From owner-gene-linkage@net.bio.net Thu May 06 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!zaphod.mps.ohio-state.edu!uunet.ca!geac!r-node!zooid!goid From: goid@zooid.guild.org (Will Steeves) Newsgroups: bionet.molbio.gene-linkage,bionet.molbio.genome-program Subject: URGENTLY Seeking Statistical Reference re: cuckolded 'fathers'. Summary: Looking for a reference on a study which conducted blood tests. Message-ID: <1993May7.112317.26261@zooid.guild.org> Date: 7 May 93 11:23:17 GMT Sender: Will Steeves Organization: The Zoo of Ids Lines: 49 Xref: biosci bionet.molbio.gene-linkage:183 bionet.molbio.genome-program:468 Note: I wasn't sure which newsgroups was/were more appropriate for this. X-To: ALL About a year ago, I was working together with a reproductive rights activist in the Toronto area. He discussed a study that had been conducted in a number of U.S. cities, on the incidence of liver diseases in families (conceivably with a view to determining how much of a genetic link exists, if any, though he did not specifically state that this was the intent of the study). The study involved taking blood samples from mothers, fathers, and children, and conducting some sort of analysis (what kind, I don't know). However, here is the real shocker - although the researchers were not looking for this, they discovered that 18-30% (different cities had different results) of the family samples had children with blood types which were so incompatible with the "father"'s sample as to firmly disprove paternity. I recently mentioned this to a researcher (though I do not think that he would object to my mentioning his name, I did not formally seek permission, hence I will not give his name out), whose response was that the statistic seemed rather high. I'm inclined to believe it, except for one nagging statistic, ie., numerous studies of married couples reveal that 50% of husbands and 33% of wives have had affairs. Thus, if one grants that, _ceteris paribus_, there is an equal chance of pregnancy through sexual relations within the marriage as without (again, this presumes that either she is using the same type of protection in both cases, which includes no protection at all), this figure might _not_ be high after all (of course, one could always argue that the chance of the wife seeking an abortion secretly, MAY be higher if the pregnancy resulted from n affair, but then again, the 2-4 week post-abortion celibacy period might also alert the husband to the fact that she had had an operation, which would also cause suspicion ; hence, extramarital pregnancies may not be any more likely to be selected out by abortion). At any rate, logical posturing aside, I am curious as to whether anyone has heard about the above study. And if anyone has, does he/she have a journal reference of some sort? I have made numerous requests before, and while I could simply ask the person who informed me about the study, I have been unable to contact him. Any help would be *greatly* appreciated. --- Will Steeves, B.Sc. (Toronto), goid@zooid.guild.org "Neil Hull is GOiD" ZOOiD BBS, Toronto, Ontario - The Zoo Of Ids "GOiDS Rule" (416) 322-7876 "If possession is nine-tenths of the law, what's the other one-tenth?" - Will Steeves, President, GOiDS "R" We, Inc. * SLMR 2.1a * Use Orbital Mind Control Lasers, For a Better Tomorrow. From owner-gene-linkage@net.bio.net Fri May 07 23:00:00 1993 Path: biosci!daresbury!doc.ic.ac.uk!agate!ames!saimiri.primate.wisc.edu!usenet.coe.montana.edu!netnews.nwnet.net!news.u.washington.edu!max.u.washington.edu!wijsman From: wijsman@max.u.washington.edu Newsgroups: bionet.molbio.gene-linkage Subject: Re: URGENTLY Seeking Statistical Reference Message-ID: <1993May7.233329.1@max.u.washington.edu> Date: 8 May 93 07:33:29 GMT Lines: 53 NNTP-Posting-Host: max.u.washington.edu (stuff deleted) > The study involved taking blood samples from mothers, fathers, and > children, and conducting some sort of analysis (what kind, I don't know). > However, here is the real shocker - although the researchers were not > looking for this, they discovered that 18-30% (different cities had > different results) of the family samples had children with blood types > which were so incompatible with the "father"'s sample as to firmly > disprove paternity. > I recently mentioned this to a researcher (though I do not think that he > would object to my mentioning his name, I did not formally seek permission, > hence I will not give his name out), whose response was that the statistic > seemed rather high. (stuff deleted) > At any rate, logical posturing aside, I am curious as to whether anyone has > heard about the above study. And if anyone has, does he/she have a journal > reference of some sort? I have made numerous requests before, and while I > could simply ask the person who informed me about the study, I have been > unable to contact him. > Any help would be *greatly* appreciated. I don't have a reference immediately at hand which addresses the issue of the nonpaternity rate. However, I have been working with the analysis end of human pedigrees for many years, and I can say that the nonpaternity rate is much higher than the average person would believe. For example, I have recently made a first pass at doing paternity testing on 22 pedigrees which we have collected for a particular study, and of these, 4 had an identifiable non-paternity. (I insist on doing nonpaternity testing since for many genetic studies, unidentified nonpaternity has highly deleterious effects on the results of the analysis). These aren't huge pedigrees - size 5-10 individuals in 2-3 generations. One of these pedigrees had at least 3 different males involved in creating 5 children with one mother! It is important to note, however, that the non-paternity rate per offspring and the identifiable fraction of nuclear families with at least one nonpaternity are not the same thing. The detectable nonpaternity rate is now much higher than it used to be. The older blood group markers are inefficient for detecting nonpaternity because they have few alleles. The range of possible nonpaternity rates you cite is outside of the detectable range with blood group markers, but might be a plausible rate for highly polymorphic DNA markers. Ellen Wijsman Div of Medical Genetics, RG-25 and Dept of Biostatistics University of Washington Seattle, WA 98195 wijsman@u.washington.edu (206) 543-8987 From owner-gene-linkage@net.bio.net Tue May 11 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!torn!nott!uotcsi2!news From: alex@mgcheo.med.uottawa.ca (Dr. Alexander MacKenzie) Newsgroups: bionet.molbio.gene-linkage Subject: multipoint linkage question Message-ID: <1993May12.210013.6537@csi.uottawa.ca> Date: 12 May 93 21:00:13 GMT Sender: news@csi.uottawa.ca Organization: Dept. of Computer Science, University of Ottawa Lines: 6 Nntp-Posting-Host: mgcheo.med.uottawa.ca X-Newsreader: TIN [version 1.1 PL8] Is anyone aware of a program into which one can input linkmap data to generate numbers for a standard multipoint likliehood figure thanks Alex@mgcheo.med.uottawa.ca s From owner-gene-linkage@net.bio.net Fri May 21 23:00:00 1993 Path: biosci!uwm.edu!zaphod.mps.ohio-state.edu!howland.reston.ans.net!torn!csd.unb.ca!news.ucs.mun.ca!kean.ucs.mun.ca!roger From: roger@kean.ucs.mun.ca Newsgroups: bionet.molbio.gene-linkage Subject: LINKAGE under OS/2 operating system. Message-ID: <1993May22.115847.1@kean.ucs.mun.ca> Date: 22 May 93 15:28:47 GMT Sender: usenet@news.ucs.mun.ca (NNTP server account) Organization: Memorial University. St.John's Nfld, Canada Lines: 19 I have a couple of questions about running LINKAGE under OS/2. 1. What is the maximum number of haplotypes that can be handled (i.e. what is the maximum, if any, for the MAXHAP constant)? 2. Am I correct in assuming that I must accquire a Prospero Pascal or NDP Pascal compiler before I can tinker with the values for the constants and what is the cost of these compilers? 3. Is the full version of the NDP compiler available now and what is the address/phone number for NDP? I am interested in multipoint analysis with microsatellite markers, hence the need for a big MAXHAP and OS/2. Any other suggestions or advice would be welcome. Roger C. Green, Faculty of Medicine Phone: (709)737-6884 Memorial University , St. John's, Newfoundland. FAX : (709)737-7010 From owner-gene-linkage@net.bio.net Fri May 28 23:00:00 1993 Path: biosci!uwm.edu!ux1.cso.uiuc.edu!howland.reston.ans.net!darwin.sura.net!news.udel.edu!chopin.udel.edu!daschaff From: daschaff@chopin.udel.edu (Dennis A Schaff) Newsgroups: bionet.molbio.gene-linkage,bionet.molbio.gen-org,bionet.molbio.genome-program,bionet.molbio.proteins Subject: Call for Abstracts MAPMBS meeting Message-ID: Date: 29 May 93 14:14:33 GMT Sender: usenet@news.udel.edu Organization: University of Delaware Lines: 241 Xref: biosci bionet.molbio.gene-linkage:187 bionet.molbio.genome-program:483 bionet.molbio.proteins:675 Nntp-Posting-Host: chopin.udel.edu Call for Abstracts 10th Annual Meeting Mid-Atlantic