From owner-repertoires@net.bio.net Sun Feb 08 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Sandra Janousek Newsgroups: bionet.molecules.repertoires Subject: fellowship Date: 9 Feb 1998 02:18:01 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 59 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6bmj2r$l0p@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear All, please, find enclosed the call for application for a fellowship to work in my laboratory on "intracellular antibodies". I would be grateful if you could display this announcement on the board of your laboratory. Best regards, Antonino Cattaneo SISSA - ISAS Trieste Intracellular antibodies Applications are invited for a fellowship, to work in the laboratory of Prof. A. Cattaneo on intracellular antibodies (Biocca and Cattaneo (1995) Trends in Cell Biology 5, 248-252; Cattaneo and Biocca (eds.) (1997) Intracellular antibodies: development and applications, Springer-Verlag). Experience with molecular biology, phage-display technologies and mammalian cell culture would be an advantage. The position will be for one year, renewable for a second year. Applications must include a CV, list of publications and an outline of current research interests. Applicants should ensure that at least one letter of reference should be sent separately by the same date. Applications must be submitted by March 31, 1998 to: A. Cattaneo SISSA - ISAS Via Beirut, 2-4 34014 Trieste Italy Fax +39-40-3787-528 E-mail: cattaneo@sissa.it ******************************************************************** Sandra Janousek Biophysics Sector SISSA Via Beirut, 2-4 34014 Trieste Italy Tel. +39-(0)40-3787-235 Fax +39-(0)40-3787-249 E-mail: janousek@sissa.it ******************************************************************** From owner-repertoires@net.bio.net Sun Feb 08 22:00:00 1998 Path: biosci!biosci!not-for-mail From: "Cynthia S. Smagula" Newsgroups: bionet.molecules.repertoires Subject: 1998 Source Book Available Free to Researchers Date: 9 Feb 1998 01:42:14 -0800 Organization: BIOTA Publications Lines: 24 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <34D3A558.16DA@onramp.net> Reply-To: biota@onramp.net NNTP-Posting-Host: net.bio.net Obtain a free copy of the 1998 Source Book, a comprehensive guide to bioresearch products, by filling in the request form at the BioSupplyNet site: http://www.biosupplynet.com. The Source Book provides up-to-date information about molecular biology products, lab instrumentation, and supplies. 70,000 copies of the Source Book will be given to scientists this year. Biomedical researchers will find that the unique organization of the Source Book simplifies product searching and speeds the gathering of comparative information. The Source Book indexes products in 2250 categories, and provides up-to-date contact information, including WWW and e-mail addresses, for 3000 suppliers. Bench Basics comparative tables allow apples-to-apples comparisons of products. A special Lab Set-up Check List simplifies the process of putting together a new laboratory. The BioSupplyNet web site at http://www.biosupplynet.com ,the online companion to the Source Book, provides interactive access to Source Book information as well as several enhancements, including the BioToolKit, a searchable directory of 500 free molecular biology databases, analytic tools, and structural imaging software applications. From owner-repertoires@net.bio.net Sun Feb 08 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Robert Colman Newsgroups: bionet.molecules.repertoires Subject: Postdoc Date: 9 Feb 1998 02:46:48 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 43 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6bmlk1$n9d@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net POSTDOCTORAL FELLOW We have a position starting June 1998 on an NIH training grant in the area of hemostasis, thrombosis and inflammation, financed up to three years. We seek an individual with experience in protein biochemistry and/or molecular and cell biology. The research involves the interaction of protein ligands with blood or vessel wall cells. The techniques involve the use of peptides, recombinant proteins, monoclonal antibodies and transfected cells to probe the requirements and consequences of the interaction between the ligand and its receptor. No teaching duties are required. The Sol Sherry Thrombosis Research Center of Temple University has existed as a research department in the Medical School for 27 years. A multidisciplinary group of investigators who collaborate intensively and an extensive collection of common equipment and facilities ensure a stimulating and productive environment. Send CV to: Robert W. Colman, M.D. Sol Sherry Thrombosis Research Center Temple University School of Medicine 3400 North Broad Street Philadelphia, PA 19140 FAX: 215-707-2783 E-mail: colmanr@astro.ocis.temple.edu Please send to all recipients of the list. -- Robert W Colman MD Sol Sherry Professor of Medicine Director, Sol Sherry Thrombosis Research Center Temple University School of Medicine 3400 N Broad St Philia PA 19140 Ph 215- 707- 4665 FAX 215-707-2783 E Mail colmanr@astro.temple.edu From owner-repertoires@net.bio.net Sun Feb 08 22:00:00 1998 Path: biosci!biosci!not-for-mail From: BRUCE D KORANT 695-9493 Newsgroups: bionet.molecules.repertoires Subject: Post-doctoral Position Date: 9 Feb 1998 02:20:36 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6bmj6p$l3f@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Post-Doctoral/Visiting Scientist Position ----------------------------------------- Position available to identify and study cellular substrates for viral processing proteases (HIV, hepatitis C, and picornavirus), and their possible roles in virus' effects on cells. Applicants should be trained in enzymology, molecular biology or molecular cell biology. For an introduction to the project, see PNAS 93,9571 (1996); Adv Exp Med Biol 421,279 (1997). Excellent opportunity to work on new approaches to understanding the fundamental basis of viral cytopathology. DuPont Merck is a research-based pharmaceutical company with various programs aimed at regulating the molecular basis of human diseases, including a long history in viral diseases. For details, please contact: Dr Bruce Korant Dept of Molecular Biology Dupont Merck Co Experimental Station Bldg 336, room 24 Wilmington DE USA 19880-0336 tel 302 695 9493 fax 302 695 9420 Email korantbd@a1.lldmpc.umc.dupont.com From owner-repertoires@net.bio.net Mon Feb 09 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Wendy Warr Newsgroups: bionet.molecules.repertoires Subject: Ideas needed - new technologies Date: 10 Feb 1998 01:09:58 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 28 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6bnar5$dre@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Some time ago there was a message on the Molecular Diversity list about proof that drugs have been discovered through new technologies such as HTS and combichem. I seem to remember that only two compounds were mentioned and neither had actually reached the market place. In connection with a report I am writing, I am interested in any examples of drugs in clinical trials (or on the market) as a result of new technologies. Also, I would be pleased to hear from any vendors of new technologies (including, for example, synthesisers, UHTSS, miniaturization, use of chips etc.). Send me a paragraph telling me what you have to offer (include a URL if possible) and you might get some free publicity. Please reply to wendy@warr.com Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-repertoires@net.bio.net Wed Feb 11 22:00:00 1998 Path: biosci!biosci!not-for-mail From: James H Wikel Newsgroups: bionet.molecules.repertoires Subject: Post doc position available Date: 12 Feb 1998 02:45:27 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 25 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6buirv$rgf@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Lilly Research Laboratories has a position available in computational chemistry to develop and to apply computational methods in areas related to combinatorial chemistry. The appointment will be for a period of 1 to 2 years. Candidates for this position should have a Ph. D. or equivalent with a strong research background and experience in computational or physical chemistry. Candidates must be fluent in computer programming languages and workstation environments, have a working knowledge of synthetic chemistry, QSAR, genetic algorithms and neural networks, and have good interaction skills. Candidates would be expected to function in a multidisciplinary group composed of medicinal chemist, computational chemist, computer scientist, and statisticians. Interested candidate should apply to: Eli Lilly and Company, Chemistry Research Technology and Proteins, Manager, (Postdoctoral Applications DC 1533), Indianapolis, Indiana 46285 before April 15, 1998. Eli Lilly and Company is an equal employment opportunity employer and recruits, hires, trains, and promotes persons in all job titles without regard to race, color, religion, sex, national origin, age, disability, or veteran status. From owner-repertoires@net.bio.net Tue Feb 17 22:00:00 1998 Path: biosci!biosci!not-for-mail From: John Collins Newsgroups: bionet.molecules.repertoires Subject: Research jobs available in Germany Date: 18 Feb 1998 02:07:08 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6ccjtk$8uj@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Cosmix molecular biologicals GmbH, Braunschweig, Germany, founded in September 1997, by John Collins, is offering a screening service