From owner-cardiovascular@net.bio.net Fri Jul 02 22:40:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!cyclone.bc.net!unixg.ubc.ca!news.vcn.bc.ca!not-for-mail From: Doug Skrecky Newsgroups: misc.fitness.weights,bionet.biology.cardiovascular Subject: glutamine prevents heart damage Date: 2 Jul 1999 23:32:13 GMT Organization: Vancouver CommunityNet Lines: 33 Message-ID: <7lji5t$21s$1@sylvester.vcn.bc.ca> NNTP-Posting-Host: vcn.bc.ca X-Trace: sylvester.vcn.bc.ca 930958333 2108 207.102.64.2 (2 Jul 1999 23:32:13 GMT) X-Complaints-To: sys-admin@vcn.bc.ca NNTP-Posting-Date: 2 Jul 1999 23:32:13 GMT User-Agent: tin/pre-1.4-19990517 ("Psychonaut") (UNIX) (SunOS/5.6 (sun4u)) Authors Khogali SE. Harper AA. Lyall JA. Rennie MJ. Institution Department of Anatomy & Physiology, University of Dundee, Scotland, UK. Title Effects of L-glutamine on post-ischaemic cardiac function: protection and rescue. Source Journal of Molecular & Cellular Cardiology. 30(4):819-27, 1998 Apr. Abstract We investigated the effects of L-glutamine (0-20 mM) on cardiac function. The isolated perfused working rat heart (left atrial and aortic pressures of 5 and 70 cm H2O, respectively) was subjected to 20 min of normothermic low-flow ischaemia followed by reperfusion for 35 min. In the absence of glutamine, ischaemia-reperfusion caused an immediate significant (P < 0.01) fall in cardiac output from 46 to 20 ml/min, with a further deterioration to 17 ml/min at 35 min reperfusion. Ischaemia also caused a significant (P < 0.05) fall in myocardial glutamate from 2.6 to 1.8 mumol/g wet weight; and ischaemia-reperfusion caused significant (each P < 0.05) diminutions of myocardial ATP from 3.5 to 1.0 mumol/g wet weight and phosphocreatine from 4.8 to 1.5 mumol/g wet weight and resulted in significant (P < 0.05) accumulation of myocardial lactate from 0.9 to 4.3 mumol/g wet weight. Glutamine, present throughout the perfusion protocol (i.e. prior to ischaemia), at or above 1.25 mM, prevented the post-ischaemic diminution of cardiac output and the deleterious changes in myocardial metabolites. Post-ischaemic treatment with glutamine at 2.5 mM completely prevented the post-ischaemic diminution of cardiac output and restored the myocardial metabolites to normal. CONCLUSIONS: Glutamine may be suitable as a cardioprotective and rescue agent. These effects may be mediated by maintenance of myocardial glutamate, ATP and phosphocreatine: and prevention of lactate accumulation. From owner-cardiovascular@net.bio.net Tue Jul 06 15:39:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!news-peer1.sprintlink.net!news-backup-west.sprintlink.net!news.sprintlink.net!rpi!vcmr-13.rcs.rpi.edu!pillah From: Hari Pillai Newsgroups: bionet.biology.cardiovascular Subject: Culturing Chicks *WITHOUT* Yolk? Date: Tue, 6 Jul 1999 12:21:36 -0400 Organization: Rensselaer Polytechnic Institute, Troy NY, USA Lines: 30 Message-ID: Reply-To: Hari Pillai NNTP-Posting-Host: vcmr-13.rcs.rpi.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Sender: pillah@vcmr-13.rcs.rpi.edu ---------- Forwarded message ---------- Date: Tue, 6 Jul 1999 12:19:30 -0400 From: Hari Pillai Newsgroups: sci.agriculture.poultry Subject: Culturing Chicks *WITHOUT* Yolk? Hello: I would like to acquire images of the 2 or 3 day old chick embryo in the egg. However, the yolk and albumen are very translucent. Therefore, I'd like to culture the chick egg in some kind of medium that will allow its growth/angiogenesis from days 3-11. I am very familiar with the "shell-less" technique (Auerbach and Dunn et al), which can sustain the chicks' development up till it's time to hatch with a high success rate (~45% and %90% respectively). However, these techniques still involve leaving the yolk/albumen in, both of which could obfuscate my view of the developing vessels. Please direct me to good researchers/literature where I can read about how to culture chick eggs without the yolk. Regards, Hari Pillai From owner-cardiovascular@net.bio.net Wed Jul 07 00:59:00 1999 Path: biosci!PRISMA.IT!jey46 From: jey46@PRISMA.IT Newsgroups: bionet.biology.cardiovascular Subject: Cable TV information .......IMPORTANT FYI Date: 6 Jul 1999 18:59:04 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 78 Sender: daemon@net.bio.net Distribution: world Message-ID: <199907063068QAA42205@totalcoolness.gr> NNTP-Posting-Host: net.bio.net ENHANCE Your Cable TV! EASY to assemble plans for only $12.00 ! GET THE MOST out of your cable TV by using this SIMPLE "Fine Tuning" device! YOU WILL HAVE GREAT RESULTS! YOU will be enjoying enhanced cable viewing in just a few days! 