is available
from
        ftp://cc5.kuleuven.ac.be/pub/droogmans/winascd.zip
--
Guy Droogmans
Laboratorium voor Fysiologie
Campus Gasthuisberg, KU Leuven
B-3000 Leuven (Belgium)
Tel 32 16 345 726
Fax 32 16 345 991



From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
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From: "Lars Thomsen" <lthomsen@interlynx.net>
Newsgroups: bionet.software
Subject: testing...dont read..having trouble posting..
Date: Wed, 3 Sep 1997 00:09:59 -0400
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 adfasdf




From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
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From: "Lars Thomsen" <lthomsen@interlynx.net>
Newsgroups: bionet.software
Subject: Re: help needed!
Date: Mon, 1 Sep 1997 12:16:08 -0400
Organization: Interlynx
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 What is the algoritm ...I could write a program would do it....if you then
included me somewhere on the article then I would be extremely
happy....wouldnt cost you anything else...

Best Regards
Lars Thomsen




From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
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From: ynakamu@kazusa.or.jp (Yasukazu Nakamura)
Newsgroups: bionet.software
Subject: Btab for blast2
Date: 4 Sep 1997 08:25:45 GMT
Organization: Kazusa DNA Research Institute, Japan.
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Hi,

Have anyone written Btab (like) program for BLAST2 output?

Thanks in advance.

Yaskaz

NAKAMURA Yasukazu      ynakamu@kazusa.or.jp  
Laboratory of Gene Structure 2, Kazusa DNA Research Institute

From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
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From: flora@sage.cc.purdue.edu (Katie Clark)
Newsgroups: bionet.software
Subject: Daylength calculator
Date: Fri, 05 Sep 1997 02:17:31 GMT
Organization: Purdue University
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Recently a student was looking for the photoperiod which occurs in
Crete.  He is trying to grow a plant which is endemic in Crete, in a
growth chamber, and wanted to mimic natural conditions.  The long and
short of it, is that we finally figured out that daylength is the same
around the world if you're at the same latitude.  So, after finding
out what latitude Crete was at, using standard reference sources, we
were ready to find out the daylength.  

I'm writing to tell you of a resource we found which calculates
daylength, given the latitude:
Jarmo's solar Calculator:
http://www.netti.fi/~jjlammi//sun.html

(the program is also available for download, as an excel file!)

If you tell it your time zone, relative to Greenwich standard time, it
will also give you the times for sundown and sunrise, for a given
date.

Katie Clark
Life Sciences Library
Purdue University
West Lafayette IN



From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
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Date: Thu, 04 Sep 1997 08:41:34 -0600
From: uj442ar@sunmailhost.lrz-muenchen.de (Julia Krüger)
Subject: Where can i get a program like BLAST?
Newsgroups: bionet.software
Message-ID: <873377951.5569@dejanews.com>
Organization: Deja News Posting Service
X-Article-Creation-Date: Thu Sep 04 12:59:11 1997 GMT
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I am looking for a program that can act as a database for sequence (DNA+
protein)
information, but that can also compare the data and look for
similarities and identities. Is such a program available?

-------------------==== Posted via Deja News ====-----------------------
      http://www.dejanews.com/     Search, Read, Post to Usenet

From owner-software@net.bio.net Wed Sep 03 23:00:00 1997
Path: biosci!news.Stanford.EDU!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!newsfeed1-hme1!newsfeed.internetmci.com!206.172.150.11!news1.bellglobal.com!sunqbc.risq.qc.ca!newsfeed.microtec.net!news3.sprint-canada.net!wolf.interlynx.net!not-for-mail
From: "Lars Thomsen" <lthomsen@interlynx.net>
Newsgroups: bionet.software
Subject: Cbase...recipe program/chemical database..
Date: Mon, 1 Sep 1997 10:34:23 -0400
Organization: Interlynx
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 Take a look at the screenshots at :

http://home.interlynx.net/~lthomsen/cbase.htm

(you can also download the program as a selfexpanding file containing the
setup)

The program contains a recipe database and a chemical database, which are
coupled together so that you can type e.g. the formula name and the program
will perform a lookup and transfer the remaining info and make the
approatiate calculations regarding your recipe.

We use it in the lab....it works really good...
The printouts are really nice and can be customized by clicking on second
mouse button over the print button.

The program supports unspecified units instead of normal MW. You can also
use the chemical database to hold your stock solutions.

Best Regards
Lars
PS. Im uploading the program right now so if its not availble then wait 20
minutes.




From owner-software@net.bio.net Thu Sep 04 23:00:00 1997
Path: biosci!rutgers!nntp.upenn.edu!newsserver.jvnc.net!ganglia.bms.com!not-for-mail
From: nathan@dna.bms.com (Nathan O. Siemers)
Newsgroups: bionet.software
Subject: Re: Btab for blast2
Date: 04 Sep 1997 21:37:35 -0400
Organization: Bristol-Myers Squibb
Lines: 132
Message-ID: <snkoh68zgkg.fsf@dna.bms.com>
References: <5ulraa$6nv@not1.kazusa.or.jp>
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ynakamu@kazusa.or.jp (Yasukazu Nakamura) writes:
> Hi,
> 
> Have anyone written Btab (like) program for BLAST2 output?
> 
> Thanks in advance.
> 
> Yaskaz
> 

Just another Perl Hacker. Baby Perl, at that.

nathan

| Nathan Siemers - Department of Applied Genomics - Bristol-Myers |
| Squibb Pharmaceutical Research Institute - K23-05, PO Box 4000, |
| Princeton, NJ 08543-4000 - (609) 252-6568 - siemers@bms.com     |


blast22table.pl:

#!/usr/local/bin/perl5
# blast22table.pl
# make tab delimited table of blast2 results
# Nathan Siemers

# just to be nice:

$intorecord = 0;
$count = 0;
$defcount = 0;
$line = 0;

while (<>) {

    # lines we wish were not there...

    if (/^SCORE_MISMATCH/) {
	next;
    }

    @words = split(" ");
    $line++;

    if ($line == 1) {
	$search = $words[0];
    }

    if (/^Query=/){
	$query = $words[1];
    }

    if (/^ +\(.* letters\)/) {
	$words[0] =~ s/\(//;
	$querylength = $words[0];
	$querylength =~ s/\,//g;
    }

    if (/^Database\:/) {
	$db = $words[1];
    }
 

    if (/^ *Length =/) {
	if ($search eq  "TBLASTN" || $search eq "BLASTX" || $search eq "BLASTN") {
	    $lengthline = $intorecord;
	    $scoreline = $lengthline + 4;
	    $idline = $scoreline + 1;
	    $qalignline = $idline + 2;
	    $salignline = $qalignline + 2;
	}
	if ($search eq  "BLASTP") {
	    $lengthline = $intorecord;
	    $scoreline = $lengthline + 2;
	    $idline = $scoreline + 1;
	    $qalignline = $idline + 2;
	    $salignline = $qalignline + 2;
	}
	
	    $hitgenelength[$count] = $words[2];
	    $hitgenelength[$count] =~ s/\,//g;
    }
    
	

    if ( $intorecord == $scoreline) {
	$score[$count] = $words[2];
	$expect[$count] = $words[7];
	$expect[$count] =~ s/\,//;
    }

    if ($intorecord == $idline) {
	$t = $words[2];
	$t =~ s/.*\///g;
	$hitlength[$count] = $t;
	$t = $words[3];
	$t =~ s/[\(\)\%\,]//g;
	$id[$count] = $t;
	$frame[$count] = $words[10];
    }

    if ($intorecord == $qalignline) {
	$qstart[$count] = $words[1];
    }

    if ($intorecord == $salignline) {
	$sstart[$count] = $words[1];
    }

#scan for first line of annotation

    if (/^\>/) {
	$intorecord = 1;
	$count++;
	$accession[$count] = $words[0];
	$accession[$count] =~ s/^>//;
	shift @words;
	$description[$count] = join " ", @words;
    }	
    $intorecord++ if ($intorecord);
}

# print the suckers out
#ignore identical entries! 

for ($i = 1; $i <= $count; $i++) {
    if ($query ne $accession[$i]) {
	print "$query\t$querylength\t$search\t$db\t$accession[$i]\t",
	"$description[$i]\t$hitgenelength[$i]",
	"\t$frame[$i]\t$score[$i]\t$expect[$i]\t$id[$i]\t$hitlength[$i]\t$qstart[$i]\t$sstart[$i]\n";
    }
}

From owner-software@net.bio.net Thu Sep 04 23:00:00 1997
Path: biosci!agate!howland.erols.net!feta.direct.ca!newsfeed.direct.ca!news.he.net!news.pagesat.net!news.itis.com!not-for-mail
From: Petr Kuzmic <pkuzmic@biokin.com>
Newsgroups: bionet.software
Subject: Software available: Biochemical kinetics and equilibria
Date: Fri, 05 Sep 1997 11:24:56 -0500
Organization: BioKin Consulting
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_____________________________________________________
              PUBLIC DOMAIN PROGRAM DYNAFIT AVAILABLE

DynaFit is a program for simulation and least-squares
fitting of biochemical kinetic data.  The user enters
the reaction mechanism symbolically, such as this:

; "Slow, tight" inhibition of HIV proteinase
                                            
[mechanism]                                 
   E + S <==> ES     :     k       ks       
   ES ---> E + P     :     kr               
   E + I <==> EI     :     k1      k2       
   EI <==> EJ        :     k3      k4       

The machine then derives the underlying system of 
differential equations (to compute the time-course of
the reaction) or algebraic equations (to compute the 
composision at equilibrium). 

_____________________________________________________
                                        TEST PROBLEMS

The program should be downloaded along with a set of
test examples, all of them based on real experimental
mostly from biochemical kinetics, but the same methods
can be used for other areas of chemistry and biology.

_____________________________________________________
                                              REVIEWS

A reviewer had this to say about DynaFit: "If you do any 
kind of kinetic data analysis as part of your research 
program, be sure to download DynaFit from the BioKin Web 
site."  (HMS Beagle Newsletter "Software Alert", volume
1997 No. 9).

_____________________________________________________
                                                LINKS

http://www.biokin.com/                    BioKin home
http://www.biokin.com/dynafit/index.shtml ... DynaFit

_____________________________________________________
                                           REFERENCES

P. Kuzmic (1996) Anal. Biochem. 237, 260-273.

_____________________________________________________________
Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
pkuzmic@biokin.com * http://www.biokin.com * 608.256.1269 fax

From owner-software@net.bio.net Thu Sep 04 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!howland.erols.net!vixen.cso.uiuc.edu!news.indiana.edu!not-for-mail
From: gilbertd@bio.indiana.edu (Don Gilbert)
Newsgroups: bionet.software
Subject: loopDloop, RNA secondary structure display editor [java version] update
Date: 5 Sep 1997 00:29:31 GMT
Organization: Biology, Indiana University - Bloomington
Lines: 47
Message-ID: <5unjpb$ntv$1@dismay.ucs.indiana.edu>
NNTP-Posting-Host: chipmunk.bio.indiana.edu



    loopDloop in Java
    an application for visualizing RNA secondary structure 
    version 2.07b, August 1997

loopDloop is a tool for drawing RNA secondary structures in molecular
biology. It reads files of biosequence data with base pairing
information, and displays graphic views of the secondary structure. 
Options allow you to modify, adorn and edit the structure.   Standard
application functions to save, print, edit and manage preferences are
included.   This program will not produce base pairings needed for
secondary structure. 

This software is available at	 
   ftp://iubio.bio.indiana.edu/molbio/loopdloop/java/
   http://iubio.bio.indiana.edu/soft/molbio/loopdloop/java/

LoopDloop is now written as a Java application.   This means that it
will run on most personal computers and workstations as a standard
program or application.  The current release is lacking some features
of prior Macintosh releases.  

Please read the installation instructions included in
loopdloop-doc.html with the software.  The current release takes some
work to install, including perhaps a java runtime system for your
computer.

Java versions of other molecular biology applications built with
the same framework are or will soon be updated :
   SeqPup - a biological sequence editor and analysis program
   Phylodendron - a phylogenetic tree drawing application
   FlyNapp - a FlyBase Drosophila database network application

The Java language has several important aspects and some current
drawbacks for biocomputing software. Please try some of these 
programs and let me know if you think these are going in the
right direction.

Developers will find the source code all these applications in the
iubio:/molbio/java/source folders.  The four current applications
share about 60% code.  This framework may make a useful basis
for other biocomputing applications.



--
-- d.gilbert--biocomputing--indiana u--bloomington--gilbertd@bio.indiana.edu

From owner-software@net.bio.net Thu Sep 04 23:00:00 1997
Path: biosci!agate!newsgate.cuhk.edu.hk!logbridge.uoregon.edu!newsfeed1-hme1!newsfeed.internetmci.com!199.117.161.1!csn!nntp-xfer-1.csn.net!natasha.rmii.com!news1.rmi.net!not-for-mail
From: richard_steinman@cmagroup.com
Newsgroups: bionet.software,co.jobs,misc.jobs.offered,us.jobs.offered
Subject: USA-CO; Boulder/Longmont; Software Engineer; C++, Signal Processing
Date: 5 Sep 1997 20:46:16 GMT
Organization: Career Marketing Associates
Lines: 22
Message-ID: <5upr2o$2v4$1@news.rmi.net>
NNTP-Posting-Host: 206.247.5.4


USA-CO; Boulder/Longmont; Software Engineer; C++, Signal Processing

C, C++ programmer, signal processing, Windows/NT, GUI, convert low level 
Bio signals into data for PC presentaation. Brain waves, EEG, humans and 
animals. Real-time data acquisition. Nerve impulse recording. Would like 
lab experience-data analysis and reduction, familiar with instrumentation. 
New grad to 3 years experience. Small company-software engineers get the 
whole enchillada not just a small piece. Needs to be hungry and eager 
to learn. Really need C++, MFC, WIN32, Windows NT, 95 as well as somewhat 
of a scientific or engineering background. 

