From owner-biophysics@net.bio.net Mon Aug 03 23:00:00 1998 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!newsfeed.internetmci.com!202.44.200.8!news.inet.co.th!news.nectec.or.th!malakor.kku.ac.th From: Jhon Smith Newsgroups: bionet.biophysics Subject: Test Date: Tue, 04 Aug 1998 21:18:26 PDT Organization: Khon Kaen University, Khon Kaen, Thailand Lines: 2 Message-ID: <04081998211826test@test.com> NNTP-Posting-Host: 194.176.43.117 Test From owner-biophysics@net.bio.net Mon Aug 03 23:00:00 1998 Path: biosci!news.stanford.edu!logbridge.uoregon.edu!news.idt.net!newsfeed.internetmci.com!202.44.200.8!news.inet.co.th!news.nectec.or.th!malakor.kku.ac.th From: Jhon Smith Newsgroups: bionet.biophysics Subject: Counter Date: Tue, 04 Aug 1998 21:33:45 PDT Organization: Khon Kaen University, Khon Kaen, Thailand Lines: 2 Message-ID: <04081998213345test@test.com> NNTP-Posting-Host: 194.176.43.117 You may add link to our Site From owner-biophysics@net.bio.net Wed Aug 05 23:00:00 1998 Path: biosci!news.stanford.edu!Cabal.CESspool!bofh.vszbr.cz!newscore.univie.ac.at!news-raspail.gip.net!news-peer.gip.net!news.gsl.net!gip.net!newsfeed.internetmci.com!207.217.77.43!newsfeed1.earthlink.net!nntp.earthlink.net!not-for-mail From: specpress@earthlink.net (SCIENCE-WEEK Editors) Newsgroups: bionet.neuroscience,bionet.biophysics,bionet.cellbiol,bionet.general,sci.misc Subject: SCIENCE-WEEK Focus Reports - Available Free Date: Thu, 06 Aug 1998 02:12:23 GMT Organization: Science-Week Lines: 24 Message-ID: <6qb3i1$pn1$2@holly.prod.itd.earthlink.net> Reply-To: specpress@earthlink.net NNTP-Posting-Host: 1cust251.tnt12.chi5.da.uu.net X-Newsreader: Forte Free Agent 1.0.82 Xref: biosci bionet.neuroscience:24065 bionet.biophysics:4319 bionet.cellbiol:9935 bionet.general:30531 SCIENCE-WEEK Focus Reports are explicating texts and summary groups ranging from 10K to 30K bytes in length, and available at no charge. The following reports are now posted at : Biological Cell Membranes (1) The Death of Stars Weak Bonds in Chemistry and Biology Biological Cell Membranes (2) Atomic and Molecular Spectroscopy The Neuron The Birth of Galaxies and Stars Viruses Origin of Life Cosmology: Dark Matter Molecular Biology: Protein Folding Astrophysics: Gamma Ray Bursts The Editors SCIENCE-WEEK editors@scienceweek.com http://scienceweek.com From owner-biophysics@net.bio.net Wed Aug 05 23:00:00 1998 Path: biosci!news.stanford.edu!logbridge.uoregon.edu!newspeer.monmouth.com!oleane!jussieu.fr!univ-lille1.fr!ciril.fr!cnusc.fr!SP2N3.U-3MRS.FR!news From: Eric Blanc Newsgroups: bionet.biophysics Subject: Re: Counter Date: Thu, 06 Aug 1998 10:38:25 -0700 Organization: Centre de Calcul de Saint Jerome Lines: 23 Message-ID: <35C9EA11.FF6@afmb.cnrs-mrs.fr> References: <04081998213345test@test.com> NNTP-Posting-Host: afmb97.cnrs-mrs.fr Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.01SGoldC-SGI (X11; I; IRIX 6.3 IP32) Jhon Smith wrote: > > You may add link to our Site \ What ????? -- ,-~~-.___. / | ' \ ( ) 0 \_/-, ,----' ==== // / \-'~; /~~~(O) / __/~| / | =( _____| (_________| _______ _________ / __/ _ \/ _/ ___/ / _// , _// // /__ /___/_/|_/___/\___/ From owner-biophysics@net.bio.net Thu Aug 06 23:00:00 1998 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!news.bbnplanet.com!newsfeed.corridex.com!howland.erols.net!nntprelay.mathworks.com!newsfeed1.earthlink.net!nntp.earthlink.net!not-for-mail From: specpress@earthlink.net (SCIENCE-WEEK Editors) Newsgroups: bionet.neuroscience,bionet.biophysics,bionet.cellbiol,bionet.general,sci.misc Subject: UPDATE: SCIENCE-WEEK Focus Reports - Available Free Date: Fri, 07 Aug 1998 15:00:30 GMT Organization: Science-Week Lines: 27 Message-ID: <6qf4u8$gt4$2@fir.prod.itd.earthlink.net> Reply-To: specpress@earthlink.net NNTP-Posting-Host: 1cust237.tnt11.chi5.da.uu.net X-Newsreader: Forte Free Agent 1.0.82 Xref: biosci bionet.neuroscience:24077 bionet.biophysics:4321 bionet.cellbiol:9945 bionet.general:30536 SCIENCE-WEEK Focus Reports are explicating texts and summary groups ranging from 10K to 30K bytes in length, and available at no charge. The following reports are now posted at : Quantum Mechanics Earth Science Microbial Drug Resistance Biological Cell Membranes (1) The Death of Stars Weak Bonds in Chemistry and Biology Biological Cell Membranes (2) Atomic and Molecular Spectroscopy The Neuron The Birth of Galaxies and Stars Viruses Origin of Life Cosmology: Dark Matter Molecular Biology: Protein Folding Astrophysics: Gamma Ray Bursts The Editors SCIENCE-WEEK editors@scienceweek.com http://scienceweek.com From owner-biophysics@net.bio.net Thu Aug 06 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.concentric.net!newshub.northeast.verio.net!newsfeed.ecrc.net!news-fra1.dfn.de!news-ber1.dfn.de!news-ham1.dfn.de!news-han1.dfn.de!news.gwdg.de!not-for-mail From: Arne Mueller Newsgroups: bionet.biophysics Subject: Surface Plasmon Resonance Date: Fri, 07 Aug 1998 19:35:25 +0000 Organization: GWDG, Goettingen Lines: 23 Message-ID: <35CB56FD.CAEE4D49@gwdg.de> NNTP-Posting-Host: roko28.stud.uni-goettingen.de Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.05 [en] (X11; I; Linux 2.0.33 i586) Hi All, Can anyone here explain me in short words the principles of Surface Plasmon Resonance? I'm, a biologist working with proteins and DNA on a BIAcore, and I've to admit I haven't understood the principles of the phenomena. So maybe you can give me a quick introduction - only to know what happens in this black box machine ... ;-) thanks very much for help, Arne -- Arne Mueller Institut fuer Mikrobiologie und Genetik Abt. Molekulare Genetik und Praeparative Molekularbiologie Universitaet Goettingen Grisebachstr. 8 37077 Goettingen Germany phone: +49-551-399654 | fax : +49-551-393805 email: amuelle3@gwdg.de | http://www.roko.goe.net/~amuell4/ From owner-biophysics@net.bio.net Sun Aug 09 23:00:00 1998 Path: biosci!rutgers!rockyd.rockefeller.edu!news-nysernet-5.sprintlink.net!news-dc-2.sprintlink.net!news-east.sprintlink.net!news-peer.sprintlink.net!news.sprintlink.net!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!news-peer.gip.net!news.gsl.net!gip.net!portc01.blue.aol.com!audrey01.news.aol.com!not-for-mail From: capaliwoda@aol.com (CAPaliwoda) Newsgroups: bionet.biophysics Subject: HIGH-TECH CRIME SYNDICATE IN OHIO Lines: 218 Message-ID: <1998081017595000.NAA00205@ladder01.news.aol.com> NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com Date: 10 Aug 1998 17:59:50 GMT Organization: AOL http://www.aol.com I wish to report a bizarre crime situation in the Maple Heights, Ohio area (a suburb of Cleveland, USA) using a form of radiation-based mind control. A criminal gang is entrapping and torturing victims with radiation bombardment (deliberately trying to produce brain injuries), electronic rape, transmission of rabid screech "voices" (sound simulation being possible), round-the-clock force-fed verbal communications, and drug effects (transferred from drug users who are apparently on amphetamines, coke, etc.--at intentionally uncomfortable levels in order to stress victims into nervous breakdowns). Victims are kept debilitated with chronic radiation poisoning which is at times similar in potency to nerve- (or minimally tear-) gas in terms of being a hazardous biological agent, except that the effects are more directable to the specific target. The levels are periodically upped to that point whenever the predators deem it necessary to keep their prey in thrall, or to achieve a desired end. Although, torture could be described as intermittent, communication is continuous. This is in effect electronic telepathy--being used for nothing but deleterious purposes, however (for the implementation of torture). The signal can be transmitted to victims from incredible distances with accuracy, it is impossible to evade, and there is a large army of persons engaged in the stalking (7 days, 24 hours--with unbelievable tenacity). There is probable usage of satellite tracking, augmented by ground-based weapons, making escape difficult. (Surmising the means is theoretical, based on prolonged experience.) I have been followed without relent for 25 years now, around the clock, by stalkers who never stop preying on their victim. They are sadists who do all in their power to inflict suffering on victims, in a way that is senseless--constantly engaging in psychological and physical abuse. They latch on to a victim and never thereafter permit prey to experience full consciousness, denying freedom of thought and basic human rights. Packs of thugs gang up on helpless individuals with laser weapons and try to administer brain damage, to knock the victim's brains out, so to speak. An army of them surround the victim from hidden locations, from time to time generating shrieking effects and hyped-up nervous states while so doing as a means of creating mental distress. I reported the abuses in the 1970's. There was a phony Congressional investigation, a little bit of press flurry about illegal CIA activity which never divulged the main facts--camouflaging the mind control as a drug operation instead of revealing the technological bases of the radiation-based mind control--then a smokescreen put up through U.S. news media, which seem to have become pawns of a de facto dictatorship. The public went back into a quiescent sleep while the perpetrators bore down more cruelly on helpless victims. Some of the transmissions are suspected of being via satellite. In fact, the evidence to this effect is for me overwhelming. The roof of a building (i.e. your house) can be targeted, and there is very little scattering to the outside, creating the apparent impression that nothing is happening (outside). Meanwhile a humongous pulsating signal is being generated inside, creating standing waves through directed-beam