From owner-chromosomes@net.bio.net Sun Sep 03 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!newsfeed.internetmci.com!tank.news.pipex.net!pipex!sunsite.doc.ic.ac.uk!yama.mcc.ac.uk!usenet From: Ali Hajeer Newsgroups: bionet.genome.chromosomes Subject: Prolactin Polymorphisms Date: 4 Sep 1995 14:32:09 GMT Organization: Sirius Cybernetics Corporation Lines: 10 Message-ID: <42f2l9$kqd@yama.mcc.ac.uk> NNTP-Posting-Host: pc422.ser.man.ac.uk Does anyone know of polymorphisms in the prolactin gene or any microsatellite close by (PCR based polymorphisms). Thank you Ali Hajeer ARC unit University of Manchester ali@fs1.er.man.ac.uk From owner-chromosomes@net.bio.net Mon Sep 04 23:00:00 1995 Path: biosci!agate!msunews!harbinger.cc.monash.edu.au!yarrina.connect.com.au!labtam!news.mel.aone.net.au!inferno.mpx.com.au!news.unimelb.EDU.AU!news From: Denton Newsgroups: bionet.genome.chromosomes Subject: Cytogenticist Wanted Date: 1 Sep 1995 02:22:34 GMT Organization: The University of Melbourne Lines: 21 Message-ID: <425qpa$10tp@news.unimelb.EDU.AU> NNTP-Posting-Host: ariel.ucs.unimelb.edu.au Mime-Version: 1.0 Content-Type: text/plain Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Windows; I; 16bit) POSITION VACANT CYTOGENETICS There is a position currently available for a an English speaking cytogeneticist with some experience at: Prophase Pathology, Melbourne Australia. For details contact: Ed Krumins 03 9416 2418 after 11th September 1995. From owner-chromosomes@net.bio.net Tue Sep 05 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!tank.news.pipex.net!pipex!wave.news.pipex.net!pipex!dish.news.pipex.net!pipex!handbag.tecc.co.uk!usenet From: chris.s@bbcnc.org.uk (Christopher Swarray) Newsgroups: bionet.genome.chromosomes Subject: Chromosomes ? Date: 6 Sep 1995 17:52:49 GMT Organization: Swarray Enterprises Ltd Lines: 10 Message-ID: <42kn5h$ela@auntie.bbcnc.org.uk> NNTP-Posting-Host: ad062.du.pipex.com X-Newsreader: WinVN 0.92.6+ I need to know how many chromosomes each there are in 5 different animals e.g. 46 means your human and 28 i think, means your a chicken :-) I need to find out by Monday 14th if possible. Thanks in Advance Chris:-) "Don't let your fear stand in the way of your dreams" From owner-chromosomes@net.bio.net Wed Sep 06 23:00:00 1995 Path: biosci!daresbury!nntp-trd.UNINETT.no!Norway.EU.net!EU.net!howland.reston.ans.net!swrinde!tank.news.pipex.net!pipex!in1.uu.net!news.u.washington.edu!root From: dadler@u.washington.edu (David A. Adler) Newsgroups: bionet.genome.chromosomes Subject: Re: music & DNA Date: 7 Sep 1995 19:42:46 GMT Organization: University of Washington Lines: 42 Distribution: world Message-ID: <42nhvm$8r3@nntp3.u.washington.edu> References: <42n77d$1d6g@serra.unipi.it> Reply-To: dadler@u.washington.edu NNTP-Posting-Host: larry.pathology.washington.edu In article <42n77d$1d6g@serra.unipi.it> vassallo@cli.di.unipi.it (Fabrizio Vassallo) writes: > Hallo! > Have anyone heard of relations betw. music & DNA? > please post me > > Fabrizio Susumo Ohno has done some work on representing DNA/protein sequences as musical notes - as a start see for example: Author: Ohno-S. Title: A song in praise of peptide palindromes. Source: Leukemia. 1993 Aug. 7 Suppl 2. P S157-9. Journal Title: LEUKEMIA. Abstract: Peptide palindromes are invariably found in all proteins, and long palindromes exceeding 10 residues in length are not rare. They are particularly abundant in DNA-binding proteins such as H1 histone. When a complementary strand of the coding sequence is translatable being free of a chain terminator, a complementary protein encode by it becomes equally abundant in peptide palindromes. The simultaneous musical transformation of both strands of mouse H1 histone variety-1 DNA enable us to appreciate the symmetrical beauty of successive palindromes appearing in both H1 histone and its complementary protein. Hope this helps, David -- David A. Adler Pathology, Box 357470 University of Washington Seattle, WA 98195 (206) 543-0716 (phone) (206) 543-3644 (fax) "Science is nothing but trained and organized common sense" T.H.Huxley From owner-chromosomes@net.bio.net Wed Sep 06 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!tank.news.pipex.net!pipex!lyra.csx.cam.ac.uk!news From: Richard Korn Newsgroups: bionet.genome.chromosomes Subject: Re: Chromosomes ? Date: 7 Sep 1995 10:06:40 GMT Organization: University of Cambridge Lines: 9 Message-ID: <42mg7g$la4@lyra.csx.cam.ac.uk> References: <42kn5h$ela@auntie.bbcnc.org.uk> NNTP-Posting-Host: png-mac9.gen.cam.