Please refer to JO# 2431JMS in your response.



Richard Steinman
Team Leader
rjs@cmagroup.com
IT & Software Solutions Team
Career Marketing Associates
http://www.cmagroup.com/IT.html

From owner-software@net.bio.net Sat Sep 06 23:00:00 1997
From: planning@cyberpromo.com
Subject: Insurance Update
Newsgroups: bionet.software
Organization: Advanced Planning Solutions
NNTP-Posting-Host: 207.99.47.138
Message-ID: <341229b4.0@nntp1.nac.net>
Date: 7 Sep 97 04:12:36 GMT
Lines: 35
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For a free comparison  please go to: 
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From owner-software@net.bio.net Sat Sep 06 23:00:00 1997
Path: biosci!bloom-beacon.mit.edu!eru.mt.luth.se!news-ge.switch.ch!newscore.univie.ac.at!newsfeed.ecrc.net!news-feed1.eu.concert.net!news.worldonline.nl!not-for-mail
From: "The Ghost" <deghost@worldonline.nl>
Newsgroups: bionet.software
Subject: YOU'RE LOOKING FOR NEW SOFTWARE??
Date: 7 Sep 1997 06:43:08 GMT
Organization: World Online
Lines: 8
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NNTP-Posting-Host: ldn1-p31.worldonline.nl
X-Newsreader: Microsoft Internet News 4.70.1155

VISIT MY HOMEPAGE FOR THE NEW CD-ROM LIST	
CRAZY BITES
THE LEGACY
WINFILES
WINZIP
XFILES
AND MUTCH MORE
http://home.worldonline.nl/~deghost

From owner-software@net.bio.net Sat Sep 06 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!howland.erols.net!news.maxwell.syr.edu!eerie.fr!jussieu.fr!rain.fr!wanadoo.fr!not-for-mail
From: Frederic Juge <tarkus@wanadoo.fr>
Newsgroups: bionet.software
Subject: Dissection web site ?
Date: Sun, 07 Sep 1997 11:00:38 +0200
Organization: IPS
Lines: 15
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Hi,

I'm french and my brother is making medecines studies. He asks me for a 
well known web site dedicated to dissection. In fact, the body of a 
prisonner sentenced to death, has been frozen and "cutted into slices".

It is possible now to see all the parts of the body on a web site. Have 
you ever heard about this ? If yes, could you give me the URL ?
Tnaks a lot. Forgiven my bad english.

--------------------------------------------------------
 Frederic JUGE
 Tarkus@Wanadoo.fr
"There's nothing to try, You do it or you don't. Yoda.".
--------------------------------------------------------

From owner-software@net.bio.net Sat Sep 06 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!howland.erols.net!rill.news.pipex.net!pipex!tank.news.pipex.net!pipex!tcp.co.uk!not-for-mail
From: crosley@tcp.co.uk
Newsgroups: bionet.software
Subject: Message for Dennison Moore
Date: Sun, 07 Sep 97 10:38:02 PDT
Organization: Total Connectivity Providers - Internet access for the UK
Lines: 9
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     7/Sep/97
     Dear Dennison Moore,  Thank you for your reply to my cry  
for
     help.  Owing  to a computer problem I have  lost  your  
email
     address. Please send so I can reply. John Shaw.



From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!news-stock.gsl.net!news-dc.gsl.net!news.gsl.net!gip.net!duke.telepac.pt!news.telepac.pt!usenet
From: "Joăo Pedro ( JAZIGO )" <MOP12352@mail.telepac.pt>
Newsgroups: bionet.software
Subject: Wanted: Game Runner 3
Date: 8 Sep 1997 04:01:02 GMT
Lines: 2
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NNTP-Posting-Host: 194.65.227.85
X-Newsreader: Microsoft Internet News 4.70.1155

CAN SOMEONE GET ME THE QUARTERDECK'S "GAME RUNNER 3" ???
answer to MOP12352@mail.telepac.pt

From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!CCVAX.MMC.EDU!willia48
From: willia48@CCVAX.MMC.EDU
Newsgroups: bionet.software
Subject: Workshop Announcement
Date: 8 Sep 1997 10:42:30 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 75
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Message-ID: <Pine.PMDF.3.95.970908124139.538976996D-100000@CCVAX.MMC.EDU>
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Workshop Announcement on Computer Applications in Neuroscience
and Molecular Biology

A workshop organized by Meharry Medical College will be held in
Nashville, TN at Opryland Hotel, November 14-15, 1997 entitled,


"Computers and the biological sciences"


The workshop is intended to serve a broad audience of
individuals, from advanced undergraduates to senior researchers
wishing to incorporate new technologies into their research
programs.  Topics will range from approaches to database
searching of protein sequences, and primary structure-function
analyses to computational neuroscience, including modeling
hippocampal function and studies of neural correlates of visual
awareness. All individuals interested in potential uses of
computer analyses in neuroscience and molecular biology are
welcome.  

Applications for attendance are currently being solicited and
early response is encouraged as the number of individuals who can
participate will be limited in order to keep the workshop
proceedings informal.  In addition, there are a limited number of
scholarships available to cover hotel and registration fees.  
A registration fee of $75 will be charged those not covered by
scholarship.  

Speakers are listed below:

Dr. George Wilcox, University of Minnesota
Dr. Christian Halloy, University of Tennessee
Dr. Neil Burgess, University College, London
Dr. Apostostolos Georgopoulus, Minnesota
Dr. Fabrizio Gabbiani, Cal Tech
Dr. Stephen Altschul, NIH
Dr. Barry Honig, Columbia University
Dr. Temple Smith, Boston University

In order to formally apply or for more information contact the
Minority Biomedical Research Support (MBRS) Program at Meharry
office at the following numbers:

615-327-6847
615-327-6179 (FAX)

or address:

MBRS Program
Meharry Medical College
1005 DB Todd Blvd.
Nashville, TN 37208

Alternatively, you may contact via e-mail either:

Dr. Sanika Chirwa at chirwa83@ccvax.mmc.ed
     or
Dr. Scott Williams at willia48@cccvax.mmc.edu

Note applications should include a CV, a letter indicating your
interest in this symposium and how it would benefit your
career/educational program. 

Minorities are encouraged to apply. 









From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!newsfeed.dacom.co.kr!logbridge.uoregon.edu!newsfeed.ecrc.net!newscore.univie.ac.at!news-ge.switch.ch!news.unige.ch!news
From: grandcha@cmu.unige.ch (Kenneth Grandchamp)
Newsgroups: bionet.software
Subject: Scatchard Analysis and MacLigand and /or PC equivalent...
Date: 8 Sep 1997 16:15:14 GMT
Organization: Centre Medical Universitaire
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Hello !

We would like to know if there is a modern version of
MACLIGAND so as to do a SCATCHARD analysis. 

Does anyone know if there is a PC equivalent that allows
the same analysis ?

Thanks !

Ken.



From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.clark.net!205.252.116.205!howland.erols.net!news-peer.sprintlink.net!news-pull.sprintlink.net!news-in-east.sprintlink.net!news.sprintlink.net!Sprint!199.98.171.3!news.Sage.EDU!hopper!moored
From: Dennison Moore <moored@hopper>
Newsgroups: bionet.software
Subject: Re: Message for Dennison Moore
Date: Mon, 8 Sep 1997 17:28:18 -0400
Organization: The Sage Colleges
Lines: 17
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In-Reply-To: <NEWTNews.873653929.29027.crosley@crosley.tcp.co.uk> 


Dear Mr. Shaw,
this is Dennison Moore and my email address moored@sage.edu     I hope 
the information was useful.

On Sun, 7 Sep 1997 crosley@tcp.co.uk wrote:

> 
>      7/Sep/97
>      Dear Dennison Moore,  Thank you for your reply to my cry  
> for
>      help.  Owing  to a computer problem I have  lost  your  
> email
>      address. Please send so I can reply. John Shaw.
> 
> 
> 
> 

From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!agate!ihnp4.ucsd.edu!munnari.OZ.AU!news.ecn.uoknor.edu!feed1.news.erols.com!news.voicenet.com!dsinc!nntp.upenn.edu!taurus.fccc.edu!sauder
From: sauder@polaris.fccc.edu (John Michael Sauder)
Newsgroups: bionet.software
Subject: Re: Dissection web site ?
Date: 8 Sep 1997 21:15:49 GMT
Organization: Fox Chase Cancer Center, Philadelphia, PA
Lines: 9
Message-ID: <5v1pu5$jil$1@taurus.fccc.edu>
References: <34126D36.669@wanadoo.fr>
NNTP-Posting-Host: polaris.fccc.edu

In article <34126D36.669@wanadoo.fr> Frederic Juge <tarkus@wanadoo.fr> writes:
>Hi,
>
>I'm french and my brother is making medecines studies. He asks me for a 
>well known web site dedicated to dissection. In fact, the body of a 
>prisonner sentenced to death, has been frozen and "cutted into slices".
> Tarkus@Wanadoo.fr

	http://www.nlm.nih.gov/research/visible/visible_human.html

From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
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From: "Joseph A. Near" <nearj@indiana.edu>
Newsgroups: bionet.software
Subject: Re: Scatchard Analysis and MacLigand and /or PC equivalent...
Date: Mon, 08 Sep 1997 13:52:56 -0500
Organization: Indiana University
Lines: 22
Message-ID: <34144988.10F7@indiana.edu>
References: <5v18ai$ltu@uni2f.unige.ch>
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Is this the program adapted by G.A.McPherson from LIGAND?  If so, there
is a PC equivalent.  Kind of quirky but it works OK.  Latest version I
have is about 7 years old, runs in W95, published by BIOSOFT, 68 Hills
Rd., Cambridge CB2 1LA, UK.  I get junk mail from them every once in a
while, but always throw it away so can't give you a current address.

Joe Near


Kenneth Grandchamp wrote:
> 
> Hello !
> 
> We would like to know if there is a modern version of
> MACLIGAND so as to do a SCATCHARD analysis.
> 
> Does anyone know if there is a PC equivalent that allows
> the same analysis ?
> 
> Thanks !
> 
> Ken.

From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.clark.net!199.60.229.5!feta.direct.ca!newsfeed.direct.ca!news1.chicago.cic.net!iagnet.net!newsspool.doit.wisc.edu!news.itis.com!not-for-mail
From: Petr Kuzmic <pkuzmic@biokin.com>
Newsgroups: bionet.software
Subject: Re: Scatchard Analysis and MacLigand and /or PC equivalent...
Date: Mon, 08 Sep 1997 12:35:20 -0500
Organization: BioKin Consulting
Lines: 49
Message-ID: <34143758.A5BF2016@biokin.com>
References: <5v18ai$ltu@uni2f.unige.ch>
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Kenneth Grandchamp wrote:

> We would like to know if there is a modern version of
> MACLIGAND so as to do a SCATCHARD analysis.
> 
> Does anyone know if there is a PC equivalent that allows
> the same analysis ?

Equilibrium binding data following any arbitrary mechanism
(stoichiometry) can be analyzed by using the program DYNAFIT [P. Kuzmic
(1996) Anal. Biochem. 237, 260-273].  The program is available as a
freeware from BioKin Consulting.  

An example problem distributed with DYNAFIT describes the binding of a
trimeric protein P (the enzyme nuclease) to DNA at two different sites. 
The analysis is performed by using a 'script' file, where the binding
mechanism is described as follows:

[mechanism]
   P + P + P <=> T    :   K(tri)  equil
   T + D <==> TD      :   K(1)    equil
   TD + T <==> T2D    :   K(2)    equil

The machine then automatically constructs the mathematical model for the
bindind data and gives back the best-fit values of the equilibrium
constants (here, K(tri), K(1), and K(2).  Another relevant example
describes two-site cooperative binding in the presence of non-specific
interactions:

[mechanism]
   L + R  <==> LR   :  K1  equil     
   L + LR <==> L2R  :  K2  equil     
   L + N  <==> LN   :  Kn  equil ; nonspecific!    

The program runs on the PC, Macintosh, and several Unix platforms.