transmissions. However, the victim need not be stationary to receive. The signal goes for miles. Being stationary makes it easier to deliver pain and to concentrate harassment, though. The so-called Star Wars program could be a dangerous offensive weapons program which is a tool of a virtual dictatorship. People who know too much and are willing to talk are stalked with the mind control by torturers until they suffer ruin--suicides, destitution, confinement to mental institutions, diagnoses of fake schizophrenia, which is degrading character assassination--even subjected to illegal psychosurgery after being driven into provoked rages with torture from which they could not escape. The U.S. press appears to have complicity in maintaining secrecy--conferring absolute power on the vicious clique monopolizing this technology. No defenses are ever developed for detection by an unwitting population which is never informed of any capabilities of it. The ability to stalk press people with the mind control is part of the reason for the successful secrecy, but there is also a certain amount of corruption on the part of the establishment, which is kept comfortable as long as it plays along. The technocracy is careful to (overtly) victimize only the weakest and most helpless of prey for target practice, to cover its tracks. I know I am surrounded by an army of these persons, with beams coming from multiple directions. I have been anything but silent to local police, yet I have never seen any discipline of the criminals. Some of the predators will pose as benevolent (as therapists, well-wishers, religionists, etc.) until they think they are not being observed, and then they will do a 180 degree turn and start their extortion and terrorization. There has been no halt to their operations in 25 years. I have registered complaint after complaint after complaint with the local police department. The one person I have been able to pinpoint as being somehow (maybe indirectly--through some kind of guilt by association) connected with the technology is an improbable type--a Mr. John Wavrzacz at 14101 Rockside Rd., Maple Heights, Ohio. Evidence was an uncanny ability to know about events he had no means of being privy to other than some kind of clairvoyance. The son of neighbor Carol Tipton (formerly Skocdopole), 5337 E. 141 St., also needs investigation. Although he appears outwardly decent, Al Kovach, the person who purchased my home on E. 141 and from whom I rent, is also a mystery figure. I can't afford to leave any stones unturned. Another fact: In the past I distributed a report with a Feb. 7, 1976 Cleveland Plain Dealer newsclipping attached entitled "Soviets said to spy with perilous rays". There was a lot of ensuing reference in the media to CIA mind control about that time. After I let out Wavrzacz's name in 1996, some terrorists hit me with an incredible radiation blast akin in its effects to tear gas. This stuff causes respiratory passages to swell until near-suffocation results. Without antihistamines, the ability to breath is threatened. In their communications perpetrators make reference to some kind of "gang" and "family" membership. There is never a police bust of criminal perpetrators in this area. Activity is occurring in the E. 141 St.-Granger Rd. section of Maple Heights, Ohio. At least that is the target area (overhead satellite technology augmented by ground-based weapons--this is just theory, it is difficult for me to ascertain the exact means). No complaints to any authority are ever to any avail. There are upsurges in torture activity correlating with breaks in the academic calendar--Spring break being the worst time of the year. This leads me to suspect participation of academics in the crimes. Local colleges--CWRU and CSU--are suspect. Possibly students lured into collaboration by criminal professors, or some such scenario. How American students could be lured into supporting anything so flagrantly antidemocratic I couldn't begin to guess. I am also considering local hospitals as possibly being sites of activity. There are two Veterans hospitals in the area--in Brecksville and Cleveland, plus a branch of NASA. I was in Marymount Hospital in Garfield Heights, Ohio a couple of times. It is the only hospital I have ever dealt with directly--once having undergone surgery. Although anyone who had experienced this phenomenon would think some sort of implant for tracking and reception necessary, a CAT scan and x-rays of my brain back in 1981 by Radiologic Medical Imaging Associates in Mayfield Hts., Ohio (referral from a Dr. Grant Heller in Beachwood,Ohio) did not turn any up, according to radiologists who reviewed them. There are indications from his behavior that my brother Bill was also a previous victim. He is today very ill, displaying symptoms of long-term abuse. The American public can never acquire defenses, regulation, pertinent laws, or restriction so long as the secrets are kept. I need help in tracking to source. Victims undergoing the most heart-rending violations are simply brushed off as lunatics, ignored, scoffed at--and it is an affront to human decency and dignity. The reason secrecy has been maintained this long (over twenty documented years) is the promotion of a vicious reign of terror against any resistance or dissent. Anyone who knows anything is stalked and tortured until they crumble. The clique in power are very cocky and obnoxious overlords, in the process of transforming the democracy into a farce. The group which has victimized me is little more than a ring of psychotic deviates who molest innocents for sadistic kicks--deriving some kind of insane satisfaction from intimidating helpless prey for spite. They have no consciences or internal limits, and brag about their amorality. I believe they have been picking up women (and boys) for sexual reasons, afterwards driving them insane. They juice up on dope while they hold their prey captive. While they attempt to damage the victims' brains, they spew Nazi philosophy at them. I sometimes wonder if secret police (military) support exists--a suspicion derived from the fact that activities are never stopped. These persons, who are terrorists, never face arrest, intimidating me without end. In at least one area of the country (New York City) I have evidence of coordination with mental health authorities to entrap victims into insane asylums. This is of course after deliberately driving them crazy. What I have depicted is a brutal denial of the rights to life, liberty, the pursuit of happiness, and security in their homes which are supposedly guaranteed to law-abiding Americans. The thirteenth amendment prohibition against slavery is also violated. If the technology were in the right hands (instead of the very wrong ones who hold it now), there might be a questionable need to expose it. However, victims like myself have been subjected to cruel and unusual punishments. Like 25 years of constant telemetric tracking combined with efforts to induce psychological breakdown and persistent torture. Persons like my clueless brother Bill subjected to what looks like illegal experimentation with extremely destructive effects--virtual loss of life which is the result of prolonged torture (and possibly psychosurgery). Naivete and weakness make the target all the more tempting, apparently. Some of the perpetrators want to know if the human being can be completely robotized with psychological (and physical) breakdown methods, and they never know when to stop. Their big dream is to produce a mindless golem. This is not expanding human potential in a positive way. The technology is dangerous, yes. But there is no excuse for the kind of abuse which has gone on. People's lives have been destroyed. The most innocent kinds of people too. The need for secrecy is not sufficient justification. Unbefitting Civilized Man, if such could be said to exist. signed: capaliwoda@megsinet.net Maple Heights, Ohio (suburb of Cleveland) From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!howland.erols.net!europa.clark.net!192.174.65.44!newscore.univie.ac.at!newsfeed03.univie.ac.at!03-newsfeed.univie.ac.at!fstgal00.tu-graz.ac.at!not-for-mail From: "Josef Riegebauer" Newsgroups: bionet.biophysics Subject: Energy of a thought Date: 11 Aug 1998 06:32:03 GMT Organization: Graz University of Technology, Austria Lines: 7 Message-ID: <01bdc4fa$69daffb0$5407f79d@pmed073> NNTP-Posting-Host: avlgate.avl.co.at X-Newsreader: Microsoft Internet News 4.70.1161 Has anybody an idea of how much energy or power consumption a normal human thought produces or needs ? Any literature or book reference on that topic ? Regards, Josef From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!sunqbc.risq.qc.ca!carnaval.risq.qc.ca!not-for-mail Message-ID: <35D06A81.70751E86@PLGCN.UMontreal.CA> From: Stefan Seefeld X-Mailer: Mozilla 4.03 [en] (X11; I; Linux 2.0.32 i686) MIME-Version: 1.0 Newsgroups: bionet.biophysics Subject: Re: Products of ions and all that... References: <35D055BD.A3F9B49B@pitt.edu> Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Lines: 57 Date: Tue, 11 Aug 1998 15:57:36 GMT NNTP-Posting-Host: 132.204.70.88 NNTP-Posting-Date: Tue, 11 Aug 1998 11:57:36 EDT Terry Morris wrote: > > Ok you clever people, > > You know that equilibrium equation we all were taught in chemistry class: The product of the > PRODUCTS divided by the product of the REACTANTS is a constant. This has bugged me for years and > I'm finally comming out of the closet about it (Don't you just hate it when formulas are simply > given. I've been told that the equilibria equation was determined empirically, end of story. > Nah!). How can this result be interpreted in terms of what is going on at the molecular level; > why do we multiply the species concentrations together? Beacuse, in