From owner-bio-matrix@net.bio.net Wed Feb 01 22:00:00 1995 Path: biosci!bcm!cs.utexas.edu!not-for-mail From: marchaa@agric.nsw.gov.au (A.Marchant) Newsgroups: bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.genbank,bionet.molbio.methds-reagnts Subject: searches and sequence comparisons - how to do? Date: 1 Feb 1995 22:53:03 -0600 Organization: UTexas Mail-to-News Gateway Lines: 21 Sender: nobody@cs.utexas.edu Message-ID: NNTP-Posting-Host: news.cs.utexas.edu Xref: biosci bionet.molbio.bio-matrix:536 bionet.molbio.embldatabank:436 bionet.molbio.evolution:2390 bionet.molbio.genbank:1910 bionet.molbio.methds-reagnts:23843 Could someone please tell me how to go about finding and comparing the sequences of homologous genes from different organisms, in the sequence databases? What I would like to do is to find published sequences of gene X from different organisms, line them up, and identify conserved regions. Specifically, I am interested in the internal transcribed spacer region of ribosomal DNA - a lot of work has been done on this region, from lots of different organisms, so perhaps there is a recent published article which compares the sequences found from very different taxa. If anyone knows of such (or, better still, has written it!), could they tell me about it, please? Please E-mail replies to me. Thanks, Adam Marchant. marchaa@agric.nsw.gov.au From owner-bio-matrix@net.bio.net Wed Feb 01 22:00:00 1995 Path: biosci!adam.cc.sunysb.edu!news.sprintlink.net!howland.reston.ans.net!news.moneng.mei.com!uwm.edu!lll-winken.llnl.gov!enews.sgi.com!decwrl!tribune.usask.ca!quartz.ucs.ualberta.ca!unixg.ubc.ca!leblanc From: leblanc@unixg.ubc.ca (Heidi N LeBlanc) Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Subject: Re: controversies & ethics Followup-To: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Date: 2 Feb 1995 17:45:59 GMT Organization: University of British Columbia, Vancouver, B.C., Canada Lines: 9 Message-ID: <3gr5on$amt@nnrp.ucs.ubc.ca> References: <3gk3au$pdp@rebecca.albany.edu> <3gm7u9$t5e@nntp1.u.washington.edu> NNTP-Posting-Host: interchg.ubc.ca X-Newsreader: TIN [version 1.2 PL2] Xref: biosci bionet.molbio.ageing:1224 bionet.molbio.bio-matrix:537 bionet.molbio.embldatabank:439 bionet.molbio.evolution:2394 bionet.molbio.gdb:285 bionet.molbio.genome-program:1148 bionet.molbio.hiv:865 bionet.molbio.rapd:954 bionet.molbio.yeast:2287 bionet.molbio.gene-linkage:519 One of the problems isn't so much what we *do* with biotechnology, as how what we do is generally perceived. We as scientists think "Oh, what a clever idea, putting an arctic fish gene into strawberries". Non-scientists, with whatever level of education, often seem to think this is just monstrous. The issue might not really be whether what we are doing is ethical, or whether the ethics are unique to biotech, but rather that the level of tinkering we can achieve is vaguely felt to be just plain unnatural. The ethical problems might really be PR problems, and no less real for that. From owner-bio-matrix@net.bio.net Thu Feb 02 22:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!swiss.ans.net!emi.com!pauling.wadsworth.org!rebecca!labonnes From: labonnes@csc.albany.edu (S. LaBonne) Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Subject: Re: controversies & ethics Date: 2 Feb 1995 16:43:49 GMT Organization: University at Albany, SUNY Lines: 34 Message-ID: <3gr245$i9p@rebecca.albany.edu> References: <3gm7u9$t5e@nntp1.u.washington.edu> <3gml85$fb5@rebecca.albany.edu> NNTP-Posting-Host: freia.albany.edu Xref: biosci bionet.molbio.ageing:1226 bionet.molbio.bio-matrix:538 bionet.molbio.embldatabank:440 bionet.molbio.evolution:2395 bionet.molbio.gdb:286 bionet.molbio.genome-program:1152 bionet.molbio.hiv:866 bionet.molbio.rapd:955 bionet.molbio.yeast:2298 bionet.molbio.gene-linkage:522 In article , Howard M. Bomze wrote: > Steve Bonne has been saying that there are no new ethical >considerations for agricultural biotechnologies. However, he has been >missing one very important one, that is the possibility of an engineered >gene to be transfered to a different species. The transgenic plant not >only has the sequences of the desired gene, it also contains the >sequences which are necesary to insert the gene into the genome. So a >question which must be looked at is this: If a gene for herbicide >resistance has been put into a corn plant so that that herbicide can be >used to kill all of the crab grass in the corn field, what happens if >the gene is transfered to the crab grass? Is there an _ethical_ problem here? I guess I can parse this as meaning, "if we failed to be concerned about this possibility and released the engineered corn without satisfying ourselves that it won't happen, we would be behaving unethically". Certainly I agree. Since comparable transfers of desired traits have been performed by selective breeding since the Neolithic (not to mention that horizontal gene transfers occur all the time in nature), I still don't see the _qualitatively_ new ethical considerations that you seem to think exist here. (Introducing rabbits into Australia is a good pre-biotechnology example of failing to anticipate massive undesired consequences of an environmental manipulation.) Don't get me wrong- we clearly need to start thinking a lot more seriously about the potential undesired impacts of _all_ new technologies. I just think that to single out biotechnology as some kind of special case borders on superstition. -- Steve LaBonne *********************** (labonnes@csc.albany.edu) "It can never be satisfied, the mind, never." - Wallace Stevens From owner-bio-matrix@net.bio.net Thu Feb 02 22:00:00 1995 Path: biosci!agate!newsxfer.itd.umich.edu!gatech!swiss.ans.net!emi.com!pauling.wadsworth.org!rebecca!labonnes From: labonnes@csc.albany.edu (S. LaBonne) Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Subject: Re: controversies & ethics Date: 2 Feb 1995 21:41:47 GMT Organization: University at Albany, SUNY Lines: 21 Message-ID: <3grjir$n5d@rebecca.albany.edu> References: <3gm7u9$t5e@nntp1.u.washington.edu> <3gr5on$amt@nnrp.ucs.ubc.ca> NNTP-Posting-Host: bathsheba.albany.edu Xref: biosci bionet.molbio.ageing:1227 bionet.molbio.bio-matrix:539 bionet.molbio.embldatabank:442 bionet.molbio.evolution:2397 bionet.molbio.gdb:287 bionet.molbio.genome-program:1154 bionet.molbio.hiv:867 bionet.molbio.rapd:956 bionet.molbio.yeast:2301 bionet.molbio.gene-linkage:523 In article <3gr5on$amt@nnrp.ucs.ubc.ca>, Heidi N LeBlanc wrote: >One of the problems isn't so much what we *do* with biotechnology, as how >what we do is generally perceived. We as scientists think "Oh, what a >clever idea, putting an arctic fish gene into strawberries". >Non-scientists, with whatever level of education, often seem to think >this is just monstrous. The issue might not really be whether what we >are doing is ethical, or whether the ethics are unique to biotech, but >rather that the level of tinkering we can achieve is vaguely felt to be >just plain unnatural. The ethical problems might really be PR problems, >and no less real for that. I quite agree, and my fear is that we needlessly _exacerbate_ these PR problems if we single out biotechnology for the kind of special treatment exemplified by the proposed course that started this discussion. Then naturally laypeople conclude, "Gee, even the scientists think this stuff is especially problematical, so we _certainly_ should be worried". -- Steve LaBonne *********************** (labonnes@csc.albany.edu) "It can never be satisfied, the mind, never." - Wallace Stevens From owner-bio-matrix@net.bio.net Thu Feb 02 22:00:00 1995 Newsgroups: bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.genbank,bionet.molbio.methds-reagnts Path: biosci!bcm!cs.utexas.edu!swrinde!howland.reston.ans.net!agate!dog.ee.lbl.gov!news.cs.utah.edu!emba-news.uvm.edu!sadye!aquilla From: aquilla@salus.med.uvm.edu (Tracy Aquilla) Subject: Re: searches and sequence comparisons - how to do? Message-ID: Sender: news@emba.uvm.edu Organization: EMBA Computer Facility, University of Vermont X-Newsreader: VersaTerm Link v1.1 References: Date: Fri, 3 Feb 1995 14:01:31 GMT Lines: 28 Xref: biosci bionet.molbio.bio-matrix:540 bionet.molbio.embldatabank:443 bionet.molbio.evolution:2400 bionet.molbio.genbank:1912 bionet.molbio.methds-reagnts:23956 In Article , marchaa@agric.nsw.gov.au (A.Marchant) wrote: >Could someone please tell me how to go about finding and comparing the >sequences of homologous genes