From owner-chromosomes@net.bio.net Mon Aug 01 23:00:00 1994 Path: biosci!agate!ihnp4.ucsd.edu!munnari.oz.au!newsroom.utas.edu.au!mg1_43.med.utas.edu.au!user From: sd_chin@postoffice.SandyBay.utas.edu.au (Devika Chin) Newsgroups: bionet.genome.chromosomes Subject: Haldane's Law Followup-To: bionet.genome.chromosomes Date: 27 Jul 1994 22:47:05 GMT Organization: University of Tasmania, Australia Lines: 12 Distribution: world Message-ID: NNTP-Posting-Host: mg1_43.med.utas.edu.au Hello, I would be most obliged if anybody can explain what heterogameity means, as given in Haldane's law. Does it merely mean that the hybrid offspring got a particular sex chromosome (either X or Y) from one parent and an autosomal gene from the other that causes an imbalance? I am really confused. Any help will be appreciated. Thanks, Devika. sd_chin@Postoffice.SandyBay.utas.edu.au From owner-chromosomes@net.bio.net Mon Aug 01 23:00:00 1994 Path: biosci!MCZ.HARVARD.EDU!dmw From: dmw@MCZ.HARVARD.EDU (Dan Weinreich) Newsgroups: bionet.genome.chromosomes Subject: Re: Haldane's Law Date: 2 Aug 1994 06:01:46 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 37 Sender: daemon@net.bio.net Distribution: world Message-ID: References: Reply-To: Dan Weinreich NNTP-Posting-Host: net.bio.net In diploid individuals, offspring get one of each chromosome from each parent, giving it a total of two of each chromosomes. In the case of the sex chromosome, of which there are generally two easily distinguishable forms (Carothers described sex chromosomes in male grasshoppers as "heteromorphic" pairs in 1913), offspring again get one from each parent, but homogametic individuals get similar chromosomes while heterogametic individuals get dissimilar chromosomes. The foregoing applies to (almost) all diploid species, and has nothing to do with hybrid crosses. In mammals and among most insects, heterogamous individuals are males (that is, they're the ones who produce sperm) and homogamous individuals are females. But in butterflies as well as in birds, it is the homogamous individual which are male and the heterogamous which are female. In some hybrid crosses, all offspring are "sick," i.e. dead, rare or sterile, but in many such crosses, only one sex is affected. Haldane's Rule states that in such cases, it is always the heterogametic sex which is so affected. If you're interested in the genetics of this phenomenon, you might read Jerry Coyne, e.g. Nature 369:189 May 19, 1994, or the chapter he and H. Allen Orr wrote in _Speciation_and_its_Consequences_. Regards, Dan. ------------------------------------------------------------------- Dan Weinreich email: dmw@mcz.harvard.edu Harvard University usmail: 26 Oxford Street Museum of Comparative Zoology Cambridge, MA 02138 voice: (617) 495-1954 fax: (617) 495-5667 ------------------------------------------------------------------- From owner-chromosomes@net.bio.net Tue Aug 02 23:00:00 1994 Path: biosci!agate!howland.reston.ans.net!pipex!doc.ic.ac.uk!sun.rhbnc.ac.uk!not-for-mail From: uhaa022@sun.rhbnc.ac.uk (Mark Brady mark@sun.rhbnc.ac.uk) Newsgroups: bionet.genome.chromosomes Subject: chromosome 15 Date: 3 Aug 1994 10:58:50 +0100 Organization: University of London, Royal Holloway College. Lines: 17 Message-ID: <31npoq$4al@sun.rhbnc.ac.uk> NNTP-Posting-Host: sun.rhbnc.ac.uk X-Newsreader: TIN [version 1.2 PL2] Hello, I am scouring for sources on information concerning chromome 15, specifically consequences of a condition known as di-centric chromosome 15. I am a non biologist,I am looking for help for my sister who has been told her son, my Nephew has this condition, but has not been told much else. For example, recently we have been told he has "macolopathy" - bad vision in the centre of his eye. Would this be related ? If anyone has sources to hand, I would appreciate email. My sister is very keen to understand what is in store for her. Regards, Mark mark@sun.rhbnc.ac.uk From owner-chromosomes@net.bio.net Fri Aug 05 23:00:00 1994 Path: biosci!agate!usenet.ins.cwru.edu!cleveland.Freenet.Edu!br640 From: br640@cleveland.Freenet.Edu (Jason A. Best) Newsgroups: bionet.genome.chromosomes Subject: careers in geneticism Date: 6 Aug 1994 02:06:33 GMT Organization: Case Western Reserve University, Cleveland, Ohio (USA) Lines: 5 Message-ID: <31ur79$gas@usenet.INS.CWRU.Edu> NNTP-Posting-Host: kanga.ins.cwru.edu OK, I'm only a sophomore in high school, but I'm looking for any sorts of information, or places I can contact about careers dealing with genetics... many thanks! -ocean -- From owner-chromosomes@net.bio.net Tue Aug 09 23:00:00 1994 Path: biosci!internet!biosci!not-for-mail From: kristoff (David Kristofferson) Newsgroups: bionet.genome.chromosomes Subject: UNSUBSCRIBING, BIOSCI ARCHIVES, ADDRESS DATABASE & BIOSCI FAQ Date: 10 Aug 1994 02:00:17 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 322 Sender: daemon@net.bio.net Distribution: world Message-ID: <199408100900.CAA14400@net.bio.net> NNTP-Posting-Host: net.bio.net Four important items follow: How to cancel e-mail subscriptions to BIOSCI newsgroups, BIOSCI archive searching, the BIOSCI FAQ, and the BIOSCI User Address Directory form. 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Thanks again for your cooperation! --------------- please cut here and return portion below --------------- New information or Update to old record (enter N or U): date (DD-MM-YY): first name: middle initial: family name: job title: e-mail address: e-mail network: phone number: FAX number: institution: address1: address2: address3: city: state/province: country: postal code: research interest: research interest: comment: comment: comment: comment: comment: From owner-chromosomes@net.bio.net Wed Aug 10 23:00:00 1994 Path: biosci!agate!howland.reston.ans.net!gatech!newsfeed.pitt.edu!uunet!munnari.oz.au!newsroom.utas.edu.au!librarymac6h235.its.utas.edu.au!user From: yld_tan@sandybay.utas.edu.au () Newsgroups: bionet.genome.chromosomes Subject: klinefelter's syndrome Followup-To: bionet.genome.chromosomes Date: 11 Aug 1994 04:53:23 GMT Organization: University of Tasmania, Australia. Lines: 7 Message-ID: NNTP-Posting-Host: librarymac6h235.its.utas.edu.au I am seeking information on this syndrome and its resulting impact if any on sexual orientation. I have a friend who has this condition and is experiencing confusion sexually. He seems to swing between homosexual to heterosexual to asexual feelings constantly. He is 26 years ago and the state of mind seems consistent with a pubescent male. Is there any correlation between this syndrome and sexuality? From owner-chromosomes@net.bio.net Wed Aug 10 23:00:00 1994 Path: biosci!agate!howland.reston.ans.net!EU.net!Austria.EU.net!newsfeed.ACO.net!swidir.switch.ch!univ-lyon1.fr!jussieu.fr!nef.ens.fr!oko!lacroix From: lacroix@ens.fr (Gerard LACROIX) Newsgroups: bionet.genome.chromosomes Subject: chromosomal arrangements Date: 11 Aug 1994 00:38:42 GMT Organization: Laboratoire d'Ecologie - Ecole Normale Superieure, Paris, France Lines: 15 Distribution: world Message-ID: <32brui$d9r@nef.ens.fr> Reply-To: lacroix@ens.fr NNTP-Posting-Host: oko.ens.fr Keywords: chromosomal morphologies & karyotypes Is this a very recent group or what? I only see two articles here. Never mind, maybe some day I get some usefull information. I'm working on the evolution of karyotypes (assuming that the possible importance of the "morphology" of chromosomal sets has been neglected for too long), so if anybody can give me a good reference for a review OR ANY INFO ABOUT THE KARYOTYPE of the animal or plant he/she is working on, such as number and types of chromosomes and/or estimated DNA length, it will be of much help. Thank's in advance Gerard Lacroix Laboratoire d'ecologie Ecole Normale Superieure Paris From owner-chromosomes@net.bio.net Wed Aug 10 23:00:00 1994 Path: biosci!agate!howland.reston.ans.net!gatech!newsfeed.pitt.edu!uunet!munnari.oz.au!newsroom.utas.edu.au!librarymac6h235.its.utas.edu.au!user From: yld_tan@sandybay.utas.edu.au () Newsgroups: bionet.genome.chromosomes Subject: klinefelter's syndrome Followup-To: bionet.genome.chromosomes Date: 