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From: A.Shameli@btinternet.com (Ashley Shameli)
X-Newsgroups: uk.people.health,sci.med.cardiology,own.health.misc,misc.health,bionet.biology.cardiovascular,alt.support-heart,alt.support.heart-defects
Subject: Re: Alternatives to WARFARIN - re: aortic valve surgery
Date: Mon, 31 Jul 2000 21:41:37 GMT
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On Mon, 31 Jul 2000 13:57:01 +0100, Andy Anderson
<andy@aicuk.demon.co.uk> wrote:

>In article <39851117.45956251@news.btinternet.com>, Ashley Shameli
><A.Shameli@btinternet.com> writes
>>Hello,
>>
>>Could anyone point me in the way of information / web links about
>>possible alternatives to Warfarin, (probably still being developed)
>>which are safter to take? (if such a thing does exist)
>>
>>Thanks,
>>Ashley.
>Hi Ashley,
>I`m so pleased you mum has at LAST had her surgery but what a long wait
>for you all! Good luck.
>Go to: www.google.co.uk and do a search. I`ve just done it by using the
>words " alternative warfarin heart patients" A lot of info. came up
>which may help. Google seems like a great place for info. searching.
>pat@aicuk.demon.co.uk
>I`m still checking my husband`s heart NG!
>Pat
>-- 
>Andy Anderson


Pat,

Thanks for the information.
My mother DID finally get surgery, after her heart had swollen so
seriously that her blood pressure still won't go back up to normal
from being very low. She only waited 15 months, which is better than
the six yeras an elderly woman had waited.

NTL, it is all over.

Thanks a lot.

Ashley




From owner-cardiors@hgmp.mrc.ac.uk  Wed Aug  2 06:12:45 2000
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Subject: Re: Alternatives to WARFARIN - re: aortic valve surgery
Date: Wed, 2 Aug 2000 01:07:49 -0400
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I was on Warfarin and almost died from it. So was,and did my mother.
 My Father did die due to using. He had several strokes.
Now I and my Mother both are on Plavix,75mg.and an aspirin a day I am on a
325 mg daily cut in half taken half first thing in the morning, and second
half at supper time. Mother takes 3 baby aspirins 1 first thing in morning
and then one at 6 hours later and last 6 hours later or before bed time with
a glass of orange juice. both of us are doing better now, no worries about
bleeding to death.
We don't have to have blood work all the time now, only every 2 months.
Hope this gives you some needed info you needed.
MrDaytonO   (*-*)
"Ashley Shameli" <A.Shameli@btinternet.com> wrote in message
news:39851117.45956251@news.btinternet.com...
> Hello,
>
> Could anyone point me in the way of information / web links about
> possible alternatives to Warfarin, (probably still being developed)
> which are safter to take? (if such a thing does exist)
>
> Thanks,
> Ashley.





From owner-cardiors@hgmp.mrc.ac.uk  Fri Aug  4 21:46:38 2000
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Subject: Re: Alternatives to WARFARIN - re: aortic valve surgery
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Thanks for the reply.

I don't suppose you could elaborate, if it's not too personal?

I am interested, with my mother just post op, to see all the risks
etc. Can I ask if the doctors recommended you stop using Warfarin -
they told us the blood tests ensure it is safe.

Thanks,
Ashley

p/s could anyone who replies please CC to my email,
a.shameli@btinternet.com

My provider has messed up the news feed.

On Wed, 2 Aug 2000 01:07:49 -0400, "MrDaytonO"
<pds120da@*nospam*siscom.net> wrote:

>I was on Warfarin and almost died from it. So was,and did my mother.
> My Father did die due to using. He had several strokes.
>Now I and my Mother both are on Plavix,75mg.and an aspirin a day I am on a
>325 mg daily cut in half taken half first thing in the morning, and second
>half at supper time. Mother takes 3 baby aspirins 1 first thing in morning
>and then one at 6 hours later and last 6 hours later or before bed time with
>a glass of orange juice. both of us are doing better now, no worries about
>bleeding to death.
>We don't have to have blood work all the time now, only every 2 months.
>Hope this gives you some needed info you needed.
>MrDaytonO   (*-*)
>"Ashley Shameli" <A.Shameli@btinternet.com> wrote in message
>news:39851117.45956251@news.btinternet.com...
>> Hello,
>>
>> Could anyone point me in the way of information / web links about
>> possible alternatives to Warfarin, (probably still being developed)
>> which are safter to take? (if such a thing does exist)
>>
>> Thanks,
>> Ashley.
>
>




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Subject: Re: Alternatives to WARFARIN - re: aortic valve surgery
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I've been taking Warfarin Sodium (Coumadin) for three or four years now. =
 I was born in 1950, with a malformed aortic valve, and am awaiting =
valve replacement surgery, as the condition of my heart continues to =
deteriorate.  That's why I've been taking Coumadin, to prevent blood =
clots from forming when my atrium fibrillates.

It is a hassle to have to go in for regular blood tests, especially =
since my veins roll and collapse (referred to as "shy").  Generally they =
are difficult to tap into, unless the phlebotomist is really expert (I =
call them "vampires").  So, sometimes, it turns into a real ordeal.  I =
also have to maintain a uniform intake of dark leafy green vegetables.

On the other hand, before my doctors arrived at the best Coumadin level, =
a blood clot traveled down into my leg.  That was one of the worst =
experiences of my life (and I've had three brain surgeries).  When I =
thought about how much damage a clot could do to my brain, I decided the =
inconvenience of dealing with Coumadin was a small price to pay.