from different organisms, in the sequence >databases? > >What I would like to do is to find published sequences of gene X from >different organisms, line them up, and identify conserved regions. > >Specifically, I am interested in the internal transcribed spacer region of >ribosomal DNA - a lot of work has been done on this region, from lots of >different organisms, so perhaps there is a recent published article which >compares the sequences found from very different taxa. If anyone >knows of such (or, better still, has written it!), could they tell me >about it, please? > >Please E-mail replies to me. > > Thanks, Adam Marchant. > marchaa@agric.nsw.gov.au You need to get the help files for the BLAST and Retreive servers at NCBI. You may also find NEntrez useful. This information is available via anonymous FTP. FTP to ncbi.nlm.nih.gov and login as anonymous, using your email address as a password. Browse through the directories for BLAST and download the help file. Do the same for Retreive and Entrez (Network). If you need more help, email me. Tracy From owner-bio-matrix@net.bio.net Fri Feb 03 22:00:00 1995 Path: biosci!hubcap.clemson.edu!biosci!rutgers!uwm.edu!vixen.cso.uiuc.edu!howland.reston.ans.net!swiss.ans.net!emi.com!pauling.wadsworth.org!rebecca!labonnes From: labonnes@csc.albany.edu (S. LaBonne) Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.gene-linkage,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast Subject: Re: controversies & ethics Date: 31 Jan 1995 01:21:34 GMT Organization: University at Albany, SUNY Lines: 39 Message-ID: <3gk3au$pdp@rebecca.albany.edu> References: NNTP-Posting-Host: freia.albany.edu Xref: biosci bionet.molbio.ageing:1230 bionet.molbio.bio-matrix:541 bionet.molbio.embldatabank:444 bionet.molbio.evolution:2403 bionet.molbio.gdb:288 bionet.molbio.gene-linkage:529 bionet.molbio.genome-program:1158 bionet.molbio.hiv:869 bionet.molbio.rapd:957 bionet.molbio.yeast:2304 In article , Phandaal wrote: >I've been asked to give a lecture to upper-division college students on >the controversies and ethical considerations in producing transgenic >organisms, especially transgenic plants. It's been a while since I gave >this lecture, and so I was wondering if anybody had any good examples of >controversies or ethical considerations that I could incorporate into the >talk. > >Two I can think of off-hand are: > >1) introducing insecticidal proteins (such as the Bacillus thuringiensis >protein) into plants may create resistant insect populations (under the >force of heavy selection pressure), which could then overrun the resistant >plants and make worthless the efforts by conventional growers who *use* Bt >protein as a topical pesticidal spray. > >2) altering fatty acid metabolism in oil-crops (like canola) so that they >produce oils found chiefly in palm and coconut could severely damage the >palm oil and coconut oil industries in Third World countries... thus >severely depressing the economies of these already struggling countries. My problem with these examples is that I see nothing about them that is unique to transgenic technology. Similar sorts of problems are raised all the time by "conventional" technologies, including very ancient ones like selective breeding. An analogue to 1 is simply overuse of pesticides (or antibiotics for that matter), which can render them worthless in the way you describe. And 2 in no way raises ethical issues different from, say, starting a palm oil industry in Key West, possibly after selective breeding of oil palms to produce strains that give high yields there. Indeed, I doubt that there _are_ any ethical issues which depend _specifically_ on agricultural use of biotechnology as opposed to agricultural technologies in general. -- Steve LaBonne *********************** (labonnes@csc.albany.edu) "It can never be satisfied, the mind, never." - Wallace Stevens From owner-bio-matrix@net.bio.net Sat Feb 04 22:00:00 1995 Path: biosci!bcm!cs.utexas.edu!swrinde!news.uh.edu!uuneo.neosoft.com!Starbase.NeoSoft.COM!mckee From: mckee@starbase.neosoft.com (George McKee) Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Subject: Re: controversies & ethics Followup-To: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Date: 5 Feb 1995 15:25:32 GMT Organization: NeoSoft Internet Services +1 713 968 5800 Lines: 24 Message-ID: <3h2qlc$d6o@uuneo.neosoft.com> References: <3gk3au$pdp@rebecca.albany.edu> <3gm7u9$t5e@nntp1.u.washington.edu> NNTP-Posting-Host: starbase.neosoft.com X-Newsreader: TIN [version 1.2 PL2] Xref: biosci bionet.molbio.ageing:1236 bionet.molbio.bio-matrix:543 bionet.molbio.embldatabank:445 bionet.molbio.evolution:2412 bionet.molbio.gdb:290 bionet.molbio.genome-program:1164 bionet.molbio.hiv:871 bionet.molbio.rapd:960 bionet.molbio.yeast:2314 bionet.molbio.gene-linkage:530 Howard M. Bomze (hb10+@andrew.cmu.edu) wrote: : Steve Bonne has been saying that there are no new ethical : considerations for agricultural biotechnologies. However, he has been : missing one very important one, that is the possibility of an engineered : gene to be transfered to a different species. The transgenic plant not : only has the sequences of the desired gene, it also contains the : sequences which are necesary to insert the gene into the genome. This is one of those "ethical" problems that are really biological problems in disguise. Injecting new genes into the genomes of other organisms is precisely what retroviruses such as HIV have been doing for eons longer than biologists. To consider genetic engineering per se to be unethical is the same as considering crossbreeding unethical. The ethical considerations come into play when the new variety, however it was created, is being considered for introduction into the ecosystem. Introducing the gypsy moth into North America as a silk producer was far more disastrous than any frost-free tomato is likely to be. - George McKee -- Internet: mckee@neosoft.com Voice: +1 713 890 8122 From owner-bio-matrix@net.bio.net Sun Feb 05 22:00:00 1995 Path: biosci!PHRI.NYU.EDU!inamine From: inamine@PHRI.NYU.EDU (Gordon Inamine) Newsgroups: bionet.molbio.bio-matrix Subject: Re: * A SWEETHEART FOR VALENTINE'S * Date: 6 Feb 1995 10:04:49 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 1 Sender: daemon@net.bio.net Distribution: world Message-ID: <9502061804.AA01535@thymine.phri.nyu.edu> NNTP-Posting-Host: net.bio.net no commercial messages please From owner-bio-matrix@net.bio.net Mon Feb 06 22:00:00 1995 Path: biosci!daresbury!sunsite.doc.ic.ac.uk!dundee.ac.uk!pathol4 From: (k.c.breen@dundee.ac.uk) Newsgroups: bionet.molbio.bio-matrix Subject: Research Studentship Followup-To: bionet.molbio.bio-matrix Date: 6 Feb 1995 17:45:52 GMT Organization: The University, Dundee, DD1 4HN, Scotland, UK. Lines: 34 Distribution: world Message-ID: <3h5n8g$n7p@dux.dundee.ac.uk> NNTP-Posting-Host: pathol4.medschool.dundee.ac.uk POSTGRADUATE STUDENTSHIP IN PHARMACOLOGY Applications are invited for a postgraduate studentship, funded by the Association for International Cancer Research, in a multi-disciplinary neuroglycobiology laboratory located in the Department of Pharmacology, University of Dundee. The 3 year studentship will examine the molecular biology of glycosyltransferase enzymes and the functional results of their altered expression in tumor cell lines. Applications are invited from candidates who expect to gain a first or upper-second class degree and although experience in the techniques of molecular biology would be advantageous, training will be provided where necessary. Ninewells Hospital Medical School is situated on the Tay estuary and is surrounded by beautiful countryside which provides excellent opportunities for a variety of outdoor activities. The cost of living is one of the lowest, and the standard of living one of the highest in the U.K. Applications, in the form of a detailed CV with the names of two referees should be sent as soon as possible to Dr. Kieran Breen, Dept. of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, Scotland, U.K. from whom further details may be obtained (tel. 01382-633900 ext. 2522; e-mail: k.c.breen@dundee.ac.uk). Kieran Breen, Dept. of Pharmacology, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY,Scotland, U.K. k.c.breen@dundee.ac.uk From owner-bio-matrix@net.bio.net Mon Feb 06 22:00:00 1995 Path: biosci!adam.cc.sunysb.edu!news.sprintlink.net!pipex!lyra.csx.cam.ac.uk!sunsite.doc.ic.ac.uk!dundee.ac.uk!pathol4 From: (k.c.breen@dundee.ac.uk) Newsgroups: bionet.molbio.bio-matrix Subject: Research Studentship Followup-To: bionet.molbio.bio-matrix Date: 6 Feb 1995 17:45:52 GMT Organization: The University, Dundee, DD1 4HN, Scotland, UK. Lines: 34 Distribution: world Message-ID: <3h5n8g$n7p@dux.dundee.ac.uk> NNTP-Posting-Host: pathol4.medschool.dundee.ac.uk POSTGRADUATE STUDENTSHIP IN PHARMACOLOGY Applications are invited for a postgraduate studentship, funded by the Association for International Cancer Research, in a multi-disciplinary neuroglycobiology laboratory located in the Department of Pharmacology, University of Dundee. The 3 year studentship will examine the molecular biology of glycosyltransferase enzymes and the functional results of their altered expression in tumor cell lines. Applications are invited from candidates who expect to gain a first or upper-second class degree and although experience in the techniques of molecular biology would be advantageous, training will be provided where necessary. Ninewells Hospital Medical School is situated on the Tay estuary and is surrounded by beautiful countryside which provides excellent opportunities for a variety of outdoor activities. The cost of living is one of the lowest, and the standard of living one of the highest in the U.K. Applications, in the form of a detailed CV with the names of two referees should be sent as soon as possible to Dr. Kieran Breen, Dept. of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, Scotland, U.K. from whom further details may be obtained (tel. 01382-633900 ext. 2522; e-mail: k.c.breen@dundee.ac.uk). Kieran Breen, Dept. of Pharmacology, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY,Scotland, U.K. k.c.breen@dundee.ac.uk From owner-bio-matrix@net.bio.net Mon Feb 06 22:00:00 1995 Path: biosci!rutgers!uwm.edu!vixen.cso.uiuc.edu!howland.reston.ans.net!newsserver.jvnc.net!synapse.bms.com!news-admin From: mamber@synapse.bms.com (mamber) Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbi Subject: Re: controversies & ethics Date: 7 Feb 1995 15:24:32 GMT Organization: Bristol-Myers Squibb Lines: 14 Message-ID: <3h83bg$daf@synapse.bms.com> References: NNTP-Posting-Host: 140.176.141.202 Xref: biosci bionet.molbio.ageing:1247 bionet.molbio.bio-matrix:548 bionet.molbio.embldatabank:447 bionet.molbio.evolution:2419 bionet.molbio.gdb:293 In article , Phandaal says: > >I've been asked to give a lecture to upper-division college students on >the controversies and ethical considerations in producing transgenic >organisms, especially transgenic plants. >Peter Schuerman >plschuerman@ucdavis.edu How about lecturing on the benefits of creating transgenic tobacco plants that produce anticancer, anti-AIDS or other beneficial drugs instead of being used to make cigarettes and other smoking-related products? SWM mamber@synapse.bms.com From owner-bio-matrix@net.bio.net Tue Feb 07 22:00:00 1995 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.bio-matrix Subject: UNSUBSCRIBING, BIOSCI ARCHIVES, ADDRESS DATABASE & BIOSCI FAQ Date: 8 Feb 1995 02:00:25 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 338 Sender: daemon@net.bio.net Distribution: world Message-ID: <199502081000.CAA07931@net.bio.net> NNTP-Posting-Host: net.bio.net Four important items follow: How to cancel e-mail subscriptions to BIOSCI newsgroups, BIOSCI archive searching, the BIOSCI FAQ, and the BIOSCI User Address Directory form. If you have not yet listed yourself in our BIOSCI user directory, please take a few minutes to complete and return the form below. If your personal information has changed since you listed yourself, please send us a complete new updated form. We can not make manual revisions to existing entries. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net **** How to cancel a BIOSCI e-mail subscription **** If you want to cancel your e-mail subscription to this group, PLEASE DO NOT POST YOUR UNSUBSCRIBE REQUEST TO THE NEWSGROUP ADDRESS (NOR REPLY TO A MESSAGE POSTED TO THE NEWSGROUP)!!! This would send your request to all of the readers of the newsgroup, but it might still not be seen by the BIOSCI staff - thus you would annoy many people and possibly not accomplish your goal anyway. IF YOU ARE LOCATED IN THE AMERICAS OR PACIFIC RIM COUNTRIES, please send a message to biosci@net.bio.net Instructions on how to subscribe/unsubscribe will be returned automatically, so the contents of your message do not matter. IF YOU ARE LOCATED IN EUROPE, AFRICA OR CENTRAL ASIA, please send a message to MXT@dl.ac.uk containing the word help in the body of the message to retrieve e-mail server instructions. Any text placed on the Subject: line of your message will be ignored, so be sure to put the "help" command in the body of the message. If you need personal assistance, a BIOSCI staff member can be contacted at either of the following addresses. Please contact the address designated for your location. Support Address Location --------------- -------- biosci@daresbury.ac.uk Europe, Africa, and Central Asia biosci-help@net.bio.net Americas and the Pacific Rim **** SEARCHING BIOSCI ARCHIVES **** The easiest way to search the BIOSCI archives is to use gopher software and connect over the Internet to net.bio.net, the U.S. BIOSCI computer. We maintain three indexes which are searchable from the main gopher menu on net.bio.net: (1) an index of all BIOSCI postings; (2) an index of individual journal article references from the Table of Contents postings on the BIO-JOURNALS newsgroup; and (3) an index of BIOSCI users including regular mail and e-mail addresses, phone/FAX numbers, research interests, and newsgroup participation. E-mail users can search the BIOSCI archives by using our waismail e-mail server. For instructions send the message help to waismail@net.bio.net. Leave the Subject: line blank (anything entered on the Subject: line is ignored). WAIS software can also be used to search the archives as described in the BIOSCI FAQ (see below). Finally, the BIOSCI archive files are accessible by anonymous FTP to net.bio.net [134.172.2.69] in the directory pub/BIOSCI. **** BIOSCI FREQUENTLY ASKED QUESTIONS (FAQ) SHEET **** New users of BIOSCI/bionet may want to read the "Frequently Asked Questions" or "FAQ" sheet for BIOSCI. The FAQ provides details on how to participate in these forums and is available for anonymous FTP from net.bio.net [134.172.2.69] in pub/BIOSCI/doc/biosci.FAQ or for retrieval by gopher to net.bio.net, port 70. It may also be requested by sending the command info faq in the body of an e-mail message to the Internet address biosci-server@net.bio.net. Please do not enter the info faq command on the Subject: line of your message since the e-mail server ignores text on the Subject: line. The FAQ is also posted on the first of each month to the newsgroup BIONEWS/bionet.announce immediately following the posting of the BIOSCI information sheet. **** BIOSCI USER ADDRESS DIRECTORY **** Please take this opportunity to add your name and address information to the BIOSCI User Address Database if you have not already done so. Below is the address form that we would like each reader of the BIOSCI/bionet newsgroups to complete and return if you would like to be listed in our database. The database serves as a directory that enables biologists, who are currently using (or even just reading) the BIOSCI newsgroups, to look up e-mail addresses and other information about our users. The address database is reindexed nightly for WAIS, waismail, and gopher access. If you have access to gopher, connect to net.bio.net to search the database. If you have access to WAIS, please use our WAIS source biologists-addresses.src. If you are not on the Internet, please use our waismail server (send the word "help" to waismail@net.bio.net to get instructions; any text on the Subject: line of your message will be ignored, so put the help command in the body of the mail message.). Please carefully follow the instructions for completing the form below and return it to either of the following two addresses (whichever is more convenient for you). Thanks in advance for taking the time to complete and return the form. Addresses for returning forms Location Network ----------------------------- -------- ------- biovote@net.bio.net U.S.A. Internet/BITNET biovote@daresbury.ac.uk U.K. JANET MAKING SURE THAT YOUR INFORMATION IS CURRENT This notice will be mailed bimonthly to each newsgroup. You should check your database entry from time-to-time to see if