From owner-bphyssoc@hgmp.mrc.ac.uk Tue Dec 14 11:10:49 1999 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 11A7E17B78; Tue, 14 Dec 1999 11:10:31 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id 2C53E17B70; Tue, 14 Dec 1999 11:10:28 +0000 (GMT) To: nobody@net.bio.net X-Really-To: bphyssoc@net.bio.net Newsgroups: bionet.prof-society.biophysics From: Dianne@hgmp.mrc.ac.uk, McGavin@hgmp.mrc.ac.uk, DMCGAVIN@biophysics.faseb.org Subject: Symposia and Workshops Schedule Message-Id: <19991214111028.2C53E17B70@mercury.hgmp.mrc.ac.uk> Date: Tue, 14 Dec 1999 11:10:28 +0000 (GMT) Sender: owner-bphyssoc@hgmp.mrc.ac.uk Precedence: bulk Symposia and Workshops Schedule The following Symposia and Workshops are scheduled as follows. Updated information will appear in the Abstract Issue and Annual Meeting Program. Sunday, February 13 8:30 am: Symposium 1 Muscle Crossbridges: Stepping into the Millennium Hugh Huxley, Chair What X-Rays have Shown Us: Then and Now Hugh Huxley, Brandeis University The Millennium Bug and its Crossbridges Michael Reedy, Duke University The Motions of Myosin Heads that Drive Muscle Contraction: Structure-Function Studies on Isolated Fibers Malcolm Irving King*s College, London Conventional and Unconventional Myosins: Variations on a Theme Kathy Trybus, University of Vermont 11:00 am: Symposium 2 Membrane Transport Proteins: Schlepping through the Bilayer H. Ronald Kaback, Organizer Structure of the Fo Sector of the H- Transporting Rotary/ATP Synthase Robert Fillingame University of Wisconsin What to Do While Awaiting Crystals of a Membrane Transport Protein and Thereafter H. Ronald Kaback University of California, Los Angeles Symport by Conformational Change Ernest Wright University of California, Los Angeles 3:45 pm: Symposium 3 Structural Biology in Genomic Analysis Gaetano T. Montelione, Organizer Predicting Targets for Structural Genomics Peer Bork European Molecular Biology Laboratory, Heidelberg X-ray Crystallography and Structural Genomics Stephen Burley The Rockefeller University Protein NMR and Structural Genomics Geatano T. Montelione Rutgers University Structure-based Analysis of Sequence and Function Barry Honig, Columbia University 3:45 pm: Symposium 4 G Protein Signaling: From Receptor to Effector (Sponsored by the CPOW) Heidi E. Hamm, Organizer Structural Origin of Rhodopsin Activation Wayne Hubbell University of California, Los Angeles Insight into G Protein Function and Regulation from Structural Studies Heidi E. Hamm Northwestern University Conformational Control of GTP Hydrolysis by G Proteins Steve Sprang Howard Hughes Medical Institute University of California, San Francisco 5:00 pm: Workshop I Single Molecule Experiments: Revealing the Role of Protein Fluctuations Shimon Weiss, Organizer Single-Molecule Enzymology Sunney Xie, Harvard University Steps, Arrests, and Pauses to Elongation Carlos Bustamante University of California, Berkeley Studying the Action of Single David Bensimon Ecole Normale Superieure Stepping Rotation in a Protein Machine Revealed by Single Molecule Imaging Kazuhiko Kinosita, Keio University The Voltage-sensing Machinery of Potassium Channels Fred Sigworth, Yale University 5:00 pm: Workshop II New Approaches to Measuring and Manipulating Intracellular Messengers Richard H. Kramer, Organizer Local Signaling by IP3 and Ca2+ in Dendrites of Purkinje Neurons Elizabeth A. Finch, Duke University Real-Time Patch-Cram Detection of Cyclic GMP in Intact Cells Richard H. Kramer University of Miami New Molecules for Peeking at or Poking Intracellular Messengers Roger Y. Tsien University of California, San Diego Engineered Channels and Enzymes for Monitoring and Controlling Cell Signaling Hagan Bayley Texas A & M Health Science Center 5:00 pm: Workshop III Closing the Reductionist Loop: Going from Biophysics to Network Dynamics Eve Marder, Organizer Going from the Biophysics of Currents to the Dynamics of Rhythmic Circuits Eve Marder, Brandeis University Modeling Signaling Pathways Ravi