LINKS:

http://www.biokin.com/
http://www.biokin.com/dynafit/index.shtml
http://www.biokin.com/dynafit/tutorial/nuclease.shtml
http://www.biokin.com/dynafit/tutorial/nonspec.shtml

------------------------+------------------------
Petr Kuzmic, Ph.D.      |          (608) 256-4790
BioKin Consulting       |      fax (708) 256-1269
P.O. Box 8336           |      pkuzmic@biokin.com
Madison WI 53708        |   http://www.biokin.com
------------------------+------------------------

From owner-software@net.bio.net Sun Sep 07 23:00:00 1997
Path: biosci!agate!hammer.uoregon.edu!vixen.cso.uiuc.edu!newsfeed1-hme1!newsfeed.internetmci.com!128.230.129.106!news.maxwell.syr.edu!pumpkin.pangea.ca!news.mira.net.au!news.netspace.net.au!news.mel.connect.com.au!news.per.connect.com.au!news.wantree.com.au!NewsWatcher!user
From: csf@curtinfurn.com.au (Heath)
Newsgroups: bionet.software
Subject: Now Up-to-Date & Contact
Date: Mon, 08 Sep 1997 16:41:49 +0800
Organization: Curtin System Furniture
Lines: 4
Message-ID: <csf-0809971641500001@192.163.1.130>
NNTP-Posting-Host: 203.33.199.158

We are looking to talk to someone who has used Now Up-to-Date & Contact
Organiser program.
Please email Heath at:
csf@curtinfurn.com.au

From owner-software@net.bio.net Mon Sep 08 23:00:00 1997
Newsgroups: bionet.software
Path: biosci!daresbury!server5.netnews.ja.net!nntp.news.xara.net!xara.net!newsfeed.nacamar.de!feta.direct.ca!newsfeed.direct.ca!newsfeed1-hme1!newsfeed.internetmci.com!131.187.1.131!malgudi.oar.net!picker!news
From: Sue Simon <simon@xray.picker.com>
Subject: OH/CLEV  Product Line Manager
Content-Type: text/plain; charset=us-ascii
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Date: Tue, 9 Sep 1997 18:40:21 GMT
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Lines: 26

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From owner-software@net.bio.net Mon Sep 08 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!news-spur1.maxwell.syr.edu!news.maxwell.syr.edu!newsfeed.nacamar.de!newscore.univie.ac.at!03-newsfeed.univie.ac.at!news.uibk.ac.at!not-for-mail
From: Stefan Andreatta <stefan.andreatta@uibk.ac.at>
Newsgroups: bionet.software
Subject: simulation program for finding prey in 3D-space ???
Date: Tue, 09 Sep 1997 10:15:24 +0200
Organization: University of Innsbruck
Lines: 12
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We are working on the problem of how flagellates are able to find their
bacterial prey in the open water. So we would need a program that lets
us model the encounter between particles of different size in a
3d-space. Has anyone come across such a program, programmed some costume
solution that would be available or knows some environment that would be
particular apt to solve this problem?

Thanks for any suggestions
____________________________________
Stefan Andreatta
University of Innsbruck, Austria
Department of Zoology and Limnology

From owner-software@net.bio.net Mon Sep 08 23:00:00 1997
Path: biosci!daresbury!uninett.no!sn.no!Norway.EU.net!EU.net!news-peer.sprintlink.net!news-sea-19.sprintlink.net!news-in-west.sprintlink.net!news.sprintlink.net!Sprint!199.0.65.142!news-feed1.tiac.net!cam-news-hub1.bbnplanet.com!cam-news-feed1.bbnplanet.com!news.bbnplanet.com!cocoa.brown.edu!news
From: Pascal_Bochet@brown.edu (Pascal_Bochet)
Newsgroups: bionet.software
Subject: Laptop remote
Date: 9 Sep 1997 14:19:15 GMT
Organization: Brown University, Providence, RI -- USA
Lines: 10
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Hello
This is probably not the most appropriate news group but I have the strong 
feeling that bionet is my corner of the wood. 
Does anyone know if it is possible to turn a normal computer into a remote 
controle for TV and VCR using the infra red port? Are there any program to do 
that ?
Thank you for any help. 
Pascal_Bochet@brown.edu 
 


From owner-software@net.bio.net Mon Sep 08 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.clark.net!4.1.16.34!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!baron.netcom.net.uk!netcom.net.uk!server3.netnews.ja.net!news.ox.ac.uk!worf.molbiol.ox.ac.uk!rgrant
From: rgrant@see.sig.for.address (Richard P Grant)
Newsgroups: bionet.general,bionet.software
Subject: Blue/Greybox Fonts
Date: 9 Sep 1997 08:45:28 GMT
Organization: Oxford University
Lines: 16
Message-ID: <5v32b8$ps9$1@news.ox.ac.uk>
NNTP-Posting-Host: worf.molbiol.ox.ac.uk
Keywords: Fonts for aa display
X-Newsreader: TIN [version 1.2 PL2]
Xref: biosci bionet.general:28062 bionet.software:19456

A while ago someone announced 3 Mac font suitcases, called Bluebox,
Greybox and Blueline for displaying similar amino acids.

Now, for some reason, the set I've got on an LC won't display on a PPC,
and I'd like to get hold of the originals.  Stupidly, I've lost the
original post/refernce/URL.  Please point me in the right direction.

Thanks,

Richard


--
Richard P. Grant  MA  DPhil          University of Oxford | rgrant@molbiol
http://www.molbiol.ox.ac.uk/~rgrant  FFPGP                |    ox ac uk
------# 'At this time we are currently boarding...' - heard at JFK #------

From owner-software@net.bio.net Mon Sep 08 23:00:00 1997
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From: info@pagrs.com
Newsgroups: bionet.software
Subject: FREE MOTOROLA PAGERS & SEIKO WATCHES!
Date: 9 Sep 97 04:06:02 GMT
Organization: DS
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NNTP-Posting-Host: 165.113.201.24

********************************************************

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From owner-software@net.bio.net Mon Sep 08 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.clark.net!4.1.16.34!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!mindspring!news.mindspring.com!usenet
From: expomed@mindspring.com (&&&&)
Newsgroups: bionet.software
Subject: Not Another Visible Human Project Web Site
Date: 9 Sep 1997 00:50:41 GMT
Organization: Expomed Inc.
Lines: 38
Message-ID: <5v26h1$qn0@camel15.mindspring.com>
NNTP-Posting-Host: ip3.akron.oh.pub-ip.psi.net
Mime-Version: 1.0
X-Newsreader: WinVN 0.93.14

We would like to announce a new web site based on the
National Library of Medicine's Visible Human Project.

The site is VisualMan.Com- http://www.visualman.com/index.htm.

There is a demo of the Data Express Visual Man CD in which
you can click on a portion of the body and see the corresponding
image. The demo will enable you to view images from head to foot. 
Over time we will be adding a "Gallery" section for some of the 
other software titles based on the NLM VHP. Images will be added 
for titles from Gold Standard Multimedia and Research Systems Inc.

AND NOW FOR THE SITE OF THE MONTH.
The site of the month is a search engine I find very
useful. It is called Inference Find and is located at
the following URL- http://www.inference.com/ifind/. 
As it says on the site- "Inference Find is the first and
only search toll that calls out in parallel all the
best search engines on the internet, merges the results,
removes redundancies, and clusters the results into
neat understandable groupings". The site queries WebCrawler,
Yahoo, Lycos, Altavista, Infoseek, and Excite. I did a 
search for the term "medical ethics" and the search 
returned some great sites, very nicely catagorized.
Expomed is not connected in any way with this site.

Thanks

-- 
*>*>*>*>*>*>*>*>*>*>*>*>*>    <*<*<*<*<*<*<*<*<*<*<*<*<*<*
Martin Thomas, expomed@mindspring.com
http://www.expomed.com/  http://www.visualman.com/
Join our discussion on medical ethics with The Doctor's
Dilemma, Essentials of Medical Ethics CD-ROM at:
http://www.expomed.com/ethics.htm
For a free DOS catalog send email with a mailing address.
<><><><><><><>E<>X<>P<>O<>M<>E<>D<><>I<>N<>C<><><><><><><><>


From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed4.bbnplanet.com!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!howland.erols.net!netnews.com!news2.euro.net!news.euro.net!usenet
From: mbleeker@euronet.nl (Marco Bleeker)
Newsgroups: bionet.software
Subject: Desirable Attributes of Ecological Software
Date: 10 Sep 1997 00:17:16 GMT
Organization: EuroNet Internet
Lines: 14
Message-ID: <3415e644.9662233@news.euro.net>
NNTP-Posting-Host: p615.asd.euronet.nl
X-Newsreader: Forte Free Agent 1.1/32.230


"Desirable Attributes of Ecological Software"
is the title of a "paper" I have put on-line at the following URL: 

http://www.euronet.nl/users/mbleeker/prog/ecoatt-e.html

This checklist of desirable attributes might be of use to programmers and
reviewers of eco-software, as well as future users. The document has been
discussed in our small workgroup in Holland, further contributions are welcome.

Thanks, Marco
-- 
<mbleeker@euronet.nl>------------------<Marco Bleeker, Amsterdam, NL>
<CHEZ MARCO'S BOTANY PAGES>---<http://www.euronet.nl/users/mbleeker/>
<Plants Programs Pictures>------------------------------<nl-en-de-fr>

From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!bloom-beacon.mit.edu!eru.mt.luth.se!news-ge.switch.ch!news-kar1.dfn.de!newsfeed.nacamar.de!oleane!jussieu.fr!moka.ccr.jussieu.fr!not-for-mail
From: ptitjean@ccr.jussieu.fr (Michel PETITJEAN)
Newsgroups: bionet.software,bionet.molec-model
Subject: protein / predicting 3D-structure perturbation
Date: 10 Sep 1997 15:49:29 +0200
Organization: CCR - Universites Paris VI/VII - Paris - France
Lines: 9
Message-ID: <5v68h9$1scm@moka.ccr.jussieu.fr>
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Xref: biosci bionet.software:19464 bionet.molec-model:1785

I have the x,y,z coordinates of a protein in PDB format.
One of the residues has an H-bonding with the rest of the protein.
Now I replace this residue with an other one which offers no H-bonding.
How can I predict the perturbations induced on the 3D-structure ?
Is there softwares for that (free or not) ?
Thanks.

Michel Petitjean,                     Email: petitjean@itodys.jussieu.fr
ITODYS (CNRS, URA34)                         ptitjean@ccr.jussieu.fr

From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!agate!howland.erols.net!news-peer.sprintlink.net!news-sea-19.sprintlink.net!news-in-west.sprintlink.net!news.sprintlink.net!Sprint!169.197.1.4!news.azstarnet.com!dialup04ip01.tus.azstarnet.com!user
From: jacobs@azstarnet.com (John S Jacobs Anderson)
Newsgroups: bionet.software
Subject: Re: Good C compiler for Mac?
Date: Wed, 10 Sep 1997 07:28:30 -0700
Organization: Starnet
Lines: 20
Distribution: world
Message-ID: <jacobs-1009970728300001@dialup04ip01.tus.azstarnet.com>
References: <34165531.566D@interlog.com>
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X-Newsreader: MT-NewsWatcher 2.3.1


In article <34165531.566D@interlog.com>, oxidizer@INTERLOG.COM wrote:

>As part of a fourth-year undergraduate reserach project, I need to
>program a population genetic simulation.  I'm looking for a good C
>compiler for a PowerMac; any suggestions?


One word: CodeWarrior.  More options than you can shake a stick at, and
probably more than you need. You should be able to get a good price
(academically).

As far as I know (and I looked _hard_ about 9-12 months ago) there aren't
any _good_ (ie useable) free C compliers for the Mac.

Good Luck
John
--------------------------------------------------------------------
John S. J. Anderson                 http://www.azstarnet.com/~jacobs
Grad Student, MCB Depšt, U. of Az.       mailto:jacobs@azstarnet.com
"You want some? ... HUH?" - [Army of Darkness].

From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!howland.erols.net!feed1.news.erols.com!winter.news.erols.com!news
From: Chris Baba <cbaba@erols.com>
Newsgroups: bionet.software
Subject: Great Shareware for the lab!
Date: Tue, 09 Sep 1997 22:42:29 -0400
Organization: Erol's Internet Services
Lines: 13
Message-ID: <34160914.58D8@erols.com>
Reply-To: cbaba@erols.com
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X-Mailer: Mozilla 3.0Gold (Win95; I)


If you work in a lab as I do, you should try out the Chemical Calculator
program which I wrote.
    Chemical Calculator (tm) is a shareware program designed for
chemists, biologists and other scientific professionals. Its main
purpose is to perform the calculations involved in the calculation of
the amount of reagent to use when mixing up solutions.  Chemical
Calculator is a shareware program.  You can use a fully functional
version for 90 days and if you like it you can register it for $30.00. 
If you don't register Chemical Calculator you can still use a slightly
disabled version for free after the 90 day trial period.  Requires
Windows 3.1 or later.  More information is available on the Chemical
Calculator Web Site: "http://www.erols.com/cbaba".  The program can also
be downloaded from there.

From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed4.bbnplanet.com!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!howland.erols.net!vixen.cso.uiuc.edu!news.indiana.edu!not-for-mail
From: gilbertd@bio.indiana.edu (Don Gilbert)
Newsgroups: bionet.software
Subject: Re: Good C compiler for Mac?
Date: 10 Sep 1997 19:16:48 GMT
Organization: Biology, Indiana University - Bloomington
Lines: 17
Message-ID: <5v6rn0$opu$1@dismay.ucs.indiana.edu>
References: <34165531.566D@interlog.com>
NNTP-Posting-Host: chipmunk.bio.indiana.edu


Check w/ your campus bookstore or other edu software vendor.
Metrowerks Codewarrior is the best, and a full professional
programming package, including C, C++, Pascal, Java and probably
other compilers; including MacOS and MSWin dev environs (at
least my copy had both); with an academic price still around $120
(used to be $99).

Metrowerks does make a special student edition; I haven't seen
it or its price, except is it under $100 in cost.

See http://www.metrowerks.com/  if your campus stores haven't
got it.

-- Don

--
-- d.gilbert--biocomputing--indiana u--bloomington--gilbertd@bio.indiana.edu

From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!CORIN.NLM.NIH.GOV!madden
From: madden@CORIN.NLM.NIH.GOV (Tom Madden)
Newsgroups: bionet.software
Subject: New NCBI toolkit and BLAST 2.0 release
Date: 10 Sep 1997 10:39:39 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 108
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <199709101739.NAA03419@corin.nlm.nih.gov>
NNTP-Posting-Host: net.bio.net


A new release of the NCBI toolkit as well as BLAST 2.0.2 binaries
are now available from the NCBI FTP Site (ncbi.nlm.nih.gov).  The
toolkit archive contains source code to compile BLAST 2.0.2 as well as
a small number of incremental changes in the ASN.1 specification.
Toolkit archives may be found under 'toolbox/ncbi_tools'.  BLAST binaries 
may be found under 'blast/executables'.