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TO REMOVE CLICK ON mailto:merchyou@nfmail.com?subject=remove ** 40700 From owner-cardiovascular@net.bio.net Thu Jul 08 06:26:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!newsfeed.berkeley.edu!cyclone.bc.net!unixg.ubc.ca!news.vcn.bc.ca!not-for-mail From: Doug Skrecky Newsgroups: bionet.biology.cardiovascular,sci.life-extension Subject: arginine much better than lovastatin Date: 8 Jul 1999 07:18:25 GMT Organization: Vancouver CommunityNet Lines: 45 Message-ID: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> NNTP-Posting-Host: vcn.bc.ca X-Trace: sylvester.vcn.bc.ca 931418305 19262 207.102.64.2 (8 Jul 1999 07:18:25 GMT) X-Complaints-To: sys-admin@vcn.bc.ca NNTP-Posting-Date: 8 Jul 1999 07:18:25 GMT User-Agent: tin/pre-1.4-19990517 ("Psychonaut") (UNIX) (SunOS/5.6 (sun4u)) Authors Boger RH. Bode-Boger SM. Brandes RP. Phivthong-ngam L. Bohme M. Nafe R. Mugge A. Frolich JC. Institution Institute of Clinical Pharmacology, Medical School, Hannover, Germany. Title Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin. Source Circulation. 96(4):1282-90, 1997 Aug 19. Abstract BACKGROUND: We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND RESULTS: Rabbits were fed 1% cholesterol for 4 weeks and 0.5% cholesterol for an additional 12 weeks. Two groups of cholesterol-fed rabbits were treated with L-arginine (2.0% in drinking water) or lovastatin (10 mg/d) during weeks 5 through 16. Systemic nitric oxide (NO) formation was assessed as the urinary excretion rates of nitrate and cGMP in weekly intervals. Cholesterol feeding progressively reduced urinary nitrate excretion to approximately 40% of baseline (P<.05) and increased plasma concentrations of asymmetrical dimethylarginine (ADMA), an endogenous NO synthesis inhibitor. Dietary L-arginine reversed the reduction in plasma L-arginine/ADMA ratio and partly restored urinary excretion of nitrate and cGMP (each P<.05 vs cholesterol) but did not change plasma cholesterol levels. L-Arginine completely blocked the progression of carotid intimal plaques, reduced aortic intimal thickening, and preserved endothelium-dependent vasodilator function. Lovastatin treatment reduced plasma cholesterol by 32% but did not improve urinary nitrate or cGMP excretion or endothelium-dependent vasodilation. Lovastatin had a weaker inhibitory effect on carotid plaque formation and aortic intimal thickening than L-arginine. L-Arginine inhibited but lovastatin potentiated superoxide radical generation in the atherosclerotic vascular wall. CONCLUSIONS: Dietary L-arginine improves NO-dependent vasodilator function in cholesterol-fed rabbits and completely blocks the progression of plaques via restoration of NO synthase substrate availability and reduction of vascular oxidative stress. Lovastatin treatment has a weaker inhibitory effect on the progression of atherosclerosis and no effect on vascular NO elaboration, which may be due to its stimulatory effect on vascular superoxide radical generation. From owner-cardiovascular@net.bio.net Fri Jul 09 03:41:00 1999 Path: biosci!newshost.lanl.gov!awabi.library.ucla.edu!142.231.112.2!cyclone.bc.net!unixg.ubc.ca!news.vcn.bc.ca!not-for-mail From: Doug Skrecky Newsgroups: bionet.biology.cardiovascular,sci.life-extension Subject: Re: arginine much better than lovastatin Date: 9 Jul 1999 04:33:20 GMT Organization: Vancouver CommunityNet Lines: 36 Message-ID: <7m3u2g$731$2@sylvester.vcn.bc.ca> References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> NNTP-Posting-Host: vcn.bc.ca X-Trace: sylvester.vcn.bc.ca 931494800 7265 207.102.64.2 (9 Jul 1999 04:33:20 GMT) X-Complaints-To: sys-admin@vcn.bc.ca NNTP-Posting-Date: 9 Jul 1999 04:33:20 GMT User-Agent: tin/pre-1.4-19990517 ("Psychonaut") (UNIX) (SunOS/5.6 (sun4u)) lowcarb@maelstrom.stjohns.edu Todd Moody wrote: > Hey, thanks for this one; it's an addition to my "nut files." > Some of you may remember that a while back I posted some > abstracts to studies that showed that the arginine:lysine ratio > of a protein has an effect on serum lipids, with a high ratio > promoting a favorable effect. Of all foods that I checked, nut > proteins tended to have the highest arg:lys ratio. The study > that you have posted here suggests that arginine alone has a > protective effect, perhaps independent of blood lipids. The > Adventist study showed a strong inverse relationship between nut > consumption and CHD (including the non-nut peanut); perhaps the > arginine content is the reason why. > Arginine's effect on NO has impressed some of the scientists who did research on the effect of nuts on cardiovascular disease. It is currently the main theory that accounts for the benefits of nuts. (nut fat is the second) It is hard to go wrong eating a lot of nuts on a low carb diet. Eating nuts is even associated with (slightly) reduced body weight in the bargain. IMHO, the main objection to a low carb diet from main stream medicine is about