From owner-chromosomes@net.bio.net Mon Feb 01 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!netnews.netreach.net!usenet From: "scott" Newsgroups: bionet.genome,bionet.genome.chromosomes,bionet.immunology,bionet.journals,bionet.microbiology Subject: US-MD LABORATORY SPACE for LEASE Date: Mon, 1 Feb 1999 22:03:15 -0800 Organization: NetReach InterNetNews Lines: 17 Message-ID: <795q9u$io4$4@tikehau.netreach.net> NNTP-Posting-Host: ppp-207022-102.netreach.net X-Newsreader: Microsoft Outlook Express 4.72.3110.5 X-Mimeole: Produced By Microsoft MimeOLE V4.72.3110.3 Xref: biosci bionet.genome.chromosomes:2278 bionet.immunology:15636 bionet.microbiology:15714 AMAZING LAB SPACE in BALTIMORE, MARYLAND Pharmaceutical Research & Development Facility AVAILABLE FOR IMMEDIATE LEASE >Lab space from 500-1,000-5,000-20,000-64,000 SF >Prices from $25-$40 Per Square Foot >Full service, Turn-key Labs >Short & Long Term Leases Available For More Information CALL: Rob Freedman Corridor Commercial Real Estate Group, Inc. (410) 363-9500 x109 corridorre@aol.com From owner-chromosomes@net.bio.net Tue Feb 02 22:00:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!newsfeed.cwix.com!208.137.248.9!news1.abac.com!not-for-mail From: Robert Byrnes Newsgroups: bionet.genome.chromosomes Subject: Re: bioinformatics Date: Wed, 03 Feb 1999 12:00:52 -0600 Organization: A+Net Lines: 27 Message-ID: <36B88ED4.6A934C2A@abac.com> References: <8f1d9e63.36b373c8@aol.com> NNTP-Posting-Host: sd-ppp-150.abac.net Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.05 [en] (Win95; I) Jilko-- I am interested in bioinformatics. I recently participated in 2 courses/workshops at the University of California-San Diego in the subject. I am also currently studying C++ and Visual C++ for the purpose. There are easier programming languages to learn, but I like a challenge. Is this an appropriate newsgroup for a discussion like this? Does anyone have another suggestion? --Bob Byrnes JILKO1@AOL.COM wrote: > Hi there > > Does anyone know of anything of interest to do with bioinformatics > > Thanks > > Jilko From owner-chromosomes@net.bio.net Wed Feb 03 22:00:00 1999 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.gtei.net!newsfeed.cwix.com!209.208.190.2!news.globix.net!uunet!ffx.uu.net!in5.uu.net!stalker.oem.net!not-for-mail From: "Sean" Newsgroups: bionet.genome.chromosomes Subject: 16 bit and new Karyo II cytogeneics Date: Fri, 29 Jan 1999 04:39:53 -0500 Organization: oemnetworks.com Lines: 29 Message-ID: <36b0e64b.0@rboc1.prime-x.net> NNTP-Posting-Host: rboc1.prime-x.net X-Trace: stalker.oem.net 918155255 10682 209.113.154.11 (4 Feb 1999 19:07:35 GMT) X-Complaints-To: usenet@stalker.oem.net NNTP-Posting-Date: 4 Feb 1999 19:07:35 GMT X-Newsreader: Microsoft Outlook Express 4.72.2106.4 X-MimeOLE: Produced By Microsoft MimeOLE V4.72.2106.4 Comparison Table of Gel Doc , Chemiluminescence & Microscopy with Cooled integrating 16-bits Monochrome & 24-bits color. Biostorm Cooled Integrating CCD video Camera 16-bits 8-bits Resolution, Gray levels 65,356 256 Max. integration time , Gel Documentation with UV transilluminator, (background cause bleaching) 40 seconds 3 seconds Max Integration time, Chemiluminescence, No UV Transilluminator. (Dark current cause bleaching), 90 minutes 5 minutes Upgrade for any system:CCD, grabber, on-chip software $5,365(16-bits) $5,950(8-bits) Chemi-16 system, complete system $16,995 Over $18,950 24-bits color cooled CCD with grabber interface $5,895 $5,950 (not cooled) From owner-chromosomes@net.bio.net Fri Feb 05 22:00:00 1999 Path: biosci!ILOILO.WORLDTELPHIL.COM!cads From: cads@ILOILO.WORLDTELPHIL.COM ("Cads Savillo") Newsgroups: bionet.genome.chromosomes Subject: The Law will soon bow to Genetics Date: 6 Feb 1999 05:56:30 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Distribution: world Message-ID: <199902061353.VAA11266@magayun.iloilo.worldtelphil.com> NNTP-Posting-Host: net.bio.net The Law will soon bow to Genetics As the saying goes "Individuals donot evolve* but population do". We are imprisoned in the Genetic materials that our parents gave unto us through the unity of their haploid gametes to produce the diploid us. At present, the Human Chromosomal Mapping is on going by the developed countries.. Subsequently as I believe the phenotypic bearing of each gene will soon be revealed though regulatory (the extent of its power to promote or its constitutive flow , etc.) or structural. Genes that are environmentally prone for their activities will soon shed light to the badness and goodness of an individual. Phenotypically bad because of his/her bad/poor or the like type of milieu.. Phenotypically good because of his "good"/rich environment where bad characters could be masked as they could be bought by cosmetic genetics ( behavioral or physical). But who these good/learned individuals say that they have the power to judge the poor in their own rich living room...the influence to their genes which mold their character are not the same as that of the poor/bad... Genetics will soon sum up the totality of an individual and will reprieve individuals from the penalty that law has unfairly given them. *Our lifespan is too short to accommodate natural selection. I. Savillo Asst. Prof. From owner-chromosomes@net.bio.net Sat Feb 06 22:00:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!netnews.com!news2.euro.net!newsreader.euronet.nl!news3.euro.net!usenet From: "Jean Jacques s'Jongerd" Newsgroups: bionet.genome.chromosomes Subject: to the group:possible effects of drugs on the genome Date: 7 Feb 1999 21:10:34 GMT Organization: EuroNet Internet Lines: 6 Message-ID: <79kvga$cit@news3.euro.net> NNTP-Posting-Host: i019.bru.euronet.be X-Newsreader: Microsoft Outlook Express 4.72.3110.5 X-MimeOLE: Produced By Microsoft MimeOLE V4.72.3110.3 several papers seem to show a pathogenic effect of drugs(namely cannabis) on the animal, or on the human genome .several others don't.The advise of the experts on drugs and the maining about this problem from the geneticians would be appreciated.Thanks a lot .with my best regards. 