your address information is still up-to-date. Using Gopher to complete the form --------------------------------- If you don't want to use a text editor, you can also use Dan Jacobson's gopher site to fill out the address database form as follows. Otherwise skip this section on gopher and proceed to the instructions for filling out the form below. > To add yourself to the database just point your > gopher client at merlot.gdb.org and select the following: > > --> 14. Searching For Biologists/ > > --> 9. E-mail Addresses of Biosci-Bionet Users/ > > --> 1. Add (or Correct) Your Address to the BIOSCI User Address > Data.. > > > And fill out the form. or Rob Harper's gopher site in Europe as follows: > Europeans can point their gopher client at gopher.csc.fi and add their > information to the database. All entries will be mailed directly to > Dave for incorporation in a wais source. > > The path to the questionare is as follows. > > > 6. Information in English/ > > 5. Scientific and other topics/ > > 1. Finnish EMBnet BioBox/ > > 9. FAQ Files/ > > 5. Bionauts Address Database (questionaire) > IMPORTANT INSTRUCTIONS - PLEASE READ CAREFULLY Please enter all responses after the : on each line, leaving one (1) blank space after the : (i.e., before the start of your text). Please do NOT extend your responses past the end of each line (80 characters). PLEASE DO NOT alter any of the field identifiers such as "first name: ". If you have nothing to enter after a field identifier, PLEASE LEAVE IT - do not delete it even if there is no data on the line in question. Several lines are provided at the end of the form for comments, but, please adhere to the line length restriction. On the date: line, please enter the date in the DD-MM-YY format, e.g., 15-05-93 for 15 May 1993. This line will tell others when the information was last updated. Please be sure to include the 0's for single digit days or months, e.g., 15-05-93, not 15-5-93. Note that the "e-mail network: " line below is for specifying, e.g., "Internet," "BITNET," "EARN," "JANET," or whatever other network that your computer may be on. If you are uncertain about any field, please feel free to leave it blank, but please DO NOT DELETE the field identifier from the form! In the first field below, "New information or Update ...", please enter "N" if this is the first time that you have registered in the directory or "U" if you are correcting a listing that you sent to us previously. The comment: lines may be used for anything that you like but PLEASE DO NOT DELETE THEM FROM THE FORM OR ALTER THEM. One suggested use is to list the names of the newsgroups in which you participate. Please use the MAILING LIST name (see below - the latest version of the list can be requested from biosci@net.bio.net) instead of the USENET name even if you don't participate by e-mail. WAIS might get confused by the periods in the USENET names. This allows one to retrieve via WAIS or waismail the list of participants in a particular group. For example: comment: ARABIDOPSIS PLANT-BIOLOGY BIONEWS On the comment: lines use these names below ---- NOT the USENET names below MAILING LIST NAME USENET Newsgroup Name ----------------- --------------------- ACEDB-SOFT bionet.software.acedb AGEING bionet.molbio.ageing AGROFORESTRY bionet.agroforestry ARABIDOPSIS bionet.genome.arabidopsis ASCB bionet.prof-society.ascb BIOCAN bionet.prof-society.cfbs BIOFORUM bionet.general BIO-INFORMATION-THEORY bionet.info-theory BIONAUTS bionet.users.addresses BIONEWS bionet.announce BIO-JOURNALS bionet.journals.contents BIO-MATRIX bionet.molbio.bio-matrix BIOPHYSICAL-SOCIETY bionet.prof-society.biophysics BIOPHYSICS bionet.biophysics BIO-SOFTWARE bionet.software BIOTHERMOKINETICS bionet.metabolic-reg BIO-WWW bionet.software.www CARDIOVASCULAR-RESEARCH bionet.biology.cardiovascular CELEGANS bionet.celegans CELL-BIOLOGY bionet.cellbiol CHLAMYDOMONAS bionet.chlamydomonas CHROMOSOMES bionet.genome.chromosomes COMPUTATIONAL-BIOLOGY bionet.biology.computational CSM bionet.prof-society.csm CYTONET bionet.cellbiol.cytonet DROSOPHILA bionet.drosophila EMBL-DATABANK bionet.molbio.embldatabank EMF-BIO bionet.emf-bio EMPLOYMENT bionet.jobs EMPLOYMENT-WANTED bionet.jobs.wanted FASEB bionet.prof-society.faseb GDB bionet.molbio.gdb GENBANK-BB bionet.molbio.genbank GENETIC-LINKAGE bionet.molbio.gene-linkage GRASSES-SCIENCE bionet.biology.grasses HIV-MOLECULAR-BIOLOGY bionet.molbio.hiv HUMAN-GENOME-PROGRAM bionet.molbio.genome-program IMMUNOLOGY bionet.immunology INFO-GCG bionet.software.gcg JOURNAL-NOTES bionet.journals.note METHODS-AND-REAGENTS bionet.molbio.methds-reagnts MICROBIOLOGY bionet.microbiology MOLECULAR-EVOLUTION bionet.molbio.evolution MOLECULAR-MODELLING bionet.molec-model MOLLUSC-MOLECULAR-NEWS bionet.molbio.molluscs MYCOLOGY bionet.mycology NEUROSCIENCE bionet.neuroscience N2-FIXATION bionet.biology.n2-fixation PARASITOLOGY bionet.parasitology PHOTOSYNTHESIS bionet.photosynthesis PLANT-BIOLOGY bionet.plants POPULATION-BIOLOGY bionet.population-bio PROTEIN-ANALYSIS bionet.molbio.proteins PROTEIN-CRYSTALLOGRAPHY bionet.xtallography PROTISTA bionet.protista RAPD bionet.molbio.rapd SCIENCE-RESOURCES bionet.sci-resources STADEN bionet.software.staden STRUCTURAL-NMR bionet.structural-nmr TROPICAL-BIOLOGY bionet.biology.tropical URODELES bionet.organisms.urodeles VIROLOGY bionet.virology WOMEN-IN-BIOLOGY bionet.women-in-bio YEAST bionet.molbio.yeast ZBRAFISH bionet.organisms.zebrafish Listing newsgroups on the comment: line is optional, of course. Thanks again for your cooperation! --------------- please cut here and return portion below --------------- New information or Update to old record (enter N or U): date (DD-MM-YY): first name: middle initial: family name: job title: e-mail address: e-mail network: phone number: FAX number: institution: address1: address2: address3: city: state/province: country: postal code: research interest: research interest: comment: comment: comment: comment: comment: From owner-bio-matrix@net.bio.net Wed Feb 08 22:00:00 1995 Newsgroups: bionet.molbio.bio-matrix Path: biosci!agate!howland.reston.ans.net!pipex!uknet!liv!lucs!rcp From: rcp@csc.liv.ac.uk (Ray Paton) Subject: Information Processing in Cells and Tissues Sender: news@csc.liv.ac.uk (News Eater) Message-ID: Date: Thu, 9 Feb 1995 12:47:48 GMT Lines: 113 Nntp-Posting-Host: rcp@seine.csc.liv.ac.uk Organization: Computer Science, Liverpool University SECOND CALL FOR PAPERS INTERNATIONAL WORKSHOP ON INFORMATION PROCESSING IN CELLS AND TISSUES Liverpool 6th - 8th September 1995 The purpose of this workshop is to bring together a multidisciplinary group of scientists working in the general area of modelling cells and tissues. A central theme will be the nature of biological information and the ways it is processed in cells and tissues. We hope that the workshop will draw together researchers from a range of disciplines including: Computer Science, Cell Biology, Mathematics, Physiology, Biophysics, Experimental Medicine, Biochemistry, Electronic Engineering and Biotechnology. The workshop is intended to provide a forum to report research, discuss emerging topics and gain new insights into information processing in biological and computational systems. Subjects areas are likely to include but not be restricted to: * Cellular information processing systems * Enzyme networks, Gene networks, Metabolic channeling * Second messenger systems * Signal Transduction and Cellular Pattern Recognition * Automata models * Parallel Distributed Processing models * Cellular Automata models * Single Neuron Computation * Biomolecular computing * Inter-cellular communication, Multi-cellularity * Information Processing in Developmental Systems * Information Processing in Immune networks * Endocrine-immune-nervous interactions * Information processing in neural tissue systems * Information processing in non-neural tissue systems * Communication and gap-junctions * Asynchronous processing, MIMD, SIMD and NIMD systems * Cell and tissues oscillators * Fractals and Chaos * Emergent phenomena and self-organisation Programme Committee Georg Brabant Endocrinology (Hanover) Michael Conrad Computer Science (Detroit) Roy Cuthbertson Cell Biology (Liverpool) Claus Emmeche Philosophy of Nature and Science Studies (Copenhagen) Mike Holcombe Computer Science (Sheffield) George Kampis Ethology and Philosophy of Science (Budapest) Hans-Paul Schwefel Computer Science (Dortmund) Idan Segev Neurobiology (Jerusalem) Gordon