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; PPC) To: chris.s@bbcnc.org.uk X-URL: news:42kn5h$ela@auntie.bbcnc.org.uk There are those people who believe that more (or bigger) is better. in that case humans dont do so well with only 46 chromosomes. Chickens have a whole 78 chromosomes to deal with (albeit many of them are tiny). If you need chr. numbers for other species, just decide which ones and we can let you know. Richard From owner-chromosomes@net.bio.net Wed Sep 06 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!tank.news.pipex.net!pipex!oleane!jussieu.fr!univ-lyon1.fr!swidir.switch.ch!serra.unipi.it!giuditta!vassallo From: vassallo@cli.di.unipi.it (Fabrizio Vassallo) Newsgroups: bionet.genome.chromosomes Subject: music & DNA Date: 7 Sep 1995 16:39:09 GMT Organization: Dipartimento di Informatica, Universita' di Pisa Lines: 6 Distribution: world Message-ID: <42n77d$1d6g@serra.unipi.it> NNTP-Posting-Host: giuditta.cli.di.unipi.it X-Newsreader: TIN [version 1.2 PL2] Hallo! Have anyone heard of relations betw. music & DNA? please post me Fabrizio From owner-chromosomes@net.bio.net Thu Sep 07 23:00:00 1995 Path: biosci!agate!boulder!usenet From: Allison Weiss Newsgroups: bionet.genome.chromosomes Subject: (no subject) Date: 7 Sep 1995 17:50:42 GMT Organization: University of Colorado @ Boulder Lines: 11 Message-ID: <42nbdi$7c8@lace.Colorado.EDU> NNTP-Posting-Host: lepc1.colorado.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; PPC) X-URL: news:bionet.genome.chromosomes I am looking for a Human Genomic Library to screen for Myosin Heavy Chain genes. Does anyone have one that you have had success with, or do you perhaps know of any good commercial sources for such a library? Thank you. Allison Weiss Leinwand Lab MCDB (CU) aweiss@stripe.colorado.edu From owner-chromosomes@net.bio.net Thu Sep 07 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!news.sprintlink.net!in2.uu.net!news1.digital.com!nntp-hub2.barrnet.net!nntp-sc.barrnet.net!news.fujitsu.com!amdahl.com!news.svpal.org!hansen From: hansen@svpal.svpal.org (Dave Hansen) Newsgroups: bionet.genome.chromosomes Subject: Re: Chromosomes ? Date: 7 Sep 1995 03:18:24 GMT Organization: Silicon Valley Public Access Link Lines: 31 Message-ID: <42loa0$nen@borg.svpal.org> References: <42kn5h$ela@auntie.bbcnc.org.uk> NNTP-Posting-Host: svpal.svpal.org X-Newsreader: TIN [version 1.2 PL2] In response to the question regarding chromosome count for some animals: You are speaking of chromosome pairs. Humans have 23 pairs or 46. By the same logic, flies (Drosophila melanogaster, for example) have 8, evening bats have 46, the same as humans, rinosceri have 84. Other chromosome pair numbers are: Silk Moth 56 Sea urchin 42 Toad 36 Salamander 38 Chicken 78 Mouse 40 Cow 120 Dave Hansen ( hansen@svpal.org) Christopher Swarray (chris.s@bbcnc.org.uk) wrote: : I need to know how many chromosomes each there are in 5 different animals : e.g. 46 means your human and 28 i think, means your a chicken :-) : I need to find out by Monday 14th if possible. : Thanks in Advance : Chris:-) : "Don't let your fear stand in the way of your dreams" -- From owner-chromosomes@net.bio.net Sat Sep 09 23:00:00 1995 Path: biosci!agate!howland.reston.ans.net!news.sprintlink.net!in2.uu.net!news.compuserve.com!news.production.compuserve.com!news From: Patrick R. Jones <102570.2734@CompuServe.COM> Newsgroups: bionet.genome.arabidopsis,bionet.genome.chromosomes,bionet.immunology,bionet.info-theory,bionet.jobs Subject: Need Help Date: 10 Sep 1995 20:07:01 GMT Organization: Personal Lines: 19 Message-ID: <42vgh5$og2$6@mhafn.production.compuserve.com> Xref: biosci bionet.genome.arabidopsis:3714 bionet.genome.chromosomes:806 bionet.immunology:5400 bionet.info-theory:3600 I am a undergraduate student in biology. Some day I hope to go to graduate school in biochemistry. My grades are good enough but I am afraid that this may not be enough to get in. I am looking for something to set myself apart from the other students. At this point I am at a loss on what to do. I have no real resources to work on projects in the areas that interest me. Does anybody have any ideas? I do have one useful skill. I am a professional computer programmer. I don’t mean someone who has taken a FORTRAN class and is working as a work-study student, but a 10 year application programming veteran in the computing industry. If I could use this skill great if not, I don’t care. I need something to further my career; something good. Please help!!! I know that somebody out there knows of something I could do. Thank you for your time!!! Patrick R. Jones -- <> From owner-chromosomes@net.bio.net Sat Sep 09 23:00:00 1995 Path: biosci!agate!newsxfer.itd.umich.edu!news.eecs.umich.edu!newshost.marcam.com!usc!cs.utexas.edu!howland.reston.ans.net!ix.netcom.com!netnews From: atech@ix.netcom.com (dennis lee ) Newsgroups: bionet.genome.chromosomes Subject: electrical properties of DNA Date: 10 Sep 1995 06:57:05 GMT Organization: Netcom Lines: 7 Message-ID: <42u281$6db@ixnews3.ix.netcom.com> NNTP-Posting-Host: ix-bos6-23.ix.netcom.com X-NETCOM-Date: Sat Sep 09 11:57:05 PM PDT 1995 I believe it is established that the DNA helix possesses electrically conductive properties. Does anyone know of research investigating inductive and/or capacitive measurements of DNA? Please email to me directly. Dennis Lee From owner-chromosomes@net.bio.net Sun Sep 10 