Iyengar, Mt. Sinai Medical School Integrative Models of Cardiac Excitation and Arrhythmias Yoram Rudy Case Western Reserve University Dynamics and Neural Codes Gilles Laurent California Institute of Technology Monday, February 14 8:30 am: Symposium 5 Protein Folding: An Urgent Problem in the Postgenomic Era Lila Gierasch, Organizer The Roles of Local Sequence and Global Interactions in the Folding of Predominantly b-sheet Protein Lila Gierasch University of Massachusetts Listening to the Music of Evolution: Folding Theme with Functional Variations Eugene Shakhnovich Harvard University Global and Local Cooperativity in Protein Folding and Function Ernesto Freire The Johns Hopkins University Folding of the Collagen Triple Helix and Misfolding in Disease Jean Baum, Rutgers University 11:00 am: Symposium 6 Membrane Trafficking and Vesicle Fusion Wolfhard Almers, Organizer Kinetic Analysis of Secretory Protein Traffic Jennifer Lippincott-Schwartz National Institutes of Health Insights from Studying Single Exo- and Endocytic Events Wolfhard Almers, Vollum Institute Mechanism of SNARE Proteins in Membrane Fusion Reinhard Jahn Max Planck Institute for Biophysical Chemistry Structural and Functional Insights in the Mechanism of Synaptic Exocytosis Axel Brunger, Yale University 11:00 am: Symposium 7 Folding, Form and Function of RNA and DNA Molecules Anna Marie Pyle, Organizer Active-Site Structure and Catalytic Mechanism of a Large Ribozyme: The Group II Intron Anna Marie Pyle, Columbia University Thermodynamics and the Fast, Error-free Folding of a Large Ribozyme Tobin Sosnick, University of Chicago Structures and Assembly of O. nova Telomeric Protein-ss DNA Complexes Steve Schultz, University of Colorado Structure and Electron Transfer in Synthetic DNA Hairpins Fred Lewis, Northwestern University 3:45 pm: Symposium 8 Public Policy Forum: Science for All Americans in the New Millennium Jonathan King, Organizer Patricia Dehmer, Department of Energy (Other speakers to be announced) Tuesday, February 15 8:30 am: Symposium 9 Phosphatidylinositides in Cell Signaling Donald Hilgemann, Organizer Regulation of Ion Transporters and Channels by Phosphatidylinositides Donald Hilgemann University of Texas, Southwestern Medical Center Visualizing Signaling in the Phosphatidylinositol Pathway Tobias Meyer, Duke University Of FYVEs, Flounders, and Flattened Folds: Structural Biology of Phosphoinositide Signaling James H. Hurley National Institutes of Health Phosphatidylinositol Phosphate Kinases Regulate PtdInsP2-dependent Signaling Christopher L. Carpenter Harvard University 8:30 am: Symposium 10 Molecular Motors: Design and Performance David M. Warshaw, Organizer Myosin Molecular Motors: Design and Performance David M. Warshaw University of Washington The ATP Hydrolysis Cycle of Kinesin and its Coupling to Molecular Force Jonathon Howard University of Washington Structural Mechanisms of Kinesins Robert Fletterick University of California, San Francisco Unconventional Myosins: Structural and Functional Diversity Mark Mooseker, Yale University 11:00 am: Symposium 11 Awards Symposium Distinguished Service Award Helen Berman, Rutgers University Elisabeth Roberts Cole Award Carolyn Cohen, Brandeis University Michael and Kate Bárány Award for Young Investigators Elizabeth Komives University of California, San Diego 3:45 pm: Symposium 12 Transmitter-gated Channel Structure and Function Mark Mayer, Organizer Allosteric Modulation and Pore Block in Ionotropic Glutamate Receptors Mark Mayer National Institutes of Health Biochemical and Crystallograhic Studies of Ionotropic Glutamate Receptors Eric Gouaux, Columbia University Acetylcholine Receptor at 4.6 Ĺ Resolution Nigel Unwin MRC Laboratory of Molecular Biology, Cambridge Gating and Electrostatics in the Acetylcholine Receptor Channel Arthur Karlin, Columbia UniversityWednesday, February 16 8:30 am: Symposium 13 Hybrid Crystallography and Electron Cryomicroscopy: Elucidating Macromolecular Complexes Wah Chiu, Organizer