Shepherd Neurobiology (Yale) W Richard Stark Mathematics (Tampa) Rene Thomas Molecular Biology (Brussels) Chris Tofts Computer Science (Manchester) John Tucker Computer Science (Swansea) G Rickey Welch Biological Sciences (New Orleans) Gershom Zajicek Experimental Medicine and Cancer Research (Jerusalem) Organizing Committee Ray Paton, Roy Cuthbertson Mike Holcombe and 'Trina Houghton Sponsors GPT Unilever Submission Details All authors must submit 4 copies of the full technical paper by mail or delivery service to: Ray Paton Department of Computer Science The University of Liverpool Liverpool L69 3BX UK PLEASE DO NOT SUBMIT PAPERS BY FAX. The paper should be in English, double-spaced in 12 point using Times or similar font. The paper should be a maximum of 16 pages including the first page. The first page must contain: title of the paper, author's names including affiliations, complete mailing address, telephone and FAX numbers, email address, and a 250 word (maximum) abstract. Important Dates Submission deadline: Friday April 14th 1995 Acceptance Notification: Friday May 26th 1995 Deadline for final paper: Friday June 23rd 1995 PROCEEDINGS The papers accepted for the workshop will be bound into an unpublished collection for delegates. PUBLICATION OF THE PROCEEDINGS It is intended that a post workshop proceedings will be published by Springer-Verlag and will appear after the workshop. Enquiries Enquires should be addressed to Ray Paton at the above address or FAX +44 51 794 3715 or email tissues@csc.liv.ac.uk From owner-bio-matrix@net.bio.net Thu Feb 09 22:00:00 1995 Path: biosci!agate!dog.ee.lbl.gov!news.cs.utah.edu!news.cc.utah.edu!corona!patrick From: Patrick O'Neil Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.gene-linkage,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast Subject: Re: controversies & ethics Date: Thu, 9 Feb 1995 23:44:24 -0700 Organization: University Of Utah Computer Center Lines: 25 Message-ID: References: <3gk3au$pdp@rebecca.albany.edu> <3gm7u9$t5e@nntp1.u.washington.edu> NNTP-Posting-Host: corona.med.utah.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII In-Reply-To: <3gm7u9$t5e@nntp1.u.washington.edu> Xref: biosci bionet.molbio.ageing:1269 bionet.molbio.bio-matrix:554 bionet.molbio.embldatabank:451 bionet.molbio.evolution:2430 bionet.molbio.gdb:296 bionet.molbio.gene-linkage:544 bionet.molbio.genome-program:1179 bionet.molbio.hiv:888 bionet.molbio.rapd:973 bionet.molbio.yeast:2370 On 31 Jan 1995, Jared Roach wrote: > 2) The human race as a whole (or national governments, or > individuals) is slow to reach consensus on ethical issues (i.e. > religion, abortion, the creation of new species, etc.) Science > should slow its pace of discovery to allow Ethics to catch up. I could never go along with this point. What, tell us all that we should quit looking at this? Stop research concerning that? Take up a new trade, like house painting? I do and will continue to study and learn just as quickly as I am physically capable. I could never say, "well, that result sure does point to a VERY exciting, very interesting, line of research that would increase my understanding of x. Well, maybe I'll just cool my jets and let it go for a decade or so. Sure don't want to upset those who can't handle the fast pace of scientific understanding." In any case, it is a pointless thought since if this or that or those countries stopped research on x, then some other country or group would take it up because there would be a possible economic boon tied to it. If not us, then someone else. Humans have never and will never all agree to the same extent on ANYTHING. I would go to any location that would support what I am interested in researching, be it transgenics or gene therapy, etc. From owner-bio-matrix@net.bio.net Thu Feb 09 22:00:00 1995 Path: biosci!agate!dog.ee.lbl.gov!news.cs.utah.edu!news.cc.utah.edu!corona!patrick From: Patrick O'Neil Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.gene-linkage,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast Subject: Re: controversies & ethics Date: Thu, 9 Feb 1995 23:28:35 -0700 Organization: University Of Utah Computer Center Lines: 52 Message-ID: References: NNTP-Posting-Host: corona.med.utah.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII In-Reply-To: Xref: biosci bionet.molbio.ageing:1267 bionet.molbio.bio-matrix:553 bionet.molbio.embldatabank:450 bionet.molbio.evolution:2429 bionet.molbio.gdb:295 bionet.molbio.gene-linkage:543 bionet.molbio.genome-program:1178 bionet.molbio.hiv:887 bionet.molbio.rapd:972 bionet.molbio.yeast:2369 On Mon, 30 Jan 1995, Phandaal wrote: > I've been asked to give a lecture to upper-division college students on > the controversies and ethical considerations in producing transgenic > organisms, especially transgenic plants. It's been a while since I gave > this lecture, and so I was wondering if anybody had any good examples of > controversies or ethical considerations that I could incorporate into the > talk. I spent a year working in a plant molec bio lab that was being partially funded by a private company to produce a more fungal resistent sugarbeet. Technically, it would be a transgenic in that a gene, VERY closely related to an already present gene, from Arabidopsis was/is to be introduced into the sugarbeet and overexpressed, thus bolstering the sugarbeet's fungal resistence. I enjoyed the work very much and saw absolutely nothing wrong with it. It was making use of an already existent defensive gene that resides in many plants and simply increasing its output by using an easy to maniplate gene from a common lab plant. This sugarbeet will allow, hopefully, less use of chemical fungicides. You could argue that it will simply apply selective pressure for fungi to evolve resistence...but then, so does the use of fungicides or natural defenses. A more resistent fungi will, conversely, select for more fungal-resistent plants. This can be applied to your first point below too. > > Two I can think of off-hand are: > > 1) introducing insecticidal proteins (such as the Bacillus thuringiensis > protein) into plants may create resistant insect populations (under the > force of heavy selection pressure), which could then overrun the resistant > plants and make worthless the efforts by conventional growers who *use* Bt > protein as a topical pesticidal spray. The use of the spray itself puts selective pressure on insects to develop resistence. The point is moot. > > 2) altering fatty acid metabolism in oil-crops (like canola) so that they > produce oils found chiefly in palm and coconut could severely damage the > palm oil and coconut oil industries in Third World countries... thus > severely depressing the economies of these already struggling countries. If business was nice, then companies would never be put out of business. It may be tough but I could not support artificially supporting a weakly-based economy by ignoring a possible economic boon here. Any economy that ties itself to one commodity is *automatically* doomed to bite it pretty hard. Look at Louisiana and the effects of it having placed all its economic eggs in the oil business basket -- the state is only now beginning to recover from over a decade of depressed economy and hard times. Patrick From owner-bio-matrix@net.bio.net Thu Feb 09 22:00:00 1995 Path: biosci!HKUXA.HKU.HK!hrmbdkc From: hrmbdkc@HKUXA.HKU.HK (Cheah Kathryn Song Eng) Newsgroups: bionet.molbio.bio-matrix Subject: research funding as %GDP Date: 10 Feb 1995 03:04:55 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 19 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net I would appreciate it if anyone can send me information of the amount different countries (e.g. USA, UK, France, Germany, Japan, Taiwan, PRC, Korea, Singapore) spend on research as a % of their GDP. Or at least point me to a source of such information. Thanks in advance, Kathy Dr. Kathy Cheah Dept. Biochemistry Hong Kong University Sassoon Rd. Hong Kong Tel: (852)-28199170 (O) (852)-28199233 (Lab) Fax: (852)-28551254 E-mail: HRMBDKC@HKUXA.HKU.HK or HRMBDKC@HKUCC.BITNET From owner-bio-matrix@net.bio.net Thu Feb 09 22:00:00 1995 Path: biosci!agate!dog.ee.lbl.gov!news.cs.utah.edu!news.cc.utah.edu!corona!patrick From: Patrick O'Neil Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast,bionet.molbio.gene-linkage Subject: Re: controversies & ethics Date: Thu, 9 Feb 1995 23:52:53 -0700 Organization: University Of Utah Computer Center Lines: 20 Message-ID: References: <3gk3au$pdp@rebecca.albany.edu> <3gm7u9$t5e@nntp1.u.washington.edu> <3gml85$fb5@rebecca.albany.edu> NNTP-Posting-Host: corona.med.utah.