how it is implimented. Eating a lot of meat with all that saturated fat not trimmed off looks to be a major reason why meat eating is associated with increased mortality rates. Even eggs look like they may be helpful, provided it is only egg white that is consumed. In a recent test egg white was found to dramatically lower bad cholesterol, and at the same time increase the good (HDL) cholesterol. This is a rare feat, as few dietary alterations have been found to raise HDL. Lean meat, nuts, tofu, egg whites, and lots of blood pressure lowering extra virgin olive oil on your veggies looks to be a hard combo to beat. Some doctors might still complain that a high protein diet increases the risk of kidney damage. However only meat protein is associated with kidney stress. Other sources of protein, including egg whites appear not to bother kidneys. From owner-cardiovascular@net.bio.net Sat Jul 10 17:35:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!newsfeed.berkeley.edu!su-news-hub1.bbnplanet.com!washdc3-snh1.gtei.net!news.gtei.net!dfiatx1-snr1.gtei.net.POSTED!not-for-mail From: "Casey Jones" Newsgroups: bionet.biology.cardiovascular Subject: Dr. Henry Bieler's theories about cholesterol Lines: 13 X-Newsreader: Microsoft Outlook Express 4.71.1712.3 X-MimeOLE: Produced By Microsoft MimeOLE V4.71.1712.3 Message-ID: X-Trace: /wmC6B16pE7QagoG/BsvHTqjiNH8jFvZZeRPV9hNMdSOo0Ggyla84iyYGmDU20pJtb6S21te9FRU!GHb1u6cVLitomyxhtpJqnVxnfs+FpoddUe9NnQhRoi02AYSOcRdZz+FNM/E1zLwHO0u9nZw= X-Complaints-To: abuse@gte.net X-Abuse-Info: Please be sure to forward a copy of ALL headers X-Abuse-Info: Otherwise we will be unable to process your complaint properly NNTP-Posting-Date: Sat, 10 Jul 1999 18:29:43 GMT Distribution: world Date: Sat, 10 Jul 1999 18:29:43 GMT In a book published in 1965 called Food Is Your Best Medicine, nutritionist and physician Henry Bieler makes the claim that consuming cholesterol in an uncooked state does not raise cholesterol levels. For example, he makes the claim that eating uncooked butter or uncooked egg yolks does not raise cholesterol levels in the blood. He points the finger of blame for clogged arteries at the consumption of cooked cholesterol, hydrogenated oils, and oils cooked with starches. This would seem, in part, to contradict current medical thinking on the subject. Does anyone know of any studies that either support or discredit Dr. Bieler's theories with respect to cholesterol? From owner-cardiovascular@net.bio.net Sun Jul 11 05:51:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!newsfeed.berkeley.edu!newspeer.monmouth.com!dispose.news.demon.net!demon!colt.net!news.tvd.be!feeder.nmix.net!198.59.136.4.MISMATCH!feeder.swcp.com!sloth.swcp.com!llama.swcp.com!not-for-mail From: lewitt@swcp.com (Martin E. Lewitt) Newsgroups: bionet.biology.cardiovascular,sci.life-extension Subject: Re: arginine much better than lovastatin Date: 11 Jul 1999 00:23:43 -0600 Organization: Lewitt family, Sandia Park, NM Message-ID: <7m9d9f$jnl@llama.swcp.com> References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> <7m3u2g$731$2@sylvester.vcn.bc.ca> NNTP-Posting-Host: llama.swcp.com Lines: 71 In article <7m3u2g$731$2@sylvester.vcn.bc.ca>, Doug Skrecky wrote: > IMHO, the main objection to a low carb diet from main stream medicine >is about how it is implimented. Eating a lot of meat with all that >saturated fat not trimmed off looks to be a major reason why meat eating >is associated with increased mortality rates. Meat doesn't have that much saturated fat. About half is mono-unsaturated. There is no reason to supplement with olive oil if you are eating plenty of meat. However, substituting olive oil for transfatty acids might be of some benefit. On an isocaloric basis do you have a good reason to prefer sugar (i.e. non-fibre carbohydrates) to saturated fat? I suspect that meat is associated with increased mortality rates for one (or both) of two reasons, meat is also associated with high calorie diets and red meat is associated with high iron diets. There does appear to be some weak statistical evidence against one of the saturated fatty acids (I forget which one), but I am suspiscious, on principle to the idea that our bodies would choose a method of calorie storage that wasn't fairly inert and benign. >Even eggs look like they >may be helpful, provided it is only egg white that is consumed. In a >recent test egg white was found to dramatically lower bad cholesterol, and >at the same time increase the good (HDL) cholesterol. This is a rare feat, >as few dietary alterations have been found to raise HDL. > Lean meat, nuts, tofu, egg whites, and lots of blood pressure lowering >extra virgin olive oil on your veggies looks to be a hard combo to beat. >Some doctors might still complain that a high protein diet