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!tank.news.pipex.net!pipex!in2.uu.net!newsflash.concordia.ca!news.mcgill.ca!news From: Graham Dellaire Newsgroups: bionet.genome.chromosomes Subject: Re: puppet children Date: 11 Sep 1995 22:59:29 GMT Organization: McGill University (Exp. Medicine) Lines: 39 Message-ID: <432f0h$7r3@sifon.cc.mcgill.ca> References: <4302gk$h72$1@mhadf.production.compuserve.com> NNTP-Posting-Host: g-07.das.mcgill.ca X-Newsreader: AIR News 3.X (SPRY, Inc.) > Neil Worthington 102705,2475 <102705.2475@CompuServe.COM> writes: > I am trying to find information on "puppet children" which is > refered to as Angelmans syndrome. > >>>> If I am not mistaken Anglemans syndrome (AS) and the reciprocal disease Prader-Willi syndrome(PWS) are disease that share a common characteristic of being imprinted. Imprinting means the espression of the phenotype is "gamete sex dependent". This means that the sex of the parent determines (usually) if the disease occurs or is "manifest". In this case whether it is Prader-Willi or Anglemans syndrome. I believe the gene(s) involved are on chromsome 15 in man the q arm (short) (15q11-q13). The region commonly deleted between the two syndromes is associated with the small nuclear ribonucleoprotein N (SNRPN). Abberant methylation of this region is also associated with the disease and hence further evidence (or support might be better) for imprinting being involved in this disorder. Often the the karotype of individuals with these syndromes reveals duplications and inversions in this arm of chm 15. Usually people with (PWS) lack paternal copy of this region (or this region is abberant in the paternal allele) and the maternal copy is missing or abberant in (AS). _________________________________________________________ Hope this helps G. ______________ Graham Dellaire Snail Mail: Red Cross, Research McGill University Montreal Blood Services Faculty of Medicine 3131 Sherbrooke St. East Div. of Experimental Medicine Montreal, QC, Canada E-mail: popa0206@po-box.mcgill.ca H1W 1B2 B2XE@musicb.mcgill.ca WWW Page: http://www.medcor.mcgill.ca/EXPMED/expmed.html Fax: (514) 525 0881 Voice: (514) 527 1501 ext 175 _______________________________________________________________________ From owner-chromosomes@net.bio.net Sun Sep 10 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!tank.news.pipex.net!pipex!in2.uu.net!newsflash.concordia.ca!news.mcgill.ca!news From: Graham Dellaire Newsgroups: bionet.genome.chromosomes Subject: Re: electrical properties of DNA Date: 11 Sep 1995 22:33:35 GMT Organization: McGill University (Exp. Medicine) Lines: 28 Message-ID: <432dfv$7r3@sifon.cc.mcgill.ca> NNTP-Posting-Host: g-07.das.mcgill.ca X-Newsreader: AIR News 3.X (SPRY, Inc.) Denis, I can't remember the reference off hand but in Science (or was it Nature) there was a paper and news and views article on the fact that DNA can conduct electrons down the center of the double helix! Hope this helps out. If you have access to medline.. or some other search engine just do a key word search for DNA, Electricity and cross reference for Science or Nature articles in 1995. G. _______________________________________________________________________ Graham Dellaire Snail Mail: Red Cross, Research McGill University Montreal Blood Services Faculty of Medicine 3131 Sherbrooke St. East Div. of Experimental Medicine Montreal, QC, Canada E-mail: popa0206@po-box.mcgill.ca H1W 1B2 B2XE@musicb.mcgill.ca WWW Page: http://www.medcor.mcgill.ca/EXPMED/expmed.html Fax: (514) 525 0881 Voice: (514) 527 1501 ext 175 _______________________________________________________________________ From owner-chromosomes@net.bio.net Sun Sep 10 23:00:00 1995 Path: biosci!agate!spool.mu.edu!howland.reston.ans.net!ix.netcom.com!netnews From: hk-miami@ix.netcom.com (HK ) Newsgroups: bionet.genome.arabidopsis,bionet.genome.chromosomes,bionet.immunology,bionet.info-theory,bionet.jobs Subject: Re: Need Help Date: 11 Sep 1995 02:15:14 GMT Organization: Netcom Lines: 34 Message-ID: <43063i$8kt@ixnews4.ix.netcom.com> References: <42vgh5$og2$6@mhafn.production.compuserve.com> NNTP-Posting-Host: ix-mia1-24.ix.netcom.com X-NETCOM-Date: Sun Sep 10 7:15:14 PM PDT 1995 Xref: biosci bionet.genome.arabidopsis:3716 bionet.genome.chromosomes:808 bionet.immunology:5403 bionet.info-theory:3601 In <42vgh5$og2$6@mhafn.production.compuserve.com> Patrick R. Jones <102570.2734@CompuServe.COM> writes: > >I am a undergraduate student in biology. Some day I hope to go to >graduate school in biochemistry. My grades are good enough but I >am afraid that this may not be enough to get in. I am looking for >something to set myself apart from the other students. At this >point I am at a loss on what to do. I have no real resources to >work on projects in the areas that interest me. Does anybody have >any ideas? I do have one useful skill. I am a professional >computer programmer. I don’t mean someone who has taken a FORTRAN >class and is working as a work-study student, but a 10 year >application programming veteran in the computing