11 Aug 1994 05:02:53 GMT Organization: University of Tasmania, Australia. Lines: 5 Message-ID: NNTP-Posting-Host: librarymac6h235.its.utas.edu.au I'm seeking information about klinefelter's syndrome and the correlation (if any) between it and sexual orientation. I have a friend who is experiencing constant confusion in his sexual identity. In any one day he says he can experience homosexual, heterosexual, and asexual tendencies. He is 26 years old. From owner-chromosomes@net.bio.net Sun Aug 14 23:00:00 1994 Path: biosci!agate!msuinfo!harbinger.cc.monash.edu.au!ctl-103-05.cc.monash.edu.au!jdkol1 From: jdkol1@MFS03.cc.monash.edu.au (Jeremy Kolt) Newsgroups: bionet.genome.chromosomes Subject: Please help with translocation Date: Mon, 15 Aug 1994 04:51:17 GMT Organization: Monash University Lines: 20 Message-ID: NNTP-Posting-Host: ctl-103-05.cc.monash.edu.au Hi, I am a third year medical student studying Medical Genetics. If anyone can help me with info to an assignment, it would be much appreciated. I have a cytogenetic profile of an amniocentesis from a mother with a history of recurrent miscarriage. The result is a balanced 9/20 translocation, in which the long arms of one chromosome 20 have been joined to the terminal ends of the long arms of one chromosome 9. Would this fetus be viable? I suspect that previous aborted fetuses would have been unbalanced translocations - is this correct? What are the phenotypic effects of missing pieces of the terminal end of 20q? What are the phenotypic effects of 9/20 translocations? What is the frequncy of this abnormality? What is the recurrent risk for future pregnancies? I hope someone can help, Thanks in advance, Jeremy Kolt, jdkol1@mfs03.cc.monash.edu.au From owner-chromosomes@net.bio.net Mon Aug 15 23:00:00 1994 Path: biosci!bcm!cs.utexas.edu!usc!elroy.jpl.nasa.gov!sdd.hp.com!saimiri.primate.wisc.edu!news.doit.wisc.edu!medgen.waisman.wisc.edu!kirkpatrick From: kirkpatrick@medgen.waisman.wisc.edu (Susan J. Kirkpatrick) Newsgroups: bionet.genome.chromosomes Subject: RE: Please help with translocation Date: 16 AUG 94 19:00:07 GMT Organization: Waisman Center, University of Wisconsin-Madison Lines: 6 Message-ID: <16AUG94.19000765@medgen.waisman.wisc.edu> References: NNTP-Posting-Host: don.waisman.wisc.edu regarding the 9/20 translocation--a good medical genetics textbook can help you with the basics of sorting out translocations and predicting possible outcomes. you'd have to do a search (medline can pull out chromosome info under chromosomes, human, pair ___) to attempt to find literature about frequency and phenotype. Does your medical center have a genetic counselor whom you can consult for help? From owner-chromosomes@net.bio.net Tue Aug 16 23:00:00 1994 Newsgroups: bionet.genome.chromosomes Path: biosci!agate!howland.reston.ans.net!spool.mu.edu!torn!nott!cunews!freenet.carleton.ca!FreeNet.Carleton.CA!ah335 From: ah335@FreeNet.Carleton.CA (Glen Ashton) Subject: Rh- factor Message-ID: Sender: news@freenet.carleton.ca (Usenet News Admin) Reply-To: ah335@FreeNet.Carleton.CA (Glen Ashton) Organization: The National Capital FreeNet Date: Wed, 17 Aug 1994 17:55:28 GMT Lines: 12 I am taking a WAG as to where to post this question - if you have any suggestions please email me (TIA). A medical doctor claims that two Rh+ parents (i.e. blood type) cannot have a Rh- child. From the few sources I have been able to find that talk about this it seems this is false, though I would appreciate if one could either confirm this, or even better, let me know of a definite source on this issue that I could refer the doctor to. Glen From owner-chromosomes@net.bio.net Tue Aug 16 23:00:00 1994 Path: biosci!MENDEL.LLNL.GOV!greg From: greg@MENDEL.LLNL.GOV Newsgroups: bionet.genome.chromosomes Subject: Re: Rh- factor Date: 17 Aug 1994 11:49:06 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 36 Sender: daemon@net.bio.net Distribution: world Message-ID: <9408171848.AA27866@mendel.llnl.gov> Reply-To: Greg Lennon NNTP-Posting-Host: net.bio.net This question can be answered fairly easily by