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Ave S, Suite B-102, Palmdale, CA 93552=20 Name______________________________ Address____________________________ Address____________________________ City, State, Zip_______________________ Email Address_______________________ From owner-chromosomes@net.bio.net Wed Feb 10 22:00:00 1999 Path: biosci!news.stanford.edu!nntp.stanford.edu!not-for-mail From: mario pedrazzoli Newsgroups: bionet.genome.chromosomes Subject: Moderator? Date: Thu, 11 Feb 1999 11:14:31 +0000 Organization: Stanford University Lines: 7 Message-ID: <36C2BB95.6A66@leland.stanford.edu> References: <79s5kp$mla$1@mserv2.dl.ac.uk> Reply-To: pedrazzo@stanford.edu NNTP-Posting-Host: p124-performa.stanford.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 3.04 (Macintosh; I; PPC) The low traffic flow on this group is fine with me, although it would be nice to have more interesteing discussions. I'm tired of junk postings of get-rich schemes. Shall we investigate making this group into a moderated group? J. Faraco From owner-chromosomes@net.bio.net Wed Feb 10 22:00:00 1999 Path: biosci!SILVA.TAMU.EDU!jvb From: jvb@SILVA.TAMU.EDU ("Dr. van Buijtenen") Newsgroups: bionet.genome.chromosomes Subject: Re: Moderator? Date: 11 Feb 1999 13:53:35 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 14 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <36C2BB95.6A66@leland.stanford.edu> NNTP-Posting-Host: net.bio.net Sounds like a good idea. It just might promote good discussions as well. J.P. van Buijtenen On Thu, 11 Feb 1999, mario pedrazzoli wrote: > The low traffic flow on this group is fine with me, although it would be > nice to have more interesteing discussions. > > I'm tired of junk postings of get-rich schemes. Shall we investigate > making this group into a moderated group? > > J. Faraco > From owner-chromosomes@net.bio.net Thu Feb 11 22:00:00 1999 Path: biosci!MYMAIL.COM!petercobalt From: petercobalt@MYMAIL.COM Newsgroups: bionet.genome.chromosomes Subject: Maximize Your Website Traffic! Date: 12 Feb 1999 00:50:59 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 270 Sender: daemon@net.bio.net Distribution: world Message-ID: <199902121329OAA43054@post.tzm.it> NNTP-Posting-Host: net.bio.net Maximize your website's traffic. INCREASE YOUR SEARCH ENGINE RANK! If your Web site isn't getting the traffic it should, it's likely that it's not ranked well on the major Internet search engines. According to recent Internet E-commerce studies, over 90% of consumers find the Web sites they visit by using eight major search engines, which are Yahoo!, Excite, AltaVista, Infoseek, Lycos, Web Crawler, HotBot, and Northern Light. If your website isn't located in the top-30 listings of these engines, chances are your site will never be seen. 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Ever. ------------ CONTACT A REPRESENTATIVE: Search Engine Success Group - Call us at: (888) 283-2050 ----------------------- If you've received this message in error--and are not interested in our services--please click reply or call, (888)-248-2236, and we'll remove you from our list. 7 From owner-chromosomes@net.bio.net Thu Feb 11 22:00:00 1999 Path: biosci!MAILHOST.TCS.TULANE.EDU!alustig From: alustig@MAILHOST.TCS.TULANE.EDU ("Lustig, Arthur J.") Newsgroups: bionet.genome.chromosomes Subject: Telomeres at Tulane Date: 12 Feb 1999 12:25:13 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 42 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net POSTDOCTORAL FELLOWS TO STUDY TELOMERE STRUCTURE AND FUNCTION A postdoctoral position is available to investigate telomere dynamics in Saccharomyces cerevisiae in the laboratory of Dr. Arthr J. Lustig at Tulane University Medical Center. We have had a long-standing fascination in telomere structure and function and are currently focusing on two broad areas: 1) THE MECHANISM OF TELOMERIC SILENCING RECENT REFERENCES Park et al., Sir3p Domains Involved in the Initiation of Telomeric Silencing in Saccharomyces cerevisiae. Genetics 150: 977-986 (1998); Lustig, A., Mechamisms of silencing in Saccharomyces cerevisiae. Current Opinions in Gentetics and Development 8: 233-239 (1998) and 2) THE MECHANISM OF TELOMERE SIZE CONTROL RECENT REFERENCES Li et al. A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev. 10: 1310-1326 (1996); Lustig, A. The identification of telomerase subunits: catalysing telomere research. 7:299-302 (1997); Polotnianka et al. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Current Biology 831-834 (1998) Candidates should have a background in molecular biology and/or genetics. Background in yeast is preferable but not required. Applicants must be highly motivated "self-starters". Interested candidates should send their c.v. either by e-mail, fax, or mail to the address listed below. Dr.Arthur J. Lustig Associate Professor 1430 Tulane Avenue Tulane University Medical Center New Orleans, LA 70112 phone: 504-584-3688 fax: 504-584-2739 From owner-chromosomes@net.bio.net Thu Feb 11 22:00:00 1999 Path: biosci!vt.edu!dwnorow From: dwnorow@vt.edu (Dennis Wnorowski) Newsgroups: bionet.genome.chromosomes Subject: Translocated Chromosomes Date: 12 Feb 1999 12:13:04 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 6 Sender: daemon@net.bio.net Distribution: world Message-ID: <3.0.6.32.19990212150710.007babd0@mail.vt.edu> NNTP-Posting-Host: net.bio.net Our unborn child has recently been diagnosed with reciprocally translocated chromosomes for Chromosomes number 4 and 18. I was wondering if you had any information on this. 