"Ashley Shameli" <A.Shameli@btinternet.com> wrote in message =
news:398c9722.9678136@news.btinternet.com...
| Thanks for the reply.
|=20
| I don't suppose you could elaborate, if it's not too personal?
|=20
| I am interested, with my mother just post op, to see all the risks
| etc. Can I ask if the doctors recommended you stop using Warfarin -
| they told us the blood tests ensure it is safe.
|=20
| Thanks,
| Ashley
|=20
| p/s could anyone who replies please CC to my email,
| a.shameli@btinternet.com
|=20
| My provider has messed up the news feed.
|=20
| On Wed, 2 Aug 2000 01:07:49 -0400, "MrDaytonO"
| <pds120da@*nospam*siscom.net> wrote:
|=20
| >I was on Warfarin and almost died from it. So was,and did my mother.
| > My Father did die due to using. He had several strokes.
| >Now I and my Mother both are on Plavix,75mg.and an aspirin a day I am =
on a
| >325 mg daily cut in half taken half first thing in the morning, and =
second
| >half at supper time. Mother takes 3 baby aspirins 1 first thing in =
morning
| >and then one at 6 hours later and last 6 hours later or before bed =
time with
| >a glass of orange juice. both of us are doing better now, no worries =
about
| >bleeding to death.
| >We don't have to have blood work all the time now, only every 2 =
months.
| >Hope this gives you some needed info you needed.
| >MrDaytonO   (*-*)
| >"Ashley Shameli" <A.Shameli@btinternet.com> wrote in message
| >news:39851117.45956251@news.btinternet.com...
| >> Hello,
| >>
| >> Could anyone point me in the way of information / web links about
| >> possible alternatives to Warfarin, (probably still being developed)
| >> which are safter to take? (if such a thing does exist)
| >>
| >> Thanks,
| >> Ashley.
| >
| >
|=20

------=_NextPart_000_011D_01BFFE2C.25A5C420
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<BODY bgColor=3D#ffffff>
<DIV align=3Djustify><FONT size=3D4>I've been taking Warfarin Sodium =
(Coumadin) for=20
three or four years now.&nbsp; I was born in 1950, with a malformed =
aortic=20
valve, and am awaiting valve replacement surgery, as the condition of my =
heart=20
continues to deteriorate.&nbsp; That's why I've been taking Coumadin, to =
prevent=20
blood clots from forming when my atrium fibrillates.</FONT></DIV>
<DIV><FONT size=3D4></FONT>&nbsp;</DIV>
<DIV align=3Djustify><FONT size=3D4>It <U>is</U> a hassle to have to go =
in for=20
regular blood tests, especially since my veins roll and collapse =
(referred to as=20
"shy").&nbsp;&nbsp;Generally they are difficult to tap into, unless the=20
phlebotomist is really expert (I call them "vampires").&nbsp;&nbsp;So,=20
sometimes, it turns into a real ordeal.&nbsp; I also have to maintain a =
uniform=20
intake of dark leafy green vegetables.</FONT></DIV>
<DIV align=3Djustify><FONT size=3D4></FONT>&nbsp;</DIV>
<DIV align=3Djustify><FONT size=3D4>On the other hand, before my doctors =
arrived at=20
the best Coumadin level, a blood clot traveled down into my leg.&nbsp; =
That was=20
one of the worst experiences of my life (and I've had three brain=20
surgeries).&nbsp; When I thought about how much damage a clot could do =
to my=20
brain, I decided the inconvenience of dealing with Coumadin was a small =
price to=20
pay.</FONT></DIV>
<DIV><FONT size=3D4></FONT>&nbsp;</DIV>
<DIV><FONT size=3D4>"Ashley Shameli" &lt;</FONT><A=20
href=3D"mailto:A.Shameli@btinternet.com"><FONT=20
size=3D4>A.Shameli@btinternet.com</FONT></A><FONT size=3D4>&gt; wrote in =
message=20
</FONT><A href=3D"news:398c9722.9678136@news.btinternet.com"><FONT=20
size=3D4>news:398c9722.9678136@news.btinternet.com</FONT></A><FONT=20
size=3D4>...</FONT></DIV><FONT size=3D4>| Thanks for the reply.<BR>| =
<BR>| I don't=20
suppose you could elaborate, if it's not too personal?<BR>| <BR>| I am=20
interested, with my mother just post op, to see all the risks<BR>| etc. =
Can I=20
ask if the doctors recommended you stop using Warfarin -<BR>| they told =
us the=20
blood tests ensure it is safe.<BR>| <BR>| Thanks,<BR>| Ashley<BR>| <BR>| =
p/s=20
could anyone who replies please CC to my email,<BR>| </FONT><A=20
href=3D"mailto:a.shameli@btinternet.com"><FONT=20
size=3D4>a.shameli@btinternet.com</FONT></A><BR><FONT size=3D4>| <BR>| =
My provider=20
has messed up the news feed.<BR>| <BR>| On Wed, 2 Aug 2000 01:07:49 =
-0400,=20
"MrDaytonO"<BR>| &lt;</FONT><A =
href=3D"mailto:pds120da@*nospam*siscom.net"><FONT=20
size=3D4>pds120da@*nospam*siscom.net</FONT></A><FONT size=3D4>&gt; =
wrote:<BR>| <BR>|=20
&gt;I was on Warfarin and almost died from it. So was,and did my =
mother.<BR>|=20
&gt; My Father did die due to using. He had several strokes.<BR>| =
&gt;Now I and=20
my Mother both are on Plavix,75mg.and an aspirin a day I am on a<BR>| =
&gt;325 mg=20
daily cut in half taken half first thing in the morning, and second<BR>| =

&gt;half at supper time. Mother takes 3 baby aspirins 1 first thing in=20
morning<BR>| &gt;and then one at 6 hours later and last 6 hours later or =
before=20
bed time with<BR>| &gt;a glass of orange juice. both of us are doing =
better now,=20
no worries about<BR>| &gt;bleeding to death.<BR>| &gt;We don't have to =
have=20
blood work all the time now, only every 2 months.<BR>| &gt;Hope this =
gives you=20
some needed info you needed.<BR>| &gt;MrDaytonO&nbsp;&nbsp; (*-*)<BR>|=20
&gt;"Ashley Shameli" &lt;</FONT><A =
href=3D"mailto:A.Shameli@btinternet.com"><FONT=20
size=3D4>A.Shameli@btinternet.com</FONT></A><FONT size=3D4>&gt; wrote in =

message<BR>| &gt;news:39851117.45956251@news.btinternet.com...<BR>| =
&gt;&gt;=20
Hello,<BR>| &gt;&gt;<BR>| &gt;&gt; Could anyone point me in the way of=20
information / web links about<BR>| &gt;&gt; possible alternatives to =
Warfarin,=20
(probably still being developed)<BR>| &gt;&gt; which are safter to take? =
(if=20
such a thing does exist)<BR>| &gt;&gt;<BR>| &gt;&gt; Thanks,<BR>| =
&gt;&gt;=20
Ashley.<BR>| &gt;<BR>| &gt;<BR>| </FONT></BODY></HTML>

