From owner-biophysics@net.bio.net Mon Jul 01 23:00:00 1996 Path: biosci!agate!howland.reston.ans.net!world1.bawave.com!news2.cais.net!news.cais.net!nntp.uio.no!nntp-oslo.UNINETT.no!nntp-trd.UNINETT.no!daresbury!not-for-mail From: Frances Separovic Newsgroups: bionet.biophysics Subject: NMR Research Fellow Date: 2 Jul 1996 04:34:23 +0100 Lines: 43 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <4ra5bv$l8q@mserv1.dl.ac.uk> Original-To: Biophys , Biophysics Research Fellow In NMR Spectroscopy A research fellowship in NMR spectroscopy is available with the School of Chemistry, University of Melbourne, Australia. The School has a wide range of research interests in structural and solution NMR studies in organic, inorganic and biological chemistry. You, with the help of a Professional Officer, will be responsible for the daily function of the NMR Centre, technique development and training. You will be encouraged to undertake collaborative research. The NMR centre at the School of Chemistry is equipped with 4 Varian NMR spectrometers: an Inova 400, Unity Plus 400, Unity 300 and an Inova 300 for solid-state work plus 2 Sparc workstations for data processing and 20% access to a Bruker DRX 500 NMR spectrometer. Planning to gain access to higher field instruments has a high priority. You will have a relevant post graduate qualification and some experience in most solution state NMR techniques with emphasis on the structural studies of organic molecules and/or biomolecules. Experience with molecular dynamics calculations and computational methods in solution structural refinement of biological macromolecules would be particularly desirable. This appointment will be for three years (Limited Tenure). Salary: $30130 - $40889 pa (Research Fellow Grade 1). For further information, position description and the School Research Booklet contact: Associate Professor Frances Separovic (61-3) 9344 6464; fax (61-3) 9347 5180 e-mail: Frances_Separovic@muwayf.unimelb.edu.au Applications close: 27 July 1996 Reference number: Y0003776 Applications (including the names and facsimile numbers of three referees) should quote the reference number and be sent in duplicate to the Director, Human Resources, The University of Melbourne, Parkville, Victoria, 3052 Australia; fax (61-3) 9344 4694. Applications will not be acknowledged but you will be advised of the outcome. The University of Melbourne is an equal opportunity employer and has a smoke-free workplace policy. THE AUSTRALIAN UNI APPOINTS SAT 6 JULY 1996 LINE AD WITH LOGO From owner-biophysics@net.bio.net Sun Jul 07 23:00:00 1996 Newsgroups: bionet.biophysics Path: biosci!bcm.tmc.edu!pendragon!news.msfc.nasa.gov!newsfeed.internetmci.com!in1.uu.net!sangam!iitb!powai!powai.cc.iitb.ernet.in!bvi From: bvi@powai.cc.iitb.ernet.in (bhakti vedanta institute) Subject: M.S. Program in Consciousness Studies Sender: news@powai.cc.iitb.ernet.in (news system user) Message-ID: Date: Mon, 8 Jul 1996 08:07:32 GMT Organization: Computer Centre, Indian Institute of Technology, Bombay X-Newsreader: TIN [version 1.2 PL2] Lines: 53 The Bhaktivedanta Institute-Center for Studies in Consciousness and Science offers Master of Science (MS) degree program in Consciousness Studies "The mosaic of scientific knowledge has arrived at a historical juncture at which the question "What Is Consciousness?" is being asked on more grounds that philosophy and religion or metaphors of information technology. This juncture is characterized by the appearance of numerous journals, conferences, summer schools, and university courses on Consciousness Studies" Salient features of this program: * The program is in collaboration with the Birla Institute of Technology and Science (BITS), Pilani, one of India's top technical schools. * The Bhaktivedanta Institute is a pioneer in this field with the credential of having successfully conducted an international conference, "Consciousness Within Science", in San Francisco in 1990. At present a monthly colloquium on Consciousness Studies is being held in San Francisco. * This program is a multidisciplinary program encompassing a wide variety of fields including physics, chemistry, mathematics, computer science, philosophy, religion, and the biological sciences. * On completion of the program, you can proceed for a PhD program at any University around the world. Duration : Three semesters Eligibility : Bachelor's degree in any of the sciences/engineering and/or a Master's degree in any of the above or a related field such as philosophy, psychology, etc. Course commences: September 1996 For further details, please contact: Mukunda Madhava Dasa Assistant Dean (Academic Affairs) Bhaktivedanta Institute Juhu Road, Juhu Bombay 400 049 India Phone : (22) 620-6332 Fax : (22) 620-0596 E-mail : mukunda.madhava.bsds@com.bbt.se or bvi@cc.iitb.ernet.in From owner-biophysics@net.bio.net Tue Jul 09 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!swrinde!news-res.gsl.net!news.gsl.net!hunter.premier.net!uunet!in1.uu.net!newsfeed.pitt.edu!dsinc!netnews.upenn.edu!mail2.sas.upenn.edu!maggarwa From: maggarwa@mail2.sas.upenn.edu (Manoj Aggarwal) Newsgroups: bionet.biophysics Subject: Sticking cells/polyballs to glass Date: 10 Jul 1996 16:16:10 GMT Organization: University of Pennsylvania Lines: 7 Message-ID: <4s0l0a$ua8@netnews.upenn.edu> NNTP-Posting-Host: mail2.sas.upenn.edu X-Newsreader: TIN [version 1.2 PL2-upenn1.3] DOes anyone have a protocal for sticking cells/polystyrene balls to glass? Also, information on the mechanism which does this would be appreciated as well. Thanks Manoj From owner-biophysics@net.bio.net Tue Jul 09 23:00:00 1996 Path: biosci!bcm.tmc.edu!pendragon!news.msfc.nasa.gov!newsfeed.internetmci.com!news.dacom.co.kr!nntp.coast.net!lll-winken.llnl.gov!usenet From: Chris Barry Newsgroups: bionet.biophysics Subject: Re: Sticking cells/polyballs to glass Date: Wed, 10 Jul 1996 10:07:56 -0700 Organization: Lawrence Livermore National Lab Lines: 20 Message-ID: <31E3E36C.A9D0B5C@llnl.gov> References: <4s0l0a$ua8@netnews.upenn.edu> NNTP-Posting-Host: mackiller.llnl.gov Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.01 (X11; I; Linux 1.1.72 i486) To: Manoj Aggarwal Well it depends on what kind of spheres you are talking about. I have some experience with carboxylated polystyrene spheres and glass. My big problem was trying to get them to not stick. In my case the sticking was electrostatic. I think the charge of glass is negative and so is the carboxylated microsphere (in solution at the pH above the pKa of silicon oxide and the carboxyl groups). One would then expect the two like charges to repell each other. I now believe thet the presence of divalent ions (ie Mg++) can bridge the two like charges together. I would also be interested is someone had an alternative explanation or similar observation. Chris Manoj Aggarwal wrote: > > DOes anyone have a protocal for sticking cells/polystyrene balls > to glass? Also, information on the mechanism which does this > would be appreciated as well. > > Thanks Manoj From owner-biophysics@net.bio.net Wed Jul 10 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news-res.gsl.net!news.gsl.net!nntp.coast.net!howland.reston.ans.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!news.interport.net!usenet From: jmarti@interport.net (JAM) Newsgroups: bionet.biophysics Subject: Nigericin info needed Date: Thu, 11 Jul 1996 14:48:35 GMT Organization: Interport Communications Corp. Lines: 14 Message-ID: <4s3461$1t9@park.interport.net> NNTP-Posting-Host: bs-lab.port.net X-Newsreader: Forte Free Agent v0.55 I have read conflicting information regarding the effects of nigericin on live cells in normal physiologic media: (1) Dissipates _membrane potential_ only, while not disrupting active transport or other physiologic activities OR (2) Dissipates _pH gradient_ in addition to potential and affects all cellular processes. Again, this is under normal conditions, not as a tool to make a standard curve for intracellular pH measurements. My ultimate goal is to dissipate or equilibrate the pH gradient OR the membrane potential across the plasma membrane and then measure uptake of a compound. Any help would be appreciated, James Martiney, Ph.D. sherry.lab@picower.edu From owner-biophysics@net.bio.net Wed Jul 10 23:00:00 1996 Path: biosci!rutgers!uwm.edu!cs.utexas.edu!swrinde!newsfeed.internetmci.com!news.thecia.net!usenet From: Michael Sean Davis Newsgroups: bionet.biophysics Subject: Seeking Basic Info. About the Visual System Date: Thu, 11 Jul 1996 10:30:10 -0400 Organization: Complete Internet Access Lines: 22 Message-ID: <31E50FF2.35F0@thecia.net> NNTP-Posting-Host: ppp-26.cambridge.thecia.net Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.01KIT (Win95; U) I am graduate student in the process of writing my dissertation in need of a quick answer (if one exists) to a question about the visual system. In perusing intro. level textbooks, I find seemingly agreed upon theories explaining color vision, but I don't find detailed theories explaining the perception of brightness. One text seems to vaguely suggest that brightness might be caused by the summed total activity of the photoreceptors in the retina. Is this theory correct? If not, what, if any, is the agreed upon physiological theory for explaining the perception of brightness? Any help on this issue would be greatly appreciated. Thanks. -Michael Sean Davis davis@thecia.net From owner-biophysics@net.bio.net Wed Jul 10 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!swrinde!newsfeed.internetmci.com!hunter.premier.net!news2.cais.net!news.cais.net!nntp.primenet.com!uunet!in1.uu.net!csnews!coopnews.coop.net!boulder.earthnet.net!usenet From: "Phillip E. Schwartz" Newsgroups: bionet.biophysics Subject: New FDA Regs/Antibodies Date: Thu, 11 Jul 1996 12:37:00 -0700 Organization: Affinity BioReagents, Inc. Lines: 42 Message-ID: <31E557DC.2287@bioreagents.com> NNTP-Posting-Host: slip12.earthnet.net Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 8bit X-Mailer: Mozilla 2.0 (Win16; I) Please help! Will the individual at your organization who is in charge of regulatory affairs or who is concerned about the negative effects new FDA regulations may have on basic scientific and medical research in addition to health care in general please contact me regarding this matter. I am trying to get as many people to comment on and become involved in a grass-roots effort to keep the FDA from including all antibody research reagents as ‘in vitro diagnostic devices’. Granted, some are but most are not. Please review the information at: http:/www.earthnet.net/~affinity/fda/ It would be optimal if this website could be hotlinked to yours to gain the maximum amount of exposure prior to August 30, 1996 public comment deadline. I would appreciate any comments, questions, referred contacts, etc. that may be useful in changing the language of this pending FDA regulation. FDA Regulation: The Immunohistochemistry Reagents and Kits Regulation: 21/CFR 864 Docket Number: 94P-0342 Sincerely, Phillip E. Schwartz Antibody Partnership Project Manager Affinity BioReagents, Inc. 14818 W. 6th Ave., Suite 13A Golden, CO 80401 TEL: 800-527-4535 FAX: 303-278-2424 email: schwartz@bioreagents.com website: http://www.bioreagents.com/affinity From owner-biophysics@net.bio.net Wed Jul 10 23:00:00 1996 Path: biosci!FIONA.UMSMED.EDU!davidson From: davidson@FIONA.UMSMED.EDU ("Victor L. Davidson") Newsgroups: bionet.biophysics Subject: Re: Nigericin info needed Date: 11 Jul 1996 10:42:43 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 27 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <4s3461$1t9@park.interport.net> NNTP-Posting-Host: net.bio.net On Thu, 11 Jul 1996, JAM wrote: > I have read conflicting information regarding the effects of nigericin > on live cells in normal physiologic media: (1) Dissipates _membrane > potential_ only, while not disrupting active transport or other > physiologic activities OR (2) Dissipates _pH gradient_ in addition to > potential and affects all cellular processes. Again, this is under > normal conditions, not as a tool to make a standard curve for > intracellular pH measurements. My ultimate goal is to dissipate or > equilibrate the pH gradient OR the membrane potential across the > plasma membrane and then measure uptake of a compound. Any help would > be appreciated, > > James Martiney, Ph.D. > sherry.lab@picower.edu > > > Although these are a bit old, for good general reviews check Methods in Enzymology Vol. 55 (1979). A review on ionophores (such as nigericin) pp. 435-454 A review on uncouplers pp. 462-472 Victor From owner-biophysics@net.bio.net Thu Jul 11 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!news.tamu.edu!tam2000.tamu.edu!rms1754 From: Rene Mauricio Salazar Newsgroups: bionet.biophysics Subject: acupuncture research Date: Fri, 12 Jul 1996 11:57:47 -0500 Organization: Texas A&M University, College Station, TX Lines: 9 Message-ID: NNTP-Posting-Host: tam2000.tamu.