From owner-repertoires@net.bio.net Thu Apr 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Menoret Newsgroups: bionet.molecules.repertoires Subject: hsp-immunity Date: 3 Apr 1998 02:14:56 -0800 Organization: @Home Network Lines: 8 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <352395CB.82AEEBF2@home.com> Reply-To: menoret@home.com NNTP-Posting-Host: net.bio.net The Center for Immunotherapy of Cancer and Infectious Diseases organize the first international conference on : Heat Shock Proteins in Immune Response. For more information visit ; http://www.hspimmunity.com From owner-repertoires@net.bio.net Thu Apr 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 3 Apr 1998 02:08:19 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199803281000.CAA28119@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-repertoires@net.bio.net Thu Apr 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: JOHN COLLINS Newsgroups: bionet.molecules.repertoires Subject: Rphagemid/ vectors Date: 3 Apr 1998 07:50:33 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 15 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6g2vka$s6h@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net I am looking for a phage or phagemid vector which doesn't have an Eco57I cut site.i.e. doesn't have the lambda pl promoter, Amp*resistance or a pBR322(ColE, /pMB1) replication origin. It may be asking a lot but it may be out there! e.g. an M13 phage-display vector with Tc-resistance for example? Thanks, John Collins From owner-repertoires@net.bio.net Thu Apr 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Didier.Wion@ujf-grenoble.fr Newsgroups: bionet.molecules.repertoires Subject: 6-methyl purine deoxyriboside Date: 3 Apr 1998 02:24:14 -0800 Organization: Universite Joseph Fourier - Grenoble 1, Grenoble, France Lines: 7 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6g2613$r5g$1@amazone.ujf-grenoble.fr> NNTP-Posting-Host: net.bio.net does anyone know where the drug 6-methyl purine deoxyriboside can be purchased? From owner-repertoires@net.bio.net Sun Apr 05 23:00:00 1998 Path: biosci!biosci!not-for-mail From: tyr-2@bones.biochem.ualberta.ca (Karl Fischer) Newsgroups: bionet.molecules.repertoires Subject: Re: Rphagemid/ vectors Date: 6 Apr 1998 01:37:29 -0700 Organization: Glaxo Heritage Research Institute Lines: 23 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: References: <6g2vka$s6h@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net In article <6g2vka$s6h@mserv1.dl.ac.uk>, JOHN COLLINS wrote: > I am looking for a phage or phagemid vector which doesn't have an Eco57I > cut site.i.e. doesn't have the lambda pl promoter, Amp*resistance or a > pBR322(ColE, /pMB1) replication origin. It may be asking a lot but it > may be out there! e.g. an M13 phage-display vector with Tc-resistance > for example? > > Thanks, > > John Collins posted and mailed Check out the classic phage vectors M13mp18 and mp19; a quick scan showed they don't have this r.e. site. Cheers Karl the hepB guy From owner-repertoires@net.bio.net Sun Apr 05 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Yoshihisa Inoue Newsgroups: bionet.molecules.repertoires Subject: 6th Meeting of Japan Combinatorial Chemistry Focus Group Date: 6 Apr 1998 01:44:53 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 99 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199804050329.MAA28526@gccss2.greencross.co.jp> NNTP-Posting-Host: net.bio.net Dear Netters, We are pleased to announce that Japan Combinatorial Focus Group, JCCF, will hold the 6th JCCF Meeting on April 27-28 at Senri Life Science Center in Osaka, Japan. And we have to say sorry that if you want to present your products at the booths, all the 30 booths are occupied already. Please try next meeting in Tokyo in September. But be careful if you want to attend, because around April 27-28 is Japanese vacation time. **************************************************************** 6th Meeting of Japan Combinatorial Chemistry Focus Group **************************************************************** April 27-28 Senri Life Science Center, Osaka, Japan April 27 1) 10:00-10:10 Opening Remarks 2) 10:10-11:00 Dr. Takashi Takahashi (Tokyo Inst. Technol.) "Libraries for Origosaccharide and DNA-Cleaving Molecule By Using Liquid / Solid Phase Synthesis" 3) 11:00-11:50 Dr. Naoki Sugimoto (Kounan Univ.) "New Biotechnology: Methods of Combinatorial Chemistry, Phage Display, and In Vitro Selection, and Their Target