------=_NextPart_000_011D_01BFFE2C.25A5C420--




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From owner-cardiors@hgmp.mrc.ac.uk  Tue Aug  8 23:06:59 2000
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From: A.Shameli@btinternet.com (Ashley Shameli)
X-Newsgroups: uk.people.health,sci.med.cardiology,own.health.misc,misc.health,bionet.biology.cardiovascular,alt.support-heart,alt.support.heart-defe
Subject: URGENT - help needed for post-op AORTIC VALVE REPLACEMENT - URGENT
Date: Tue, 08 Aug 2000 21:19:48 GMT
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Hello,

As some helpful members already know, after a long wait (well over a
year when she learnt she needed an operation urgently) my mother
underwent valve surgery to replace her aortic valve.

A little information first which might help:-
- the operation took place on Monday 24th July (ie as of today,
08.08.00, two weeks and a day have passed) - and she was let out of
hospital on Sunday 6th August
- she left the valve replacement to the surgeon, who opted for
a carbon-fibre valve because the hole was too small for a pig
valve apparently
- my mother has SVT, a condition possibly linked to the valve problem
according to the surgeon, which resulted in irregular heartbeats a few
years ago
- the operation took place in the Queen Elizabeth Hospital,
Birmingham, England, and was carried out by Mr Keogh and his assistant
Mr Satur (if this is relevant)
- the doctors/surgeon said when they opened my mother up the heart had
swelled very badly, and I am not sure if it has reduced in size yet,
so this MIGHT have an afffect on her current condition (see below)

Now, the problem is, in the hospital she felt very weak, and the
doctors said she had a low blood count. They attributed this to a form
of amenia (a result of the operation and NOT a pre-operation
condition) and considered a blood transfusion to return the cell count
to normal, but opted to go against it and gave her drugs to increase
her red-cell count.

I understand the weakness post-op is usual, BUT she is still very weak
(which she thinks is due to the anemia as she gets breathless after
walking even after the operation) and to compliate the situation she
is still very tired and she has a temperature. At the Queen Elizabeth
Hospital they gave her antibitoics into the vain on a drip for a few
days to clear up any infections incase they were in the valve.

In hospital this stabalised for 24 hours so she was let out, BUT she
has been taking her own temperature at home and it has fluctuated upto
37.8 degrees C, 0.2 degrees below when she has to call the hospital
according to the doctors.


Now, can anyone shed any information, possibly from past experiences,
which can help put her mind at rest. We are all concerned the
temperature hasn't subsided - and she is now off the antibitics so a
virus at the moment could be very nasty.


Thanks for taking the time,
Ashley.




From owner-cardiors@hgmp.mrc.ac.uk  Wed Aug  9 01:12:40 2000
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From: "Carol T" <Ateasd5941@btinternet.com>
X-Newsgroups: uk.people.health,sci.med.cardiology,own.health.misc,misc.health,bionet.biology.cardiovascular,alt.support-heart,alt.support.heart-defe
Subject: Re: URGENT - help needed for post-op AORTIC VALVE REPLACEMENT - URGENT
Date: Wed, 9 Aug 2000 00:01:25 +0100
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Ashley Shameli <A.Shameli@btinternet.com> wrote in message
news:39917303.13367261@news.btinternet.com...

>>>>> Now, can anyone shed any information, possibly from past experiences,
> which can help put her mind at rest. We are all concerned the
> temperature hasn't subsided - and she is now off the antibitics so a
> virus at the moment could be very nasty.<<<<<<

Antibiotics won't get rid of a virus anyway.

I read once that if someone takes cold/cool baths it raises the blood count
and would help with the temperature. You should speak to her Dr really to
find out what's going on, there are medical conditions that raise body temp
and also cause palpitations and heart problems. Do you know what her temp
was before the operation?

I should think that heart surgery is very stressful to get over, not like
having a tooth out. Are you sure that everyone isn't fussing her?

Carol T





From owner-cardiors@hgmp.mrc.ac.uk  Wed Aug  9 21:46:10 2000
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From: "Taylor Robbins" <trobbins@interlog.com>
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Subject: Great New Cloning Software
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I have been using a program called Redasoft Plasmid for the past year to aid
me in my research. Redasoft recently released a beta version of their new
program, Visual Cloning 2000. I thought I would recommend it to you all
because I am really impressed by the great graphics and new features.
Redasoft has added ORF searching, primer design, a sequence viewer, and more
web integration. I've tried Vector NTI and a few others, but found them
mostly too expensive and confusing. You can download the beta version of
Visual Cloning 2000 at http://www.redasoft.com.

Dr. Taylor Robbins





From owner-cardiors@hgmp.mrc.ac.uk  Sun Aug 13 22:52:10 2000
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Date: 13 Aug 2000 21:51:06 GMT
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Subject: aortic valve
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This I am told creates an enlarged heart.  Is it advisable to have surgery? 
I'm 73 Thanks, Mary




From owner-cardiors@hgmp.mrc.ac.uk  Sat Aug 19 19:10:08 2000
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From: "John F. Black" <jaybee@iweb.net.au>
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Subject: Bio /anatomy Questions
Date: Sat, 19 Aug 2000 17:40:24 +0930
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Hi, can somebody help with the following queries?
What is the largest cell in the body?
Which lung is the smaller?
What is the name of the two lines that run from your top lip to your nose?
Women or men's hearts beat faster?
What is the body's largest internal organ?

