From owner-repertoires@net.bio.net Sun Nov 05 22:00:00 1995 Path: biosci!daresbury!sunsite.doc.ic.ac.uk!dispatch.news.demon.net!demon!btnet!newsfeed.internetmci.com!news.sprintlink.net!in1.uu.net!li.net!sahslib From: sahslib@newshost.li.net (St.Anthony HS Library) Newsgroups: bionet.molecules.repertoires Subject: Request info on BRCA gene- Breast cancer gene Date: 5 Nov 1995 12:47:05 GMT Organization: LI Net (Long Island Network) Lines: 14 Message-ID: <47ibo9$6i6@linet02.li.net> NNTP-Posting-Host: linet04.li.net X-Newsreader: TIN [version 1.2 PL2] [ Article crossposted from bionet.genome.chromosomes ] [ Author was St.Anthony HS Library ] [ Posted on 5 Nov 1995 12:45:00 GMT ] I am a 16-year old junior at Sachem School North, involved in a genetics laboratory internship. My fellow interns and I are interested in studying the BRCA gene. If anyone can tell me either the Base Sequence of the entire Breast Cancer (BRCA) gene, or can at least tell me HOW MANY BASE PAIRS THERE ARE, please E-Mail this account as soon as possible. I thank all of you for your assistance. Jonathan Kui From owner-repertoires@net.bio.net Sun Nov 05 22:00:00 1995 Path: biosci!daresbury!sunsite.doc.ic.ac.uk!dispatch.news.demon.net!demon!btnet!newsfeed.internetmci.com!in1.uu.net!li.net!sahslib From: sahslib@newshost.li.net (St.Anthony HS Library) Newsgroups: bionet.molecules.repertoires Subject: Requestion info on BRCA gene- Breast cancer gene Date: 5 Nov 1995 12:45:34 GMT Organization: LI Net (Long Island Network) Lines: 14 Message-ID: <47ible$6i6@linet02.li.net> NNTP-Posting-Host: linet04.li.net X-Newsreader: TIN [version 1.2 PL2] [ Article crossposted from bionet.genome.chromosomes ] [ Author was St.Anthony HS Library ] [ Posted on 5 Nov 1995 12:45:00 GMT ] I am a 16-year old junior at Sachem School North, involved in a genetics laboratory internship. My fellow interns and I are interested in studying the BRCA gene. If anyone can tell me either the Base Sequence of the entire Breast Cancer (BRCA) gene, or can at least tell me HOW MANY BASE PAIRS THERE ARE, please E-Mail this account as soon as possible. I thank all of you for your assistance. Jonathan Kui From owner-repertoires@net.bio.net Tue Nov 07 22:00:00 1995 Path: biosci!agate!dog.ee.lbl.gov!news.cs.utah.edu!cs.utexas.edu!news.sprintlink.net!dispatch.news.demon.net!demon!sunsite.doc.ic.ac.uk!daresbury!not-for-mail From: "Janet Clench, Library, Tel:(39 6)91093220" Newsgroups: bionet.molecules.repertoires Subject: ... and here's another 2-week reference update for molreps. Date: 8 Nov 1995 14:17:47 -0000 Lines: 61 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <47qe6b$sh3@mserv1.dl.ac.uk> Original-To: molreps@dl.ac.uk **************************************************** SUBJECT: Combinatorial & Phage Libraries DATE: October 30, November 6, 1995 **************************************************** Acta Crystallographica Section D - Biological Crystallography 51: Part 5 (SEP 1 1995) A Gonzalez, C Nave, DA Marvin Pf1 filamentous bacteriophage: Refinement of a molecular model by simulated annealing using 3.3 angstrom resolution X-ray fibre diffraction data 792-804 Journal of Magnetic Resonance Series A 116: 2 (OCT 1995) WL Jarrett, CG Johnson, LJ Mathias Solid-state NMR characterization of C-13- and N-15-labeled phthalimides as model compounds for studying polyimides 156-160 Science 270: 5234 (OCT 13 1995) G Briceno, HY Chang, XD Sun, PG Schultz, XD Xiang A class of cobalt oxide magnetoresistance materials discovered with combinatorial synthesis 273-275 Biochemistry 34: 39 (OCT 3 1995) BL Mark, TC Terwilliger, MR Vaughan, DM Gray Circular dichroism spectroscopy of three tyrosine-to- phenylalanine substitutions of fd gene 5 protein 12854-12865 Chemistry & Biology 2: 9 (SEP 1995) BA Katz, RM Stroud, N Collins, BS Liu, R Arze Topochemistry for preparing ligands that dimerize receptors 591-600 Chemistry & Biology 2: 9 (SEP 1995) MC Pirrung, JHL Chau, JL Chen Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library 621-626 Biochemistry 34: 38 (SEP 26 1995) AR Khan, KA Williams, JM Boggs, CM Deber Accessibility and dynamics of Cys residues in bacteriophage IKe and M13 major coat protein mutants 12388-12397 Journal of Biological Chemistry 270: 40 (OCT 6 1995) BC Wang, LA Dickinson, E Koivunen, E Ruoslahti, T Kohwishigematsu