mathematical terms, when you > multiply pairs of numbers together from say a range of integers between 1 and ten, the greatest > value occurs at 5 x 5 = 25. So, what this formula is saying is that the value of the numerator or > denominator is at maximum went those species are in equal quantities. What does this model in > terms of molecule pairs interacting? > > I have some vague notions of my own about the the maxium proportion of collisions between species > pairs taking place when they are in equal quantity. But I have never seen these questions > addressed in any text, and I dont have the math or physics background to begin to work it out > myself. To the second question first: you want to multiply two numbers x, y, whose sum is 10. So you have x + y = 10; x * y = P; and you are looking for the maximum P. As you will know, you can get max/min values of a function in setting the derivative to zero: P' = d/dx (10*x - x^2) = 10 - 2*x So you find the maximum at x = 5. Why this is so is simply a question of symmetry. The first question why the mass action law is as it is has absolutely nothing to do with that since the numbers of reactants don't vary independantly. But with a bit of thought you will realize that the probability for a collision is proportional to each of the reactants concentration. So since in equilibrium you have equal reaction rates forth and back meaning that it is equally probable for a reactive collision to occure in either direction, this naturally leads to the conclusion that the ratio of the products of the reactants on both sides is constant (the constant itself depends on other system parameters) Regards, Stefan _______________________________________________________ Stefan Seefeld Departement de Physique Universite de Montreal email: seefelds@plgcn.umontreal.ca _______________________________________________________ ...ich hab' noch einen Koffer in Berlin... From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!pravda.ucr.edu!awabi.library.ucla.edu!208.134.241.18!newsfeed.internetmci.com!141.211.144.13!newsxfer3.itd.umich.edu!news.eecs.umich.edu!news.bu.edu!not-for-mail From: luxiang Newsgroups: sci.bio.technology,bionet.neuroscience,bionet.general,bionet.biophysics,bionet.diagnosis,sci.engr.biomed Subject: Fast-scan Voltammetry Date: Tue, 11 Aug 1998 19:29:20 -0400 Organization: Boston University Lines: 8 Message-ID: <35D0D3D0.9950AE0@bu.edu> NNTP-Posting-Host: pseudemys.bu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.04 [en] (Win95; I) Xref: biosci bionet.neuroscience:24133 bionet.general:30559 bionet.biophysics:4330 Hi There I want to know something about 'Fast-scan Voltammetry' for in vivo detection of Dopamine, serotonin. can anybody help to offer any resources on this tech? Thanks a lot! From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!pravda.ucr.edu!awabi.library.ucla.edu!208.134.241.18!newsfeed.internetmci.com!141.211.144.13!newsxfer3.itd.umich.edu!news.eecs.umich.edu!news.bu.edu!not-for-mail From: luxiang Newsgroups: sci.bio.technology,bionet.neuroscience,bionet.general,bionet.biophysics,bionet.diagnosis,sci.engr.biomed Subject: Fast-scan Voltammetry Date: Tue, 11 Aug 1998 19:26:20 -0400 Organization: Boston University Lines: 8 Message-ID: <35D0D31C.7E4BB592@bu.edu> NNTP-Posting-Host: pseudemys.bu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.04 [en] (Win95; I) Xref: biosci bionet.neuroscience:24132 bionet.general:30558 bionet.biophysics:4329 Hi There CI want to know something about 'Fast-scan Voltammetryan' for the in vivo detection of Dopamine, serotonin. can anybody help to offer any resources on this tech? Thanks a lot! From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!UCONNVM.UCONN.EDU!rhodes From: rhodes@UCONNVM.UCONN.EDU ("David G. Rhodes") Newsgroups: bionet.biophysics Subject: [Fwd: Postdoc Position Available] Date: 11 Aug 1998 10:42:17 -0700 Organization: UConn School of Pharmacy Lines: 59 Sender: daemon@net.bio.net Distribution: world Message-ID: <35CFC57D.167E@uconnvm.uconn.edu> NNTP-Posting-Host: net.bio.net This came to me today, so I thought I'd fwd it to this group. > I am writing to ask for your help in identifying suitable > candidates for post-doctoral positions in my research group, > available immediately. The suitable candidate desires to develop > skills (or obtain further experience) in the use of modern NMR > and computational methods for the determination of high resolution > structures of peptides and proteins (and their complexes). At a > minimum, the candidate should have some experience with the > utilization of NMR, for structure identification or characterization. > Experience with Unix workstations and molecular modeling or > handling/purification of peptides/proteins would be advantageous. > These positions are funded by the NIH and local pharmaceutical > companies. > > Our research efforts are aimed at the characterization of the > bimolecular interaction between peptide hormones and their receptors. > The high resolution structures afforded by these efforts have allowed > for the rational design of peptide-based agents to either enhance or > inhibit the biological response of the receptor. Our approach is > multifaceted, involving spectroscopic (mainly NMR, both high-resolution > and solid-state, but also circular dichroism, electron paramagnetic > resonance, and fluorescence) and theoretical techniques (molecular > modeling, molecular dynamics simulations, novel computational > methods for structure refinement). The laboratory is well equipped > with new Avance 400 and 600 MHz spectrometers, ten SGI (O2/indy) > workstations, access to an SGI Origin 2000 for simulations, and a > wet-lab for biochemistry, peptide chemistry, and genetic work. > > I would appreciate it if you could post this letter and/or bring > these positions to the attention of anyone in your laboratory who may > be interested. > > I thank you for your time. > > Sincerely, > > Dale > > Dale Mierke > Upjohn Professor of Medical Science > Dept. of Molecular Pharmacology > Division of Biology & Medicine > and > Department of Chemistry > Brown University > Providence, RI 02912 > > voice: (401) 863-2139 > fax: (401) 863-1595 > > Dale_Mierke@brown.edu > > -- -- David G. Rhodes O==O PHONE 860-486-5413 School of Pharmacy; U-92 O==O FAX 860-486-4998 University of Connecticut O==O Email rhodes@uconnvm.uconn.edu Storrs, CT 06269 O==O From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Newsgroups: bionet.biophysics Path: biosci!agate!newsfeed.berkeley.edu!howland.erols.net!ix.netcom.com!atlantis From: atlantis@netcom.com (JJ Miranda) Subject: Re: Energy of a thought Message-ID: Organization: Netcom On-Line Services X-Newsreader: TIN [version 1.2 PL2] References: <01bdc4fa$69daffb0$5407f79d@pmed073> Date: Tue, 11 Aug 1998 06:53:01 GMT Lines: 22 Sender: atlantis@netcom3.netcom.com Dear Josef, One problem: it's impossible to quantitate and measure one "thought." Heck, biologists don't even know what exactly a thought is... However, there has been a great deal of study regarding what happens when someone thinks about something. It's not the study of one thought per se, but rather the study of the thinking process. During the thinking process, certain activities (neuron firing, etc.) occur. Try looking up some of the studies done on brain field potentials and the work on the imaging of those activities and that might tell you more. Sincere regards, JJ Miranda Josef Riegebauer (riegebau@avl.com) wrote: : Has anybody an idea of how much energy or power consumption a normal human : thought produces or needs ? Any literature or book reference on that topic : ? : Regards, : Josef From owner-biophysics@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!howland.erols.net!news-peer.gip.net!news.gsl.net!gip.net!portc01.blue.aol.com!portc02.blue.aol.com!pitt.edu!not-for-mail From: Terry Morris Newsgroups: bionet.biophysics Subject: Products of ions and all that... Date: Tue, 11 Aug 1998 10:31:25 -0400 Organization: University of Pittsburgh Lines: 71 Message-ID: <35D055BD.A3F9B49B@pitt.edu> NNTP-Posting-Host: opossum.dental.pitt.edu Mime-Version: 1.0 Content-Type: multipart/alternative; boundary="------------DD3729C9D3B089238337E6E0" X-Mailer: Mozilla 4.05 [en] (Win95; I) --------------DD3729C9D3B089238337E6E0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Ok you clever people, You know that equilibrium equation we all were taught in chemistry class: The product of the PRODUCTS divided by the product of the REACTANTS is a constant. This has bugged me for years and I'm finally comming out of the closet about it (Don't you just hate it when formulas are simply given. I've been told that the equilibria equation was determined empirically, end of story. Nah!). How can this result be interpreted in terms of what is going on at the molecular level; why do we multiply the species concentrations together? Beacuse, in mathematical terms, when you multiply pairs of numbers together from say a range of integers between 1 and ten, the greatest value occurs at 5 x 5 = 25. So, what this formula is saying is that the value of the numerator or denominator is at maximum went those species are in equal quantities. What does this model in terms of molecule pairs interacting? I have some vague notions of my own about the the maxium proportion of collisions between species pairs taking place when they are in equal quantity. But I have never seen these questions addressed in any text, and I dont have the math or physics background to begin to work it out myself. If anyone can be bothered to post their thoughts or authorative knowlege on this I may avoid having therapy. Thanks, Terry Morris --------------DD3729C9D3B089238337E6E0 Content-Type: text/html; charset=us-ascii Content-Transfer-Encoding: 7bit Ok you clever people,