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII In-Reply-To: Xref: biosci bionet.molbio.ageing:1270 bionet.molbio.bio-matrix:555 bionet.molbio.embldatabank:452 bionet.molbio.evolution:2431 bionet.molbio.gdb:297 bionet.molbio.genome-program:1180 bionet.molbio.hiv:889 bionet.molbio.rapd:974 bionet.molbio.yeast:2371 bionet.molbio.gene-linkage:545 On Wed, 1 Feb 1995, Howard M. Bomze wrote: > Steve Bonne has been saying that there are no new ethical > considerations for agricultural biotechnologies. However, he has been > missing one very important one, that is the possibility of an engineered > gene to be transfered to a different species. This already happens in nature by various means, one of which is viral. There is no absolute genetic sanctity in nature. As for transgenics, especially in plants, one tool for introducing foreign genes is agrobacteria. This microbe is fully capable of vectoring interspecific DNA without lab manipulation. The DNA so introduced in the lab does not carry any special DNA destabilizer, rather, it depends on the rather scattershot and low-yield natural method of homologous recombination or illegitimate recombination. Another method has absolutely no danger of transfering a new DNA transfer method to nature: the gene gun. DNA of interest bound to microscopic gold beads and shot into cells offers absolutely no threat of tranfering into an uncontrollable means of interspecific gene transfer in the wild. From owner-bio-matrix@net.bio.net Sun Feb 12 22:00:00 1995 Path: biosci!WRANGLER.LANL.GOV!rxl From: rxl@WRANGLER.LANL.GOV (Richard Light) Newsgroups: bionet.molbio.bio-matrix Subject: Society and the Future of Computing conference announcement Date: 13 Feb 1995 08:24:01 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 267 Sender: daemon@net.bio.net Distribution: world Message-ID: <9502131623.AA08210@wrangler.lanl.gov.cdiv-net> NNTP-Posting-Host: net.bio.net CONFERENCE ANNOUNCEMENT AND CALL FOR PARTICIPATION -------------------------------------------------- (Apologies for duplicates due to email list overlaps!) SOCIETY AND THE FUTURE OF COMPUTING '95 --------------------------------------- June 11-14, 1995 Tamarron Lodge Durango, Colorado Conference URL: --------------- http://www.lanl.gov/LANLNews/Conferences/.sfc95/sfcHome.html Conference Goals ---------------- As our national research community responds to new national needs, our society needs a vigorous and open discussion about the social goals of computer science research and applications. The end of the Cold War has changed the set of challenges facing the United States and its science and technology community. This conference will provide a forum in which to share, explore, and demonstrate the responsible use of advanced scientific computing and National Information Infrastructure program technologies for the benefit of diverse communities, and articulate novel research directions that advance computer science in ways that have high social benefits. Organizing Sponsors ------------------- This conference is an initiative of the U.S. Public Policy Committee of the Association for Computing Machinery (USACM), sponsored and organized by the Los Alamos National Laboratory in cooperation with the University of Maryland Human-Computer Interaction Laboratory and the ACM special interest groups SIGCAS, SIGCHI, and SIGCAPH, and (pending formal approval) IEEE US Activities. Additional Sponsors ------------------- Generous support for this conference has been provided by the following additional sponsors: Apple Computer, Inc. Cray Research, Inc. IBM POWER Parallel Division MCI Government Systems (Others expected.) Who Should Attend ----------------- This conference addresses a wide range of fields. Professionals from government, academia, and commerce will benefit from the innovative proposals for research and application. Computer scientists, commercial developers, government information specialists, research managers, directors of advanced technology, community planners, civic leaders, educators, vendors, and anyone interested in computing's social impact and the NII technologies can contribute to the discussions that are likely to shape some of the future directions of these themes. Relevant research areas include advanced networking, human-computer interaction, multimedia, wide area distributed computing, computer supported cooperative work, the design process, and integrating heterogeneous systems. Relevant applications include education, medicine, digital libraries, civic networking and teledemocracy, natural disaster prediction and response, transportation safety and efficiency, computing for people with disabilities, crime prevention, job training and skills improvement, workplace computing, sustainable environmental preservation, community networking and economic development, and intercommunity sharing of resources, among others. Conference Participation: ------------------------- In a retreat environment, invited speakers, panel organizers and panelists from academia, industry, and government will be joined by 40-50 poster presentations. THIS IS AN OPEN CALL FOR PARTICIPATION. We expect 30-50 posters to be displayed at the conference, and there will be two program sessions in which attendees will have the chance to discuss posters with the poster authors. Each poster entry will have a large conference poster board and a table on which to display the work. If your work is in any way related to the themes of this conference, you are encouraged to come share your ideas in the form of a poster presentation at the conference. The conference registration booklet details how you can submit your poster abstract describing your work and indicating the social impact of the work and its application to real-world problems. If you have questions regarding any aspect of poster participation in the conference, please contact the conference poster coordinator, Douglas Schuler, 206-865-3832, douglas@scn.org. The conference will be limited to 250 professional and 30 student attendees. EARLY REGISTRATION IS HIGHLY RECOMMENDED. We will offer scholarships for students wishing to attend this conference. Conference Structure and Speakers: ---------------------------------- The program begins Sunday evening and continues through approximately 4:00pm Wednesday afternoon. Monday and Tuesday afternoons include poster sessions in addition to the invited speaker sessions. Some sessions are panels while others present a series of noted speakers. The following is a preliminary list of participants, though the full list of speakers and panelists is still developing (in alphabetical order): Gary Chapman, University of Texas, Austin Peter J. Denning, George Mason University Gwendolyn Doebbert, California Department of Health Services Troy A. Eid, Executive Director, NIIT William J. Halverson, Pacific Bell Health Care Market Group Rob Kling, Unifersity of California, Irvine Dale Lehman, Fort Lewis College Richard Lowenberg, Telluride Institute Don Norman, Apple Computer Kent Norman, University of Maryland Roy Pea, Northwestern University Catherine Plaisant, University of Maryland Peggy Poggio, LLNL and Institute for Telemedicine Virginia E. Rezmierski, University of Michigan Leslie Sandberg, Executive Director, Institute for Telemedicine Ben Shneiderman, University of Maryland HCIL Barbara Simons, IBM; Chair, USACM Elliott Soloway, University of Michigan Connie D. Stout, University of Texas TENET Rolf Wigand, Syracuse University Stu Zweben, Ohio State University; President, ACM Conference Program ------------------ A copy of the preliminary program is included in the registration booklet. However, the following is the working list of session topics: <> Visions of the Future of Society and Computing <> Telemedicine, Medical Imaging, and Roadblocks on the Infobahn <> Home Life on the NII <> Social Needs and the Design Process <> Education Issues and Applications <> Digital Libraries: Information Management and the Citizen of Tomorrow <> Electronic Commerce and the Economy of Tomorrow <> Community Networks and Teledemocracy <> The Role of Government in NII and the Future of Computing <> New Directions for Society and the Future of Computing Student Scholarships -------------------- We are encouraging student attendence and participation