BLAST 2.0 - BLAST 2.0 can produce gapped alignments and is capable of 
position-specific-iterated BLASTp (PSI-BLAST).  Compared to the 1.4 release of
BLAST, there are also signficant performance enhancements as well as extensive 
changes to the text report and the format of the databases.  BLAST 2.0
uses threads for multi-processing, using the NCBI threads library.
Three BLAST programs may be compiled in the demo of the toolbox or obtained
from the 'blast/executables' directory.   They are:

formatdb: formats FASTA files as BLAST databases for BLAST 2.0.

blastall: perform all five flavors of blast comparison.  blastn and blastp offer 
fully 
	gapped alignments.  blastx and tblastn have 'in-frame' gapped alignments 
and 
	use sum statistics to link alignments from different frames. tblastx 
provides 
	only ungapped alignments.

blastpgp: performs gapped blastp searches and can be used to perform iterative 
	searches in psi-blast mode.

Additional information may be obtained from the README in the BLAST directory of 
the
FTP site and from the NCBI BLAST pages.




ASN.1 Spec Changes for 1997

biblio.asn
  Cit-pat - some fields made optional to allow patent applications to be legal
            Cit-pat.number OPTIONAL
            Cit-pat.date-issue OPTIONAL
    -- Patent number and date-issue were made optional in 1997 to
    --   support patent applications being issued from the USPTO
    --   Semantically a Cit-pat must have either a patent number or
    --   an application number (or both) to be valid

medline.asn
  added ML-field to support other MEDLINE line types
  added Medline-entry.status
  added gdb as a valid Medline-si type

Medline-entry ::= SEQUENCE {
    uid INTEGER OPTIONAL ,      -- MEDLINE UID, sometimes not yet available if 
from PubMed
    em Date ,                   -- Entry Month
    cit Cit-art ,               -- article citation
    abstract VisibleString OPTIONAL ,
    mesh SET OF Medline-mesh OPTIONAL ,
    substance SET OF Medline-rn OPTIONAL ,
    xref SET OF Medline-si OPTIONAL ,
    idnum SET OF VisibleString OPTIONAL ,  -- ID Number (grants, contracts)
    gene SET OF VisibleString OPTIONAL ,
    pmid PubMedId OPTIONAL ,               -- MEDLINE records may include the 
PubMedId
    pub-type SET OF VisibleString OPTIONAL, -- may show publication types 
(review, etc)
    mlfield SET OF Medline-field OPTIONAL ,  -- additional Medline field types
    status INTEGER {
        publisher (1) ,      -- record as supplied by publisher
        premedline (2) ,     -- premedline record
        medline (3) } DEFAULT medline }  -- regular medline record


Medline-field ::= SEQUENCE {
    type INTEGER {              -- Keyed type
        other (0) ,             -- look in line code
        comment (1) ,           -- comment line
        erratum (2) } ,         -- retracted, corrected, etc
    str VisibleString ,         -- the text
    ids SEQUENCE OF DocRef OPTIONAL }  -- pointers relevant to this text

DocRef ::= SEQUENCE {           -- reference to a document
    type INTEGER {
        medline (1) ,
        pubmed (2) ,
        ncbigi (3) } ,
    uid INTEGER }


seq.asn
  MolInfo.tech - added names for HTG classes already implemented
  Annotdesc.region - added seqloc. If present, all annots in this SeqAnnot
                      are within this region. Optimization on big seqs.

seqfeat.asn
  added OrgMod.specimen-voucher - new organism qualifier
  added OrgMod.old-name - used internally at NCBI
  added BioSource.is-focus - for distinguishing biological focus of
      multiple source features.
  added Seq-feat.pseudo so any feature can be flagged explicitly as
      belonging to a pseudogene
  added Seq-feat.except-text for an explanation of the exception when
      Seq-feat.except is TRUE. Currently this text is in Seq-feat.comment
      in backbone records and GBQuals in some other genbank records.


From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed4.bbnplanet.com!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!newsfeed.internetmci.com!newsfeed.internetmci.com!192.220.251.22!netnews.nwnet.net!news-hub.interserv.net!news.sprynet.com!not-for-mail
From: Ambal MD <ambal@sprynet.com>
Newsgroups: bionet.software
Subject: Neural network software
Date: Wed, 10 Sep 1997 17:19:44 -0500
Organization: UAB
Lines: 10
Message-ID: <34171CFF.5E11BD92@sprynet.com>
Reply-To: ambal@sprynet.com
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Hi Everyone!
Does anyone know a good source of neural network software that can be
easily adapted for biological data and forecasting?
--
Ambal MD
UAB
Birmingham, AL
http://home.sprynet.com/sprynet/ambal



From owner-software@net.bio.net Tue Sep 09 23:00:00 1997
Path: biosci!INTERLOG.COM!oxidizer
From: oxidizer@INTERLOG.COM
Newsgroups: bionet.software
Subject: Good C compiler for Mac?
Date: 10 Sep 1997 00:05:49 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 3
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NNTP-Posting-Host: net.bio.net

As part of a fourth-year undergraduate reserach project, I need to
program a population genetic simulation.  I'm looking for a good C
compiler for a PowerMac; any suggestions?

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!U.WASHINGTON.EDU!egn
From: egn@U.WASHINGTON.EDU ("E. Kolker")
Newsgroups: bionet.software
Subject: (none)
Date: 10 Sep 1997 20:28:43 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 202
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <199709110328.UAA31109@saul7.u.washington.edu>
NNTP-Posting-Host: net.bio.net


          	         CALL FOR PAPERS

               SECOND ANNUAL INTERNATIONAL CONFERENCE ON
                
                    COMPUTATIONAL MOLECULAR BIOLOGY

                           (RECOMB 98)


                      March 22 - 25, 1998  
                         New York City                   
                                                                  

                           Sponsored by 

                 Association for Computing Machinery 

                              SIGACT

                         with support from

                         SLOAN Foundation 
                      US Department of Energy
 
          http://www.mssm.edu/biomath/recomb98.html


The Second Annual Conference on Research in Computational Molecular
Biology (RECOMB 98), sponsored by the Association for Computing Machinery
Special Interest Group on Algorithms and Computation Theory (ACM-SIGACT) 
with support from the SLOAN Foundation, and US Department of Energy will
be held in New York City, March 22 - 25, 1998. Papers reporting on 
original research (both theoretical and experimental) in all areas of
computational molecular biology are sought, including surveys of important
recent results/directions. Typical but not exclusive topics of interest
include: 

- Genomics
- Molecular sequence analysis
- Recognition of  genes and regulatory elements
- Molecular evolution
- Protein structure
- Combinatorial libraries and drug design


ABSTRACT SUBMISSION: 
Authors are requested to send 10 copies (preferably two sided copies) of a
detailed extended abstract (5-10 pages)  to: 

                        Professor Pavel Pevzner
                        RECOMB 98 Program Chair
                        University of Southern California
                        Department of Mathematics, DRB 155
                        Los Angeles, CA 90089-1113

An abstract must be received by October 20, 1997. This is a firm deadline. 
Simultaneous submission to another conference or journal is allowed. 


CONFERENCE PROCEEDINGS: 
The extended abstracts for the Conference will be published by ACM Press
and will be available at the Conference. A selection of the accepted
extended abstracts in their final journal versions will be invited to
appear in a special issue of the Journal of Computational Biology devoted
to RECOMB 98.


NOTIFICATION: 
The conference submissions will be refereed by the program committee. 
Authors will be notified of acceptance or rejection by a letter mailed on
or before December 15, 1997. A final copy of each accepted paper is
required by January 10, 1997. An author of each accepted paper is expected
to attend the Symposium and present the paper; otherwise alternative
arrangements should be made to have the paper presented. 


ABSTRACT PREPARATION:
An abstract should start with a succinct statement of the problem, the
results achieved, their significance and a comparison with previous work.
This material should be understandable to nonspecialists. A technical
exposition directed to the specialist should follow. The length, excluding
cover page and bibliography, should not exceed 10 pages. The manuscript
should be easy to read, preferably using 11 point font size on U.S.
standard 8 1/2 by 11 inch paper.  If authors believe that more details are
necessary to substantiate the claims of the paper, they may include a
clearly marked appendix. An E-mail address for the contact author should
be included.


INVITED SPEAKERS:

Charles Cantor (Boston University)
Thomas Caskey (Merck)
David Cox (Stanford University)
Ron Davis (Stanford University)
Klaus Gubernator (CombiChem)
Joshua Lederberg (Rockfeller University)
Michael Levitt (Stanford University)
David Schwartz (New York University)
John Yates (University of Washington)


CONFERENCE EVENTS

RECOMB 98 will feature 9 invited lectures including the following conference 
events: 

THE STANISLAW ULAM MEMORIAL COMPUTATIONAL BIOLOGY ADDRESS 
awarded by RECOMB to a scientist who has made major contributions 
in the computational aspects of the field. Professor Joshua Lederberg 
of Rockfeller University will deliver the Statislav Ulam Memorial 
Computational Biology Address.

THE DISTINGUISHED BIOLOGY LECTURE 
awarded by RECOMB to a scientist who has made major contributions 
in the biological aspects of the field. Professor Ron Davis 
of Stanford University will deliver the Distinguished Biology Lecture.

THE DISTINGUISHED NEW TECHNOLOGIES LECTURE 
describing emerging, new technologies. Professor David Cox
of Stanford University will deliver the Distinguished New Technologies Lecture.


BEST PAPER BY A YOUNG SCIENTIST AWARD.
This award will be given to the best paper written solely by one or more
recent graduates or students. An abstract is eligible if all authors are
recent graduates (within 2 years from Ph.D.) or full-time students at the
time of submission. This should be indicated in the submission letter. The
program committee may decline to make the award or may split it among
several papers. 


STEERING COMMITTEE: 

Sorin Istrail, RECOMB General Vice-Chair (Sandia National Laboratories)
Richard Karp (University of Washington)
Thomas Lengauer (GMD-SCAI, Germany)
Pavel Pevzner, RECOMB General Chair (University of Southern California) 
Ron Shamir (Tel-Aviv University, Israel)
Michael Waterman, RECOMB General Chair (University of Southern California)


PROGRAM COMMITTEE:

Craig Benham (Mount Sinai School of Medicine)
Gary Benson (Mount Sinai School of Medicine) 
Bonnie Berger (MIT)
Martin Farach (Rutgers University)
Phil Green (University of Washington)
Dan Gusfield  (University of California Davis)
David Haussler (University of California Santa Cruz)
Sorin Istrail (Sandia National Laboratories)
Richard Karp (University of Washington)
Minoru Kanehisa (Kyoto University, Japan)
Eugene Koonin (National Center for Biotechnology Information) 		 
Thomas Lengauer (GMD-SCAI, Germany)
Webb Miller (Pennsylvania State University) 
Gene Myers  (University of Arizona) 
Pavel Pevzner, Program Committee Chair (University of Southern California)
David Searls (SmithKline Beecham)
Ron Shamir (Tel-Aviv University, Israel) 
Terry Speed (University of California Berkeley)
Martin Vingron (German Cancer Center)
Michael Waterman (University of Southern California)


ORGANIZING COMMITTEE:

Craig Benham (Mount Sinai School of Medicine)
Gary Benson, Conference Chair (Mount Sinai School of Medicine)  
Martin Farach (Rutgers University)
Eugene Kolker, Publicity Chair (University of Washington)



Information about local arrangements can be obtained by consulting the
conference web page
    
	http://www.mssm.edu/biomath/recomb98.html
 
or from the Conference Chair:

	     Professor Gary Benson
	Department of Biomathematical Sciences
	          Box 1023
	  The Mount Sinai Medical Center
	  One Gustave L. Levy Place
	   New York, NY 10029-6574
	        (212) 241-5777 phone
                (212) 860-4630 fax
         benson@ecology.biomath.mssm.edu


	   
--------------------------------------------------------------------
Eugene Kolker                                           
Dept of Molecular Biotechnology, Box 357730     Tel: +1-206-685-6941
University of Washington School of Medicine     Fax: +1-206-685-7301
Seattle, WA 98195-7730, USA                     egn@u.washington.edu
     NEW (!)  WEB: http://bozeman.genome.washington.edu/~eugene


From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!rutgers!nntp.upenn.edu!news.misty.com!www.nntp.primenet.com!globalcenter1!news.primenet.com!nntp.primenet.com!howland.erols.net!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!newsfeeds.sol.net!news.pagesat.net!news.itis.com!not-for-mail
From: Petr Kuzmic <pkuzmic@biokin.com>
Newsgroups: bionet.software
Subject: Re: Good C compiler for Mac?
Date: Thu, 11 Sep 1997 08:06:17 -0500
Organization: BioKin Consulting
Lines: 19
Message-ID: <3417ECC9.74518DE8@biokin.com>
References: <34165531.566D@interlog.com>
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oxidizer@INTERLOG.COM wrote:

> I'm looking for a good C
> compiler for a PowerMac; any suggestions?

Metrowerks is very easy to use, and it's cheap.  Apple MPW/C seems to me
more easily interfaced with Fortran tools from various vendors.   If you
were to integrate a lot of existing Fortran code into you application,
that would be the only reason I'd at least take a look at MPW.

I don't know about the legality of the following suggestion, but...
there must be a lot of people (like me) with several old versions of
Apple MPW and MetroWerks Code Warrior sitting around.  How about getting
hold (by a license transfer or whatever) of an obsolete copy?  It should
do fine for your student project.

