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From: atthew1@indiatimes.com
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Subject: Only 14 Good Reps Needed ...
Date: 1 Feb 2000 02:34:47 -0000
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---


From owner-molmodel@hgmp.mrc.ac.uk  Thu Feb  3 16:25:50 2000
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From: Shawn Strande <strande@sdsc.edu>
X-Newsgroups: bionet.molec-model
Subject: ISMB 2000: Final Call for Papers
Date: Thu, 03 Feb 2000 08:22:50 -0800
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--------------EA075B651FAEFCA90C115C94
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                          FINAL CALL FOR PAPERS

                 The Eighth International Conference on
           Intelligent Systems for Molecular Biology (ISMB 2000)
                       August 19 - August 23, 2000
                        San Diego, California USA
                         http://ismb2000.sdsc.edu

Submission deadlines are rapidly approaching for papers, posters, and
demonstrations for the upcoming Eighth International Conference on
Intelligent Systems for Molecular Biology (ISMB 2000), August 19-23, 2000,
UC San Diego, California USA. Essential information is given below, with
additional details available at: http://ismb2000.sdsc.edu.

We look forward to your participation to help make this a successful meeting.

Sincerely,

Phil Bourne & Michael Gribskov
Program Chairs, ISMB 2000

------------------------

Papers
------
Deadline for receipt: February 14, 2000
Papers should be a maximum of 12 pages, single-spaced, including title,
abstract, figures, tables, and bibliography. The first page should give
keywords, postal and electronic mailing addresses, telephone and fax
numbers.  Submit papers electronically to ismb2000@sdsc.edu in either 
postscript or pdf format. Papers will only be accepted electronically.  
Complete formatting details are available at:
http://www.aaai.org/Publications/Author/authorinstructions.html
PAPERS NOT CONFORMING TO THESE GUIDELINES WILL BE RETURNED WITHOUT REVIEW.

Tutorials
---------

Closed.

Posters and Software Demonstrations
-----------------------------------
Abstracts due: May 31, 2000
An abstract of your poster should be submitted by May 31, 2000, including
title, author(s), affiliation(s), e-mail address(es), text, and references.
Poster space will be approximately 145 cm (4 ft) high by 110 (3 ft) cm wide.
If you represent an academic group and wish to demonstrate software,
please notify the conference organizers by sending e-mail to 
ismb2000@sdsc.edu as soon as possible.

Key Dates
---------
Meeting:
Tutorial presentations: Aug 19, 2000
Paper presentations: Aug 20-23, 2000

Paper Submissions:
Papers must be received by: Feb 14, 2000
Replies to authors by: Mar 20, 2000
Revised papers must be received by: Apr 10, 2000

Open Poster Submissions
Abstracts must be received by: May 31, 2000

Tutorial Proposals

Closed.

Registration
Begins: Apr. 15, 2000 Ends: June 15, 2000

--------------EA075B651FAEFCA90C115C94--



From owner-molmodel@hgmp.mrc.ac.uk  Thu Feb  3 23:16:25 2000
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From: maria2323@laoffices.com
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Subject: TV De-scambler 4 under $17
Date: 3 Feb 2000 23:16:19 -0000
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CABLE TV DE-SCRAMBLER

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---


From owner-molmodel@hgmp.mrc.ac.uk  Tue Feb  8 14:44:18 2000
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From: Simon Hubbard <sjh@sjh.bi.umist.ac.uk>
X-Newsgroups: bionet.molec-model,bionet.jobs,bionet.jobs.offered,bionet.molbio.proteins,comp.jobs
Subject: UK PhD Position in Bioinformatics at UMIST, Manchester
Date: 8 Feb 2000 14:44:00 -0000
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UK PhD Position in Bioinformatics at UMIST, Manchester

NOVEL BIOINFORMATIC APPROACHES TO PROTEOME PROTEIN IDENTIFICATION

A 3 year BBSRC/EPSRC studentship in Bioinformatics is available
from October 2000 working in the group of Dr. Simon Hubbard at
UMIST, Manchester. The project will entail developing and extending
exisiting programs and tools for proteome protein identification from
mass spectrometric data. Novel data sources will be evaluated, including
non-denaturing digestions on proteins prior to analysis and the ability
to "jump-species" will be investigated. Results will be exploited in a 
new range of software for proteome protein identification. These will 
then be tested using exemplary systems where mass spectrometric data 
is already being collected here at UMIST. Examples include studies 
on the Chicken muscle proteome (Beynon group) and the protein 
phosphorylation in developmental pathways in leukaemic cell lines 
(Whetton group). The ability of the tools to routinely identify
likely protein matches will be assessed. 