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Hello, Does anyone know of any researchers currently doing work in acupuncture or human bioelectric fields in Texas or anywhere in the continental U.S.? Thanks in advance. Rene' M. Salazar From owner-biophysics@net.bio.net Thu Jul 11 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news-res.gsl.net!news.gsl.net!swrinde!elroy.jpl.nasa.gov!lll-winken.llnl.gov!nntp.coast.net!harbinger.cc.monash.edu.au!news.mel.connect.com.au!esmeralda.access.net.au!usenet From: dhelix@share.access.net.au (Cameron Jones) Newsgroups: bionet.biophysics Subject: Online Fractal Analysis article & Software Date: Fri, 12 Jul 1996 06:07:54 GMT Organization: A poorly-installed InterNetNews site Lines: 36 Message-ID: <4s4tmr$mec@esmeralda.access.net.au> NNTP-Posting-Host: ppp05.access.net.au X-Newsreader: Forte Free Agent 1.0.82 You may be interested in the following web paper: 2-D Wavelet Packet Analysis of Structural Self-Organisation and Morphogenic Regulation in Filamentous Fungal Colonies URL: http://www.swin.edu.au/chem/bio/cs96/camjones.htm Additional software in S-Plus is available to calculate the global Fractal Dimension using the above methods. A full paper and software ready for downloading is available from: URL: http://www.swin.edu.au/chem/bio/s+code/wpafrac1.htm I would be interested in any readers comments, or potential interest in collaboration. I can be contacted at the following email addresses: work: CJONES@swin.edu.au home: dhelix@access.net.au Sincerely, Cameron L. Jones (Research Fellow) Centre for Applied Colloid and BioColloid Science Swinburne University of Technology School of Chemical Sciences P.O. Box 218 Hawthorn Victoria 3122 AUSTRALIA Tel: +613 9214 8935 Fax: +613 9819 0834 Email: CJONES@swin.edu.au From owner-biophysics@net.bio.net Mon Jul 15 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!swrinde!howland.reston.ans.net!EU.net!news.eunet.fi!news.spb.su!satisfy.kiae.su!Gamma.RU!srcc!newsserv From: "Aleksey M. Titov" Newsgroups: bionet.biophysics Subject: I wont to change laser therapy apparatuses "MUSTANG" to IBM computers. Date: 16 Jul 1996 19:38:44 +0400 Organization: Private Site Lines: 7 Distribution: world Message-ID: Reply-To: gta@technica.msk.ru NNTP-Posting-Host: crocus.gamma.ru X-Return-Path: technica!technica.msk.ru!gta@gamma.srcc.msu.su I have the best in the world laser therapy apparatuses "MUSTANG" and I wont to change it to IBM computers. E-MAIL: gta@technica.msk.ru ~~~~~~~~~~~~~~~~~~~~~~~~~~~ Tel./Fax:(095)251-24-50 From owner-biophysics@net.bio.net Tue Jul 16 23:00:00 1996 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.biophysics Subject: IMPORTANT - BIOSCI Fundraising Update! Date: 17 Jul 1996 02:00:08 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 154 Sender: daemon@net.bio.net Distribution: world Message-ID: <199607170900.CAA15164@net.bio.net> NNTP-Posting-Host: net.bio.net BIOSCI is about halfway to its funding goal!! I'm interrupting the usual monthly posting of the BIOSCI miniFAQ to bring you up to date on BIOSCI fundraising progress, a topic of concern to your future use of this resource. Thank you in advance for taking the time to read this message carefully. Last year we announced that BIOSCI was going to adopt the U.S. Public Broadcasting System model to fund its operations after our DOE/NSF grant runs out later this year. Unlike PBS, we are not soliciting contributions from users; we are only selling ads on our Web pages solely to cover our operating costs. Our goal is to seek sponsorships until we build up an operating reserve of about $100,000 and then cease further promotions until we need to build the reserve back up. (The accountants among our readership will be familiar with the problem of deferred revenue which we can not safely utilize until ads have been displayed for a period of time.) We are only about halfway to our funding goal and need to raise further funds to avoid having to curtail services at net.bio.net. Fundraising is time-consuming, however, and we need your help as explained further below. Our operating costs consist of our network connection, phone lines, hardware maintenance (we will be getting newer and faster hardware soon!), plus 0.7 FTE of salaries covering UNIX systems admin, technical support, quality assurance, i.e., testing, of our system, and administrative costs (such as the time it takes to actually find/write/call potential sponsors and raise money!). Although the BIOSCI staff does get compensated for a portion of the work that they do, this project has always received a lot of free after-hours and "vacation" time labor, so we hope that no one will begrudge the time that we do charge to the project to serve you. All of the three part-time staff members, Dave Mack, Julie Lawrence, and myself, have full time day jobs and families in addition to working hard to keep this service running for all of you. Julie and Dave Mack are subcontractors for BIOSCI; my time that is charged to the project defrays a portion of my regular salary instead of adding to my income. Besides having to relocate the project, we were very busy this last year building new infrastructure such as our WWW hypermail interface to the system. This was released last December along with scores of WAIS indices for the newsgroups. Virtually everything is complete, although we do continue to find and fix bugs (many through your helpful feedback!). We are still having some problems with our WAIS indexing. The archives continue to grow rapidly. We are running over 100 indexes now versus three previously and any systems crashes cause greater havoc with the indexing than before! We are still working to fix this as fast as our resources permit and appreciate your patience, but we have been able to automate a lot of the infrastructure to reduce labor as compared to past requirements. We have also implemented new software to make moderation of BIOSCI/bionet newsgroups much easier and combat the growing problem of Internet junk mail and USENET "spamming." About 20% of our groups are now moderated, many of them by the BIOSCI staff! This, for example, made a major difference last year in the quality of content in our EMPLOYMENT/bionet.jobs.offered newsgroup which many commercial concerns and recruiting firms are using **without charge** to recruit candidates for positions in the biological sciences. We are also now in a position to have sponsors for individual newsgroups as you will have noticed if you have visited http://www.bio.net/ and clicked on "Access the BIOSCI/bionet newsgroups" recently. So, how can you help?? ---------------------- As noted above it can take a lot of time to contact potential sponsors if I have to do it all myself. Our request is quite simple. You can do two important things which will take very little time for you individually. First, please use our WWW system at http://www.bio.net/ to access the archives. You can now post or reply to messages via your Web browser. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. Our hope is to quickly raise several large corporate/institutional sponsors on our heavily-used WWW locations (some stats appended below), and then end this sponsorship campaign so that our resources can continue to be used for service provision, not fundraising. Many of our specialty newsgroup WWW archives are still used by small communities of scientists (and they haven't been heavily promoted yet). While these may be valuable niche markets to some advertisers, it will generate more labor and overhead having to find these sponsors, fairly price the locations, and deal with lots of smaller sponsorships than fewer mid-to large sponsors. We are striving to keep our operation as lean and efficient as possible since we are not trying to make careers out of running BIOSCI. We are trying if at all possible to avoid the administrative overhead entailed with processing lots of small payments to reach our fundraising goals. I'd like to thank all of you for your help in advance. In helping us, you are also helping yourselves, not only in keeping this resource available for all of the both large and small research communities that we serve, but also by alleviating the need for us to go back and compete with researchers for tight grant dollars! We promised NSF when we were awarded the BIOSCI grant that we would carry out this mission to make the service self-supporting. With your help, we will succeed in continuing BIOSCI's work into its second decade. Thank you very much! Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net A list of our prime WWW sponsorship locations follow. Please contact us for further details. ---------------------------------------------------------------------- The overall BIOSCI WWW pages are currently visited by users from close to 5500 unique computer hosts per week. Web servers only log the Internet computer/host name and frequently more than one individual can connect to us from a particular host. Main home page, http://www.bio.net, visited recently by about 2100 unique hosts per week Main Newsgroups archives page, http://www.bio.net/archives.html, visited recently by about 1200 Unique hosts per week BIO-JOURNALS archive page, http://www.bio.net/BIO-JOURNALS.html, visited recently by about 1000 unique hosts per week. EMPLOYMENT archive pages: http://www.bio.net:80/hypermail/EMPLOYMENT/ and monthly header pages, visited recently by about 800 unique hosts per week. Address database search page, http://www.bio.net/addrsearch.html, visited recently by about 450 unique hosts per week. Methods newsgroup archive pages, http://www.bio.net:80/hypermail/METHDS- REAGNTS/ and monthly header pages, visited recently by about 350 unique hosts per week. Ads can also be displayed on various combinations of other BIOSCI/bionet newsgroups. Please contact us at biosci-help@net.bio.net for details. ---------------------------------------------------------------------- From owner-biophysics@net.bio.net Tue Jul 16 23:00:00 1996 Path: biosci!biosci!not-for-mail From: jain@arris.com (Ajay Jain) Newsgroups: bionet.biophysics,bionet.general,bionet.molec-model Subject: Call for Abstracts: PSB Molecular Docking Session Date: 17 Jul 1996 13:55:29 -0700 Organization: ARRIS Pharmaceutical, South San Francisco, CA Lines: 73 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Xref: biosci bionet.biophysics:2158 bionet.general:22795 bionet.molec-model:1054 **************************Call for Abstracts***************************** Molecular Docking: Lead Discovery and Optimization Pacific Symposium on Biocomputing (http://cgl.ucsf.edu/psb) Ritz-Carlton Kapalua, Maui, Hawaii January 6-9, 1997 CoChairs: Dr. Ajay N. Jain and Dr. Will Welch Arris Pharmaceutical Corporation The Pacific Symposium on Biocomputing (PSB-97) is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. We are currently soliciting abstracts for a poster session that will focus on computational techniques for molecular docking applied toward lead discovery and optimization. The rapidly increasing availability of structural information for biologically relevant enzymes and receptors has put molecular docking techniques on the critical path for modern drug discovery. The session is intended to cover both algorithmic aspects of docking and application of docking techniques to drug targets. Particular emphasis in the algorithmic area will be on methods for flexible docking, novel scoring functions, and on methods for protein analysis and characterization. Emphasis in the application areas will be on real-world use of docking techniques and assessment of their value as lead discovery and optimization tools. Contributions which introduce or illustrate novel computational methods and which present contemporary applications are equally encouraged. INSTRUCTIONS FOR SUBMISSIONS The Molecular Docking session will be a poster session with an opportunity for semi-structured discussion. We request submission of abstracts of up to two pages adhering to the guidelines set forth on the PSB web pages, which will be distributed at the meeting separately >From the archival proceedings. Important dates ------------------------------------------------------------------------ August 15, 1996 1-2 page abstract due August 31, 1996 Notification of accepted abstracts Submissions to this session or questions may be sent either electronically (preferred) or by standard mail to: Dr. Ajay N. Jain OR Dr. Will Welch Arris Pharmaceutical Corporation 385 Oyster Point Blvd., Suite 3 South San Francisco, CA 94080 jain@arris.com, welch@arris.com Tel (415) 829-1016 (Jain), x1014 (Welch) Fax (415) 829-1001 For more information on the Pacific Symposium on Biocomputing, please see our web site at http://cgl.ucsf.edu/psb or contact: Ms. Sharon Surles PSB Coordinator Interactive Simulations, Inc. 5330 Carroll Canyon Road, Suite 203 San Diego, CA 92121 psb@intsim.com Phone: +1 (619) 658-9782 FAX: +1 (619) 658-9463 ****************************************************************************** From owner-biophysics@net.bio.net Wed Jul 17 23:00:00 1996 Path: biosci!bcm.tmc.edu!watson!amcgough From: amcgough@bcm.tmc.edu (Amy McGough) Newsgroups: bionet.biophysics Subject: CALL FOR ABSTRACTS "Biomolecular Imaging" Date: 18 Jul 1996 22:26:23 GMT Organization: Baylor College of Medicine, Houston, Tx Lines: 70 Message-ID: <4smdmf$mlk@gazette.bcm.tmc.edu> NNTP-Posting-Host: bcm.tmc.edu NNTP-Posting-User: amcgough X-Newsreader: TIN [version 1.2 PL2] The abstract deadline for the Keck Center/ASBMB Fall Symposium has been moved to July 25. For those who are very interested in submitting but who may require a few additional days, please contact Marc Archambault (march@bioc.rice.edu) to inquire about an extension. CALL FOR ABSTRACTS *** SYMPOSIUM ANNOUNCEMENT "Computational Biology: Methods in Biomolecular Imaging" an American Society for Biochemistry and Molecular Biology Fall Symposium, Co-Sponsored by the W. M. Keck Center for Computational Biology, Houston, TX DATE & LOCATION: 25-28 October 1996, Whistler, British Columbia, Canada WEB SITES: http://www.faseb.org/meetings/asbmb/asbmbhp.htm AND http://ncmi.bioch.bcm.tmc.edu/~amy/ASBMB.html Organized by Kathleen S. Matthews, Rice University; Wah Chiu, Baylor College of Medicine; B. Montgomery Pettitt, University of Houston; and George N. Phillips, Jr., Rice University Keynote Address, Michael Rossmann, Purdue University Experimental Structural Methods, Keith Moffat, University of Chicago Computational Structural Methods, George Phillips, Jr., Rice University Experimental Imaging Methods, Wah Chiu, Baylor College of Medicine Computational Imaging Methods, Gerard Bricogne, Medical Research Council, Cambridge, UK Graphics & Visualization, Bridget Carragher, University of Illinois, Urbana Other Invited Speakers include: Michael Pique, Scripps Research Institute Axel T. Brunger, Yale University Kenneth H. Downing, UC, Berkeley Helen Hansma, UC, Santa Barbara Wayne A. Hendrickson, Columbia University Richard Tapia, Rice University L. Ridgway Scott, University of Houston Marin van Heel, Imperial College, London Edgar Weckert, Universitaet Karlsruhe Kurt Wuthrich, ETH Zurich Abstract Deadline: July 25, 1996 (direct inquirys about extensions to march@bioc.rice.edu) Room Reservations: September 25, 1996 Advance Registration: October 11, 1996 For more information contact: ASBMB 9650 Rockville Pike Bethesda, MD 20814-3998 FAX: (301) 530-7014 Telephone: (301) 530-7010 Email: gswindle@osmc.faseb.org or: Marc L. Archambault, Executive Director W. M. Keck Center for Computational Biology Rice University MS 141 6100 S. Main Street Houston, TX 77005 FAX: +1 (713) 527-4659 or +1 (713) 285-5454 Telephone: (713) 527-4752 E-mail: march@rice.edu From owner-biophysics@net.bio.net Thu Jul 18 23:00:00 1996 Path: biosci!agate!spool.mu.edu!usenet.eel.ufl.edu!warwick!lyra.csx.cam.ac.uk!news.ox.ac.uk!news From: "Simon M. Brocklehurst" Newsgroups: bionet.biophysics Subject: NAOMI software Date: Fri, 19 Jul 1996 12:16:56 +0100 Organization: University of Oxford Lines: 44 Message-ID: <31EF6EA8.167EB0E7@bioch.ox.ac.uk> NNTP-Posting-Host: nmrv.ocms.ox.