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Date: 15 Feb 1999 23:23:57 -0000 Organization: Daresbury Laboratory, Warrington, U.K. Lines: 7 Message-ID: <7aaaad$6dv$1@mserv2.dl.ac.uk> NNTP-Posting-Host: mserv2.dl.ac.uk content-length: 462 Return-Path: Apparently-To: Start Earning a Nice Steady Income GUARANTEED or Your Money Back !!! With a REAL BUSINESS as a licensed associate of a Very Unusual FREE monthly shopping paper. Sixteen years of successful local operation, now expanding nationwide. Only $29 gets you started. No Selling, No Mail-outs, No Advertising and No MLM. You can easily earn $900-$1200 per week with this genius, honest business. Complete recorded details 24 hours at 1-800-350-9692 or 281-315-1069. From owner-chromosomes@net.bio.net Sun Feb 14 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!nntp.news.xara.net!xara.net!server6.netnews.ja.net!daresbury!not-for-mail From: Froggy1704@aol.com Newsgroups: bionet.genome.chromosomes Subject: Need new ID? Privacy? 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Please PRINT your address so we do not get it wrong and cause delay in your product. For best results write your address TWICE so we can make sure we get it right. From owner-chromosomes@net.bio.net Sun Feb 14 22:00:00 1999 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!news.gtei.net!newsfeed.corridex.com!newsfeed.cwix.com!152.163.199.19!portc03.blue.aol.com!audrey01.news.aol.com!not-for-mail From: rcjohnsen@aol.com (Rcjohnsen) Newsgroups: bionet.genome.chromosomes Subject: Re: Translocated Chromosomes Lines: 14 NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com Date: 15 Feb 1999 21:18:12 GMT Organization: AOL http://www.aol.com References: <3.0.6.32.19990212150710.007babd0@mail.vt.edu> Message-ID: <19990215161812.25050.00002050@ng61.aol.com> My deceased wife worked for a Genetic Center on Long Island. She might be able to help you for she is an expert in the field of translocated chromosomes. You would, however, have to know the exact breakpoints on chromosomes 4 & 18. There may be a fee for her time but you will have to determine if that is the route you want to go. Her e-mail address is Ctrunca@scls1.suffolk.lib.ny.us Rcjohnsen@aol.com Portland, Or << Our unborn child has recently been diagnosed with reciprocally translocated chromosomes for Chromosomes number 4 and 18. I was wondering if you had any information on this. >> From owner-chromosomes@net.bio.net Mon Feb 15 22:00:00 1999 Path: biosci!sfu.ca!tzeng From: tzeng@sfu.ca (Tao Zeng) Newsgroups: bionet.genome.chromosomes Subject: How to unsubscribe? Date: 15 Feb 1999 16:32:38 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 4 Sender: daemon@net.bio.net Distribution: world Message-ID: References: <7aaajt$6qj$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Anybody can tell me how to sign-out this news group? Thanks! tao From owner-chromosomes@net.bio.net Mon Feb 15 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!newsfeed.cwix.com!146.80.9.55!diablo.dera.gov.uk!server1.netnews.ja.net!server2.netnews.ja.net!news.reading.ac.uk!not-for-mail From: Alexandra Elizabeth Baker Newsgroups: bionet.genome.chromosomes Subject: university project Date: Tue, 16 Feb 1999 17:41:36 +0000 Organization: University of Reading Lines: 10 Message-ID: <36C9ADD0.FAC43113@rdg.ac.uk> NNTP-Posting-Host: supc498.reading.ac.uk Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.06 [en] (Win95; I) Hello, my name is Alex and at the moment I am in my second year of university at Reading, UK. Myself and 4 others are currently trying to research for a project called, "Should Research money be spent on sequencing Genomes of organisms?" We need to know the possible and likely medical uses of this information; and would the monnies be better spent in other ways? At the moment I am trying to fing out about the methods of sequencing genomes and the history of genome sequencing. Can you help? Alex Baker From owner-chromosomes@net.bio.net Mon Feb 15 22:00:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!btnet-peer!btnet!nntp.news.xara.net!xara.net!server6.netnews.ja.net!singer.cent.gla.ac.uk!secretary1.ibls.gla.ac.uk!user From: rh@mblab.gla.ac.uk (Robert Hartley ) Newsgroups: bionet.genome.chromosomes Subject: Re: How to unsubscribe? Date: Tue, 16 Feb 1999 09:11:18 +0000 Organization: University of Glasgow Lines: 24 Distribution: world Message-ID: References: <7aaajt$6qj$1@mserv2.dl.ac.uk> NNTP-Posting-Host: secretary1.ibls.gla.ac.uk In article , tzeng@sfu.ca (Tao Zeng) wrote: > Anybody can tell me how to sign-out this news group? Thanks! > Depends what machine and newsreader. EG this is a Mac and running the old Newsreader. I have an Acorn Risc also running newsbase/ttfn with Drag and drop editing. however the general command is "control"U. If you are running windows? Sorry I cant help, I don't use the OS. PS: Remember to save the changes. :-) > tao Cheers Bob -- Robert Hartley BSc. Centre for Cell Engineering, IBLS Division of Infection & Immunity, University of Glasgow, E-Mail rh@mblab.gla.ac.uk *Not*@secretary1.ibls.gla.ac.uk (I just got her old Mac for my lab) From owner-chromosomes@net.bio.net Wed Feb 17 22:00:00 1999 Path: biosci!SLIP.NET!grizzly From: grizzly@SLIP.NET (Michael Sherrell) Newsgroups: bionet.genome.chromosomes Subject: ABI 377 for sale Date: 18 Feb 1999 15:55:29 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 38 Sender: daemon@net.bio.net Distribution: world Message-ID: <01BE5B56.79278220@oak-hiper1a-41-105.dialup.slip.net> NNTP-Posting-Host: net.bio.net Newly for sale: ABI 377 DNA sequencer, XL, 96 lanes, under transferrable Perkin Elmer service contract until March 2000. Price: $105,000. 