Introduction Wah Chiu Baylor College of Medicine Synergy of X-ray Crystallography and Electron Microscopy for the Structural Biology of Macromolecular Assemblies Stephen Harrison, Harvard University New Twists in Actin Structure and Regulation Revealed by Electron Cryomicroscopy and X-ray Crystallography Amy McGough Baylor College of Medicine High Reslution Model of the Microtubule by Electron Crystallography Eva Nogales University of California, Berkeley The Chemical Basis of Virus Polymorphism Determined by X-ray Crystallography and Electron Cryomicroscopy Jack Johnson The Scripps Research Institute 8:00 am: Symposium 14 Sensational Molecules: Mechanisms of Sensory Transduction Anita L. Zimmerman, Organizer Deactivation Mechanisms of Retinal Rods Marie Burns, Stanford University Transduction and Adaptation in Olfactory Sensory Neurons Anna Menini Istituto di Cibernetica e Biofisica, CNR, Genova Activation of Light Sensitive Channels, TRP and TRPL, in Drosophila Padinjat Raghu Cambridge University Dancing on the Head of a Pin: Motor Proteins in Hair-Cell Adaptation David Corey, Harvard University From owner-bphyssoc@hgmp.mrc.ac.uk Tue Dec 14 11:15:06 1999 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 8A03917B7B; Tue, 14 Dec 1999 11:14:50 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id 58A6317B79; Tue, 14 Dec 1999 11:14:48 +0000 (GMT) To: nobody@net.bio.net X-Really-To: bphyssoc@net.bio.net Newsgroups: bionet.prof-society.biophysics From: Dianne@hgmp.mrc.ac.uk, McGavin@hgmp.mrc.ac.uk, dmcgavin@biophysics.faseb.org Subject: 2000 Annual Meeting Sort Message-Id: <19991214111448.58A6317B79@mercury.hgmp.mrc.ac.uk> Date: Tue, 14 Dec 1999 11:14:48 +0000 (GMT) Sender: owner-bphyssoc@hgmp.mrc.ac.uk Precedence: bulk 2000 Annual Meeting Sort A record 2874 abstracts were programmed for the 2000 Annual Meeting in New Orleans. The Society is indebted to the members who volunteered their time to participate in this year's sort in Bethesda. Steve Siegelbaum, Program Chair James Ames Mordecai Blaustein John Chik Marco Colombini Robert Guy Jan Hoh Robert Horowits Jon Lederer Jim Sellers Nina Sidorova Alasdair Steven Sergei Sukharev W. Gil Wier Leepo Wu Thank you also to those who could not attend, but helped with the sort: Bill Cramer William Clusin Lila Gierasch Ed Gogol Richard Hendler Masai Ikeda-Saito Jonathan King Rocky Kass Manfred Lindau Guy Monteleone Larry Scott Fred Sigworth KathleenTrybus Jian Yang Anita Zimmerman From owner-bphyssoc@hgmp.mrc.ac.uk Fri Dec 17 15:12:28 1999 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 38DCA17ADC; Fri, 17 Dec 1999 15:12:23 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id 327AA17AB0; Fri, 17 Dec 1999 15:12:20 +0000 (GMT) To: nobody@net.bio.net X-Really-To: bphyssoc@net.bio.net Newsgroups: bionet.prof-society.biophysics From: "Dianne McGavin" Subject: CPOW Mentoring Lunch Message-Id: <19991217151220.327AA17AB0@mercury.hgmp.mrc.ac.uk> Date: Fri, 17 Dec 1999 15:12:20 +0000 (GMT) Sender: owner-bphyssoc@hgmp.mrc.ac.uk Precedence: bulk The CPOW will be sponsoring a mentoring lunch for all career levels on Sunday afternoon. Postdoctoral Breakfast The CPOW and MAC are co-sponsoring a postdoctoral breakfast on Tuesday morning. All postdocs are invited. Please come! Ancillary Meetings Each year, the Society's Annual Meeting provides an opportunity for smaller groups to come together. Below are descriptions of two international organizations that will meet this year. Introducing the Korean Biophysical Society The Korean Biophysical Society is only six years old. In 1992, the Biophysical Society of Japan, which had held bilateral biophysics symposia with the Biophysical Society of China, sent a letter to Professor Kim of the Korea Advanced Institute of Science and Technology urging that Korean biophysicists organize a Society and participate in the regional biophysics symposia. At about the same time, Professor J. Tigyi of Hungary, then the Secretary General of the IUPAB, suggested to Professor Kim