For more details on the project, see http://sjh.bi.umist.ac.uk/~sjh
or email Simon.Hubbard@umist.ac.uk

Applicants should have a good first degree in a Science, which does
not necessarily contain a biological component. Applications
are particularly welcome from students with computational and/or
physical backgrounds. BBSRC/EPSRC studentships are only open to UK/EU
applicants.

-- 
____________________________________________________________________
Dr. Simon Hubbard                     TEL: +44 (0)161 200 8930 
Lecturer                              FAX: +44 (0)161 236 0409
Department of Biomolecular Sciences   mailto:sjh@sjh.bi.umist.ac.uk
UMIST, PO Box 88, Manchester M60 1QD  http://sjh.bi.umist.ac.uk/~sjh



From owner-molmodel@hgmp.mrc.ac.uk  Thu Feb 10 19:30:49 2000
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From: jschenkm@neuron.uchc.edu ("John B. Schenkman")
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Subject: Postdoctoral Position Available
Date: 10 Feb 2000 19:30:45 -0000
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Postdoctoral Position at the University of Connecticut
We are seeking a strongly motivated individual to aid in the investigation
of the role of cytochrome P450 in tissue development. Successful candidate
must have understanding of biochemistry, be familiar with protein
purification, and enzyme assays. Other useful techniques include
immunochemical analyses, GC/MS, and HPLC. The group has linked the disease
Primary Congenital Glaucoma to defects in the enzyme Cytochrome P450 1B1.
The planned study will attempt to discern the mechanism whereby defective
CYP1B1 results in formation of a defective trabecular meshwork in the
developing eye. Initial molecular modeling has revealed how structural
defect influence properties of the enzyme.

Send Curriculum vitae to: Dr. John B. Schenkman
                                          Department of Pharmacology
                                University of Connecticut Health Center
                                        Farmington, CT 06030, USA
                                   or:  jschenkm@neuron.uchc.edu

		***************************************************
		     Dr. John B. Schenkman, Professor
		     Department of Pharmacology
		     University of Connecticut Health Center
		     263 Farmington Ave.
		     Farmington, CT 06030
		     tel: (860) 679-3694
		     FAX (860) 679-2473
		     email: jschenkm@neuron.uchc.edu
		     My WebPage:http://p450.uchc.edu
		***************************************************
---


From owner-molmodel@hgmp.mrc.ac.uk  Fri Feb 11 01:06:48 2000
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From: szia@hanga.enzim.hu (Andras Szilagyi)
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Subject: E-mail address of Anthony Nicholls?
Date: 11 Feb 2000 01:06:46 GMT
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Hi,

does anybody know the current e-mail address of Anthony Nicholls, the
author of GRASP? GRASP is a software for coloring protein surfaces by
some properties, most often the electrostatic potential. Anthony Nicholls
used to be in Barry Honig's lab at Columbia University but he is
apparently not there any longer. If you know his current e-mail address
then please e-mail me.

Andras Szilagyi, PhD (szia@enzim.hu)
Institute of Enzymology, Hungarian Academy of Sciences
Karolina ut 29., H-1113 Budapest, HUNGARY
Fax: +36 1 466 5465, phone: +36 1 466 5633


From owner-molmodel@hgmp.mrc.ac.uk  Sat Feb 12 00:47:15 2000
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From: "Andrew C.R. Martin" <a.c.r.martin@reading.ac.uk>
X-Newsgroups: bionet.molec-model,comp.ai
Subject: CFP: AI in Bioinformatics Symposium
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        ******************************************************
        SYMPOSIUM ON ARTIFICIAL INTELLIGENCE IN BIOINFORMATICS
        ******************************************************


              This symposium will take place as part of:

                       Time for AI and Society

             2000 Convention of the Society for the Study
      of Artificial Intelligence and the Simulation of Behaviour
                              (AISB-00)

                       University of Birmingham
                               England

                   Convention: 17th-20th April 2000
                    Symposium: 19th-20th April 2000


This symposium intends to draw together those who are applying
artificial intelligence techniques to bioinformatics related
issues. Participants are keenly sought from both a lifesciences
background and a computer sciences background. The symposium will hope
to make a significant contribution to the computer scientists'
appreciation of the bioinformatics-related opportunities for the
techniques, and the life scientists' appreciation of the potential of
artificial intelligence methods.

The provisional list of speakers includes:
        Robert Burbidge (UCL)
        Thomas Dandekar (EMBL)
        David Gilbert (City)
        Kevin Humphreys (Sheffield)
        Richard M. Jackson (UCL)
        Steffen Moeller (EBI)
        Martin Reese (Berkeley)
        Marcel Turcotte (ICRF)


               !!! Poster presentations are welcome !!!


More information is available on the symposium is available from:
        http://www.rdg.ac.uk/~sas99acm/aisb00/
or on the convention as a whole:
        http://www.cs.bham.ac.uk/~mgl/aisb/
Registration information:
        http://www.cs.bham.ac.uk/~mgl/aisb/registration/


You may also contact the symposium organisers directly:

Andrew C.R. Martin (Animal & Microbial Sciences, University of Reading)
        a.c.r.martin@reading.ac.uk
David W. Corne (Computer Science, University of Reading)
        d.w.corne@reading.ac.uk


-- 
Dr. Andrew C.R. Martin          EMail:  a.c.r.martin@reading.ac.uk (work)
Lecturer in Bioinformatics              andrew@stagleys.demon.co.uk (home)
University of Reading
Tel.: +44 (0)118 987 5123x7022  Fax:    +44 (0)118 931 0180

[ comp.ai is moderated.  To submit, just post and be patient, or if ]
[ that fails mail your article to <comp-ai@moderators.isc.org>, and ]
[ ask your news administrator to fix the problems with your system. ]


From owner-molmodel@hgmp.mrc.ac.uk  Sat Feb 12 13:28:44 2000
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From: duo47@kurasc.kyoto-u.ac.jp (dan)
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Subject: Private Offshore Club Pays You by the Minute!
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From owner-molmodel@hgmp.mrc.ac.uk  Wed Feb 16 18:09:10 2000
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From: "Tatsuya Akutsu" <takutsu@ims.u-tokyo.ac.jp>
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Subject: RECOMB 2000: preliminary program and updates
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Dear colleague:

Enclosed is the preliminary program of RECOMB 2000.
We are looking forward to an exciting program, including
nine keynote presentations by distinguished scientists, 
36 contributed talks selected by the Program Committee, 
and 120 accepted posters.

Please note: the early registration deadline is February 20, 2000.
The deadline for hotel reservation is March 1, 2000.

The list of accepted posters, as well as resigration and hotel
information, is available at http://recomb2000.ims.u-tokyo.ac.jp.
Further updates will be posted on the website.

See you in Tokyo,

Ron Shamir
RECOMB 2000 Program Chair 

----------------------------------------------------------------


       FOURTH ANNUAL INTERNATIONAL CONFERENCE ON
             COMPUTATIONAL MOLECULAR BIOLOGY

                  (RECOMB 2000)

                 April 8-11, 2000
                   Tokyo, Japan

                   Organized by
    Human Genome Center, Institute of Medical Science,
        University of Tokyo

                     Sponsored by
    ACM (Association for Computing Machinery)  - SIGACT

                  with support from
    Agilent Laboratories
                       Compugen
                   IBM Corporation
      International Society for Computational Biology
                  SmithKline Beecham
             US National Science Foundation
                 US Department of Energy

             http://recomb2000.ims.u-tokyo.ac.jp 
 
  Preliminary Program
  -------------------


Friday April 7
***************
16-19 Welcome and  Registration
18:00 Reception

Saturday April 8
****************
9:00 opening remarks
   Ron Shamir, RECOMB 2000 Program Chair
   Satoru Miyano, RECOMB 2000 Organizing Committee Chair
   Thomas Lengauer, RECOMB 2001 Program Chair