in the conference by offering extensive scholarships for students whose major field of study is Computer Science, or Social Sciences with computer-related emphasis. The conference registration booklet details how you can submit your application for a student scholarship. Students who participate in the program will also be asked to help with conference logistics. Conference Location ------------------- This conference is being held at the Tamarron Lodge, 18 miles north of Durango, in southwestern Colorado. This is a full-service hotel that specializes in conferences and workshops. The beautiful mountain surroundings and the secluded location provide for a unique and productive environment for conference discussions. Hotel and airline reservation information is included in the conference registration booklet. The Durango airport supports regular flights to Denver, Phoenix, and Albuquerque. Conference Registration Information ----------------------------------- To receive a registration booklet including information about student scholarships, poster entries, the conference program, conference fees, the Durango area, travel arrangements, and the Tamarron Lodge, please send your name, US postal address, email address, and phone number to the conference registrar at one of the following addresses: Email address: sfc95@lanl.gov We would prefer that you use email to request registration information. However, if you have no access to email, please send your request to: SFC '95 Conference Registrar Protocol Office, Attn: Jan Hull Mail Stop P366 Los Alamos National Laboratory Los Alamos, NM 87545 USA Conference Co-Chairs -------------------- Rick Light, LANL, rxl@lanl.gov Ben Shneiderman, University of Maryland, ben@cs.umd.edu Executive Advisor for the Program --------------------------------- Andy White, LANL, abw@lanl.gov Program Committee ----------------- Phil Agre, Program Chair, UC San Diego, pagre@weber.ucsd.edu Dan Kerlinsky, UNM, dkerlins@medusa.unm.edu Rob Kling, UC Irvine, kling@ics.uci.edu Barbara Simons, IBM, simons@vnet.ibm.com Marc Rottenberg, CPSR, rotenberg@washofc.cpsr.org Rick Weingarten, CRA, rick@cra.org Conference Coordinator ---------------------- Jan Hull, LANL, jhull@lanl.gov Conference Multimedia Specialist -------------------------------- Jim Cruz, LANL, cruzn@lanl.gov From owner-bio-matrix@net.bio.net Wed Feb 15 22:00:00 1995 Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.gene-linkage,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast Path: biosci!daresbury!trane.uninett.no!ugle.unit.no!news.uit.no!pclab12.hibo.no!FG1 From: FG1@stud.hibo.no Subject: Re: controversies & ethics Sender: news@news.uit.no (News admin.) Message-ID: Date: Thu, 16 Feb 1995 10:34:11 GMT Lines: 58 References: Organization: Bodoe College X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] Xref: biosci bionet.molbio.ageing:1331 bionet.molbio.bio-matrix:557 bionet.molbio.embldatabank:457 bionet.molbio.evolution:2449 bionet.molbio.gdb:301 bionet.molbio.gene-linkage:562 bionet.molbio.genome-program:1199 bionet.molbio.hiv:914 bionet.molbio.rapd:987 bionet.molbio.yeast:2405 In article Patrick O'Neil writes: >From: Patrick O'Neil >Subject: Re: controversies & ethics >Date: Thu, 9 Feb 1995 23:28:35 -0700 >On Mon, 30 Jan 1995, Phandaal wrote: >> I've been asked to give a lecture to upper-division college students on >> the controversies and ethical considerations in producing transgenic >> organisms, especially transgenic plants. It's been a while since I gave >> this lecture, and so I was wondering if anybody had any good examples of >> controversies or ethical considerations that I could incorporate into the >> talk. > I spent a year working in a plant molec bio lab that was being partially >funded by a private company to produce a more fungal resistent >sugarbeet. Technically, it would be a transgenic in that a gene, VERY >closely related to an already present gene, from Arabidopsis was/is to be >introduced into the sugarbeet and overexpressed, thus bolstering the >sugarbeet's fungal resistence. I enjoyed the work very much and saw >absolutely nothing wrong with it. It was making use of an already >existent defensive gene that resides in many plants and simply increasing >its output by using an easy to maniplate gene from a common lab plant. >This sugarbeet will allow, hopefully, less use of chemical fungicides. > You could argue that it will simply apply selective pressure for fungi >to evolve resistence...but then, so does the use of fungicides or natural >defenses. A more resistent fungi will, conversely, select for more >fungal-resistent plants. This can be applied to your first point below too. >> >> Two I can think of off-hand are: >> >> 1) introducing insecticidal proteins (such as the Bacillus thuringiensis >> protein) into plants may create resistant insect populations (under the >> force of heavy selection pressure), which could then overrun the resistant >> plants and make worthless the efforts by conventional growers who *use* Bt >> protein as a topical pesticidal spray. >The use of the spray itself puts selective pressure on insects to develop >resistence. The point is moot. >> >> 2) altering fatty acid metabolism in oil-crops (like canola) so that they >> produce oils found chiefly in palm and coconut could severely damage the >> palm oil and coconut oil industries in Third World countries... thus >> severely depressing the economies of these already struggling countries. >If business was nice, then companies would never be put out of business. >It may be tough but I could not support artificially supporting a >weakly-based economy by ignoring a possible economic boon here. Any >economy that ties itself to one commodity is *automatically* doomed to bite >it pretty hard. Look at Louisiana and the effects of it having placed >all its economic eggs in the oil business basket -- the state is only now >beginning to recover from over a decade of depressed economy and hard times. >Patrick From owner-bio-matrix@net.bio.net Tue Feb 21 22:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!news.sprintlink.net!uunet!news.inhouse.compuserve.com!news.production.compuserve.com!news From: Tim Johnson <74557.3134@CompuServe.COM> Newsgroups: bionet.biology.tropical,bionet.molbio.bio-matrix,bionet.mycology,bionet.plants,misc.health.alternative Subject: Database of Plants & Their Uses Date: 22 Feb 1995 22:01:53 GMT Organization: Overmind Lines: 24 Message-ID: <3igc8h$7fa$1@mhade.production.compuserve.com> Xref: biosci bionet.biology.tropical:820 bionet.molbio.bio-matrix:558 bionet.mycology:1602 bionet.plants:5696 misc.health.alternative:23012 I just finished the first version of Herbage, a shareware program for DOS. This program allows searches of a very large database of plants from all around the world. You can search in 10 categories, including alkaloid and nutrition content, native range and habitat, traditional uses for specific illnesses, and U.S. mail-order sources. This program is the result of two years of research using object-oriented and relational data models. As far I as know, this is the first program to make use of this technology for the collection of plant information. It is available: 1. Compuserve \ New Age Forum \ IBM PC Files 2. Compuserve \ Gardening \ New Uploads 3. Compuserve \ Holistic Health \ Herbs & Plants 4. America Online \ Learning & Reference \ Educational Software \ PC/MS DOS Educational Software \ New Education Files Within a week or so, it will be available on the FTP site: oak.oakland.edu \ simtel \ msdos \ food - Tim Johnson From owner-bio-matrix@net.bio.net Thu Feb 23 22:00:00 1995 Path: biosci!adam.cc.sunysb.edu!news.nysernet.net!news.sprintlink.net!howland.reston.ans.net!EU.net!sun4nl!news.euro.net!p88.euronet.nl!mbleeker From: mbleeker@euronet.nl (Marco_Bleeker) Newsgroups: bionet.biology.tropical,bionet.molbio.bio-matrix,bionet.mycology,bionet.plants,misc.health.alternative Subject: Re: Database of Plants & Their Uses Date: Fri, 24 Feb 1995 02:33:10 Organization: Euronet Internet Lines: 10 Message-ID: References: <3igc8h$7fa$1@mhade.production.compuserve.com> NNTP-Posting-Host: p88.euronet.nl X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] Xref: biosci bionet.biology.tropical:827 bionet.molbio.bio-matrix:559 bionet.mycology:1609 bionet.plants:5730 misc.health.alternative:23109 >I just finished the first version of Herbage, a shareware program >for DOS. This program allows searches of a very