_____________________________________________________________
Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
pkuzmic@biokin.com * http://www.biokin.com * 608.256.1269 fax

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!agate!usenet.INS.CWRU.Edu!news.apk.net!uunet!in4.uu.net!204.253.208.40!insync!news.maxwell.syr.edu!newsfeed.direct.ca!newshub1.home.com!news.home.com!news1.best.com!nntp1.ba.best.com!not-for-mail
From: Scott Le Grand <legrand@teslaNOSPAM.mbi.uclaFNORD.edu>
Newsgroups: bionet.software,bionet.molec-model
Subject: Re: protein / predicting 3D-structure perturbation
Date: Wed, 10 Sep 1997 21:27:54 -0700
Lines: 19
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Xref: biosci bionet.software:19472 bionet.molec-model:1786

Michel PETITJEAN wrote:
> 
> I have the x,y,z coordinates of a protein in PDB format.
> One of the residues has an H-bonding with the rest of the protein.
> Now I replace this residue with an other one which offers no H-bonding.
> How can I predict the perturbations induced on the 3D-structure ?
> Is there softwares for that (free or not) ?
> Thanks.

There are numerous prediction packages available.  None of them
have been shown to be of any predictive value whatsoever anywhere
but within the scientific papers that describe them.  However,
I'm sure the developers of said packages would insist on
disagreeing with this statement

Your best bet at prediction would be to assume the structure
did not change as a result of the mutation.

Scott Le Grand

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!GENOME.BIOTECH.WASHINGTON.EDU!eugene
From: eugene@GENOME.BIOTECH.WASHINGTON.EDU (Eugene Kolker)
Newsgroups: bionet.software
Subject: RECOMB98 Invited Speakers
Date: 11 Sep 1997 14:26:00 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
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          	         CALL FOR PAPERS

               SECOND ANNUAL INTERNATIONAL CONFERENCE ON
                
                    COMPUTATIONAL MOLECULAR BIOLOGY

                           (RECOMB 98)


                      March 22 - 25, 1998  
                         New York City                   
                                                                  

                           Sponsored by 

                 Association for Computing Machinery 

                              SIGACT

                         with support from

                         SLOAN Foundation 
                      US Department of Energy
 
          http://www.mssm.edu/biomath/recomb98.html


The Second Annual Conference on Research in Computational Molecular
Biology (RECOMB 98), sponsored by the Association for Computing Machinery
Special Interest Group on Algorithms and Computation Theory (ACM-SIGACT) 
with support from the SLOAN Foundation, and US Department of Energy will
be held in New York City, March 22 - 25, 1998. Papers reporting on 
original research (both theoretical and experimental) in all areas of
computational molecular biology are sought, including surveys of important
recent results/directions. Typical but not exclusive topics of interest
include: 

- Genomics
- Molecular sequence analysis
- Recognition of  genes and regulatory elements
- Molecular evolution
- Protein structure
- Combinatorial libraries and drug design


ABSTRACT SUBMISSION: 
Authors are requested to send 10 copies (preferably two sided copies) of a
detailed extended abstract (5-10 pages)  to: 

                        Professor Pavel Pevzner
                        RECOMB 98 Program Chair
                        University of Southern California
                        Department of Mathematics, DRB 155
                        Los Angeles, CA 90089-1113

An abstract must be received by October 20, 1997. This is a firm deadline. 
Simultaneous submission to another conference or journal is allowed. 


CONFERENCE PROCEEDINGS: 
The extended abstracts for the Conference will be published by ACM Press
and will be available at the Conference. A selection of the accepted
extended abstracts in their final journal versions will be invited to
appear in a special issue of the Journal of Computational Biology devoted
to RECOMB 98.


NOTIFICATION: 
The conference submissions will be refereed by the program committee. 
Authors will be notified of acceptance or rejection by a letter mailed on
or before December 15, 1997. A final copy of each accepted paper is
required by January 10, 1997. An author of each accepted paper is expected
to attend the Symposium and present the paper; otherwise alternative
arrangements should be made to have the paper presented. 


ABSTRACT PREPARATION:
An abstract should start with a succinct statement of the problem, the
results achieved, their significance and a comparison with previous work.
This material should be understandable to nonspecialists. A technical
exposition directed to the specialist should follow. The length, excluding
cover page and bibliography, should not exceed 10 pages. The manuscript
should be easy to read, preferably using 11 point font size on U.S.
standard 8 1/2 by 11 inch paper.  If authors believe that more details are
necessary to substantiate the claims of the paper, they may include a
clearly marked appendix. An E-mail address for the contact author should
be included.


INVITED SPEAKERS:

Charles Cantor (Boston University)
Thomas Caskey (Merck)
David Cox (Stanford University)
Ron Davis (Stanford University)
Klaus Gubernator (CombiChem)
Joshua Lederberg (Rockfeller University)
Michael Levitt (Stanford University)
David Schwartz (New York University)
John Yates (University of Washington)


CONFERENCE EVENTS

RECOMB 98 will feature 9 invited lectures including the following conference 
events: 

THE STANISLAW ULAM MEMORIAL COMPUTATIONAL BIOLOGY ADDRESS 
awarded by RECOMB to a scientist who has made major contributions 
in the computational aspects of the field. Professor Joshua Lederberg 
of Rockfeller University will deliver the Statislav Ulam Memorial 
Computational Biology Address.

THE DISTINGUISHED BIOLOGY LECTURE 
awarded by RECOMB to a scientist who has made major contributions 
in the biological aspects of the field. Professor Ron Davis 
of Stanford University will deliver the Distinguished Biology Lecture.

THE DISTINGUISHED NEW TECHNOLOGIES LECTURE 
describing emerging, new technologies. Professor David Cox
of Stanford University will deliver the Distinguished New Technologies Lecture.


BEST PAPER BY A YOUNG SCIENTIST AWARD.
This award will be given to the best paper written solely by one or more
recent graduates or students. An abstract is eligible if all authors are
recent graduates (within 2 years from Ph.D.) or full-time students at the
time of submission. This should be indicated in the submission letter. The
program committee may decline to make the award or may split it among
several papers. 


STEERING COMMITTEE: 

Sorin Istrail, RECOMB General Vice-Chair (Sandia National Laboratories)
Richard Karp (University of Washington)
Thomas Lengauer (GMD-SCAI, Germany)
Pavel Pevzner, RECOMB General Chair (University of Southern California) 
Ron Shamir (Tel-Aviv University, Israel)
Michael Waterman, RECOMB General Chair (University of Southern California)


PROGRAM COMMITTEE:

Craig Benham (Mount Sinai School of Medicine)
Gary Benson (Mount Sinai School of Medicine) 
Bonnie Berger (MIT)
Martin Farach (Rutgers University)
Phil Green (University of Washington)
Dan Gusfield  (University of California Davis)
David Haussler (University of California Santa Cruz)
Sorin Istrail (Sandia National Laboratories)
Richard Karp (University of Washington)
Minoru Kanehisa (Kyoto University, Japan)
Eugene Koonin (National Center for Biotechnology Information) 		 
Thomas Lengauer (GMD-SCAI, Germany)
Webb Miller (Pennsylvania State University) 
Gene Myers  (University of Arizona) 
Pavel Pevzner, Program Committee Chair (University of Southern California)
David Searls (SmithKline Beecham)
Ron Shamir (Tel-Aviv University, Israel) 
Terry Speed (University of California Berkeley)
Martin Vingron (German Cancer Center)
Michael Waterman (University of Southern California)


ORGANIZING COMMITTEE:

Craig Benham (Mount Sinai School of Medicine)
Gary Benson, Conference Chair (Mount Sinai School of Medicine)  
Martin Farach (Rutgers University)
Eugene Kolker, Publicity Chair (University of Washington)



Information about local arrangements can be obtained by consulting the
conference web page
    
	http://www.mssm.edu/biomath/recomb98.html
 
or from the Conference Chair:

	     Professor Gary Benson
	Department of Biomathematical Sciences
	          Box 1023
	  The Mount Sinai Medical Center
	  One Gustave L. Levy Place
	   New York, NY 10029-6574
	        (212) 241-5777 phone
                (212) 860-4630 fax
         benson@ecology.biomath.mssm.edu



Sorry, if you get this mail twice.
	   
--------------------------------------------------------------------
Eugene Kolker                                           
Dept of Molecular Biotechnology, Box 357730     Tel: +1-206-685-6941
University of Washington School of Medicine     Fax: +1-206-685-7301
Seattle, WA 98195-7730, USA                     egn@u.washington.edu
     NEW (!)  WEB: http://bozeman.genome.washington.edu/~eugene


From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!rutgers!gatech!nntp.msstate.edu!news.memphis.edu!news.wku.edu!not-for-mail
From: john white <mannwm@wku.edu>
Newsgroups: bionet.software
Subject: Drugnet: A Web-based Survey of Successful Adults Who Use Recreational Drugs
Date: Thu, 11 Sep 1997 15:19:22 -0500
Organization: Western Kentucky Univeristy
Lines: 46
Message-ID: <3418524A.7471@wku.edu>
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Mime-Version: 1.0
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Drugnet: A Web-based Survey of Successful Adults Who Use Recreational
Drugs
Are you successful?
Do you have a stable home life?
Are you a happy adult?
Do you occasionally enjoy the recreational use of Marijuana or other
drugs (e.g., Cocaine, LSD, etc.)?

Past research on drug use has concentrated on drug abusers (i.e., people
in treatment), elementary, high-school, or college students.  We are
conducting a survey to demonstrate the existence of successful adult
drug users in our society.

If you fit the above qualifications, we would like you to take our
survey.  All information is anonymous.  You don't have to e-mail us
*ANYTHING* that carries your e-mail address.  All you have to do is set
your web-browser to:

http://wkuweb1.wku.edu/~drugnet

All you need to take this survey is a little time (approximately 20-30
minutes, depending upon your level of experience with a mouse and
recreational drugs).  All responses will be kept confidential!

This is for REAL!  This is *not* an attempt to identify drug users for
police records.  We are researchers at academic institutions who are
interested in Drug Policy.  If you have any questions about this study,
you may contact us at the address listed below.

If you have taken this survey before, during our pilot study last year,
we'd like for you to take it *again*!.  Based on respondent feedback,
we've added new questions and made other modifications.  So please, tell
us about your expereinces using this newer format.

NOTE:  This survey should work with any web browser that supports forms
and tables.  This includes Netscape 2.0+, Internet Explorer 2.0+, and
similar software.  


	Tom Nicholson, Ph.D.
	John B. White, Ph.D.
	Department of Public Health
	Western Kentucky University
	1 Big Red Way
	Bowling Green, KY 42101
	Voice: 502/745-4797

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!nntp.kreonet.re.kr!xfer.kren.nm.kr!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!worldnet.att.net!newsadm
From: "Naum Burman" <Nick.B@worldnet.att.net>
Newsgroups: bionet.software
Subject: Real Time talking like on  a phone thru the Internet using software or hardware
Date: 11 Sep 1997 19:40:15 GMT
Organization: AT&T WorldNet Services
Lines: 14
Message-ID: <01bcbee9$936ec9a0$2f3174cf@default>
NNTP-Posting-Host: 207.116.49.47
X-Newsreader: Microsoft Internet News 4.70.1155

Dear Friends,
	Yesterday I heard about a new program which uses software or hardware 
( i am not sure which one ).  So you can talk through the internet in real
time like on the phone.  You can also receive phone calls, send and receive
faxes.  And it costs about 
2 dollars per hour.  And I would like to know where I can find this type of
program and how much it works.
	Or if you know a program that is similar to the one described above.
	Thank you and awaiting your response with warm regards.  I would
appreciate if you would send responses to my e-mail address which is
Nick.B@worldnet.att.net.
								Sincerely,
								Julia Burman


From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!europa.clark.net!208.134.241.18!newsfeed.internetmci.com!newsfeed.internetmci.com!194.72.7.126!news-peer.bt.net!btnet!baron.netcom.net.uk!netcom.net.uk!server3.netnews.ja.net!news.ox.ac.uk!lady0266
From: lady0266@ermine.ox.ac.uk (Richard Grant)
Newsgroups: bionet.software
Subject: Re: CCD Video Capture
Date: 11 Sep 1997 16:51:53 GMT
Organization: Oxford University, England
Lines: 18
Message-ID: <5v97j9$6sl$1@news.ox.ac.uk>
References: <green-1109970918260001@jerky.salk.edu>
NNTP-Posting-Host: ermine.ox.ac.uk
X-Newsreader: TIN [version 1.2 PL2]

Tim Green (green@salk.edu) wrote:
: This relates to hardware as well as software, but this was the most
: relevant newsgroup.

<shnip>

Check out http://www.improvision.com/

Utterly Mac-based, personal service, they have a distributor in the US now too.

R


--
Richard P. Grant MA DPhil         rpgrant@molbiol.ox.ac.uk
Nuffield Department of Obstetrics and Gynaecology, University of Oxford.
http://sable.ox.ac.uk/~lady0266   Fax +44 1 865 69141
It's only ones and zeroes.

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!agate!newsgate.cuhk.edu.hk!news.hku.hk!hkupc
From: sw (Your full name)
Newsgroups: bionet.software
Subject: Information on Tox Calc ver 5.0 requested
Date: Thu, 11 Sep 97 16:51:22 GMT
Organization: HKU
Lines: 18
Message-ID: <5v97ng$fc31@hkusud.hku.hk>
NNTP-Posting-Host: p149.du.hku.hk
Summary: Tox Calc ver 5.0 information requested
X-Newsreader: News Xpress 2.0 Beta #0
Keyword: Tox Calc

Dear all,
 
I am currently involving an assessment of outfall locations with
respective to certain criteria. One of which is toxicity assessment,
 
I shall be grateful if any one can provide me information and contact
point for the following software:-
 
ToxCalc Comprehensive Toxicity Data Analysis and Database Software
ver 5.0.
 