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From owner-chromosomes@net.bio.net Fri Feb 19 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!nntp.news.xara.net!xara.net!server5.netnews.ja.net!daresbury!not-for-mail From: RSTANR@aol.com Newsgroups: bionet.genome.chromosomes Subject: question Date: 20 Feb 1999 05:46:22 -0000 Organization: Daresbury Laboratory, Warrington, U.K. Lines: 20 Message-ID: <7ali7e$cj3$1@mserv2.dl.ac.uk> NNTP-Posting-Host: mserv2.dl.ac.uk content-length: 463 Return-Path: Apparently-To: UNIVERSITY DEGREE PROGRAMS Increase your personal prestige and money earning power through an advanced university degree. Eminent, non-accredited universities will award you a degree for only $200. Degree granted based on your present knowledge and experience. No further effort necessary on your part. Just a short phone call is all that is required for a BA, MA, MBA, or PhD diploma in the field of your choice. For details, call 602-230-4252 From owner-chromosomes@net.bio.net Sun Feb 21 22:00:00 1999 Path: biosci!news.stanford.edu!su-news-feed2.bbnplanet.com!su-news-hub1.bbnplanet.com!cpk-news-hub1.bbnplanet.com!news.gtei.net!news-peer.gip.net!news.gsl.net!gip.net!portc01.blue.aol.com!audrey03.news.aol.com!not-for-mail From: brookie624@aol.com (Brookie624) Newsgroups: bionet.genome.chromosomes Subject: Hey PLEASE SOMEBODY ANWSER THIS!!! Lines: 7 NNTP-Posting-Host: ladder03.news.aol.com X-Admin: news@aol.com Date: 22 Feb 1999 23:54:49 GMT Organization: AOL http://www.aol.com Message-ID: <19990222185449.02887.00001811@ng-fx1.aol.com> ok I need to know the anwser to this.. IN X AND Y CHROMOSOMES WHICH IS THE MALE AND WHICH IS THE FEMALE...??? Thanx, Brooke P.S. Please anwser I am confused From owner-chromosomes@net.bio.net Mon Feb 22 22:00:00 1999 Path: biosci!news.stanford.edu!logbridge.uoregon.edu!newsswitch.lcs.mit.edu!news-spur1.maxwell.syr.edu!news.maxwell.syr.edu!news-peer.gip.net!news.gsl.net!gip.net!portc01.blue.aol.com!spamz.news.aol.com!audrey01.news.aol.com!not-for-mail From: rcjohnsen@aol.com (Rcjohnsen) Newsgroups: bionet.genome.chromosomes Subject: Re: Hey PLEASE SOMEBODY ANWSER THIS!!! Lines: 4 NNTP-Posting-Host: ladder01.news.aol.com X-Admin: news@aol.com Date: 23 Feb 1999 22:32:36 GMT Organization: AOL http://www.aol.com References: <19990222185449.02887.00001811@ng-fx1.aol.com> Message-ID: <19990223173236.01126.00001768@ng-fp1.aol.com> The male sex determining gene is located on the short arm of the Y chromosome. However there are XX males where the male sex determining gene appears to have been been relocated to the X, and XY females where the males sex determining factor has been removed or inactivated. And ther are other exceptions. From owner-chromosomes@net.bio.net Mon Feb 22 22:00:00 1999 Path: biosci!WRITEME.COM!rollin From: rollin@WRITEME.COM Newsgroups: bionet.genome.chromosomes Subject: 10th ICGGFI. Date: 23 Feb 1999 13:04:44 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 44 Sender: daemon@net.bio.net Distribution: world Message-ID: <36D317E5.6E38C4E1@writeme.com> NNTP-Posting-Host: net.bio.net 10th International Congress on Genes, Gene Families and Isozymes --Advances in Genome Research and Their Implications for Biology in 21st Century October 5-10, 1999 Beijing, China Provisional Topics: 1. Genomes and Bioinformatics; 2. Novel Approaches to Functional Dissection of Genes; 3. Chromosome: Structure and Function; 4. Practical and Ethical Implications of Genome Research; 5. Evolution of Patterns and Forms; 6. Epigenetic Processes in Development; 7. Programmed Cell Death; 8. Signalling: Pathways, Cascades and Integration; 9. Genes and Diseases; 10. Transgenesis; 11. Evolution and Function of Isozymes; 12. Biotechnology; 13. Environmental Biology; 14. Germplasm and Biodiversity. Sponsors: Institute of Developmental Biology, Chinese Academy of Sciences Changjiang Fishery Research Institute, Chinese Academy of Fishery Sciences Co-Sponsor: Chinese Committee for International Union of Biological Sciences For more information about supporting and particitation, please contact; ********************************************************* BILONG Transgenics----A Creative Group for Transgenics Add: 8 Nan Er Jie, Zhong Guan Cun, Beijing 100080, China Box: P.O. Box 8734, Beijing 100080, China Tel: 86-10-6256-0561, 6256-2226 Ext 211, 800-810-0797 Fax: 86-10-6253-2114 Email: info@bilong.com Website: www.bilong.com ********************************************************* From owner-chromosomes@net.bio.net Tue Feb 23 22:00:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!newsfeed.tli.de!newsfeed.ecrc.net!158.43.192.39.MISMATCH!eyre.news.pipex.net!pipex!news100.image.dk!news020.image.dk.POSTED!not-for-mail From: "don_morfar" Newsgroups: bionet.genome.chromosomes Subject: can somebody figure this out? Lines: 13 X-Newsreader: Microsoft Outlook Express 4.72.3110.5 X-MimeOLE: Produced By Microsoft MimeOLE V4.72.3110.3 Message-ID: <6ZVA2.96$XD3.305@news020.image.dk> Date: Wed, 24 Feb 1999 17:33:55 +0100 