From owner-repertoires@net.bio.net Sun Sep 07 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Ralf Landgraf Newsgroups: bionet.molecules.repertoires Subject: choice of vector for display of EGF-like domain Date: 8 Sep 1997 02:04:45 -0700 Organization: University of California, Los Angeles Lines: 42 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <340F3E01.230C@mbi.ucla.edu> Reply-To: landgraf@mbi.ucla.edu NNTP-Posting-Host: net.bio.net I have a question regarding the right choice of vectors for phage display. I am planing to display a 60 amino-acid EGF-like domain (with an even number of disulfides) as a fusion to the M13 gene III protein, using a 3 + 3 system. I have two vectors (the Stratagene Surfzap and Pharmacia pCANTAB-5E) available from projects in which an unrelated protein and ScFv's were displayed. I was wondering if somebody had experience with either one of these two vectors that would help me to decide which one to use for the display of the relatively small EGF-like domain? I have used the Surfzap vector in the past but for this project I would have to introduce an additional affinity tag and amber stop codon myself to get the option of recovering and purifying soluble protein in suppressor strains. That would be another unknown as far as expression is concerned. Using Surfzap would also require much longer oligos at the N-terminus because of it's unique location of the cloning site. I would like to avoid this to reduce errors caused by the oligo itself. At the moment I am in favor of the pCANTB vector. I would like to use the amber stop codon and E-tag for the purification of soluble recombinant EGF-like domains without the need for subcloning. The down side is that I have not seen applications of this vector that involve proteins other than antibodies.(I have to admit that I have not looked very hard) Thanks Ralf Landgraf Molecular Biology Inst. UCLA landgraf@mbi.ucla.edu From owner-repertoires@net.bio.net Sun Sep 07 23:00:00 1997 Path: biosci!biosci!not-for-mail From: lefranc@ligm.crbm.cnrs-mop.fr (Marie-Paule Lefranc) Newsgroups: bionet.molecules.repertoires Subject: IMGT NEWS Date: 8 Sep 1997 02:03:23 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 37 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <5uj0qr$i7a@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Colleague, I am pleased to send you the latest IMGT news for information and diffusion. With many thanks. Best regards. Professor Marie-Paule LEFRANC _____________________ IMGT NEWS-August 1997 "Alleles and mutations" IMGT, the international ImMunoGeneTics database, announces a STANDARDIZED description of allele polymorphisms and mutations for all immunoglobulin and T cell receptor V-REGIONs of all species, based on the IMGT unique numbering (IMGT NEWS - March 1997). Allele alignments and tables for the human IGH, IGK and IGL V-REGIONs are freely available at IMGT http://imgt.cnusc.fr:8104 IMGT initiator and coordinator : Prof. Marie-Paule Lefranc Laboratoire d'ImmunoGenetique Moleculaire, LIGM UMR 5535 (CNRS - Universite Montpellier II) 1919 route de Mende 34293 Montpellier Cedex 5 - France Tel: +33 (0)4 67 61 36 34 - Fax: +33 (0)4 67 04 02 31 lefranc@ligm.crbm.cnrs-mop.fr IMGT reference : Giudicelli et al., Nucleic Acids Research, 25, 206-211(1997) From owner-repertoires@net.bio.net Mon Sep 08 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Rita Stewart Newsgroups: bionet.molecules.repertoires Subject: PostDoc Advertisement Date: 9 Sep 1997 08:31:16 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 29 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <199709091519.QAA09891@listserv.rl.ac.uk> Reply-To: Rita Stewart NNTP-Posting-Host: net.bio.net POSTDOCTORAL FELLOW We have a position starting June 1998 on an NIH training grant in the area of hemostasis, thrombosis and inflammation, financed up to three years. We seek an individual with experience in protein biochemistry and/or molecular and cell biology. The research involves the interaction of protein ligands with blood or vessel wall cells. The techniques involve the use of peptides, recombinant proteins, monoclonal antibodies and transfected cells to probe the requirements and consequences of the interaction between the ligand and its receptor. No teaching duties