industry. If I >could use this skill great if not, I don’t care. I need something >to further my career; something good. Please help!!! I know that >somebody out there knows of something I could do. > > Thank you for your time!!! > Patrick R. Jones > >-- ><> What do you mean you don't have the resources to work on a project that interests you? You say that you are an undergraduate student. Go to one of your professors and ask him or her if you could do a research project in his/her lab. Can't think of anything more impressive on an undergrads resume than a publication with his/her name as one of the authors. Helene Univ. of Miami From owner-chromosomes@net.bio.net Sun Sep 10 23:00:00 1995 Path: biosci!bloom-beacon.mit.edu!newsfeed.internetmci.com!news.sprintlink.net!in1.uu.net!news.compuserve.com!news.production.compuserve.com!news From: Neil Worthington 102705,2475 <102705.2475@CompuServe.COM> Newsgroups: bionet.genome.chromosomes,bionet.immunology Subject: puppet children Date: 11 Sep 1995 01:13:56 GMT Organization: CompuServe, Inc. (1-800-689-0736) Lines: 2 Message-ID: <4302gk$h72$1@mhadf.production.compuserve.com> Xref: biosci bionet.genome.chromosomes:807 bionet.immunology:5402 I am trying to find information on "puppet children" which is refered to as Angelmans syndrome. From owner-chromosomes@net.bio.net Mon Sep 11 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!news.sprintlink.net!in2.uu.net!cadvision.com!usenet From: Jeff Taylor Newsgroups: bionet.genome.chromosomes Subject: DNA Analysis Date: 12 Sep 1995 06:46:31 GMT Organization: CADVision Lines: 13 Message-ID: <433ac7$l30@huey.cadvision.com> NNTP-Posting-Host: cad110.cadvision.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; 68K) X-URL: news:bionet.genome.chromosomes Hi, I'm looking for information on where I can apply my experience in DNA analysis, recombinant DNA techniques, chromosome analysis, etc. in the Calgary area. I have just returned from spending the last 5 years in the UK. Thanks, Hilary J. Taylor (jtaylor@cadvision.com) From owner-chromosomes@net.bio.net Mon Sep 11 23:00:00 1995 Path: biosci!daresbury!nntp-trd.UNINETT.no!Norway.EU.net!EU.net!Germany.EU.net!zib-berlin.de!uni-duisburg.de!sun1.hrz.uni-essen.de!spo3!ttu3a0 From: ttu3a0@spo3.power.uni-essen.de (Bernd Koelsch) Newsgroups: bionet.genome.chromosomes Subject: RAT-POLYMORPHISM Date: 11 Sep 1995 23:49:29 GMT Organization: Universitaet Essen GH, Germany Lines: 20 Message-ID: <432hu9$83f@sun1.uni-essen.de> NNTP-Posting-Host: 132.252.180.3 X-Newsreader: TIN [version 1.2 PL2] Hello everybody Who has information about polymorphism in rats (for LOH detection in tumors) know the MGH/MIT SSLP Map (WWW or Nature Genetics 9,63-69) of the rat with itïs431 (Jan.95) microsatellite repeat markers. But maybe someone knows additional polymorphisms? All data are welcome including RFLPïs, SSCPïs, published or unpublished... Especially information about rat chromosome-10 would be a great help for me! i E-Mail: Bernd.Koelsch@uni-essen.de q q Q ex -r l ly From owner-chromosomes@net.bio.net Tue Sep 12 23:00:00 1995 Newsgroups: bionet.genome.chromosomes Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.mid.net!sbctri.tri.sbc.com!newspump.wustl.edu!news.cellbio.wustl.edu!ntquest!eddy From: eddy@wol.wustl.edu (Sean Eddy) Subject: Re: Info.Request Message-ID: Date: 13 Sep 1995 18:18:59 GMT In-reply-to: Mick's message of 13 Sep 1995 14:51:36 GMT References: <436r5o$8fj@auntie.bbcnc.org.uk> Lines: 22 In article <436r5o$8fj@auntie.bbcnc.org.uk> Mick writes: >Where is all the Human Genome Project results, inc. gene functions ? Um, wait a few years :) Applications for *pilot* human sequencing funds just went into the NCHGR in August, and the funded projects will (officially) begin sequencing in April 1996, I believe. Two sequencing groups have proposed immediately going to full-scale human sequencing, instead of "testing the waters" with smaller pilot projects, but it remains to be seen whether this will happen. But in the meantime, an excellent compilation of URL's relevant to the human genome project can be found at: http://www-ls.lanl.gov/HGhotlist.html -- - Sean Eddy - Dept. of Genetics, Washington University School of Medicine - eddy@genetics.wustl.edu From owner-chromosomes@net.bio.net Tue Sep 12 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!howland.reston.ans.net!swrinde!tank.news.pipex.net!pipex!lade.news.pipex.net!pipex!handbag.tecc.co.uk!usenet From: Mick Newsgroups: bionet.genome.chromosomes Subject: Info.Request Date: 13 Sep 1995 14:51:36 GMT Organization: Nottingham Trent University Lines: 3 Message-ID: <436r5o$8fj@auntie.bbcnc.org.uk> NNTP-Posting-Host: 152.71.6.83 Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; 68K) X-URL: news://news.bbcnc.org.uk/bionet.genome.chromosomes Where is all the Human Genome Project results, inc. gene functions ? From owner-chromosomes@net.bio.net Tue Sep 12 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.sprintlink.net!in1.uu.net!newsflash.concordia.ca!news.mcgill.ca!b-03.das.mcgill.ca!user