You know that equilibrium equation we all were taught in chemistry class: The product of the PRODUCTS divided by the product of the REACTANTS is a constant.  This has bugged me for years  and I'm finally comming out of the closet about it (Don't you just hate it when formulas are simply given. I've been told that the equilibria equation was determined empirically, end of story.  Nah!).  How can this result be interpreted in terms of what is going on at the molecular level; why do we multiply the species concentrations together?  Beacuse, in mathematical terms, when you multiply pairs of numbers together from say a range of integers between 1 and ten, the greatest value occurs at 5 x 5 = 25. So, what this formula is saying is that the value of the numerator or denominator is at maximum went those species are in equal quantities.  What does this model in terms of molecule pairs interacting?

I have some vague notions of my own about the the maxium proportion of collisions between species pairs taking place when they are in equal quantity.  But I have never seen these questions addressed in any text, and I dont have the math or physics background to begin to work it out myself.

If anyone can be bothered to post their thoughts or authorative knowlege on this I may avoid having therapy.

Thanks,  Terry Morris
 
  --------------DD3729C9D3B089238337E6E0-- From owner-biophysics@net.bio.net Tue Aug 11 23:00:00 1998 Path: biosci!rutgers!rockyd.rockefeller.edu!news-nysernet-5.sprintlink.net!news-dc-2.sprintlink.net!news-east.sprintlink.net!news-peer.sprintlink.net!news.sprintlink.net!howland.erols.net!pln-e!spln!extra.newsguy.com!newsp.newsguy.com!enews2 From: Harold Hauer Newsgroups: sci.bio.technology,bionet.neuroscience,bionet.general,bionet.biophysics,bionet.diagnosis,sci.engr.biomed Subject: Re: Fast-scan Voltammetry Date: Tue, 11 Aug 1998 23:48:42 -0400 Organization: http://extra.newsguy.com Lines: 16 Message-ID: <35D1109A.3CFE5446@ravenet.com> References: <35D0D3D0.9950AE0@bu.edu> NNTP-Posting-Host: p-434.newsdawg.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.04 [en] (Win95; I) To: luxiang Xref: biosci bionet.neuroscience:24136 bionet.general:30561 bionet.biophysics:4331 Check out the following URL:http://www.bioanalytical.com/ Harold luxiang wrote: > Hi There > > I want to know something about 'Fast-scan Voltammetry' for in vivo > detection of Dopamine, serotonin. can anybody help to offer any > resources on this tech? > > Thanks a lot! From owner-biophysics@net.bio.net Tue Aug 11 23:00:00 1998 Path: biosci!sloan.org!trance From: trance@sloan.org Newsgroups: bionet.biophysics Subject: POSTDOCS-COMP.MOLE.BIO ANNOUNCE Date: 12 Aug 1998 07:27:47 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 199 Sender: daemon@net.bio.net Distribution: world Message-ID: <000003FF.CW21520@sloan.org> NNTP-Posting-Host: net.bio.net Alfred P. Sloan Foundation and U.S. Department of Energy Postdoctoral Fellowships in Computational Molecular Biology (Round IV) APPLICATION DEADLINE: JANUARY 18, 1999 The Alfred P. Sloan Foundation and the U.S. Department of Energy believe that a nexus with exceptional scientific potential is emerging between the powerful theoretical and practical tools of molecular biology and the revolutionary power of modern computational techniques. However, too few scientists possess the cross-disciplinary skills in both molecular biology and computation that are needed to further such advances. The purpose of these fellowships is to catalyze career transitions into computational molecular biology from physics, mathematics, computer science, chemistry, and related fields. Ideal candidates will have strong educational backgrounds in such fields and wish to bring these backgrounds to bear upon computational molecular research questions. In exceptional cases, we will also consider applications from more traditional biological orientations in transition to computational molecular biology. Applicants already firmly rooted in computational molecular biology, or who are proposing to continue pursuit of research undertaken for their Ph.D.s, may be more appropriate candidates for other postdoctoral opportunities. This postdoctoral program is designed to give computationally sophisticated young scientists an intensive postdoctoral opportunity in an appropriate molecular biology laboratory. We particularly wish to encourage applications from those holding doctorates in mathematics, physics, computer science, chemistry, or other relevant fields who would like to develop the capacity to apply their computational sophistication to the complex problems that increasingly face molecular biology. The focus of this program is upon computational molecular biology related to data and information from studies of human and other genomes. Computational molecular biology is taken broadly to include the application of mathematics (continuous and discrete), statistics, probability, and computer science to fundamental problems of molecular biology. The goal is to foster interactions between the mathematical and biological sciences and to provide rigorous training for scientists in this new interdisciplinary area. Of special interest are important problems in structural biology and genome analysis, including analysis of protein and nucleic acid sequence, protein and nucleic acid structure, genome structure and maps, cross-species genome analysis, multi-genic traits, and structure-function relationships where the structures are from genomes, genes, or gene products. Applications will be reviewed by: Philip P. Green, University of Washington Barry Honig, Columbia University Leroy E. Hood, University of Washington Michael Levitt, Stanford University Michael S. Waterman, University of Southern California Awards will support up to two years of research work in an appropriate molecular biology department or laboratory in the U.S. or Canada selected by the applicant. The principal selection criteria will be the potential of the applicant and the proposed postdoctoral research and training plan for furthering rigorous computational approaches to analysis of important molecular biological problems, both theoretical and empirical. The capabilities of the proposed laboratory and senior scientist in computational molecular research, and support for the postdoctoral research by the senior scientist (department chair or laboratory director) will be an important element considered in selection. In addition, where possible, applicants are encouraged to seek a secondary faculty sponsor from the mathematical/computer sciences sector of the same campus. Only one proposal per applicant will be considered, and a senior scientist should endorse only one applicant for this competition. There are no formal application forms needed for this program. Further details and application procedures are as follows: Number, Starting Date and Grant Period: Up to 10 fellowships will be granted during 1999, each with a total budget of $100,000 (including indirect and overhead costs, which together will be limited to 15% of direct costs). These funds are to be spread over a grant period of two years ($50,000 per year). Selections for this fourth round will be announced in April, 1999. Funding may begin any time after September 1, 1999. Stipend: -$42,000 per year to Fellow, inclusive of benefits. -$ 1,500 per year in research expenses to be allocated at the discretion of the Fellow. -Institutional overhead of up to 15% of direct costs. Eligibility: Fellow - Applicants must be citizens or legal permanent residents of the United States. Ph.D. earned within the past 5 years or expected by June, 1999, in mathematics, physics, computer science, chemistry or other relevant fields. (Initiation of postdoc requires completion of Ph.D.) Applications to extend an existing postdoc cannot be considered. Institution - Non-profit private or public institution of higher education or research, located in the United States or Canada. Applicant must make formal arrangements with a senior scientist (e.g. laboratory director) at the institution where the postdoctoral fellowship would be held before applying for the award. Materials Needed for Application: From Applicant (8 copies, fully collated): Cover Page, including: - Applicant's name, address, telephone, fax and e-mail - Applicant's current department and institution - Title of proposed postdoctoral research project and institution at which it would be conducted (including mail and email addresses and telephone and fax numbers) - Planned starting date of postdoctoral fellowship - Applicant's Ph.D. granting institution and year of receipt (or date realistically expected) - Brief educational history indicating the year and institution of graduate study and of any postdoctoral research - Laboratory, department and institution in which postdoctoral fellowship would be held - Name, address and telephone of senior scientist - Names, addresses, telephone numbers, etc., of references Abstract of proposed research (not to exceed 300 words) Proposed research/training plan describing scientific importance of subject, with considerable specificity as to analytic methods and data to be employed, and reason for choice of proposed sponsoring scientist and institution (with a firm maximum of 1,500 words, including selected citations). If desired, copies of up to two reprints may be attached to each collated copy of proposal. Statement of applicant's reasons for interest in computational molecular biology, current career goals, and potential role of postdoctoral fellowship in attaining such goals (ca. 250 words). A summary of the major findings of the applicant's dissertation research (250 words). Curriculum vitae including educational background, topic of doctoral dissertation, positions held to date, scientific awards and grants received citing source, duration and amount (direct costs),full titles, and references of all publications. Formal institutional endorsement of proposal may be included, but is not required unless and until a formal award offer has been made. A stamped, self-addressed postcard (if applicant desires) to confirm that application materials have been received (allow at least 3 weeks for processing; no telephone calls, please). All applications should be final and complete; no substitutions or additions. From Sponsoring Senior Scientist (8 copies, fully collated): Letter of agreement to host and supervise the research of postdoctoral applicant, including any necessary institutional clearances, e.g. animal experimentation, human subjects, recombinant DNA, etc. Letter must include qualitative comments concerning scientific merit of proposed research and training plan. Brief description (500 words) of current research, sources of funding, relevance of applicant's proposed research, and personnel with whom applicant would work. Curriculum vitae including educational background, current and former positions, scientific awards and grants received citing source, duration and amount (direct costs), full titles and references of publications related to computational molecular biology. From References (8 copies): The applicant must request reference letters from three scientists (excluding sponsoring scientist) in relevant disciplines who are knowledgeable about applicant's capabilities and previous research, and to whom he/she has sent a copy of the research/training plan proposed for the postdoctoral fellowship. If possible, one of these three should have personal knowledge of the applicant's doctoral research, and all must comment on the applicant's summary of the major findings of his/her recent research. Reference letters should include comments on overall ranking of applicant, e.g. top 1% of Ph.D.s, top 10%, etc. It is the applicant's responsibility to assure that reference letters (8 copies) are sent. Deadline and Announcements: The deadline for receipt of all application materials from applicant, sponsoring scientist, and related reference letters is January 18, 1999 (firm). Announcements will be made by April, 1999. Send Application To: Dr. Michael S. Teitelbaum Sloan/DOE Joint Postdoctoral Fellowships in Computational Molecular Biology Alfred P. Sloan Foundation 630 Fifth Avenue, Suite 2550 New York, NY 10111-0242 From owner-biophysics@net.bio.net Tue Aug 11 23:00:00 1998 Message-ID: <35D1440B.620BC4DE@pyl.unibe.ch> Date: Wed, 12 Aug 1998 09:28:12 +0200 From: Franco Del Principe Organization: University of Bern X-Mailer: Mozilla 4.04 (Macintosh; I; PPC) MIME-Version: 1.0 Newsgroups: bionet.biophysics Subject: Gramicidin D Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit NNTP-Posting-Host: pylm59.unibe.ch Lines: 29 Path: biosci!agate!newsfeed.berkeley.edu!news.maxwell.syr.edu!news-ge.switch.ch!news-zh.switch.ch!news.unibe.ch!pylm59.unibe.ch Hi everybody, lately I tried to incorporate the sodium ionophore Gramicidin D into rat heart cells in culture to calibrate intracellular sodium. However, there was no incorporation as measured with fluorescence of intracellular SBFI (fluorescent sodium indicator). That is, the solution switch from 140mM Na+ to 0 Na+ had no effect. Gramicidin D was present in the extracellular solution at 2 micrograms/ml with no divalents (1mM EGTA). Does anybody have suggestions on what went possibly wrong? Or any hints how to incorporate Gramicidin D in these cells? Is Ca++ required for incorporation? How long do I have to wait for incorporation to occur at 22 centigrade? I am grateful for any comment Cheers Franco ----------------------------------------------------------------------- Franco Del Principe, Ph.D. Tel +41 31 631 87 17 University of Berne Fax +41 31 631 46 11 Department of Physiology e-mail delprincipe@pyl.unibe.ch Buhlplatz 5 CH-3012 Bern Switzerland ----------------------------------------------------------------------- From owner-biophysics@net.bio.net Tue Aug 11 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!logbridge.uoregon.edu!news.acsu.buffalo.edu!acsu.buffalo.edu!not-for-mail From: Brian M Burkhart Newsgroups: bionet.biophysics Subject: Re: HIGH-TECH CRIME SYNDICATE IN OHIO Date: Wed, 12 Aug 1998 14:59:53 -0400 Organization: Hauptman-Woodward Medical Research Institute Lines: 30 Message-ID: <35D1E629.1AAF34BB@hwi.buffalo.edu> References: <1998081017595000.NAA00205@ladder01.news.aol.com> NNTP-Posting-Host: galen.hwi.buffalo.edu Mime-Version: 1.0 Content-Type: multipart/alternative; boundary="------------4CC7552346E4A439052D966B" X-Mailer: Mozilla 4.05C-SGI [en] (X11; I; IRIX64 6.2 IP28) --------------4CC7552346E4A439052D966B Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit This person should meet the TRKreske guy with his conspiracy theories!! -- Brian M Burkhart, Ph.D. Hauptman-Woodward Medical Research Institute 73 High Street Buffalo, NY 14203 Phone: (716)856-9600 x313 FAX: (716)852-6086 --------------4CC7552346E4A439052D966B Content-Type: text/html; charset=us-ascii Content-Transfer-Encoding: 7bit This person should meet the TRKreske guy with his conspiracy theories!! 