are required. The Sol Sherry Thrombosis Research Center of Temple University has existed as a research department in the Medical Schoolfor 27 years. A multidisciplinary group of investigators who collaborate intensively and an extensive collection of common equipment and facilities ensure a stimulating and productive environment. Send CV to: Robert W. Colman, M.D. Sol Sherry Thrombosis Research Center Temple University School of Medicine 3400 North Broad Street Philadelphia, PA 19140 FAX: 215-707-2783 E-mail: colmanr@astro.ocis.temple.edu From owner-repertoires@net.bio.net Mon Sep 08 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Rita Stewart Newsgroups: bionet.molecules.repertoires Subject: PostDoc Advertisement phosphodiesterases Date: 9 Sep 1997 08:48:01 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 21 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <199709091532.QAA09970@listserv.rl.ac.uk> Reply-To: Rita Stewart NNTP-Posting-Host: net.bio.net POSTDOCTORAL POSITION Available immediately at Temple University School of Medicine in the Sol Sherry Thrombosis Research Center. Studies on cyclic nucleotide phosphodiesterases with affinity labels to identify catalytic sites, isolation of peptides, identification of amino acids modified, kinetics. Skills at protein purification and/or expression systems including yeast are desirable. Recent Ph.D. preferred; no citizenship limitations. Contact Robert W. Colman, M.D., Director, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, phone (215) 707-4665, FAX (215) 707-2783, E-mail colmanr@astro.temple.edu. From owner-repertoires@net.bio.net Tue Sep 09 23:00:00 1997 Path: biosci!biosci!not-for-mail From: William Baricos Newsgroups: bionet.molecules.repertoires Subject: Post doctoral position Date: 10 Sep 1997 02:10:49 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 19 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <199709091918.UAA10906@listserv.rl.ac.uk> Reply-To: William Baricos NNTP-Posting-Host: net.bio.net Post doctoral position available (as research supplement to NIH grant) for underrepresented minority individual (African American (Black), Hispanic American, Native American Indian, Alaskan Natives, and Pacific Islanders) to study the role of decreased proteolysis as a mechanism of ECM accumulation in progressive renal disease. See NIH Guide, Vol 25, number 3, February 9, 1996 for details and more information. If eligible contact Dr. William H. Baricos Baricosw@mailhost.tcs.tulane.edu for more information. From owner-repertoires@net.bio.net Sun Sep 14 23:00:00 1997 Path: biosci!biosci!not-for-mail From: "z. g. zhao" Newsgroups: bionet.molecules.repertoires Subject: Electronic Conference on Synthetic Organic Chemistry Date: 15 Sep 1997 01:52:28 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 49 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <341B459D.1AEF@azcc.arizona.edu> Reply-To: "z. g. zhao" NNTP-Posting-Host: net.bio.net [Apologies for any duplication] Dear mol-diversity members: The first international electronic conference page on synthetic organic chemistry has been activated on September 1st, 1997. Every one on this list is invited to view the posters at: http://www.unibas.ch/mdpi/ecsoc/posters.htm All comments should be sent directly by e-mail to: ecsoc@listserv.arizona.edu Be sure to put the poster number (such as A0001 for the first poster) as the subject of your e-mail, so all comments can be catagorized under the poster number. Since this commenting privilege was only granted to ecsoc listmembers, please be sure to subscribe to the ecsoc list before you send your comments. To subscribe, just send a one-line message: Subscribe ecsoc firstname lastname to: listserv@listserv.arizona.edu You must send your comments from the e-mail address you registered at the ecsoc list. If you use Netscape Mail or mail softwares with other web browsers, please reconfigure the mail option with the e-mail address you registed at the ecsoc list. For convenience, we have uploaded the titles (some poster have abstract there) onto the listserv archive page at: http://listserv.arizona.edu/lsv/www/ecsoc.html If you want to view all the comments about a particular poster in this archive page, simply go to the section named by the poster's number. If you