Hope some one can help gran-daughter for school assignment.
jaybee@iweb.net.au





From owner-cardiors@hgmp.mrc.ac.uk  Sun Aug 20 01:47:17 2000
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From: "kanda" <kanda@biomedika.com>
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Subject: Want to Buy: Pre-owned Laboratory Equipment
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We urgently need the following pre-owned lab items:

1. Millipore Pellicon 2/Pellicon cassette system
2. Pharmacia FPLC with full configuration
3. HPLC 1100, HP model, without autosampler
4. UV/Vis spectrophotometer; recent model; kinetics and scanning
capabilities
5. Power supplies; Pharmacia, Hoefer, or BioRad model; 500V and 2000V
6. High speed centrifuge: benchtop; very recent Beckman model
7. Thermostatic circulator; Pharmacia MultiTemp III model
8. Inverted Microscope with camera; biological application; Nikon, Olympus,
or Zeiss recent model
9. electrophoresis gel image analysis system with fluorescence and UV
application
10. Microplate reader: very recent Bio-Tek, Molecular device or Labsystems
model
11. Microplate fluorescence reader: recent model
12. PCR system; Perkin Elmer 9600 or 9700
13. pH meter
14. Balance; top loading; 0.001g unit
15. Water purifucation system; Milli Q and Milli RO or Barnstead Easy Pure
RO and NanoPure ; recent tabletop
16. Vacuum gel dryer system; Hoefer model
17. Complete Speed-Vac system for protein purifucation; Savant model
18. microcentrifuge, refrigerated; recent Eppendorf model
19. microcentrifuge; recent Eppendorf model
20. tabletop centrifuge with adaptor for 50ml conical tube, refrigerated;
recent model
21. Deep Freezer: Revco or Forma model;  about 300L or 500 L; -86C
22. Shaker, oscilator type; Hoefer
23. Shaker, orbital type; Hoefer
24. Vortex mixer (Genie 2)
25. Stirrer (Labline, Thermolyne, Corning, etc.)
26. Hot plate stirrer (Labline, Thermolyne, Corning, etc.)
27. Transilluminator; UV/Vis; Hoefer
28. Photodocumentation system (PhotoMan direct gel documentation system);
Hoefer
29. Electrophoresis system; recent Novex model
30. BD FACSort Cell Sorter
31.  Perkin Elmer ABI 377 DNA Sequencer

If you have any of the above items or know anybody willing to sell please
contact me.  Please submit offers with full specs, pictures and pricing.
You can also submit your offers to sell  using our classified ads section at
http://www.biomedika.com   Registration and Postings are FREE!

Thanks.

Kanda
Tel. 1-514-684-0226
kanda@biomedika.com








From owner-cardiors@hgmp.mrc.ac.uk  Sun Aug 20 02:10:01 2000
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From: Doug Skrecky <oberon@vcn.bc.ca>
X-Newsgroups: bionet.biology.cardiovascular,sci.life-extension
Subject: pravastatin is safer than other statins
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Title
  Lipophilic HMG-CoA
  reductase inhibitors increase myocardial stunning in dogs.
Source
  Journal of Cardiovascular Pharmacology.  35(2):256-62, 2000 Feb.
Abstract
  Pretreatment of dogs with simvastatin, a lipophilic
  3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
  reductase inhibitor, increases myocardial contractile
  dysfunction during reperfusion after ischemia (stunning), with reduction of
  tissue adenosine triphosphate (ATP). This was thought to be a consequence of
  prevention of ubiquinone biosynthesis by the lipophilic
  inhibitor in the myocardial cell. We examined whether other
  lipophilic HMG-CoA
  reductase inhibitors also influence myocardial stunning in
  dogs. Vehicle, atorvastatin (2 mg/ kg/day), fluvastatin (4 mg/kg/day), or
  cerivastatin (40 microg/kg/ day) was orally administered for 3 weeks.
  Hydrophilic pravastatin (4 mg/kg/day) also was given. After 3 weeks,
  pentobarbital-anesthetized dogs were subjected to 15-min left anterior
  descending coronary artery occlusion followed by 2-h reperfusion. Myocardial
  segment function was determined by sonomicrometry. Tissue levels of ATP were
  determined in 2-h reperfused hearts. All inhibitors significantly decreased
  serum cholesterol level. The three lipophilic inhibitors
  resulted in a worsening of segment function in the reperfused myocardium, as
  compared with the vehicle group. The levels of ATP in the atorvastatin,
  fluvastatin, and cerivastatin groups were significantly lower than that in
  the vehicle group. These results confirm that lipophilic
  HMG-CoA reductase inhibitors enhance
  myocardial stunning in association with ATP reduction after ischemia and
  reperfusion.




From owner-cardiors@hgmp.mrc.ac.uk  Sun Aug 20 02:11:00 2000
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From: Doug Skrecky <oberon@vcn.bc.ca>
X-Newsgroups: bionet.biology.cardiovascular,sci.life-extension
Subject: ramipril may be the best ACE inhibitor
Date: 20 Aug 2000 01:04:23 GMT
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Title
  Ramipril vs captopril in mild to moderate
  hypertension.
Source
  Journal of the Association of Physicians of India.  42(2):120-3, 1994 Feb.
Abstract
  Ramipril 5 mg once daily was compared to
  Captopril 50 mg twice daily in a randomised, double-blind,
  parallel group study in 60 patients with a diastolic blood pressure between
  95 to 120 mmHg over a period of 2 months. Both drugs in the dose regimen used
  in this study exerted a similar anti-hypertensive effect at the end of 2
  months of treatment resulting in a fall of supine diastolic blood pressure
  with Ramipril = 19.27 +/- 3.34 mmHg and
  Captopril = 19.15 +/- 2.63, in patients receiving the drugs
  without the diuretic. The mean fall in supine diastolic blood pressure 4
  hours after the first dose of Ramipril was 6.5 mmHg and
  Captopril 8 mmHg. None of the patients developed first dose
  hypotension or orthostatic hypotension and there was no significant
  alteration of the heart rate in either group. The serum K+ levels remained
  unchanged in both groups of patients. Both drugs were well tolerated and
  there were no adverse effects observed on the liver, kidney, blood sugar or
  haemopoietic system. Based on the results of this study, it can be concluded
  that the antihypertensive efficacy of 5 mg ramipril in a
  once daily dose is equivalent to 50 mg captopril given twice
  daily. However an appreciably greater number of patients reported improvement
  in the "quality of life' parameters with ramipril as
  compared to captopril. Thus for the routine treatment of
  mild to moderate arterial hypertension, ramipril offers
  reliable antihypertensive efficacy in a once daily dose, thereby helping to
  improve patient compliance and making the treatment more economical.