increases the >risk of kidney damage. However only meat protein is associated with kidney >stress. Other sources of protein, including egg whites appear not to >bother kidneys. Do you have a cite for this association of meat protein with kidney stress. I was particularly interested in this since I am on a low carb diet and have only one kidney, but I couldn't find any evidence of damage to the normal kidney, only that restriction is of benefit in end stage kidney disease. Something that differentiates between protein types might be closer to shedding light on some possible mechanism for damaging the "normal" kidney. You've got 4 organic categories of macro-nutrients, what order would you put them in on the toxicity scale, from lowest to highest? Here is my order: 1) fibre basically inert 2) fat saturated fat is relatively inert pure calories some unsaturated fats are beneficial and essential nutrients transfatty acids and some unsaturated fatty acids have some toxicty 3) protein essential nutrients, essential to maintainance of PH balance by kidney increases nitrogen load on kidneys 4) non-fibre carbs no nutritional value other than calories, though some high carb foods are good sources of vitamin C liver has limited capacity to process fructose, associated with high fasting TG levels and high uric acid levels (gout and some kidney stones) glucose is associated with high fasting TG, hyperinsulinism (syndrome X, etc), interconversion to toxic sorbitol, glycation of proteins, etc. -- Martin -- Personal, not work info: Martin E. Lewitt My opinions are Domain: lewitt@swcp.com P.O. Box 729 my own, not my Hm phone: (505) 281-3248 Sandia Park, NM 87047-0729 employer's. From owner-cardiovascular@net.bio.net Sun Jul 11 07:34:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!newsfeed.berkeley.edu!cyclone.news.idirect.com!island.idirect.com!tor-nx1.netcom.ca!tor-nn1.netcom.ca.POSTED!not-for-mail From: "David Lloyd-Jones" Newsgroups: bionet.biology.cardiovascular,sci.life-extension References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> <7m3u2g$731$2@sylvester.vcn.bc.ca> <7m9d9f$jnl@llama.swcp.com> Subject: Re: arginine much better than lovastatin Lines: 52 X-Priority: 3 X-MSMail-Priority: Normal X-Newsreader: Microsoft Outlook Express 5.00.2314.1300 X-MimeOLE: Produced By Microsoft MimeOLE V5.00.2314.1300 Message-ID: Date: Sun, 11 Jul 1999 04:29:23 -0400 NNTP-Posting-Host: 207.181.81.9 X-Complaints-To: abuse@netcom.ca X-Trace: tor-nn1.netcom.ca 931681691 207.181.81.9 (Sun, 11 Jul 1999 04:28:11 EDT) NNTP-Posting-Date: Sun, 11 Jul 1999 04:28:11 EDT Organization: Netcom Canada Martin E. Lewitt wrote > > I suspect that meat is associated with increased mortality rates for > one (or both) of two reasons, meat is also associated with high calorie > diets and red meat is associated with high iron diets. That's a plausible and attractive theory. But if it's true it still leaves the problem of how to eat red meat without getting the iron and the calories. Any evidence on the proposition? How would you separate the iron and calorie effects from the satfat ones? Has anybody done this? > You've got 4 organic categories of macro-nutrients, what order would you put > them in on the toxicity scale, from lowest to highest? Here is > my order: > > 1) fibre > basically inert > 2) fat > saturated fat is relatively inert pure calories > some unsaturated fats are beneficial and essential nutrients > transfatty acids and some unsaturated fatty acids have some toxicty > 3) protein > essential nutrients, essential to maintainance of PH balance by > kidney > increases nitrogen load on kidneys > 4) non-fibre carbs > no nutritional value other than calories, though some high carb > foods are good sources of vitamin C > liver has limited capacity to process fructose, associated with > high fasting TG levels and high uric acid levels (gout and > some kidney stones) > glucose is associated with high fasting TG, > hyperinsulinism (syndrome X, etc), interconversion to toxic > sorbitol, glycation of proteins, etc. I think this last is plausible only in a thoroughly reductive sense. If those components were what we ate, then that might be the way we'd list them in order. Both protein and "non-fibre carbs", however, are utterly artificial categories once you step inside a kitchen. Meat, eggs, beans, pulses and tofu are all different from each other in the ways they fit into our diets, and fruits and vegetables act out their important roles not only through their burnables but through their tens of thousands of builders and constructors. -dlj. From owner-cardiovascular@net.bio.net Sun Jul 11 08:42:00 1999 Path: biosci!newshost.lanl.gov!arclight.uoregon.edu!hammer.uoregon.edu!newsfeed.direct.ca!tor-nx1.netcom.ca!tor-nn1.netcom.ca.POSTED!not-for-mail