checking the Online Mendelian Inheritance in Man (OMIM) database ; in this case, look up entry 268150. Access to the database is available via gopher at gopher.gdb.org; WWW at http://gdbwww.gdb.org; or via IRx by obtaining an account for GDB/OMIM (contact help@gdb.org for an account to access data in this manner). Greg Lennon Human Genome Center Lawrence Livermore National Laboratory Livermore CA 94550 > From BIOSCI-REQUEST@net.bio.net Wed Aug 17 11:32:29 1994 > To: biochrom@net.bio.net > From: ah335@FreeNet.Carleton.CA (Glen Ashton) > Subject: Rh- factor > Sender: news@FreeNet.Carleton.CA (Usenet News Admin) > Reply-To: ah335@FreeNet.Carleton.CA (Glen Ashton) > Date: Wed, 17 Aug 1994 17:55:28 GMT > Content-Length: 452 > > > I am taking a WAG as to where to post this question - if you have any > suggestions please email me (TIA). > > A medical doctor claims that two Rh+ parents (i.e. blood type) cannot have > a Rh- child. From the few sources I have been able to find that talk > about this it seems this is false, though I would appreciate if one could > either confirm this, or even better, let me know of a definite > source on this issue that I could refer the doctor to. > > Glen > > > From owner-chromosomes@net.bio.net Wed Aug 17 23:00:00 1994 Path: biosci!agate!howland.reston.ans.net!vixen.cso.uiuc.edu!news.uoregon.edu!netnews.nwnet.net!news.u.washington.edu!news From: dadler@u.washington.edu (David Adler) Newsgroups: bionet.genome.chromosomes Subject: Re: Rh- factor Date: 18 Aug 1994 05:16:22 GMT Organization: University of Washington Lines: 47 Message-ID: <32uqr6$b4p@news.u.washington.edu> References: Reply-To: dadler@u.washington.edu NNTP-Posting-Host: koko.pathology.washington.edu In article ah335@FreeNet.Carleton.CA (Glen Ashton) writes: .. > A medical doctor claims that two Rh+ parents (i.e. blood type) cannot > have a Rh- child. From the few sources I have been able to find that > talk about this it seems this is false, though I would appreciate if one > could either confirm this, or even better, let me know of a definite > source on this issue that I could refer the doctor to. .. and In article <9408171848.AA27866@mendel.llnl.gov> greg@MENDEL.LLNL.GOV writes: > > This question can be answered fairly easily by checking the Online > Mendelian Inheritance in Man (OMIM) database ; in this case, look > up entry 268150. Funny but I read the question and immediately thought 'check OMIM' and then read Greg's response and thought 'ok another question taken care of...' But realized I wasn't quite sure of the answer - I guessed Rh- (rh/rh) child is possible from parents who are both Rh+ if parents are heterozygotes (Rh/rh). Upon reading the OMIM entry I found the situation more complex - a multiple allele system with as yet unresolved genetic questions. Good reading but in fact does not answer the original question, at least not directly and simply. So I turn to the first genetics book that falls off my shelf, this ones a little dusty: Principles of Genetics, Sinnot, Dunn and Dobzhansky, 5th edition, 1958, page 119: "...Thus where a child is cde/cde (r/r), although neither parent is, both parents must be heterozygous for this allele as in the mating [CDe(R1)/cde(r)] x [cDE(R2)/cde(r)]." So parents that are both "Rh+" *can* have an "Rh-" child. Curious about the sources on which the medical doctor's claim is based. Interesting also in this exploration is that the issues discussed in the 1958 text remain unresolved in the OMIM entry. David -- David A. Adler Pathology SM-30 University of Washington Seattle, WA 98195 (206) 543-0716 (phone) (206) 543-3644 (fax) "Science is nothing but trained and organized common sense" T.H.Huxley From owner-chromosomes@net.bio.net Mon Aug 29 23:00:00 1994 Newsgroups: bionet.genome.chromosomes Path: biosci!galaxy.ucr.edu!ihnp4.ucsd.edu!agate!howland.reston.ans.net!EU.net!Austria.EU.net!newsfeed.ACO.net!swidir.switch.ch!news.unige.ch!divsun!mike From: mike@divsun.unige.ch (Mike Morris) Subject: Medical Genetics Lab Management s/ware Message-ID: <1994Aug30.125447.14920@news.unige.ch> Sender: usenet@news.unige.ch Organization: University of Geneva, Switzerland Date: Tue, 30 Aug 1994 12:54:47 GMT Lines: 26 (This may not be quite the right place to post this message- but the information is very important to us!) We want to install a computer system to manage our Medical Genetics DNA and Cytogenetics diagnostic laboratories, plus perhaps also the clinical consultation service. The package should handle at least sample reception, labelling, and results; anything else would be a bonus. We are not precommitted to any one system, but networking is essential and a multisystem approach would be ideal. Obviously we could develop our own database, but we would rather not reinvent the wheel (having done so many times already...). Does anybody have experience of such packages, positive or negative? Please answer by email; if I get anwers, I will put a compiled answer back on the News. (Even replies from commercial companies would be appreciated, for once!) Thanks in advance, ******************************************************************* Michael Morris PhD Division of Medical Genetics tel (Switzerland) (22) 702.56.94 CMU, University of Geneva fax (Switzerland) (22) 702.57.06 Geneva, Switzerland email mike@medsun.unige.ch From owner-chromosomes@net.bio.net Tue Aug 30 23:00:00 1994 Path: biosci!galaxy.ucr.edu!ihnp4.ucsd.edu!munnari.oz.au!newsroom.utas.edu.au!NewsWatcher!user From: dp_tys@Postoffice.SandyBay.utas.edu.au (Derek Tys) Newsgroups: bionet.genome.chromosomes Subject: test Followup-To: bionet.genome.chromosomes Date: 31 Aug 1994 06:30:02 GMT Organization: University of Tasmania, Australia. Lines: 1 Message-ID: NNTP-Posting-Host: 131.217.17.16 just testing From owner-chromosomes@net.bio.net Tue Aug 30 23:00:00 1994 Path: biosci!waite.adelaide.edu.au!cford From: cford@waite.adelaide.edu.au Newsgroups: bionet.genome.chromosomes Subject: unsubscribe Date: 31 Aug 1994 00:20:28 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 3 Sender: daemon@net.bio.net Distribution: world Message-ID: <01HGKE5O2A7Q00011E@hermes.itd.adelaide.edu.au> NNTP-Posting-Host: net.bio.net Please UNSUBSRCIBE me from this mailing list. Thank you very much. Chris ford. From owner-chromosomes@net.bio.net Tue Aug 30 23:00:00 1994 Path: biosci!galaxy.ucr.edu!ihnp4.ucsd.edu!munnari.oz.au!newsroom.utas.edu.au!NewsWatcher!user From: dp_tys@Postoffice.SandyBay.utas.edu.au (Derek Tys) Newsgroups: bionet.genome.chromosomes Subject: klinefelter's syndrome Followup-To: bionet.genome.chromosomes Date: 31 Aug 1994 06:35:32 GMT Organization: University of Tasmania, Australia. Lines: 4 Message-ID: NNTP-Posting-Host: 131.217.17.16 I am seeking information on the correlation - if any - between this syndrome and sexual identity and orientation. From owner-chromosomes@net.bio.net Wed Aug 31 23:00:00 1994 Path: biosci!DXI.NIH.GOV!goldman%bchem.dnet From: goldman%bchem.dnet@DXI.NIH.GOV Newsgroups: bionet.genome.chromosomes Subject: klinefelter's syndrome - Reply Date: 31 Aug 1994 20:10:31 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 5 Sender: daemon@net.bio.net Distribution: world Message-ID: <9409010310.AA27080@dxi.nih.gov> NNTP-Posting-Host: net.bio.net Although there have been some reports of an association between Klinefelter's syndrome and male sexuality, the data is sparse and the interpretations conflicting. Simon LeVays book "The Sexual Brain" summarizes current findings. From owner-chromosomes@net.bio.net Wed Aug 31 23:00:00 1994 Path: biosci!DXI.NIH.GOV!goldman%bchem.dnet From: goldman%bchem.dnet@DXI.NIH.GOV Newsgroups: bionet.genome.chromosomes Subject: klinefelter's syndrome - Reply Date: 31 Aug 1994 20:09:53 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 5 Sender: daemon@net.bio.net Distribution: world Message-ID: <9409010309.AA27069@dxi.nih.gov> NNTP-Posting-Host: net.bio.net Although there have been some reports of an association between Klinefelter's syndrome and male sexuality, the data is sparse and the interpretations conflicting. Simon LeVays book "The Sexual Brain" summarizes current findings.