Molecules" 4) 11:50-12:15 Dr. Jason Armstrong (HTS Consulting Ltd.) "High Throughput Screening (HTS): Key issues and the move from research style HTS to industrial style Ultra-High Throughput Screening (UHTS)" (Lunch) (Vendor Demonstration) 5) 14:00-14:50 Mr. Thomas J. Baiga (Charybdis Technologies, Inc.) "Integrated Instrumentation for High Throughput Organic Synthesis" 6) 14:50-15:15 Dr. Darryl McConnell (Chiron Technologies Pty. Ltd.) "Small Molecule Library Synthesis with SynPhase(TM) Crowns" 7) 15:15-15:55 Dr. Yoon-Sik Lee (Seoul National Univ.) "Design of New Solid Supports for Combinatorial Chemistry" 8) 15:55-16:35 Dr. Sang Woong Kim (LG Chemical Ltd.) "Solid and Solution Phase Strategy for the Synthesis of Combinatorial Chemical Libraries" 9) 16:35-17:25 Dr. Timm Heinrich Jessen (EVOTEC Inc.) "EVOscreen, a Miniaturized Ultra-High Throughput Screeening System Based on Fluorescence Correlation Spectroscopy (FCS) and Additional Confocal Fluorescence Detection Methods All Having Single-Molecule Sensitivity" 18:00- Mixer April 28 10) 9:30- 9:55 Dr.Yoshihiro Itoh (Nara Sentan Technol. Univ.) "New Host-Guest Chemistry Using in Vitro Selection" 11) 9:55-10:20 Y.Fukase, M.Oikawa, Y.Sumida, K.Fukase and S.Kusumoto "Divergent Synthesis and Biological Activities of Lipid A Analogues" 12) 10:20-10:45 Dr. Kenichi Akaji (Kyoto Pharm. Univ.) "Macrocyclization on Solid Support Using Heck Reaction" 13) 10:45-11:10 T.Miyajima, K.Onogi, C.Okagaki and M.Yamada "Solid-Phase Synthesis of Dehydroalanine Derivatives" 14) 11:10-11:35 Robert Rice, James Rusnak, Fumiaki Yokokawa, Siho Yokokawa, Donald Messner, Alton Boynton, Peter Wipf and John Lazo (University of Pittsburgh, Nagoya City Univ.) "A Targeted Library of Small-Molecule, Tyrosine, and Dual-Specificity Phosphatase Inhibitors Derived from a Ratinal Core Design and Random Side Chain Variation" 15) 11:35-12:00 Dr. Paul Doyle (BioFocus) "Improving the Efficiency of Lead Optimisation" 16) 12:00-12:25 Manabu Hori and Kim Janda (Kanebo, Scripps Res.) "Synthesis and Purification of beta-Amino Alcohol Using "Fish Out" Method" (Lunch) (Vendor Demonstration) 17) 14:00-14:50 Dr. Junichi Yoshida "Prospects for Automated Synthesis" 18) 14:50-15:40 Dr. Robert Brown (Molecular Simularions Inc.) "Rational Design of Combinatorial Libraries" 19) 15:40-16:30 Dr. Daniel B. Kassel (CombiChem, Inc.) "Mass Spectrometric-Based Strategies for Characterizing and Purifying Combinatorial Libraries-Developments of a Multi-Column HPLC/MS System" 20) 16:30-17:20 Dr. Michael Kahn (Univ. of Washington) "Biased Secondary Structure Mimetic Libraries for Pharmaceutical Development" 21) 17:30- Closing Remarks For details, please see the JCCF homepage. The URL is http://www.orgsyn.riken.go.jp/CombiChem.html. FAX:+81(Japan)-6-871-8278 Email: jccf@yo.rim.or.jp \ / _ / / Yoshihisa INOUE, Yoshitomi Pharcaceut.Ind., Ltd. \ / / / / 2-25-1 Shodai-Ohtani,Hirakata,Osaka 573-1153 JAPAN / ____/ / tel: +81-720-56-9328 / / / fax: +81-720-68-9597 _/ __/ __/ E-mail: inoue@greencross.co.jp From owner-repertoires@net.bio.net Sun Apr 19 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Wendy Warr Newsgroups: bionet.molecules.repertoires Subject: Conference announcement Date: 20 Apr 1998 02:27:39 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 41 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6hf3u0$9el@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Subject: ChemInt'98 ChemInt'98 - Chemistry and the Internet - will be held in Irvine, CA on September 12-15, 1998. Technical Sponsors: ACS CINF Division ACS COMP Division The Chemical Structure Association (CSA) Special Libraries Association (SLA) Chemistry Division Current list of accepted speakers: Wendy Warr, Wendy Warr & Associates Barry Hardy, VEI Matt Hahn, MSI Mark J. Winter, University of Sheffield Henry Rzepa, Imperial College, London Joost Kircz, Elsevier Science, The Netherlands Peter Murray Rust, University of Nottingham Dave Weininger, Daylight Chemical Information Systems Nestor J. Zaluzec, Argonne National Labs This conference will look into the current and future technologies and developments for chemistry using the internet. This meeting will gather together the leaders and innovators in developing Internet resources for chemists, leading to discussions of what future innovations and direction will bring to chemists. Chemists who use the Internet on a regular basis, webmasters and web developers for chemistry sites, and web publishers will benefit greatly