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Postdoctoral Fellowships in Computational Molecular Biology (Round V)

APPLICATION DEADLINE: FEBRUARY 1, 2000

Catalyzing Career Transitions to Computational Molecular Biology

The Alfred P. Sloan Foundation and the U.S. Department of Energy (Office
of
Health and Environmental Research) announce the fifth round of a
jointly-sponsored postdoctoral research awards program for scientists
interested in computational molecular biology.

This announcement can also be found at http://www.sloan.org under
"Fellowships"

P L E A S E P O S T

The Alfred P. Sloan Foundation and the U.S. Department of Energy believe
that a nexus with exceptional scientific potential is emerging between the
powerful theoretical and practical tools of molecular biology and the
revolutionary power of modern computational techniques. However, too few
scientists possess the cross-disciplinary skills in both molecular biology
and computation that are needed to further such advances.

The purpose of these fellowships is to catalyze career transitions into
computational molecular biology from physics, mathematics, computer
science,
chemistry, engineering and related fields. Ideal candidates will have
strong
educational backgrounds in such fields and wish to bring these backgrounds
to bear upon computational molecular research questions. In exceptional
cases, we will also consider applications from more traditional biological
orientations in transition to computational molecular biology. Applicants
already firmly rooted in computational molecular biology, or who are
proposing to continue pursuit of research undertaken for their Ph.D.s, may
be more appropriate candidates for other postdoctoral opportunities.

This postdoctoral program is designed to give computationally
sophisticated
young scientists an intensive postdoctoral opportunity in an appropriate
molecular biology laboratory. We particularly wish to encourage
applications
from those holding doctorates in mathematics, physics, computer science,
chemistry, engineering or other relevant fields who would like to develop
the capacity to apply their computational sophistication to the complex
problems that increasingly face molecular biology.

The focus is upon computational molecular biology related to data and
information from studies of human and other genomes. Computational
molecular
biology is taken broadly to include the application of mathematics
(continuous and discrete), statistics, probability, and computer science
to
fundamental problems of molecular biology. The goal is to foster
interactions between the mathematical and biological sciences and to
provide
rigorous training for scientists in this new interdisciplinary area. Of
special interest are important problems in structural biology and genome
analysis, including analysis of protein and nucleic acid sequence, protein
and nucleic acid structure, genome structure and maps, cross-species
genome
analysis, multi-genic traits, and structure-function relationships where
the
structures are from genomes, genes, or gene products.

Applications will be reviewed a committee, including Barry Honig, Columbia
University Leroy E. Hood, University of Washington Michael Levitt,
Stanford
University Michael S. Waterman, University of Southern California 

Awards will support up to two years of research work in an appropriate
molecular biology department or laboratory in the U.S. or Canada selected
by
the applicant. The principal selection criteria will be the potential of
the
applicant and the proposed postdoctoral research and training plan for
furthering rigorous computational approaches to analysis of important
molecular biological problems, both theoretical and empirical. The
capabilities of the proposed laboratory and senior scientist in
computational molecular research, and support for the postdoctoral
research
by the senior scientist (department chair or laboratory director) will be
an
important element considered in selection. In addition, where possible,
applicants are encouraged to seek a secondary faculty sponsor from the
mathematical/computer sciences sector of the same campus. Only one
proposal
per applicant will be considered, and a senior scientist should endorse
only
one applicant for this competition.

There are no formal application forms needed for this program. Further
details and application procedures are as follows:

Number, Starting Date and Grant Period:

Up to 10 fellowships will be granted during 2000, each with a total budget
of $100,000 (including indirect and overhead costs, which together will be
limited to 15% of direct costs). These funds are to be spread over a grant
period of two years ($50,000 per year). Selections for this third round
will
be announced in April, 2000. Funding may begin any time after September 1,
2000.

Stipend: 

--$42,000 per year to Fellow, inclusive of benefits.
--$1,500 per year in research expenses to be allocated at the discretion
of
the Fellow.
--Institutional overhead of up to 15% of direct costs.