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.01 (X11; I; SunOS 4.1.3_U1 sun4m) NAOMI - Message to users/prospective users _____________________________________________________________________________ Due to the large number of requests for NAOMI licenses in the last 2 months, there has been a delay in supplying license keys. This backlog, however, is now cleared. Because of the heavy influx of mail/e-mail, however, I think a few people's requests may have slipped through the net. If you contacted me more than 1 week ago, and have not yet received a reply I'd be grateful if you'd re-send your message. ----------------------------------------------------------------------------- NAOMI - for studying 3-D structures of proteins. NAOMI is available free of charge for academic users. NAOMI Version 2.4c is available as of now from the NAOMI Web site at: http://www.ocms.ox.ac.uk/~smb/Software/N_details/naomi.html or via anonymous ftp ftp://nmrz.ocms.ox.ac.uk/pub/smb/naomi i.e. at nmrz.ocms.ox.ac.uk in directory pub/smb/naomi/ ----------------------------------------------------------------------------- More information at the commercial Web site at: http://www.psynix.co.uk/products/naomi/index.html _____________________________________________________________________________ | | ,_ o Simon M. Brocklehurst, | / //\, Oxford Centre for Molecular Sciences, Department of Biochemistry, | \>> | University of Oxford, Oxford, UK. | \\, E-mail: smb@bioch.ox.ac.uk | WWW: http://www.ocms.ox.ac.uk/~smb/ |____________________________________________________________________________ From owner-biophysics@net.bio.net Thu Jul 18 23:00:00 1996 Path: biosci!GOLD.CHEM.HAWAII.EDU!shuilin From: shuilin@GOLD.CHEM.HAWAII.EDU (Shuilin Niu) Newsgroups: bionet.biophysics Subject: looking for aa sequence for fish Mb Date: 18 Jul 1996 23:22:11 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 7 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Hi, fellows: I'm trying to find the amino acid sequence for fish myoglobin (blue fin trevally). Can anybody tell me if there is any website where I can find the aa sequences? Thanks a lot! From owner-biophysics@net.bio.net Thu Jul 18 23:00:00 1996 Path: biosci!bcm.tmc.edu!pendragon!news.msfc.nasa.gov!newsfeed.internetmci.com!uwm.edu!usenet From: Hanqing Wu Newsgroups: bionet.biophysics Subject: Online EPR Spectrum Simulation through CGIEMAIL Date: Thu, 18 Jul 1996 20:14:21 -0700 Organization: Home Lines: 11 Message-ID: <31EEFD8D.CD7@alpha1.csd.uwm.edu> Reply-To: hanqing@alpha1.csd.uwm.edu NNTP-Posting-Host: 129.89.8.201 Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0b4Gold (Win95; I; 16bit) CC: hanqing@alpha1.csd.uwm.edu I have created a homepage of "Online EPR Spectrum Simulation through CGIEMAIL" at "http://www.uwm.edu/~hanqing/watoc/oleprsm.htm". Please look the page and give me suggestion. Two electronic posters on EPR simulation presented at WATOC96 can be seen at "http://www.ch.ic.ac.uk/watoc/abstracts/". Thanks! Hanqing Wu hanqing@alpha1.csd.uwm.edu From owner-biophysics@net.bio.net Thu Jul 18 23:00:00 1996 Path: biosci!agate!howland.reston.ans.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!news.mathworks.com!fu-berlin.de!news.dfn.de!news.ruhr-uni-bochum.de!news.rwth-aachen.de!news From: Ralf Vandenhouten Newsgroups: bionet.neuroscience,comp.dsp,sci.engr.biomed,bionet.biophysics,bionet.software,comp.software.international Subject: SOFTWARE SANTIS 1.1 for time series and signal analysis Date: Fri, 19 Jul 1996 14:30:26 +0200 Organization: Biomedical Systems Analysis Lines: 51 Message-ID: <31EF7FE2.3A1@physiology.rwth-aachen.de> NNTP-Posting-Host: uhura.physiology.rwth-aachen.de Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.0 (X11; I; SunOS 5.5 sun4m) Xref: biosci bionet.neuroscience:14937 comp.dsp:25432 sci.engr.biomed:6497 bionet.biophysics:2163 bionet.software:16136 comp.software.international:4155 SANTIS 1.1, the latest update of the SANTIS software package for signal processing and systems analysis, is now available. SANTIS is a tool designed for the analysis of signals and time series data of any kind, in particular for scientific purposes. It was developed at the Laboratory of Biomedical Systems Analysis (Institute of Physiology) at the University of Aachen, Germany. The guidelines for the design of SANTIS were: * Easy-to-use graphical user interface * State-of-the-art functionality for modern systems analysis * High level of integration of a wide variety of signal processing functions in a common interface * Support of standard hardware and software platforms Besides a large number of standard facilities for signal processing SANTIS provides many advanced features like wavelet techniques and methods of nonlinear dynamics. Among the new features of version 1.1 are: * Support of various signal file formats (binary and ASCII SANTIS formats, MegaWave, WAVE audio files, ASCII raw data) * Logarithmic scaling * Median and central moments * Integration * Mathematical functions * Improved display facilities for wavelets and wavelet transforms * Wavelet sure shrinking * 2D and 3D delay plots SANTIS 1.1 is free software for non-commercial users (if you are a professional user please contact me) and comes with full documentation. Currently it is available for Windows 3.1x, Windows 95, Windows NT, Linux, SUN Solaris 2, and Silicon Graphics Irix 5.3, and can be downloaded directly from the SANTIS WWW page http://www.physiology.rwth-aachen.de/santis/ or by anonymous ftp from our ftp-server ftp://ftp.physiology.rwth-aachen.de:/pub/santis You're very welcome, Ralf Vandenhouten -- Ralf Vandenhouten Phone: +49-241-8088826 or 8088804 Dept. of Physiology, RWTH Aachen FAX: +49-241-8888434 Pauwelsstr. 30, D-52057 Aachen mailto:vanni@Physiology.RWTH-Aachen.DE http://WWW.Physiology.RWTH-Aachen.DE/~vanni/ From owner-biophysics@net.bio.net Sun Jul 21 23:00:00 1996 Path: biosci!coldcure.com!coldcure From: coldcure@coldcure.com (George Eby) Newsgroups: bionet.biophysics Subject: Biophysics relationship to cure for Common Cold Date: 22 Jul 1996 13:06:32 -0700 Organization: GEORGE EBY RESEARCH Lines: 32 Sender: daemon@net.bio.net Distribution: world Message-ID: <31F3DE9E.1C60@coldcure.com> NNTP-Posting-Host: net.bio.net Please excuse this interuption, but since you and everyone else catches common colds, I think you won't mind the following announcement. Zinc lozenges as a treatment or cure for common colds have been controversial for over 10 years, ever since I published in Antimicrobial Agents and Chemotheraphy the original report in 1984. The July 15 issue of Annals of Internal Medicine article entitled "Zinc Gluconate Lozenges for Treating the Common Cold: A randomized, Double-Blind, Placebo-Controlled Study" (pages 81-88) by physicians at the Cleveland Clinic Foundation in Cleveland, Ohio, confirmed conclusively the value of zinc 2+ ions from lozenges in reducing the duration of common colds and all symptoms by about 50%. The zinc gluconate lozenges had an objectionable taste and aftertaste attributed to the formation of zinc gluconate-hydroxide species at pH 7.4. An editorial article by Ananda S. Prasad, MD, PhD, at Wayne State University (the father of zinc and human biochemistry) recommended using zinc acetate rather than zinc gluconate to avoid the taste problem. My company has been producing zinc acetate lozenges [Fast Dry(TM) Lozenges] for several years, and they are available to INTERNET users through our WEB site at http://www.coldcure.com/ Find out why human biophysics (the mouth nose biologically closed electric circuit) concealed the cure for the common cold for 100 years. Click on the link entitled "Late Breaking News from the Annals of Internal Medicine for a report on this new research, my comments about it and solution chemistry calculations that lead to the determination of the zinc ion availability value, the primary determinant of efficacy of zinc lozenges in the treatment of common colds. BE PREPARED FOR YOUR NEXT COLD, ORDER FAST DRY(TM) lOZENGES AND SAVE YOURSELF 5 TO 7 DAYS OF MISERY! George Eby, Austin, Texas http://www.coldcure.com/ 70+ pages of data From owner-biophysics@net.bio.net Sun Jul 21 23:00:00 1996 Path: biosci!rutgers!uwm.edu!newsspool.doit.wisc.edu!scooby.beloit.edu!jungck From: jungck@beloit.edu (John Jungck) Newsgroups: bionet.biophysics Subject: nucleic acid hydrophobicities Date: 22 Jul 1996 19:22:01 GMT Organization: Beloit College Lines: 8 Message-ID: <4t0kcp$g0k@scooby.beloit.edu> Reply-To: jungck@beloit.edu NNTP-Posting-Host: beloit.edu X-Newsreader: TIN [version 1.2 PL2] Would anyone have measurements of nucleic acid hydrophobicities? Data obtained by any method would be helpful. Please reply to allikian@stu.beloit.edu. Thank you in advance. -Qat From owner-biophysics@net.bio.net Sun Jul 21 23:00:00 1996 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!newsfeed.internetmci.com!solaris.cc.vt.edu!usenet From: whouck@vt.edu (Bill) Newsgroups: bionet.microbiology,bionet.biophysics Subject: Shear threshold? Date: 22 Jul 1996 13:19:14 GMT Organization: Virginia Tech Lines: 20 Message-ID: <4svv4i$ek4@solaris.cc.vt.edu> NNTP-Posting-Host: as2511-10.sl015.cns.vt.edu X-Newsreader: WinVN 0.92.1 Xref: biosci bionet.microbiology:6651 bionet.biophysics:2165 Could anyone tell me where I might be able to find the shear stress threshold for various common cell types? I am currently faced with the problem of optimizing production in a bioreactor containing immobile cells. If you know of a journal or text which might have this information, please let me know. In particular, Bowes Melanoma cells, but any of the more common cultured cells (plants included) would be helpful. Thanks. Bill Houck VPI&SU "Virginia Tech" President, Va Tech Biomedical Engineering Society Dept. of E.S.M. ************************************** * Everything you know is wrong! * * * * - the floating, disembodied* * head of Colonel Sanders * ************************************** From owner-biophysics@net.bio.net Sun Jul 21 23:00:00 1996 Path: biosci!ucsusa.ucsusa.org!goetze From: goetze@ucsusa.ucsusa.org Newsgroups: bionet.biophysics Subject: Re: Biophysics relationship to cure for Common Cold Date: 22 Jul 1996 16:31:50 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 21 Sender: daemon@net.bio.net Distribution: world Message-ID: <9606228380.AA838080611@ucsusa.ucsusa.org> NNTP-Posting-Host: net.bio.net dear colleagues, though i hate to respond to spam, as it can lead to an unproductive continuation of rubbish, i will in this case in the interests of safety. zinc has a fairly long history of medical use, including treatment of accute sinusitus, persistant infection and, according to one source, even syphillus. however, it should be noted that prolonged dietary supplementation of zinc (ie >325mg/day for longer than 1wk) can lead to immunosuppression (Murray and Pizzorno, "Encyclopedia of Natural Medicine", 1991). this important pre-caution was not mentioned in g. eby's posting. if you are annoyed by that message (or this one), pls flame him, not me. good health, Darren Goetze From owner-biophysics@net.bio.net Mon Jul 22 23:00:00 1996 Path: biosci!BIOCIB.CIB.NA.CNR.IT!camus From: camus@BIOCIB.CIB.NA.CNR.IT (Carlo Musio) Newsgroups: bionet.biophysics Subject: International Schools on Biophysics and Biocybernetics Date: 23 Jul 1996 05:26:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 251 Sender: daemon@net.bio.net Distribution: world Message-ID: <199607231122.NAA08644@biocib.cib.na.cnr.it> NNTP-Posting-Host: net.bio.net PLEASE CIRCULATE ISTITUTO ITALIANO PER GLI STUDI FILOSOFICI promotes and supports the Study Program on UPWARD AND DOWNWARD CONTRIBUTIONS TO THE PERCEPTION PROCESSES articulated in two International Schools International School of Biophysics "FROM STRUCTURE TO INFORMATION IN SENSORY SYSTEMS" Isle of Ischia (Naples), Italy October 14-19, 1996 Opening Ceremony: Naples, morning of October 14, 1996 International School of Biocybernetics "DOWNWARD PROCESSES IN THE PERCEPTION REPRESENTATION MECHANISMS" Isle of Ischia (Naples), Italy October 21-26, 1996 Opening Ceremony: Naples, morning of October 21, 1996 SCHOOLS' DIRECTOR Cloe Taddei-Ferretti Istituto di Cibernetica, CNR LOCAL ORGANIZING COMMITTEE Antonio Cotugno Carlo Musio Salvatore Piantedosi Silvia Santillo Istituto di Cibernetica, CNR ORGANIZING INSTITUTE Istituto di Cibernetica, CNR Via Toiano, 6 I-80072 Arco Felice (NA), Italy Tel: +39-81-8534113/131 Fax: +39-81-5267654 OTHER SUPPORTERS National Group of Cybernetics and Biophysics, Italian National Research Council (GNCB, CNR) INTERNATIONAL SCHOOL OF BIOPHYSICS "FROM STRUCTURE