NNTP-Posting-Host: 194.234.172.67 X-Complaints-To: news-abuse@image.dk X-Trace: news020.image.dk 919874498 194.234.172.67 (Wed, 24 Feb 1999 17:41:38 MET DST) NNTP-Posting-Date: Wed, 24 Feb 1999 17:41:38 MET DST suppose that u discover two interesting rare cytological abnormalities in the karyotype of a human male. There is an extra piece(sattelite) on one of the chromosomes of pair 4, and there is an abnormal pattern of staining on one of the chromosomes of pair 7. assuming that all the gametes of this male is equally viable, what proportion of his children will have the same karyotype as he has? If u can figure it out i would be gratefull if u would mail the answer to me + an explanation on how u worked it out. Thanks in advance ...............Mads Marquardt@image.dk From owner-chromosomes@net.bio.net Tue Feb 23 22:00:00 1999 Path: biosci!news.stanford.edu!logbridge.uoregon.edu!newsswitch.lcs.mit.edu!netnews.com!howland.erols.net!master.news.rcn.net!not-for-mail From: Mike Chipperfield Newsgroups: bionet.genome.chromosomes,bionet.general Subject: Re: Molecular Biology Shortcuts Date: Wed, 24 Feb 1999 13:17:25 -0500 Lines: 28 Message-ID: <36D44235.1AF3@t3software.com> References: <36BA1DC8.A7C7ADA3@pariswater.com> Reply-To: mchipperfield@t3software.com Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Trace: nYCHtVxtWRwer1sBqTY//pMmoZKR+Ul0qlS5/GQ/zgdxYV1D7YsYOA== X-Complaints-To: abuse@rcn.com NNTP-Posting-Date: 24 Feb 1999 18:15:25 GMT Cc: cporter@gdb.org, cct@gdb.org X-Mailer: Mozilla 3.04 (WinNT; U) Xref: biosci bionet.genome.chromosomes:2312 bionet.general:32502 Centrale d'Annonces On-line wrote: > > Hello > > I would like to invite everybody to discover the new MBS - Molecular > Biology Shortcuts. > Try it at: > http://www.pariswater.com/biomol > > I created the site thinking in a molecular biology entry door to the > web. The main idea was that it is sometimes hard to avoid loosing too > much time on an internet search for some molecular biology tool. > Of course the project is not over. I would be very happy if you could > contribute with links, methods and protocols (tips, etc) to any subject > on molecular biology > > Enjoy! > Pierre Rodrigues > MBS Pierre, I used the "Databases" link on your MBS site. It brings back a number of useful databases, but I know of one which has been omitted: the human Genome Database (http://gdbwww.gdb.org/). Michael Chipperfield (formerly of GDB) From owner-chromosomes@net.bio.net Tue Feb 23 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Centrale d'Annonces On-line" Newsgroups: bionet.immunology,bionet.genome.chromosomes,bionet.drosophila,bionet.cellbiol,bionet.general,bionet.microbiology,bionet.glycosci,bionet.molbio.ageing,bionet.molbio.hiv,bionet.molbio.methds-reagnts,bionet.molbio.proteins Subject: Molecular Biology Shortcuts Date: 24 Feb 1999 08:27:32 -0800 Organization: Institut Pasteur, Paris Lines: 19 Sender: daemon@net.bio.net Distribution: world Message-ID: <36BA1DC8.A7C7ADA3@pariswater.com> Reply-To: mast62@pariswater.com NNTP-Posting-Host: net.bio.net Xref: biosci bionet.immunology:15785 bionet.genome.chromosomes:2310 bionet.drosophila:5019 bionet.cellbiol:11363 bionet.general:32501 bionet.microbiology:15921 bionet.glycosci:1711 bionet.molbio.ageing:4860 bionet.molbio.hiv:5373 bionet.molbio.methds-reagnts:74290 bionet.molbio.proteins:14002 Hello I would like to invite everybody to discover the new MBS - Molecular Biology Shortcuts. Try it at: http://www.pariswater.com/biomol I created the site thinking in a molecular biology entry door to the web. The main idea was that it is sometimes hard to avoid loosing too much time on an internet search for some molecular biology tool. Of course the project is not over. I would be very happy if you could contribute with links, methods and protocols (tips, etc) to any subject on molecular biology Enjoy! Pierre Rodrigues MBS From owner-chromosomes@net.bio.net Wed Feb 24 22:00:00 1999 Path: biosci!NETSGO.COM!airhead From: airhead@NETSGO.COM ("=?euc-kr?B?x+PDorW1?=") Newsgroups: bionet.genome.chromosomes Subject: www.biostudy.net/Q&A Date: 24 Feb 1999 18:49:58 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 31 Sender: daemon@net.bio.net Distribution: world Message-ID: <000701be6068$8e7d6380$874e73d2@1> Reply-To: "=?euc-kr?B?x+PDorW1?=" NNTP-Posting-Host: net.bio.net This is a multi-part message in MIME format. ------=_NextPart_000_0004_01BE60B3.FC65E020 Content-Type: text/plain; charset="euc-kr" Content-Transfer-Encoding: base64 UGxlYXNlIHZpc2l0IGhlcmUgYW5kIGxpbmsgeW91ciBwZXJzb25hbCBvciBsYWIgc2l0ZQ0KdGhl biBkaXNjdXNzaW9uIHJhcGlkbHkgYW5kIGVhc2lseSAuDQogDQpodHRwOi8vd3d3LmJpb3N0dWR5 Lm5ldC9RJkENCg== ------=_NextPart_000_0004_01BE60B3.FC65E020 Content-Type: text/html; charset="euc-kr" Content-Transfer-Encoding: base64 PCFET0NUWVBFIEhUTUwgUFVCTElDICItLy9XM0MvL0RURCBXMyBIVE1MLy9FTiI+DQo8SFRNTD4N CjxIRUFEPg0KDQo8TUVUQSBjb250ZW50PSJ0ZXh0L2h0bWw7IGNoYXJzZXQ9a3NfY181NjAxLTE5 ODciIGh0dHAtZXF1aXY9Q29udGVudC1UeXBlPg0KPE1FVEEgY29udGVudD0nIk1TSFRNTCA0Ljcy LjMxMTAuNyInIG5hbWU9R0VORVJBVE9SPg0KPC9IRUFEPg0KPEJPRFkgYmdDb2xvcj0jZmZmZmZm Pg0KPERJVj4NCjxESVY+PEZPTlQgY29sb3I9IzAwMDAwMCBzaXplPTI+UGxlYXNlIHZpc2l0IGhl cmUgYW5kIGxpbmsgeW91ciBwZXJzb25hbCBvciBsYWIgDQpzaXRlPC9GT05UPjwvRElWPg0KPERJ Vj48Rk9OVCBjb2xvcj0jMDAwMDAwIHNpemU9Mj50aGVuIGRpc2N1c3Npb24gcmFwaWRseSBhbmQg ZWFzaWx5IA0KLjwvRk9OVD48L0RJVj4NCjxESVY+PEZPTlQgY29sb3I9IzAwMDAwMCBzaXplPTI+ PC9GT05UPiZuYnNwOzwvRElWPg0KPERJVj48Rk9OVCBjb2xvcj0jMDAwMDAwIHNpemU9Mj48QSAN CmhyZWY9Imh0dHA6Ly93d3cuYmlvc3R1ZHkubmV0L1EmQSI+aHR0cDovL3d3dy5iaW9zdHVkeS5u