-- 
Brian M Burkhart, Ph.D.
Hauptman-Woodward Medical Research Institute
73 High Street Buffalo, NY 14203
Phone: (716)856-9600 x313  FAX: (716)852-6086
  --------------4CC7552346E4A439052D966B-- From owner-biophysics@net.bio.net Tue Aug 11 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!howland.erols.net!bloom-beacon.mit.edu!senator-bedfellow.mit.edu!usenet From: "David F. Green" Newsgroups: bionet.biophysics Subject: Re: Products of ions and all that... Date: Wed, 12 Aug 1998 13:13:22 -0400 Organization: Massachusetts Institute of Technology Lines: 79 Message-ID: <35D1CD32.A7C8FF66@lms.mit.edu> References: <35D055BD.A3F9B49B@pitt.edu> NNTP-Posting-Host: born.lms.mit.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.05 [en] (X11; U; Linux 2.0.30 i686) Terry Morris wrote: > Ok you clever people, > > You know that equilibrium equation we all were taught in chemistry > class: The product of the PRODUCTS divided by the product of the > REACTANTS is a constant. This has bugged me for years and I'm > finally comming out of the closet about it (Don't you just hate it > when formulas are simply given. I've been told that the equilibria > equation was determined empirically, end of story. Nah!). How can > this result be interpreted in terms of what is going on at the > molecular level; why do we multiply the species concentrations > together? Beacuse, in mathematical terms, when you multiply pairs of > numbers together from say a range of integers between 1 and ten, the > greatest value occurs at 5 x 5 = 25. So, what this formula is saying > is that the value of the numerator or denominator is at maximum went > those species are in equal quantities. What does this model in terms > of molecule pairs interacting? > > I have some vague notions of my own about the the maxium proportion of > collisions between species pairs taking place when they are in equal > quantity. But I have never seen these questions addressed in any > text, and I dont have the math or physics background to begin to work > it out myself. > > If anyone can be bothered to post their thoughts or authorative > knowlege on this I may avoid having therapy. > > Thanks, Terry Morris > > Equilibrium constants can be derived using quite basic thermodynamics for simple systems. If you're really interested in understanding where they come from, I'd suggest you look through an introductory Physical Chemistry text. Atkins, "Physical Chemistry," 5th ed. gives a pretty good treatment that you can follow either with or without the detailed derivations (the math is generally set aside from the rest of the text, and is not absolutely required to follow the arguments). Chemical Equilibrium is covered in chapter 9, but you'll want to read at least the first 5 chapters for a background in thermodynamics before jumping into equilibrium. Where equilibrium constants come from is the combination of several points: 1. At equilibrium the free energy of a system is 0. 2. The molar reaction free energy for a given transformation is given by summing the molar chemical potentials of each component (i.e. reactants and products), multiplied by the coefficient in the balanced equation, and made negative for reactants. 3. The chemical potential (u) of a substance at arbitrary temperature is given by u=u0+RTln(a), where u0 is the chemical potential at standard state, R is the gas constant, T is temperature, and a is the activity of the substance. These combine directly to give the thermodynamic equilibrium constant, which has the form you know, but all concentrations and pressures are replaced by activity. Activities are related to concentrations by activity coefficients, and to pressures through a conversion to fugacity followed by application of the desired gas law. In many cases where temperatures aren't too low, pressures and concentrations aren't too high, and there aren't a lot of "spectator" species present, activities can be more or less interpretted as conentrations and/or pressures (i.e. activity coefficients are 1, ideal gases assumed). I hope this helps. -- ************************************************ David F. Green Department of Chemistry Massachusetts Institute of Technology 77 Massachusetts Ave., Rm. 6-133 Cambridge, MA 02139 E-mail: dfgreen@lms.mit.edu Phone: (617) 258-6229 ************************************************ From owner-biophysics@net.bio.net Wed Aug 12 23:00:00 1998 Path: biosci!pravda.ucr.edu!awabi.library.ucla.edu!208.134.241.18!newsfeed.internetmci.com!198.138.0.5!newshub.northeast.verio.net!newsfeed1.earthlink.net!nntp.earthlink.net!not-for-mail From: specpress@earthlink.net (SCIENCE-WEEK Editors) Newsgroups: bionet.neuroscience,bionet.biophysics,bionet.cellbiol,bionet.general,sci.misc Subject: SCIENCE-WEEK July 3, 1998 issue now available free Date: Wed, 12 Aug 1998 23:16:18 GMT Organization: Science-Week Lines: 30 Message-ID: <6qt7ru$oeu$2@ash.prod.itd.earthlink.net> Reply-To: specpress@earthlink.net NNTP-Posting-Host: 1cust201.tnt5.chi5.da.uu.net X-Newsreader: Forte Free Agent 1.0.82 Xref: biosci bionet.neuroscience:24147 bionet.biophysics:4336 bionet.cellbiol:9970 bionet.general:30570 The July 3, 1998 issue of SCIENCE-WEEK is now available free at URL: Contents as follows: July 3, 1998 ------------------------------------------------------ 1. On Science and the Control of Aids 2. On Black Holes 3. Mars Pathfinder Mission: A Summary 4. On the Origin of Hydrothermal Megaplumes 5. On Polymer Rheology 6. Attraction Between Like-Charged Spheres in a Charged Pore 7. Origin of Life: A Model for the Universal Ancestor 8. On Prokaryotes in the Biosphere 9. Parenting and Survival in Anthropoid Primates 10. On Alcohol in the Western World ----------------------------------------------------------------- The archive of back issues to May 1, 1997 is free and available at the same URL. The Editors SCIENCE-WEEK A Weekly Digest of the News of Science editors@scienceweek.com http://scienceweek.com From owner-biophysics@net.bio.net Sat Aug 15 23:00:00 1998 Path: biosci!news.stanford.edu!logbridge.uoregon.edu!newsm.ibm.net!ibm.net!news.prtc.net!news From: "angeles" Newsgroups: bionet.biophysics Subject: How could cell use the kinetic energy of molecules in diffusion for endergonic reactions? Date: 16 Aug 1998 05:33:17 GMT Organization: prtc.net Lines: 7 Message-ID: <01bdc8d8$16b69ec0$b94b92cc@prtc.net.prtc.net> NNTP-Posting-Host: 204.146.75.185 X-Newsreader: Microsoft Internet News 4.70.1155 How could cells uses the kinetic energy of molecules in diffusion for endergonic reactions? How can it capture this energy? And those it waste energy while trying to mantain itself from reaching equilibrium in diffusion? From owner-biophysics@net.bio.net Sun Aug 16 23:00:00 1998 Path: biosci!news.stanford.edu!logbridge.uoregon.edu!news.maxwell.syr.edu!nntp.news.xara.net!xara.net!interpath.net!news-relay.ncren.net!ussun2n!news@ussun2n.glaxo.com From: Mike Lenik Newsgroups: bionet.biophysics Subject: biophysics Date: Mon, 17 Aug 1998 17:01:42 +0100 Organization: Glaxo Wellcome plc Lines: 93 Message-ID: <35D853E6.10D56A13@rocketmail.com> NNTP-Posting-Host: 147.184.168.172 Mime-Version: 1.0 Content-Type: multipart/alternative; boundary="------------0656CF1526922211FB97B25A" X-Mailer: Mozilla 4.05 [en] (WinNT; I) --------------0656CF1526922211FB97B25A Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit http://www.uea.net Dear readers, the reason we have posted this message on a science newsgroup t is because we require people with a knowledge and interest in new technologies.. Who are we? We are Earth New Tech, a division of the United Earth Alliance that deals with developing new technologies that will hopefully improve the standard of life for people around the world. What is the UEA? A non profit, international, multi function organisation. How can you help? Our members use their skills to help the UEA. If you are interested in science then you can help us by sharing your knowledge and views We really do need you. In addition, UEA members are able to vote and change the constitution of the UEA. How much does it cost? Nothing. There is no membership fee. All we ask is that you use you skills and knowledge to help us. Where? For more information please visit http://www.uea.net Thanks Mike Lenick -- United Earth Alliance Small Step. Right Direction. http://www.uea.net --------------0656CF1526922211FB97B25A Content-Type: text/html; charset=us-ascii Content-Transfer-Encoding: 7bit

http://www.uea.net

Dear readers,
the reason we have posted this message on a science newsgroup t is because we require people with a knowledge and interest in new technologies..

Who are we?
We are Earth New Tech, a division of the United Earth Alliance that deals with developing new technologies that will hopefully improve the standard of life for people around the world.

What is the UEA?
A non profit, international, multi function organisation.

How can you help?
Our members use their skills to help the UEA. If you are interested in science then you can help us by sharing your knowledge and views We really do need
you. In addition, UEA members are able to vote and change the constitution of the UEA.

How much does it cost?
Nothing. There is no membership fee. All we ask is that you use you skills and knowledge to help us.