9:15-10:15 The Stanislaw Ulam Computational Biology Address.
Minoru Kanehisa : 
Sequence Comparison to Graph Comparison-A New Generation
of Algorithms for Network Analysis of Interacting Molecules

10:20-10:45  S. Batzoglou, L. Pachter, J. P. Mesirov, B. Berger,
E. S. Lander: 
Comparative Analysis of Mouse and Human DNA and Applications to 
Exon Prediction

10:45-11:10  P. Pevzner, V. Dancik, C. L. Tang:
Mutation-Tolerant Protein Identification by Mass-Spectrometry

11:10-11:40    break

11:40-12:05   N. Friedman, M. Linial, I. Nachman, D. Pe'er:
Using Bayesian Networks to Analyze Expression Data

12:05-12:30  A. Ben-Dor, L. Bruhn, N. Friedman, I. Nachman, 
M. Schummer, Z. Yakhini:
Tissue classification with gene expression profiles

12:30-12:55  D. K. Slonim, P. Tamayo, J. P. Mesirov, T. R. Golub, 
E. S. Lander:
Class prediction and discovery using gene expression data

12:55-14:15    lunch (poster setup period)

14:15-15:15 Keynote Lecture: Hans Lehrach
A Data-Analysis Pipeline for Large-Scale Gene Expression Analysis

15:20-15:45    C. Bailey-Kellogg, A. Widge, J. J. Kelley, M. J. 
Berardi, J. H. Bushweller, B. R. Donald:
The NOESY Jigsaw: automated protein secondary structure and 
main-chain assignment from sparse, unassigned NMR data

15:45-16:10  J. M. Sorenson, T. Head-Gordon:
Matching simulation and experiment: a new simplified model for 
simulating protein folding

16:10-16:40    break

16:40-17:40 Keynote Lecture: Svante Paabo
DNA Sequence Variation among Humans and Apes

17:45-18:10   A. Zien, R. Zimmer, T. Lengauer:
A simple iterative approach to parameter optimization

18:20-20:00  business meeting



Sunday April 9
**************
9:00-10:00 Keynote Lecture: Eric Davidson
Computational Analyses of Developmental cis-Regulatory Control Systems

10:05-10:30    T. Akutsu, S. Miyano, S. Kuhara :
Algorithms for Identifying Boolean Networks and Related Biological
Networks Based on Matrix Multiplication and Fingerprint Function

10:30-10:55    M. Tomita, K. Hashimoto, K. Takahashi, Y. Matsuzaki, 
R. Matsushima, K. Yugi, F. Miyoshi, H. Nakano, Y. Saito, S. Shimizu, 
Y. Nakayama :
The E-CELL project: towards integrative simulation of cellular processes

10:55-11:25    break

11:25-11:50    A. Liwo, J. Pillardy, C. Czaplewski, J. Lee, D. R. 
Ripoll, M. Groth, S. Rodziewicz-Motowidlo, R. Kazmierkiewicz, R. J. 
Wawak, S. Oldziej,  H. A. Scheraga :
UNRES -- a united-residue force field for energy-based prediction 
of protein structure - origin and significance of multibody terms

11:50-12:15 Y. Z. Ohkubo, G. M. Crippen :
Determining Contact Energy Function for Continuous State Models of 
Globular Protein Conformations

12:15-15:00    poster session and lunch

15:00-16:00 Keynote Lecture: Takashi Gojobori
Evolutionary Features of Genomes as Disclosed by Comparative 
Analysis of Complete Genome Sequences

16:05-16:30    B. Chor, M. D. Hendy, B. R. Holland, D. Penny :
Multiple Maxima of Likelihood in Phylogenetic Trees: An Analytic 
Approach

16:30-16:55  R. Desper, M. Vingron :
Tree Fitting: an Algebraic Approach Using Profile Distances

16:55-17:25   break

17:25-17:50   D. Sankoff, D. Bryant, M. Deneault, B. F. Lang, G. Burger :
Early Eukaryote Evolution Based on Mitochondrial Gene Order Breakpoints

17:50-18:15   K. Chen, D. Durand, M. Farach-Colton :
Notung: Dating gene duplications using gene family trees

18:30-21:30 banquet and Distinguished Biology Lecture: Walter Gilbert
Introns and Modules in Ancient Conserved Genes



Monday April 10
***************
9:00-10:00 Distinguished New Technologies Lecture: Leroy Hood
Computing Life and Global Technologies

10:05-10:30    A. Ben-Dor, R. M. Karp, B. Schwikowski, Z. Yakhini :
Universal DNA tag systems: a combinatorial design scheme

10:30-10:55   F. P. Preparata, E. Upfal :
Sequencing-by-hybridization at the information-theory bound: an 
optimal algorithm

10:55-11:25   break

11:25-11:50    R. B. Lyngso, C. N. S. Pederson :
Pseudonknots in RNA Secondary Structures

11:50-12:15   Y. Xu, D. Xu, O. H. Crawford, J. R. Einstein, E. Serpersu :
Protein Structure Determination using Protein Threading and Sparse  
NMR Data

12:15-12:40   E. Althaus, O. Kohlbacher, H. P. Lenhof, P. Mueller :
A combinatorial approach to protein docking with flexible side-chains

12:40-14:00    lunch

14:00-15:00 Keynote Lecture: Yusuke Nakamura
Human Genome Analysis and Medicine in the 21st Century

15:05-15:30    R. Bundschuh :
An Analytic Approach to Significance Assessment in Local Sequence  
Alignment with Gaps

15:30-15:55   T. Akutsu, H. Arimura, S. Shimozono
On Approximation Algorithms for Local Multiple Alignment

15:55-16:25    break

16:25-16:50     M. Kann, R. A. Goldstein :
Optimizing for Success: A New Score Function For Distantly Related 
Protein Sequence Comparison

16:50-17:15   S. A. Teichmann, C. Chothia, G. M. Church, J. Park :
PDB-ISL: an intermediate sequence library for fast assignment of 
protein structures to sequences

17:15-17:40   J. R. Bienkowska, L. Yu, S. Zarakhovich, R. G. Rogers, 
T. F. Smith :
Comprehensive statistical method for protein fold recognition

17:40-19:40 poster session



Tuesday April 11
****************

9:00-10:00 Keynote Lecture: Yvonne Martin
Molecular Diversity: Strategies and Concerns

10:05-10:30     S. Heber, J. Stoye, J. Hoheisel, M. Vingron :
Contig Selection in Physical Mapping

10:30-10:55    J. Kececioglu, S. Shete, J. Arnold :
Reconstructing distances in physical maps of chromosomes with 
nonoverlapping probes

10:55-11:25    break

11:25-11:50    L. Marsan, M.-F. Sagot :
Extracting structured motifs using a suffix tree - Algorithms and 
application to promoter consensus identification

11:50-12:15   X. Chen, S. Kwong, M. Li :
A Compression Algorithm for DNA Sequences and Its Applications 
in Genome Comparison

12:15-12:40   R. Hart, A. K. Royyuru, G. Stolovitzky, A. Califano :
Systematic and Automated Discovery of Patterns in PROSITE Families

12:40-14:00    lunch

14:00-14:25  M. Linial, E. Portugaly :
Probabilities for having a new fold on the basis of a map of all 
protein sequences

14:25-14:50   G. Yona, M. Levitt :
A unified sequence-structure classification of protein sequences: 
combining sequence and structure in a map of the protein space

14:50-15:15   A. Apostolico, G. Bejerano :
Optimal Amnesic Probabilistic Automata or How to Learn and Classify 
Proteins in Linear Time and Space

15:15-15:45    break

15:45-16:35     S. Batzoglou, B. Berger, J. P. Mesirov, E. S. Lander :
Sequencing a Genome by Walking with Clone-end Sequences: A Mathematical 
Analysis

16:10-16:35   M. T. Hallett, J. Lagergren :
New Algorithms for the Duplication-Loss Model

16:35 End of Conference 

17:00    sightseeing tour: boat ride and dinner (optional)






From owner-molmodel@hgmp.mrc.ac.uk  Mon Feb 21 22:32:51 2000
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From owner-molmodel@hgmp.mrc.ac.uk  Wed Feb 23 08:32:59 2000
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From: "Gabor E. Tusnady" <tusi@enzim.hu>
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Dear Colleague,

I'm pleased to announce that the HMMTOP server has been updated. HMMTOP is
a transmembrane helices and topology prediction software, which is
available at the www site:

                      http://www.enzim.hu/hmmtop

The C source code of the software is now freely available. Please visit
the http://www.enzim.hu/hmmtop/doc/license.html for more information.
If you have any question or problem, feel free to e-mail me
(tusi@enzim.hu).