ZXQvUSZhbXA7QTwvQT48L0ZPTlQ+PC9ESVY+PC9ESVY+PC9CT0RZPjwvSFRNTD4NCg== ------=_NextPart_000_0004_01BE60B3.FC65E020-- From owner-chromosomes@net.bio.net Wed Feb 24 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.stanford.edu!news-feed.inet.tele.dk!bofh.vszbr.cz!news.belnet.be!news.rediris.es!news.uva.es!not-for-mail From: Rosa M Corrales Herran Newsgroups: bionet.genome.chromosomes Subject: Re: Hey PLEASE SOMEBODY ANWSER THIS!!! Date: Thu, 25 Feb 1999 10:47:47 +0100 Organization: Universidad de Valladolid - Spain Lines: 10 Message-ID: <36D51C43.4D906A96@ioba.med.uva.es> References: <19990222185449.02887.00001811@ng-fx1.aol.com> NNTP-Posting-Host: med234.med.uva.es Mime-Version: 1.0 Content-Type: text/plain; charset=iso-8859-1 Content-Transfer-Encoding: 8bit X-Mailer: Mozilla 4.03 [es] (Win95; I) Brookie624 escribió: > > ok I need to know the anwser to this.. > IN X AND Y CHROMOSOMES WHICH IS THE MALE AND WHICH IS THE FEMALE...??? > > Thanx, > Brooke > P.S. Please anwser I am confused X is the female From owner-chromosomes@net.bio.net Wed Feb 24 22:00:00 1999 Path: biosci!UCRAC1.UCR.EDU!judelson From: judelson@UCRAC1.UCR.EDU ("Howard S. Judelson") Newsgroups: bionet.genome.chromosomes Subject: Postdoc positions, Phytophthora ESTs and functional genomics, Riverside CA USA Date: 25 Feb 1999 13:22:00 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 53 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net POSTDOCTORAL POSITIONS AVAILABLE Functional genomics/molecular genetics of Phytophthora infestans Postdoctoral associates are sought to study Phytophthora infestans, the oomycete fungus that causes the late blight diseases of potato and tomato. P. infestans is one of the world's most important plant pathogens, with a direct economic impact exceeding $5 billion per year. The successful applicants will join projects aimed at identifying and characterizing genes important in the growth and development of P. infestans, with an emphasis on sexual and asexual sporulation. The projects involve constructing cDNA libraries; identifying genes of interest from an EST catalogue and an expression profiling database (for example, microarrays); and characterizing the regulation and function of genes by manipulating their expression in P. infestans transformants and other strategies. Funding for these positions are available for up to 3 years. The laboratory is located at the Riverside campus of the University of California, which is situated in a dynamic region of southern California. Additional information about the laboratory is available at http://cnas.ucr.edu/~ppath/faculty/hj.html. Applicants must have a Ph.D. in a relevant discipline and demonstrated skill in cDNA library construction and/or gene analysis techniques. A good command of written and spoken English is required. Experience with filamentous fungi is NOT required and scientists with training in other systems (plants, etc.) are encouraged to apply. To apply, send a curriculum vitae and the names of three references (including addresses and telephone numbers) to the addresses shown below. Please label any email attachments with the author's last name! Dr. Howard Judelson Department of Plant Pathology University of California Riverside, California 92521 USA email: judelson@ucrac1.ucr.edu fax: 909-787-4294 Howard Judelson (judelson@ucrac1.ucr.edu) Associate Professor Department of Plant Pathology University of California Riverside, California 92521 USA Tel: 909-787-4199 Fax: 909-787-4294 From owner-chromosomes@net.bio.net Wed Feb 24 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!diablo.theplanet.net!news.theplanet.net!newspost.theplanet.net!not-for-mail From: "P L WARREN" Newsgroups: bionet.genome.chromosomes Subject: Chromosome 22q Date: Thu, 25 Feb 1999 22:23:14 -0000 Organization: Customer of Planet Online Lines: 6 Message-ID: <7b4ics$mam$1@news6.svr.pol.co.uk> NNTP-Posting-Host: modem-102.indium.dialup.pol.co.uk X-Trace: news6.svr.pol.co.uk 919981276 22870 62.136.24.102 (25 Feb 1999 22:21:16 GMT) NNTP-Posting-Date: 25 Feb 1999 22:21:16 GMT X-Complaints-To: abuse@theplanet.net X-Newsreader: Microsoft Outlook Express 4.72.3110.1 X-MimeOLE: Produced By Microsoft MimeOLE V4.72.3110.3 Our daughter was born 10 months ago with a deletion of chromosome 22q with a breakpoint at 13.2 does anybody have any information about this problem, The doctors are helpfull but not very informative. she at the moment is a healthy young girl but we as parents worry about her future. From owner-chromosomes@net.bio.net Fri Feb 26 22:00:00 1999 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.genome.chromosomes Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 27 Feb 1999 02:00:13 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 233 Sender: daemon@net.bio.net Distribution: world Message-ID: <199902271000.CAA06263@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-chromosomes@net.bio.net Fri Feb 26 22:00:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!news.maxwell.syr.edu!cpk-news-hub1.bbnplanet.com!news.gtei.net!firehose.mindspring.com!not-for-mail From: Jim Newsgroups: bionet.genome.chromosomes Subject: Re: Hey PLEASE SOMEBODY ANWSER THIS!!! Date: Sat, 27 Feb 1999 11:28:53 -0500 Organization: MindSpring Enterprises Lines: 21 Message-ID: <36D81D45.B5D8E5A8@Mindspring.com> References: <19990222185449.02887.00001811@ng-fx1.aol.com> NNTP-Posting-Host: a5.f7.8c.9f Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Server-Date: 27 Feb 1999 16:36:39 GMT X-Mailer: Mozilla 4.5 [en] (Win95; I) X-Accept-Language: en Brookie624 wrote: > ok I need to know the anwser to this.. > IN X AND