Eligibility: 

Fellow - Applicants must be citizens or legal permanent residents of the
United States. Ph.D. earned within the past 5 years or expected by June,
2000, in mathematics, physics, computer science, chemistry, engineering or
other relevant fields. (Initiation of postdoc requires completion of
Ph.D.)
Applications to extend an existing postdoc cannot be considered.

Institution - Non-profit private or public institution of higher education
or research, located in the United States or Canada. Applicant must make
formal arrangements with a senior scientist (e.g. laboratory director) at
the institution where the postdoctoral fellowship would be held before
applying for the award.

Materials Needed for Application:

From Applicant (8 copies, fully collated and stapled):

Cover Page, including:

Applicant's name, current address, address for notification in May 2000,
telephone, fax and e-mail -   Applicant's current department and
institution
-   Title of proposed postdoctoral research project and institution at
which
it would be conducted (including mail and email addresses and telephone
and
fax numbers) -   Planned starting date of postdoctoral fellowship -  
Applicant's Ph.D. granting institution and year of receipt (or date
realistically expected) -   Brief educational history indicating the years
and institution(s) of graduate study and of any postdoctoral research -  
Laboratory, department and institution in which postdoctoral fellowship
would be held -   Name, address and telephone of senior scientist -  
Names,
addresses, telephone numbers, etc., of references

Abstract of proposed research (not to exceed 300 words)

Proposed research/training plan describing scientific importance of
subject, with considerable specificity as to analytic methods and data to
be
employed, and reason for choice of proposed sponsoring scientist and
institution (with a firm maximum of 1,500 words, including selected
citations).

If desired, copies of up to two reprints may be attached to each collated
copy of proposal.

Statement of applicant's reasons for interest in computational molecular
biology, current career goals, and potential role of postdoctoral
fellowship
in attaining such goals (ca. 250 words).

A summary of the major findings of the applicant's dissertation research
(250 words).

Curriculum vitae including educational background, topic of doctoral
dissertation, positions held to date, scientific awards and grants
received
citing source, duration and amount (direct costs), full titles, and
references of all publications.

Formal institutional endorsement of proposal may be included, but is not
required unless and until a formal award offer has been made.

A stamped, self-addressed postcard (if applicant desires) to confirm that
application materials have been received (allow at least 3 weeks for
processing; no telephone calls, please).

All applications should be final and complete; no substitutions or
additions.

From Sponsoring Senior Scientist (8 copies, fully collated):

Letter of agreement to host and supervise the research of postdoctoral
applicant, including any necessary institutional clearances, e.g. animal
experimentation, human subjects, recombinant DNA, etc. Letter must include
qualitative comments concerning scientific merit of proposed research and
training plan, and have bold heading "Senior Scientist Letter"

Brief description (500 words) of current research, sources of funding,
relevance of applicant's proposed research, and personnel with whom
applicant would work.

Curriculum vitae including educational background, current and former
positions, scientific awards and grants received citing source, duration
and
amount (direct costs), full titles and references of publications related
to
computational molecular biology.

From References (8 copies):

The applicant must request reference letters from three scientists
(excluding sponsoring scientist) in relevant disciplines who are
knowledgeable about applicant's capabilities and previous research, and to
whom he/she has sent a copy of the research/training plan proposed for the
postdoctoral fellowship. If possible, one of these three should have
personal knowledge of the applicant's doctoral research, and all must
comment on the applicant's summary of the major findings of his/her recent
research.

Reference letters should include comments on overall ranking of applicant,
e.g. top 1% of Ph.D.s, top 10%, etc. and have bold heading "Letter of
Reference". It is the applicant's responsibility to assure that reference
letters (8 copies) are sent.

Deadline and Announcements:

The deadline for receipt of all application materials from applicant,
sponsoring scientist, and related reference letters is February 1, 2000
(firm). Announcements will be made by May 6, 2000.

Send Application To:

Dr. Michael S. Teitelbaum Sloan/DOE Joint Postdoctoral Fellowships  in
Computational Molecular Biology Alfred P. Sloan Foundation 630 Fifth
Avenue,
Suite 2550 New York, NY 10111-0242 http://www.sloan.org 