From: b2d6@musicb.mcgill.ca (Nick Giannoukakis) Newsgroups: bionet.genome.chromosomes,bionet.immunology Subject: Re: puppet children Date: 13 Sep 1995 18:20:59 GMT Organization: McGill University Lines: 29 Message-ID: References: <4302gk$h72$1@mhadf.production.compuserve.com> NNTP-Posting-Host: b-03.das.mcgill.ca Xref: biosci bionet.genome.chromosomes:815 bionet.immunology:5438 In article <4302gk$h72$1@mhadf.production.compuserve.com>, Neil Worthington 102705,2475 <102705.2475@CompuServe.COM> wrote: > I am trying to find information on "puppet children" which is > refered to as Angelmans syndrome. The Angelman syndrome is a neurobehavioral disorder characterised by severe mental retardation, inappropriate laughter, puppetlike movements and mild hypotonia, to mention some symptoms. It is is one of a number of abnormalities that involve genomically imprinted genes Normally, both alleles of a given gene are expressed, but for imprinted genes, the sex of the parent transmitting the allele will dictate whether that allele is expressed or not. Although the phenomenon of imprinting is quite complex, AS results due to the absence of a gene or genes somewhere in 15q11-13, that are expressed from the maternal allele only. This absence is usually due to deletions of the maternal locus or uniparental disomy. For a better description, I highly recommend the following: Genomic imprinting and uniparental disomy in Angelman and Prader-Willi syndromes: a review (1993) Am.J.Med.Genet., 46:16-25 and OMIM: document # 105830 (Online Mendelian Inheritance in Man-I forgot the URL for this, but you can get there by accessing GDB (URL=http://www.gdb.org), selecting GDB browser and from then on OMIM. The interface is very user-friendly). Hope this helps. Nick. From owner-chromosomes@net.bio.net Tue Sep 19 23:00:00 1995 Path: biosci!rutgers!gatech!news.mathworks.com!newsfeed.internetmci.com!news.compuserve.com!news.production.compuserve.com!news From: Matthias Heeder <100104.435@CompuServe.COM> Newsgroups: bionet.genome.chromosomes,bionet.molbio.genome-program,bionet.users.addresses,sci.anthropology Subject: Human Genom Diversity Project Date: 20 Sep 1995 18:37:43 GMT Organization: Rhizomfilm Hamburg Lines: 9 Message-ID: <43pn1n$a9q$1@mhadf.production.compuserve.com> Xref: biosci bionet.genome.chromosomes:816 bionet.molbio.genome-program:1503 bionet.users.addresses:2752 sci.anthropology:16367 I'm desperatly looking for information about the Human Genome Diversity Project. Can anybody help? Or does anybody know of a mailing list covering this subject? Thanks Regards Matthias Heeder 100104.435@compuserve.com -- M.H. From owner-chromosomes@net.bio.net Wed Sep 20 23:00:00 1995 Path: biosci!daresbury!hgmp.mrc.ac.uk!gwilliam From: gwilliam@hgmp.mrc.ac.uk (Gary Williams) Newsgroups: bionet.genome.chromosomes,bionet.molbio.genome-program,bionet.users.addresses,sci.anthropology Subject: Re: Human Genom Diversity Project Date: 21 Sep 1995 08:57:20 GMT Organization: UK HGMP Resource Centre Lines: 40 Message-ID: <43r9dg$e12@mercury.hgmp.mrc.ac.uk> References: <43pn1n$a9q$1@mhadf.production.compuserve.com> NNTP-Posting-Host: gallium.hgmp.mrc.ac.uk Xref: biosci bionet.genome.chromosomes:817 bionet.molbio.genome-program:1505 bionet.users.addresses:2754 sci.anthropology:16375 In article <43pn1n$a9q$1@mhadf.production.compuserve.com>, Matthias Heeder <100104.435@CompuServe.COM> wrote: >I'm desperatly looking for information about the Human Genome >Diversity Project. Can anybody help? Or does anybody know of a >mailing list covering this subject? >Thanks >Regards >Matthias Heeder 100104.435@compuserve.com > >-- >M.H. Matthias, You should look at the "Answers to Frequently Asked Questions About the Human Genome Diversity Project" at the WWW page: http://lotka.stanford.edu/research/diversity.html This should answer most of your questions. This is served from the homepage of Professor L.L. Cavalli-Sforza http://lotka.stanford.edu/ where you will find other interesting information on human population genetics. Gary Williams Computing Services Section, Email: G.Williams@hgmp.mrc.ac.uk MRC Human Genome Mapping Project Resource Centre, Tel: 01223 494522 Hinxton Hall, Hinxton, Cambridge, CB10 1RQ, UK UK MRC HGMP Resource Centre -- GARY WILLIAMS, Internet: G.Williams@HGMP.MRC.AC.UK Tel: 01223 494522 Computing Services, HGMP Resource Centre, Hinxton Hall, Hinxton, Cambridge, CB10 1RQ UK MRC HGMP Resource Centre From owner-chromosomes@net.bio.net Thu Sep 21 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!news.sprintlink.net!in1.uu.net!news1.digital.com!nntp-hub2.barrnet.net!news.Stanford.EDU!law-mac-greely1.stanford.edu!user From: hgreely@leland.stanford.edu (henry t. greely) Newsgroups: bionet.genome.chromosomes Subject: Re: Human Genom Diversity Project Followup-To: bionet.genome.chromosomes,bionet.molbio.genome-program,bionet.users.addresses,sci.anthropology Date: Fri, 22 Sep 1995 11:33:15 -0700 Organization: stanford