From owner-cardiors@hgmp.mrc.ac.uk  Thu May  3 11:33:49 2001
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From: jmhoward@sprynet.com (James Michael Howard)
X-Newsgroups: bionet.biology.cardiovascular
Subject: A Difference in Drug Efficacy between Blacks and Whites (New England Journal of Medicine)
Date: Thu, 03 May 2001 10:32:19 GMT
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A Difference in Drug Efficacy between Blacks and Whites (New England Journal
of Medicine)

>From the latest "New England Journal of Medicine:"  "Conclusions. Enalapril
therapy is associated with a significant reduction in the risk of
hospitalization for heart failure among white patients with left ventricular
dysfunction, but not among similar black patients. This finding underscores
the need for additional research on the efficacy of therapies for heart
failure in black patients. (N Engl J Med 2001;344:1351-7.)"
(http://www.nejm.org/content/2001/0344/0018/1351.asp) 

I suggest differences in efficacy of enalapril between white and black
patients is due to effects of testosterone.  Blacks, males and females,
produce more testosterone than whites, males and females.  The effects of
testosterone on the effects of enalapril have been determined in
spontaneously hypertensive rats (Hypertension 2000 Jan;35(1 Pt 2):480-3):
"androgens [testosterone] promote the exacerbation of hypertension in male
SHR via a mechanism involving the renin-angiotensin system."

James Michael Howard
Fayetteville, Arkansas, U.S.A.


From owner-cardiors@hgmp.mrc.ac.uk  Thu May  3 14:52:56 2001
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From: "Tony Ullo" <ullo@echoes.net>
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Subject: Ultrasound Sales
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From owner-cardiors@hgmp.mrc.ac.uk  Tue May  8 20:15:20 2001
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From owner-cardiors@hgmp.mrc.ac.uk  Sat May 12 18:35:46 2001
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From: justone@techspot.com
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From owner-cardiors@hgmp.mrc.ac.uk  Sun May 13 06:05:46 2001
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From: l53l5l34k30@excite.com (You'll Love This)
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Subject: "This is a very pleasant surprise"!!!
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From owner-cardiors@hgmp.mrc.ac.uk  Sun May 13 18:50:57 2001
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From: redfalcon@adelphia.net
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From owner-cardiors@hgmp.mrc.ac.uk  Mon May 14 09:51:01 2001
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From: genetalk@entelechon.com
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Subject: Public discussion board for gene and bio synthesis
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-----------------------------------------------------
If you do not want to receive emails from Entelechon,
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From owner-cardiors@hgmp.mrc.ac.uk  Tue May 15 01:35:52 2001
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From owner-cardiors@hgmp.mrc.ac.uk  Wed May 16 13:50:57 2001
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Anybody know where TOS stands for ?

pls reply to derma22@zonnet.nl




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From owner-cardiors@hgmp.mrc.ac.uk  Sun May 20 03:50:57 2001
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I think we get the point now, ok?
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> please contact:  smisba@west.net



From owner-cardiors@hgmp.mrc.ac.uk  Sun May 20 20:36:21 2001
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From owner-cardiors@hgmp.mrc.ac.uk  Mon May 21 13:06:15 2001
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From: "Barak Akabayov" <akabayb@mail.biu.ac.il>
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Dear all:



Recently it is obvious that reperfusion following ischemia in heart muscle
terminates via apoptosis.

My problem as a young student is why does the programmed cell death take
place in ischemic heart diseases? Is it for heart function maintenance by
eliminating the disturbances for membrane potential, or else?



Much appreciate any help


--
Barak Akabayov
Bar-Ilan University
Ramat-Gan
Israel
akabayb@mail.biu.ac.il





From owner-cardiors@hgmp.mrc.ac.uk  Thu May 24 05:21:16 2001
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Hi, the answer for your question is not just simple.
The words 'programmed cell death' doesn't mean the cell will live for
scheduled time and die. Apoptotic process is very complex and affected by a
great deal of toxins, proteins, enzymes or so.
I'd like to say that apoptosis is not programmed cell death but program of
cell death just like necrosis.