From owner-cardiors@hgmp.mrc.ac.uk  Mon Aug 21 21:15:34 2000
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From: A.Shameli@btinternet.com (Ashley Shameli)
X-Newsgroups: uk.people.health,sci.med.cardiology,own.health.misc,misc.health,bionet.biology.cardiovascular,alt.support-heart,alt.support.heart-defect
Subject: Post Aortic-Valve Replacement Walking
Date: Mon, 21 Aug 2000 20:13:52 GMT
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Dear members,

I have noticed a lot about people post bypass being meant to walk.

My mother, now three days off one month post-op from an aortic valve
replacement, has had no such advice and has done very little
excercise.

Should she start doing some?


Thanks,
Ashley

a.shameli@btinternet.com




From owner-cardiors@hgmp.mrc.ac.uk  Tue Aug 22 02:17:02 2000
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Subject: Re: Post Aortic-Valve Replacement Walking
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Yes, she should begin.  I (59 YO Male) began walking around the kitchen,
dining room, living room for a few days 1 week post op.  Then went out
to a parking lot (didn't like that).  Then around the block.  Then 1/4
mile on level streets 3rd week.  Then worked up to 2 miles, 3 miles and
then my standard 3.5 mile walk with hills, 12 week post-op.

It's good for your circulation and peace of mind.  (I was fortunate to
walk throughout spring-time in Maryland.  Beautiful.




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From owner-cardiors@hgmp.mrc.ac.uk  Tue Aug 22 11:30:12 2000
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From: juan <asesauta@yahoo.com>
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Subject: Re: ramipril may be the best ACE inhibitor
Date: Tue, 22 Aug 2000 12:20:42 +0200
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OK, I am beginning with the subject of cardiololgy. In your mail, Doug, you talk
about the bettect,er behaviour of ramipril vs captopril treating hypertension, but
in the subject you talk about the best ACE inhibitor. What has to do one thing with
the other? is there any relationship?  Thank you

juan

Doug Skrecky wrote:

> Title
>   Ramipril vs captopril in mild to moderate
>   hypertension.
> Source
>   Journal of the Association of Physicians of India.  42(2):120-3, 1994 Feb.
> Abstract
>   Ramipril 5 mg once daily was compared to
>   Captopril 50 mg twice daily in a randomised, double-blind,
>   parallel group study in 60 patients with a diastolic blood pressure between
>   95 to 120 mmHg over a period of 2 months. Both drugs in the dose regimen used
>   in this study exerted a similar anti-hypertensive effect at the end of 2
>   months of treatment resulting in a fall of supine diastolic blood pressure
>   with Ramipril = 19.27 +/- 3.34 mmHg and
>   Captopril = 19.15 +/- 2.63, in patients receiving the drugs
>   without the diuretic. The mean fall in supine diastolic blood pressure 4
>   hours after the first dose of Ramipril was 6.5 mmHg and
>   Captopril 8 mmHg. None of the patients developed first dose
>   hypotension or orthostatic hypotension and there was no significant
>   alteration of the heart rate in either group. The serum K+ levels remained
>   unchanged in both groups of patients. Both drugs were well tolerated and
>   there were no adverse effects observed on the liver, kidney, blood sugar or
>   haemopoietic system. Based on the results of this study, it can be concluded
>   that the antihypertensive efficacy of 5 mg ramipril in a
>   once daily dose is equivalent to 50 mg captopril given twice
>   daily. However an appreciably greater number of patients reported improvement
>   in the "quality of life' parameters with ramipril as
>   compared to captopril. Thus for the routine treatment of
>   mild to moderate arterial hypertension, ramipril offers
>   reliable antihypertensive efficacy in a once daily dose, thereby helping to
>   improve patient compliance and making the treatment more economical.




From owner-cardiors@hgmp.mrc.ac.uk  Wed Aug 23 02:36:59 2000
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From owner-cardiors@hgmp.mrc.ac.uk  Wed Aug 23 23:37:33 2000
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From: Doug Skrecky <oberon@vcn.bc.ca>
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Subject: policosanol may be the best lipid lowering supplement
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Citations: 1-5
<1>
Title
  [Comparative effects of policosanol and two HMG-CoA
  reductase inhibitors on type II hypercholesterolemia]. [Spanish]
Source
  Revista Medica de Chile.  127(3):286-94, 1999 Mar.
Abstract
  BACKGROUND: Policosanol is a new cholesterol lowering agent
  derived from sugar cane. AIM: To compare the cholesterol lowering efficacy of
  policosanol with HMG CoA inhibitors. PATIENTS AND METHODS:
  Patients with a LDL cholesterol over 160 mg/dl were studied. If, after 6
  weeks of diet, cholesterol persisted elevated, they were doubly blind
  randomized to receive policosanol 10 mg/day (55 patients),
  lovastatin 20 mg/day (26 patients) or simvastatin 10 mg/day (25 patients).
  Serum cholesterol was measured again after 8 weeks of therapy. RESULTS:
  Initial demographic and laboratory data were similar among treatment groups.
  A 24% LDL cholesterol reduction was obtained with
  policosanol, compared with a 22% reduction with lovastatin
  and a 15% reduction with simvastatin. HDL cholesterol significantly increased
  in patients on policosanol and did not change in the other
  treatment groups. Adverse effects of policosanol were mild
  and unspecific. No changes in hepatic enzymes were observed. CONCLUSIONS:
  Policosanol is a safe and effective cholesterol reducing
  agent.

