From owner-chromosomes@net.bio.net Mon May 01 23:00:00 1995 Path: biosci!daresbury!trane.uninett.no!nntp.uio.no!nac.no!Norway.EU.net!EU.net!howland.reston.ans.net!vixen.cso.uiuc.edu!newsrelay.iastate.edu!bvc.edu!yuqian From: yuqian@bvc.edu (Suicidal Freshman) Newsgroups: bionet.genome.chromosomes,bionet.immunology Subject: New Dedicated Bio-tech/science/chem BBS Message-ID: <1995May2.123859.10892@bvc.edu> Date: 2 May 95 12:38:59 CDT Organization: Buena Vista College, Storm Lake, IA Lines: 27 Xref: biosci bionet.genome.chromosomes:568 bionet.immunology:3999 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% A NEW BBS IS ONLINE AND NEEDS PEOPLE LIKE YOU TO HELP IT PROSPER The IDT Online Information System is now up and running and needs intelligent users such as yourselves. Anyone interested in Chemistry or Biology or any twist of the two is more than welcome. If you are a user of Oligonucleotides, there is an online order system that allows you to place your order directly into the production facility for 48 hour turnaround. THERE IS ABSOLUTELY NO CHARGE FOR USAGE. YOU DO NOT HAVE TO BE A CUSTOMER TO USE THE SYSTEM Just a sample of some of the discussion forums: Parsitology Classifieds Employment Chemical Engineering Computer Software Biochemistry Programming Molecular Medicine Genetics Organic Chemistry Oligo Design Scientific Humor BioPhysics Cell Biology Internet Topics Biomed Engineering Late Breaking News Immunology NeuroScience Suggestions The system is in place, and we are looking for good users, and a few Forum Moderators, so: Check it out: telnet 204.71.106.202 or telnet idtdna.com %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% From owner-chromosomes@net.bio.net Tue May 02 23:00:00 1995 Path: biosci!rutgers!gatech!howland.reston.ans.net!news.sprintlink.net!uunet!newsflash.concordia.ca!news.mcgill.ca!usenet From: Graham Dellaire Newsgroups: bionet.genome.chromosomes Subject: Re: Fragile X Syndrome Date: 3 May 1995 02:17:43 GMT Organization: McGill University Computing Centre Lines: 13 Message-ID: <3o6p47$l35@sifon.cc.mcgill.ca> References: <3nhvbi$2ap@newsbf02.news.aol.com> NNTP-Posting-Host: c-03.das.mcgill.ca X-Newsreader: AIR News 3.X (SPRY, Inc.) > arf123@aol.com (ARF123) writes: > I am seeking additional information on Fragile X Syndrome. Prefer recent > as possible. Post here or e-mail at ARF123@AOL.com > >>>> Are you familiar with Medline, or do you have access to such a service? It would be much easier if you could use such a service. All you have to do then is type the key words "fragile X syndrome" and you would find more than enough information. G. From owner-chromosomes@net.bio.net Tue May 02 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!gatech!bloom-beacon.mit.edu!panix!usenet From: Gary Welz Newsgroups: bionet.genome.chromosomes Subject: Discussion of Genome as Program Date: 3 May 1995 17:03:47 GMT Organization: PANIX Public Access Internet and Unix, NYC Lines: 965 Message-ID: <3o8d1j$hc3@news.panix.com> NNTP-Posting-Host: 166.84.254.106 Mime-Version: 1.0 Content-Type: multipart/mixed; boundary="-------------------------------318973830089" X-Mailer: Mozilla 1.1b3 (Macintosh; I; 68K) X-URL: news:bionet.genome.chromosomes This is a multi-part message in MIME format. ---------------------------------318973830089 Content-Transfer-Encoding: 7bit Content-Type: text/plain; charset=iso-8859-1 Attached is the discussion of an earlier posting of mine: "Can the Genome be Thought of as a Computer Program" -Gary Welz ---------------------------------318973830089 Content-Transfer-Encoding: base64 Content-Type: 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Path: biosci!rutgers!gatech!bloom-beacon.mit.edu!panix!usenet From: Gary Welz Newsgroups: bionet.genome.chromosomes Subject: Re: Discussion of Genome as Program - Remove error in sending Date: 3 May 1995 17:07:22 GMT Organization: PANIX Public Access Internet and Unix, NYC Lines: 5 Message-ID: <3o8d8b$hkg@news.panix.com> References: <3o8d1j$hc3@news.panix.com> NNTP-Posting-Host: 166.84.254.106 Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1b3 (Macintosh; I; 68K) To: gwelz@panix.com X-URL: news:3o8d1j$hc3@news.panix.com Remove this. There was an error in sending -Gary From owner-chromosomes@net.bio.net Tue May 02 23:00:00 1995 Path: biosci!rutgers!gatech!howland.reston.ans.net!torn!ccshst05.cs.uoguelph.ca!ccshst01.cs.uoguelph.ca!cclaus From: cclaus@uoguelph.ca (Carol L Claus) Newsgroups: bionet.genome.chromosomes Subject: sequence or info of Rubinstein-Tabi Syndrome Date: 3 May 1995 19:41:47 GMT Organization: University of Guelph Lines: 12 Message-ID: <3o8m9r$8cc@ccshst05.cs.uoguelph.ca> NNTP-Posting-Host: ccshst01.cs.uoguelph.ca X-Newsreader: TIN [version 1.2 PL2] I am seeking information regarding the location of the chromosomal aberration which produces the syndrome known as Rubinstein-Tabi Syndrome, otherwise referred to as Broad Thumb Syndrome. Any assistance in this area would be greatly appreciated. Please reply to: cclaus@uoguelph.ca Many Thanks C. L. Claus Dept. of Molecular Biology and Genetics University of Guelph Guelph, Ontario Canada From owner-chromosomes@net.bio.net Fri May 05 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!mojo.eng.umd.edu!cs.umd.edu!news.umbc.edu!haven.umd.edu!cville-srv.wam.umd.edu!usenet From: lexus@umd.edu (PG2User) Newsgroups: bionet.genome.chromosomes Subject: the bell curve Date: 6 May 1995 02:16:57 GMT Organization: University of Maryland College Park Lines: 38 Sender: -Not-Authenticated-[4101] Message-ID: <3oem6p$6mr@cville-srv.wam.umd.edu> NNTP-Posting-Host: mac31pg2.wam.umd.edu X-Posted-From: InterNews 1.0.1@mac31pg2.wam.umd.edu Xdisclaimer: No attempt was made to authenticate the sender's name. Hi. I am an English graduate student doing a paper on The Bell Curve and am solicting responses. I have selected this news group because I am particularly interested in what the genetic community thinks of this book. Initially, I chose to review this book because I was so outraged by its premise that cognitive abilities among races are fixed. Though the idea of I.Q. among races as genetically predetermined seems inane and ridiculous, the fact that 400,000 copies of this book were actually sold, putting The Bell Curve on the best seller's list, deeply distrubed me. My fear is that lay people will view this book as an academic treatise. After three days of very basic research, I could not understand why this book was even being read. First, scientifically speaking, how could Herrnstein and Murray even define race especially now in light of Cavalli Sforza's work that maps the human species as a hybrid of races. Also, I was under the impression that when discussing heritability factors, difference in terms of cognitive abilities can only be measured between individuals, not groups of people. Though Herrnstein and Murray assert a scientific premise, I failed to see the scientific evidence. There are currently over 117 articles on The Bell Curve, however, most of them are written by lay people like myself and most were written out of extreme emotion. Though I was