have any questions about the conference, please contact the conference organizer at ecsoc-1@mdpi.org If you ahve questions about the listserv and the listserv archive page, please let me know. Thank you for your attention! Z.G. Zhao ZZhao@azcc.arizona.edu From owner-repertoires@net.bio.net Sun Sep 14 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Alicia Gomez Roig Newsgroups: bionet.molecules.repertoires Subject: phage display patents Date: 15 Sep 1997 04:55:11 -0700 Organization: MERCK-LBI (Barcelona) Lines: 8 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <341D0363.448@mailserver.bci.merck.de> NNTP-Posting-Host: net.bio.net I'm very intersted on patents with the phage display technology, where can I find information about this topic? ( I recently read an article in the "Nature Biotechnology"vol 15 june 1997) Thank you for your time, sincerely Alicia Gomez-Roig. From owner-repertoires@net.bio.net Tue Sep 16 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Shu-Kun Lin Newsgroups: bionet.molecules.repertoires Subject: Re: Molecular Diversity Journal Date: 17 Sep 1997 01:46:04 -0700 Organization: University of Basel, Switzerland Lines: 48 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <01INQUM57TMU8YGSXZ@ubaclu.unibas.ch> Reply-To: Shu-Kun Lin NNTP-Posting-Host: net.bio.net MOLECULES (ISSN 1420-3049, CODEN: MOLEFW, Vol. 1, 1996; Vol. 2, 1997) also publishes papers on molecular diversity, including combinatorial synthesis and parallel synthesis robotics of multi-step synthesis applications of compound collections (such as high throughput screening) and combinatorial compound libraries molecular diversity assessments compound archives management compound database design and management We publish papers very rapidly and regularly (online monthly, CD, and print yearly). MOLECULES maintains a rigorous peer-review system under an international editorial board. It is indexed and abstracted by Chemical Abstracts; Science Citation Index Expanded; Research Alert; Chemistry Citation Index; and Current Contents. It is published by Molecular Diversity Preservation International (MDPI) in Switzerland. Website: http://www.mdpi.org/molecules/ Contribution of papers and suggestions are welcomed. Shu-Kun Lin Editor-in-Chief, MOLECULES > Can someone tell me what has happened with the journal, Molecular > Diversity? Is it still being printed? What was the last issue published? > What is it's future? > Thanks, > Steve Wood > Procter & Gamble > Cincinnati, OH --------------------------------------------------------- Dr. Shu-Kun Lin Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland MDPI http:// www.mdpi.org/ Molecules: http://www.mdpi.org/molecules/ ECSOC-1: http://www.mdpi.org/ecsoc-1/ e-mails: Lin@ubaclu.unibas.ch Lin@mdpi.org Tel. +41 79 322 3379, Fax +41 61 302 8918 -------------------------------------------------------- From owner-repertoires@net.bio.net Tue Sep 16 23:00:00 1997 Path: biosci!biosci!not-for-mail From: "Stephen G. Wood" Newsgroups: bionet.molecules.repertoires Subject: Molecular Diversity Journal Date: 17 Sep 1997 01:43:55 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 12 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: Reply-To: "Stephen G. Wood" NNTP-Posting-Host: net.bio.net Can someone tell me what has happened with the journal, Molecular Diversity? Is it still being printed? What was the last issue published? What is it's future? Thanks, Steve Wood Procter & Gamble Cincinnati, OH From owner-repertoires@net.bio.net Tue Sep 16 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Shu-Kun Lin Newsgroups: bionet.molecules.repertoires Subject: MOLECULES, sample paper on molecular diversity Date: 17 Sep 1997 03:17:32 -0700 Organization: University of Basel, Switzerland Lines: 32 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <01INQY856B548YHCFI@ubaclu.unibas.ch> Reply-To: Shu-Kun Lin NNTP-Posting-Host: net.bio.net MOLECULES, sample papers on molecular diversity topic You may ask Dr. Eduard Felder (Pharmaceuticals Division, Novartis, 4002 Basel, Switzerland. e-mail: Eduard.Felder@pharma.novartis.com) to send you a hard copy of his recent paper published in Molecules 1997, vol.2, 17 - 30, by Andreas L. Marzinzik and Eduard R. Felder, "Combinatorial Libraries on Rigid Scaffolds: Solid