Lines: 8 Message-ID: References: <43pn1n$a9q$1@mhadf.production.compuserve.com> <43r9dg$e12@mercury.hgmp.mrc.ac.uk> NNTP-Posting-Host: law-mac-greely1.stanford.edu If, after reading the information on Dr. Cavalli-Sforza's web page, you still have questions, please don't hesitate to E Mail them to me. I'm a member of the North American Regional Committee of the Human Genome Diversity Project and I chair the ethics subcommittee for the North American Committee. The Project is still largely in the planning stage, but I'll be happy to talk about it. Hank Greely From owner-chromosomes@net.bio.net Tue Sep 26 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!news.mathworks.com!tank.news.pipex.net!pipex!howland.reston.ans.net!swrinde!emory!nntp.msstate.edu!Isis.MsState.Edu!rda1 From: "Ricky D. Armstrong" Newsgroups: bionet.genome.chromosomes,bionet.molbio.genome-program,bionet.users.addresses,sci.anthropology Subject: Re: Human Genom Diversity Project Date: Wed, 27 Sep 1995 12:11:14 -0500 Organization: Mississippi State University Lines: 3 Message-ID: References: <43pn1n$a9q$1@mhadf.production.compuserve.com> NNTP-Posting-Host: isis.msstate.edu Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=US-ASCII X-Sender: rda1@Isis.MsState.Edu In-Reply-To: <43pn1n$a9q$1@mhadf.production.compuserve.com> Xref: biosci bionet.genome.chromosomes:823 bionet.molbio.genome-program:1514 bionet.users.addresses:2768 sci.anthropology:16463 The information that I have about the Human Genome Project came from the Internet. Use the net search feature or yahoo. From owner-chromosomes@net.bio.net Tue Sep 26 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!newsfeed.internetmci.com!usenet.eel.ufl.edu!tank.news.pipex.net!pipex!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: cpor2000@aol.com (CPOR2000) Newsgroups: bionet.genome.chromosomes Subject: Genome in relation to Epidemiology Date: 27 Sep 1995 18:32:17 -0400 Organization: America Online, Inc. (1-800-827-6364) Lines: 9 Sender: root@newsbf02.news.aol.com Message-ID: <44cjdh$gsh@newsbf02.news.aol.com> Reply-To: cpor2000@aol.com (CPOR2000) NNTP-Posting-Host: newsbf02.mail.aol.com I am a sophomore high school student looking for information on a project. It is titled "Epidemiology In Relation to the Human Genome" If anyone can give me information or resources you will be added to the bibliography. As soon as the report is finished (Current estimate around 25pp.) it will be posted in all Genome Newsgroups. Thanks in advance. Klofkorn From owner-chromosomes@net.bio.net Tue Sep 26 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!news.sprintlink.net!wizard.pn.com!Germany.EU.net!howland.reston.ans.net!news-e1a.megaweb.com!newstf01.news.aol.com!newsbf02.news.aol.com!not-for-mail From: nsuyeda@aol.com (N S Uyeda) Newsgroups: bionet.genome.chromosomes Subject: chromosome six Date: 27 Sep 1995 01:02:59 -0400 Organization: America Online, Inc. (1-800-827-6364) Lines: 13 Sender: root@newsbf02.news.aol.com Message-ID: <44alu3$156@newsbf02.news.aol.com> Reply-To: nsuyeda@aol.com (N S Uyeda) NNTP-Posting-Host: newsbf02.mail.aol.com A friend's amniocentesis shows an abnormal wide band on six. The lab's first response is to test the parents for a familial trait. If that's not the case are possible consequences completely unknown? My friend was told that they have not seen a band like it before on that chromosome and it has not been reported in the literature. Would appreciate any thoughts/opinions on how to get more information. I guess similar bands on other chromosomes can result in neurological damage, so we wonder if that translates to a similar scenario in this case too. These are normal, healthy parents with a normal sonogram. Appreciate any feedback. Susan From owner-chromosomes@net.bio.net Wed Sep 27 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.msfc.nasa.gov!cs.utk.edu!gatech!newsxfer.itd.umich.edu!news.flint.umich.edu!news.gmi.edu!usenet.eel.ufl.edu!tank.news.pipex.net!pipex!wave.news.pipex.net!pipex!dish.news.pipex.net!pipex!plug.news.pipex.net!pipex!oleane!jussieu.fr!univ-lyon1.fr!in2p3.fr!swidir.switch.ch!newsfeed.ACO.net!Austria.EU.net!EU.net!howland.reston.ans.net!ix.netcom.com!netnews From: quantum2@ix.netcom.com (STEVEN SOBEL) Newsgroups: bionet.genome.chromosomes Subject: Homosexuality and genetics Date: 28 Sep 1995 02:21:37 GMT Organization: Netcom Lines: 3 Message-ID: <44d0rh$s2v@ixnews3.ix.netcom.com> NNTP-Posting-Host: ix-la3-12.ix.netcom.com X-NETCOM-Date: Wed Sep 27 7:21:37 PM PDT 1995 We are looking for info. on what role, if any, genetics may have in sexual development and orientation. Thanks. From owner-chromosomes@net.bio.net Wed Sep 27 23:00:00 1995 Path: biosci!RESUNIX.RI.SICKKIDS.ON.CA!jlight From: jlight@RESUNIX.RI.SICKKIDS.ON.CA (Dr. Jeff Lightfoot) Newsgroups: bionet.genome.chromosomes Subject: cDNA libraries for human chromosomes Date: 28 Sep 1995 14:58:37 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 5 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Does