<2>
Title
  Effects of policosanol in patients with type II
  hypercholesterolemia and additional coronary risk factors.
Source
  Clinical Pharmacology & Therapeutics.  65(4):439-47, 1999 Apr.
Abstract
  INTRODUCTION: This study was undertaken to evaluate the efficacy, safety, and
  tolerability of policosanol, a new cholesterol-lowering
  drug, in patients with type II hypercholesterolemia and additional coronary
  risk factors. PATIENTS AND METHODS: After 5 weeks of a standard step-1
  lipid-lowering diet, 437 patients were randomized to receive, under
  double-blind conditions, 5 mg policosanol or placebo once a
  day with the evening meal for 12 weeks and 10 mg policosanol
  or placebo for the next 12 weeks. RESULTS: Both groups were similar at
  randomization. Policosanol (5 and 10 mg/day) significantly
  reduced (P < .001) serum low-density lipoprotein cholesterol (18.2% and
  25.6%, respectively) and cholesterol (13.0% and 17.4%), and it significantly
  raised (P < .01) high-density lipoprotein cholesterol (15.5% and 28.4%).
  Triglycerides remained unchanged after the first 12 weeks and lowered
  significantly (5.2%; P < .01) at study completion.
  Policosanol was safe and well tolerated, and no drug-related
  disturbances were observed. Two male patients who received placebo died
  during the study--one because of a myocardial infarction and the other
  because of a cardiac arrest that occurred during a surgical intervention.
  There were 11 serious adverse events (5.1%) in 10 patients who received
  placebo (4.6%), 7 of which were vascular, compared with no serious adverse
  events reported in patients receiving policosanol (P < .01).
  CONCLUSIONS: Subjects in the group treated with policosanol
  did not have serious adverse events during the 24-week study. This study
  shows that policosanol is effective, safe, and well
  tolerated in patients with hypercholesterolemia and concomitant coronary risk
  factors.

<3>
Title
  A double-blind, placebo-controlled study of the effects of
  policosanol in patients with intermittent claudication.
Source
  Angiology.  50(2):123-30, 1999 Feb.
Abstract
  This study was undertaken to evaluate the efficacy and tolerability of
  policosanol, a new cholesterol-lowering drug with
  concomitant antiplatelet effects, in patients with intermittent claudication.
  After a baseline period of 6 weeks, 62 patients were randomized to receive,
  under double-blind conditions, either placebo (31 patients) or
  policosanol (31), 10 mg twice daily. Walking distances in a
  treadmill (constant speed 3.2 km/hr, slope 10 degrees) were assessed before
  and after 6 months of treatment. Both groups were similar at randomization.
  Policosanol increased significantly (p < 0.01) the initial
  claudication distance from 132.5+/-13.5 m (baseline) to 205.7+/-36.3 m (after
  therapy) and the absolute claudication distance (p<0.0001) from 229.5+/-22.0
  m to 365.4+/-46.9 m; meanwhile both variables remained unchanged in the
  placebo group (p<0.05). The reduction of lower limb symptoms showed a greater
  benefit in the policosanol group. There was no significant
  change in either group in the ankle/arm pressure ratio. The treatment was
  well tolerated. There were 10 discontinuations (seven placebo, three
  policosanol) from the study. Six withdrawals occurred
  because of adverse events (AE); all were in placebo patients. There were five
  serious vascular AEs in the placebo group but none in the
  policosanol group (p<0.05). Overall, 12/31 (38.7%) placebo
  patients and 3/31 (9.7%) policosanol patients experienced
  AEs after randomization, which showed a lesser incidence of AEs in the
  policosanol group (p<0.01). The present study demonstrates a
  beneficial effect of policosanol in patients with
  intermittent claudication.

<4>
Title
  Effect of policosanol on intimal thickening in rabbit cuffed
  carotid artery.
Source
  International Journal of Cardiology.  67(2):125-32, 1998 Dec 1.
Abstract
  We studied the effect of policosanol on smooth muscle cell
  proliferation in the cuffed carotid artery of the rabbit.
  Policosanol is a mixture of higher aliphatic primary
  alcohols isolated from sugar cane wax, with cholesterol lowering effects
  proved in experimental models and patients with type II hypercholesterolemia.
  It acts by inhibiting cholesterol biosynthesis. The positioning of a
  nonocclusive silicone collar around the rabbit carotid artery results in the
  formation of a neointima. We wished to determine whether
  policosanol orally administered prevented intimal
  thickening. Collars were placed around the left carotid for 15 days. The
  contralateral artery was sham operated. We included three experimental
  groups: a control received vehicle and two others
  policosanol at 5 and 25 mg Kg until sacrificed. Samples of
  arteries were examined by light and electron microscopy. To evaluate intimal
  thickening the cross-sectional area of intima and media were measured.
  Neointima was significantly reduced in policosanol-treated
  animals compared with controls. The smooth muscle cell proliferation was
  studied by the immunohistochemical detection of proliferating cell nuclear
  antigen and a significant reduction was observed in
  policosanol treated rabbits. It is concluded that
  policosanol has a protective effect on the neointima
  formation in this experimental model.

<5>
Title
  Long-term therapy with policosanol improves treadmill
  exercise-ECG testing performance of coronary heart disease patients.
Source
  International Journal of Clinical Pharmacology & Therapeutics.  36(9):469-73,
  1998 Sep.
Abstract
  This study examined the effects of long-term lipid-lowering therapy with
  policosanol on the clinical evolution, and exercise-ECG
  testing responses of 45 coronary heart disease (CHD) patients with myocardial
  ischemia, documented by exercise 201T1-myocardial perfusion scintigraphy, in
  an overall randomized, double-blind, placebo-controlled trial, made for
  different test endpoints. Fifteen patients were treated with 5 mg of
  policosanol twice daily; another 15 patients were
  administered the same drug dose plus 125 mg aspirin; and the other 15
  patients received placebo plus equal aspirin dose. They were followed for 20
  months, previous baseline observations, with treadmill exercise-ECG, besides
  serum lipid test. Beneficial changes on proportions among the 2
  policosanol groups and the placebo group, showed an
  increment on functional capacity class, a decrement on rest and exercise
  angina, and a significant decrease in cardiac events, and in ischemic ST
  segment response, especially in the policosanol plus aspirin
  group (p = 0.05, X2(2df) = 5.8; p = 0.04, p = 0.02; Fisher). After treatment,
  sets of mean changes revealed an increase on maximum oxygen uptake, and a
  decline on double product simultaneously in both policosanol
  groups (p < or = 0.02, p < or = 0.002; Pillais, Hotellings' T2), while the
  placebo group was impaired. Aerobic functional capacity percent showed an
  increment in policosanol groups (p < or = 0.05, paired T).
  Lipid levels improved as other endpoints already reported. A supposed
  ergogenic effect of octacosanol, policosanol's main active
  compound, was not detected with this design. These results show that
  policosanol-treated CHD patients improved clinical
  evolution, and exercise-ECG responses, owing to the amelioration of
  myocardial ischemia, even more when administered with aspirin.