TO INFORMATION IN SENSORY SYSTEMS" Isle of Ischia, Naples, Italy October 14-19, 1996 ADVISORY BOARD Carr (USA), Lancet (IL), Paul (CAN), Stieve (D), Torre (I), Van Houten (USA) INVITED LECTURERS AMONG OTHERS Session I - Chemoreceptive Systems and Chemotransductive Processes W.E.S. Carr (USA) 1. The role of chemical senses and specific chemicals in controlling different facets of the behavior of aquatic animals 2. Receptor and perireceptor components of chemosensory systems A. Cavaggioni (I) 1. Olfaction. I 2. Olfaction. II D. Lancet (IL) 1. Olfaction: from receptor genes to neural information processing. Molecular recognition and trasduction in olfactory system 2. Olfaction: from receptor genes to neural information processing. Neuronal processing of molecular shape information Session II - Mechanoreceptive Systems and Mechanotransductive Processes M. Juusola (FIN) 1. Signal encoding in spider slit-sense organ mechanoreceptor neurons H.Machemer (D) 1. Mechano-sensorimotor organization in the Ciliate organism. Basis 2. The dealing with gravity at the unicellular level. Concepts and data G.K. Yates (ASL) 1. Mechanical signal conditioning in the mammalian cochlea: linear processes 2. Mechanical signal conditioning in the mammalian cochlea: non linear processes D.C. Wood (USA) 1. Mechanisms of mechanoreception. The place of a small organism in the big picture Session III - Photoreceptive Systems and Phototransductive Processes T. Gotow (JAP) 1. Depolarizing and hyperpolarizing receptor potentials of the molluscan extra-ocular photoreceptor cells 2. Cyclic GMP-activated K+ channels of the molluscan extra-ocular photoreceptor cells K.G. Goetz (D) 1. Processing of visual information in the fruitfly Drosophila. I 2. Processing of visual information in the fruitfly Drosophila. II H.C. Hardie (UK) 1. Properties of the light-sensitive channels in Drosophila 2. The role of Ca++ in Drosophila phototransduction M. Juusola (FIN) 2. Processing visual information by graded potential transmission in blowfly photoreceptor-LMC synapses E. Nasi (USA) 1. Visual excitation mechanisms in rhabdomeric photoreceptors: multiple light-dependent channels, ion permeation and gating 2. Bridging the gap between vertebrate and invertebrate phototransduction: the light-activated conductance in molluscan hyperpolarizing photoreceptors H. Stieve (D) 1. Phototransduction in Invertebrates and Vertebrates. Structure-function relation D.C. Wood (USA) 2. Photophobic responses in Stentor and Blepharisma from an electrophysiological perspective INTERNATIONAL SCHOOL OF BIOCYBERNETICS "DOWNWARD PROCESSING IN THE PERCEPTION REPRESENTATION MECHANISMS" Isle of Ischia, Naples, Italy October 21-26, 1996 ADVISORY BOARD Berlucchi (I), Glezer (CSI), Ingvar (SW), Libet (USA), Poeppel (D), Pribram (USA) INVITED LECTURERS AMONG OTHERS Session I - Perception and Representation T. Bachmann (EE) 1. The theory of perceptual retouch in explaining the dynamics of visibility of brief visual images 2. Some empirical tests for the predictions derived from the theory of perceptual retouch G. Basti (I) 1. Neural images and neural coding V.D. Glezer (CSI) 1. Two mechanisms of visual cortex. Spatial frequency analysis and primitives 2. The role of this mechanisms in abstract and full description of image in different hemispheres D.H. Ingvar (S) 1. A top-down model for language perception and production A. Perrone (I) 1. Information coding in the brain T. Radil (CZ) 1. Descendent control of perception R. Sekuler (USA) 1. Motion perception. General introduction 2. Motion perception. Cooperation between top-down and bottom-up influences S. Ullman (IL) 1. Visual object recognition 2. Bottom-up and top-down processing in the visual cortex N. Troje (D) 1. Generalization to novel views of faces. Psychophysics and models 2. Representations of human faces Session II - The Unconscious and Consciousness D.H. Ingvar (S) 2. A "kantian" model of consciouness B. Libet (USA) 1. Neural time factors in cerebral mediation of conscious vs. unconscious sensory perception 2. Unconscious cerebral initiative and the role of conscious will in voluntary action T. Radil (CZ) 2. Conscious and unconscious olfaction Session III - Mental Events K.H. Pribram (USA) 1. Comprehension: the contributions of the posterior cerebral convexity in enhancing processing span 2. Envisioning properties, priorities and pratical influences: the far frontal cortex as executive processor T. Radil (CZ) 3. A philosophical frame from neuroscience AIM OF THE SCHOOLS The Schools are foreseen as training for young researchers while bringing up to date the experienced ones, by means of both formal lectures and discussions. SCHOOL(S) FEE The fee for one School is Lit (Italian Lire) 850,000, for both Schools is Lit 1,500,000. The fee includes full board and lodging in Ischia (arranged by the School Organization) from the dinner of (the first) Monday to the lunch of (the last) Saturday, the lunch(es) of Monday(s) in Naples after the Introductory lecture(s), coffee breaks, social dinner(s), touristic excursion(s), programme(s), abstract booklet(s), and proceedings' volume(s). The fee must be payed by bank transfer to: "Bio School", account no. 8059002, Banca Commerciale Italiana, Filiale Fuorigrotta, SWIFT BCIT IT MM 514, ABI 2002, CAB 3412, Piazza San Vitale 13, Napoli, Italy. GRANTS Limited support can be granted at the end of each School to some students of deserving countries who need financial help. Those wishing to apply for a grant should submit a request, together with the Registration Form, and with a letter of the Head of the Department of affiliation confirming the impossibility to provide a total support. LODGING The Schools are residential; both, the invited lecturers and the other participants are grouped in the same location (a few minutes walk distance from the sea), in order to promote discussion also after the lecture time. The single rooms will be reserved for the early registrations. The instructions to reach the hotel will be sent to regularly registered participants. Full board and lodging for extra days and/or for accompanying person(s) is Lit 100,000 per day and per person. For those wishing to stay some more days, one can add that the isle of Ischia is close to Naples, Capri, Sorrento, Vesuvio, Pompei, Paestum, Cuma. ABSTRACT Participants may offer, in the form of oral presentation (5-10 min), the results of their own current researches. Applicants should submit to the Director of the Schools one A4 page abstract, in order to be included among the lecturer abstracts, which will be distributed at each School. Furthermore, a short paper (max four A4 pages, prepared according to the instructions that will be sent to the applicants) can be submitted, in order to be published in the proceeding volume, with the lecturer papers, by an international editing company. The paper will be placed under the judgment of the Advisory Board, which reserves the right of rejecting papers non suitable for publication. DEADLINES Deadline for registration: August 5, 1996. Deadline for accommodation: August 5, 1996. Deadline for abstract submission: August 5, 1996. Deadline for paper submission: September 20, 1996. A copy of the Bank Receipt of the Fee Payment as well as the Registration and Accommodation Forms must be returned within July 5, 1996 to: Carlo Musio, Antonio Cotugno or Silvia Santillo of the Local Organizing Committee Istituto di Cibernetica, CNR Via Toiano 6 I-80072 Arco Felice (NA), Italy Tel.: +39-81-8534113/8534131 Fax: +39-81-5267654 E-mail: neuros@mail.irtemp.na.cnr.it REGISTRATION FORM Name(s) of the School(s) Name First Name Male Female Position or Title Company Address Tel Fax E-mail I payed the sum of Lit 1,200,000 / 550,000 (bank tax excluded) [circle the right item] for part of the School(s) registration (a copy of the payment document is enclosed). I will pay the last Lit 300,000 on my arrival in order to complete my registration. Signature ACCOMMODATION FORM Please reserve/do not reserve [circle the desired item] for me no. ...... extra days before the School(s), no. ....... extra days after the School(s). Please reserve/do not reserve [circle the desired item] no. ...... days for no. ...... accompanying person(s); arrival ...... , departure ...... . I will pay all the extra days directly to the Hotel. Signature Date From owner-biophysics@net.bio.net Mon Jul 22 23:00:00 1996 Path: biosci!LEX.LCCC.EDU!rcb1 From: rcb1@LEX.LCCC.EDU (Ron Blue) Newsgroups: bionet.biophysics Subject: Re: Biophysics relationship to cure for Common Cold Date: 23 Jul 1996 09:20:41 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 18 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <9606228380.AA838080611@ucsusa.ucsusa.org> NNTP-Posting-Host: net.bio.net On 22 Jul 1996 goetze@ucsusa.ucsusa.org wrote: >>>>CUT>> > even syphillus. however, it should be noted that prolonged dietary > supplementation of zinc (ie >325mg/day for longer than 1wk) can lead > to immunosuppression (Murray and Pizzorno, "Encyclopedia of Natural > Medicine", 1991). this important pre-caution was not mentioned in g. > eby's posting. >>>>CUT>> I agree that zinc is toxic at high doses. But a study of giving 200mg per day which I feel is unsafe resulted in no toxic effects. I like the rule of 6 times the RDA as being a health amount. So 15mg RDA times 6 equals 90 mg. Since you can not buy 90 mg dose I use 100 mg for the last 10 years. My doctor gets upset that he rarely see me. My understanding on the cold was that the zinc was worthless if taken internally and was worthless after the cold developed. It was valuable to stop a cold as it was starting up. Ron Blue From owner-biophysics@net.bio.net Tue Jul 23 23:00:00 1996 Path: biosci!agate!newsgate.duke.edu!solaris.cc.vt.edu!homer.alpha.net!uwm.edu!news.cse.psu.edu!rutgers!csn!nntp-xfer-1.csn.net!magnus.acs.ohio-state.edu!lerc.nasa.gov!purdue!haven.umd.edu!news.ums.edu!umabnet.ab.umd.edu!news From: pdelaney@anesthlab.ab.umd.edu (Paul A. Delaney) Newsgroups: bionet.biophysics Subject: Re: looking for aa sequence for fish Mb Date: Wed, 24 Jul 1996 13:25:05 GMT Organization: UMAB Anesthesiology Lines: 31 Message-ID: <4t57i1$ro9@trout.ab.umd.edu> References: NNTP-Posting-Host: anesth07.ab.umd.edu X-Newsreader: Forte Free Agent 1.0.82 shuilin@GOLD.CHEM.HAWAII.EDU (Shuilin Niu) wrote: >Hi, fellows: > I'm trying to find the amino acid sequence for fish myoglobin >(blue fin trevally). Can anybody tell me if there is any website where I can >find the aa sequences? > Thanks a lot! You might be interested in NIH Molecular Modeling stuff: http://cmm.info.nih.gov/modeling/quick_finder.html particularly "Molecules R Us". Basically you type in a text pattern, the host searches through its database, and draws the appropriate molecules in a variety of methods (eg, space filled, ball & stick). The files used to draw these things MUST contain the amino acid sequences (I've seen them before, but can't remember quite how). While you can scope out these pix via your browser, you'll get a lot more information by downloading the PDB Viewer helper application from the same sight. Maybe this won't help you, but it's pretty neat seeing these molecules! ---------------------------------------------------------------- Paul A. Delaney, Biomedical Physicist (Anesthesiology) U of MD Medical Systems and Medical School R Adams Cowley Shock Trauma Center Baltimore, Maryland 21201 From owner-biophysics@net.bio.net Tue Jul 23 23:00:00 1996 Path: biosci!rutgers!uwm.edu!news-res.gsl.net!news.gsl.net!hunter.premier.net!news.cais.net!news.ac.net!news.bconnex.net!news2.insinc.net!roger.interlynx.net!news From: lthomsen@interlynx.net (Lars Thomsen) Newsgroups: bionet.biophysics Subject: Nerst equilibrium potential and patch clamp configurations ? Date: Tue, 23 Jul 1996 16:52:47 GMT Organization: Interlynx Lines: 77 Message-ID: <4t5a9b$bho@roger.interlynx.net> NNTP-Posting-Host: ppp20-max2.interlynx.net X-Newsreader: Forte Free Agent 1.0.82 Dear Reader I have a problem which I find very tricky, but first a short introduction to the problem INTRODUCTION The Nernst equilibrium potential for potassium at physiological conditions is given by following equation : Ek= E0 - (RT/zF)LN([K]inside/[K]outside) R= 8.314 J/K·mol T=absolute temp in Kelvin (=298 K at 25 C) z= charge of the ion F=Faradays constant 96500 C/mol in many physiological books they state that E0=0 and they use the reversed ratio [K]out/[K]in and therefore they get rid of the minus in front of the equation and ends with : Ek= RT/zF ln([K]out/[K]in) , with [K]out = 5 and [K]in = 100 we get Ek= 0.0256 * LN(5/100) = -0.077 Volt The conditions for this equation is that outside the cell is defined as zero. THE PROBLEM We have defined outside as zero and outside is therefore our reference point. In the recording situation where we have a ground connection to the amplier made by a Ag/AgCl electrode I assume that that is our reference point and the potential in the cell to this point is the cells membrane potential. This works very well when we measure in the whole cell or out-side-out configuration, but what about the in-side-out configuration ? In the in-side-out configuration we will have our reference point in the inside solution and we will have the recording electrode in the outside solution. If we calculate the Nernst potential for [K]in = 5 in respect to the ground, but [K]in = 100 in respect to the cytoplasmatic side (just as before) [K]out = 100 in respect to the recording electrode, but [K]out = 5 mM in respect to the external side of the cell membrane. A) Ek = 0.0256 * LN(out/in) = 0.0256 * LN(100/5) = 0.077 or B) Ek= 0.0256 * LN(out/in) = 0.0256 * LN(5/100) = -0.077 If B is right, then I can't understand what happened to the reference point (our ground) and why it doesn't report the inverted potential. Best Regards Lars Thomsen Lars Thomsen, MSc. PhD. 115 South Oval, Hamilton L8S1R2 