in the area of phage-display with a novel recombinatorial methodology called cosmix-plexing, which has been filed for patenting. We intend to stay ahead of the field with a vigorous innovative research and development programme. We are looking for research scientists to head development and contract collaboration projects, including work in the lab(!we are still quite small). The successful candidate will have a technician and a salary in excess of the present or last salary. There are possibilities to take shares in the company. The company has more than enough seed money for two years, by which time it should be paying its own way. New labs will be available in July. Starting date: immediately! More jobs will probably be available later in the year so let me know if you are looking for the mid-term. German language abilities are not essential. Please contact: John Collins, CEO, Cosmix molecular biologicals GmbH Professor of Genetics, TU Braunschweig Mascheroder Weg 1, D38124 Braunschweig, Germany Tel: 0531 6181 200 FAX: 0531 6181 202 Email: jco@gbf-braunschweig.de From owner-repertoires@net.bio.net Thu Feb 19 22:00:00 1998 Path: biosci!biosci!not-for-mail From: corniche information Newsgroups: bionet.molecules.repertoires Subject: rprotein L Date: 20 Feb 1998 03:06:57 -0800 Organization: BT Internet Lines: 15 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <34EC5247.2C8AB77A@corniche.com> NNTP-Posting-Host: net.bio.net An alternative to Protein A etc is available from Actigen. This can found at the searchable database http://www.corniche.com by searching for 'rprotein+l' 'protein+l' 'rprotein' or 'actigen' Corniche holds data on 50,000 life science related products and is free to use. From owner-repertoires@net.bio.net Thu Feb 19 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Michael Arlt Newsgroups: bionet.molecules.repertoires Subject: To all IRORI users Date: 20 Feb 1998 03:17:41 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6cjo0s$keg@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Hi folks! We would like to run a thermal induced reaction in MikroCans. Conditions are 110 degrees in xylene. IRORI recommends a temperature range from -70 to 80 degrees. My question: Has anyone ever tried to run a reaction above 80 degrees? What happened? Did the mesh "melt"? Or were the pores widened and resin was lost? Any hint is appreciated! All Combis have a nice weekend, Michael --------------------------------------------------------------------------- Dr. Michael Arlt m_arlt@merck.de Merck KGaA Tel. (49) 61 51 72 26 58 Pha Fo Med Chem/CNS FAX (49) 61 51 72 31 29 Frankfurter Str. 250 64271 Darmstadt/Germany Any opinions in this mail do not necessarily match the views of my company! --------------------------------------------------------------------------- From owner-repertoires@net.bio.net Sun Feb 22 22:00:00 1998 Path: biosci!biosci!not-for-mail From: "C.Database" Newsgroups: bionet.molecules.repertoires Subject: Chemdex-UK directory of UK chemists Date: 23 Feb 1998 07:32:35 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 50 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6cs1vh$k83@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Colleague, I am writing to draw your attention to the Chemdex-UK database of UK chemists on the internet. Chemdex-UK is a FREE World-Wide Web service on which you can search for chemists from chemistry departments in the UK. This is a government funded project, supported by the Royal Society of Chemistry, which aims to bring together colleagues from the industrial and academic chemical community as well as private contractors and other chemistry-related disciplines. If you are a professional chemist, then the advantages of being registered Chemdex-UK are obvious. Chemdex-UK is expected to help chemists identify and communicate with their colleagues from their desktop, completely free of charge. The system is fast and user-friendly and is available from anywhere in the world at the following WWW site: http://www-rsc.shef.ac.uk/chemdex-uk/ Chemdex-UK and the Royal Society of Chemistry are contacting members of staff from chemistry and chemistry-related departments in order to expand the coverage of the database. The purpose of this letter is therefore to request that you provide us with a few details regarding yourself, using the form found on the Chemdex-UK website. This form should not take long to complete, and should be of considerable value to yourself and the UK chemical community. The directives of the Data Protection Act will be strictly adhered to in order to protect both individual chemists and their employers. For this reason, we will ensure that each chemist registered on Chemdex-UK will have complete control over their associated data, and that the database will be regulated and scrutinised as closely as possible. We