that the soon-to-be established Korean Biophysical Society apply to become an adhering body of the IUPAB. Thus, the Korean Biophysical Society was launched on June 12, 1993, with the inaugural general meeting and a symposium. Professor Hyoungman Kim was elected first President of the Society. The initial membership of the Society was about 100, mostly in the area of structural biophysics. Soon, biophysicists in other areas, such as eletrophysiology and physics, joined and the membership increased to the current level of 300. The Society holds an annual General Meeting and Symposium in early summer. Although the Society does not publish a scientific journal yet, it promotes communications among members through the semiannual Newsletters. The most important activity of the Society is the East Asian Biophysics Symposium, which is a triennial scientific meeting sponsored by IUPAB as a regional activity. The current President of the Society is Professor Dae-Yong Uhm at Sungkyunkwan University School of Medicine. - Myeong-Hee Yu, Secretary General Korea Research Institute of Bioscience and Biotechnology The Society of Latin American Biophysicists (SOBLA) The Society of Latin American Biophysicists (SOBLA) was created in 1985 during a meeting of the Biophysical Society. The rationale for its creation was several fold: -- To provide a forum for communication between Latin American and Spanish biophysicists; -- To facilitate the education of young Latin American biophysicists; -- To foster the development of Biophysics in Latin America; and -- To recognize the work of outstanding young Latin American Biophysicists. To date the SOBLA is constituted by 645 members working in fifteen countries in the Americas and in five European countries. The main activities of SOBLA includes: -- An annual meeting during the Biophysical Society meeting; -- Publication of two annual Bulletins; -- Organization of an International Scientific meeting every three years; and -- Publication of a Biophysics text in Spanish. - Hector Rasgado-Flores, President From owner-bphyssoc@hgmp.mrc.ac.uk Fri Dec 17 15:14:30 1999 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 1AFDF17AF4; Fri, 17 Dec 1999 15:13:50 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id 361E417ADC; Fri, 17 Dec 1999 15:13:41 +0000 (GMT) To: nobody@net.bio.net X-Really-To: bphyssoc@net.bio.net Newsgroups: bionet.prof-society.biophysics From: "Dianne McGavin" Subject: 2000 Annual Meeting Events Message-Id: <19991217151341.361E417ADC@mercury.hgmp.mrc.ac.uk> Date: Fri, 17 Dec 1999 15:13:41 +0000 (GMT) Sender: owner-bphyssoc@hgmp.mrc.ac.uk Precedence: bulk The CPOW will be sponsoring a mentoring lunch for all career levels on Sunday afternoon. Postdoctoral Breakfast The CPOW and MAC are co-sponsoring a postdoctoral breakfast on Tuesday morning. All postdocs are invited. Please come! Ancillary Meetings Each year, the Society's Annual Meeting provides an opportunity for smaller groups to come together. Below are descriptions of two international organizations that will meet this year. Introducing the Korean Biophysical Society The Korean Biophysical Society is only six years old. In 1992, the Biophysical Society of Japan, which had held bilateral biophysics symposia with the Biophysical Society of China, sent a letter to Professor Kim of the Korea Advanced Institute of Science and Technology urging that Korean biophysicists organize a Society and participate in the regional biophysics symposia. At about the same time, Professor J. Tigyi of Hungary, then the Secretary General of the IUPAB, suggested to Professor Kim that the soon-to-be established Korean Biophysical Society apply to become an adhering body of the IUPAB. Thus, the Korean Biophysical Society was launched on June 12, 1993, with the inaugural general meeting and a symposium. Professor Hyoungman Kim was elected first President of the Society. The initial membership of the Society was about 100, mostly in the area of structural biophysics. Soon, biophysicists