relieved to read Stephen Gould's critiques, I am concerned by the lack of response from the scientific community since the book is supposedly written from a scientific perspective. After talking to some professors in the area of population genetics , I thought that the lack of response was due to its ridiculous topic or simply because academics are just tired of reading disingenuous books (i.e. Jensen, Rushton, etc.). Personally, I found it increasingly difficult to give this book any sort of credence especially after examining their reference: -weak correlation coefficients -researchers associated with Pioneer Fund. What are your views about this book? Can you find any scientific merit in their research? What about the authors' notion of race? Lastly, if you have a favorable read of this book please respond. I would appreciate your response. My U Mail address is Lexus@wam.umd.edu . Thank You. From owner-chromosomes@net.bio.net Fri May 05 23:00:00 1995 Path: biosci!agate!sunsite.doc.ic.ac.uk!daresbury!not-for-mail From: mln Newsgroups: bionet.genome.chromosomes Subject: Training in Biotechniques (fwd) Date: 6 May 1995 08:58:43 +0100 Lines: 28 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <3ofa7j$qi9@mserv1.dl.ac.uk> Original-To: biochrom@dl.ac.uk Dear Sir/Madam, I am a chemist -cum- crystallographer. I would like to have hands on experience on biotechniques - This is towards my aim on anti-cancer drug designing. DNA/Proteins - Extraction, Purification Gene Identification, Isolation, Characterization Cell culture Those who are interested in providing this training by means of offering a suitable research position, may please contact me for getting more details, cv etc... Thanking you sincerely yours M. Lakshmi Naryanan Department of Structural Biology Weizmann Institute of Science Rehovot 76100 ISRAEL csmln@weizmann.weizmann.ac.il From owner-chromosomes@net.bio.net Sat May 06 23:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!uunet!news.inhouse.compuserve.com!news.production.compuserve.com!news From: Cynthia Helphingstine <76657.42@CompuServe.COM> Newsgroups: bionet.cellbiol,bionet.general,bionet.genome.chromosomes,bionet.molbio.hiv,bionet.molbio.methds-reagnts Subject: Customers of Core DNA Sequencing La Date: 7 May 1995 17:34:24 GMT Organization: The Biotron Group Lines: 11 Message-ID: <3oj0b0$f60$1@mhadg.production.compuserve.com> Xref: biosci bionet.cellbiol:2209 bionet.general:15079 bionet.genome.chromosomes:575 bionet.molbio.hiv:1152 bionet.molbio.methds-reagnts:28026 If you manage a lab in the USA that sends DNA samples to a core lab for sequencing, we would like to have you participate in a market research study we are doing. By answering our questions, you will be contributing to the availability of better sequencing products and equipment for all of us. If you would like to participate in this study, please send your name, phone number and the best time of day to reach you to 76657.42@compuserve.com Our questions will take about 10 minutes. Your responses will be viewed in aggregate only and we will not release your phone number. If you prefer, you can call us at 1-800-592-9575 after 2:00 am CDT on Monday May 8. Thank you! From owner-chromosomes@net.bio.net Sat May 06 23:00:00 1995 Path: biosci!agate!newsxfer.itd.umich.edu!gatech!bloom-beacon.mit.edu!panix!usenet From: Gary Welz Newsgroups: bionet.genome.chromosomes Subject: Genome as Program II: b-galactosidase chart Date: 7 May 1995 23:11:16 GMT Organization: PANIX Public Access Internet and Unix, NYC Lines: 102 Message-ID: <3ojk2k$rcb@news.panix.com> NNTP-Posting-Host: 166.84.254.106 Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1b3 (Macintosh; I; 68K) To: gwelz@holonet.net X-URL: news:bionet.genome.chromosomes Readers, In an earlier posting I proposed that it could be valuable to consider the genome as a computer program and analyze it with flow charts of the type used in writing software. Since that time I have received some very helpful email concerning how this might be done. Several readers said that the genome's program must be a highly parallel one and that we must think of flow charts as diagrams representing the processes involved in gene expression. These would not be charts of a program that is written in the gene, so much as they are descriptions of the processes that can be observed. As a sample of the kind of chart I have in mind, below is a flow chart for the expression of the beta-galactosidase gene in E. coli. This is obviously a well known process, though perhaps not previously represented in this kind of programming schematic. *********** Flow Chart of the process of beta-galactosidase gene expresssion in E. coli | |__________________________________________ | | / \ | / \ | / if \ ___________ | /glucose\____yes_| b-gal not | | \present/ |transcribed| | \ / |___________| | (activator shows | small molecule | present) | | | |no | | | | | | | / \ _________________ | / if \ |repressor binds | | /lactose\--yes--|to operator | | \present/ | b-gal not tran-| | \ / |scribed | | \ / |________________| | |no | | | ____|_________________ | |RNA Polymerase | | |transcribes | | |gene, b-gal made | | |_____________________| | | | | |-- glucose | | feedback ____|_______________________________ | loop |b-gal enzyme breaks down lactose | | | into galactose and glucose |__________| |__________________________________| ******** Please suggest other processes that could be expressed in this way. I want to extend this method to larger parts of genomes and ultimately entire genomes. A crude picture of the entire genome of some virus or bacteria would be a good start. On the macro-scale it must look something like this: | | ____ ..... ___/\-----------/\___| |...... /\ \/ \/ |__| \/ | | | | | /\-----| . . \/ . . . | . There would be many processes running concurrently with some dashed lines representing connections between them. The two main subroutines would be a developmental subroutine and a "life function" subroutine. The developmental routine would handle all the gene expressions involved in organism development, the life function routine would handle all the gene expressions involved in eating, breathing, excretion, reproduction and so forth. Initially the developmental round would dominate, later the functional routine would. My first article dealing with this topic is scheduled to appear in the July issue of a new computer magazine called "The X Advisor" - I will post an early draft here during the coming weeks. Comments are welcome. Gary Welz Dept. of Mathematics John Jay College City University of New York From owner-chromosomes@net.bio.net Sun May 07 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!gatech!europa.chnt.gtegsc.com!casaba.srv.cs.cmu.edu!das-news2.harvard.edu!fas-news.harvard.edu!mito!robison From: robison@mito.harvard.edu (Keith Robison) Newsgroups: bionet.genome.chromosomes Subject: Re: Genome as Program II: b-galactosidase chart Date: 8 May 1995 13:26:12 GMT Organization: Harvard University, Cambridge, Massachusetts Lines: 22 Message-ID: <3ol65k$slh@decaxp.harvard.edu> References: <3ojk2k$rcb@news.panix.com> NNTP-Posting-Host: mito.harvard.edu X-Newsreader: TIN [version 1.2 PL2] Your flowchart for lacZ expression already presents the danger of being interpreted in a linear fashion. The "decisions" made by lacI (repressor) and CRP are made in parallel. You probably have not made the mistake, but your diagram would suggest that CRP acts first and lacI second. I think you'll find such diagrams will suffer from such problems increasingly as you try to model a significantly complex system. Flowcharts are inherently linear beasts, ill-suited for parallel processes, especially biological ones with many non-linearly combined inputs. Keith Robison Harvard University Department of Cellular and Developmental Biology Department of Genetics / HHMI robison@mito.harvard.edu From owner-chromosomes@net.bio.net Sun May 07 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!panix!usenet From: Gary Welz Newsgroups: bionet.genome.chromosomes Subject: Re: Genome Program II Date: 8 May 1995 18:01:49 GMT Organization: PANIX Public Access Internet and Unix, NYC Lines: 75 Message-ID: <3olmad$bce@news.panix.com> NNTP-Posting-Host: 166.84.254.106 Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1b3 (Macintosh; I; 68K) To: robison@mito.harvard.edu,gwelz@panix.com X-URL: news:bionet.genome.chromosomes Keith, Thanks for your comments robison@mito.harvard.edu (Keith Robison) wrote: >Your flowchart for lacZ expression already presents the danger of >being interpreted in a linear fashion. The "decisions" made by >lacI (repressor) and CRP are made in parallel. You probably have >not made the mistake, but your diagram would suggest that CRP acts >first and lacI second. Yes, this is probably a necessary correction. But discussing these things is just part of the process of refining the model. It wasn't obvious to me that these "decisions" are made in parallel - at least not parallel until the activator initially signaled that there was no glucose present. (BTW, I know the yes/no were initially mistakenly placed on the wrong branches of output on the "lactose present" diamond. I asked the moderator to post a comment about this, because, for some reason, I can't see my original posting - only Robison's response. Maybe it's my news server.) > >I think you'll find such diagrams will suffer from such problems >increasingly as you try to model a significantly complex system. >Flowcharts are inherently linear beasts, ill-suited for parallel >processes, especially biological ones with many non-linearly combined >inputs. > Yes, these problems will definitely increase. The representation is meant to be suggestive of the large scale structure. Eventually any flow chart will look like a tangled mess, but that still doesn't discourage me from making more charts. At least not until I or someone else comes up with a better representation of these processes. Though this type of representation is crude and inherently flawed, I haven't seen significantly better ones of gene expression processes in textbooks or journal articles. Maybe someone can give me a good reference? I know there are diagrams representing interactions, but they usually relate to the physical relationships of the genes, RNA and ribosomes rather than abstract diagrams of processes. I'm trying to get away from the topography - i.e. the physical layout of things - and instead make sense of the relationships between processes. Diagrams I've seen of interactions haven't really indicated the overall flow of events, that's also part of what I'm trying to get at. What might be some of the intitial processes on a chart for a whole organism be? Final processes? What's the relationship between different developmental subroutines? Those are some of the questions that I think would benefit from a large scale analysis. I want to step back and try to see the whole elephant - even if my vision is blurred. You mentioned problems with >non-linearly combined inputs. Yeah, that may be tricky, but think about the fuzzy logic chip that controls the processes taking place in expensive Japanese cars. > > >Keith Robison >Harvard University >Department of Cellular and Developmental Biology >Department of Genetics / HHMI > >robison@mito.harvard.edu > Gary Welz From owner-chromosomes@net.bio.net Tue May 09 23:00:00 1995 Path: biosci!rutgers!uwm.edu!spool.mu.edu!usenet.eel.ufl.edu!europa.chnt.gtegsc.com!news.sprintlink.net!EU.net!news2.EUnet.fr!ceph.cephb.fr!szobo From: szobo@ceph.cephb.fr (Geraldine Szoboszlai) Newsgroups: bionet.molbio.embldatabank,bionet.molbio.genbank,bionet.molbio.gdb,bionet.genome.chromosomes Subject: Oncogenes database Date: 10 May 1995 10:47:37 +0200 Organization: Fondation J. Dausset - CEPH Lines: 6 Distribution: world Message-ID: <3opuj9$4aa@ceph.cephb.fr> NNTP-Posting-Host: ceph.cephb.fr Keywords: oncogene Xref: biosci bionet.molbio.embldatabank:497 bionet.molbio.genbank:2020 bionet.molbio.gdb:325 bionet.genome.chromosomes:579 I m looking for a database of cytogenetic localisation of known oncogenes and antioncogenes. Can anybody help me ? Please reply by mail, thank you. From owner-chromosomes@net.bio.net Tue May 09 23:00:00 1995 Path: biosci!biosci!not-for-mail From: ert@karlo.wi.mit.edu (Ert Dredge) Newsgroups: bionet.genome.chromosomes,bionet.announce Subject: Release Ten of the Whitehead-MIT genetic map of the mouse Date: 10 May 1995 16:54:38 -0700 Organization: Massachvsetts Institvte of Technology Lines: 50 Sender: biohelp@net.bio.net Approved: bionews-moderator@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Keywords: Whitehead,MIT,mouse,map,genetic map,mouse genome Xref: biosci bionet.genome.chromosomes:580 bionet.announce:2070 ANNOUNCING THE TENTH RELEASE OF THE WHITEHEAD INSTITUTE/MIT GENOME CENTER GENETIC MAP OF THE MOUSE Release Ten of the Whitehead Institute/MIT Genome Center Genetic Map of the Mouse is now available. This map consists of randomly-chosen simple sequence length polymorphisms (microsatellites) that can be analyzed using the polymerase chain reaction, as described in Dietrich, W., et. al., Genetics 131:423-447 (1992). Currently the released map contains 6183 markers. The markers fall into 20 linkage groups spanning approximately 1400 cM with an average spacing of less than 0.25 cM. This data can be obtained in three different ways: 1. Via a World Wide Web browser. Point your WWW client (e.g., NCSA Mosaic, Netscape) at http://www-genome.wi.mit.edu/ This is the preferred method. 2. Via internet e-mail using a database e-mail server. Using this service you can obtain locus and assay names of mapped SSLPs, the forward and reverse primer sequences, the genotypes of the loci on the mapping cross, the sizes of the PCR products on selected standard inbred strains, and other useful information. The database can be queried for markers meeting a number of different criteria. For example, you can ask for markers by name, by chromosome, or by position on the map. You can even request a list of markers that are polymorphic between two mouse strains. To obtain copies of the most current e-mail query forms, send a message to "genome_database@genome.wi.mit.edu" with either a subject line or body text of "help". You will receive instructions and a query form by return mail. Just fill out the form, send it to "genome_database@genome.wi.mit.edu", and the answer to your query will be mailed back automatically. 