Please reply to my e-mail account and thanks in advance for your help
and attention.
 
K.F.Leung
 
E-mail: kfleung@hkucc.hku.hk
 

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!agate!ihnp4.ucsd.edu!news.scripps.edu!jerky.salk.edu!user
From: green@salk.edu (Tim Green)
Newsgroups: bionet.software
Subject: CCD Video Capture
Date: Thu, 11 Sep 1997 09:18:26 -0700
Organization: Salk Institute
Lines: 17
Message-ID: <green-1109970918260001@jerky.salk.edu>
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Mime-Version: 1.0
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Content-Transfer-Encoding: 7bit

This relates to hardware as well as software, but this was the most
relevant newsgroup.

We are interested in purchasing a microscope and CCD video capture system
for neural imaging (in situs and imaging of neurons in culture).  As a
primarily mac based lab, we would prefer a mac based capture card and
software.  Does anyone have any experience/suggestions on available cards
and cameras, distributors in the US and prices?  We have quotes from Leica
and Zeiss, but both have specified Win95 capture cards.

Thanks in advance

Tim Green

-- 
MNL-H
Salk Institute

From owner-software@net.bio.net Wed Sep 10 23:00:00 1997
Path: biosci!agate!ihnp4.ucsd.edu!news1.ucsd.edu!jstrout
From: jstrout@ucsd.edu (Joseph J. Strout)
Newsgroups: bionet.software
Subject: Re: Neural network software
Date: Wed, 10 Sep 1997 20:09:05 -0700
Organization: UCSD
Lines: 15
Message-ID: <jstrout-ya02408000R1009972009050001@news.ucsd.edu>
References: <34171CFF.5E11BD92@sprynet.com>
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In article <34171CFF.5E11BD92@sprynet.com>, ambal@sprynet.com wrote:

>Does anyone know a good source of neural network software that can be
>easily adapted for biological data and forecasting?

I'm not sure what level of modeling you're looking for, but you could
consider CONICAL:  http://www-acs.ucsd.edu/~jstrout/conical/

Regards,
-- Joe

,------------------------------------------------------------------.
|    Joseph J. Strout           Department of Neuroscience, UCSD   |
|    jstrout@ucsd.edu           http://www-acs.ucsd.edu/~jstrout/  |
`------------------------------------------------------------------'

From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
Path: biosci!biosci!not-for-mail
From: Yu Wai Chen <ywc@mrc-lmb.cam.ac.uk>
Newsgroups: bionet.software.xplor,bionet.software,bionet.xtallography
Subject: Update URL of online crystallography tools
Date: 12 Sep 1997 07:17:36 -0700
Organization: MRC Centre for Protein Engineering
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Distribution: world
Message-ID: <341682C8.1FB18239@mrc-lmb.cam.ac.uk>
NNTP-Posting-Host: net.bio.net
Xref: biosci bionet.software:19484 bionet.xtallography:3741

Dear all,

Please note that our online crystallography tools service has now been
relocated again.  The new URL is:

  <http://www.mrc-cpe.cam.ac.uk/people/ubc/ubc.html>

Please update your bookmarks and links accordingly.

Our previous URL's on the hosts:

"laue.biochem.ubc.ca" and "dta.med.harvard.edu" are no longer supported.

-- 
===================================================================
Yu Wai CHEN, Ph.D. ..................  email: ywc@mrc-lmb.cam.ac.uk
 Centre for Protein Engineering,              tel: 44-(1223) 402148
 MRC Centre, Cambridge  CB2 2QH, U.K.         fax: 44-(1223) 402140
 WWW homepage: http://www.mrc-cpe.cam.ac.uk/people/wai.html


From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
Newsgroups: bionet.software,bionet.molec-model
Path: biosci!fcs280s.ncifcrf.gov!cpk-news-feed4.bbnplanet.com!cpk-news-feed1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!baron.netcom.net.uk!netcom.net.uk!uknet!bcc.ac.uk!news
From: Marketa J Zvelebil <marketa@ludwig.ucl.ac.uk>
Subject: Re: protein / predicting 3D-structure perturbation
Message-ID: <3419B76F.2F1C@ludwig.ucl.ac.uk>
Date: Fri, 12 Sep 1997 21:43:11 GMT
Content-Transfer-Encoding: 7bit
Content-Type: text/plain; charset=us-ascii
References: <5v68h9$1scm@moka.ccr.jussieu.fr> <3417734A.78C3C568@teslaNOSPAM.mbi.uclaFNORD.edu>
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Xref: biosci bionet.software:19482 bionet.molec-model:1790

Scott Le Grand wrote:
> 
> Michel PETITJEAN wrote:
> >
> > I have the x,y,z coordinates of a protein in PDB format.
> > One of the residues has an H-bonding with the rest of the protein.
> > Now I replace this residue with an other one which offers no H-bonding.
> > How can I predict the perturbations induced on the 3D-structure ?
> > Is there softwares for that (free or not) ?
> > Thanks.
> 
> There are numerous prediction packages available.  None of them
> have been shown to be of any predictive value whatsoever anywhere
> but within the scientific papers that describe them.  However,
> I'm sure the developers of said packages would insist on
> disagreeing with this statement
> 
> Your best bet at prediction would be to assume the structure
> did not change as a result of the mutation.
> 
> Scott Le Grand

It would depend what kind and how large are the perturbations you
want to measure. Easiest is to model the mutation as you have and
simply minimize the structure and look at local changes. If you want
to go further you can try local dynamics. If you really want to get
deeply into it, with probably very little extra information, you
could try things like how has it effected the charge distribution
around that residue etc. That is all available within insightII
(Biosym).

Marketa


-- 

                  Dr. Marketa J Zvelebil,
Ludwig Institute for Cancer Research, 91 Riding House Street			
                  London W1P 8BT, ENGLAND.				 
       Tel: (44) 0171 878-4012 ,Fax: (44) 0171 878-4040			
              e-mail: marketa@ludwig.ucl.ac.uk	  
          http://www.ludwig.ucl.ac.uk/st/hello.html 
                              *
        "Computers make excellent and efficient servants 
           but I have no wish to serve under them."
               (Spock - The Ultimate Computer)


From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
Path: biosci!bloom-beacon.mit.edu!eru.mt.luth.se!feed1.news.erols.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!baron.netcom.net.uk!netcom.net.uk!server3.netnews.ja.net!is.bbsrc.ac.uk!Andy.Law
From: Andy.Law@bbsrc.ac.uk (Andy Law)
Newsgroups: bionet.software
Subject: Re: Good C compiler for Mac?
Date: Fri, 12 Sep 1997 09:16:41 +0100
Organization: Roslin Institute
Lines: 19
Message-ID: <Andy.Law-ya023480001209970916410001@is.bbsrc.ac.uk>
References: <34165531.566D@interlog.com> <3417ECC9.74518DE8@biokin.com>
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In article <3417ECC9.74518DE8@biokin.com>, Petr Kuzmic <pkuzmic@biokin.com>
wrote:

 >  I don't know about the legality of the following suggestion, but...
 >  there must be a lot of people (like me) with several old versions of
 >  Apple MPW and MetroWerks Code Warrior sitting around.  How about getting
 >  hold (by a license transfer or whatever) of an obsolete copy?  It should
 >  do fine for your student project.

Completely illegal if you are currently using (or intend to use in the
future) the up to date version of the said programs.

Codewarrior Academic is pretty cheap ( approx $100?) and you can get Fortan
compilers as well at an academic discount.

Andy Law
------------------
( Andy.Law@bbsrc.ac.uk )
( Big Nose in Edinburgh )

From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
Newsgroups: bionet.software
Path: biosci!bloom-beacon.mit.edu!thetimes.pixel.kodak.com!news.kodak.com!news-pen-16.sprintlink.net!newsfeed.nysernet.net!news.nysernet.net!206.229.87.50!news-pull.sprintlink.net!news-in-east.sprintlink.net!news.sprintlink.net!Sprint!158.43.192.17!rill.news.pipex.net!pipex!join.news.pipex.net!pipex!server1.netnews.ja.net!server5.netnews.ja.net!leeds.ac.uk!news
From: garyt@bmb.leeds.ac.uk (Gary Sheldon Thompson)
Subject: Re: Good C compiler for Mac?
Message-ID: <3418ECE2.41C6@bmb.leeds.ac.uk>
NNTP-Posting-Host: bmbsgi14.leeds.ac.uk
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    <3417ECC9.74518DE8@biokin.com>
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Petr Kuzmic wrote:
> 
> oxidizer@INTERLOG.COM wrote:
> 
> > I'm looking for a good C
> > compiler for a PowerMac; any suggestions?
> 
> Metrowerks is very easy to use, and it's cheap.  Apple MPW/C seems to me
> more easily interfaced with Fortran tools from various vendors.   If you
> were to integrate a lot of existing Fortran code into you application,
> that would be the only reason I'd at least take a look at MPW.
> 
> I don't know about the legality of the following suggestion, but...
> there must be a lot of people (like me) with several old versions of
> Apple MPW and MetroWerks Code Warrior sitting around.  How about getting
> hold (by a license transfer or whatever) of an obsolete copy?  It should
> do fine for your student project.
> 
> _____________________________________________________________
> Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
> pkuzmic@biokin.com * http://www.biokin.com * 608.256.1269 fax


Also you should note that

1. metrowerks have very reasonable academic rates 70ps
2. Codewarrior comes with MPW on the CD


GARY
-- 
end
*********************************************************************
                                       
 Dr. Gary S. Thompson           Address: 
 Wellcome Postdoctoral Fellow   Biochemistry and Molecular Biology, 
 Sheena Radford's Laboratory    Woodhouse Lane,    
                                University of Leeds,    
 Studying the structure and     Leeds, LS2 9JT.    
 folding of proteins by nmr.    England. 
                         
                                e-mail: garyt@bmb.leeds.ac.uk.
                                tel:    0113 233 3134
                                fax:    0113 233 3167
                              
*********************************************************************

From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!newsfeed.internetmci.com!206.229.87.25!news-peer.sprintlink.net!news.sprintlink.net!Sprint!uunet!in4.uu.net!202.82.1.1!bull.hkstar.net!hkstar2!news
From: "King Kong" <a2403@hkstar.com>
Newsgroups: bionet.software
Subject: !!!!!!!!!Help Me Please!!!!!!!!!!!!
Date: 12 Sep 1997 14:24:06 GMT
Organization: Hong Kong Star Internet Ltd.
Lines: 7
Message-ID: <01bcbf86$b914c400$b9f152ca@kin>
NNTP-Posting-Host: 202.82.241.185
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If you know which software can rec a cd song, (like CDDA)
Please send it to me...
But don't send the CDDA, because my CD-ROM can't use it.
Thanks
My E-Mail address is: a2403@hkstar.com
And my Icq uin is: 2397362


From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
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From: Daniel Schlieper <aeg17@rs3.rrz.uni-koeln.de>
Newsgroups: bionet.software,bionet.molbio.methds-reagnts
Subject: Re: Help Wanted: A free program to draw circular plasmids: for Mac or PC
Followup-To: bionet.software,bionet.molbio.methds-reagnts
Date: 12 Sep 1997 21:15:34 +0200
Organization: Regional Computing Center, University of Cologne
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Xref: biosci bionet.software:19487 bionet.molbio.methds-reagnts:61159

Hello,

if you use Linux or any other kind of Unix, you should try xfig. It is
available at ftp.x.org in /contrib/applications/drawing_tools/xfig for
free. It is just a normal drawing prorgam, but I managed to draw a
very nice plasmidmap in short time.


Best regards, Daniel Schlieper
-- 
Daniel Schlieper                    Institut fuer Biochemie
                                    Zuelpicher Strasse 47
Daniel.Schlieper@Uni-Koeln.De       Universitaet zu Koeln 
Tel.: +49 221 470 6443              D-50674 Koeln


From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
From: Lu.Do@Home.DiVa.nl (L.P.J.J. Noldus)
Newsgroups: bionet.software
Subject: Product Specialist scientific software (DC area)
Date: Fri, 12 Sep 1997 22:04:01 GMT
Organization: Noldus Information Technology b.v.
Reply-To: Lu.Do@Home.DiVa.nl
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Job opening: Product Specialist

Noldus Information Technology Inc., developer of software and
instrumentation for behavioral research, has an immediate opening
for a Product Specialist who will serve as the technical
intermediary between Noldus products and its (new) users. You will
be responsible for a range of activities which help prospects
understand how our products can fulfill their research needs. Your
job will include the following tasks, in order of priority: provide
high-quality sales services for customers by supplying information
and presenting the full range of Noldus products and services,
support Noldus sales efforts through product demonstrations at
scientific conferences or at customers' locations, and support our
direct marketing efforts to promote new products and upgrades.

Required: service-oriented personality; strong verbal and written
communication skills; excellent organizational and interpersonal
skills; initiative, enthusiasm, high-energy and positive attitude; PC
hardware and operating systems knowledge- Problem solving ability;
must be willing to travel.

Mail resume and cover letter to Noldus Information Technology Inc.,
Attn: Human Resources, 6 Pidgeon Hill Drive, Suite 180, Sterling, VA
20165, U.S.A. For any further information, feel free to call Bart van
Roekel at 1-800-355-9541. More information about our company 
can be found on our web site http://www.noldus.com. 