large database of >plants from all around the world. Hi Tim Which very large databases - how do you connect up ? Is Herbage an empty RDBMS, or are there data in it already ? Marco From owner-bio-matrix@net.bio.net Sun Feb 26 22:00:00 1995 Newsgroups: bionet.biology.tropical,bionet.molbio.bio-matrix,bionet.mycology,bionet.plants,misc.health.alternative Path: biosci!agate!newsxfer.itd.umich.edu!caen!msunews!harbinger.cc.monash.edu.au!news.cs.su.oz.au!metro!news From: asalter@geko.com.au (Adrian Salter) Subject: Re: Database of Plants & Their Uses Message-ID: Sender: news@ucc.su.OZ.AU Nntp-Posting-Host: dialup11.geko.com.au Organization: Grow-How References: <3igc8h$7fa$1@mhade.production.compuserve.com> Date: Mon, 27 Feb 1995 10:25:10 GMT Lines: 17 Xref: biosci bionet.biology.tropical:835 bionet.molbio.bio-matrix:562 bionet.mycology:1625 bionet.plants:5784 misc.health.alternative:23392 In article , mbleeker@euronet.nl (Marco_Bleeker) wrote: >>I just finished the first version of Herbage, a shareware program >>for DOS. This program allows searches of a very large database of >>plants from all around the world. > > Which very large databases - how do you connect up ? Is Herbage an >empty RDBMS, or are there data in it already ? I'm interested too. Could you please send some details by email? Thanks. Adrian From owner-bio-matrix@net.bio.net Sun Feb 26 22:00:00 1995 Path: biosci!agate!library.ucla.edu!csulb.edu!nic-nac.CSU.net!charnel.ecst.csuchico.edu!news.xmission.com!news.cc.utah.edu!corona!patrick From: Patrick O'Neil Newsgroups: bionet.molbio.ageing,bionet.molbio.bio-matrix,bionet.molbio.embldatabank,bionet.molbio.evolution,bionet.molbio.gdb,bionet.molbio.gene-linkage,bionet.molbio.genome-program,bionet.molbio.hiv,bionet.molbio.rapd,bionet.molbio.yeast Subject: Re: controversies & ethics Date: Sun, 26 Feb 1995 20:33:58 -0700 Organization: University Of Utah Computer Center Lines: 55 Message-ID: References: <3gk3au$pdp@rebecca.albany.edu> <3gm7u9$t5e@nntp1.u.washington.edu> NNTP-Posting-Host: corona.med.utah.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII In-Reply-To: <3gm7u9$t5e@nntp1.u.washington.edu> Xref: biosci bionet.molbio.ageing:1462 bionet.molbio.bio-matrix:561 bionet.molbio.embldatabank:459 bionet.molbio.evolution:2494 bionet.molbio.gdb:304 bionet.molbio.gene-linkage:583 bionet.molbio.genome-program:1231 bionet.molbio.hiv:937 bionet.molbio.rapd:1011 bionet.molbio.yeast:2477 On 31 Jan 1995, Jared Roach wrote: > Now one might argue that the speed of recombinant research > has two dangers: > 1) The rest of the ecosystem is not changing as fast to > modify itself so as to maintain some kind of ecological "balance." > Furthermore, scientists may be slower to understand ecological impact > than they are in developing new organisms. This is not just restricted to transgenics. Chemical companies and farmers don't want nature to catch up to pesticides too quickly (if at all) so would it be bad if DOW, for instance, came up with a pesticide that insects or fungi were extremely slow to catch up to? (Leaving the debate over the use of such chemicals aside for the moment) The whole basis of farming is one of a state of unbalance. A field made up of only one species of plant is not, itself, natural and is unbalanced. Plants being protected by human interventions from predators is unbalanced. If it was all let alone then balance would come but at the expense of food for the populous. Where and what is a good state of unbalance, then? Even organic farming requires human-induced unbalancing through the artificial increased mass of fertilizing manure, introduction of unnatural numbers of beneficial insects, etc. > 2) The human race as a whole (or national governments, or > individuals) is slow to reach consensus on ethical issues (i.e. > religion, abortion, the creation of new species, etc.) Science > should slow its pace of discovery to allow Ethics to catch up. > Some of these areas will NEVER be an area of consensus. The new species that I have seen/read about are incredibly specialized and always based on natural examples (hydrocarbon consuming bacteria). A beefalo isn't itself so odd, for instance, except in name. They are a melding of two very closely related species and like cattle, are not set up to take over the world...just dinner tables. I am no fan of the cattle industry but is such specialized living food really any worse than any domesticated food animal, bred for sloth, even temper, tender haunches, etc? In any case, the idea, "Science should slow down discovery" is disturbing. I again ask, what do you do, tell a scientist that he or she is doing too well and finding out too much? Knowledge is deadly and bad? More disturbing to me than any talk of _unthinking_ tampering with lifespan to any significant degree is the idea that one can know too much. One can learn too much. Religions tend to take that position when their particular belief system is threatened by some bit of knowledge. So, just cover your eyes and ears and pretend that what is so is NOT so? Knowledge is NEVER the problem, it is how you use it. That said, transgenics is not, in and of itself, bad unless it is done foolishly and for the wrong reasons. I presently work with transgenic mice in a cancer research lab. They are indespensible to the research. Patrick From owner-bio-matrix@net.bio.net Sun Feb 26 22:00:00 1995 Path: biosci!agate!edster.berkeley.edu!user From: eskin@nak.berkeley.edu (Edster) Newsgroups: bionet.biology.tropical,bionet.molbio.bio-matrix,bionet.mycology,bionet.plants,misc.health.alternative Subject: Re: Database of Plants & Their Uses Date: Sun, 26 Feb 1995 18:33:43 -0700 Organization: Here Lines: 5 Message-ID: References: <3igc8h$7fa$1@mhade.production.compuserve.com> NNTP-Posting-Host: edster.berkeley.edu Xref: biosci bionet.biology.tropical:834 bionet.molbio.bio-matrix:560 bionet.mycology:1621 bionet.plants:5780 misc.health.alternative:23353 Tim, I am interested in your database but went to oak.oakland.edu and couldn't find it. Is the name of the program Herbage? Is it there yet. Thanks, Ed From owner-bio-matrix@net.bio.net Sun Feb 26 22:00:00 1995 Path: biosci!rutgers!gatech!howland.reston.ans.net!vixen.cso.uiuc.edu!uchinews!uwvax!sun6.cs.wisc.edu!seavey From: seavey@sun6.cs.wisc.edu (Beverly Seavey) Newsgroups: bionet.molbio.bio-matrix Subject: Whatever happened to LIMB database? Date: 27 Feb 1995 22:51:57 GMT Organization: U of Wisconsin CS Dept Lines: 2 Message-ID: <3itl2d$jve@spool.cs.wisc.edu> NNTP-Posting-Host: sun6.cs.wisc.edu Does anyone have a pointer to the LIMB database, or to a database devoted to tRNA sequences? From owner-bio-matrix@net.bio.net Mon Feb 27 22:00:00 1995 Newsgroups: bionet.molbio.bio-matrix Path: biosci!daresbury!hgmp.mrc.ac.uk!ebi.ac.uk!harper From: harper@ebi.ac.uk (Rob Harper) Subject: Re: Whatever happened to LIMB database? Sender: news@ebi.ac.uk (Mr news) Message-ID: Date: Tue, 28 Feb 1995 16:41:52 GMT Lines: 44 Reply-To: harper@ebi.ac.uk References: <3itl2d$jve@spool.cs.wisc.edu> Organization: European Bioinformatics Institute (EMBL) - UK X-Newsreader: mxrn 6.18-16 In article <3itl2d$jve@spool.cs.wisc.edu>, seavey@sun6.cs.wisc.edu (Beverly Seavey) writes: >Does anyone have a pointer to the LIMB database, >or to a database devoted to tRNA sequences? You can gain acess to LIMB at the EBI WWW server at the URL http://www.ebi.ac.uk/srs/srsc This will allow you to query LIMB as well as the following datbases Name Release Entries Indexing Date Library Group SWISSPROT 40292 24-Nov-1994 Sequence SWISSNEW 7746 18-Feb-1995 Sequence PIR 71995 18-Feb-1995 Sequence EMBL 234501 11-Dec-1994 Sequence EMNEW 77415 28-Feb-1995 Sequence NRL3D 4153 18-Feb-1995 Sequence NRSUB 248 18-Feb-1995 Sequence PDB 3331 17-Feb-1995 ProteinStruct HSSP 2074 17-Feb-1995 ProteinStruct DSSP 2178 28-Feb-1995 ProteinStruct ALI 84 24-Nov-1994 ProteinStruct FSSP 284 17-Feb-1995 ProteinStruct PROSITE 1029 18-Feb-1995 SeqRelated PROSITEDOC 786 18-Feb-1995 SeqRelated BLOCKS 770 18-Feb-1995 SeqRelated EPD 1251 18-Feb-1995 SeqRelated ECDC 3571 18-Feb-1995 SeqRelated ENZYME 3546 18-Feb-1995 SeqRelated REBASE 2454 18-Feb-1995 SeqRelated PRODOM 23105 18-Feb-1995 SeqRelated FLYGENE 6614 18-Feb-1995 SeqRelated SWISSDOM 28224 18-Feb-1995 SeqRelated PIRALN 1183 18-Feb-1995 SeqRelated SEQANALREF 2579 18-Feb-1995 Literature MEDLINE 168773 06-Dec-1994 Literature LIMB 120 18-Feb-1995 Others TFSITE 4042 18-Feb-1995 TransFac TFFACTOR 1412 18-Feb-1995 TransFac RGDS -=ROB=-