3. Via anonymous ftp to genome.wi.mit.edu. Log in as "anonymous" and use your e-mail address as password. The release can be found in the directory /distribution/mouse_sslp_release/apr95/. The file "README" describes the file format and gives other information about the map. Please address questions and comments to me at the address below. Ert Dredge -- --------------------------------------------------------------------------- Ert Dredge Sanj and I play Canadian tunes! 617-252-1922, FAX: 617-252-1902 Mondays 8:30-10:30pm on 88.1 FM http://www.mit.edu:8001/people/ert/home.html PGP Key on WWW page --------------------------------------------------------------------------- From owner-chromosomes@net.bio.net Wed May 10 23:00:00 1995 Path: biosci!rutgers!uwm.edu!fnnews.fnal.gov!lakesis.fapesp.br!bee.uspnet.usp.br!carpa.ciagri.usp.br!mamondin From: mamondin@ciagri.usp.br (Mateus Mondin) Newsgroups: bionet.genome.chromosomes Subject: Citogenetic of Maize (Zeas mays) Date: 11 May 1995 01:39:39 GMT Organization: Universidade de Sao Paulo / Brasil Lines: 21 Message-ID: <3orpsr$5v6@bee.uspnet.usp.br> NNTP-Posting-Host: carpa.ciagri.usp.br X-Newsreader: TIN [version 1.2 PL2] Hello... I need informations about citogenetic stability of culture tissue (maize), for my job Please who has information, write to me in e-mail below. Thanks Mondin, Mateus --------------------------------------------------- Mateus Mondin Universidade de Sao Paulo ESALQ Departamento de Genetica Setor de Citologia mamondin@carpa.ciagri.usp.br ------------------------------------------------------ From owner-chromosomes@net.bio.net Sun May 14 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!spool.mu.edu!uwm.edu!fnnews.fnal.gov!lakesis.fapesp.br!bee08.uspnet.usp.br!bee.uspnet.usp.br!carpa.ciagri.usp.br!anoslima From: anoslima@ciagri.usp.br (Andre O.S. Lima) Newsgroups: bionet.genome.chromosomes Subject: XX Reuniao Anual de Genetica de Microrganismos Date: 15 May 1995 14:54:43 GMT Organization: Universidade de Sao Paulo / Brasil Lines: 34 Message-ID: <3p7pvj$7vk@bee.uspnet.usp.br> NNTP-Posting-Host: carpa.ciagri.usp.br X-Newsreader: TIN [version 1.2 PL2] Piracicaba, 15 de maio de 1995 CONVITE Convidamos a todos os interessados em genetica de microrganismos e areas a fins a participar da XX Reuniao Anual de Genetica de Microrganismos (XX RAGM), que sera realizado de 4 a 7 de julho de 1995 na Escola Superior de Agricultura "Luiz de Queiroz" (ESALQ / USP) em Piracicaba, estado de Sao Paulo/Brasil. Como nas reunioes anteriores, esta tambem sera precedida de cursos pre reuniao (dias 3 e 4 de julho), possibilitando uma atualizacao de conhecimentos de professores, pesquisadores, tecnicos e alunos de graduacao e pos-graduacao na area. Como nos anos anteriores o programa foi cuidadosamente elaborado incluindo, simposios, mesas-redondas, conferencias e outras atividades, alem das apresentacoes das comunicacoes cientificas nas sessoes de posters. Esperamos sua ativa participacao. Comissao Organizadora da XX RAGM 1. Local da Reuniao: Pavilhao de Engenharia da Escola Superior de Agricultura "Luiz de Queiroz" ESALQ/USP. 2. Cursos Pre-Reuniao: Departamento de Genetica (ESALQ/USP) 3. Envios de Resumos: ate 31 de maio de 1995 4. Maiores informacoes: Comissao Organizadora do XX RAGM a/c Joao Lucio de Azevedo Departamento de Genetica (ESALQ/USP) Caixa Postal 83 13.400-970 - Piracicaba/SP Brasil Telefone: (0194) 294100 ramal 4251 FAX: (0194) 336706 E-mail: jlazevedo@pintado.ciagri.usp.br anoslima@carpa.ciagri.usp.br From owner-chromosomes@net.bio.net Mon May 15 23:00:00 1995 Newsgroups: bionet.genome.chromosomes Path: biosci!rutgers!gatech!news.sprintlink.net!pipex!oleane!jussieu.fr!univ-lyon1.fr!swidir.switch.ch!news.unige.ch!usenet From: sanchez@sc2a.unige.ch (Alicia Sanchez-Mazas) Subject: SEARCH FOR CARYOTYPES Message-ID: <1995May16.155826.22467@news.unige.ch> Sender: usenet@news.unige.ch Organization: Dpt. Anthropology, U of Geneva X-Newsreader: WinVN 0.92.6+ Date: Tue, 16 May 1995 15:58:26 GMT Lines: 30 MAYBE YOU CAN YOU HELP ME: I am trying to gather genetic information and caryotypes pictures for a number of animal species, to present them in an important exhibition on biodiversity which will be shown in Geneva in october 95 (Natural History Museum). It is not easy to get this information, especially caryotypes ! So I am asking whether some lab could provide me this kind of data: - a list with the number of chromosomes, DNA content (pg and/or kb), (+ sex chromosomes if known) for different animal (and plant) species. - the pictures and/or photographs of the CARYOTYPES for the same species. (- if photographs of the corresponding animals are available, this would be very useful also) Of course, the first kind of information is available for many groups in many books. But it is lacking for others. Depending on what you are concerned with, we can discuss through E-mail. The second kind of documents (caryotypes) are most often difficult to get... The name of the lab or person who provides the documents will of course be mentionned in this exhibition. I hope that someone can help me, at least to give me some references, or persons to contact. THANK YOU ! NB: IF YOU WANT TO GET MORE INFORMATION about the last exhibition we organized, this is the WEB address: http://acasun1.unige.ch/LGB/LGB-expo.html From owner-chromosomes@net.bio.net Mon May 15 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!news.sprintlink.net!uunet!news.u.washington.edu!homer19.u.washington.edu!mylerpj From: Peter Myler Newsgroups: bionet.genome.chromosomes Subject: Oligonucleotide synthesizer Date: Tue, 16 May 1995 09:26:36 -0700 Organization: University of Washington Lines: 23 Message-ID: NNTP-Posting-Host: nntp4.u.washington.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII Hi folks: I hope that the following does not seem like a commercial message. We are a non-profit Biomedical Research Institution and we have an oligo sysnthesizer which we no longer use and would like to sell. The description follows. ABI Synthesizer, PCP-Mate EP, Model #391. Menu driven software. Purchased in 1990. Machine used for 2 months and then put into storage, in "like new" condition. Machine synthesizes oligonucleotides one base at a time, excess reagents removed by filtration, high coupling efficiencies. $2,200. If interested please contact: =============================================================================== Peter J. Myler phone: (206) 284-8846x332 Seattle Biomedical Research Institute FAX: (206) 284-0313 4 Nickerson Street e-mail: MYLERPJ@U.WASHINGTON.EDU Seattle, WA 98109-1651 =============================================================================== From owner-chromosomes@net.bio.net Tue May 16 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!gatech!swrinde!