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Subject: Re: Post Aortic-Valve Replacement Walking
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Ashley Shameli wrote in message <39a28ce6.9952060@news.btinternet.com>...
>Dear members,
>
>I have noticed a lot about people post bypass being meant to walk.
>
>My mother, now three days off one month post-op from an aortic valve
>replacement, has had no such advice and has done very little
>excercise.

Walking certainly seems to be the number one recommendation.  My cardiac
exercise adviser recommended building up from (virtually) nothing to 1.5
miles in 45 minutes over a 6-week period.  That, or course, assumes that 1.5
miles in 45 minutes was 'normal' *before* the operation.
One problem, of course is horizontal versus vertical distance.  A mile
uphill is *much* more demanding that a mile on the flat.
Aspirations/personal targets seem to range from half a mile to seven miles
daily. YMMV even more!!  My adviser also mentioned that (especially if you
live in a hilly area) an exercise bike or similar was just as good, from the
body's point of view.

HTH

GT





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From: Tony Sayer <tony@bancom.demon.co.uk>
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Subject: Re: Post Aortic-Valve Replacement Walking
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References: <39a28ce6.9952060@news.btinternet.com>
 <QL7p5.3127$pi.15584@NewsReader>
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In article <QL7p5.3127$pi.15584@NewsReader>, Arbub
<gtaylor@btconnect.com> dictates
>
>Ashley Shameli wrote in message <39a28ce6.9952060@news.btinternet.com>...
>>Dear members,
>>
>>I have noticed a lot about people post bypass being meant to walk.
>>
>>My mother, now three days off one month post-op from an aortic valve
>>replacement, has had no such advice and has done very little
>>excercise.
>
>Walking certainly seems to be the number one recommendation.  My cardiac
>exercise adviser recommended building up from (virtually) nothing to 1.5
>miles in 45 minutes over a 6-week period.  That, or course, assumes that 1.5
>miles in 45 minutes was 'normal' *before* the operation.
>One problem, of course is horizontal versus vertical distance.  A mile
>uphill is *much* more demanding that a mile on the flat.
>Aspirations/personal targets seem to range from half a mile to seven miles
>daily. YMMV even more!!  My adviser also mentioned that (especially if you
>live in a hilly area) an exercise bike or similar was just as good, from the
>body's point of view.
>
>HTH
>
>GT
>
>

Looking at the American sites re heart trouble, hypertension etc.
 ALL of them seem to recommend excersise as  something of a  wonder
drug!.


-- 
Tony Sayer                              

Bancom Communications Ltd U.K.   Tel +44 1223 566577    Fax +44 1223 566588

P.O. Box 280, Cambridge, England, CB2 2DY    E-Mail tony@bancom.demon.co.uk

               TL447-553    52* 10.57'N  0* 6.96 E




From owner-cardiors@hgmp.mrc.ac.uk  Fri Aug 25 20:49:57 2000
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From: "kanda" <kanda@biomedika.com>
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Subject: New Online Equipment Classifieds at http://www.biomedika.com
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Buy, sell, trade or donate pre-owned medical, laboratory, clinical or
process equipment using our online classifieds. Use our Online Medical
Directory to locate physicians, dentists, pharmacists, medical clinics,
hospitals or other healthcare resources worldwide. Post offers, tenders or
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For more information visit ou web site at:  http://www.biomedika.com

Thanks.

Kanda
kanda@biomedika.com
Tel. 1-514-684-0226






From owner-cardiors@hgmp.mrc.ac.uk  Sat Aug 26 08:49:24 2000
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Reply-To: "Rune Falk" <rfalk@chello.no>
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Currently i am a 4th year medical student who is about to take on elective
project in Thoracic & Cardiovascular Surgery in one of the teaching hospital
in Norway. I would welcome any suggestion of project that would be
interesting and beneficial to take on. I have completed only 1 year of
clinical training which mainly involving history taking and investigation.
Any suggestion would be most appreciated.

med stu Norliza
leeza29@hotmail.com
rfalk@chello.no








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Subject: Investors Please Read - Strong Buy Recommendation on UVGI, please buy Today and double your money
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THE WALL STREET  WIZARD  NEWSLETTER
FOR  WEEK of  August 28 to September 1,  2000
 
Early Release (Friday at 5 p.m.)  to Members Only!
 
OUR STOCK PICK 
 
Early Release To BE Sent ONLY to:
Members, Group Leaders, Newsletter Owners and Financial Institution Managers Only!
 
NEWS & STRONG BUY ALERT:

UVGI  otc-bb
United Ventures Group
STRONG BUY RECOMMENDATION
 
UVGI Closed on Friday, August 25 at .135 for a GAIN of  8 % !
UVGI Closed on Thursday, August 24 at .125 for a GAIN of 15%  !
Target is $1.00 Short Term

UVGI has Doubled Their Revenue
UVGI has more than doubled their Profit
 
UVGI Reached a High of .95 on February 9, 2000 and closed that day at .80


UVGI REVENUES AND GROSS PROFITS HAVE DOUBLED & INCOME IS ALMOST ONE MILLION DOLLARS

EXTREMELY STRONG BUY 
FOR THESE  REASONS:

#1  - HUGE INCREASE IN REVENUE PROJECTIONS
#2  - BIG  DEMAND FROM ELECTRONIC SHOPPING NETWORKS
#3  - REDUCED PRODUCTION EXPENSES
#4  - SALES TO MOST OF THE WORLDS LARGEST DEPARTMENT STORES
#5  - FULLY REPORTING STATUS
#6  - ALLIANCE WITH DOPPLET & GREENWALD DIAMONDS
#7  - PROSPECTS OF ELEGANTCHOICE.COM WITH STRATEGIC ALLIANCES
#8  - AGGRESSIVE COMPANY ACQUISITION PLAN
#9  - FIFTY YEARS OF JEWELRY MANAGEMENT EXPERIENCE BETWEEN EXECUTIVES NUSSEN & WEISZ
-----------------
 
Wednesday August 23, 3:43 pm Eastern Time 
Press Release
United Ventures Group Poised to Launch Corporate Investor Web Site
New Web Site to be Launched On August 28, 2000
NEW YORK--(BUSINESS WIRE)--Aug. 22, 2000--United Ventures Group (OTCBB:UVGI - news), a premier designer, manufacturer and distributor of fine jewelry, today announced that it will launch its new Corporate Investor Web site on August 28, 2000. The Web site will be updated on a regular basis and can be accessed at the address www.UVGIINVESTOR.com 

The new Web site, intended for the investment community will feature current and archived filings with the Securities and Exchange Commission, press releases, real time quotes and corporate information. The Web site will be the premier information source for current investors and potential investors wishing to make informed investment decisions about United Ventures Group. 