You will find other prominent information on apoptosis in medical article
searching engines which would add your questions to confusion.

Be good.
DH Kim



From owner-cardiors@hgmp.mrc.ac.uk  Thu May 24 17:51:15 2001
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From: jmhoward@sprynet.com (James Michael Howard)
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Subject: Peripartum Cardiomyopathy and Dehydroepiandrosterone
Date: Thu, 24 May 2001 16:43:40 GMT
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Peripartum Cardiomyopathy and Dehydroepiandrosterone
(N Engl J Med 2001;344:1567-71)

This is my "letter to the editor" to the "New England Journal of Medicine."
I thought some, here, may be interested in reading it.  (The abstract of the
article follows.)

James Michael Howard
Fayetteville, Arkansas, U.S.A.

"The findings of Elkayam, et al., may be explained by reduced
dehydroepiandrosterone (DHEA) in subsequent pregnancies.  DHEA declines
"markedly and significantly" following a first pregnancy (J Clin Endocrinol
Metab 1987; 64: 111-8).  DHEA levels in term nulliparous women requiring
pharmacologic augmentation are significantly lower than in women who
progress spontaneously through labor (Obstet Gynecol 1996; 88: 56-9).  DHEA
is consistently connected to systolic blood pressure (Am J Hypertens 1999;
12: 1140-3) and "plasma levels of DHEAS are decreased in patients with CHF
in proportion to its severity" (J Clin Endocrinol Metab 2000; 85: 1834-40).

I suggest the conclusions of Elkayam, et al., represent a group of low DHEA
women whose first pregnancies further reduced their DHEA and, therefore,
associated peripartum cardiomyopathy."


This is the NEJM article:

"Maternal and Fetal Outcomes of Subsequent Pregnancies in Women with
Peripartum Cardiomyopathy"

Uri Elkayam, Padmini P. Tummala, Kalpana Rao, Mohammed W. Akhter, Ilyas S.
Karaalp, Omar R. Wani, Afshan Hameed, Israel Gviazda, Avraham Shotan

Abstract

Background. Peripartum cardiomyopathy is a rare but sometimes fatal form of
heart failure. Little is known about the outcomes of subsequent pregnancies
in women who have had the disorder.
Methods. Through a survey of members of the American College of Cardiology,
we identified 44 women who had had peripartum cardiomyopathy and had a total
of 60 subsequent pregnancies. We then reviewed the medical records of these
women and interviewed the women or their physicians.

Results. Among the first subsequent pregnancies in the 44 women, 28 occurred
in women in whom left ventricular function had returned to normal (group 1)
and 16 occurred in women with persistent left ventricular dysfunction (group
2). The pregnancies were associated with a reduction in the mean (±SD) left
ventricular ejection fraction both in the total cohort (from 49±12 percent
to 42±13 percent, P<0.001) and in each group separately (from 56±7 percent
to 49±10 percent in group 1, P=0.002; and from 36±9 percent to 32±11 percent
in group 2, P=0.08). During these pregnancies, symptoms of heart failure
occurred in 21 percent of the women in group 1 and 44 percent of those in
group 2. The mortality rate was 0 percent in group 1 and 19 percent in group
2 (P=0.06). In addition, the frequency of premature delivery was higher in
group 2 (37 percent vs. 11 percent), as was that of therapeutic abortions
(25 percent vs. 4 percent).

Conclusions. Subsequent pregnancy in women with a history of peripartum
cardiomyopathy is associated with a significant decrease in left ventricular
function and can result in clinical deterioration and even death. (N Engl J
Med 2001;344:1567-71.)"


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From owner-cardiors@hgmp.mrc.ac.uk  Wed May 30 06:06:17 2001
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From: "peterson" <peterson@virtuontech.com>
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Subject: I wanna know about "sintrom"
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anybody know about sintrom , I wanna know more about this drug ,please send
the infomation to my email
peterson@virtuontech.com