A novel matrix attachment region DNA binding motif identified using a random phage peptide library 23239-23242 Drug Development Research 36: 1 (SEP 1995) A Furka History of combinatorial chemistry 1-12 From owner-repertoires@net.bio.net Tue Nov 14 22:00:00 1995 Path: biosci!bloom-beacon.mit.edu!satisfied.apocalypse.org!news.xensei.com!news From: inquiries@healthtech.com (Cambridge Healthtech Institute) Newsgroups: bionet.molecules.repertoires Subject: Solid Phase Synthesis meeting announcement Date: Wed, 15 Nov 1995 17:51:05 GMT Organization: Cambridge Healthtech.Institute Lines: 60 Message-ID: <48d9b9$beq@xensei3.xensei.com> Reply-To: inquiries@healthtech.com NNTP-Posting-Host: chi.xensei.com X-Newsreader: Forte Free Agent 1.0.82 Cambridge Healthtech Institute, producer of meetings of interest to biomedical professionals is announcing their upcoming meeting, "Solid Phase Synthesis: Developing Small Molecule Libraries," to be held on February 1-2, 1996 at the Hotel Del Coronado in Coronado California. (This meeting is preceded by "Third Annual Exploiting Molecular Diversity, Small Molecule Libraries for Drug Discovery," to be held January 29-31, 1996 ). Topic Description: The opportunity represented by combinatorial libraries has focused attention on innovations in rapid, automated solid- phase synthesis, particularly of small molecules. Solid-phase synthesis, particularly in a high-throughput mode, requires a shift in thinking about the process, the chemistry, and other factors, including analytical techniques and organizational structure. The effect of different options such as which kind of support, different types of linkers, choice of solvents, and the chemistry being carried out will be examined. Issues related to management, automation, and quality control of solid-phase reactions, as well as identification of key challenges that need to be addressed, will be discussed. Session Chairs: Dr. John P. Devlin, ARRT International, Inc. Dr. Joseph C. Hogan, Jr., ArQule, Inc. Dr. Kim D. Janda, The Scripps Research Institute Dr. Barry E. Toyonaga, Ontogen Corporation Additional Speakers: Dr. Andrew M. Bray, Chiron Mimotopes Pty. Ltd. Dr. Balan Chenera, SmithKline Beecham Pharmaceuticals Dr. Ferenc Darvas, ComGenex Ltd. Dr. Reza Fathi, PharmaGenics, Inc. Dr. Guenter Grethe, MDL Information Systems, Inc. Dr. James R. Harness, Bohdan Automation, Inc. Dr. James R. Hauske, Arris Pharmaceutical Corporation Dr. Normand Hebert, Isis Pharmaceuticals, Inc. Dr. John S. Kiely, Torrey Pines Institute for Molecular Studies Dr. Viktor Krchnak, Selectide Corporation Dr. Joel F. Martin, Argonaut Technologies, Inc. Dr. John M. Nuss, Chiron Corporation Dr. Dinesh V. Patel, Affymax Research Institute Dr. Mark L. Peterson, Advanced ChemTech, Inc. Dr. Keith Russell, Zeneca Pharmaceuticals Dr. Christine M. Tarby, CombiChem, Inc. Advance registration deadline: December 15, 1995. For more information, contact Cambridge Healthtech Institute. (For faster response, please include full mailing address and facsimile number with your information request). ______________________________ Cambridge Healthtech Institute 1037 Chestnut Street Newton Upper Falls, MA 02164 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ tel: 617.630.1300 fax: 617.630.1325 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ inquiries@healthtech.com World Wide Web http://www.healthtech.com/conferences From owner-repertoires@net.bio.net Tue Nov 14 22:00:00 1995 Path: biosci!daresbury!not-for-mail From: "Andrew, Tel. +396-91093434" Newsgroups: bionet.molecules.repertoires Subject: Forwarded message on PCR primers database Date: 15 Nov 1995 17:39:37 -0000 Lines: 63 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <48d8kp$obh@mserv1.dl.ac.uk> Original-To: molreps@dl.ac.uk Forwarded from: bionet.announce Msg # 2460 Originally posted by: Benny Shomer (bshomer@EBI.ac.uk) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The PCR Primers database - First Announcement. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ I'm happy to announce the release of the PCR primers database. This is a practical database of fully tested and optimized primers for PCR reactions. The database contains all the data items required to reproduce precisely the reaction conditions of the submitting author and contact details in case of a need. Initially, the database is release to the public practically empty, since it is based on submissions from colleagues and not on journal scanning. Nevertheless, it is being released with the required definitions, documentation, data submission form and a data submission system through WWW. The data will be available by ftp. In the near future it will be made searchable through the WWW server. Data submissions are highly welcome. It is MUCH preferred that users will submit information through a specially dedicated WWW based system. This system is not only convenient to use, but it also saves much work in preparing the submitted information for release. Users who have no access to the WWW can use a data submission form that can be sent by email. I will post the data submission form in another message. The database home page can be accessed through EBI's home page at: http://www.ebi.ac.uk/ in the databases area, or directly at: http://www.ebi.ac.uk/primers_home.html The data can be obtained through anonymous ftp to: ftp.ebi.ac.uk under: /pub/databases/primers/primers.dat (but it now has only 3 entries... :) Best wishes and good luck with your PCR experiments!!! Benny. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Benny Shomer External Biological Liaison Officer, EMBL outstation - The EBI, Hinxton Hall, Hinxton,Cambridge CB10 1RQ, UK Tel: +44-223-494437 Fax: +44-223-494468 Email: bshomer@EBI.ac.uk http://www.ebi.ac.uk/ebi_docs/staff/benny.html ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ From owner-repertoires@net.bio.net Tue Nov 14 22:00:00 1995 Path: biosci!bloom-beacon.mit.edu!satisfied.apocalypse.org!news.xensei.com!news From: inquiries@healthtech.com (Cambridge Healthtech Institute) Newsgroups: bionet.molecules.repertoires Subject: Announcement of "Exploiting Molecular Diversity" Date: Wed, 15 Nov 1995 17:40:55 GMT Organization: Cambridge Healthtech.Institute Lines: 73 Message-ID: <48d8o8$bch@xensei3.xensei.com> Reply-To: inquiries@healthtech.com NNTP-Posting-Host: chi.xensei.com X-Newsreader: Forte Free Agent 1.0.82 Cambridge Healthtech Institute, producer of meetings of interest to biomedical professionals is announcing their upcoming meeting, "Third Annual Exploiting Molecular Diversity, Small Molecule Libraries for Drug Discovery," to be held January 29-31, 1996 at the Hotel Del Coronado in Coronado California. (This meeting is to be immediately followed by "Solid Phase Synthesis: Developing Small Molecule Libraries," to be held on February 1-2, 1996). Topic Description: The use of combinatorial libraries has rapidly moved from curiosity to a fundamental technique that is revolutionizing high-throughput screening for drug discovery. The technology addresses a prime bottleneck, which has been the limitation of the available diversity of compounds to be screened. Further progress is still needed to expand diversity, to optimize strategies for identifying new leads, and for analoging of current leads. The progress of programs at many of the leading firms using combinatorial libraries, as well as innovations by various newer entrants into the field, will be presented. The third day of the meeting will feature targets and resulting compounds being developed by pharmaceutical and biotechnology companies. Session Chairs: Dr. Kevin Burgess, Texas A & M University Dr. Irwin Chaiken, University of Pennsylvania School of Medicine Dr. Richard A. Houghten, Torrey Pines Institute for Molecular Studies and Houghten Pharmaceuticals, Inc. Dr. Stuart A. Kauffman, Sante Fe Institute Dr. Michael R. Pavia, Sphinx Pharmaceuticals Dr. Michael Pirrung, Duke University Additional Speakers: Dr. John J. Baldwin, Pharmacopeia, Inc. Dr. Barr E. Bauer, MDL Information Systems, Inc. Dr. Douglas S. Clark, University of California, Berkeley, and EnzyMed,Inc. Dr. P. Dan Cook, Isis Pharmaceuticals, Inc. Dr. Richard Cramer, Tripos, Inc. Dr. E. Keith Davies, Chemical Design Ltd. Dr. Manoj C. Desai, Chiron Corporation Dr. Sheila DeWitt, DIVERSOMER Technologies, Inc. Dr. Robert O. Fox, The University of Texas Medical Branch at Galveston Dr. Mark A. Gallop, Affymax Research Institute Dr. Cheryl D. Garr, Panlabs Incorporated Dr. Todd L. Graybill, 3-Dimensional Pharmaceuticals, Inc. Dr. Joseph C. Hogan, Jr., ArQule, Inc. Dr. Michael