Gabor E. Tusnady, PhD                   | e-mail:            tusi@enzim.hu
Institute of Enzymology, BRC            | www:   http://www.enzim.hu/~tusi
Hungarian Academy of Sciences           | tel:         (36-1) 466-6533/158
H-1113 Budapest Karolina ut 29, HUNGARY | fax:             (36-1) 466-5465








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From: parntzen@mail.icav.up.pt ("Pim Arntzen")
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#

Some European urodeles have up to 10% of their genomes composed of a single class of satellite DNA.  The satellite is a 32/33 bp sized, tandemly repeated fragment and is supposedly non-functional.

DNA-sequence analysis shows four types of satellites (1, 2, 3 and 4). Their repeat sequence is distinctly non-random as 1414 etc. and 2323 etc. Other combinations (ie. 12, 13, 24 and 34) appear absent or rare.

Phylogenetic analysis at the level of the satellite shows that the types are ordered in an (unrooted) network as 1-2-3-4. Phylogenetic analysis at the species level indicates that the 14 character state is derived and the 23 character state is ancestral. Both the 14 and 23 'supertypes' are old (estimated age 2-5 and ca. 10 million years, respectively).

One particular feature that existing supertypes have in common is a combined size of 65 bp, with some further non-random association of nucleotide character states at nine positions (out of 29 - ignoring the HaeIII restriction site used to generate the fragments).

I am searching for a mechanistic explanation for the existence of the 14 and 23 supertypes as might be suggested from conserved sequence information. I would appreciate receiving suggestions how to approach this problem. As a classical taxonomist I am unfamiliar with (the software in) this field.

Pim Arntzen





###

J. W. (Pim) Arntzen
Universidade do Porto
Unidade de Genetica Animal e Conservacao
Campus Agrario de Vairao
Rua de Monte, Crasto, Vairao
4480 Vila do Conde
Portugal

### 


---


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From: zhou@tammy.harvard.edu (Yaoqi Zhou)
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Subject: Postdoc positions: Theoretical/Computational Biophysics, SUNY Buffalo
Date: 24 Feb 2000 18:46:55 -0000
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Postdoctoral positions are available after July 1, 2000 at Center for
Single Molecular Biophysics of Department of Physiology and Biophysics
of SUNY Buffalo to conduct theoretical and computational research in
biophysics. Qualified candidates should have a PhD in Chemistry,
Physics, or related field.  Experience with theoretical/computational
biophysics, statistical mechanics, and/or computer simulations is a
plus but not necessary.  However, strong mathematical and some
programming skills are essential. The main area of our interest is
protein folding and protein binding using statistical mechanics
theories and simulation methods (please visit
http://yuri.harvard.edu/~zhou for details). Our laboratory will be
equipped with 64-processor PC clusters and some SGI/Dec alpha
workstations.  The university Center for Computational Research also
has 128-processor Origin 2000, 28-processor SP2, and a cluster of 64
Sun Ultra 5 workstations.  Please send your CV with cover letter, and
the names, addresses, and phone numbers of two referees familiar with
your work. Email to zhou@tammy.harvard.edu with plain text file or
postscript file is preferred. Regular mail should send to Dr. Yaoqi
Zhou, Department of Chemistry and Chemical Biology, Harvard
University, 12 Oxford St. #232, Cambridge, MA 02138, or Department of
Physiology and Biophysics, 124 Sherman Hall, University at Buffalo,
State University of New York Buffalo, New York 14214 after July 1,
2000. State University of New York is an Equal Opportunity/Affirmative
Action Employer.
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