Where?
For more information please visit
http://www.uea.net

Thanks

Mike Lenick

--
United Earth Alliance
Small Step. Right Direction.
http://www.uea.net
  --------------0656CF1526922211FB97B25A-- From owner-biophysics@net.bio.net Sun Aug 16 23:00:00 1998 Path: biosci!rz.uni-jena.de!b5wojo From: b5wojo@rz.uni-jena.de (Johannes Woestemeyer) Newsgroups: bionet.biophysics Subject: radio-isotope course Date: 17 Aug 1998 09:00:22 -0700 Organization: FSU Jena - Microbiology Lines: 17 Sender: daemon@net.bio.net Distribution: world Message-ID: <35D852BC.3F0E@rz.uni-jena.de> NNTP-Posting-Host: net.bio.net Dear colleagues, during my preparations for a freshly designed practical course in radioisotope handling I would be interested in informations frm other institutes, experiments, text books, internet sources and similar that might help to improve teaching in this field. Any hints or advice for me? Thank you for bothering, Prof. Joh. Woestemeyer Inst. Microbiology/Microbe genetics Friedrich-Schiller University Jena Neugasse 24 D-07743 Jena e-mail: b5wojo@rz.uni-jena.de From owner-biophysics@net.bio.net Mon Aug 17 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!news.maxwell.syr.edu!nntp.news.xara.net!xara.net!server6.netnews.ja.net!server4.netnews.ja.net!server2.netnews.ja.net!pegasus.csx.cam.ac.uk!not-for-mail From: Yu Wai Chen Newsgroups: bionet.biophysics Subject: Re: Surface Plasmon Resonance Date: Tue, 18 Aug 1998 14:25:25 +0100 Organization: MRC Centre for Protein Engineering Lines: 33 Message-ID: <35D980C4.85BC3FFD@mrc-lmb.cam.ac.uk> References: <35CB56FD.CAEE4D49@gwdg.de> NNTP-Posting-Host: i11.mrc-lmb.cam.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.05 [en] (X11; I; IRIX64 6.2 IP28) > Can anyone here explain me in short words the principles of Surface > Plasmon Resonance? I'm, a biologist working with proteins and DNA on a > BIAcore, and I've to admit I haven't understood the principles of the > phenomena. So maybe you can give me a quick introduction - only to know > what happens in this black box machine ... ;-) When light enters from one face of a prism it usually get diffracted into a rainbow when it leaves the prism. However, when the incident angle is at a "critical angle", most of the light will get reflected rather than diffracted before it exits the prism. This is "total internal reflection". SPR exploits this physical phenomenone. Now people found that the critical angle changes if we modified the nature of the air/prism interface at where the total internal reflection occurs. Put it simpler, if you, say, paint a coat to the prism, this coat of paint will alter the critical angle. In BIACORE, the machine detects changes in the critical angle in response to the changes (increase) in the nature of the material at the prism/liquid interface. When you imobilise, say an antigenic protein onto the prism, the molecular mass increases and you detect an increase in signal. When you next let an antibody binds to the immobilised antigen, the prism/liquid interface contains yet more mass and further give rise to a higher signal. End of story. Wai -- =================================================================== Yu Wai CHEN, Ph.D. .................. email: ywc@mrc-lmb.cam.ac.uk Centre for Protein Engineering, tel: 44-(1223) 402148 MRC Centre, Cambridge CB2 2QH, U.K. fax: 44-(1223) 402140 WWW homepage: http://www.mrc-cpe.cam.ac.uk/people/wai.html From owner-biophysics@net.bio.net Tue Aug 18 23:00:00 1998 Path: biosci!daresbury!not-for-mail From: Newsgroups: bionet.biophysics Subject: m1419@hotmail.com Date: 19 Aug 1998 04:53:52 +0100 Lines: 58 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <6rdi8g$kbq@mserv1.dl.ac.uk> Original-To: Friend@public.com BENCHMARK PRINT SUPPLY 1091 REDSTONE LANE ATLANTA GA 30338 CALL----> 770-399-0953 FOR TONER SUPPLIES ORDERS/PRICING ONLY CALL----> 770-399-5505 CUSTOMER SERVICE/SUPPORT ISSUES CALL----> 770-399-5614 E-MAIL REMOVAL COMPLAINTS LINE OR BY E-MAIL TO -----> http://remove-list.com OUR LASER PRINTER/FAX/COPIER TONER CARTRIDGE PRICES NOW AS LOW AS $39 & UP. 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PLEASE PLEASE PLEASE MAKE NOTE OF THE FOLLOWING BEFORE YOU CALL: -----> WE DO NOT HAVE CATALOGS OR PRICE LISTS BECAUSE OUR PRICES CHANGE WEEKLY!! -----> WE DO NOT FAX QUOTES OR PRICES BECAUSE OUR ORDER LINE IS NOT SET UP TO DO THAT -----> WE DO NOT SELL TO RESELLERS OR BUY FROM DISTRIBUTERS -----> WE DO NOT CARRY : BROTHER -MINOLTA-KYOSERA- PANASONIC - XEROX - FUJITSU - OKIDATA - SHARP!! -----> WE DO NOT CARRY ANY COLOR PRINTER SUPPLIES!!!!! -----> WE DO NOT CARRY DESKJET/INKJET OR BUBBLEJET SUPPLIES!!!! NEW,NEW,NEW $10 MAIL IN REBATE ON SELECTED CARTRIDGES SIMPLY ORDER YOUR NEW CARTRIDGE, WHEN IT ARRIVES MAIL BACK YOUR REBATE CERTIFICATE WITH ANY USED CARTRIDGE FOR INSTANT CREDIT WE ACCEPT ALL MAJOR CREDIT CARDS OR COD ORDERS CORPORATE ACCOUNTS AVAILABLE WITH APPROVED CREDIT ALL PACKAGES SHIPPED UPS GROUND UNLESS SPECIFIED OTHERWISE From owner-biophysics@net.bio.net Tue Aug 18 23:00:00 1998 Path: biosci!daresbury!not-for-mail From: Alex Spirov Newsgroups: bionet.biophysics Subject: <> is available Date: 19 Aug 1998 10:16:03 +0100 Lines: 87 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <6re54j$3pn@mserv1.dl.ac.uk> MIME-Version: 1.0 Original-To: "'bionet.info-theory'" , "'BIO-WWW'" , "'bionet.general'" , "'bionet.biophysics'" , "'bionet.biology.computational'" , "'bionet.molbio.evolution'" New release of electronic monograph is available now at http://www.geocities.com/ResearchTriangle/Thinktank/1765/monogr/monograph.html and at http://www.iephb.ru/~spirov/monograph.html ----------------------------------------------------------- <> [Electronic monograph] 1.Introduction: "Game of Morphogenesis". 2.Genes-Controllers of Morphogenesis. 2.1.Genes and Morphogenesis. 2.1.1.Sea urchin Early Expressed Genes. 2.1.2.Drosophila Segmentation Mechanisms. 2.1.2.1.Cues and Turing Models. 2.1.3.Vertebrate HOX-genes in Development (HOX-DB). 3.Genetic Networks (GeNet DataBase). 3.1.Drosophila Segmentation Networks. 3.1.1.A connectionist Models of Development. 3.1.2.Boolean Models. 3.2.Vertebrate HOX Networks (HOX-Pro DataBase). 4.Life and ALife Morphogenesis. 4.1.Morphogenesis Constrains. 4.1.1.Scaling, Regulations and Equifinality. 4.1.2.Regulative Morphogenesis. 4.2.Pattern and Form. 4.2.1.Turing Systems. 4.2.2.Non-Linear Kinetics of Transcription Machinery in Genetic Networks. 4.3.Electrically Active Insect Zigote. 4.4.Pattern-Form Interplay Models. 4.4.1.The Symmetry Breaking: Axis Tilting Phenomenon. 4.4.1.1.Movie of Simulation of Sea Urchin Gastrulation. 4.4.2.Morphogenesis at the Edge of Chaos. 4.5.Vertebrate Limb Morphogenesis. 4.6.Teratogenesis. 4.6.1.Polyradiate Flatworms. 4.6.2.Polyradiate Sea Urchins. 4.6.3.Earthworms Segmentation Aberrations. 4.6.4.Tetrapods Limb Abnormalities. 4.6.4.1.Organization Of Vertebrate Network Of Hox Genes And Limb Fate Map. 4.6.5.Morphogens & Teratogens. 5.Biological and Computer Evolution. 5.1.The Ways Of Evolution Of Ensembles Of Homeobox Genes-Controllers Of Development. 5.2.Evolution of Network of Insect's Segmentation Genes. ------------------------------------------------------------- Alexander V.Spirov (PhD) The Sechenov Institute of Evolutionary Physiology & Biochemistry, Thorez Pr. 44, St.Petersburg, 194223, Russia phone/fax +7 (812)552 3219; fax + 7 (812)552-3012 WWW http://www.iephb.ru/~spirov/; Email spirov@iephb.ru and Institute for High-Performance Computing & Data Bases, P.O. Box 71, St.Petersburg 194291, RUSSIA From owner-biophysics@net.bio.net Wed Aug 19 23:00:00 1998 From: "Arjen Schots" Subject: Two PhD positions Newsgroups: bionet.biophysics Organization: Wageningen Agricultural University Message-ID: <01bdcc13$f64f9ee0$7ca4e089@?.wau.nl> X-Newsreader: Microsoft Internet News 4.70.1161 NNTP-Posting-Host: 137.224.164.124 Date: 20 Aug 1998 10:24:46 +0100 X-Trace: 20 Aug 1998 10:24:46 +0100, 137.224.164.124 Lines: 83 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!howland.erols.net!surfnet.nl!wau.nl!137.224.164.124 Within the Laboratory of Biochemistry, Department of Biomolecular Sciences and the Laboratory for Monoclonal Antibodies, Department of Plant Sciences of the Wageningen Agricultural University TWO PhD positions are available in a project entitled: Development of multimode fluorescence correlation microscopy suitable for high throughput screening and applications in plant signal transduction research. This project is subsidised by the Technology Foundation and coordinated by the Council of the Geosphere and Biosphere sciences of the National research Council (reference nr. 805.02.752/790.44.797) Task description: The central objective is the development of a real multimode fluorescence correlation microscope (FCM). Implementation of novel technological developments in opto-electronics, accurate sample positioning, piezo-mechanical focussing at successive depths in the sample and insertion of multiple excitation and detection ports results in a confocal microscope which combines different modalities: (cross-) correlation spectroscopy diffusion mapping of fluorescent molecules, measurement of concentrations and interactions), quantitative time-lapse digital image microscopy (tracking fluorescent molecules in cells during their life cycle), three-dimensional image reconstruction (3D images of microscopic objects) and spectral imaging microscopy (to characterise emission spectra of microscopic objects). One application of FCM in (bio)technology is the use as a device to screen large numbers of samples. Present advances in biotechnology, biomedicine and chemistry require equipment to screen large numbers of samples both accurately and rapidly, particularly in those situations where biomolecular interactions are studied. FCM allows the screening of such interactions in minute (submicroliter) volumes using "single molecule" sensitivity. We will investigate this by screening antibodies, genetically fused to the green fluorescent protein (GFP) of the jelly fish Aequorea victoria, arising from selections of large antibody phage display libraries for binding capacities. A second application involves the use of the FCM as a research instrument in biology. We will investigate this by studying some molecular events in the sedentary nematode - plant interaction. Sedentary nematodes are endoparasites inducing feeding cells in the roots of host plants on which they fully rely to complete their life cycle. We have chosen to use this model system because one of the morphological characteristics of these cells is the lack of a central vacuole allowing detailed studies on processes in and around the nucleus. A typical feature of this intimate relationship is the triggering of the cell cycle in nematode feeding cells, which never show cell division. Using GFP under control of cell cycle promoters we will measure the buildup and trafficking of this protein. By fusing a red fluorescent and wild type GFP to, respectively, the cell cycle proteins cyclAt (a cyclin) and a cdc2a (a cyclin dependent) kinase we will study their interaction. In a next step the kinase activity of cdc2a will be investigated using a fluorescent substrate. In a final stage we will study the activity of auxin. This plant hormone is one of the key regulators of plant growth and development and as such affects the cell cycle. We recently obtained evidence that this is also true for nematode feeding cell development. Fluorescent