From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
Path: biosci!daresbury!uninett.no!sn.no!Norway.EU.net!EU.net!news.maxwell.syr.edu!news-peer.gsl.net!news-stkh.gip.net!news.gsl.net!gip.net!news3.funet.fi!news.funet.fi!news.helsinki.fi!not-for-mail
From: Dag Stenberg <stenberg@cc.helsinki.fi>
Newsgroups: bionet.software
Subject: Re: CCD Video Capture
Date: 12 Sep 1997 13:57:48 GMT
Organization: University of Helsinki
Lines: 37
Message-ID: <5vbhos$3jp$1@oravannahka.Helsinki.FI>
References: <green-1109970918260001@jerky.salk.edu>
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Tim Green <green@salk.edu> wrote:
> We are interested in purchasing a microscope and CCD video capture system
> for neural imaging (in situs and imaging of neurons in culture).  As a
> primarily mac based lab, we would prefer a mac based capture card and
> software.  Does anyone have any experience/suggestions on available cards
> and cameras, distributors in the US and prices?  We have quotes from Leica
> and Zeiss, but both have specified Win95 capture cards.

We bought our systeme about 5 years ago, so part of the information is
perhaps not up to date. After quite careful consideration and
comparisons, we got:

- Nikon Labophot-2 microscope  (bright-field, dark-field)
- Sony XC77-CE  b/w CCD camera (could not afford the DAGE MTI C72)
- Signal Analytics' IPLab program for the Mac with some extra
modules. This came with a
- Scion LG-3 card, which we equipped with 16 Mb extra memory. NIH Image
for this card came without extra cost.

We have no regrets, and use the system mainly for in situ hybridization
analysis. 

Dag Stenberg
------------------------------------------------------------------
Dag Stenberg     MD PhD                    stenberg@cc.helsinki.fi
Institute of Biomedicine		   tel: int.+358-9-1918532
Department of Physiology                   fax: int.+358-9-1918681
P.O.Box 9        (Siltavuorenpenger 20 J)   
FIN-00014 University of Helsinki,Finland   
        X.400:   /C=FI/A=FUMAIL/P=INET/O=HELSINKI/OU=CC/S=STENBERG/
------------------------------------------------------------------







From owner-software@net.bio.net Thu Sep 11 23:00:00 1997
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From: oba@oba.oba (Obabá)
Newsgroups: bionet.software,bionet.molbio.methds-reagnts
Subject: Help Wanted: A free program to draw circular plasmids: for Mac or PC
Date: Fri, 12 Sep 1997 16:11:19 GMT
Organization: Universidade de Coimbra
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Xref: biosci bionet.software:19486 bionet.molbio.methds-reagnts:61155

Hello Everybody!
As you can see from the title of this post, I need a program
(preferencially free or shareware), that can make diagrams of
circular plasmids.
I would appreciate a lot if someone could point out a site in the
web where I could get such a program.
Thanks in advance!

Angelo Tome'
Center for Neurosciences of Coimbra
Portugal

From owner-software@net.bio.net Fri Sep 12 23:00:00 1997
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From: Scott Le Grand <legrand@teslaNOSPAM.mbi.uclaFNORD.edu>
Newsgroups: bionet.software,bionet.molec-model
Subject: Re: protein / predicting 3D-structure perturbation
Date: Fri, 12 Sep 1997 20:53:21 -0700
Lines: 23
Message-ID: <341A0E31.3447AF3C@teslaNOSPAM.mbi.uclaFNORD.edu>
References: <5v68h9$1scm@moka.ccr.jussieu.fr> <3417734A.78C3C568@teslaNOSPAM.mbi.uclaFNORD.edu> <3419B76F.2F1C@ludwig.ucl.ac.uk>
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Xref: biosci bionet.software:19490 bionet.molec-model:1792

Marketa J Zvelebil wrote:
> It would depend what kind and how large are the perturbations you
> want to measure. Easiest is to model the mutation as you have and
> simply minimize the structure and look at local changes. If you want
> to go further you can try local dynamics. If you really want to get
> deeply into it, with probably very little extra information, you
> could try things like how has it effected the charge distribution
> around that residue etc. That is all available within insightII
> (Biosym).

Unfortunately, the theoretical models behind insightII and all
other force fields out there bear no known resemblance to reality.
An energy minimization will do wonders with removing steric
conflicts as a result of the mutation, but it will do nothing
to assist you in the prediction of genuine structual changes
caused by the mutation.

The recent CASP and CASP II structure prediction competitions provided
the first real opportunities to test these models objectively on
blind data.  No one came out a winner except in their own mind and
that's the hard pill we all ought to swallow, but many won't.

Scott Le Grand, Ph. D.

From owner-software@net.bio.net Fri Sep 12 23:00:00 1997
Path: biosci!agate!hammer.uoregon.edu!cs.uoregon.edu!news.sgi.com!news.maxwell.syr.edu!iagnet.net!144.92.88.12!newsspool.doit.wisc.edu!news.doit.wisc.edu!ebv.oncology.wisc.edu!aiyar
From: aiyar@ebv.oncology.wisc.edu (Ashok Aiyar)
Newsgroups: bionet.molbio.methds-reagnts,bionet.software
Subject: Re: clustal protein alignment with >50 sequences?
Followup-To: bionet.software
Date: 13 Sep 1997 16:16:52 GMT
Organization: Sugden Lab, McArdle Laboratory for Cancer Research, UW-Madison
Lines: 32
Message-ID: <slrn61lf3j.qm1.aiyar@ebv.oncology.wisc.edu>
References: <5vch4f$sd2$1@news.tamu.edu>
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Xref: biosci bionet.molbio.methds-reagnts:61179 bionet.software:19492

On Sat, 13 Sep 1997 00:46:11 GMT,
davesmith@bioch.tamu.edu (davesmith@bioch.tamu.edu) wrote:
>We have 51 different phage and chromosomal sequences of the protein we
>study.  None are more than 200 residues in length.  After an
>exhaustive search of the web, we've been unable to find a program that
>will line up more than 25 proteins at once.  Does anyone know of a way
>to line these up and generate a dendrogram or "family tree" with such
>a large number of individual proteins?

Get the latest version of ClustalW (1.7) or ClustalX (1.5).  They
are available from: ftp://ftp-igbmc.u-strasbg.fr/pub/.  Binaries for
a number of platforms including DOS and MacOS are available from there.

The static arrays used to store alignments (in progress) have been
replaced by dynamically allocated memory.  As a result, there are no
limits on the number or length of sequences that can be aligned - as
long as the computer doesn't run out of memory.  In practical terms,
on a Linux PC with 32 megs of real RAM, and 64 megs of swap space,
I recently aligned 39 sequences that were each approximately 8 kilobases
in length.  The alignment ran for about 3 days, but without any memory 
errors.

I believe that a release of DIALIGN which also uses dynamically
allocated arrays will soon be released by Burkhard Morgenstern and
his collaborators.  DIALIGN is available from: ftp://ariane.gsf.de

Later,
Ashok
-- 
Ashok Aiyar, Ph.D.
McArdle Laboratory for Cancer Research
aiyar@ebv.oncology.wisc.edu

From owner-software@net.bio.net Fri Sep 12 23:00:00 1997
From: cesium@prostar.com (Dennis Mitton)
Newsgroups: bionet.software,bionet.molbio.methds-reagnts
Subject: Re: Help Wanted: A free program to draw circular plasmids: for Mac or PC
Date: Fri, 12 Sep 1997 22:28:22 GMT
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Xref: biosci bionet.software:19491 bionet.molbio.methds-reagnts:61171

Not free but if you can find someone with MS Excel you can make donut
charts and expand the inside to about 90% - makes a very nice plasmid.

On Fri, 12 Sep 1997 16:11:19 GMT, oba@oba.oba (Obabá) wrote:

>Hello Everybody!
>As you can see from the title of this post, I need a program
>(preferencially free or shareware), that can make diagrams of
>circular plasmids.


From owner-software@net.bio.net Fri Sep 12 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!news.maxwell.syr.edu!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!newsfeeds.sol.net!news.pagesat.net!news.itis.com!not-for-mail
From: Petr Kuzmic <pkuzmic@biokin.com>
Newsgroups: bionet.software
Subject: Software available: Biochemical kinetics and equilibria
Date: Sat, 13 Sep 1997 14:42:44 -0500
Organization: BioKin Consulting
Lines: 51
Message-ID: <341AECB4.99A48580@biokin.com>
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_____________________________________________________
              PUBLIC DOMAIN PROGRAM DYNAFIT AVAILABLE

DynaFit is a program for simulation and least-squares
fitting of biochemical kinetic data.  The user enters
the reaction mechanism symbolically, such as this:

; "Slow, tight" inhibition of HIV proteinase
                                            
[mechanism]                                 
   E + S <==> ES     :     k       ks       
   ES ---> E + P     :     kr               
   E + I <==> EI     :     k1      k2       
   EI <==> EJ        :     k3      k4       

The machine then derives the underlying system of 
differential equations (to compute the time-course of
the reaction) or algebraic equations (to compute the 
composision at equilibrium). 

_____________________________________________________
                                        TEST PROBLEMS

The program should be downloaded along with a set of
test examples, all of them based on real experimental
mostly from biochemical kinetics, but the same methods
can be used for other areas of chemistry and biology.

_____________________________________________________
                                              REVIEWS

A reviewer had this to say about DynaFit: "If you do any 
kind of kinetic data analysis as part of your research 
program, be sure to download DynaFit from the BioKin Web 
site."  (HMS Beagle Newsletter "Software Alert", volume
1997 No. 9).

_____________________________________________________
                                                LINKS

http://www.biokin.com/                    BioKin home
http://www.biokin.com/dynafit/index.shtml ... DynaFit

_____________________________________________________
                                           REFERENCES

P. Kuzmic (1996) Anal. Biochem. 237, 260-273.

_____________________________________________________________
Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
pkuzmic@biokin.com * http://www.biokin.com * 608.256.1269 fax

From owner-software@net.bio.net Fri Sep 12 23:00:00 1997
Path: biosci!BIOKIN.COM!pkuzmic
From: pkuzmic@BIOKIN.COM (Petr Kuzmic)
Newsgroups: bionet.software
Subject: Re: Good C compiler for Mac?
Date: 13 Sep 1997 16:03:54 -0700
Organization: BioKin Consulting
Lines: 23
Sender: daemon@net.bio.net
Distribution: world
Message-ID: <341B1C70.9E070177@biokin.com>
NNTP-Posting-Host: net.bio.net

oxidizer@INTERLOG.COM wrote:
> As part of a fourth-year undergraduate reserach project, I need 
> (...snip...) a good C compiler for a PowerMac

Petr Kuzmic wrote:
> How about getting
> hold (by a license transfer or whatever) of an obsolete copy? It should
> do fine for your student project.

Andy Law wrote:
> Completely illegal if you are currently using (or intend to use in the
> future) the up to date version of the said programs.

I guess that would be illegal, wouldn't it...  Just thinking, if I were
an undergraduate student who is faced with a one-time, small programming
project, maybe I would download the trial version of CodeWarrior C/C++
from http://www.metrowerks.com/products/cw/lite/.  You can't include
additional files into projects, but all source files are editable.  It's
a start...

_____________________________________________________________
Petr Kuzmic Ph.D. * BioKin Ltd. * Madison, WI 53708-8336, USA
pkuzmic@biokin.com * http://www.biokin.com * 608.256.1269 fax

From owner-software@net.bio.net Sat Sep 13 23:00:00 1997
Newsgroups: bionet.software,bionet.molbio.methds-reagnts
Path: biosci!rutgers!uwm.edu!news.he.net!newsfeed.direct.ca!Cabal.CESspool!bofh.vszbr.cz!lyra.csx.cam.ac.uk!server1.netnews.ja.net!server5.netnews.ja.net!server3.netnews.ja.net!server4.netnews.ja.net!bris.ac.uk!bath.ac.uk!bspwrb
From: bspwrb@bath.ac.uk (W R Bennett)
Subject: Re: Help Wanted: A free program to draw circular plasmids: for Mac or PC
Organization: School of Biological Sciences, University of Bath, UK
Message-ID: <EGH3Kp.95p.C.amo@bath.ac.uk>
References: <341968b2.24147966@news.mat.uc.pt>
Date: Sun, 14 Sep 1997 00:48:26 GMT
Lines: 17
Xref: biosci bionet.software:19495 bionet.molbio.methds-reagnts:61187

In the referenced article, oba@oba.oba (Obabá) writes:
>Hello Everybody!
>As you can see from the title of this post, I need a program
>(preferencially free or shareware), that can make diagrams of
>circular plasmids.
>I would appreciate a lot if someone could point out a site in the
>web where I could get such a program.
>Thanks in advance!
>
http://www.hytti.uku.fi/~kiviraum/plasmid/plasmid.html

Plasmid Processor. It's by no means perfect, but it's free and it does 
the job.

Cheers,

Bill Bennett

From owner-software@net.bio.net Sat Sep 13 23:00:00 1997
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From: info@pgrs.com
Newsgroups: bionet.software
Subject: WANT A FREE PAGER? LOOK HERE!
Date: 13 Sep 97 22:08:41 GMT
Organization: PAGERS
Lines: 38
Message-ID: <341b0ee9.0@news.west-tech.com>
NNTP-Posting-Host: 165.113.201.24


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From owner-software@net.bio.net Sat Sep 13 23:00:00 1997
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From: Mike Tait <ay10@dial.pipex.com>
Newsgroups: bionet.software,bionet.microbiology,sci.bio.microbiology
Subject: Bacterial Growth 3 is a winner in the 1997 ToolBook Interactive awards
Date: Sun, 14 Sep 1997 23:08:05 -0700
Organization: Scotcal Software
Lines: 22
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Xref: biosci bionet.software:19498 bionet.microbiology:10992

Scotcal is pleased to announce that Bacterial Growth 3 is a winner in
the 1997 ToolBook Interactive awards.

For those microbiology teachers who are unfamiliar with this
"outstanding" (according to the judges!) educational software, see the
Bacterial Growth 3 Web pages for more information:

http://www.demon.co.uk/scotcal/growth3/

There is a free downloadable demo version there.

--------------------------------------------------
Dr Mike Tait
Scotcal Software
34A Watson Street, Aberdeen AB25 2QL, Scotland, UK
Telephone: +44-(0)1224-620040
Facsimile: +44-(0)1224-620040
E-mail:    scotcal@dial.pipex.com
WWW:       http://www.demon.co.uk/scotcal/
--------------------------------------------------



From owner-software@net.bio.net Sat Sep 13 23:00:00 1997
Path: biosci!ACCEFYN.ORG.CO!agarcia
From: agarcia@ACCEFYN.ORG.CO (Alexander Garcia Castro)
Newsgroups: bionet.software
Subject: Re: Help Wanted: A free program to draw circular plasmids: for Mac or PC
Date: 13 Sep 1997 21:13:40 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 42
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Distribution: world
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References: <EGH3Kp.95p.C.amo@bath.ac.uk>
NNTP-Posting-Host: net.bio.net

Plasmid Processor is a simple tool for plasmid presentation for
scientific and educational  purposes. It features both circular and
linear DNA, user defined restriction sites, genes and multiple cloning
site. In addition you can manipulate plasmid by inserting and deleting
fragments. Created drawings can be copied to clipboard or saved to disk
for later use. Printing from within program is also supported.
For further information please contact the authors by e-mail,
plasmid@uku.fi.

Visit Plasmid Processor homepage at
http://www.uku.fi/~kiviraum/plasmid/plasmid.html

Programming team: T. Kivirauma, P. Oikari and J. Saarela.


Plasmid Processor is freeware, so you can use and distribute it freely.

Hope it helps.
W R Bennett wrote:

> In the referenced article, oba@oba.oba (Obab=E1) writes:
> >Hello Everybody!
> >As you can see from the title of this post, I need a program
> >(preferencially free or shareware), that can make diagrams of
> >circular plasmids.
> >I would appreciate a lot if someone could point out a site in the
> >web where I could get such a program.
> >Thanks in advance!
> >
> http://www.hytti.uku.fi/~kiviraum/plasmid/plasmid.html
>
> Plasmid Processor. It's by no means perfect, but it's free and it doe=
s
>
> the job.
>
> Cheers,
>
> Bill Bennett




From owner-software@net.bio.net Sat Sep 13 23:00:00 1997
Path: biosci!agate!newsfeed.kornet.nm.kr!news.maxwell.syr.edu!news-was.dfn.de!news-fra1.dfn.de!news-ge.switch.ch!serra.unipi.it!mikasa.iol.it!news
From: "Alex P&P" <alexpo@iol.it>
Newsgroups: bionet.software
Subject: NON LEGFGERTRE
Date: 14 Sep 1997 22:30:27 GMT
Organization: Italia Online
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NNTP-Posting-Host: 195.210.68.85
X-Newsreader: Microsoft Internet News 4.70.1157

PRO

From owner-software@net.bio.net Sun Sep 14 23:00:00 1997
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From: prcjas01@scilab.uct.ac.za (JASON PURCELL)
Newsgroups: alt.comp.shareware,bionet.software
Subject: FAX software
Date: Mon, 15 Sep 1997 13:32:26
Organization: University of Cape Town
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X-Newsreader: Trumpet for Windows [Version 1.0 Rev A]

I am looking for a shareware program that does faxing.

Please e-mail a copy to me if you have one, but only if the program is smaller 
than 4megs. Also, don't send me a program that runs on Win95 or WinNT.

Thank you.


"FOOLS RUSH IN WHERE ANGELS FEAR TO TREAD."




From owner-software@net.bio.net Sun Sep 14 23:00:00 1997
Path: biosci!daresbury!uninett.no!sn.no!www.nntp.primenet.com!globalcenter1!news.primenet.com!nntp.primenet.com!newsfeed.direct.ca!News1.Vancouver.iSTAR.net!news.istar.net!van-bc!news1.istar.ca!not-for-mail
From: "TJ Snider" <timsn@istar.ca>
Newsgroups: bionet.software
Subject: Re: Good C compiler for Mac?
Date: 14 Sep 97 18:08:17 -0700
Organization: iSTAR Internet Incorporated
Lines: 23
Message-ID: <B041D898-213B1@204.191.155.168>
References: <341B1C70.9E070177@biokin.com>
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>
>I guess that would be illegal, wouldn't it...  Just thinking, if I were
>an undergraduate student who is faced with a one-time, small programming
>project, maybe I would download the trial version of CodeWarrior C/C++
>from http://www.metrowerks.com/products/cw/lite/.  You can't include
>additional files into projects, but all source files are editable.  It's
>a start...
>

I believe MetroWerks also has a educational discount version and an intro
to
C++ on the Mac book that is quite cheap...

Check out www.metrowerks.com and
http://www.metrowerks.com/products/how_to_buy/academic.html

Enjoy!

TJ





From owner-software@net.bio.net Sun Sep 14 23:00:00 1997
Path: biosci!agate!newsgate.duke.edu!nntprelay.mathworks.com!europa.clark.net!204.253.208.40!insync!news.insync.net
From: FaxMail@ElectraSoft.com (Bill Krahmer)
Newsgroups: alt.comp.shareware,bionet.software
Subject: Re: FAX software
Date: Mon, 15 Sep 1997 21:37:21 GMT
Organization: ElectraSoft
Lines: 40
Message-ID: <5vk9uo$rqu$1@synthemesc.insync.net>
References: <prcjas01.111.000D8ACA@scilab.uct.ac.za>
Reply-To: FaxMail@ElectraSoft.com
NNTP-Posting-Host: 206.222.164.122
X-Newsreader: Forte Free Agent 1.0.82

prcjas01@scilab.uct.ac.za (JASON PURCELL) wrote:

If you want to try the most powerful and fastest send/receive fax
program on the market today, go to the www-page listed below and try
FaxMail for Windows 3.xx/95 or FaxMail Network for Windows
NT/95/Win32s for FREE.

You can type-in or import up to 999 name and phone numbers into each
FaxBook (Phone Book) and fax to the whole group at once:-)

The FaxMail Convert to Fax will convert to a fax at the rate of 1 page
per second.

If you can print, you can fax.

All the Fax Machines in the world are your printers with FaxMail for
Windows.


>I am looking for a shareware program that does faxing.

>Please e-mail a copy to me if you have one, but only if the program is smaller 
>than 4megs. Also, don't send me a program that runs on Win95 or WinNT.

>Thank you.


>"FOOLS RUSH IN WHERE ANGELS FEAR TO TREAD."




         Kind Regards, 
         Bill Krahmer, ElectraSoft

 E-Mail: FaxMail@ElectraSoft.com  or  jonk@blkbox.com
 Get newest version of FaxMail for Windows or FaxMail Network for NT, free:
 www-page: http://www.ElectraSoft.com/  or  http://www.blkbox.com/~jonk/
 Author member of Association of Shareware Professionals (ASP) 


From owner-software@net.bio.net Sun Sep 14 23:00:00 1997
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From: kaifr@uni-tuebingen.de (Dr. Kai-Uwe Froehlich)
Newsgroups: bionet.software,bionet.molbio.methds-reagnts
Subject: Re: Help Wanted: A free program to draw circular plasmids: for Mac or PC
Date: Mon, 15 Sep 1997 11:59:14 +0200
Organization: Phys.-chem. Institut, Universitaet Tuebingen
Lines: 58
Message-ID: <kaifr-1509971159140001@stremob.pci.chemie.uni-tuebingen.de>
References: <341968b2.24147966@news.mat.uc.pt>
NNTP-Posting-Host: stremob.pci.chemie.uni-tuebingen.de
Xref: biosci bionet.software:19502 bionet.molbio.methds-reagnts:61204

In article <341968b2.24147966@news.mat.uc.pt>, oba@oba.oba (Obabá) wrote:

> Hello Everybody!
> As you can see from the title of this post, I need a program
> (preferencially free or shareware), that can make diagrams of
> circular plasmids.
> I would appreciate a lot if someone could point out a site in the
> web where I could get such a program.
> Thanks in advance!
> 
> Angelo Tome'
> Center for Neurosciences of Coimbra
> Portugal

Hi Angelo,

I have written a plasmid drawing program for the Macintosh which I 
have released as Freeware. It allows to draw circular or linear maps. 
It was originally intended for our lab use, so it is anything but polished. 
It converts lists of restriction sites and fragment/gene positions into 
Postscript files.

Its weak points in short
- It is a Hypercard stack, so you need Hypercard to run it (luckily, speed
is no problem, there are no processor intensive steps involved)
- The output are Postscript files in Illustrator format. To view and to
further edit the picture (which you will have to, see below), you need
either Adobe Illustrator, or the Shareware EPStoPICT, which produces a
fully editable, object oriented PICT version of the graphics.
- The program does not care for overlapping labels, so in most cases you
must do some fine-tuning 

On the other hand, the program
- allows "electronic cloning", so you can quickly construct new plasmids
from those already entered in the program
- can draw all plasmids at the same size, but also using the same (or any
you want) scale (that was the primary reason for me to write the program,
most commercial programs  had (still have?) no way to specify the drawing
scale (except by different magnification in the page setup)
- draws linear and circular maps, allows borders of various widths and
fills of grays, arrows...
- Output quality is great, thanks to Postscript
- The price is right

For a more detailed description, including screen shots of the output
graphics,  see
<http://yeamob.pci.chemie.uni-tuebingen.de/Archiv/PlasmidMaker.html>

and that is also the place to download the stack:
<http://yeamob.pci.chemie.uni-tuebingen.de/Archiv/Plasmid-Maker.hqx>

(BTW, there is also a stack for the organization of plasmid/strain
collections available)

Kai
-----------------------------------------------------------------------
Dr. Kai-Uwe Fröhlich, Physiologisch-chemisches Institut, 
Hoppe-Seyler-Str. 4, 76072 Tübingen, Germany

From owner-software@net.bio.net Sun Sep 14 23:00:00 1997
Path: biosci!AMBER.BIOLOGY.GATECH.EDU!william
From: william@AMBER.BIOLOGY.GATECH.EDU (William S. Hayes)
Newsgroups: bionet.software
Subject: UPDATE Conf. Ann.: Gene Discovery in silico, Atlanta, Nov 6-9
Date: 15 Sep 1997 13:54:36 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 243
Sender: daemon@net.bio.net
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NNTP-Posting-Host: net.bio.net

			
	
	GEORGIA TECH INTERNATIONAL CONFERENCE IN BIOINFORMATICS

			GENE DISCOVERY IN SILICO
                         
			  NOVEMBER 6 - 9, 1997

                                ATLANTA

The focus of the conference is on gene identification 
and prediction of protein function using computer methods.


SPONSORS: 

Georgia Tech College of Science
Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Tech
SmithKline Beecham
Gene Pro, Inc.
Glaxo-Wellcome
 

DATES:

     Deadline for poster abstracts submission:
          October 3, 1997

     Early registration ends:
          October 9, 1997 

Conference schedule:

     Registration opens at 6:00pm on Thursday, November 6,
          (with the reception at 8:00pm).
     The program starts 8:00am Friday, November 7 
          and ends at noon Sunday, November 9.


LOCATION:

     The conference will be held at
     Renaissance Atlanta Hotel Downtown  
     located near the center of 1996 Olympic development,
     close to Fox Theatre & Georgia Tech  
      
     
AGENDA:

     The conference agenda includes plenary talks 
     (45 minutes for each talk and discussion)
     as well as poster sessions.


PLENARY SPEAKERS:

(WWW pages now contain the titles and abstracts of the presentations)

Stephen Altschul       NCBI/NIH, Bethesda, MD
Geoff Barton	       University of Oxford, Oxford, UK
Peer Bork	       EMBL, Heidelberg & MDC, Berlin, Germany
Mark Borodovsky	       Georgia Institute of Technology, Atlanta, GA
Soren Brunak	       Technical University of Denmark, Copenhagen, Denmark
Philipp Bucher	       ISREC, Lausanne, Switzerland
Jean-Michel Claverie   Structural & Genetic Information, CNRS, Marseille, France
Jim Fickett	       SmithKline Beecham, King of Prussia, PA
Terry Gaasterland      Argonne National Lab & University of Chicago, Chicago, IL
Michael Gribskov       San Diego Supercomputer Center, San Diego, CA
Roderic Guigo	       Insitute Municipal d'Investigcio Medica, Barcelona, Spain
Steven Henikoff	       Fred Hutchinson Cancer Research Center, Seattle, WA
Sam Karlin	       Stanford University, Stanford, CA
Anthony Kerlavage      The Institute for Genomic Research, Rockville, MD
Eugene Koonin	       NCBI/NIH, Bethesda, MD
Pavel Pevzner	       University of Southern California, Los-Angeles, CA
Steven Salzberg	       Johns Hopkins University, Baltimore, MD
Victor Solovyev        Amgen, Inc., Thousand Oaks, CA, 
Gary Stormo	       University of Colorado, Boulder, CO
Michael Zhang	       Cold Spring Harbour Lab, Long Island, NY


STEERING & PROGRAM COMMITTEE:

Mark Borodovsky, Co-Chair, 	Georgia Tech
Soren Brunak			Technical University of Denmark 
Jim Fickett			SmithKline Beecham 
Eugene Koonin, Co-Chair, 	NCBI/NIH 
                 

GEORGIA TECH ORGANIZING COMMIT