Ontario Canada tlf : +1 905 777 0720 fax : +1 905 777 0738 email : lthomsen@interlynx.net homepage : http://home.interlynx.net/~lthomsen/index.htm McMaster University, Intestinal Disease Research Program From owner-biophysics@net.bio.net Thu Jul 25 23:00:00 1996 Path: biosci!bloom-beacon.mit.edu!spool.mu.edu!uwm.edu!cs.utexas.edu!swrinde!elroy.jpl.nasa.gov!news.msfc.nasa.gov!newsfeed.internetmci.com!in2.uu.net!news.i-link.net!usenet From: Karl Kortemeyer Newsgroups: bionet.biophysics Subject: Advanced Water Sciences Symposium Date: 26 Jul 1996 03:11:19 GMT Organization: I-Link Inc Lines: 155 Message-ID: <4t9d0n$130o@news.i-link.net> NNTP-Posting-Host: dallas-1-9.i-link.net Registration Information Second Annual Advanced Water Sciences Symposium October 4 - 6, 1996, Dallas, Texas Sponsored by Institute for Advanced Water Sciences Research and the Seraph Foundation Below is the registration information for the Advanced Water Sciences Symposium (AWS96) to be held in Dallas, TX, October 4-6, 1996. See the list of confirmed invited speakers and see the preliminary schedule of technical sessions. The conference registration form and payment should be sent in by Friday, September 6, 1996 to qualify for the early registration discount. Please make your own hotel reservations directly with the hotel by Friday, September 13, 1996 to be included in reserved block of rooms. This conference/symposium is hosted by the Institute for Advanced Water Sciences Research. IAWSR is a not for profit membership association dedicated to the promotion of advanced water sciences and the free exchange of ideas that contribute to the advancement of water science. IAWSR and the symposium provide a forum for members and contributing individuals to exchange ideas in the following water related subjects: Hard Science: hydrodynamics, water purification technology, electrolysis, bond angle relationships and energy states, environmental issues, photo chemistry, ionics, ORP, chemistry, oxidative states in water. Interdisciplinary: vortex mechanics, magnetic resonance in water, liquid crystal states, advanced ozonation, colloidal chemistry, structured water, homeopathic effects in relationship to energized water, radio frequency effects on water, energization states in water, magnetic field effects on water dynamics and structure, energy systems utilizing water dynamics or structure. Exploratory: subtle energy effects in water, consciousness and water, effects of harmonic geometries on water, scalar wave effects on water, energization and transformation in the water molecule, memory in water states, biological effects of energized and structured water. Confirmed invited speakers: Joseph Bender: keynote speaker "Water: the Bigger Picture", and also Jim Beal, Ron Carson, Dr. Lee Cowden, Prof. Carlton Hazlewood, Dr. Stuart Hameroff, Dr. Tony Scott-Morley MD, Prof. Elizabeth Rauscher, Dr. William Rea, Glen Rein, Prof. James Roberts, Joseph Tyls. Send registration form from below and payment to: Second Advanced Water Sciences Symposium P.O. Box 1295 Dallas, Texas 75355-1295 fax: (214) 827-6575 email: seraph@metronet.com For more information: phone (214) 682-9162 or see symposium web site at http://vitalenergy.com/water. ADVANCED WATER SCIENCES SYMPOSIUM TRANSPORTATION IAWRS has arranaged a 5% fare discount for the symposium with American Airlines. Call the AA meetings services desk at 1-800-433-1790 and tell them your desired AA flights. Give them the Star File number S2506AE, and they will book your flight with a 5% discount. Rental Cars: All of the major car rental companies serve both Dallas airports, although only Avis, National, Hertz, and Budget are on-site at DFW. Ask for directions to The Bristol/Harvey Hotel at the rental desk. Obtain Avis discount of 5% when using group discount number D004278. Airport/Hotel Shuttles: Super Shuttle provides van shuttles to/from the symposium hotels. The taxis or vans are available outside the terminals on the lower level at DFW, and in front of the main terminal at Love Field. Estimated distance to the hotel from DFW is about 15 miles, and from Love field is about 12 miles. Phone number for van service directly to hotel is: Super Shuttle: (800) 258-3826 [BLUE-VAN]; to/from DFW $12.00 per person; to/from Love Field $15.00 per person. Visa/MC/AMEX/Diners Club accepted. HOTEL REGISTRATION/ACCOMMODATIONS All AWS symposium events will be held at the Bristol Suites, 7800 Alpha Road, Dallas, TX, (one block NW from corner of Highway 635 & Coit Road). We have reserved a block of rooms at both Bristol Suites and at the adjacent Harvey Hotel. Reservations and room guarantee should be made directly with the hotel of your choice at the following numbers: date: Friday September 13 (***Deadline when block of rooms released***) (Ask for Advanced Water Sciences Symposium Group Rate) mail: Bristol Suites or mail: Dallas Harvey Hotel 7800 Alpha Road 7815 LBJ Freeway (Highway 635) Dallas, Texas 75240 Dallas, Texas 75251 rate: US$89 (single or double) rate: US$59 (single or double) US$99 (triple or quadruple) US$69 (triple or quadruple) Includes full breakfast room only fone: (214) 233-7600 fone: (214) 960-7000 fax: (214) 701-8618 fax: (214) 788-4227 ADVANCED WATER SCIENCES SYMPOSIUM REGISTRATION The early registration fee is $175 before September 6 and the on site registration fee of $250 applies after that date. A student discount registration fee will be $100. Registration fee includes Friday evening reception, access to all technical sessions (all day Saturday and half day Sunday), Saturday lunch, and one copy of proceedings. IAWSR will accept both checks and all major credit cards for registration. We can accept payment by CHECK drawn from US banks or US money order payable to Advanced Water Sciences Symposium. To aid in our planning, PLEASE REGISTER AND PAY IN ADVANCE because we have a maximum number of people we can accomidate at the conference. A registration table will be set up at the Friday evening reception, and before the Saturday morning keynote session. Please stop by to register and pick up your registration packet, including a copy of proceedings. Additional proceedings can be preordered. Information about the location of the reception and symposium talks will be available at the hotel check-in desk. ----------------------------------- cut here ---------------------------------- REGISTRATION FORM for Advanced Water Sciences Symposium, Dallas, Texas, Oct. 4-6, 1996 Send to P.O. Box 1295, Dallas, Texas 75355-1295 or FAX: (214) 827-6575 or email: seraph@metronet.com NAME/TITLE:_________________________________ AFFILIATION:______________________ MAILADDRESS:_______________________________ MAILCITY/STATE/ZIP:________________ TELEPHONE:____________________________________FAX:_____________________________ EMAIL ADDRESS:_________________________________________________________________ TOPICS OF INTEREST:____________________________________________________________ I PLAN TO ATTEND AWS: YES___ NO___ THE RECEPTION FRIDAY EVENING: YES___ NO___ I PLAN TO STAY IN DALLAS AT: Bristol Suites ____ Harvey Hotel ____ Other _____ ANY SPECIAL DIETARY REQUIREMENTS:______________________________________________ *****************************Payment Information*************************** Registration fee ($175 before Sept. 6)or($250 on site)or($100 student)_________ add Number of ADDITIONAL AWS Proceedings at $25.00 each _________ add IAWSR membership special conference rate of $25 per year _________ TOTAL FEE DUE: _________ CHECK ENCLOSED FOR (made payable to Advanced Water Sciences Symp): _________ I AUTHORIZE PAYMENT OF ABOVE TOTAL FEE USING CREDIT CARD INFO BELOW: CREDIT CARD NUMBER:___________________________________________________ CREDIT CARD TYPE: _________________ EXPIRATION DATE:_________________ (receipts will be included in conference packets) (all registrations will be confirmed within 2-3 days) ----------------------------------- cut here ------------------------------ The Institute for Advanced Water Sciences Research will be setting it's own Web site in the future. From owner-biophysics@net.bio.net Thu Jul 25 23:00:00 1996 Path: biosci!ihnp4.ucsd.edu!munnari.OZ.AU!bunyip.cc.uq.oz.au!news From: "Venus 'N' Pengo" Newsgroups: bionet.biophysics Subject: Could u please help me find...................... Date: Fri, 26 Jul 1996 22:54:56 +1000 Organization: Martyn & Co. Lines: 94 Message-ID: <01bb7af1.b5b0f200$88280fcb@veemob.nettrek.net.au> References: <31EF6EA8.167EB0E7@bioch.ox.ac.uk> NNTP-Posting-Host: veemob.nettrek.net.au X-Newsreader: Microsoft Internet News 4.70.1085 -- any hompages on the NET that have illnesses and/or diseases and/or conditions associated with the LOSS of the sense of touch... OR any hompegaes on the NET that have illnesses and/or diseases and/or conditions that AFFECT the sense of touch ???????? (especially with young children) PLEASE help me! If possible answer this ASAP! (ie b4 Monday) YOUR HELP WOULD BEEEEEEE VERRRRRRRRRRRRRRY APPRECIATED! Venus -- D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh!D'oh !D'oh!;-) "Whoever said TAFE was easy.. bribed their way thru!" said by --> Veenus-Oz <-- << check out my homepage! >> << Venus17 & Veenus-oz's: >> << http://www.geocities.com/TheTropics/3672 >> Come visit the GOLD COAST - Australia's Holiday Playground! SUN , SURF , S*X , SAND !! (and Xcellent niteclubs! and the BEST beer!) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ :-) | "Simon M. Brocklehurst" wrote in article <31EF6EA8.167EB0E7@bioch.ox.ac.uk>... | NAOMI - Message to users/prospective users | __________________________________________________________________________ ___ | | Due to the large number of requests for NAOMI licenses in the last 2 months, | there has been a delay in supplying license keys. | This backlog, however, is now cleared. Because of the heavy influx | of mail/e-mail, however, I think a few people's requests may | have slipped through the net. If you contacted me more than 1 week ago, | and have not yet received a reply I'd be grateful if you'd re-send | your message. | | -------------------------------------------------------------------------- --- | | NAOMI - for studying 3-D structures of proteins. | | NAOMI is available free of charge for academic users. | | NAOMI Version 2.4c is available as of now from the NAOMI Web site at: | | http://www.ocms.ox.ac.uk/~smb/Software/N_details/naomi.html | | or via anonymous ftp | | ftp://nmrz.ocms.ox.ac.uk/pub/smb/naomi | | i.e. at | | nmrz.ocms.ox.ac.uk | | in directory pub/smb/naomi/ | | -------------------------------------------------------------------------- --- | | More information at the commercial Web site at: | | http://www.psynix.co.uk/products/naomi/index.html | | __________________________________________________________________________ ___ | | | | ,_ o Simon M. Brocklehurst, | | / //\, Oxford Centre for Molecular Sciences, Department of Biochemistry, | | \>> | University of Oxford, Oxford, UK. | | \\, E-mail: smb@bioch.ox.ac.uk | WWW: http://www.ocms.ox.ac.uk/~smb/ | |_________________________________________________________________________ ___ | From owner-biophysics@net.bio.net Fri Jul 26 23:00:00 1996 Path: biosci!biosci!not-for-mail From: Iosif Vaisman Newsgroups: bionet.biophysics,bionet.molbio.proteins,bionet.molec-model,bionet.molbio.methds-reagnts,bionet.software,bionet.structural-nmr,bionet.xtallography Subject: Computational Molecular Biology Workshop, October 15-19, 1996 Date: 26 Jul 1996 19:20:59 -0700 Organization: The University of North Carolina at Chapel Hill Lines: 51 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Xref: biosci bionet.biophysics:2176 bionet.molbio.proteins:8396 bionet.molec-model:1079 bionet.molbio.methds-reagnts:47355 bionet.software:16182 bionet.structural-nmr:1403 bionet.xtallography:2764 CAROLINA WORKSHOPS University of North Carolina at Chapel Hill Computational Molecular Biology October 15 - 19, 1996 This course is designed for scientists with limited prior experience in computational molecular biology. The topics to be covered include: biomolecular informatics and databases, protein and nucleic acid sequence analysis and alignment, 3D protein structure analysis and prediction, molecular modeling and dynamic simulations of proteins and nucleic acids, and structure-based drug design. The workshop will consist of the in-depth theoretical lectures and intensive hands-on laboratory sessions. CAROLINA WORKSHOPS are intensive hands-on courses designed to teach cutting edge methods in molecular biology and biotechnology. Four or five courses on different topics in molecular biology and/or biotechnology are offered each year. The courses are designed for novice students as well as for individuals with prior experience. All students benefit from in-depth interaction with instructors. To apply, send a curriculum vitae and a brief letter describing your research interests and their relevance to the Workshop. Applicants should contact the program office as soon as possible. Please indicate your complete mailing address and telephone/fax number. Application Deadline-September 7, 1996. Tuition - $ 1,200.00. Participation is limited to 15 people, please apply early. COURSE DIRECTOR: Alexander Tropsha, Ph.D., University of North Carolina at Chapel Hill INSTRUCTORS: Frank K. Brown (Glaxo-Wellcome) Alexander Tropsha (UNC-Chapel Hill) Wayne Litaker (UNC-Chapel Hill) Iosif I. Vaisman (UNC-Chapel Hill) David C. Richardson (Duke University) For further information or to apply, contact: Dr. Wayne Litaker, Facility Director University of North Carolina at Chapel Hill Program in Molecular Biology & Biotechnology 442 Taylor Hall CB 7100 Chapel Hill, North Carolina 27599-7100 TELEPHONE (919) 966-1730, FAX (919) 966-6821 E-MAIL litaker@med.unc.edu From owner-biophysics@net.bio.net Fri Jul 26 23:00:00 1996 Path: biosci!agate!newsxfer2.itd.umich.edu!portc01.blue.aol.com!news-res.gsl.net!news.gsl.net!news.uoregon.edu!raffles.technet.sg!usenet From: Herman Lim Chih Hsien Newsgroups: bionet.biophysics Subject: Gills and Depth Date: Sat, 27 Jul 1996 21:30:04 +0800 Organization: Victoria JC Lines: 8 Message-ID: <31FA19DC.2186@pacific.net.sg> NNTP-Posting-Host: max84ppp8.pacific.net.sg Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 8bit X-Mailer: Mozilla 2.01KIT (Win95; I) Gills and Depth I’m a student and curious to find out why pond creatures which breathe through gills stay at the deeper parts of the pond instead of surfacing. Please help me. Please reply to my email address. Thank you From owner-biophysics@net.bio.net Fri Jul 26 23:00:00 1996 Path: biosci!PHYS3.C.U-TOKYO.AC.JP!kimoto From: kimoto@PHYS3.C.U-TOKYO.AC.JP Newsgroups: bionet.biophysics Subject: Provider of antiserum against pregnenolone Date: 27 Jul 1996 08:30:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 13 Sender: daemon@net.bio.net Distribution: world Message-ID: <199607271530.AAA16192@phys3.c.u-tokyo.ac.jp> NNTP-Posting-Host: net.bio.net Does anyone know the present address of the Radioassay Systems Laboratories, Inc.? This is the comany, maybe in U.S., providing an antiserum against pregnenolone. I want to employ this for radioimmunoassay of pregnenolone produced by some steroidogenic cells. Thank you for your help. Tetsuya KIMOTO Dept. of Biophysics and Life Sciences Graduate School of Arts and Sciences Univ. of Tokyo at Komaba From owner-biophysics@net.bio.net Fri Jul 26 23:00:00 1996 Path: biosci!VAX.CS.HSCSYR.EDU!Spadaroj From: Spadaroj@VAX.CS.HSCSYR.EDU (Joe Spadaro) Newsgroups: bionet.biophysics Subject: Chicago SPRBM Conference Date: 27 Jul 1996 10:06:18 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 89 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Dear colleagues, This is a program update and invitation for those interested in the control and effects of physical forces (mechanical, electromagnetic, ultrasound, thermal...) on biological systems, cell mechanics, tissue remodeling, growth and repair. 