auxin analogues will be used to investigate where and how it binds to cells and when the cell cycle is entered as a consequence of this action. The first PhD student will construct the multimode FCM starting from an existing fluorescence correlation system. Using FCS a high throughput screening system will be developed as described above. Two sampling principles will be developed. The first one is based on 96 (or 384) well plates and the second one is based on a continuous flow system using microcapillaries. Required: University degree in (bio)physics, (bio)physical chemistry or molecular sciences. Fluent in English. Experience with fluorescence microscopy and image analysis is a preference. The second PhD student will use FCM as a research instrument in biology focusing on the nematode-plant interaction as described above. Required: University degree in biology or molecular sciences. Fluent in English. Experience with molecular biological or cell biological techniques is a preference. Both PhD students will be supported by a technician. Information can be obtained by: Dr. A. Visser. Tel. Nr. +31-317-482862 e-mail: Ton.Visser@laser.bc.wau.nl Dr. A. Schots Tel. Nr. +31=317-485261 e-mail: Arjen.Schots@lma.nema.wau.nl Application: To apply for one of the above positionsplease send your curriculum vitae to Dr. A. Visser, Microspectroscopy Center, Laboratory of Biochemistry, Department of Biomolecular Sciences, Wageningen Agricultural University, Dreijenlaan 3, 6703 HA Wageningen. Or e-mail it to Ton.Visser@laser.bc.wau.nl From owner-biophysics@net.bio.net Wed Aug 19 23:00:00 1998 Path: biosci!IDT.NET!elemen19 From: elemen19@IDT.NET ("Greg Schliessmann") Newsgroups: bionet.biophysics Subject: sbscribe, & send info about your ezine Date: 20 Aug 1998 03:10:06 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 68 Sender: daemon@net.bio.net Distribution: world Message-ID: <199808201002.GAA17140@u2.farm.idt.net> Reply-To: elemen19@idt.net NNTP-Posting-Host: net.bio.net Hello, Please add me to your free ezine. Also... I'm creating an electronic book about ezine marketing (topics like why you should publish your own ezine, how to build your subscription base, how to advertise in other ezines, ect). Would you like to be included in it, for free? If you'd like to be included, I'll help you sell advertising in your ezine by listing your ezine in the free e-book. Plus, if you respond to my message and tell me you want the e-book, I'll send it to you free, even if you don't accept advertising. Here's how to be included... simply answer the following questions and mail it to office@jvmarketer.com. You can mail it to the address I wrote you from, but I get a lot of email there... so it would help to write me at office@jvmarketer.com If you wish to fill out the form via the web, go to: http://members.xoom.com/jvmarketer/ Here they are: >Your Name: >Your Ezine Name: >Your Website: >Your Email Subscription Address: >Your Email For Advertising Info: >Your Email For Article Submissions: >Your Personal Email Address: >Topic Of Your Ezine: >Circulation: >As of (what date): >Cost of Advertising: >Subscription growth per month: >Number of ads allowed in each issue: >Frequency of Ezine: >Date/Day Ezine Goes Out (i.e., every Friday): >Do you wish to be added to my free weekly ezine, Breakthrough Internet Marketing? sure/no way Okay... that's it. Just fill out this form and email it to office@jvmarketer.com. I promise it will be worth your while, because this e-book will be read by thousands of perfect prospects for your ezine advertising. Again, once you reply, I will register you to receive my e-book for free... I'll contact you immediately when it's ready (probably next week... I have all the articles written; this is the last thing I need). Thanks for your time. You'll find it to be worth it. -- Greg Schliesmann Publisher, Breakthrough Internet Marketing Weekly http://www.jvmarketer.com PS. I saw your ezine at http://www.meer.net/~johnl/e-zine-list/ an am contacting you after I have most of the other publishers. So please reply immediately because I want to have this finished tomorrow night. From owner-biophysics@net.bio.net Thu Aug 20 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!news.maxwell.syr.edu!netnews.com!news.idt.net!nntp.farm.idt.net!news From: Greg Schliesmann Newsgroups: bionet.biophysics Subject: RE: sbscribe, & send info about your ezine Date: Thu, 20 Aug 1998 21:34:41 -0500 Organization: IDT (Best News In The World) Lines: 11 Message-ID: <35DCDCC1.E94CDEAF@idt.net> NNTP-Posting-Host: ip55.milwaukee2.wi.pub-ip.psi.net Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.05 [en] (Win95; I) Someone posted this in my name. I did NOT post this... I sent a letter like this to some ezine publishers via email... however, I never posted anything like this on UseNet. Someone is impersonating me in attempt to destroy my business. They will never succeed. I want you to know that I did not post this message on UseNet. Thanks, (The Real) Greg Schliesmann From owner-biophysics@net.bio.net Thu Aug 20 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!newsfeed.internetmci.com!209.150.160.22!newsfeed.wli.net!208.10.192.30!nntp2.dejanews.com!nnrp1.dejanews.com!not-for-mail From: geos@goldrush.com Newsgroups: bionet.biophysics Subject: ASC Boston "in situ" SPM Demonstrations Date: Fri, 21 Aug 1998 22:45:22 GMT Organization: Deja News - The Leader in Internet Discussion Lines: 13 Message-ID: <6rkta2$li8$1@nnrp1.dejanews.com> NNTP-Posting-Host: 209.218.192.68 X-Article-Creation-Date: Fri Aug 21 22:45:22 1998 GMT X-Http-User-Agent: Mozilla/2.0 (compatible; MSIE 3.02; Windows 95) If you will be at ACS in Boston August 24-26. You are cordially invited to come see Molecular Imaging's technology advances for "in situ" scanning probe microscopy and sample characterization. Princeton Instruments is hosting these demonstrations booth # 1119. If you can not join us in Boston, please visit us at http://www.molec.com ______________________________________________________ George Sibbald MOLECULAR IMAGING World Leader: "In Situ" Scanning Probe Microscopy (STM, AFM, LFM, EFM, AC in liquid, Phase ....) (602) 753-4311 PS: Sign up for "in situ / in vitro SPM Tech Notes and Applications Newsletter http://molec.com/info/form.html -----== Posted via Deja News, The Leader in Internet Discussion ==----- http://www.dejanews.com/rg_mkgrp.xp Create Your Own Free Member Forum From owner-biophysics@net.bio.net Fri Aug 21 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!sunqbc.risq.qc.ca!newspeer.monmouth.com!rain.fr!bunny.easynet.fr!easynet-fr!news.easynet.fr!not-for-mail From: philimar@easynet.fr (Philippe MARQUIS) Newsgroups: bionet.biophysics Subject: Free software for printing graph papers Date: Sat, 22 Aug 1998 19:17:35 GMT Organization: [posted via] Easynet France Lines: 24 Message-ID: <6rn5fp$l5p$4@buggy.easynet.fr> Reply-To: philimar@easynet.fr NNTP-Posting-Host: pop-metz-28.pops.easynet.fr X-Newsreader: Forte Free Agent 1.0.82 With the new free and unlimited version of GRAPHPAP software you can print by yourself any kind of graph paper according your own formats. You can choose the graph size, position and orientation on the paper sheet. The scales can be linear or logarithmic with adjustable graduations. GRAPHPAP is useful for students, teachers, researchers, laboratory personnel ... It is the costless and definitive answer to the difficulty of getting provided with multi-formats graduated papers. The software is downloadable from the author's website : http://perso.easynet.fr/~philimar/ ---------------------------------------------- Dr Philippe Marquis Centre hospitalier regional 57000 METZ - FRANCE E-mail: philimar@easynet.fr --------------------------------------------- From owner-biophysics@net.bio.net Fri Aug 21 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!howland.erols.net!vixen.cso.uiuc.edu!newsfeed.acns.nwu.edu!news.acns.nwu.edu!news From: Richard Schuerger Newsgroups: bionet.biophysics Subject: neuroscience site Date: Sat, 22 Aug 1998 16:48:50 -0500 Organization: Northwestern University, Evanston, IL, US Lines: 29 Message-ID: <35DF3CC2.7298B10@nwu.edu> NNTP-Posting-Host: pine009200.nuts.nwu.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.04 [en] (Win95; I) I maintain a Neuroscience Internet Guide at The Mining Co. with information about neuroscience, neurobiology, and neurology from both a basic science and a health perspective. I write features articles that examine topical neuroscience stories, review basics of neuroscience, or aspects of its history. I also maintain a large collection of links to neuroscience resources on the net, including neurological disease and neuroscience education. The main page of the site is: http://neuroscience.miningco.com/ Some features of the site that may be of interest: Feature Articles http://neuroscience.miningco.com/library/weekly/mpreviss.htm Links to Neuroscience/Neurology Resources http://neuroscience.miningco.com/mlibrary.htm Chat Room http://neuroscience.miningco.com/mpchat.htm Bulletin Board http://neuroscience.miningco.com/mpboards.htm Newsletter http://neuroscience.miningco.com/gi/pages/mmail.htm From owner-biophysics@net.bio.net Mon Aug 24 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!news.maxwell.syr.edu!nntp.news.xara.net!xara.net!server6.netnews.ja.net!daresbury!not-for-mail From: romano@bellatrix.pcl.ox.ac.uk (Romano Kroemer) Newsgroups: bionet.biophysics Subject: Q: structure of protein complex + alanine scan Date: 25 Aug 1998 16:22:18 +0100 Lines: 23 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <6rukra$i14@mserv1.dl.ac.uk> Original-To: bioforum@dl.ac.uk, biophys@dl.ac.uk, proteins@dl.ac.uk, xtal-log@dl.ac.uk, str-nmr@dl.ac.uk Hi all, can anyone point me to references concerning the following topic: Systematic "alanine scanning" studies on protein complexes for which the (wild type)structure is known (by NMR/X-ray). I am aware of two examples: human growth hormone + receptor anti-hen egg white lysozyme (HEL) antibody + HEL Thanks! Romano Kroemer -- =============================================================================== Dr. Romano T. Kroemer Phys. & Theoret. Chem. Lab. University of Oxford South Parks Rd. | Tel: ++44-1865-275475 Oxford OX1 3QZ | Fax: ++44-1865-275410 England, U.K. | Email: romano@bellatrix.pcl.ox.ac.uk =============================================================================== From owner-biophysics@net.bio.net Tue Aug 25 23:00:00 1998 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!newshub.northeast.verio.net!news3.cac.psu.edu!usenet From: me Newsgroups: bionet.biophysics Subject: test, disregard Date: Wed, 26 Aug 1998 13:33:34 -0400 Organization: Penn State University, Center for Academic Computing Lines: 1 Message-ID: <35E446EE.7DEA6377@psghs.edu> NNTP-Posting-Host: cml14-37.hmc.psghs.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.01 [en] (Win95; I) X-Priority: 3 (Normal) testing From owner-biophysics@net.bio.net Tue Aug 25 23:00:00 1998 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.bbnplanet.com!news-peer.gip.net!news.gsl.net!gip.net!news.idt.net!nntp2.cerf.net!nntp3.cerf.net!news.sdsc.edu!news.tc.cornell.edu!news3.cac.psu.edu!usenet From: lab_user Newsgroups: bionet.biophysics Subject: Test Date: Wed, 26 Aug 1998 13:31:50 -0400 Organization: Penn State University, Center for Academic Computing Lines: 1 Message-ID: <35E44686.7B1BAAEF@psghs.edu> NNTP-Posting-Host: cml14-37.hmc.psghs.