anyone know if full-length cDNA libraries are available for individual human chromosomes? If not available, does anyone know of someone who's working on it? Thanks for the help. Jeff. From owner-chromosomes@net.bio.net Wed Sep 27 23:00:00 1995 Path: biosci!bcm.tmc.edu!news.tamu.edu!news.utdallas.edu!news.starnet.net!wupost!ukma!usenet.eel.ufl.edu!spool.mu.edu!howland.reston.ans.net!ix.netcom.com!netnews From: mckierke@ix.netcom.com (Kevin E. McKiernan ) Newsgroups: bionet.genome.chromosomes Subject: genetic mutations Date: 28 Sep 1995 04:44:35 GMT Organization: Netcom Lines: 7 Message-ID: <44d97j$i86@ixnews6.ix.netcom.com> NNTP-Posting-Host: ix-lou-ky2-11.ix.netcom.com X-NETCOM-Date: Wed Sep 27 9:44:35 PM PDT 1995 I am trying to understand the concept of "spontaneous genetic mutation." Assuming such, when, during human development, might such a mutation take place? During entire gestation period, or during the first few hours, days, weeks, months? Thanks for any help. Kevin McKiernan From owner-chromosomes@net.bio.net Thu Sep 28 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!news.sprintlink.net!in1.uu.net!cadvision.com!usenet From: Jeff Taylor Newsgroups: bionet.genome.chromosomes Subject: Re: Chromosome Six Date: 29 Sep 1995 22:47:04 GMT Organization: CADVision Lines: 46 Message-ID: <44ht18$1vv2@huey.cadvision.com> NNTP-Posting-Host: cad125.cadvision.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1N (Macintosh; I; 68K) X-URL: news:bionet.genome.chromosomes nsuyeda@aol.com on 29-Sept-95 writes: >A friend's amniocentesis shows an abnormal wide band on six. The lab's >first response is to ....... -=-=-=-=-=-=-=-=-=-=-=-=-=-=-=- This is regarding your question about your friend's amniocentesis. There is a question I would have for you (or her). If they are normal, healthy parents with a normal sonogram why have they had an amnio? I am going to assume the answer to this is because of the mother's age. You say there is a band that is wider than normal. (It would help immensely to know which band). This basically means there is extra DNA present. There are 2 possibilities: 1) The extra DNA does not contain any genes (nor affect any genes normally present in this region). There would most likely be no repercussions to the baby. The only way of knowing this for sure is if one of the parents has the same anomaly. That is why the first thing the lab is doing is to test the parents. 2) The extra DNA contains genes. If this is the case then the baby has one too many copies of the extra gene(s). Because a chromosome analysis is looking for gross chromosomal abnormalities, the fact that they have found something means that there is a lot of extra DNA. This is not good news. To do any kind of research you would have to know the specific band on chromosome 6 that is affected and then go to a medical library (most universities have one). You would then have to check the literature to see if there are any reported cases of people having extra DNA (trisomy) in this band. To date 23 patients with partial trisomy of the long arm of chromosome 6 have been reported. These all involve duplication of more than a single band so are more severe than what you say is a single abnormal wide band. Therefore it is impossible to speculate on your case. The best news would be for one of the parents to have the same phenomenon. Otherwise, I feel there may very well be physical and/or neurological problems. Hilary Taylor (MSc Human & Medical Genetics) From owner-chromosomes@net.bio.net Thu Sep 28 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!news.sprintlink.net!in1.uu.net!newsflash.concordia.ca!news.mcgill.ca!news From: Graham Dellaire Newsgroups: bionet.genome.chromosomes Subject: Re: genetic mutations Date: 29 Sep 1995 21:26:42 GMT Organization: McGill University Computing Centre Lines: 28 Message-ID: <44hoai$p3i@sifon.cc.mcgill.ca> References: <44d97j$i86@ixnews6.ix.netcom.com> NNTP-Posting-Host: b-06.das.mcgill.ca X-Newsreader: AIR News 3.X (SPRY, Inc.) > mckierke@ix.netcom.com (Kevin E. McKiernan ) writes: > I am trying to understand the concept of "spontaneous genetic > mutation." Assuming such, when, during human development, might such a > mutation take place? During entire gestation period, or during the > first few hours, days, weeks, months? > > Thanks for any help. > Kevin McKiernan > >>>> Mutations are able to occur even right now in your mature cells dividing mitotically.... sometimes this is how cancers develop. Now if they are to be hereditarily conserved mutations, they need to occur in your gamete producing cells (testes or ovaries depending on your gender) or at an early enough time in embryo genesis (or even in your father/mothers gamete s before the zygote was formed) to be transfered to cells that are precursors for the cells in your testes or ovaries that produce gametes. Basically "spontaneous" mutation can occur any time. The are particular times (or tissue in which) when mutations may occur at a