Plant Molecular Biology Society July 15-16, 1993 University of Delaware, Clayton Hall Newark, Delaware Please return Registration and Abstracts by June 25, 1993. Keynote Address Sheila McCormick, USDA/ARS--Plant Gene Expression Center Molecular analysis of gametogenesis in plants. Gene Regulation Becky Boston--North Carolina State University--Regulation and function of maize ribosome inactivating proteins. Michael Dobres--Drexel University--A transcriptional marker for epidermal differentiation in Pisum sativum. Carroll Vance--USDA/ARS, University of Minnesota--Primary assimilation of nitrogen in alfalfa nodules: Molecular features of the enzymes involved. John Watson--University of Maryland--Photo-regulated expression of protein kinase genes. Plant/Microbe Interactions Jim Carrington--Texas A&M--Replication and movement of a potyvirus that expresses GUS. Dan Roberts--USDA/ARS, Beltsville--Molecular basis of rhizosphere colonization by the plant beneficial bacterium, Enterobacter cloacae. Barbara Valent--Du Pont Co.--Two cloned genes for host specificity in the rice blast fungus, Magnaporthe grisea. Transformation/Techniques Ted Klein--Du Pont Co.--Maize transformation: An industrial perspective. Antoni Rafalski--Du Pont Co.--Technology for molecular breeding: RAPD markers, microsatellites, and machines. Developing Technologies Paul Gilna--Los Alamos--The latest advances in community-based access to sequence data submission and maintenance technologies for GenBank. Post-meeting Tour Friday evening, July 16, 1993. We are planning a tour of Longwood Gardens, Kennett Square, PA (18 miles from the University of Delaware). Tenth Annual Meeting of the Mid-Atlantic Plant Molecular Biology Society Univerity of Delaware, Newark, DE July 15-16, 1993 Registration due by June 25, 1993 The Mid-Atlantic Plant Molecular Biology Society (MAPMBS) was formed to provide a high quality, accessible, and affordable plant molecular biology meeting each year for scientists in the Mid-Atlantic region. The society wishes especially to encourage presentations by postdoctoral fellows and graduate students. Toward this goal, and as a special incentive, the registration fee for students who are presenting short talks or posters (one presenter per abstract please) includes only the cost of food and beverages. This year's keynote address on Thursday July 15 will be given by Dr. Sheila McCormick, USDA, ARS, Plant Gene Expression Center, Albany, CA. Dr. McCormick's lecture will be followed by an informal social hour and dinner. Registration for the conference will open at 8:00 a.m. on Thursday inside Clayton Hall. Talks will begin promptly at 9:00 a.m. Thursday and 8:00 a.m. Friday. Two platform sessions will be held each day. Each platform session consists of two or three 30-minute talks by invited speakers followed by short contributed talks of approximately 15-20 minutes. Poster presentations are also encouraged. Time will be reserved for poster presentation and discussion. To present either a talk or a poster please submit an abstract (see directions for format). If you prefer to give a talk, please indicate the session you feel would be most appropriate. Accommodations for participants requiring overnight lodging can be made at the University of Delaware on-campus housing. A block of rooms has been reserved for participants. Arrangements must be made by participants through the Conference Center at Clayton Hall (housing form enclosed). Lodging will be available for Wednesday and Thursday nights at the conference rate (additional nights may be arranged on an individual basis). Breakfast can be bought at the Cafeteria (breakfast $4.50). If you prefer other accommodations, please make your own arrangements. Pre-registration is strongly encouraged. Please note that this is the only announcement and call for abstracts that will be mailed. For those who register in advance, lunches and dinner will be provided and are included in the pre-registration fees. Ample parking is available in the Conference Center parking lot. Walk-in registration will also be available at the door on Thursday morning July 15. ABSTRACT FORMAT (Abstracts are photocopied without modification) TITLE IN CAPITAL LETTERS: Author(s) Name; Author(s) Affiliation, and Address. Please type your abstract on 8.5" x 11" white paper leaving a 1.5" margin on all sides. Mail the original abstract and one copy to the address listed on the registration form. Be sure to check the appropriate spaces on the registration