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: wow24@aol.com (Wow24) Newsgroups: bionet.genome.chromosomes Subject: Mosaicism Date: 16 May 1995 22:45:58 -0400 Organization: America Online, Inc. (1-800-827-6364) Lines: 3 Sender: root@newsbf02.news.aol.com Message-ID: <3pbo16$dbe@newsbf02.news.aol.com> Reply-To: wow24@aol.com (Wow24) NNTP-Posting-Host: newsbf02.mail.aol.com Could anyone send me any kind of information regarding this genetic disorder? I can only find very vague definitions of it, but no manifestations or symptoms to look for. Please help!!!! Please! From owner-chromosomes@net.bio.net Tue May 16 23:00:00 1995 Path: biosci!ATMOS.ALBANY.EDU!jeff From: jeff@ATMOS.ALBANY.EDU (Jeff M. Freedman) Newsgroups: bionet.genome.chromosomes Subject: De novo marker chromosomes Date: 17 May 1995 14:57:52 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 11 Sender: daemon@net.bio.net Distribution: world Message-ID: <9505172157.AA04031@aspen.albany.edu> NNTP-Posting-Host: net.bio.net I've recently had an unfortunate personal experience with a prenatal marker (mosaic) chromosome diagnosis. Specifically, a "non- satellited" marker chromosome. The latest information I've been able to find regarding this diagnosis and its clinical significance is an article by Dorothy Warburton in Am. J. Hum Genet. (1991). If anyone has any more recent information regarding this condition I'd greatly appreciate hearing from you. Thanks. jeff@atmos.albany.edu From owner-chromosomes@net.bio.net Wed May 17 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!swrinde!sgiblab!enews.sgi.com!decwrl!tribune.usask.ca!canopus.cc.umanitoba.ca!newsflash.concordia.ca!news.mcgill.ca!test-air From: popa0206@po-box.mcgill.ca (Grumbler) Newsgroups: bionet.genome.chromosomes Subject: Re: Mosaicism Date: 17 May 1995 23:45:21 GMT Organization: fringe Lines: 14 Message-ID: <3pdu3f$9tg_001@news.mcgill.ca> References: <3pbo16$dbe@newsbf02.news.aol.com> NNTP-Posting-Host: d-08.das.mcgill.ca X-Newsreader: News Xpress Version 1.0 Beta #3 In article <3pbo16$dbe@newsbf02.news.aol.com>, wow24@aol.com (Wow24) wrote: >Could anyone send me any kind of information regarding this genetic >disorder? I can only find very vague definitions of it, but no >manifestations or symptoms to look for. Please help!!!! Please! The best and easiest example is the Calico cat... the coat color is coded for by genes on the X chromosome. Due to random inactivation of one X chromosome or the other you get a cat with patches of different colored fur corresponding to which (colored) parent the active X chromosome in those tissues is derived from. G. From owner-chromosomes@net.bio.net Wed May 17 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!mcrcim.mcgill.edu!news.mcgill.ca!usenet From: Graham Dellaire Newsgroups: bionet.genome.chromosomes Subject: Call for a recombination news group!?!? Date: 16 May 1995 02:36:02 GMT Organization: McGill University (Exp. Medicine) Lines: 21 Message-ID: <3p932i$735@sifon.cc.mcgill.ca> NNTP-Posting-Host: d-11.das.mcgill.ca X-Newsreader: AIR News 3.X (SPRY, Inc.) I think there should be a recombination news group.... perhaps bionet.genome.recombination or bionet.genes.recombination If anyone agrees please post here !!! _______________________________________________________________________ Graham Dellaire Snail Mail: Red Cross, Research McGill Univeristy Montreal Blood Services Faculty of Medicine 3131 Sherbrooke St. East Div. of Experimental Medicine Montreal, QC, Canada E-mail: popa0206@po-box.mcgill.ca H1W 1B2 B2XE@musicb.mcgill.ca Fax: (514) 525 0881 Voice: (514) 527 1501 ext 175 _______________________________________________________________________ From owner-chromosomes@net.bio.net Wed May 17 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!gatech!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: voyager777@aol.com (Voyager777) Newsgroups: bionet.genome.chromosomes Subject: 1,5 Balanced translocations Date: 17 May 1995 22:32:41 -0400 Organization: America Online, Inc. (1-800-827-6364) Lines: 10 Sender: root@newsbf02.news.aol.com Message-ID: <3pebk9$k4@newsbf02.news.aol.com> Reply-To: voyager777@aol.com (Voyager777) NNTP-Posting-Host: newsbf02.mail.aol.com I am interested in any information regarding the outcome of a fetus with a 1,5 balanced translocation. One parent also exhibits this karyotype and is phenotypically normal. Specifically is there any reliable data to support the supposition that the risk to the fetus is no higher than the so called "background risk" of a "normal" karyotype. Is there any testing available to evaluate for a submicroscopic deletion as a result of this balanced translocation? From owner-chromosomes@net.bio.net Thu May 18 23:00:00 1995 Path: biosci!rutgers!concert!ussun2n.glaxo.com!usenet From: Paul J Furdon Newsgroups: bionet.genome.chromosomes Subject: Re: Mosaicism Date: 19 May 1995 14:26:22 GMT Organization: Glaxo Research Institute Lines: 15 Message-ID: <3pi9qe$8qt@ussun2n.glaxo.com> References: <3pbo16$dbe@newsbf02.news.aol.com> NNTP-Posting-Host: us6f12.glaxo.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; PPC) X-URL: news:3pbo16$dbe@newsbf02.news.aol.com wow24@aol.com (Wow24) wrote: >Could anyone send me any kind of information regarding this genetic >disorder? I can only find very vague definitions of it, but no >manifestations or symptoms to look for. Please help!!!! Please! This might get you started. In OMIM go to: http://gdbwww.gdb.org/omim/omimx?158250 There are links to other areas and some clinical info. Paul Furdon Glaxo Wellcome Inc. From owner-chromosomes@net.bio.net Thu May 18 23:00:00 1995 Newsgroups: bionet.genome.chromosomes Path: biosci!bloom-beacon.mit.edu!usc!howland.reston.ans.net!news.sprintlink.net!demon!uknet!bcc.ac.uk!dac159!dcurtis From: dcurtis@hgmp.mrc.ac.uk (David Curtis) Subject: Re: Call for a recombination news group!?!? Sender: news@ucl.ac.uk (Usenet News System) Message-ID: Date: Fri, 19 May 1995 09:38:36 GMT References: <3p932i$735@sifon.cc.mcgill.ca> Organization: Institute of Psychiatry X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] Lines: 18 In article <3p932i$735@sifon.cc.mcgill.ca> Graham Dellaire writes: >I think there should be a recombination news group.... perhaps bionet.genome.recombination >or bionet.genes.recombination >If anyone agrees please post here !!! I _don't_ agree. There's enough genetics newsgroups already, and the ones I get don't have much traffic individually. There's always bionet.molbio.gene-linkage for linkage/recombination issues, and I can't see the point of another similar group. Just 2p from me. Dave Curtis (dcurtis@hgmp.mrc.ac.uk) http://www.iop.bpmf.ac.uk/home/depts/psychmed/general/dcurtis/dcurtis.htm From owner-chromosomes@net.bio.net Fri May 19 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!spool.mu.edu!uwm.edu!rutgers!utcsri!newsflash.concordia.ca!news.mcgill.ca!usenet From: Graham Dellaire Newsgroups: bionet.genome.chromosomes Subject: Re: Call for a recombination news group!?!? Date: 20 May 1995 14:22:47 GMT Organization: McGill University (Exp. Medicine) Lines: 61 Message-ID: <3pktvn$fel@sifon.cc.mcgill.ca> References: NNTP-Posting-Host: e-04.das.mcgill.ca X-Newsreader: AIR News 3.X (SPRY, Inc.) > dcurtis@hgmp.mrc.ac.uk (David Curtis) writes: > In article <3p932i$735@sifon.cc.mcgill.ca> Graham Dellaire writes: > > >I think there should be a recombination news group.... perhaps bionet.genome.recombination > >or bionet.genes.recombination > > >If anyone agrees please post here !!! > > I _don't_ agree. There's enough genetics newsgroups already, and the ones I > get don't have much traffic individually. There's always > bionet.molbio.gene-linkage for linkage/recombination issues, and I can't see > the point of another similar group. > > Just 2p from me. > > I agree there are too many genetics news groups and they often overlap! This bothers me definately!!! But there is no proper forum for recombination issues....Such as models, talk of site specific systems, comparisons between bacteria and mammalian recombination. Recombination and evolution, speciation, gene therapy, techniques for studying recombination such as in vitro/invivo assays in yeast and bacteria, chromosome stucture and its affect on recombination, affect of transcription/replication on recombination illegitimate vs. homologous. Gene targeting strategies. Effect of supercoiling/ and or other topological changes and recombination. Bent DNA and recombination/ cruciform z-DNA and triple helix formation and recombination. etc... the list goes on besides the gene targeting I have not seen any coverage of thes topics ... If you still aren't convinced post again and I will continue my list : ) Recombination is not just a tool for determining linkage or getting your cell to express protein "X" it is a legitimate topic on its own! Therefore I think there is definately room for a functional News group.... how many post are there in bionet.genome.chrom2 I wonder? huh? Sadly I think your ill-informed post is just a symptom of not having a proper forum for Recombination issues. QED _______________________________________________________________________ Graham Dellaire Snail Mail: Red Cross, Research McGill Univeristy Montreal Blood Services Faculty of Medicine 3131 Sherbrooke St. East Div. of Experimental Medicine Montreal, QC, Canada E-mail: popa0206@po-box.mcgill.ca H1W 1B2 B2XE@musicb.mcgill.ca Fax: (514) 525 0881 Voice: (514) 527 1501 ext 175 _______________________________________________________________________ From owner-chromosomes@net.bio.net Sat May 20 23:00:00 1995 Path: biosci!UQTR.UQuebec.ca!Irene_Gabashvili From: Irene_Gabashvili@UQTR.UQuebec.ca Newsgroups: bionet.genome.chromosomes Subject: (none) Date: 21 May 1995 15:45:29 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Distribution: world Message-ID: <9505212245.AA28659@neptune.UQTR.UQuebec.ca> NNTP-Posting-Host: net.bio.net Re: Recombination New group Proposals for new groups must contain a statement of purpose for the group and the name of a person designated as discussion leader unless the group is in the service category such as METHODS, EMPLOYMENT, etc. Proposals should be sent to biosci-help@net.bio.net. When a proposal is received it will be posted on BIONEWS/bionet.announce. A ten day period for discussion on BIOFORUM/bionet.general will follow and precede the call for votes. After the discussion, the person proposing the newsgroup may modify or withdraw the proposal prior to the call for votes. The modified proposal will then be included in a call for votes on BIONEWS/bionet.announce. The proposal must collect 80 YES votes in 30 days and the number of YES votes must exceed the number of NO votes by at least 40 to pass. BIOSCI management must be informed in advance of any intended efforts to advertise the newsgroup proposal in other forums. ===================================================================== P.S. I think, however, all proposed topics would require the creating of a more common "DNA" news group (like the existing RNA prototype newsgroup. Sincerely, Irene Gabashvili, An Admirer of DNA in all its aspects From owner-chromosomes@net.bio.net Sat May 20 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!swrinde!gatech!rutgers!netnews.upenn.edu!sanger.bcm.tju.edu!tromp From: tromp@sanger.bcm.tju.edu (Gerard Tromp) Newsgroups: bionet.genome.chromosomes Subject: Re: Mosaicism Date: 20 May 1995 23:58:19 GMT Organization: Biochemistry Lines: 58 Distribution: world Message-ID: <3plvmr$6c5@netnews.upenn.edu> References: <3pbo16$dbe@newsbf02.news.aol.com> <3pdu3f$9tg_001@news.mcgill.ca> NNTP-Posting-Host: sanger.bcm.tju.edu Keywords: mosaicism, genetics To: wow24@aol.com (Wow24) Subject: Re: Mosaicism Mosaicism is not a disease per se, it is a state. It indicates that not all the cells of an organism that normally express a particular gene are expressing it. For disease-causing mutations, the founder (first person to have the disease or the parent of such an individual) may be mosaic. This means that the mutation occurred after the fertilized egg split into two or more cells. The mutation will, therefore, not be present in every cell. The body of the organism then has some cells with the mutation and some without, figuratively then like a mosaic, as in the pictures or decorations made of bits of tile or glass, just as the bits of glass or tile are not identical, so the cells of the body do not have an identical genetic complement. The consequences of mosaicism can vary depending on the trait. An example of harmless mosaicism was posted, i.e. the color variation of the calico cat which is a consequence of inactivation of genes on the X chromosome. For genetic disorders, the mosaic individual can often have a less severe disorder and may even have no symptoms at all, depending on when during development the mutation occurred. Some individuals mosaic for a mutation are only detected through multiple affected offspring, and if the mosaicism for the mutation is restricted to their germline cells (the cells generating sperms and eggs), it may be difficult to demonstrate that they are mosaic for the mutation. For males, single sperm PCR can be used. To reiterate, mosaicism in genetics indicates a condition where either all the cells of the body do not have the same genetic complement, or some the expression of the same genetic complement is not the same for all cells of the same tissue. Gerard -- Mailed and posted. ======================================================================= Gerard Tromp, Ph.D. Research Assistant Professor Vox: 215-955-4487 Department of Biochemistry 215-955-4488 and Molecular Biology Fax: 215-955-5393 Thomas Jefferson University 233 South Tenth Street, Room 328 E-mail: tromp@sanger.bcm.tju.edu Philadelphia, PA 19107 U.S.A. -- ======================================================================= Gerard Tromp, Ph.D. Research Assistant Professor Vox: 215-955-4487 Department of Biochemistry 215-955-4488 and Molecular Biology Fax: 215-955-5393 Thomas Jefferson University 233 South Tenth Street, Room 328 E-mail: tromp@sanger.bcm.tju.edu Philadelphia, PA 19107 U.S.A. From owner-chromosomes@net.bio.net Sat May 20 23:00:00 1995 Path: biosci!agate!newsxfer.itd.umich.edu!gatech!newsfeed.pitt.edu!uunet!in1.uu.net!newsflash.concordia.ca!news.mcgill.ca!test-air From: popa0206@po-box.mcgill.ca (G. Dellaire) Newsgroups: bionet.genome.chromosomes Subject: Re: Recombination New group Date: 21 May 1995 17:28:50 GMT Organization: fringe Lines: 29 Message-ID: <3pnphe$8r8_002@news.mcgill.ca> NNTP-Posting-Host: e-07.das.mcgill.ca X-Newsreader: News Xpress Version 1.0 Beta #3 I would like to propose a news group for recombination. Perhaps something like bionet.genetics.recombination, to deal with issues pertaining to the mechanisms and models of recombination. Also to serve as a forum for professionals in the field of recombination to provide help to those researchers who are involved in gene targeting/transgenics and/or gene therapy projects. Some other possible topics of discussion include 1. Transcription and recombination (triple helix formation) 2. Replication and recombination 3. Evolution of genome (line-1 and alu's etc alpha satellite DNA) 4. DNA Topolgy and its affect on recombination (supercoiling) -Z-DNA, cruciform and bent DNA 5. Site directed recombination systems (FLP/CRE invertases etc.) 6. DNA binding proteins and recombination 7. Homologous vs. Nonhomologous recombination 8. DNA repair systems and diseases involving DNA repair and/or -abberant recombination This is just an abbreviated list of topics that do not have a proper forum for discussion. To often Recombination is just seen as a tool and not a legitimate area of research in its own right. According to one "pundit" who posted here there is no need for such a group I think he is mistaken! From owner-chromosomes@net.bio.net Sun May 21 23:00:00 1995 Path: biosci!daresbury!not-for-mail From: Lucien Bachner Newsgroups: bionet.genome.chromosomes Subject: recombination news-group Date: 22 May 1995 18:55:26 +0100 Lines: 14 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <3pqj6e$h3n@mserv1.dl.ac.uk> Original-To: biochrom@dl.ac.uk Just a word to not waste bandwidth : About the subject I agree totally with Dave Curtis No need for such a group. ========================================================== Lucien Bachner Laboratoire de Biochimie Genetique,Hopital Cochin. 123 Bd. Port Royal, 75014 Paris, France. Tel: (33 1) 42-34-12-12 ext 3039 FAX: (33 1) 44-41-15-22 e-mail : bachner@Cassini.genethon.fr ========================================================== From owner-chromosomes@net.bio.net Sun May 21 23:00:00 1995 Newsgroups: bionet.genome.chromosomes Path: biosci!daresbury!is.bbsrc.ac.uk!bcc.ac.uk!dac159!dcurtis From: dcurtis@hgmp.mrc.ac.uk (David Curtis) Subject: Re: Call for a recombination news group!?!? Sender: news@ucl.ac.uk (Usenet News System) Message-ID: Date: Mon, 22 May 1995 09:42:46 GMT References: <3pktvn$fel@sifon.cc.mcgill.ca> Organization: Institute of Psychiatry X-Newsreader: Trumpet for Windows [Version 1.0 Rev A] Lines: 46 In article <3pktvn$fel@sifon.cc.mcgill.ca> Graham Dellaire writes: >If you still aren't convinced post again and I will continue my list : ) I'm still not convinced. But please don't trouble continuing your list. Why don't you just keep posting on all these topics in this newsgroup, which sees very little traffic. If the vast number of postings on recombination then becomes overwhelming and bothersome for other readers of bionet.genome.chromosomes I would suggest that _then_ would be a good time to consider starting up a new group, not now. >Recombination is not just a tool for determining linkage or getting your cell >to express protein "X" it is a legitimate topic on its own! Well really! >Therefore I think there is definately room for a functional News group.... >how many post are there in bionet.genome.chrom2 I wonder? huh? huh? (Sorry, are you making some point here? It's gone way over my head. The lesson I would learn is that starting up new groups on more limited subjects is a way to generate large numbers of groups each with very little traffic.) >Sadly I think your ill-informed post is just a symptom of not having a proper forum >for Recombination issues. Well silly me. >QED QED? Thus _what_ was demonstrated? OK, there's lots of interesting things to talk about concerning Recombination. (I now realise we have to capitalise it to show due respect, another fact I was unaware of previously, but that's the beauty of these news groups, a constant exposure to previously unknown facts.) IMHO you need to demonstrate that there is an interest in discussing the topic (maybe) _and_ that discussion can't be handled by a pre-existing group. You asked for opinions on whether the new group would be a good idea. I gave my opinion. I had no idea that you felt so passionately about the subject that I risked such abusive responses from you, if so I simply wouldn't have bothered replying. A public apology would be in order, but I don't expect one. Dave Curtis (dcurtis@hgmp.mrc.ac.uk) http://www.iop.bpmf.ac.uk/home/depts/psychmed/general/dcurtis/dcurtis.htm From owner-chromosomes@net.bio.net Mon May 22 23:00:00 1995 Path: biosci!agate!sunsite.doc.ic.ac.uk!hgmp.mrc.ac.uk!gwilliam From: gwilliam@hgmp.mrc.ac.uk (Gary Williams) Newsgroups: bionet.genome.chromosomes Subject: Recombination question Date: 23 May 1995 08:41:32 GMT Organization: UK HGMP Resource Centre Lines: 21 Message-ID: <3ps73s$hq3@mercury.hgmp.mrc.ac.uk> NNTP-Posting-Host: gallium.hgmp.mrc.ac.uk I have some questions about recombination. They are probably well known to experts in the field, but I shall expose my ignorance. Are there regions in the genome which have large numbers of recombinations, aided by recognition of sites by proteins? Are the signals for such sites known? Is recombination within exons less frequent than outside them? (This may be difficult to measure, assuming there may be lethal disruption of the cell's machinery when this occurs). Gary Williams -- GARY WILLIAMS, Internet: G.Williams@HGMP.MRC.AC.UK Tel: 01223 494522 Computing Services, HGMP Resource Centre, Hinxton Hall, Hinxton, Cambridge, CB10 1RQ UK MRC HGMP Resource Centre From owner-chromosomes@net.bio.net Mon May 22 23:00:00 1995 Path: biosci!ACS.TAMU.EDU!J0V8959 From: J0V8959@ACS.TAMU.EDU Newsgroups: bionet.genome.chromosomes Subject: recombination newsgroup Date: 22 May 1995 18:22:21 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 3 Sender: daemon@net.bio.net Distribution: world Message-ID: <950522202122.214009cb@ACS.TAMU.EDU> NNTP-Posting-Host: net.bio.net I agree with Dave Curtis that there is no need for a seperate newsgroup. This newsgroup certainly could accommodate discussions about recombination. J.P. van Buijtenen From owner-chromosomes@net.bio.net Mon May 22 23:00:00 1995 Newsgroups: bionet.genome.chromosomes Path: biosci!rutgers!gatech!news.sprintlink.net!demon!doc.news.pipex.net!pipex!oleane!jussieu.fr!univ-lyon1.fr!swidir.switch.ch!newsfeed.ACO.net!Austria.EU.net!EU.net!ieunet!maths.tcd.ie!news.tcd.ie!acer.gen.tcd.ie!dbarton From: dbarton@acer.gen.tcd.ie (Dr David E Barton) Subject: Re: Call for a recombination news group!?!? Message-ID: Sender: usenet@news.tcd.ie (TCD News System ) Organization: Irish National