also require details regarding your Department. In order to reduce duplication, these details should be provided by an appropriate individual, your Department's Webmaster or Administrator for instance. A form for registering departmental details on Chemdex-UK can also be found on the website. If you do not have access to the WWW, we can supply an e-mail version of these forms. Many thanks, From owner-repertoires@net.bio.net Mon Feb 23 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Michal Opas Newsgroups: bionet.molecules.repertoires Subject: Calreticulin Workshop: Program & Gen Info Date: 24 Feb 1998 09:50:56 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 218 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6cv0rh$75s@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Colleague, We are delighted to announce that Calreticulin Workshop, devoted to the structure and function of calreticulin and related proteins, will take place on March 31 - April 2, 1998 in Banff, Alberta, Canada. The Calreticulin Workshop is a satellite meeting to the 8th Fisher Winternational Symposium on Cellular and Molecular Biology which will be held April 2-5, 1998, also at the Banff Conference Centre. The Workshop will provide unique opportunity to meet and interact with the scientists interested in calreticulin research in spectacular surroundings of Banff National Park in Canadian Rocky Mountains. We are sure that the Banff Calreticulin Workshop will be an important forum to share the latest findings and to develop future interactions. Calreticulin has been implicated to play a role in almost every aspect of cell biology as outlined in a brief overview below. We hope that the Workshop will be useful to sort out some of the latest discoveries and controversies concerning calreticulin and implication of this protein in a variety of biological systems. On the behalf of the Organizing Committee we would like to invite you to participate in the Workshop. Program of the 3rd Calreticulin Workshop "Wine & cheese" reception: March 31, 1998 8:00-10:30 pm Day 1 April 1 9:00-9:20 M. Opas Foreword ER Signalling 9:20-10:00 K. Mikoshiba "Molecular Dynamics in Brain Development" Calcium Chair: N.S.. Allen 10:00-10:40 T. Pozzan "Calreticulin as a Ca2+-buffer in the ER: evidence from overexpression studies" 10:40-11:20 KH. Krause "Ligand-gated and store-operated Ca2+ channels" 11:20-11:40 Coffee Break Calcium continued Chair: K. Mikoshiba 12:00-12:40 P. Camacho "Modulation of intracellular Ca2+ release and uptake by Calreticulin, Calnexin and Calmegin in Xenopus oocytes". 12:40-13:40 Lunch Break ER Chaperones Chair: R. Sontheimer 13:40-14:20 J. Bergeron "ER chaperones" 14:20-15:00 W. Nauseef "Roles of calreticulin and calnexin in ER 'quality control'" 15:00-15:40 D. Hebert "Calreticulin and calnexin: ER chaperone partners" 15:40-16:00 Coffee Break Disease Chair: K-H. Krause 16:00-16:40 R. Sontheimer Calreticulin Autoantibody Detection Employing a Ro Autoantigen-Binding Form of Recombinant Human Calreticulin" 16:40-17:20 P. Eggleton "Dual roles of calreticulin in autoimmunity and innate immunity" 17:20-18:00 B. Ritchie "Calreticulin in Blood Coagulation" 18:00-18:40 G. Needham "Tick Calreticulin" Day 2 April 2nd Gene Chair: T. Pozzan 09:00-09:40 R. Clark "Mechanisms of transcriptional regulation of calreticulin expression" 09:40-10:20 R. St.Arnaud "Specific developmental roles for calreticulin revealed by the knock-out mice" 10:20-11:00 D. Llewellyn "Stress-induced calreticulin expression" 11:00-11:20 Coffee Break Gene continued Chair: P. Eggleton 11:20-12:00 Nakhashi "Calreticulin and RNA processing" Plants 12:00-12:40 Allen/Wyatt/Tsou/Robertson "Calreticulin: a tool to alter cellular calcium in plant cells" 12:40-13:20 Navazio/Mariani "Calreticulin in plant cells" 13:20-14:20 Lunch Break Trafficking Chair: J. Bergeron 14:20-15:00 Johnson "Calreticulin in neuronal cells" Adhesion 15:00-15:40 Murphy-Ullrich "Calreticulin as a mediator of thrombospondin-stimulated focal adhesion disassembly" 15:40-16:00 Coffee Break Adhesion continued Chair: R. Clark 16:00-16:40 Dedhar "Perturbation of integrin mediated adhesion and Ca signalling in calreticulin-deficient cells. 