Phase Synthesis of Variably Substituted Pyrazoles and Isoxazoles" You may download this paper from http://mdpi.org/molecules/papers/jan97p5.pdf using UserID: moldiv9 Passwor: moldiv9 Best regards, Shu-Kun Lin --------------------------------------------------------- Dr. Shu-Kun Lin Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland MDPI http:// www.mdpi.org/ Molecules: http://www.mdpi.org/molecules/ ECSOC-1: http://www.mdpi.org/ecsoc-1/ e-mails: Lin@ubaclu.unibas.ch Lin@mdpi.org Tel. +41 79 322 3379, Fax +41 61 302 8918 -------------------------------------------------------- From owner-repertoires@net.bio.net Sun Sep 28 23:00:00 1997 Path: biosci!biosci!not-for-mail From: John McCafferty Newsgroups: bionet.molecules.repertoires Subject: Report on Galway meeting Date: 29 Sep 1997 05:20:13 -0700 Organization: CAT Lines: 27 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <342B973C.5BFC@camb-antibody.co.uk> Reply-To: john.mccafferty@camb-antibody.co.uk NNTP-Posting-Host: net.bio.net Dear All, There is a short report on the recent Joint meeting of the "Phage Club" and the "Protein and Peptide Science Group" of the Biochemical Society at their web site. See: http://www.brookes.ac.uk/ppsg/ and follow link to "past meetings" Regards, John ----------------------------------------------- John McCafferty, Cambridge Antibody Technology, The Science Park, Melbourn, Cambs SG8 6JJ Phone : 01763 263233 (Xt 215) Direct: 01763 269215 Fax : 01763 263413 e.mail: john.mccafferty@camb-antibody.co.uk --------------------------------------------------------- From owner-repertoires@net.bio.net Sun Sep 28 23:00:00 1997 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 29 Sep 1997 01:30:07 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <199709280900.CAA11580@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-repertoires@net.bio.net Mon Sep 29 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Adriano Aguzzi Newsgroups: bionet.molecules.repertoires Subject: Winter Meeting: Growth & Death in the Nervous System Date: 30 Sep 1997 07:01:36 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 317 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <01BCC844.1159F250.adriano@pathol.unizh.ch> Reply-To: Adriano Aguzzi NNTP-Posting-Host: net.bio.net Dear Colleague, Here I would like to give you some information on the XVII meeting of the Swiss Society of Neuropathology, which will take place in St. Moritz (one of the most famous Swiss skiing resorts) in March 14-18th, 1998. This venue sports a 30-year-old tradition of bringing together neuropathologists, neuro-clinicians, and neuroscientists interested in disease mechanisms. We specifically welcome the participation of "Aerzte im Praktikum", medical students and PhD students, who will enjoy a 50% discount on the registration fee (details below). In order to foster intense communication in-house and on the skiing slopes, the meeting will be residential at the following address: Hotel Laudinella Address/Adresse: 7500 St. Moritz Telephone: ++41-81-832 21 31 Telefax: ++41-81-833 57 01 Main topic will be "Growth and Death in the Nervous System". We will have sessions on experimental and clinical neurooncology, on the genetics of neural cancer, on neurodegeneration, on prion diseases, and on neuroinflammatory diseases. Down this very long e-mail message, you can find the following items: 1. How to get more information about this meeting 2. How to register 3. How to submit abstracts (for oral or poster communication) 4. A preliminary program 5. How to reach St. Moritz 6. Legal stuff (deadlines, reimbursement etc.) 7. Acknowledgments I sincerely hope to welcome you in St. Moritz. With best regards Adriano Aguzzi, M.D., MRCPath Professor of Neuropathology and Head, Inst. of Neuropathology University Hospital of Zurich, Schmelzbergstrasse 12 CH-8091 Zurich, Switzerland Tel. ++41-1-2552107, fax ++41-1-2554402 ________________________________________________________ 1. How to get more information about this meeting At the bottom of this e-mail you will find a preliminary program, along with the list of plenary speakers who have confirmed their participation. More detailed information on the venue, on St. Moritz, and on the skiing conditions (including live camera pictures from the neighbouring