From: "David Lloyd-Jones" Newsgroups: bionet.biology.cardiovascular,sci.life-extension References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> <7m3u2g$731$2@sylvester.vcn.bc.ca> <7m9d9f$jnl@llama.swcp.com> Subject: Re: arginine much better than lovastatin Lines: 15 X-Priority: 3 X-MSMail-Priority: Normal X-Newsreader: Microsoft Outlook Express 5.00.2314.1300 X-MimeOLE: Produced By Microsoft MimeOLE V5.00.2314.1300 Message-ID: Date: Sun, 11 Jul 1999 05:37:29 -0400 NNTP-Posting-Host: 207.181.81.9 X-Complaints-To: abuse@netcom.ca X-Trace: tor-nn1.netcom.ca 931685780 207.181.81.9 (Sun, 11 Jul 1999 05:36:20 EDT) NNTP-Posting-Date: Sun, 11 Jul 1999 05:36:20 EDT Organization: Netcom Canada David Lloyd-Jones wrote > and fruits and vegetables act out their important roles not only > through their burnables but through their tens of thousands of builders and > constructors. Should be "builders and regulators." -dlj. From owner-cardiovascular@net.bio.net Sun Jul 11 15:21:00 1999 Path: biosci!rutgers!gatech!howland.erols.net!news.megsinet.net.MISMATCH!news.corecomm.net!not-for-mail From: another_better_way@hotmail.com Newsgroups: bionet.biology.cardiovascular Subject: ACAD for Linux ... Message-ID: <107111999115143sforge@mcs.net> Lines: 14 Date: Sat,10 Jul 1999 19:21:33+2000 NNTP-Posting-Host: 216.214.39.146 X-Trace: news.corecomm.net 931709381 216.214.39.146 (Sun, 11 Jul 1999 11:09:41 CDT) NNTP-Posting-Date: Sun, 11 Jul 1999 11:09:41 CDT Look at this web page to learn more about ACAD for Linux !!! http://209.218.86.64/linux.html If you know someone who can be interested in that please tell him or her about this web page. Thank you for your time. From owner-cardiovascular@net.bio.net Sun Jul 11 18:46:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!feed1.news.rcn.net!rcn!not-for-mail From: Doug & Rebecca Newsgroups: bionet.biology.cardiovascular Subject: New Cardiovascular Site Date: Sun, 11 Jul 1999 14:49:02 +0000 Lines: 34 Message-ID: <3788AEDE.E48@erols.com> Reply-To: dougandbeck@erols.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Trace: RVli3SHnEtv1pjDorFDHRpBkXCyWJ4FlWcorQH99yG4= X-Complaints-To: abuse@rcn.com NNTP-Posting-Date: 11 Jul 1999 19:40:03 GMT X-Mailer: Mozilla 3.01C-KC032698 (Win95; I) http://www.cardiovascular.cx is the new online home of "The Physiology of the Cardiovascular System," a global analysis of the gross mechanical function of the cardiovascular system -- including the oft-misunderstood factors governing cardiac output -- written by the former Associate Dean of the University of Arizona College of Medicine base on his more than 30 years of cardiac surgery, research, and experimentation. I've enclosed the text of the site summary below, to allow you to see if it fits your interests. _________________________ SUMMARY The significance of the ten unique characteristics of the cardiovascular system has been demonstrated by clinical observations, cardio-bypass data, animal mechanical heart replacement experiments, and a simulated cardiovascular model. All of the evidence validates that: 1. The cardiovascular system is a circle containing a mean-cardiovascular pressure dependent upon volume and compliance. 2. The heart is a passively filling pump. 3. Atria increase cardiac output by causing continuous venous flow to the intermittently contracting ventricles, not by pumping up the ventricles. 4. Circulation rate is normally determined by the extra-cardiac factors: mean-cardiovascular pressure and inlet impedance. 5.It is only during heart failure that the heart is the regulator of cardiac output. (from http://www.cardiovascular.cx) From owner-cardiovascular@net.bio.net Sun Jul 11 20:30:00 1999 Path: biosci!newshost.lanl.gov!logbridge.uoregon.edu!news.maxwell.syr.edu!tor-nx1.netcom.ca!tor-nn1.netcom.ca.POSTED!not-for-mail Message-ID: <37890AB1.2F67@netcom.ca> From: Tom Matthews Reply-To: tmatth@netcom.ca Organization: Health & Longevity Unlimited X-Mailer: Mozilla 3.01Gold (Win95; I) MIME-Version: 1.0 Newsgroups: bionet.biology.cardiovascular,sci.life-extension Subject: Re: arginine much better than lovastatin References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> <7m3u2g$731$2@sylvester.vcn.bc.ca> <7m9d9f$jnl@llama.swcp.com> Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Lines: 91 Date: Sun, 11 Jul 1999 17:20:49 -0400 NNTP-Posting-Host: 216.123.38.4 X-Complaints-To: abuse@netcom.ca X-Trace: tor-nn1.netcom.ca 931728289 216.123.38.4 (Sun, 11 Jul 1999 17:24:49 EDT) NNTP-Posting-Date: Sun, 11 Jul 1999 17:24:49 EDT Martin E. Lewitt wrote: > I suspect that meat is associated with increased mortality rates for > one (or both) of two reasons, meat is also associated with high calorie > diets and red meat is associated with high iron diets. Another major reason, IMO, is that meat is mostly browned when cooked and this high temperature produced many carcinogenic compounds. > There does appear > to be some weak statistical evidence against one of the saturated > fatty acids (I forget which one), but I am suspiscious, on principle to > the idea that our bodies would choose a method of calorie storage that > wasn't fairly inert and benign. There is clear evidence for palmitic acid (C:16) causing a 'bad' cholesterol profile. Also ruminant contain the natural trans fat elaidic acid (C:18:1;9). > You've got 4 organic categories of macro-nutrients, what order would you put > them in on the toxicity scale, from lowest to highest? Here is > my order: > > 1) fibre > basically inert OTOH, in excess they can cause deficiencies of minerals, EFAs and fat soluble vitamins. > 2) fat > saturated fat is relatively inert pure calories > some unsaturated fats are beneficial and essential nutrients > transfatty acids and some unsaturated fatty acids have some toxicty Some saturated fats are clearly implicated in athersclerosis. Unsaturated fats are inherently dangerous because of free radical production if antioxidant status is too low. IMO, it is slightly incorrect to say that any fats are 'toxic', although in conjunction with other things, they may have toxic effects. > 3) protein > essential nutrients, essential to maintainance of PH balance by > kidney > increases nitrogen load on kidneys Only increase nitrogen load significantly if eaten in excess or in highly unbalance form (ie. not the amino acid proportions required for the body's non-fuel amino acid needs) > 4) non-fibre carbs > no nutritional value other than calories, > though some high carb > foods are good sources of vitamin C And mainly other important vitamins/nutrients. > liver has limited capacity to process fructose, associated with > high fasting TG levels So eat vegetables which contains little fructose (and in general much longer metabolizing carbohydrates) instead of so much fruit! > and high uric acid levels (gout and some kidney stones) You are mixed up here. Uric acid contains nitrogen and is formed from nucleic acid breakdown. Its formation is not related to carbohydrates. > glucose is associated with high fasting TG, But it is not causal for it. > hyperinsulinism (syndrome X, etc), interconversion to toxic > sorbitol, glycation of proteins, etc. But again it is not glucose per se, but the rate of release of it into the blood stream (glycemic index of the food involved) and the chronic effect on the pancreas which is more important wrt these harmful effects. IMO, the uses and purposes of these nutrients are so different that such a comparative 'scale' is more misleading than usefull. --Tom Tom Matthews The LIFE EXTENSION FOUNDATION - http://www.lef.org - 800-544-4440 A non-profit membership organization dedicated to the extension of the healthy human lifespan through ground breaking research, innovative ideas and practical methods. LIFE EXTENSION MAGAZINE - The ultimate source for new health and medical findings from around the world. From owner-cardiovascular@net.bio.net Mon Jul 12 07:36:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!newsfeed.berkeley.edu!su-news-hub1.bbnplanet.com!sanjose-news-feed1.bbnplanet.com!news.gtei.net!nntp.mainstreet.net!news.mainstreet.net!feeder.swcp.com!sloth.swcp.com!llama.swcp.com!not-for-mail From: lewitt@swcp.com (Martin E. Lewitt) Newsgroups: bionet.biology.cardiovascular,sci.life-extension Subject: Re: arginine much better than lovastatin Date: 12 Jul 1999 01:46:33 -0600 Organization: Lewitt family, Sandia Park, NM Lines: 63 Message-ID: <7mc6gp$2ng@llama.swcp.com> References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> <7m3u2g$731$2@sylvester.vcn.bc.ca> <7m9d9f$jnl@llama.swcp.com> <37890AB1.2F67@netcom.ca> NNTP-Posting-Host: llama.swcp.com In article <37890AB1.2F67@netcom.ca>, Tom Matthews wrote: >Martin E. Lewitt wrote: >> liver has limited capacity to process fructose, associated with >> high fasting TG levels > >So eat vegetables which contains little fructose (and in general much >longer metabolizing carbohydrates) instead of so much fruit! > >> and high uric acid levels (gout and some kidney stones) > >You are mixed up here. Uric acid contains nitrogen and is formed from >nucleic acid breakdown. Its formation is not related to carbohydrates. No, the association was noted first and then later research supplied the mechanism. The fructose binds free phosphate in the liver, leading to breakdown of adenosine (of ATP fame) and guanosine (sp? of GTP fame). In the extreme case, an energy crisis in and damage to the liver can result. Liver damage was one of the reasons fructose failed as a when tried as a replacement for glucose in IVs. A good reference with bibliographies on this issue is Textbook of Biochemistry with Clinical Correlations" edited by Thomas M. Devlin >> glucose is associated with high fasting TG, > >But it is not causal for it. Maybe not "causal", a high calorie diet with significant percentage of calories from non-fibre carbs is probably required. A high calorie diet without the carbs will not suffice because fasting TG is produced by the liver from fasting glucose levels. A low carber is producing glucose via gluconeogenesis from glycerol and glucogenic amino acids. The body is very good a avoiding the futile cycle of then converting that "expensive" glucose back to TG. However, I cannot rule out genetic defects (perhaps common) in this mechanism or perhaps diets high enough in protein that some is converted to TG. >> hyperinsulinism (syndrome X, etc), interconversion to toxic >> sorbitol, glycation of proteins, etc. > >But again it is not glucose per se, but the rate of release of it into >the blood stream (glycemic index of the food involved) and the chronic >effect on the pancreas which is more important wrt these harmful >effects. I believe high Calorie diets are probably also a prerequisite, which probably explains why high carb 3rd world diets do not see the problems we do. >IMO, the uses and purposes of these nutrients are so different that such >a comparative 'scale' is more misleading than usefull. I believe most people would benefit from eliminating fruits and starchy grains and veggies and substituting non-starchy veggies and nuts, assuming they can afford to take in sufficient Calories without cheap carbs and that they can supplement vitamin C which may be difficult to obtain without fruits. Personally, I have retained tomatoes as my only fruit. It was also my only fruit before I went on a low carb diet. -- Martin -- Personal, not work info: Martin E. Lewitt My opinions are Domain: lewitt@swcp.com P.O. Box 729 my own, not my Hm phone: (505) 281-3248 Sandia Park, NM 87047-0729 employer's. From owner-cardiovascular@net.bio.net Mon Jul 12 08:01:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!logbridge.uoregon.edu!feeder.nmix.net!198.59.136.4.MISMATCH!feeder.swcp.com!sloth.swcp.com!llama.swcp.com!not-for-mail From: lewitt@swcp.com (Martin E. Lewitt) Newsgroups: bionet.biology.cardiovascular,sci.life-extension Subject: Re: arginine much better than lovastatin Date: 12 Jul 1999 02:26:47 -0600 Organization: Lewitt family, Sandia Park, NM Lines: 85 Message-ID: <7mc8s7$327@llama.swcp.com> References: <7m1jc1$ipu$2@sylvester.vcn.bc.ca> <7m3u2g$731$2@sylvester.vcn.bc.ca> <7m9d9f$jnl@llama.swcp.com> NNTP-Posting-Host: llama.swcp.com In article , David Lloyd-Jones wrote: :Martin E. Lewitt wrote :> :> I suspect that meat is associated with increased mortality rates for :> one (or both) of two reasons, meat is also associated with high calorie :> diets and red meat is associated with high iron diets. : :That's a plausible and attractive theory. But if it's true it still leaves :the problem of how to eat red meat without getting the iron and the :calories. I try to counteract with antioxidents, and reduce absorption by combining red meats with high fibre foods. I checked my archives and see that I have have not saved any references on how to reduce iron absorption. Someplace I thought I read that tea can reduce iron absorption, but I can not confirm this. I drink LOTS of ice tea, probably at least 4 litres a day, and this at least supplies antioxidents even if I am wrong about the iron. :Any evidence on the proposition? How would you separate the iron :and calorie effects from the satfat ones? Has anybody done this? This is very difficult to do in populations studies. I guess I probably wouldn't believe any studies that did not identify specific mechanisms by which saturated, non-trans, fatty acids can be detrimental. If a mechanism exists, I doubt it would be a direct detriment, but probably an indirect detriment perhaps through competitively displacing a good unsaturated fatty acid. Tom has mentioned that the palmitic acid is the saturated fatty acid with evidence against it, I wonder if there is evidence of the mechanism. :> You've got 4 organic categories of macro-nutrients, what order would you :put :> them in on the toxicity scale, from lowest to highest? Here is :> my order: :> :> 1) fibre :> basically inert :> 2) fat :> saturated fat is relatively inert pure calories :> some unsaturated fats are beneficial and essential nutrients :> transfatty acids and some unsaturated fatty acids have some toxicty :> 3) protein :> essential nutrients, essential to maintainance of PH balance by :> kidney :> increases nitrogen load on kidneys :> 4) non-fibre carbs :> no nutritional value other than calories, though some high carb :> foods are good sources of