From owner-biofilms@hgmp.mrc.ac.uk Sun Jun 22 08:39:31 2003 Return-Path: X-Original-To: biofilms-outgoing Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id 9BA037D264 for ; Sun, 22 Jun 2003 08:39:31 +0100 (BST) X-Original-To: biofilms-list@hgmp.mrc.ac.uk Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 3955D7D260 for ; Sun, 22 Jun 2003 08:39:31 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 60001) id C018F7D264; Sun, 22 Jun 2003 08:39:30 +0100 (BST) To: biofilms@net.bio.net Newsgroups: bionet.microbiology.biofilms From: TOPFROG0@aol.com Subject: Biofilm and Catheters Date: 21 Jun 2003 17:06:29 +0100 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: <191.1b917e9e.2c25dc7b@aol.com> Sender: owner-biofilms@hgmp.mrc.ac.uk Precedence: bulk June 21, 2003 Are there any antibiotics that have shown to be somewhat successful in penetrating or destroying Biofilm? I am interested in finding studies that have been or are in progress addressing Biofilm distruction and In-Line catheters. Thanks for your help. Regards, John Cruz Topfrog0@aol.com --- ------------------------------------------------------------------- To reply to the group as well as to the originator, make sure that the address biofilms@net.bio.net is included in the "To:" field. See the BIOFILMS homepage at http://www.im.dtu.dk/biofilms for info on how to (un)subscribe and post to the Biofilms newsgroup. From owner-biofilms@hgmp.mrc.ac.uk Thu Jun 26 21:02:39 2003 Return-Path: X-Original-To: biofilms-outgoing Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with SMTP id D69417D301 for ; Thu, 26 Jun 2003 21:02:38 +0100 (BST) X-Original-To: biofilms-list@hgmp.mrc.ac.uk Received: from localhost (localhost [127.0.0.1]) by mercury.hgmp.mrc.ac.uk (Postfix) with ESMTP id 73B277D304 for ; Thu, 26 Jun 2003 21:02:38 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 60001) id 96D5D7D301; Thu, 26 Jun 2003 21:02:37 +0100 (BST) To: biofilms@net.bio.net Newsgroups: bionet.microbiology.biofilms From: ryan_j@erc.montana.edu ("Ryan Jordan") Subject: RE: Biofilm and Catheters Date: 22 Jun 2003 15:02:49 +0100 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: <000e01c338c6$f2bbf470$094a6441@cytergy1> References: <191.1b917e9e.2c25dc7b@aol.com> Sender: owner-biofilms@hgmp.mrc.ac.uk Precedence: bulk > Are there any antibiotics that have shown to be somewhat successful in > penetrating or destroying Biofilm? I am interested in finding studies that > have been or are in progress addressing Biofilm distruction and In-Line > catheters. Hi John: When we've looked at central venous catheters, stents, etc. with S. epi and S. aureus biofilms, we've found cipro and vanco to be reasonable for penetrating the biofilm; however, they still seem to leave a persister population that has a tendency to reseed the biofilm. Our recommended strategy has not been to find a magic anti-biofilm antibiotic so to speak (that would be nice, and they are in development, but it'll probably be awhile before they become FDA approved), but to design a dosing strategy to deal with the persisters. Best Regards, Ryan --- Ryan Jordan Biofilm science training online at: http://www.Cytergy.com/ --- ------------------------------------------------------------------- To reply to the group as well as to the originator, make sure that the address biofilms@net.bio.net is included in the "To:" field. See the BIOFILMS homepage at http://www.im.dtu.dk/biofilms for info on how to (un)subscribe and post to the Biofilms newsgroup.