mountains updated several times per day) can be found at our web site with the following address: http://www.unizh.ch/pathol/neuropath/StMoritz98/neuro17a.html If you wish us to mail information to you via regular "sneak mail" (including a poster announcing the meeting), please fill the form here and e-mail it back to us: ** BEGIN OF REQUEST FORM FOR ADDITIONAL INFORMATION ** *** ATTENTION: THIS IS NOT A REGISTRATION FORM !!! *** First and Middle Name: Family Name: : Title: Institution: Address: ZIP code: City (+ state for USA): Country: International dial code: City dial code: Phone no.: Fax No.: E-mail: ***** END OF REQUEST FORM FOR ADDITIONAL INFORMATION **** ________________________________________________________ 2. How to register The easiest way is to register on-line through our web site at address http://www.unizh.ch/pathol/neuropath/StMoritz98/neuro17a.html The web site mentioned above contains detailed information on the venue, on St. Moritz, and on the skiing conditions (including live camera pictures from the neighbouring mountains updated several times per day). In case you have any problems, or need clarifications, feel free to e-mail me to the following address: adriano@pathol.unizh.ch Alternatively, (but somewhat less conveniently)you can fill the following fields of e-mail registration form found below here, and e-mail it back to us! This way you can be sure that there will be no transcription mistakes. Finally (but much less conveniently), you can print out the e- mail registration form, and fax (or send) it to us at the following number: +41-1-255 4402 Registration will be confirmed by our office via regular mail, as soon as the due amount of fees (for registration, accommodation etc.) is remitted. METHODS OF PAYMENT: - We strongly favor payment via credit card (Euro/Master/VISA). However, we should alert you of the (slight) possibility that some malicious hackers may intercept the e-mail and misuse your card information. We believe that this is even less likely than the chance of developing e.g. Creutzfeldt-Jakob disease after consumption of beef, but we cannot take responsibility for it. - Alternatively, you can send us a cheque. For Eurocheques there is no charge, but our bank charges SFr. 20 for all other bank cheques (which, we agree with you, is outrageous but inevitable), and which you need to add to the total fee. - Finally, you can remit a direct bank wire transfer to the following account: 1103-0021.713, Zurcher Kantonalbank, Filiale Limmatquai (Clearing No.703), CH-8025 Zurich (Keyword: NP/KONGRESS St. MORITZ) - If you decide to send us a cheque or perform a wire transfer, we will be able to confirm registration only after receipt of proof of payment by regular mail. Below is the registration form. If you decide to register by e-mail (rather than by using the web site registration at http://www.unizh.ch/pathol/neuropath/StMoritz98/neuro17a.html), please fill every field by typing right after each semicolon. Do not change or delete any item to the left of the semicolons, lest our electronic processing system will not work properly. IMPORTANT: If you are registering more than one person (e.g. an accompanying person, or a co-worker), please fill and e-mail one registration form for each individual person to be registered. ****************************************************** ************** BEGIN OF REGISTRATION FORM ************ ****************************************************** Title: First and middle name: Family (last) name: Gender (M/F): Institution: Address: ZIP code: City (+ state for USA): Country: International dial code: City dial code: Phone no.: Fax No.: E-mail: Registration (type "x" after the appropriate field) - Regular, before Oct 31, 1997 (SFr. 200): - Student/AIP(send proof), before Oct 31, 1997 (SFr.100): - Accompanying, before Oct 31, 1997 (SFr. 20): - Regular, after Oct 31, 1997 (SFr. 250): - Student/AIP(send proof), after Oct 31, 1997 (SFr.150): - Accompanying, after Oct 31, 1997 (SFr. 50): Accommodation - 4 nights 14-18 March, including breakfast, tax, and many other goodies (brochure will be sent upon registration). (type "x" after the appropriate field) - single room "comfort"- LIMITED AVAILABILITY (SFr.540): - one bed in "comfort" double room (SFr. 440): - one bed in "comfort" triple room (SFr. 380): - single room "standard"- LIMITED AVAILABILITY (SFr.440): - one bed in "standard" double room (SFr. 380): - No accommodation requested (SFr. 0.00): Name of preferred roommate (if in double or triple room): Participation to social dinner - SFr. 60 (yes/no): Mode of payment (type "x" after the appropriate field) Payment by credit card (preferred)- yes/no: - card company (Euro/Master/VISA): - card number (xxxx xxxx xxxx xxxx): - card exp. date (mm-yy): - Payment by cheque - yes/no: - Eurocheque (no fee): - Any other cheque (add 20 SFr. processing fee): - Payment by bank transfer - yes/no: (please in this case send us proof of payment by mail) Total amount to be remitted: ******************************************************** ****************** END OF REGISTRATION FORM ************ ******************************************************** ________________________________________________________ 3. How to submit abstracts IMPORTANT: Deadline for submission is November 30th, 1997. - The language of the meeting is English. We will have both oral and poster sessions. Since we anticipate fierce competition for space in oral communications, oral format cannot be guaranteed in advance. If you submit an oral communication, you will be notified of acceptance before Dec. 31, 1997. In negative case, you will be given the option to present your work as a poster. At any rate, each participant can contribute only one oral communication (but an unlimited number of posters). - Electronic submission of the abstract is imperative for acceptance and for inclusion in the abstract booklet. The preferred way to submit an abstract is to e-mail it as a fully formatted word processor file attachment to the following address: Adriano@pathol.unizh.ch - Alternatively (but less conveniently), you can submit a "text-only" (i.e. unformatted) abstract. You can include the text in the body of your e-mail, or submit through our web site http://www.unizh.ch/pathol/neuropath/StMoritz98/neuro17a.html - Whenever possible, the length of each abstract should not exceed 500 words (but we will not be fiscal about this). You are highly welcome to include figures and drawings into your abstracts, as long as these can be incorporated into a MS-Word or RTF document. We can read almost all popular word processor formats for Windows and for Macintosh. MS Word for Windows, or "Rich Text Format" (RTF), give the least problems and are preferred. - Posters can be up to 150cm high, but may not be wider than 80cm. - Oral communications are limited to 10 minutes + 2 minutes discussion. Session chairmen and chairwomen are empowered to implement this time limit, if need be, with brachial force. CRUCIALLY IMPORTANT: In addition to the abstract proper, you are required to fill the fields of the following form: ***** BEGIN OF ABSTRACT SUBMISSION FORM****************** * PLEASE FILL EVERY FIELD BY TYPING AFTER EACH SEMICOLON* **** PLEASE SEND ONE FORM FOR EACH ABSTRACT SUBMITTED**** ********************************************************* Preferred format (oral/poster): Authors: Affiliations: ********** END OF ABSTRACT SUBMISSION FORM ************** ________________________________________________________ 4. Preliminary program ________________________________________________________ 5. How to reach St. Moritz The nearest airport is Zurich. Trains circulate between Zurich and St. Moritz hourly, and the trip Zurich-St. Moritz is approximately 3.5 hrs. The rail timetable can be consulted in the web at the following address: http://www.rail.ch/english/fpindex.htm A return ticket from Zurich costs CHF. 109.00 (2nd class) or CHF 181.00 (1st class)(as of July 1997). The complete train schedule, and all international flights to Zurich, can be found at our web site http://www.unizh.ch/pathol/neuropath/StMoritz98/neuro17a.html Hotel Laudinella will provide free transportation from and to the train station upon advance notification. ________________________________________________________ What happens if you need to cancel your registration and cannot come to the meeting? If cancellation is timely, your registration and accommodation fees will be refunded with the exception of our bank expenses. For late cancellation and "no show", fees will incur. Therefore, the policy