Kahn, Molecumetics Ltd. Dr. Michal Lebl, Selectide Corporation/Hoechst Marion Roussel Dr. Christopher J. Molineaux, Pharmaceutical Peptides, Inc. Dr. Peter L. Myers, CombiChem, Inc. Dr. Peter V. Pallai, Procept, Inc. Dr. Alex Polinsky, Alanex Corporation Dr. Steven L. Teig, CombiChem, Inc. Dr. Katie A. Thompson, ChromaXome Corporation Dr. Barry E. Toyonaga, Ontogen Corporation Dr. Gary T. Wang, Abbott Laboratories Dr. Mark A. Wuonola, SCRIPTGEN Pharmaceuticals, Inc. Advance registration deadline: December 15, 1995. For more information, contact Cambridge Healthtech Institute. ______________________________ Cambridge Healthtech Institute 1037 Chestnut Street Newton Upper Falls, MA 02164 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ tel: 617.630.1300 fax: 617.630.1325 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ inquiries@healthtech.com World Wide Web http://www.healthtech.com/conferences From owner-repertoires@net.bio.net Wed Nov 22 22:00:00 1995 Path: biosci!daresbury!not-for-mail From: "Janet Clench, Library, Tel:(39 6)91093220" Newsgroups: bionet.molecules.repertoires Subject: This week's updates of mol rep references. Date: 23 Nov 1995 16:42:01 -0000 Lines: 31 Sender: lpddist@mserv1.dl.ac.uk Distribution: bionet Message-ID: <49288p$ps@mserv1.dl.ac.uk> Original-To: molreps@dl.ac.uk *************************************************** SUBJECT: Combinatorial & Phage Libraries DATE: November 20, 1995 *************************************************** Journal of Biological Chemistry 270: 43 (OCT 27 1995) MS Dennis, A Herzka, RA Lazarus Potent and selective Kunitz domain inhibitors of plasma kallikrein designed by phage display 25411-25417 Journal of Immunological Methods 186: 1 (OCT 12 1995) EL Davies, JS Smith, CR Birkett, JM Manser, DV Andersondear, JR Young Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes 125-135 Journal of Molecular Biology 253: 3 (OCT 27 1995) DJ Tobias, J Gesell, ML Klein, SJ Opella A simple protocol for identification of helical and mobile residues in membrane proteins 391-395 Proceedings of the National Academy of Sciences of the United States of America 92: 22 (OCT 24 1995) PL Zhao, R Zambias, JA Bolognese, D Boulton, K Chapman Sample size determination in combinatorial chemistry 10212-10216 From owner-repertoires@net.bio.net Mon Nov 27 22:00:00 1995 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molecules.repertoires Subject: IMPORTANT: BIOSCI miniFAQ Date: 28 Nov 1995 02:01:16 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 196 Sender: daemon@net.bio.net Distribution: world Message-ID: <199511281000.CAA28446@net.bio.net> NNTP-Posting-Host: net.bio.net This is a new "miniFAQ" designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. Contents: -------- 1) What to do about "spams," i.e., junk mail, ads, etc. 2) Examples of subscribing and unsubscribing to the mailing lists. 3) How to access BIOSCI/bionet newsgroup archives. 4) The BIOSCI user address and research interest directory. 1) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups) and mailing lists. The same postings are distributed on both media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the newsgroups from about 95% of the spams that are being sent to date. This means that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings. Unfortunately there are easy ways for determined spammers to override the moderation mechanism. We are working on new systems to provide access to our newsgroups over the WWW. These should be available soon, probably November 1995, and will allow you to use your Web browser to look at the news postings. While this will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. 2) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 3) How to access BIOSCI/bionet newsgroup archives. -------------------------------------------------- Back postings of all BIOSCI/bionet newsgroups can be found on the World Wide Web at URL http://www.bio.net/. There are several searchable newsgroup indices at this site. E-mail users can search the BIOSCI archives by using our waismail e-mail server. For instructions send the message help to waismail@net.bio.net. Leave the Subject: line blank (anything entered on the Subject: line is ignored). 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net