vitamin C :> liver has limited capacity to process fructose, associated with :> high fasting TG levels and high uric acid levels (gout and :> some kidney stones) :> glucose is associated with high fasting TG, :> hyperinsulinism (syndrome X, etc), interconversion to toxic :> sorbitol, glycation of proteins, etc. : :I think this last is plausible only in a thoroughly reductive sense. If :those components were what we ate, then that might be the way we'd list them :in order. Both protein and "non-fibre carbs", however, are utterly :artificial categories once you step inside a kitchen. Meat, eggs, beans, :pulses and tofu are all different from each other in the ways they fit into :our diets, and fruits and vegetables act out their important roles not only :through their burnables but through their tens of thousands of builders and :constructors. I find it useful, because I take the approach of only avoiding the non-fibre carbs. If I avoid fruit, grain products, potatoes, rice and corn I'm pretty much there. I do have to moderate or be selective in my consumption of carrots, legumes and nuts. Sugar is out of course. There are probably other starchy foods to be avoided, but my taste in veggies in pretty narrow, though broad compared to my taste in fruits (tomotoes is the exhaustive list). I do nothing to potential concerns about protein. Reguarding fats, I avoid the chief sources of trans-fatty acids (margarine and other hydrogenated vegatable oils), and supplement with fish oil capsules and nuts, usually raw almonds, and make sure I eat chicken WITH the skin which is a good source of unsaturated fatty acids. -- Martin -- Personal, not work info: Martin E. Lewitt My opinions are Domain: lewitt@swcp.com P.O. Box 729 my own, not my Hm phone: (505) 281-3248 Sandia Park, NM 87047-0729 employer's. From owner-cardiovascular@net.bio.net Mon Jul 12 18:02:00 1999 Path: biosci!AOL.COM!NTGVISCO From: NTGVISCO@AOL.COM Newsgroups: bionet.biology.cardiovascular Subject: Looking for help from participants of this site. Date: 12 Jul 1999 12:02:07 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 1270 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net --part1_e607923f.24bb9336_boundary Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: 7bit I read your organizations objectives and believe that what I am doing falls within your charter. If not, please accept my apology in advance. I am presently the only employee of a start up medical device company focused on demonstrating that blood viscosity is an acknowledged, but, heretofore, overlooked, and underutilized risk factor in many diseases, especially cardiovascular. We believe a that a causal relationship can be demonstrated by providing a device that can accurately measure blood viscosity in realtime in it's own biological environment. We believe this demonstration and the device we are developing is a valuable additional tool and has the potential to redefine the way many diseases are initially identified and treated. Our company was founded by a Physician/entrepeneur who is interested in this subject and I have a small group of very talented mechanical engineers consulting for me. We have developed a patented new device called a Scanning Cn the technologyapillary Tube Viscometer. (SCTV) I have attached an article which explains the technology. It appeared in Review of Scientific Instruments (May). We are currently developing an integral disposable capillary component which will enable the direct connection to the patients venous system and permit the realtime measurement of Circulating whole blood viscosity (CWBV) If anyone at this site has an interest in the role of blood viscosity in atherogenesis and / or is interested in learning more about the technology, please e-mail me at NTGVISCO@aol.com. Respectfully, Neil Grossman --part1_e607923f.24bb9336_boundary Content-Type: application/zip; name="CHO-KI36.ZIP" Content-Transfer-Encoding: base64 Content-Disposition: attachment; filename="CHO-KI36.ZIP" UEsDBBQAAgAIAN1t0ibQs+edcawAAAA8AQAPAAAAQ2hvLWZpZ3VyZXMuZG9j7Lp5ONTv2zc+ drK1kp0iWxRlX0vRIkthkkFCZB3LGPtaFCFLyU6UQkOEsdMkW0j23ZAl+74vv2sW9bm/3/t3 3PfzPP88z3Hcwzkz7/M6r9e5n+/r7fCj5chw6idWLORfXooQMsjePg2E8h880n8KHIZAdMEH CaC9/f19CPG7KqD9/3n9P/O6DbEHP84QbshViB34dIS4gQxyfIBAyEghJIUkBRBWfD75qIa/ QKbJwdp5CA0klzad6odTPlhjglCQHGCRgVVKGkKVVBGqBFcOkM+0NJDhm9xUEH0IxZxiBYkh jnkM98ZaJQbRgZhAHkBsIObguoQk/48+LcxffWi8vk9gjZlq4bTAKa18ZqorfAKn9vcZIKQk uBqlINadMvikgZTRUnHfvE/Ffe79YaD3BXntPo6qyAgy4kBmiQtXsCSVUOC9I8QMcgV8mkIQ EFtgBy4OEMgPp5z/RB+IC94xPirIV8g0HZAgJSH5R82/uMFNVbvvS75fS+6LCwOOx/0BxAaE BUMCIWGF5IBIQyBbteBtGkJOAbmD12oLooCL/XWg/SHeJhzHGfIIfLfD64Pj9UEgysC/77Tc VPeBJvQ5AaAfF3Fyog0Qqr1MCIQa5I+UDKirZYV8xPNTvvJRAZnp80AOpz8bGJ0FEqADvu8S 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