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.01 [en] (Win95; I) X-Priority: 3 (Normal) Testing access From owner-biophysics@net.bio.net Wed Aug 26 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!howland.erols.net!newsfeed.internetmci.com!204.238.120.130!news-feeds.jump.net!nntp2.dejanews.com!nnrp1.dejanews.com!not-for-mail From: rshigeta@yahoo.com Newsgroups: bionet.biophysics Subject: Re: Q: structure of protein complex + alanine scan Date: Thu, 27 Aug 1998 16:45:47 GMT Organization: Deja News - The Leader in Internet Discussion Lines: 13 Message-ID: <6s42fr$lce$1@nnrp1.dejanews.com> References: <6rukra$i14@mserv1.dl.ac.uk> NNTP-Posting-Host: 134.174.243.42 X-Article-Creation-Date: Thu Aug 27 16:45:47 1998 GMT X-Http-User-Agent: Mozilla/4.5b1 [en] (X11; I; IRIX64 6.2 IP28) > Hi all, > > can anyone point me to references concerning the following topic: > there is a new overview paper in JMB which has good references: Bogen and Thorn or Thorn and Bogen... -----== Posted via Deja News, The Leader in Internet Discussion ==----- http://www.dejanews.com/rg_mkgrp.xp Create Your Own Free Member Forum From owner-biophysics@net.bio.net Fri Aug 28 23:00:00 1998 Path: biosci!daresbury!not-for-mail From: Alex Spirov Newsgroups: bionet.biophysics Subject: New release of the "HOX Pro" database Date: 29 Aug 1998 15:49:43 +0100 Lines: 32 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <6s94e7$n5o@mserv1.dl.ac.uk> MIME-Version: 1.0 Original-To: "'bionet.info-theory'" , "'BIO-WWW'" , "'bionet.general'" , "'bionet.biophysics'" , "'bionet.biology.computational'" , "'bionet.molbio.evolution'" New release of the "HOX Pro" database is available now at http://www.mssm.edu/molbio/hoxpro/new/hox-pro00.html and http://www.iephb.ru/~spirov/hox_pro/hox-pro00.html The HOX-Pro is aimed at 1) analysis and classification of regulatory regions in diverse homeobox and related genes-controllers of invertebrate and vertebrate development; 2) comparative analysis of organisation of HOX clusters and "hox-based" genetic networks for C.elegans, sea urchins, Drosophila and vertebrates; 3) analysis of phylogeny and evolution of homeobox genes and clusters. ------------------------------------------------------------- Alexander V.Spirov (PhD) The Sechenov Institute of Evolutionary Physiology & Biochemistry, Thorez Pr. 44, St.Petersburg, 194223, Russia phone/fax +7 (812)552 3219; fax + 7 (812)552-3012 WWW http://www.iephb.ru/~spirov/; Email spirov@iephb.ru and Institute for High-Performance Computing & Data Bases, P.O. Box 71, St.Petersburg 194291, RUSSIA From owner-biophysics@net.bio.net Fri Aug 28 23:00:00 1998 Path: biosci!rutgers!gatech!205.252.116.205.MISMATCH!howland.erols.net!news-peer.sprintlink.net!news-nysernet-15.sprintlink.net!news.sprintlink.net!24.129.0.46!newsfeed.se.mediaone.net!news2.jacksonville.net.POSTED!not-for-mail From: Dana.Delany@Nude.Here.com Newsgroups: bionet.biophysics Subject: ALL FREE MEMBERSHIP SITE 45406 Message-ID: <29089805.4105@Nude.Here.com> Organization: Distribution: World Lines: 11 Date: Sat, 29 Aug 1998 09:42:47 GMT NNTP-Posting-Host: 24.129.42.110 NNTP-Posting-Date: Sat, 29 Aug 1998 05:42:47 EDT http://cristyshouse.fsn.net WE HAVE A BRAND NEW SITE THAT YOU WILL LOVE. THERE ARE 4 GIRLS LIVING IN A HOUSE WITH CAMERAS IN EVREY ROOM. SEE THEM DO EVERYTHING YOU CAN IMAGINE. IT IS ALL FREE TAKE A PEEK. http://cristyshouse.fsn.net http://cristyshouse.fsn.net 9Fz From owner-biophysics@net.bio.net Sat Aug 29 23:00:00 1998 Newsgroups: bionet.biophysics Path: biosci!agate!newsfeed.berkeley.edu!howland.erols.net!ix.netcom.com!atlantis From: atlantis@netcom.com (JJ Miranda) Subject: protein folding Message-ID: Organization: ICGNetcom X-Newsreader: TIN [version 1.2 PL2] Date: Sun, 30 Aug 1998 22:45:21 GMT Lines: 9 Sender: atlantis@netcom7.netcom.com Hi all, This is a very subjective question. Which profs at which universities are currently doing the leading work in protein folding? Theoretical or experimental is fine. I just wanted to know what the current opinion in the field was... Sincere regards, JJ Miranda From owner-biophysics@net.bio.net Sun Aug 30 23:00:00 1998 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!howland.erols.net!news1.ispnews.com!c01news01.service.talkway.com!c01read02.service.talkway.com.POSTED!not-for-mail From: "HAMP" Subject: Help in microgravity Newsgroups: bionet.biophysics Followup-To: bionet.biophysics Lines: 14 Message-ID: Date: Mon, 31 Aug 1998 14:16:38 GMT NNTP-Posting-Host: 209.185.64.136 NNTP-Posting-Date: Mon, 31 Aug 1998 07:16:38 PDT Greetings.. and sorry for barging in. I'm working for a competition and have a simple question for such great people like u. If u're given a chance to conduct an experiment in microgravity (or zero gravity), what would u do? Just looking for ideas!!! Remember, the experiment has to sustain itself in a can... with it's own power source. So if there's an idea, just send it to penkar@cyber.net.pk Thanks. The HAMP Surf Usenet at home, on the road, and by email -- always at Talkway. http://www.talkway.com From owner-biophysics@net.bio.net Sun Aug 30 23:00:00 1998 Path: biosci!agate!newsfeed.berkeley.edu!howland.erols.net!frankfurt.de.uu.net!news.uni-stuttgart.de!news.belwue.de!informatik.tu-muenchen.de!lrz-muenchen.de!not-for-mail From: "Peter Böttcher" Newsgroups: bionet.biophysics Subject: FEA: polygons to splines Date: Mon, 31 Aug 1998 16:55:08 +0200 Organization: [posted via] Leibniz-Rechenzentrum, Muenchen (Germany) Lines: 20 Distribution: world Message-ID: <35EAB94C.807334AD@lrz.uni-muenchen.de> NNTP-Posting-Host: 141.84.176.141 Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.03 [de] (Win95; I) Hi! Are there any tools wich convert polygonal models into spline models? Regards, Peter. -- ---------------------------------------------------------------------------------------------------------------- Peter Boettcher Faculty of Veterinary Medicine, Munich, Germany Department of Anatomy I http://www.vetmed.uni-muenchen.de/anat1/home.html Tel: 089/2180-6329 ---------------------------------------------------------------------------------------------------------------- From owner-biophysics@net.bio.net Mon Aug 31 23:00:00 1998 Path: biosci!news.stanford.edu!nntp.cs.ubc.ca!newsfeed.direct.ca!newsfeed1.swip.net!swipnet!newsfeed1.uni2.dk!news.net.uni-c.dk!not-for-mail From: Jan Hansen Newsgroups: bionet.biophysics Subject: 5 Bioinformatics positions offered Date: Tue, 01 Sep 1998 15:50:35 +0200 Organization: Center For Biological Sequence Analysis Lines: 88 Message-ID: <35EBFBAB.66EC92D6@cbs.dtu.dk> NNTP-Posting-Host: e-serine.cbs.dtu.dk Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Trace: news.net.uni-c.dk 904658057 10834 (None) 130.225.67.229 X-Complaints-To: usenet@news.net.uni-c.dk X-Mailer: Mozilla 4.05 [en] (X11; I; IRIX 6.3 IP32) ------------------------------------------------------------------------ Center for Biological Sequence Analysis The Technical University of Denmark ------------------------------------------------------------------------ 5 PhD-stipend and Postdoc positions The center wishes to hire individuals with interest and experience within one or several of the following focus areas: DNA/RNA: * Prokaryotic genes (promoter/operon prediction, integration of predictions). * Construction of DNA Structural Atlases for bacterial and yeast genomes. * Bacterial chromatin. * Computational and experimental analysis of curved DNA. * Whole genome analysis and comparison. * Intron structure and Evolution. * Accelerated evolution in bacteria: molecular mechanisms, evolutionary aspects, and industrial applications. * Expression effects on recombinant genes in non-native hosts. Protein: * Post-translational modification of proteins. * Immunological bioinformatics, including MHC- peptide binding specificities, specificity of proteasome processing, TAP translocation. * Protein structure prediction, including beta-sheet pairing, pair-potentials and distance matrices. * Threading for structure based search for homologous proteins. * Development of new sophisticated neural network and hidden Markov model algorithms for sequence analysis. The center wishes to have the positions filled as soon as possible. The center conducts an active research program in biomolecular sequence and structure analysis with emphasis on novel adaptive computational strategies. CBS was started in 1993 and has recently received a new, substantial five year grant from the Danish National Research Foundation covering the period 1998-2003. Currently the research staff includes 5 associate professors, in addition to assistant professors, PhD-students, database managers, and scientific programmers. The center has excellent computing facilities: an optically connected cluster of 25 O2/Indy SGI workstations, a 12 processor R10000 SGI machine with 2 GB RAM, several other SUN, HP and Apollo workstations, and other resources from the national computer center. For further information on CBS, please consult the WWW pages at www.cbs.dtu.dk. The salary level for PhD stipends in Denmark is appr. $ 37,350 per year in 3 years (incl. pension). For Postdoc positions, depending on your seniority, the salary level ranges from $ 45,950 to $ 52,000 per year in two years (incl. pension). Applicants should send a short application, a curriculum vitae, a complete list of publications, and a statement of research interests to: Center director Soren Brunak, PhD Center for Biological Sequence Analysis Department of Biotechnology, Bld. Tel: +45 45252477 208 Fax: +45 45931585 The Technical University of Denmark Email: brunak@cbs.dtu.dk DK-2800 Lyngby, Denmark WWW: www.cbs.dtu.dk From owner-biophysics@net.bio.net Mon Aug 31 23:00:00 1998 Path: biosci!ihnp4.ucsd.edu!news.scripps.edu!not-for-mail From: David Eliezer Newsgroups: bionet.biophysics Subject: NMR spectroscopist position Date: Tue, 01 Sep 1998 09:30:20 -0700 Organization: The Scripps Research Institute, La Jolla, CA Lines: 32 Message-ID: <35EC211C.46AD83A1@scripps.edu> NNTP-Posting-Host: mime.scripps.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.05 [en] (X11; U; IRIX 6.2 IP22) Research Associate or Assistant Professor position at Cornell University Medical College for an NMR spectroscopist to operate an Institutional biomolecular NMR core facility. Primary responsibilities include active participation in research collaborations with CUMC faculty (including spectrometer operation and data analysis and interpretation), training, scheduling and supervision of users and routine maintenance of the NMR instrumentation. Candidates should have a Ph.D. and post-doctoral experience in biochemistry, biophysics, chemistry, physics, or a related discipline, extensive experience with the day-to-day operation of high field NMR spectrometers, and demonstrated experience with the application of NMR to problems in structural biology. Additional familiarity with NMR methods and software development and/or spectrometer hardware and electronics is a plus. The current facility includes a new 600 MHz four- channel instrument. Send a curriculum vitae, including list of publications, and names of three references to: Fred Maxfield, Ph.D. Department of Biochemistry Cornell University Medical College 1300 York Avenue New York, NY 10021 Fax: 212 746 8875 Salary and rank will be commensurate with experience and qualifications. Cornell University Medical College is an Equal Opportunity/ Affirmative Action Employer.