Centre for Bioinformatics References: <3pktvn$fel@sifon.cc.mcgill.ca> Date: Tue, 23 May 1995 15:39:42 GMT Lines: 10 'Go Dave!! I couldn't agree more. \|/ ____ \|/ | David Barton @~/ .. \~@ | National Centre for Medical Genetics /_( \__/ )_\ | Our Lady's Hospital for Sick Children \__U_/ | Crumlin, Dublin 12, Ireland. From owner-chromosomes@net.bio.net Mon May 22 23:00:00 1995 Path: biosci!MORGAN.HARVARD.EDU!flybase From: flybase@MORGAN.HARVARD.EDU (FlyBase Project Members) Newsgroups: bionet.genome.chromosomes Subject: Encyclopaedia of Drosophila CD-ROM Date: 23 May 1995 08:39:34 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 121 Sender: daemon@net.bio.net Distribution: world Message-ID: <9505231543.AA13305@morgan.harvard.edu> NNTP-Posting-Host: net.bio.net The Encyclopaedia of Drosophila CD-ROM Macintosh Compatible only Release 1.0 The Berkeley Drosophila Genome Project (BDGP) and FlyBase announce Release 1.0 of the Macintosh CD-ROM version of the Encyclopaedia of Drosophila (EofD). This is the same version of the EofD CD-ROM that was distributed to registrants at the April 1995 Drosophila Research Conference in Atlanta. The EofD is a graphical interface based on the ACeDB software first developed for the C. elegans database and now in use as a powerful browsing and querying tool for many genome databases. Multiple data sets are displayed on chromosomal maps in which text descriptions of data items are displayed on command by mouse-driven "pointing and clicking". Release 1.0 combines data from the BDGP and from FlyBase in an integrated view. In Release 1.0, all BDGP data (except DNA sequences) and much (but not all) FlyBase data are contained. In contrast, the FlyBase World Wide Web home page (URL = http://morgan.harvard.edu/) contains more FlyBase data but only a subset of BDGP data. Our long term goal is that both the EofD and the FlyBase home page will provide different views of the same comprehensive data set. However, we are probably about a year away from achieving this goal. Before purchasing the EofD, you should make sure you have access to a Macintosh computer with the following attributes: The EofD CD-ROM can only be run on higher end Macintosh computers, those equipped with 68040 or PowerPC processors and a CD-ROM drive. The application runs in native mode on the Power Macintosh and we recommend the Power Macintosh for optimal performance. The EofD requires System 7.1 or higher. System 7.5 is required to use the EofD Guide help facilities. In addition, QuickTime is required to play movies supplied on the CD-ROM. The EofD requires a minimum of 16 Megabytes (MB) of RAM. We recommend turning on Virtual Memory and setting it to at least 32 MB. ------------------------------------------------------------------------ The costs of the EofD, including shipping and handling, are, per CD-ROM and user manual: $10 for U.S. purchases and shipment to a U.S. address $15 for international purchases and shipment Order forms must be accompanied by checks or money orders in US dollars made out to "EofD". Only prepaid orders will be accepted. *** Please do *not* send in your order by email! *** Inquiries concerning EofD purchases may be made by telephone to Ms. Palmer at (617) 495-2906 or fax at (617) 495-9300 or by email to eofd-sales@morgan.harvard.edu. Questions concerning the structure or operation of the EofD should be e-mailed to eofd@fly2.berkeley.edu. ------------------------------------------------------------------------- ------------------------------------------------------------------------- PRINT OUT AND MAIL THE FOLLOWING FORM TO EofD c/o Dawn Palmer AT THE ADDRESS BELOW. ORDERS MUST BE PREPAID. THE ORDER MUST BE ACCOMPANIED BY PAYMENT IN FULL IN A CHECK IN U.S. CURRENCY. ANY OTHER FORM OF PAYMENT WILL BE RETURNED AS INCOMPLETE. ------------------------------------------------------------------------- ------------------------------------------------------------------------- *************************** EofD Release 1.0 ORDER FORM *************************** Name __________________________________________________ Address _______________________________________________ _______________________________________________ _______________________________________________ _______________________________________________ Telephone ________________________________________ Fax ______________________________________________ Email ____________________________________________ ---------------------------------------------------------------- ALL ORDERS MUST BE ACCOMPANIED BY FULL PAYMENT IN U.S. CURRENCY DRAWN ON A U.S. BANK MAKE CHECKS PAYABLE TO "EofD" Orders accompanied by insufficient funds will be returned. No purchase orders, credit card or standing orders can be accepted. _______ copies of EofD at $10 per copy for shipment within the USA $__________ _______ copies of EofD at $15 per copy for international shipment $__________ Orders must be mailed to: EofD c/o Dawn Palmer The Biological Laboratories Harvard University 16 Divinity Avenue Cambridge, MA 02138 USA *** Please do *not* send in your order by email! *** From owner-chromosomes@net.bio.net Mon May 22 23:00:00 1995 Path: biosci!bcm!cs.utexas.edu!howland.reston.ans.net!swrinde!news.uh.edu!usenet From: Dan Wells Newsgroups: bionet.genome.chromosomes Subject: Gene within a gene Date: 23 May 1995 16:51:16 GMT Organization: University of Houston Lines: 3 Message-ID: <3pt3q4$7qf@masala.cc.uh.edu> NNTP-Posting-Host: mac-940.sr2-building.uh.edu I remember reading of a mammalian gene that was contained within the intron of another gene, but I cant remember which genes were involved. Can some one help me out. From owner-chromosomes@net.bio.net Tue May 23 23:00:00 1995 Path: biosci!rutgers!oitnews.harvard.edu!das-news2.harvard.edu!fas-news.harvard.edu!nucleus!robison From: robison@nucleus.harvard.edu (Keith Robison) Newsgroups: bionet.genome.chromosomes Subject: Re: Gene within a gene Date: 24 May 1995 02:46:10 GMT Organization: Harvard University, Cambridge, Massachusetts Lines: 31 Message-ID: <3pu6li$8ka@decaxp.harvard.edu> References: <3pt3q4$7qf@masala.cc.uh.edu> NNTP-Posting-Host: nucleus.harvard.edu X-Newsreader: TIN [version 1.2 PL2] Dan Wells (DWELLS@UH.EDU) wrote: : I remember reading of a mammalian gene that was contained : within the intron of another gene, but I cant remember which : genes were involved. Can some one help me out. There are several of examples of these -- but I can't claim to list them all. The neurofibromatosis type I gene contains at least one other gene in its introns, and I think it's more like 2 or 3. The DNA sequence for this gene is a member of the still-exclusive 100Kb Club, whose membership list is at http://golgi.harvard.edu/100kb/ You'll find a link there to the Entrez data for this sequence, which will in turn let you get to the citations. My guess is that many large (>50Kb) introns will contain additional transcription units. Enjoy! Keith Robison Harvard University Department of Cellular and Developmental Biology Department of Genetics / HHMI robison@mito.harvard.edu From owner-chromosomes@net.bio.net Tue