16th ANNUAL SPRBM CONFERENCE SOCIETY FOR PHYSICAL REGULATION IN BIOLOGY AND MEDICINE MIDLAND HOTEL, CHICAGO, ILLINOIS OCTOBER 9-12, 1996 The program is being finalized and printed copies will be available in a week or two. MEANWHILE SEE BELOW AND CONTACT OUR NEW WEB SITE AT: http://http.bsd.uchicago.edu/~btc/sprbm96 Anyone interested in presenting a paper as part of the poster session may still send an abstract to (Deadline Sept 15th, 1996): SPRBM office 9650 Rockville Pike Bethesda, MD 20814 U.S.A. tel: 301-571-0680 Fax: 301-530-7049 E-mail: sprbm@faseb.org or to the Program Chairman: Subrata Saha, Ph.D. Bioengineering Alliance, Clemson University 313 Rhodes Research Center Clemson, SC 29634 U.S.A.. tel: 864-656-7603 Fax: 864-656-4466 E-mail: sally.surver@ces.clemson.edu ***THREE SPECIAL SYMPOSIA THIS YEAR: 1) Influences of Mechanical Forces on Vertebrate Evolution and Design. Invited Speakers: Dr. A.A. Biewener, University of Chicago Dr. R.N. Alexander, Cambridge University 2) Osteoarthrosis: The Role of Physical Factors. Invited Speakers: Dr. A.J. Grodzinsky, M.I.T. Dr. M. Schaffler, Henry Ford Hospital 3) Mechan isms of Cellular Mechanochemical signal Transduction. Invited Speaker: Dr. Barbara Johnson-Wint, University of Illinois ***TOPICAL PAPER SESSIONS THIS YEAR INCLUDE: 1) Electrical and Magnetic Stimulation Effects 2) Lightning Injuries: Mechanisms and Incidences. (Org. by Dr. Mary Ann Cooper) 3) Bone and Ligament Healing All sessions are SINGLE SESSIONS and there is ample time for discussion. ***PRESIDENTIAL GUEST LECTURER: Dr. A Sarmiento MEETING SITE: Midland Hotel (downtown Chicago) 172 West Adams Street Chicago tel: 312-332-1200 Rooms have been blocked at $109 per night (*which includes FULL BREAKFAST) (Additional rooms at lower rates will be available in dormitories at the University of Chicago.) REGISTRATION: NOTE: Until Sept.15 the Registration fees are essentially the same as last year and include: 3 full luncheons, 1 banquet dinner, welcome reception (extra for non-menbers), and all morning and afternoon refreshment snacks and beverages. Members: $295 Non-members: $370 Student member: $125 Student Non-member: $145 CONTACT SPRBM OFFICE BEFORE YOU FORGET (listed above). Joseph A. Spadaro, Ph.D. Associate Professor - Orthopedic Research S.U.N.Y. Health Science Center - Syracuse spadaroj@vax.cs.hscsyr.edu From owner-biophysics@net.bio.net Sat Jul 27 23:00:00 1996 Path: biosci!agate!spool.mu.edu!uwm.edu!news-res.gsl.net!news.gsl.net!hunter.premier.net!uunet!in3.uu.net!excelsior.flash.net!usenet From: keller@flash.net (Steve Keller) Newsgroups: bionet.biophysics,bionet.diagnostics,bionet.general,bionet.neuroscience,bionet.neuroscience.amyloid Subject: HELP PLEASE!!! Date: 28 Jul 1996 04:06:47 GMT Organization: Flash-Net Internet Service Provider, 888-FLASHNET Lines: 236 Message-ID: <4tep0n$6mu@excelsior.flash.net> NNTP-Posting-Host: dpm1-184.flash.net Mime-Version: 1.0 Content-Type: Text/Plain; charset=ISO-8859-1 X-Newsreader: WinVN 0.99.8 (beta 2) Xref: biosci bionet.biophysics:2180 bionet.diagnostics:1005 bionet.general:22869 bionet.neuroscience:15039 bionet.neuroscience.amyloid:532 Hello- This letter is from an individual to their doctor seeking help for their condition. If anyone has knowledge of this sort of problem we'd like to hear from you. Thanks. SK The letter is as follows- Dr. (XXXXX), This letter is a bit longer than usual (2½ pages) -- but it is very important that you read it right away, before you even put on your white coat and start seeing patients. Since we have reached a point in our relationship where all the stops have been pulled out, I am going to write the most brutally honest, direct letter I've ever typed out to you. It is my nature, as you know, to be polite and reserved. But I think it may tell you more about me if I just say whatever comes to my mind. First things first: I want to wean off Clorazepate (I''ve been having a problem with my abdomen hurting constantly for the past several days, even to the point of keeping me awake; Phrenilin aggravates this after a certain point, and I'm not sure but that even Clorazepate does the same). If you would give me one fill (about 30) of the low-powered kind (3.75 Mg.) of Clorazepate, that should be enough. As you know from my letter yesterday, I failed miserably in a job I tried to take on Friday morning. I have to tell you, frankly, that I wept over that on and off all day... because it's happened so many times before. As I start this letter, it is 2:00 A.M. Saturday morning. I have been trying without success, despite Clorazepate and even a little Phrenilin, to get to sleep for the past 2 hours. I cannot rest; these thoughts are churning through my head and I might as well put them down on paper. I recently wrote a letter to a friend of mine, Craig Smith by name, at the City Christian Fellowship church. Craig is an extremely gifted Christian recording artist -- his music is beautiful and touching -- as well as a very kind-hearted person who deeply loves God. He presently occupies the role of pastor of that inter-non-denominational church (to which many Catholics come, because the people are so kind, love God so much, and have such a cheering and positive outlook. They firmly believe in what the Bible says). I will include here a modified excerpt from that letter about how things proceeded for me after a certain date in 1978: ******************************************************************************* ****************** From that point on... well, it's almost impossible to put into words, but I'll try to get something of it across to you. Think of the worst, most terrifying nightmare you ever had in your life -- one in which the entire atmosphere was so deadly that you were literally scared spitless. Then, imagine waking up in the morning... and instead of the dream-fabric fading away as it normally does, the fear remains completely with you; you are just as terrified while awake as you were while having the nightmare. And the fear doesn't go away. All day, all night, all the next day... and on and on and on. Next, think of the most bummed-out, depressive, miserable day or brief period of time you've ever experienced; a day or two that is so completely wretched that you really wish you would be the victim of a drive-by shooting -- and I'm not exaggerating. This terrible depression, just as the awful fear, does not go away either. On and on, day after day, week after week, month after month. You can barely sleep; you totally lose interest in doing anything whatsoever; you can hardly function at all. Finally, imagine waking up each day with a powerful feeling of physical malaise. Your body feels bad, all over, in a way you can't put into words. You ache; worse, you get attacks of bad abdominal pain alternating with frequent horrible headaches. You've had the same type of headaches and abdominal pain earlier in your life -- but they're worse and more frequent now. In a word, you feel absolutely horrible. Life is just absolutely wretched for you. Naturally, you seek the help of Physicians and even Psychiatrists / Psychologists and Counselors. You even end up going to Treatment Programs. The Medical Doctors run some usual tests but can't find anything specifically wrong; the Psychiatrists prescribe Antidepressant medications which not only don't help, they actually make the problem even worse (Elavil, for a start; this causes even worse bad dreams). The Counselors talk to you and the Treatment Programs try to put you through disciplinary regimens. None of these do any good whatsoever. Try very hard to imagine all of these things afflicting you at once. There are no answers; no insights; and absolutely no relief. Period. In the understatement of the century, this is pretty darned bad. If you're expected to stay on your feet and function, it can hardly get any worse than this. Now... not too long after these things have got hold of you, you suddenly end up unexpectedly, one morning when you're supposed to start a new job, in hospital for a kidney stone. I don't know if you've ever had one of these but it is said there are very few things that compare with the pain they produce. You will be writhing all over the place, groaning, throwing up, because the pain is so unbearable. You can't possibly drive; someone else has to take you there. Then, at the hospital, you are given shots of painkillers -- I.E., Demerol, Morphine, etc. And now, something very like an epiphany occurs. After the administration of the drugs, the pain recedes into the background. But that is not the thing that immediately grips your attention. What does make you literally sit up and take notice is the fact that not only does the physical pain float away, but all the fear, the depression, the misery, the anguish, the physical malaise -- all these drift away too, as if they had never existed. For the very first time in months, you feel just like you did before all the horrors started. From here on I will make the story as brief as possible. Ever since that ordeal in the hospital (August 1978), my life has been a running battle with opiate-type pain medicine -- because it was the only thing that gave me relief from the unbelievable wretchedness I suffered. I've seen photos of myself from that time frame; one can tell by looking at my face that something was seriously wrong with me -- I had this awful expression on my face, as if I were suffering from some unbearable internal pain. I looked so bad that it drove some girl I used to go to school with to start praying for me. I've probably driven my personal physician (whom I've known for 10 years) close to stark raving mad with my incessant requests for pain-type medication [NOTE: This is you, Dr. (XXXXX)]. A lot of times the requests were legitimate enough, as I do get very bad migraine-type headaches and bad attacks of abdominal pain -- but more frequently it was just to relieve the awful depression and physical bad feeling. Whenever you've seen me with the familiar bit-into-a-sour-lemon countenance, you can just about bet that I haven't had any medication of that type recently and am really suffering. ******************************************************************************* ****************** There was more to that letter, but that was the part pertinent to this one. Dr. (XXXXX), do you begin to get the picture? Can you imagine waking up just about every blessed day, having an indescribable but very bad feeling over your entire body and/or aching all over? And it being a literal torment from hell just to get up and do anything at all? And being so miserable and depressed that you just do not give a damn about anything? In all honesty, I would not want you to. I would not want Adolf Hitler, that unbelievably evil and cruel leader of Nazi Germany, to go through this. Everyone wakes up not feeling so good occasionally, but this goes very far beyond that. This, to me, is a cruelty beyond belief. You may have already guessed this -- but I will confirm to you that I have had a death wish for at least the past 13 years. Now, do not misunderstand me on this: I have never -- repeat emphatically -- never, entertained the idea of ending my own earthly existence. The same deep, deep belief in God that keeps me from falling apart completely makes me know, of a certainty, that a human being does not have the option to end his or her life. It is God-given, for some reason; however unfathomable that reason may be. That does not mean that I have not still desired to die very greatly. I tell you the truth: I have craved death as a man stranded on a desert craves water. I have hoped I would die in an accident. I have fantasized about dying in a short-term but fatal illness. Any way at all, as long as it would let me out of this horrid existence. Naturally, nothing even remotely like that has ever happened to