Y CHROMOSOMES WHICH IS THE MALE AND WHICH IS THE FEMALE...??? > > Thanx, > Brooke > P.S. Please anwser I am confused It depends on the species! In humans, XX is a normal female and XY is a normal male, so the "Y" is the "male" chromosome. (That is, of course, a simplification!) For other species, the males have two sex chromosomes of the same type and it is the female that has one different (birds, for example). JDBarron@Mindspring.com From owner-chromosomes@net.bio.net Fri Feb 26 22:00:00 1999 Path: biosci!agate!newsfeed.berkeley.edu!newsfeed.cwix.com!4.1.16.34!cpk-news-hub1.bbnplanet.com!news.gtei.net!firehose.mindspring.com!not-for-mail From: Jim Newsgroups: bionet.genome.chromosomes Subject: Differences between H63D and C282Y HFE mutations (iron regulation) Date: Sat, 27 Feb 1999 11:30:32 -0500 Organization: MindSpring Enterprises Lines: 93 Message-ID: <36D81DA8.E51BDC74@Mindspring.com> NNTP-Posting-Host: a5.f7.8c.9f Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Server-Date: 27 Feb 1999 16:38:19 GMT X-Mailer: Mozilla 4.5 [en] (Win95; I) X-Accept-Language: en The H63D and C282Y HFE mutations are the two know mutations causing iron overload in humans (due to a dysfunction in iron regulations - specifically, a failure to down regulate the uptake of iron even when excess iron is already present.) I am a member of a web support group for patients with this disorder. It seems apparent from many postings on our list that the clinical presentation of those with one or two H63D alleles is very different than than of the far more common homozygous state for the C282Y mutation. The major difference appears to be that iron accumulates and causes damage in tissues other than the liver even *before* excess levels have begun to accumulate in the liver. (with the C282Y alleles, iron does not begin to accumulate in other tissues until a large excess has accumulated in the liver.) I feel that this difference has been missed clinically for the following reasons: Until very recently (i.e. the location of the gene involved) it was not possible to distinguish between the two mutations. Because the H63D allele is now known to have a much lower frequency than the C282 mutation, the clinical experience of iron overload and the development of diagnostic standards and therapy was based almost entirely on observation of patients homozygous for the C282Y mutation. (Any differences in lab values, clinical presentation, etc. in the H63D patients would have almost certainly be attributed to supposed co-existing unidentified medical problems (because of the rarity of such differences). Since there would also, of course, be a number of other coexisting medical conditions in many patients, any consistent pattern of differences in H63D patients would be unlikely to be noted due to the confounding effect of other conditions. In addition, if, as now seems to be the case, symptoms and problems occur in H63D patients at much lower levels of iron accumulation (and possibly even with no accumulation at all) H63D patients would be much less likely to be even diagnosed as having a disorder of iron regulation and thereby not even be considered in the same group as C282Y patients. (Unless serum ferritin, for example, is very elevated, iron dysregulation is unlikely to be even considered as a possible diagnosis. Yet some H63D patients experience major problems even at low levels of ferritin.) I think that the probable structural differences between the effects of the H63D and the C282Y mutations give good reasons for suspecting that major differences between the effects of the two mutations would be likely: H63D replaces a histidine residue (basic) with an aspartate residue (acidic), the shape of the replacement is very different (a side chain vs a side ring), the replacement has only 2 pKa's whereas the original has 3, and the lost histidine tends to have strong enzymatic activity. But the C282Y mutation mainly has the effect of the loss of a disulfide bond - leading to loss of stability, with the possibility of partial functionality remaining. I have only part of a biochemistry course, so I might well be wrong about that. Does this seem reasonable? I would welcome any comments! Does anyone on this list know of significant differences between the regulatory effects of the H63D and the C282Y HFE mutations? (Please e-mail me direct as I will not have time to go through all the lists I am posting this on (as no single list seems to be highly appropriate I am sending it to groups that are as closely related as I can find.) Early resolution of this issue might make a profound difference in the health of many H63Ds for who current diagnosis and treatment seems to be clearly inadequate for whatever reason. Many thanks Jim Barron JDBarron@Mindspring.com (C282Y/C282Y) From owner-chromosomes@net.bio.net Sun Feb 28 22:00:00 1999 Path: biosci!news.stanford.edu!newsfeed.berkeley.edu!news.maxwell.syr.edu!nntp.news.xara.net!xara.net!server5.netnews.ja.net!daresbury!not-for-mail From: ARGOS06@aol.com Newsgroups: bionet.genome.chromosomes Subject: SuperTips of Internet Marketing Date: 1 Mar 1999 09:23:30 -0000 Organization: Daresbury Laboratory, Warrington, U.K. Lines: 68 Message-ID: <7bdmai$dsi$1@mserv2.dl.ac.uk> NNTP-Posting-Host: mserv2.dl.ac.uk content-length: 2328 Return-Path: Apparently-To: Please do not forward this mail to my isp so I can get you off my list. If you foward this mail to my isp the remove list will go down and I will be unable to remove you. Thank you for your help. If you are a washington or a CA resident please remove yourself from my list. I appologize for this email. To be removed once and for all: Click Here. ---------------------------------------------------------------------- SuperTips of Internet Marketing Whether you are a beginner or an experienced Netrepreneur. . . this site will provide you with a wealth of Free information, Great ideas, Valuable tips to help you profit from the Internet. 