higher frequency. Any cell that is rapidly dividing, such as an embryo, can run the chance of missing a mispaired base and permanently producing a change in its DNA. Skin cells for example also are rapidly dividing and are therefore more likely to incurr mutations in their DNA. Environmental mutagens, UV light for example, can increase the amount of damage to DNA and thus the chance of not repairing it. I hope that gets you started G. From owner-chromosomes@net.bio.net Fri Sep 29 23:00:00 1995 Path: biosci!biosci!not-for-mail From: malik@ebi.ac.uk (Ansar Malik) Newsgroups: bionet.immunology,bionet.general,bionet.microbiology,bionet.genome.chromosomes Subject: ANNOUNCE: IMMUNOGENETICS (IMGT)/LIGM DATABASE Date: 29 Sep 1995 23:56:47 -0700 Organization: European Bioinformatics Institute (EMBL) - UK Lines: 63 Sender: biohelp@net.bio.net Distribution: world Message-ID: Reply-To: malik@ebi.ac.uk (Ansar Malik) NNTP-Posting-Host: net.bio.net Keywords: database,immunogenetics,immunoglobulin genes,T cell receptor genes, sequence annotation Xref: biosci bionet.immunology:5649 bionet.general:17425 bionet.microbiology:3446 bionet.genome.chromosomes:830 IMMUNOGENETICS (IMGT)/LIGM DATABASE Professor Marie-Paule LEFRANC Laboratoire d'ImmunoGenetique Moleculaire, LIGM UMR CNRS 9942, Institut de Genetique Moleculaire BP 5051, 1919 route de Mende, 34033 MONTPELLIER Cedex 1 FRANCE Telephone: (33) 67 61 36 34 FAX : (33) 67 04 02 31/67 04 02 45 e-mail : lefranc@ligm.crbm.cnrs-mop.fr INTRODUCTION ================ The ImMunoGeneTics database, IMGT, is an integrated specialised database containing nucleotide sequence information of genes important in the function of the immune system. It collects and annotates sequences belonging to the immunoglobulin superfamily which are involved in immune recognition, these are the B cell antigen receptor (Immunoglobulin or Ig), the T cell antigen receptor (TcR) (LIGM-database) and the class I and class II molecules of the Human Leucocyte Antigens (HLA) system (HLA-database). IMGT/LIGM DATABASE =================== An integrated immumogenetics database (IMGT/LIGM) specialising in Ig and TcR is under development through collaboration between LIGM, IFG and EMBL oustation EBI. This database consists of the Ig and TcR sequence entries. Collaborators: LIGM Montpellier :Marie-Paule Lefranc (coordinator) Veronique Giudicelli,Denys Chaume EMBL-EBI :Ansar Malik IFG :Werner Mueller MRC :Ian Tomlinson ACCESS/DATA DISTRIBUTION ========================== Access the IMGT server at url: http://www.ebi.ac.uk/contrib/imgt/top_imgt.html IMGT database An alternative method of accessing the database is to use the Internet file transfer protocol (ftp). Researchers with direct access to the Internet can use the FTP program on their local machine to connect to the host FTP.EBI.AC.UK and enter the user name "anonymous" and their email address as password. The directory pub/help contains detailed information about the data available from the EBI anonymous FTP server. IMGT/LIGM database is available >From the following directory IMGT/LIGM quarterly release: pub/databases/imgt This database is available on CD-ROM as an acompanying database to the EMBL Nucleotide Sequence Database at nominal cost. ----------------------------------------------------------------------------- _________________________________ |Ansar Malik | |_________________________________| |Telephone: +44 (1223) 494417 | |Telefax: +44 (1223) 494968 | |email: Malik@ebi.ac.uk | --------------------------------- From owner-chromosomes@net.bio.net Sat Sep 30 23:00:00 1995 Path: biosci!bcm.tmc.edu!cs.utexas.edu!howland.reston.ans.net!swrinde!tank.news.pipex.net!pipex!soap.news.pipex.net!pipex!usenet From: M J Geisow Newsgroups: bionet.genome.chromosomes Subject: Celebration of completion of yeast genome in Monpellier, March 1996 Date: 1 Oct 1995 10:40:40 GMT Organization: UnipalmPIPEX server (post doesn't reflect views of UnipalmPIPEX) Lines: 26 Message-ID: <44lr78$b4a@soap.news> NNTP-Posting-Host: am079.du.pipex.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 1.1 (Windows; I; 16bit) If you are thinking of applying for a grant in the EU Fourth Framework (Structural Biology Area) You might like to read the World Wide Web document: http://www.cryst.bbk.ac.uk/CEC/cec.html This was prepared as a concise summary for UK applicants and was checked by the European Commission. Please also note that the scientific programme for the major international Protein Engineering meeting in Montpellier, France 2-6 March 1996 is now finalised. A CEC GRANT has been applied for to support attendance by all 151 Framework 3 Structural Biology grant holders. Information and registration at: http://www.cryst.bbk.ac.uk/CEC/pope5.html Finally, note that there is now a CALENDAR of World Structural Biology Events at: http://www.cryst.bbk.ac.uk/CEC/calendar.html NOTE: PLEASE ENTER THE ADDRESSES PRESERVING THE LETTER CASE AS SHOWN. M J Geisow Sept 1995 UK LINK Protein Engineering Programme Co-ordinator