form to indicate your preference for presentation format (short talk or poster) and session. You will be notified of the session, time, and format for your presentation. Posters should fit within a 4' x 4' area. Please return your abstract by June 25, 1993. Your attendance and participation are essential to the continued growth and productivity of the MAPMBS. We look forward to meeting you in July! For further information, contact: Send Abstracts to: Dennis A. Schaff Ben Matthews Department of Plant and Soil Sciences MAPMBS University of Delaware c/o USDA-ARS, PMBL Newark, Delaware 19717-1303 B-006, BARC-West Phone: (302) 831-2534 10300 Baltimore Avenue FAX: (302) 831-3651 Beltsville, MD 20705-2350 E-mail: daschaff@brahms.udel.edu Registration Form Please return by June 25, 1993 Please photocopy this page and mail the registration and housing forms SEPARATELY; MAPMBS will not guarantee forwarding of housing forms sent to Beltsville. Name _________________________________ I am interested in presenting: Institution __________________________ _____ A short talk Department __________________________ _____ A poster Address ______________________________ (Be sure abstract is enclosed) City ________________________________ State ________________________________ Platform session preference: Zip Code _____________________________ _____ Gene Regulation Telephone ____________________________ _____ Plant/Microbe Interactions FAX __________________________________ _____ Transformation/Techniques E-mail _______________________________ Pre-registration: Late registration (after June 25): Presenting Student.......... $50 N/A Student..................... $65 $75 Regular registration........ $80 $90 Total amount enclosed....... $_______ Make Checks Payable to MAPMBS Pre-registration includes meeting attendance, 2 lunches, social hour, and Thursday banquet. ______ Please check if interested in the post-meeting tour to Longwood Gardens (Friday July 16). ______ Special dietary requirements. Please specify:_____________________ Choice of meals for banquet (check one) ______ Chinese Flank Steak ______ Vegetarian Platter ______ Delaware Combo (Crabcake and Chicken Breast ) Mail Registration Materials to: Ben Matthews MAPMBS Meeting c/o USDA-ARS, PMBL B-006, BARC-West 10300 Baltimore Avenue Beltsville, MD 20705-2350 Housing Reservation Form 10th Annual Meeting: Mid-Atlantic Plant Molecular Biology Society July 15-16, 1993 Name_________________________________ Title/position____________________ Affiliation_____________________________________________________________ Address_________________________________________________________________ City____________________________________State__________Zip______________ Telephone Numbers (work)_________________ (home)_______________________ Housing Christiana Towers Apartments (dormitory) All bedrooms have single/twin beds. Rooms do not have television, radio, or clock. [ ] 1 bedroom, 1 person . . . $30.75 per person per night. [ ] 1 bedroom, 2 people . . . $16.75 per person per night. [ ] 2 bedrooms, 2 people . . $18.00 per person per night. [ ] 2 bedrooms, 3 people . . $13.50 per person per night. [ ] 2 bedrooms, 4 people . . $11.00 per person per night. If you want to share a bedroom with a particular person(s), please indicate name(s). Roommate preference, if any _____________________________________________ If you wish to share a bedroom with any MAPMBS participant, circle your sex (M) or (F). If you select other than single accommodations and do not indicate a roommate preference, you may be assigned and charged a single room if no roommate is available. Arrival Date: ___________ Departure Date: _____________ ________ (nights) x $ ________ (rate). . . . . . . . . . . . . .$ _______ Linen Package (required) . . . . . . . . . . . . . . . . . . . .$ 9.95 Total Housing . . . . . . . . . . . . . . . . . . . . . . . . . $ _______ [ ] Enclosed is my check for $ ________ made payable to the "University of Delaware." [ ] Please charge $________ to my: ____MasterCard; ____VISA; ____Discover Card Number ___________________________ Expiration Date: ________________ Authorized Signature _____________________________________________ Note: If paying by credit card, you may FAX your reservation form to 302-831-2998. Sorry, we cannot accept your FAX if paying by check. Purchase Orders are accepted. Please return no later than July 6 to: Conferences and Centers Continuing Education University of Delaware Newark, DE 19716-7430 Phone: 302-831-2216