in other areas, such as eletrophysiology and physics, joined and the membership increased to the current level of 300. The Society holds an annual General Meeting and Symposium in early summer. Although the Society does not publish a scientific journal yet, it promotes communications among members through the semiannual Newsletters. The most important activity of the Society is the East Asian Biophysics Symposium, which is a triennial scientific meeting sponsored by IUPAB as a regional activity. The current President of the Society is Professor Dae-Yong Uhm at Sungkyunkwan University School of Medicine. - Myeong-Hee Yu, Secretary General Korea Research Institute of Bioscience and Biotechnology The Society of Latin American Biophysicists (SOBLA) The Society of Latin American Biophysicists (SOBLA) was created in 1985 during a meeting of the Biophysical Society. The rationale for its creation was several fold: -- To provide a forum for communication between Latin American and Spanish biophysicists; -- To facilitate the education of young Latin American biophysicists; -- To foster the development of Biophysics in Latin America; and -- To recognize the work of outstanding young Latin American Biophysicists. To date the SOBLA is constituted by 645 members working in fifteen countries in the Americas and in five European countries. The main activities of SOBLA includes: -- An annual meeting during the Biophysical Society meeting; -- Publication of two annual Bulletins; -- Organization of an International Scientific meeting every three years; and -- Publication of a Biophysics text in Spanish. - Hector Rasgado-Flores, President From owner-bphyssoc@hgmp.mrc.ac.uk Thu Dec 23 14:41:10 1999 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 6BC8D17A71; Thu, 23 Dec 1999 14:41:06 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id DDF6017A59; Thu, 23 Dec 1999 14:41:04 +0000 (GMT) To: nobody@net.bio.net X-Really-To: bphyssoc@net.bio.net Newsgroups: bionet.prof-society.biophysics From: "Dianne McGavin" Subject: Bioenergetics Subgroup Message-Id: <19991223144104.DDF6017A59@mercury.hgmp.mrc.ac.uk> Date: Thu, 23 Dec 1999 14:41:04 +0000 (GMT) Sender: owner-bphyssoc@hgmp.mrc.ac.uk Precedence: bulk The Bioenergetics Subgroup Program Structural Analysis of Membrane Proteins: Realizing the Mitochondrion*s Potential will be held at the New Orleans Convention Center Saturday, February 12, 2000. Session I: Electron transport: Three- dimensional structural determination of cytochrome bc1 and cytochrome b6f complexes Edward A. Berry, Organizer and Co-chair Lawrence Berkeley National Laboratory Chang-An Yu, Co-chair Oklahoma State University 8:30 am Chang-An Yu Correlation Between Intramolecular Electron Transfer Rates and Structural Data of Cytochrome bc1 Complex 9:00 am Edward A. Berry Quinone Binding Sites in the Avian Cytochrome bc1 Complex 9:30 am So Iwata, Uppsala University Uppsala, Sweden Rieske FeS Protein Motion in the Bovine Cytochrome bc1 Complex 10:00 am Carola Hunte, MPI- Biophysik Frankfurt, Germany To be announced - On the Structure of Fungal bc1 Complex 10:30 am Cecile Breyton, MPI- Biophysik Frankfurt, Germany Structural Analysis of the Cytochrome b6f Complex by Electron Crystallography 11:00 am William A. Cramer Purdue University Unique structure-function aspects of the cytochrome b6f complex. Discussion: 11:30 - 11:40 Session II: Presentation of Annual Young Investigator Awards Lunch Session III: Structural and Functional Studies of Mitochondrial Transporters Ronald S. Kaplan FUHS/The Chicago Medical School Maureen W. McEnery (co-chairs) Case Western Reserve University School of Medicine Speakers 1:00 pm Martin Klingenberg, University of Munich, Germany The Mitochondrial Carrier Family* a Special Breed 1:45 pm John E. Walker, Medical Research Council, Cambridge Identification and Functions of New Transporters in Mitochondria 2:30 pm Hartmut Wohlrab, Boston Biomedical Research Institute and Harvard Medical School Phosphate Transport Across the Inner Mitochondrial Membrane. How Does PTP Do It? 3:15 pm Ronald S. Kaplan, FUHS/The Chicago Medical School Structure/Function Relationships Within the Mitochondrial Citrate Transport Protein 4:00 pm Theo Wallimann, Institute for Cell Biology, ETH Hönggerberg, Zurich, Switzerland Involvement of Mitochondrial Creatine Kinase in Energy Channeling and Permeability Transition: Explanations for the Neuroprotective Actions of Creatine Discussion: 4:45 to 5:00 pm Session IV: Roundtable Discussion. Lessons From the Solved Structures of Integral Membrane Proteins: Methodology and Structural Principles (Speakers from both symposia will be asked to participate.) John E. Walker, Chair Medical Research Council, Cambridge Bioenergetics Subgroup Annual Dinner and Business Meeting Bioenergetics Subgroup Dinner will take place at Olivier's Creole Restaurant, 204 Decatur Street, New Orleans (504-525-7734), Saturday, February 12, 2000, 7:30 cash bar, 8:00 dinner with house wine (see menu listed on the BESG website http://physiology.cwru.edu/~besg/). The price will be $34 for reservation received before Friday, February 4 (reservations received after that date will be charged an extra 15% in accordance with restaurant policies). Please send check, payable to The Biophysical Society (Bioenergetics Dinner) to: Carmen Mannella New York State Department of Health Wadsworth Center Empire State Plaza, Box 509 Albany, NY 12201-0509 tel (518) 474-2462 fax (518) 486-4901 email: cam14@health.state.ny.us From owner-bphyssoc@hgmp.mrc.ac.uk Mon Dec 27 19:51:33 1999 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id D5C6517A74; Mon, 27 Dec 1999 19:51:28 +0000 (GMT) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 1) id B030817A56; Mon, 27 Dec 1999 19:51:27 +0000 (GMT) To: nobody@net.bio.net X-Really-To: bphyssoc@net.bio.net Newsgroups: bionet.prof-society.biophysics From: "Dianne McGavin" Subject: Public Affairs Updates Message-Id: <19991227195127.B030817A56@mercury.hgmp.mrc.ac.uk> Date: Mon, 27 Dec 1999 19:51:27 +0000 (GMT) Sender: owner-bphyssoc@hgmp.mrc.ac.uk Precedence: bulk Boundaries Panel Update NIH's Panel on Scientific Boudaries for Review met on November 8-9 to consider comments received from the scientific community to its Phase 1 draft report. Three Integrated Review Groups (IRGs) were added to the 21 proposed in the Phase 1 report. They are: 1) Biology of Development and Aging 2) Renal and Urological Sciences 3) AIDS and AIDS-related Research The panel plans to conduct conference calls with "experts in specific areas.....to refine the recommendations in the Phase 1 report." The Panel's Phase 2 activities will begin in early 2000, when it will establish panels composed of NIH staff and relevant members of extramural communities. These panels will design study sections for some of the newly recommended IRGs. Plans include for additional panels to be commissioned in 2001 to complete Phase 2. Call for NSF Stories The Public Affairs Committee is gathering information to help explain to Congress and the public the impact that NSF-funded research has made on biomedical research. Do you have a personal vignette or story about an advancement made from research that was funded by the NSF? Send it to society@biophysics.faseb.org. Barkley Visit with Tubbs Jones Biophysical Society representative to the FASEB Board, Mary Barkley, visited her Congresswoman Stephanie Tubbs Jones (D-OH) on Capitol Hill while in town for the FASEB board meeting. Jones, a first-term Representative, asked many questions regarding NIH activities. During a lengthy and animated discussion, Barkley was able to acquaint Jones with some of the issues and concerns shared by primary investigators in laboratories throughout the country, while Jones shared her own difficulties in often having to choose between important and worthy programs. In discussing both NIH and NSF funding, Congresswoman Tubbs Jones was encouraging about the prospects for strong support of science among her colleagues.