1) How to Advertise and Market on the Net 2) How to Set up and Promote your Web Site 3) How to make Money on the Internet 4) How to become an Expert marketeer 5) How to attract Thousands of customers Our guides will show you how to write great ads , where to place your ads, how to win thousands of customers, and much more. We advise you how to choose the essential tools and services needed for online marketing, and how to let the world know about your web site. We reveal (1) the top selling items in the Internet and (2) the ideal type of Internet business. We then combine the results to bring you our top recommended opportunities. 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Smith From owner-chromosomes@net.bio.net Sun Feb 28 22:00:00 1999 Path: biosci!CORNELL.EDU!eev1 From: eev1@CORNELL.EDU (Elaine Van Etten) Newsgroups: bionet.genome.chromosomes Subject: Faculty Position Available Date: 1 Mar 1999 11:36:40 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 82 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net PalatinoMOLECULAR BIODIVERSITY OF PLANTS The Boyce Thompson Institute for Plant Research at Cornell University invites applications for a tenure-track position for a junior level scientist who uses genomics or proteomics approaches to study fundamental mechanisms underlying plant biodiversity at the organismal or population levels. Research areas of interest include, but are not limited to: - Adaptation to biotic or abiotic stresses or environmental factors - Genetics and biochemistry of plant-insect or plant-pathogen interactions - Molecular analysis of ecological systems The successful candidate will establish an independent, extramurally-funded research program and collaborate with colleagues at the Boyce Thompson Institute and elsewhere on the Cornell University campus. This position is synergistic with the Cornell Genomics Initiative which is a comprehensive effort to recruit 20 new genomics faculty to the Cornell campus and significantly upgrade facilities and infrastructure for genomics and proteomics research. Excellent start-up funds and benefits are available. Review of applications will begin April 5, 1999 and continue until the position is filled. Applicants should send a curriculum vitae, statement of research interests, and names of at least three references to Molecular Biodiversity Search Committee, Boyce Thompson Institute, Ithaca, New York 14853. Questions regarding the position may be directed to Dr. David Stern, 607-254-1306; e-mail ds28@cornell.edu or Dr. Robert Kohut, 607-254-1233, e-mail rjk9@cornell.edu. Boyce Thompson Institute is a private, independent, non-profit research institute formally affiliated with Cornell University. The institute is an affirmative action, equal opportunity employer and is committed to increasing the diversity of its faculty and staff. Applications from women and minorities are encouraged. From owner-chromosomes@net.bio.net Sun Feb 28 22:00:00 1999 Path: biosci!CORNELL.EDU!eev1 From: eev1@CORNELL.EDU (Elaine Van Etten) Newsgroups: bionet.genome.chromosomes Subject: Faculty Position Available Date: 1 Mar 1999 12:14:55 -0800 Organization: Cornell University Lines: 38 Sender: daemon@net.bio.net Distribution: world Message-ID: <36DAF4D2.6D20@cornell.edu> Reply-To: eev1@cornell.edu NNTP-Posting-Host: net.bio.net Faculty Position: MOLECULAR BIODIVERSITY OF PLANTS The Boyce Thompson Institute for Plant Research at Cornell University invites applications for a tenure-track position for a junior level scientist who uses genomics or proteomics approaches to study fundamental mechanisms underlying plant biodiversity at the organismal or population levels. Research areas of interest include, but are not limited to: - Adaptation to biotic or abiotic stresses or environmental factors - Genetics and biochemistry of plant-insect or plant-pathogen interactions - Molecular analysis of ecological systems The successful candidate will establish an independent, extramurally-funded research program and collaborate with colleagues at the Boyce Thompson Institute and elsewhere on the Cornell University campus. This position is synergistic with the Cornell Genomics Initiative which is a comprehensive effort to recruit 20 new genomics faculty to the Cornell campus and significantly upgrade facilities and infrastructure for genomics and proteomics research. Excellent start-up funds and benefits are available. Review of applications will begin April 5, 1999 and continue until the position is filled. Applicants should send a curriculum vitae, statement of research interests, and names of at least three references to Molecular Biodiversity Search Committee, Boyce Thompson Institute, Ithaca, New York 14853. Questions regarding the position may be directed to Dr. David Stern, 607-254-1306; e-mail ds28@cornell.edu or Dr. Robert Kohut, 607-254-1233, e-mail rjk9@cornell.edu. Boyce Thompson Institute is a private, independent, non-profit research institute formally affiliated with Cornell University. The institute is an affirmative action, equal opportunity employer and is committed to increasing the diversity of its faculty and staff. Applications from women and minorities are encouraged.