16:40-17:20 Opas "Modulation of cellular adhesiveness by levels of expression of calreticulin" 17:20 Closing discussion >>> Conclusion M. Michalak SCIENTIFIC PROGRAM The scientific sessions for the Workshop will take place on Wednesday, April 1, 1998 from 9:00 AM - circa 7:00 PM. Slide projector, overhead projector, black-board and VHS VCR will be available for your presentations. Presentations: Each speaker will have ~40 minutes for presentation: please make presentation short enough to leave ~10 minutes for discussion. As you can see from the scientific program we are all working in extremely diverse areas of the biological sciences. Therefore, please make sure you devote at least 5 minutes of your talk to introduce the biological system you are studying. There is no need to send abstracts for the Workshop. Posters: Bring one or more posters if you wish! Posters shall be displayed throughout the Workshop, but we shall not formal poster sessions. In keeping with informal manner of the Workshop we expect posters to be on display throughout the duration of the Workshop to provide ample opportunity to discuss them at any time. REGISTRATION & ACCOMMODATION Schedule arrival date is on Tuesday, March 31, 1998. Upon arrival to the Banff Center please register for your accommodation at the Front Office in the foyer of the first floor of Donald Cameron Hall (Administration Building). Check-in time for your room is 2:30 PM on your day of arrival. Check-out time is 12:00 noon on your departure day. Your account may be paid in cash or by credit card (Visa, American Express, Master Card, EnRoute). RECEPTION There will be a reception ("wine & cheese") held for the Workshop participants on Tuesday, March 31, 1998 from 8:00 PM - 10:30 PM. Registration packets for the Workshop and name tags will be available during the reception. WINTERNATIONAL SYMPOSIUM The Calreticulin Workshop is a satellite meeting to the 8th Fisher Winternational Symposium on Cellular and Molecular Biology entitled "Membrane Proteins in Health and Disease" which will be held April 2-5, 1998, also at the Banff Conference Centre. Information about the meetings and registration forms can be obtained by contacting: Dr. Carol E. Cass, Chair Winternational Symposium Department of Oncology University of Alberta Cross Cancer Institute Edmonton, Alberta T6G 1Z2 (403) 432-8320 phone (403) 432-8425 fax email: sherron.becker@cancerboard.ab.ca GROUND TRANSPORTATION Bus service by Brewster Transportation is available directly from Calgary International Airport to Banff at 12:30 PM, 3:00 PM and 6:00 PM. The travel time is about 2 hours and the current one way fare is $28.00. Upon request buses will drop off passengers at the Banff Center. Brewster Transportation numbers are 403-762-6767 and 1-800-661-1152. If you have any further questions or special requirements please contact: Marek Michalak at (403) 492-2256 phone (403) 492-0886 fax E-mail: marek.michalak@ualberta.ca or Michal Opas at: (416) 978-8947 phone (416) 978-3954 fax E-mail: m.opas@utoronto.ca SEE YOU IN BANFF! Cheers Marek Michalak & Michal Opas From owner-repertoires@net.bio.net Tue Feb 24 22:00:00 1998 Path: biosci!biosci!not-for-mail From: repertoires Newsgroups: bionet.molecules.repertoires Subject: WE: job available in Germany: Research and Development Director Date: 25 Feb 1998 08:51:00 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 44 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <04E2DF2B722BD111968A0060974B445E092F1C@nt-server.morphosys.de> NNTP-Posting-Host: net.bio.net A wealth of achievement in biotechnology. Research and Development Director Exceptional package Germany MorphoSys (http://www.morphosys.de) is one of Europe's leading biotechnology companies. Based in Munich, the company has rapidly established an outstanding reputation for developing and applying new drug discovery technologies. As the company continues to expand its activities, it now seeks an R&D Director to take overall responsibility for research and development. The successful applicant will combine outstanding academic and commercial achievement with the ability to apply industrial disciplines and processes to the day-to-day management of our resources. An integral member of the senior management team, you will take a leading role in strategic analysis, the handling of scientific collaborations and commercial development. In addition, you will use your team leadership skills to guide our senior project scientists and their respective teams. Your qualifications and experience will include: * A PhD in the life sciences, probably in protein chemistry, genetics or molecular biology. * A successful track record in drug discovery research, the more recent portion of which should have been gained in the pharmaceutical or biotechnology industry. * A deep understanding of modern, genomics-based drug discovery. * A creative, forward-looking approach to science. This is a unique opportunity to join one of Europe's premier biotechnology companies at an exciting stage in its development. An attractive package, which includes stock options, is pitched to attract the very best candidate. Please call our advising consultant, Jacques Police, for an initial confidential discussion on +44 171 312 3223 (office hours) or +44 181 341 3107 (after 8pm local time), or send your full CV to him at Korn/Ferry International, 252 Regent Street, London W1R 5DA. Alternatively send by fax on +44 171 312 3383 or by e-mail to jacques.police@kornferry.com