For Full Newsrelease go to:  http://biz.yahoo.com/bw/000823/ny_united_.html

------------------------------------------------------------

Tuesday August 15, 7:00 am Eastern Time 
Press Release
United Ventures Group Reports Results for the Six Months Ended June 30, 2000
Company Reports Record Net Income
NEW YORK--(BUSINESS WIRE)--Aug. 15, 2000--United Ventures Group, Inc. (OTC BB:UVGI - news), a premier designer, manufacturer and distributor of fine jewelry, today reported results for the second quarter ended June 30, 2000. 
For the six months ended June 30, 2000 net sales were $5,874,404 versus $3,028,642 for the six months ended June 30, 1999. Gross profit increased from $782,494 to $1,623,622 for the first six months of 2000. Income from operations increased to $951,043 from a loss of $2,108,477. 

Net income rose to $370,749 for the six months ended June 30th compared to a loss of $3,888,619 for the comparable period in 1999. 

Isaac Nussen, President and CEO, stated, ``It is evident that during the second quarter and first six months of 2000 the Company made tremendous strides in a return to profitability. Net assets as of June 30, 2000 were $7.2 million. This coupled with our return to the OTC Bulletin Board, gaining status as a fully-reporting entity, increasing gross profit, and the commencement of an aggressive implementation of our strategic plan, we believe will garner long term shareholder value.'' 

``I look forward to the Company's announced teleconference tomorrow which will be part of the UVGI's regular reporting process and demonstrates management's efforts to keep our loyal shareholder base informed,'' Nussen concluded. 

UVGI, a Delaware Corporation, through its wholly owned subsidiaries, is a jewelry designer, manufacturer and distributor. The Company's product line includes a wide assortment of 14-karat gold jewelry along with the newly added diamond, pearl and platinum jewelry lines. 

The Company is currently seeking to align itself with major Internet marketing and advertising entities to increase the brand awareness and drive traffic to the site. 

This press release contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities and Litigation Reform Act of 1995. Expression of future goals and similar expressions reflecting something other than historical fact involve risks and uncertainties. 

The actual results the Company achieves may differ materially from any forward-looking statements due to such risks and uncertainties. 


----------------------------------------------- 

Contact: 

 United Ventures Group, Inc.
         by
 DeMonte Associates
 Cynthia DeMonte, 212/473-3700
 cdemonte@demonte.com

------------------------------------
The Wallstreet Wizard Newsletter makes no recommendation about the securities profiled here and this is not a solicitation to buy any of these.  Management and staff may buy, sell or hold any of these securities mentioned. The material supplied is our opinion and is factual to the best of our knowledge and for information purposes only. For Free Trial to WallStreetU Newsletter: email to:    stockw1@excite.com  

This email is NOT spam. You  have  received  this email because either you,  or someone claming  tobe you has subscribed your  email address to this list. 
To unsubscribe, simply  email us at stockw2@excite.com  and type "remove from the wallstreet wizard list" in the subject,(include a  copy of this  email) and your address will  be removed from the newsletter email list

............................... 

MULTIPLY YOUR INVESTMENT DOLLAR WITH THIS GREAT STOCK OPPORTUNITY ---REVENUES AND GROSS PROFITS HAVE DOUBLED & INCOME IS ALMOST ONE MILLION DOLLARS-IT is About to EXPLODE in Share Price!

More BREAKING News and Information on UVGI 
 
http://quote.yahoo.com/q?s=UVGI.OB&d=v1
 
http://www.ragingbull.altavista.com/mboard/boards.cgi?board=UVGI&read=31576>http://www.ragingbull.altavista.com/mboard/boards.cgi?board=UVGI&read=31576
 
--

 


---




From owner-cardiors@hgmp.mrc.ac.uk  Mon Aug 28 20:00:15 2000
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From: Mary Wagner <mwagner@cellbio.emory.edu>
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Subject: Axon Instruments digidata 1200 board needed
Date: Mon, 28 Aug 2000 14:45:36 -0400
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Hi all...

Sorry for the crosspost. We had a computer stolen this weekend that
included the board to out
Axon Instruments Digidata 1200A. We have custom software and need to
replace this board -
does anyone have any idea where I can get my hands on a digidata 1200A
board? Axon no longer
makes the 1200 and has shipped their last 1200AE board.

Thanks for any info! Reply here or to my email:
mwagner@cellbio.emory.edu

Oh, and suggestions on where else to ask would be great!

Mary
______________________________________________
Mary Wagner, PhD
Department of Pediatrics
Emory University, Atlanta GA




From owner-cardiors@hgmp.mrc.ac.uk  Thu Aug 31 11:46:58 2000
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From: "Intermezzo" <intermezzo@mail.telepac.pt>
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Subject: European Pectens
Date: Thu, 31 Aug 2000 11:40:18 +0100
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We had recently released an interactiv cd-rom about the european pectens. In
this site you can reach some information about them and about the cd, and
how to order it.

visit us at

http://www.intermezzo.pt/pectens
http://www.intermezzo.pt/pectens
http://www.intermezzo.pt/pectens

more informations  intermezzo@intermezzo.pt


Recentemente lancámos um cd-rom interactivo intitulado "Vieiras - Pectens
da Europa". Aqui terá acesso a várias informações sobre estas pectens
podendo também proceder à encomenda do cd-rom.
visite-nos em:

http://www.intermezzo.pt/pectens
http://www.intermezzo.pt/pectens
http://www.intermezzo.pt/pectens

mais informações  intermezzo@intermezzo.pt