outlined below will be applied: - Cancellation before 30.10.97: 95% refund or higher. A total of max. 5% of your remission must be held to cover our bank and credit card costs. In certain cases, bank costs will be less than 5%: we will then reimburse you accordingly, and up to 100%. Under no circumstances will reimbursement be less than 95%. - Cancellation on or after 30.10.97, but before 15.2.98: 80% refund - Cancellation on or after 15.2.98, or "no show" at meeting: regrettably in this case no refund is possible. ________________________________________________________ 7. Acknowledgments We are grateful to the following companies and institutions for financial support: - Swiss National Foundation - Novartis - KGF Foundation Basel - Boehringer Mannheim (Switzerland) - Julius-Muller-Stiftung - Glasmechanik - Leitz From owner-repertoires@net.bio.net Tue Sep 30 23:00:00 1997 Path: biosci!biosci!not-for-mail From: ben dunn Newsgroups: bionet.molecules.repertoires Subject: Home Page for Protein and Peptide Letters Date: 1 Oct 1997 07:09:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 21 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <199710011339.OAA24638@listserv.rl.ac.uk> Reply-To: ben dunn NNTP-Posting-Host: net.bio.net Protease Group: Please examine the following Web Site for current information on our journal, Protein and Peptide Letters: http://www.bscipubl.demon.co.uk/ppl/ You will find contents and abstracts of previous issues, instructions for manuscript preparation and submission, subscription information, etc. Either of us will be happy to answer questions regarding manuscripts. Best Regards, Ben M. Dunn, Editor-in-Chief Robin J. Leatherbarrow, Editor for European Submissions R.Leatherbarrow@ic.ac.uk From owner-repertoires@net.bio.net Tue Sep 30 23:00:00 1997 Path: biosci!biosci!not-for-mail From: Keith Rose Newsgroups: bionet.molecules.repertoires Subject: Postdoctoral position Date: 1 Oct 1997 01:24:24 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 55 Sender: daemon@net.bio.net Approved: a.wallace@qub.ac.uk Distribution: world Message-ID: <60q9j6$h8c@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Post-doctoral research position Department of Medical Biochemistry University of Geneva This post is available from 1 January 1997 for two years, to assist in a research project carrying out work on artificial proteins made by a combination of synthetic chemical techniques (SPPS) and site-specific chemical modification of existing proteins. See e.g. Rose, K., Facile synthesis of artificial proteins. J.Am.Chem.Soc. (1994) 116:30-33. Rose et al. A synthetic peptide-based polyoxime construct of high purity and activity. Mol.Immunol. (1995) 32:1031-1037. Rose et al. Natural peptides as building blocks for the synthesis of large protein-like molecules with hydrazone and oxime linkages. Bioconjugate Chemistry (1996) 7:552-556. Zeng et al. Synthesis of a new template with a built-in adjuvant and its use in constructing peptide vaccine candidates through polyoxime chemistry. J.Peptide Sci. (1996) 2:66-72. Werlen et al. Preparation of a trivalent antigen-binding construct using polyoxime chemistry: improved biodistribution and potential for therapeutic application. Cancer Res. (1996) 56:809-815. The project will use a combination of chemistry and protein biochemistry to create artificial proteins to target certain cells to elicit an immune response with application for AIDS and cancer vaccine biology. Applicants must have a Ph.D. in chemistry or biochemistry, with experience of peptide synthesis. Experience of protein structure modification would be an advantage, and in exceptional cases could compensate for lack of peptide-synthesis experience. Applicants should have a proven track record of high-quality work, attested by publications in major journals. Please send cv either by e-mail to rose@cmu.unige.ch or by fax (+41) 22 346 8758 naming at least two referees (please provide their e-mail and/or fax numbers as well as postal address). Applicants may obtain further particulars from Dr. Keith ROSE Department of Medical Biochemistry University of Geneva CMU 1, rue Michel Servet 1211 Geneva 4 Switzerland FAX (+41) 22 346 8758 Closing date: 30 October 1997 ---------------------------------------------------------