from this conference. In addition, working chemists who want to learn from leaders in this high growth and high visibility area what the current and future value of the Internet will also find the conference of great value. For details, please look at the url: http://www.ijc.com/ci1/ From owner-repertoires@net.bio.net Sun Apr 19 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Matthias Engel Newsgroups: bionet.molecules.repertoires Subject: phage display cDNA library Date: 20 Apr 1998 02:25:36 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 21 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6hf3jc$96q@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net I have read your posting in the molbio.methods newsgroup on the phage display cDNA library system from Clontech. I have found out that this system is originally produced by Maximbiotech. I have bought one of the libraries from this company to isolate an interacting partner for my target protein. I could not isolate something useful. So far, I have only found Maximbiotech as a commercial source for phage display cDNA libraries (Clontech has stopped to sell them). Now my question: do you know another source - either commercial or non-commercial? I intend to use it only for non-profit research purposes. I would greatly appreciate if you could help me. Your sincerely, Matthias Engel From owner-repertoires@net.bio.net Mon Apr 20 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Matthias Engel Newsgroups: bionet.molecules.repertoires Subject: More about cDNA phage display libraries Date: 21 Apr 1998 01:59:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 32 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6hfseq$9g5@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Colleagues, thanks a lot for answer. For your benefit I will provide you with a short summary of other answers I have got from different colleagues: Nobody so far had knowledge of a commercial source for phage display cDNA libraries (except the one I used), however, Andrew Bradbury wrote that there may come something in the future from Invitrogen. The latter system will be an (hopefully) improved version of the pJuFo system which is based on the pCOMB vector. Most answers I have got were in favour of the pJuFo system developed by Mark Suter, which has overcome the problem of stop codons in the cDNA. However, this system is not perfect either: the pCOMB vector is said to be prone to deletion and rearrangement. Moreover, Liselotte Kahns wrote that she had no success in isolating clones against some defined ligands using a cDNA library from a human melanoma cell line that she had subcloned into the pJuFo vector. Furthermore, H-Ras could not be correctly displayed on pJuFo. L. Kahns suggested that the synthetically engineered cystein residues of the pJuFo may interfere with correct folding of the cDNA products by making wrong disulfide bonds. Regarding the phage display library from Maximbiotech that I have used, I have got one answer from Alfredo Nicosia, who has obtained the same negative results using a human brain cDNA library (I have used a human breast cDNA library). I did not here about any successful screening with this type of libraries. Hope this information is useful for you. Best wishes, Matthias From owner-repertoires@net.bio.net Tue Apr 21 23:00:00 1998 Path: biosci!biosci!not-for-mail From: corniche information Newsgroups: bionet.molecules.repertoires Subject: nuclear reporter gene Date: 22 Apr 1998 01:46:32 -0700 Organization: BT Internet Lines: 25 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <353CB768.DF96A559@corniche.com> NNTP-Posting-Host: net.bio.net We were contacted recently with the following request which we are unable to fulfill:- ....................................................................... Hi, I am studying cis-regulation of a gene encoding nuclear protein. I am using beta-gal to show the expression pattern of this gene. But the result is not so good because beta-gal is expressed in cytoplasm, not nuclearly. Do you know any nuclear reporter gene I can use? Thank you very much! Zhe Han zhan@umich.edu ...................................................................... If you are able to help please contact Zhe directly. Corniche.. the On-line life science resource. Free to use searchable database conatining 50,000 products from many sources large and small. http://www.corniche.com From owner-repertoires@net.bio.net Wed Apr 22 