me. Once, years ago, a pretty knowledgeable pharmacist informed me that some medical studies had shown that certain people had either a deficiency of, or another problem which caused the interference of the action of, the natural morphines (endorphins and enkephalins) in the body. He said that these people suffered exactly the same sort of things that I had been suffering for so long -- they just felt awful all the time for no apparent reason. At the time I rejected this idea; for some reason it repelled me. I suppose it was because it sounded like a death sentence, like something no one could do anything about and would be ultimately fatal many years down the road. But now... I'll be damned if I don't think that may be just exactly what's wrong with me. Look at the facts: Apparently there is a natural check-and-balance of endorphin flow in the body at most times, which makes people feel normally good and able to function. I feel horrible all the time; I ache, feel terrible otherwise, and am depressed. It's like the endorphins simply aren't there at all, or are somehow prevented from doing their job. Many people are on an exercise kick. They push themselves hard; they can run until they hurt and keep on running, and then they get what's known as the Runner's High. This is because after a certain point of muscular strain their bodies release endorphins, which make them feel ever so much better (and they weren't feeling bad to start with). Do you know what happens when I exercise to the point of aching, shaking all over, and of nearly fainting? NOTHING. Nothing, that is, except the most horrible feeling I've ever had in my life -- the feeling that I'm going to die and wish that I could. It does not make any difference how often this cruel regimen is repeated. It can be prolonged endlessly and it does not help to the slightest degree. I feel horrible all the time and cannot function at all. Apparently my body is either not producing the endorphins, or else they are somehow being prohibited from doing their job. Doctor -- I am absolutely desperate. What am I going to do? Truly, I might as well be dead as go on like this -- it is pointless! I cannot function; I cannot work; I cannot live. This is exactly why I have sought pain pills, etc. so much. In addition to relieving the very real and violent headaches and bad abdominal pain I sometimes get (sometimes together -- now there's a real treat!), these medications mimic what my body is apparently lacking. With them, I don't generally feel drunk or high; I just feel like I did before this whole damned thing started so many, many years ago. I can live. I can work. I can function. Of course, pain medication isn't perfect by a longshot; its effect goes downhill after a time and it can have side effects. And, of course, it can produce physical dependency over a period of time -- though I've learned to be pretty careful about that. But it is absolutely the only thing I have ever found that make me feel like a normal human being again -- like I felt before that turning point in 1978. The most practical thing I've ever found, surprisingly, has been Lomotil. Let me explain about Lomotil. It doesn't really behave exactly like normal pain medicine. Lomotil takes a long time to take effect; it is very slow and gentle about coming on. I just become gradually aware of feeling normal again, the only side effect being that it makes my mouth a little dry. Also, though the effect of Lomotil is much less pronounced than that of pain pills, the effect is prolonged. 4 to 6 Lomotil can make me feel well enough to function for a whole day. Doctor, this is truly the bottom line: If I really can't have even so much as Lomotil or Darvon any more (which is a pretty poor painkiller, not even as effective as plain Codeine), isn't there for heaven's sake something that can be done? The only other alternative I see is for me to be certified completely and permanently disabled, in which case I am certain that I will probably end up dying soon from sheer misery. Is there anything, anything at all, that can stimulate the production of endorphins in the body? I've heard of certain little externally applied electronic boxes that produce carefully regulated electrical shocks that stimulate endorphins. I've even read that acupuncture can cause this. I know you don't have all the answers. I know that some things are beyond you. But you are very intelligent and well-informed. If you can think of anything practical, anything at all, please discuss them with me TODAY. This has to be addressed NOW; it cannot wait! Yours Sincerely and Desperately, Anonomous -- ______________________________________________________________________ &&&& & & &&& & & &&& &&&& & & & & & & & & & Steve Keller &&&& &&& &&& & & &&& &&&& keller@flash.net & & & & & & & & & (214)279-1531 &&&&& & & &&& &&& &&& &&& & & http://www.flash.net/~keller ______________________________________________________________________ From owner-biophysics@net.bio.net Sun Jul 28 23:00:00 1996 Path: biosci!PACIFIC.NET.SG!herman1 From: herman1@PACIFIC.NET.SG (Herman Lim Chih Hsien, by way of jungck@beloit.edu (John Jungck)) Newsgroups: bionet.biophysics Subject: Gills and Depth Date: 29 Jul 1996 07:10:34 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 33 Sender: daemon@net.bio.net Distribution: world Message-ID: <9607291410.AA11717@beloit.edu> NNTP-Posting-Host: net.bio.net Dear Herman: Most likely there are at least three reasons: 1st, most ponds get cooler the deeper you go down. Gases (including oxygen) are more soluble in water as the temperature goes down. So it should be easiest to breathe there. 2nd, it is probably safer down there in terms of risk of predation. 3rd, that may be where their food is. Probably lots of additional reasons, but given that you asked biophysicists, I suspect the first explanation is more what you were looking for. Bets wishes, John Gills and Depth Iim a student and curious to find out why pond creatures which breathe through gills stay at the deeper parts of the pond instead of surfacing. Please help me. Please reply to my email address. Thank you From owner-biophysics@net.bio.net Sun Jul 28 23:00:00 1996 Path: biosci!agate!spool.mu.edu!uwm.edu!news.cse.psu.edu!news.eecs.nwu.edu!newsfeed.acns.nwu.edu!news.acns.nwu.edu!news From: "Jody K. Hirsh" Newsgroups: bionet.biophysics Subject: Re: Nerst equilibrium potential and patch clamp configurations ? Date: Mon, 29 Jul 1996 10:34:11 -0400 Organization: Northwestern University Lines: 76 Message-ID: <31FCCBE3.2C38@nwu.edu> References: <4t5a9b$bho@roger.interlynx.net> NNTP-Posting-Host: 165.124.103.61 Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 8bit X-Mailer: Mozilla 2.0 (Win16; I) To: Lars Thomsen Lars Thomsen wrote: > > Dear Reader > > I have a problem which I find very tricky, but first a short > introduction to the problem > > INTRODUCTION > The Nernst equilibrium potential for potassium at physiological > conditions is given by following equation : > > Ek= E0 - (RT/zF)LN([K]inside/[K]outside) > > R= 8.314 J/K·mol > T=absolute temp in Kelvin (=298 K at 25 C) > z= charge of the ion > F=Faradays constant 96500 C/mol > > in many physiological books they state that E0=0 > and they use the reversed ratio [K]out/[K]in and > therefore they get rid of the minus in front of the > equation and ends with : > > Ek= RT/zF ln([K]out/[K]in) , with [K]out = 5 and [K]in = 100 we get > > Ek= 0.0256 * LN(5/100) = -0.077 Volt > > The conditions for this equation is that outside the cell is defined > as zero. > > THE PROBLEM > > We have defined outside as zero and outside is therefore our reference > point. In the recording situation where we have a ground connection to > the amplier made by a Ag/AgCl electrode I assume that that is our > reference point and the potential in the cell to this point is the > cells membrane potential. > > This works very well when we measure in the whole cell or out-side-out > configuration, but what about the in-side-out configuration ? > > In the in-side-out configuration we will have our reference point in > the inside solution and we will have the recording electrode in the > outside solution. If we calculate the Nernst potential for > > [K]in = 5 in respect to the ground, but > [K]in = 100 in respect to the cytoplasmatic side (just as before) > > [K]out = 100 in respect to the recording electrode, but > [K]out = 5 mM in respect to the external side of the cell membrane. > > A) Ek = 0.0256 * LN(out/in) = 0.0256 * LN(100/5) = 0.077 > or > B) Ek= 0.0256 * LN(out/in) = 0.0256 * LN(5/100) = -0.077 > > If B is right, then I can't understand what happened to the reference > point (our ground) and why it doesn't report the inverted potential. > > Best Regards > Lars Thomsen > > Lars Thomsen, MSc. PhD. > 115 South Oval, Hamilton > L8S1R2 Ontario Canada > tlf : +1 905 777 0720 > fax : +1 905 777 0738 > email : lthomsen@interlynx.net > homepage : http://home.interlynx.net/~lthomsen/index.htm > McMaster University, Intestinal Disease Research ProgramThe answer to "B" is correct, because in and out are still the same, tis refers to the sidedness of the membrane, not the bath and electrode solutions. -- Jody K. Hirsh Northwestern University, Chicago, IL. USA jkh141@nwu.edu From owner-biophysics@net.bio.net Sun Jul 28 23:00:00 1996 Path: biosci!ncbi.ncbi.nlm.nih.gov!francis From: francis@ncbi.ncbi.nlm.nih.gov Newsgroups: bionet.biophysics Subject: Entrez version 5.0 Date: 29 Jul 1996 12:55:31 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 32 Sender: daemon@net.bio.net Distribution: world Message-ID: <199607291955.PAA21451@borduas.nlm.nih.gov> NNTP-Posting-Host: net.bio.net NCBI Announces Entrez 5.0 with Cn3D 3D Structure Viewer ======================================================= Entrez now provides a means to visualize molecular structure data. The viewer, Cn3D, is part of Network Entrez client programs and can also be used as a helper application for the Web version of Entrez. A full description of the Cn3D program may be found at the NCBI's Structure Group home page: http://www.ncbi.nlm.nih.gov/Structure Entrez provides an integrated software environment for retrieving and browsing nucleotide and protein sequences, the molecular genetics subset of MEDLINE, and NEW genomes and structures divisions. For more information about Entrez see: http://www3.ncbi.nlm.nih.gov/Entrez or send e-mail to: info@ncbi.nlm.nih.gov --------------------------------------------------------- National Center for Biotechnology Information National Library of Medicine, National Institutes of Health Bethesda, Maryland From owner-biophysics@net.bio.net Sun Jul 28 23:00:00 1996 Path: biosci!biosci!not-for-mail From: Steve Doughty Newsgroups: bionet.molec-model,bionet.biophysics Subject: Molecular Graphics & Modelling Society EC-1 Date: 29 Jul 1996 15:44:32 -0700 Organization: Oxford University Lines: 342 Sender: daemon@net.bio.net Distribution: world Message-ID: <31FCCC1B.167E@bellatrix.pcl.ox.ac.uk> Reply-To: mgmsorg@bellatrix.pcl.ox.ac.uk NNTP-Posting-Host: net.bio.net Xref: biosci bionet.molec-model:1085 bionet.biophysics:2184 FIRST ELECTRONIC MOLECULAR GRAPHICS AND MODELLING SOCIETY CONFERENCE ******************************************************************** see http://bellatrix.pcl.ox.ac.uk/mgms/ The First Electronic Molecular Graphics and Modelling Society Conference (MGMS EC-1) will be held on the Internet (the Net) and World Wide Web (the Web) from Oct 7-18, 1996. The conference is sponsored by Elsevier and the Molecular Graphics and Modelling Society and will be co-organized by Graham Richards, Art Olson, Rod Hubbard and Barry Hardy. MGMS EC-1 will be a fully international event open to all members of the scientific community and will cover a broad range of disciplines related to molecular modelling, graphics and simulation methods and applications. Conference subject areas are: Protein Structure; Membranes and Membrane Proteins; Bioinformatics; Computational Nanotechnology; Protein Folding; Modelling of In Vivo Activity; Knowledge-based Library Design; Surface Science; Host-guest interactions; Carbohydrates; Enzyme Mechanisms; Conformational Analysis; Nucleic Acids; Quantum Chemistry; Car-Parrinello Methods and Applications; Structure-based Design; Visualization; and Perspectives. Each subject area has a section convener who will screen abstracts sent by authors for suitability. Authors can opt to submit a non-permanent presentation like a normal conference poster or a presentation which will be refereed and considered for publication in the Journal of Molecular Graphics. Referees will be appointed by the section conveners. Presentations must be prepared in Hypertext Markup Language (HTML), graphics (GIF,JPEG) and other web-compatible formats (VRML,Java,PDF) so that participants can view the papers via the World Wide Web. Aid and consultation will be provided to participants in the weeks prior to the event to help them with their presentation (Email:mgmsorg@bellatrix.pcl.ox.ac.uk). Further details will be given in the authors' guide accessible via the URL: http://bellatrix.pcl.ox.ac.uk/mgms/ During the conference discussions will take place via the Internet in real-time using a virtual conference centre based on a MOO (multiple-user domain, object oriented) and via Internet-accessible electronic mailing lists. Trial sessions for those not familiar with MOOs will be held before the conference. Before the conference, a timetable for MOO discussion sessions of each section will be posted. Since these realtime discussions are an integral part of the conference, authors will be expected to attend one for their subject; the right is reserved not to referee submissions by authors who do not attend one of these sessions. The Conference will feature a Virtual Trade Center where commercial vendors, software and hardware developers, consultants, and contractors will be able to display their goods and services and provide software demonstrations in return for exhibition fees to support conference activities. Any potential exhibitors should contact Barry Hardy at barry@bellatrix.pcl.ox.ac.uk ******************* DEADLINES AND DATES 1) DO NOW - The MGMS mailing list Conference-related news and announcements will be posted regularly to the MGMS mailing list (http://bellatrix.pcl.ox.ac.uk/hypermail/mgms/). If you wish to subscribe to the MGMS list send the following one line message to majordomo@bellatrix.pcl.ox.ac.uk: subscribe mgms@bellatrix.pcl.ox.ac.uk your_email@address your_name 2) DO NOW - Registration The deadline for registration is Sept 15th 1996. Early registration is strongly encouraged to aid the efficient operation of the conference including the establishment of timely access to the conference. If you intend to participate in MGMS EC-1 please use the registration form accessible via http://bellatrix.pcl.ox.ac.uk/mgms/ which is available for electronic registration. The registration will be used to construct a registrant database for the conference which will generate the conference mailing list and handle assignment of userids and passwords. In addition it is necessary to pay for registration via ordinary means: The conference fee will be 35 pounds sterling (50 US dollars) with a special rate for students of 20 pounds sterling (30 US dollars). A copy of a suitable student identification or a letter from the supervisor will be required to be charged at the lower rate. Registration payments can be accepted by credit card, direct bank transfer, cheque or bank draft. Regardless of method of payment we ask you to supply accompanying correspondence with your complete name, address, fax and phone number, and email address which should be mailed directly to: Dr. Barry Hardy, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK Payment Instructions: a) Credit Card We can currently accept Visa, Mastercard, Switch or JCB. We cannot yet accept American Express as our application with them has still to be processed. Please send your credit card type, number and expiration date via regular mail to: Dr. Barry Hardy, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK b) Bank Transfer Your payment can be made in sterling by direct bank transfer into the folowing account: Account Number: 20-6518 50772712 Account Name: Greenlea Communications Bank: Barclays Bank, Oxford City Centre Branch, P.O. Box 333, Oxford, OX1 3HS, UK --Please ensure your full name is listed with the transfer details. --You are responsible for any bank charges associated with the transfer from your bank. --Please notify us directly of your transfer payment. 3) Cheque/Bank Draft Cheques or bank orders (in pounds or dollars) should be made out to Greenlea Communications and mailed to: Dr. Barry Hardy, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK Acknowledgement of Registration and Payment: When you first register at the conference site you should receive an acknowledgement email with a password and userid. After receipt of your registration fee you will receive a further acknowledgement and your userid and password will be validated to allow access to the conference site (when it opens). (Note: Registration payments received during the period July 23- August 14 will not be immediately processed and acknowledged. They will be processed as soon after August 14 as possible.) Academic registrants from economically-disadvantaged countries can write to Barry Hardy requesting an exemption to the registration fee. Exemptions will be made on a discretionary basis taking into account the reasons given for the request and will be dependent on suitable funds being available. We will consider economically disadvantaged countries to include those of Eastern Europe, Africa, Central and South America, Indian sub-continent, etc. 3) DEADLINE for receipt of ABSTRACT. The deadline for receipt of presentation abstracts is August 1. Email your abstract directly to the appropriate section convener listed below. Fuller details of the scope of each section will be given in the authors' guide accessible via http://bellatrix.pcl.ox.ac.uk/mgms/ Your abstract should be no longer than 300 words. And remember to state which category of presentation (non-permanent poster or refereed paper) you wish. If you are unsure as to which section your abstract is suitable for, please email a possible section convener or Barry Hardy (barry@bellatrix.pcl.ox.ac.uk). Section conveners do have the discretion to reject abstracts, ask for revisions to an abstract or to send the abstract to the convener of a more suitable section. 4) DEADLINE for receipt of PRESENTATION The deadline for receipt of papers and posters is Sept 15th. You must deposit your text and graphics files at the conference ftp site for presentation at the conference. Ftp instructions will be provided at the conference site. Hard copies of final refereed papers following the format of the Journal of Molecular Graphics should be sent by Dec 1 to: Graham Richards, Journal of Molecular Graphics, Physical & Theoretical Chemistry Lab, Sth Parks Rd, University of Oxford, Oxford, OX1 3QZ, UK. Journal guidelines are posted at http://bellatrix.pcl.ox.ac.uk/mgms/ Although there is no limit to the graphics authors choose to display in their conference presentation, the editor reserves the right to limit the number of free colour figures in each printed journal article. 5) Refereeing Period The refereeing period will commence upon completion of the conference. If you have a presentation at MGMS EC-1 you may be requested to contribute a refereeing evaluation on another conference presentation. Referee reports will be due November 15. ******************* SECTIONS AND SECTION CONVENERS (Please email section conveners with questions related to your particular section and presentation. Details on the sections are accessible via http://bellatrix.pcl.ox.ac.uk/mgms/) Any general emails (such as registration queries, maillist queries, HTML queries, password queries, timetable queries, general technical advice on browsers and graphics, MOO queries, etc.) should be sent to: mgmsorg@bellatrix.pcl.ox.ac.uk 1. Protein Structure Rod Hubbard University of York, UK Email:rod@yorvic.york.ac.uk 2. Nucleic Acids David Beveridge and Dennis Sprous Wesleyan University, USA Email:bever@rose.chem.wesleyan.edu,dsprous@rose.chem.wesleyan.edu 3. Membranes and Membrane Proteins Alan Robinson University of Oxford, UK Email:alan@bellatrix.pcl.ox.ac.uk and Terry Stouch Bristol-Myers Squibb, USA Email:stouch@dino.bms.com 4. Bioinformatics Steve Gardner Oxford Molecular, UK Email:sgardner@oxmol.co.uk 5. Computational Nanotechnology Al Globus NASA-Ames, USA Email:globus@nas.nasa.gov 6. Protein Folding Jeffrey Skolnick Scripps Institute, USA Email:skolnick@scripps.edu 7. Modelling of In Vivo Activity Edward Hodgkin Wyeth-Ayerst Research, USA Email:hodgkie@war.wyeth.com 8. Knowledge-based Library Design Mike Hann GlaxoWellcome, UK Email:mmh1203@ggr.co.uk 9. Surface Science Donald Brenner North Carolina State, USA Email:dwb@ripley.mte.ncsu.edu 10. Host-Guest interactions Jon Essex Southampton University, UK Email:J.W.Essex@soton.ac.uk 11. Carbohydrates and Protein-Carbohydrate Interactions Anne Imberty CNRS, France Email:imberty@nantes.inra.fr 12. Enzyme Mechanisms Guy Grant University College Dublin, Ireland Email:ggrant@macollamh.ucd.ie 13. Stochastic Methods for Conformational Sampling Robert Topper The Cooper Union, USA Email:topper@cooper.edu 14. Quantum Chemistry Tim Clark University of Erlangen, Germany Email:clark@organik.uni-erlangen.de 15. Structure-based Design David Winkler CSIRO, Australia Email:D.Winkler@chem.csiro.au 16. Car-Parrinello Methods and Applications Michele Parrinello Max-Planck Institute, Germany Email:prr@prr.mpi-stuttgart.mpg.de 17. Visualization Art Olson Scripps Institute, USA Email:olson@scripps.edu 18. Perspectives in Molecular Modelling Graham Richards University of Oxford, UK Email:gr@vax.ox.ac.uk -- ------------------------------------------------------------------ // || \\ // Stephen Doughty || "The best and most \\ // Physical & Theoretical Chemistry Lab.||beautiful things in \\ // Oxford University, ||this world cannot be \\ // South Parks Road, OXFORD, OX1 3QZ, UK||seen or even touched.\\ // ||They must be felt \\ // Tel: +44 1865 275475 ||with the heart." \\ //--------------------------------------------------------------\\ // Email : steve@bellatrix.pcl.ox.ac.uk \\ // WWW : http://bellatrix.pcl.ox.ac.uk/people/steve/ \\ ------------------------------------------------------------------ From owner-biophysics@net.bio.net Mon Jul 29 23:00:00 1996 Path: biosci!agate!news.Stanford.EDU!usenet From: Michael Lee Newsgroups: bionet.biophysics Subject: Ussing Chambers Date: Sun, 28 Jul 1996 17:36:09 -0700 Organization: Stanford University Lines: 4 Message-ID: <31FC0779.122C@leland.stanford.edu> NNTP-Posting-Host: piper.stanford.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 2.0 (Win16; I) Anyone know of any good texts of Ussing chambers for transepithelial ion transport, especially in terms of data interpretation? - ml From owner-biophysics@net.bio.net Mon Jul 29 23:00:00 1996 Path: biosci!DUKE.POLY.EDU!ntooney From: ntooney@DUKE.POLY.EDU ("Nancy M. Tooney") Newsgroups: bionet.biophysics Subject: Golden Oldie available Date: 30 Jul 1996 07:05:37 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 9 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Dear Biophysics list, Anyone out there with an interst in old Model E sultracentrifuges? We are about to consign ours to the scrap heap. If anyone would like to cannibilize it for parts, please rsvp asap. Nancy Tooney From owner-biophysics@net.bio.net Tue Jul 30 23:00:00 1996 Path: biosci!rutgers!uwm.edu!cs.utexas.edu!swrinde!newsfeed.internetmci.com!info.ucla.edu!unixg.ubc.ca!van-bc!n1van.istar!van.istar!west.istar!ott.istar!istar.net!n3ott.istar!infoshare!passport.ca!news2.insinc.net!roger.interlynx.net!news From: Lars Thomsen Newsgroups: bionet.biophysics Subject: Reversal potential Date: Wed, 31 Jul 1996 12:09:03 -0400 Organization: McMaster University, Intestinal Research Disease Programme Lines: 12 Message-ID: <31FF851F.68E9@interlynx.net> Reply-To: lthomsen@interlynx.net NNTP-Posting-Host: ppp23-max2.interlynx.net Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.0b5a (Win95; I) DEFINITION OF REVERSAL POTENTIAL The reversal potential is defined as the maximum overall effort that you can present at that time where the derivative of the function expressing the sum of your boss and wifes expectations comes out negative. -- Lars Thomsen, MSc. PhD. 115 South Oval, Hamilton, L8S1R2 Ontario, Canada tel +1 905 777 0720 fax +1 905 777 0738 email : lthomsen@interlynx.net homepage : http://home.interlynx.net/~lthomsen/index.htm From owner-biophysics@net.bio.net Wed Jul 31 23:00:00 1996 Path: biosci!LEX.LCCC.EDU!rcb1 From: rcb1@LEX.LCCC.EDU (Ron Blue) Newsgroups: bionet.biophysics Subject: Re: Reversal potential Date: 1 Aug 1996 09:14:37 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 11 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <31FF851F.68E9@interlynx.net> NNTP-Posting-Host: net.bio.net On Wed, 31 Jul 1996, Lars Thomsen wrote: > DEFINITION OF REVERSAL POTENTIAL > The reversal potential is defined as the maximum overall effort that > you can present at that time where the derivative of the function > expressing the sum of your boss and wifes expectations comes out > negative. A very important concept to say the least. I would define it as the effect one experience after running on a treadmill and quickly getting off and looking at the wall and see the wall going forward. Ron Blue From owner-biophysics@net.bio.net Wed Jul 31 23:00:00 1996 Path: biosci!agate!howland.reston.ans.net!vixen.cso.uiuc.edu!newsfeed.internetmci.com!in3.uu.net!ott.istar!istar.net!tor.istar!east.istar!news.nstn.ca!coranto.ucs.mun.ca!plato.ucs.mun.ca!wmfry From: Mark Fry Newsgroups: bionet.biophysics Subject: loose patch clamp Date: Thu, 1 Aug 1996 11:19:49 -0230 Organization: Memorial University of Newfoundland Lines: 28 Message-ID: NNTP-Posting-Host: plato.ucs.mun.ca Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Sender: wmfry@plato.ucs.mun.ca Hi. I have an LPC-3 loose patch clamp amplifier from medical systems corp (/List-electronics) with a burned out potentiometer. The bum pot is the motorized one that controls leakage compensation, and I can't find another anywhere. It is a 10k, 10 turn pot, but it has no part number. I think it may have been manufactured by Prazisions Elektronik / H. Knuppel of West Berlin. Medical Systems Corp of Greenvale NY can't help me at all, I guess the amp is too old. Is there anybody out there who knows where i can find a suitable replacement part. Maybe somebody has cannibalized an old LPC-3 for parts and has not used this one. Or even still, maybe somebody knows some neat tricks i can use to modifey this one. thanks for any help. Mark Fry ribit @..@ 4th floor BMS Fac of Med. \ (----) Memorial University of NFLD ( >**< ) A1B 3V6 ^^^""""^^^ wmfry@plato.ucs.mun.ca (Xenopus) From owner-biophysics@net.bio.net Wed Jul 31 23:00:00 1996 Path: biosci!INTERLYNX.NET!lthomsen From: lthomsen@INTERLYNX.NET ("Lars Thomsen") Newsgroups: bionet.biophysics Subject: Re: Reversal potential Date: 1 Aug 1996 13:07:16 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 9 Sender: daemon@net.bio.net Distribution: world Message-ID: <199608011844.OAA12265@boris.interlynx.net> Reply-To: lthomsen@interlynx.net NNTP-Posting-Host: net.bio.net Sorry about my joke - I couldn't help it. But the effect you describe is that really correlated to the reversal potential and how ? Lars Thomsen, MS PhD 115 South Oval Hamilton, L8S1R2 Ontario Canada Tlf +1 905 777 0720 Fax +1 905 777 0738 Email lthomsen@interlynx.net http://home.interlynx.net/~lthomsen/index.htm