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "M. Dekker" Newsgroups: bionet.molecules.repertoires Subject: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING Date: 23 Apr 1998 05:09:12 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 41 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6hn9qv$36s@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Announcing : THE JOURNAL TO REVOLUTIONIZE DRUG DISCOVERY Dear Colleague, The first issue of the exciting new journal is now out: "COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING" http://www.bscipubl.demon.co.uk/cchts For subscription information, free sample copy request, list of papers, editorial scope etc. please see the journal Web Site. You may order your FREE sample copy of the journal by contacting, Mrs. S. Hidding, Journal Department, Bentham Science Publishers at the following e-mail address: shidding@worldonline.nl or FAX at: +1 305-596-5120 or +31 35-698-0150 Best regards, Editor-in-Chief : Dr. Richard B. van Breemen Department of Medicinal Chemistry and Pharmacognosy University of Illinois at Chicago 833 South Wood Street (M/C 781) Chicago, IL 60612-7231 USA Fax: +1 312 996 7107 email: Richard.vanBreemen@uic.edu From owner-repertoires@net.bio.net Thu Apr 23 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "M. Dekker" Newsgroups: bionet.molecules.repertoires Subject: CURRENT MEDICINAL CHEMISTRY Date: 24 Apr 1998 04:04:50 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 35 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6hpqu7$lef@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Announcing : CURRENT MEDICINAL CHEMISTRY - The Leading Journal for Timely In-Depth Reviews in Medicinal Chemistry Dear Colleague, Order your FREE sample copy today of: "CURRENT MEDICINAL CHEMISTRY" http://www.bscipubl.demon.co.uk/cmc For subscription information, free sample copy request, list of papers, editorial scope etc. please see the journal Web Site. You may order your FREE sample copy of the journal by contacting, Mrs. S. Hidding, Journal Department, Bentham Science Publishers at the following e-mail address: shidding@worldonline.nl or FAX at: +1 305-596-5120 or +31 35-698-0150 Best regards, Mark Dekker, Ph.D. Editorial Director Bentham Science Publishers Inc. E-mail: M.Bentham@inter.NL.net http://www.bscipubl.demon.co.uk From owner-repertoires@net.bio.net Tue Apr 28 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Bernd Degen Newsgroups: bionet.molecules.repertoires Subject: Analysis programme CoTrix Date: 29 Apr 1998 09:46:30 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 48 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6i51cg$1mq@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear colleagues! Do you use molecular gene markers? And do you know the inheritance of your gene markers? For many population genetic applications a codominant mode of inheritance is indispensable (e.g. estimation of genetic diversity, observed heterozygosity, genetic differentiation). But how to perform an inheritance analysis on complex DNA banding patterns? Especially for that purpose we developed the computer analysis programme CoTrix. A new 32 bit version of the programme is now available in the subdirectory SOFTWARE of our homepage for free download: http://www.rrz.uni-hamburg.de/OekoGenetik/welcome.htm See also short description below. _______________________________________________________________ CoTrix is an interactive user-friendly computer programme for analysis of complex DNA banding patterns. The windows programme was developed for the following tasks: a.. Band adjustment for experimentally caused migration differences in pherogrammes b.. Transformation of banding patterns into 1/0 matrix c.. Inheritance analysis =3D> search for codominant (dominant) inherited DNA- fragments d.. Calculation of distances (Tanimoto) between individual banding patterns ******************************************************************** Dr. Bernd Degen Institute for Forest Genetics and Forest Tree Breeding Sieker Landstrasse 2 D-22927 Germany Tel.: +49-4102-696-160 Fax.:+49-4102-696-200 http://www.uni-hamburg..de/OekoGenetik/welcome.htm ******************************************************************** From owner-repertoires@net.bio.net Thu Apr 30 23:00:00 1998 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 1 May 1998 04:47:01 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199804280900.CAA13965@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms.