From owner-repertoires@net.bio.net Mon May 04 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Shu-Kun Lin Newsgroups: bionet.molecules.repertoires Subject: The 26th monthly release of MDPI samples Date: 5 May 1998 04:16:51 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 40 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6imohk$617@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Colleagues, We have just uploaded the 26th monthly release of MDPI available samples for April 1998. There are 226 compounds. They can be downloaded from website http://www.mdpi.org/database.htm#new For obtaining the MDPI samples free of charge for academic research use or at low prices for companies, please visit http://www.mdpi.org/ or http://www.unibas.ch/mdpi/ websites for further information. We plan to send diskette of the database of MDPI available samples upon your request. If you are interested in receiving the diskette, please tell us your full mailing address by e-mail or by fax. Sincerely, Shu-Kun Lin President of MDPI --------------------------------------------------------- Dr. Shu-Kun Lin Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland http://www.mdpi.org/ MOLECULES http://www.mdpi.org/molecules/ ECSOC-2 http://www.mdpi.org/ecsoc-2.htm E-mail lin@mdpi.org Tel. +41 79 322 3379, Fax +41 61 302 8918 -------------------------------------------------------- From owner-repertoires@net.bio.net Tue May 05 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "M. Dekker" Newsgroups: bionet.molecules.repertoires Subject: Re: CURRENT PHARMACEUTICAL DESIGN Date: 6 May 1998 05:37:59 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 49 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6ipkbp$huf@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net DISPATCHES FROM THE FRONT LINE OF DRUG DESIGN !! Announcing : CURRENT PHARMACEUTICAL DESIGN - The Leading Journal for Timely In-Depth Reviews in Topics in Drug Design. Dear Colleague, Order your FREE sample copy today of: CURRENT PHARMACEUTICAL DESIGN http://www.bscipubl.demon.co.uk/cpd Issues & Editors: Anti-Cancer Agents - A.P. Kozikowski (Georgetown University, WA, USA) Anti-Infective Agents - D.T.W. Chu (Abbott Laboratories, IL, USA) Cardiovascular & Hematological Agents - A.M. Doherty & J.M. Hamby (Parke-davis Pharmaceutical Research, MI, USA) Central Nervous System Agents - G. Johnson (Bristol-Myers Squibb, CT, USA) Immunology, Endocrine and Metabolic Agents- D.R. Sliskovic (Parke-Davis Pharmaceutical Research, MI, USA) Anti-Inflammatory and Anti-Allergy Agents - S.W. Djuric (Abbott Laboratories, IL, USA) For subscription information, free sample copy request, list of papers, editorial scope etc. please see the journal Web Site. You may order your FREE sample copy of the journal by contacting, Mrs. S. Hidding, Journal Department, Bentham Science Publishers at the following e-mail address: shidding@worldonline.nl or FAX at: +1 305-596-5120 or +31 35-698-0150 Best regards, Mark Dekker, Ph.D. Editorial Director Bentham Science Publishers Inc. E-mail: M.Bentham@inter.NL.net http://www.bscipubl.demon.co.uk From owner-repertoires@net.bio.net Tue May 05 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Peter Nestler, Cold Spring Harbor" Newsgroups: bionet.molecules.repertoires Subject: Glass Beads Date: 6 May 1998 05:37:02 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6imoii$612@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Hello to everyone - I am looking for controlled pore glass beads that I could use for the synthesis of split-mix libraries. The bead size should be around 50-100 micron in diameter with 75 Angstroem pores and carry aminofunctionalities (if possible). Currently I am working with beads from Sigma but they are fairly irregular in shape and size. Does anybody know any source for glass beads that are spherical and homogeneous in size? Thanks for your help. Peter Nestler --------------------------------------------------------------- Dr. H. Peter Nestler (nestler@cshl.org) Cold Spring Harbor Laboratory One Bungtown Road Cold Spring Harbor, NY 11724 (USA) Voice: (516) 367-8822; Fax: (516) 367-8873 http://www.cshl.org/labs/nestler/ --------------------------------------------------------------- From owner-repertoires@net.bio.net Sun May 17 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Luc Van Hijfte Newsgroups: bionet.molecules.repertoires Subject: Job offers Synthelabo Biomolecular, Strasbourg, France Date: 18 May 1998 08:20:52 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 56 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6jp8ar$f44@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net Synthelabo Biomolecular, the center of new drug discovery technologies for Synthelabo is seeking highly qualified research scientists for its combinatorial chemistry department. Synthelabo Biomolecular, located in Strasbourg, offers a multinational, multidisciplinary and dynamic environment for researchers interested in high throughput lead generation and optimisation. RESEARCH SCIENTIST - SPECIAL LIBRARIES AND RESYNTHESIS GROUP The individual will evaluate and perform solution and solid phase syntheses for library production around interesting and original scaffolds. Responsibilities will include involvement from initial stages of chemical development through library production and hit-resynthesis. A Ph.D. in organic chemistry with 2-5 years of experience, preferably in combinatorial synthesis related to medicinal targets, is required. RESEARCH SCIENTIST/ENGINEER - HIGH THROUGHPUT SYNTHESIS GROUP The candidate will play a crucial role in the implementation, maintenance and possibly design of instruments related to automated chemical synthesis, and will also be involved in the chemical development and production of combinatorial chemistry libraries. The successful candidate will have a Ph.D. and/or engineer diploma in organic chemistry with 2-5 years of industrial experience, preferably in the area of chemistry automation. A working knowledge of liquid handling robots, state of the art organic chemistry skills and programming experience are essential. Both candidates should have demonstrated effective organizational and communication skills, and be able to perform strongly in a team environment. Knowledge of the French language may be helpful, but is not essential. Please send your resume to : Synthelabo Biomolecular Ressources Humaines 16, rue d'Ankara 67080 Strasbourg cedex France ########################################### Luc Van Hijfte Department head, Combinatorial Chemistry Synthelabo Biomoleculaire 16 rue d'Ankara 67080 Strasbourg Phone : 0388608758 Fax : 0388459075 ########################################### From owner-repertoires@net.bio.net Sun May 17 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "M. Dekker" Newsgroups: bionet.molecules.repertoires Subject: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING Date: 18 May 1998 08:18:52 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 43 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6jp87f$f0v@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net DO NOT MISS READING THIS ANNOUNCEMENT ! Dear Colleague, The first issue of the exciting new journal is now out: "COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING" http://www.bscipubl.demon.co.uk/cchts For subscription information, free sample copy request, list of papers, editorial scope etc. please see the journal Web Site. You may order your FREE sample copy of the journal by contacting, Mrs. S. Hidding, Journal Department, Bentham Science Publishers at the following e-mail address: shidding@worldonline.nl or FAX at: +1 305-596-5120 or +31 35-698-0150 Best regards, Editor-in-Chief : Dr. Richard B. van Breemen Department of Medicinal Chemistry and Pharmacognosy University of Illinois at Chicago 833 South Wood Street (M/C 781) Chicago, IL 60612-7231 USA Fax: +1 312 996 7107 email: Richard.vanBreemen@uic.edu From owner-repertoires@net.bio.net Mon May 25 23:00:00 1998 Path: biosci!biosci!not-for-mail From: nicoleta@u.arizona.edu Newsgroups: bionet.molecules.repertoires Subject: phage display-plastic binders Date: 26 May 1998 01:42:04 -0700 Organization: univ of arizona Lines: 27 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6ka8g1$fbi$1@news.ccit.arizona.edu> NNTP-Posting-Host: net.bio.net Hi everybody! I have isolated a bunch of phages which expose peptides very rich in histidine with no apparent consensus. I have read about plastic binding peptides (Gene 156 (1995): 27-31), and could not decide if my peptides are plastic binders or not. Looks like plastic binders are rich in W and Y. Has anybody encountered this group of peptides very rich in HISTIDINE? Here's an example of what I mean: KPSHHHHHTQAN HFKHHFHSARAS MHKHHHMPRTSA SIYHRHHHPRVL... and the list goes on. I am in the process of doing the control experiments to confirm the specificity of these peptides, but I would like to know from other people's experience, too, before I put too much time and money in isolating plastic binders!!! Thanks, Nicoleta From owner-repertoires@net.bio.net Thu May 28 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Shu-Kun Lin Newsgroups: bionet.molecules.repertoires Subject: The 27th monthly release of MDPI samples Date: 29 May 1998 07:07:47 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 39 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Dear Colleagues, he 27th monthly release of MDPI available samples for May 1998 was just uploaded. There are 254 compounds. The database files can be downloaded from website http://www.mdpi.org/database.htm#new For obtaining the MDPI samples free of charge for academic research use or at low prices for companies, please visit http://www.mdpi.org/ or http://www.unibas.ch/mdpi/ websites for further information. We sent diskette of the database of available samples upon your request. If you are interested in the diskette, please tell us your full mailing address by e-mail or by fax. (If you would like to be removed from this mailing list, please let me know.) Sincerely, Shu-Kun Lin --------------------------------------------------------- Dr. Shu-Kun Lin Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland http://www.mdpi.org/ MOLECULES http://www.mdpi.org/molecules/ ECSOC-2 http://www.mdpi.org/ecsoc-2.htm E-mail lin@mdpi.org Tel. +41 79 322 3379, Fax +41 61 302 8918 -------------------------------------------------------- From owner-repertoires@net.bio.net Thu May 28 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Cynthia S. Smagula" Newsgroups: bionet.molecules.repertoires Subject: 100 New Tools Added to BioToolKit Date: 29 May 1998 04:25:11 -0700 Organization: BIOTA Publications Lines: 32 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <356D4F15.65DC@onramp.net> Reply-To: biota@onramp.net NNTP-Posting-Host: net.bio.net The BioToolKit, an annotated directory of over 600 online molecular biology resources (at http://www.biosupplynet.com) has recently added links to many new resources, including: ACUTS (Ancient Conserved Untranslated Sequences) dbCFC (Cytokine Family database) DNA Patent Database CD Guides (cell surface markers) MAR-Finder (Matrix Attachment Regions) In Situ PCR on Plant Material Vacuum Infiltration Transformation of Arabidopsis PPMdb (Plant Plasma Membrane database) MitBASE (comprehensive mitochondrial database) GenProtEC (E.coli gene relationships) The Interactive Fly WormPep (predicted proteins in C.elegans) WebMolecules VRML Player (analyzes your system, suggests viewers) 3-D Crunch (SWISS-MODEL predicts 50,000 structures) Atlas of Protein Topology Cartoons (simple 2-D diagrams) Movies of Protein Motions Protein Morphing Server PROMISE: Prosthetic Groups and Metal Ions in Protein Active Sites ADOPS: Associative Database of Protein Sequences NeuronDB Complete descriptions of these sites and links are found at http://www.biosupplynet.com, just click on the BioToolKit. The BioToolKit database is designed for rapid page delivery, functionally organized, and Verity-searchable. From owner-repertoires@net.bio.net Sun May 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "M. Dekker" Newsgroups: bionet.molecules.repertoires Subject: CURRENT MEDICINAL CHEMISTRY Date: 1 Jun 1998 02:43:53 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 40 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net DO NOT MISS READING THIS ANNOUNCEMENT ! Announcing : CURRENT MEDICINAL CHEMISTRY - The Leading Journal for Timely In-Depth Reviews in Medicinal Chemistry Dear Colleague, Order your FREE sample copy today of: "CURRENT MEDICINAL CHEMISTRY" http://www.bscipubl.demon.co.uk/cmc For subscription information, free sample copy request, list of papers, editorial scope etc. please see the journal Web Site. You may order your FREE sample copy of the journal by contacting, Mrs. S. Hidding, Journal Department, Bentham Science Publishers at the following e-mail address: shidding@worldonline.nl or FAX at: +1 305-596-5120 or +31 35-698-0150 Best regards, Mark Dekker, Ph.D. Editorial Director Bentham Science Publishers Inc. E-mail: M.Bentham@inter.NL.net http://www.bscipubl.demon.co.uk From owner-repertoires@net.bio.net Sun May 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Amy L. Dasch" Newsgroups: bionet.molecules.repertoires Subject: Conference in Zurich Date: 1 Jun 1998 03:18:33 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 25 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net I am currently organizing a conference on molecular diversity, combinatorial chemistry, high through-put screening as well as chemoinformatics. I am looking for researchers that hail from European based laboratories that can talk about how they use informatics for drug discovery. I am also interested in finding scientists who can discuss the issues of diversity within a combinatorial library. I would like to avoid discussions which are commercial in nature. If you are interested in presenting, the conference will be October 8-9 of this year in Zurich. I need a title and 5-6 sentence description by this Friday, May 29. Thank you for your consideration. Amy Dasch Conference Director Cambridge Healthtech Institute 1037 Chestnut Street Newton, MA 02164 (617)-630-1352 Phone (617)-630-1325 FAX adasch@healthtech.com From owner-repertoires@net.bio.net Sun May 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "M. Dekker" Newsgroups: bionet.molecules.repertoires Subject: CURRENT PHARMACEUTICAL DESIGN Date: 1 Jun 1998 03:15:48 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 52 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net DO NOT MISS READING THIS ANNOUNCEMENT ! Announcing : CURRENT PHARMACEUTICAL DESIGN - The Leading Journal for Timely In-Depth Reviews in Topics in Drug Design. Dear Colleague, Order your FREE sample copy today of: CURRENT PHARMACEUTICAL DESIGN http://www.bscipubl.demon.co.uk/cpd Issues & Editors: Anti-Cancer Agents - A.P. Kozikowski (Georgetown University, WA, USA) Anti-Infective Agents - D.T.W. Chu (Abbott Laboratories, IL, USA) Cardiovascular & Hematological Agents - A.M. Doherty & J.M. Hamby (Parke-davis Pharmaceutical Research, MI, USA) Central Nervous System Agents - G. Johnson (Bristol-Myers Squibb, CT, USA) Immunology, Endocrine and Metabolic Agents- D.R. Sliskovic (Parke-Davis Pharmaceutical Research, MI, USA) Anti-Inflammatory and Anti-Allergy Agents - S.W. Djuric (Abbott Laboratories, IL, USA) For subscription information, free sample copy request, list of papers, editorial scope etc. please see the journal Web Site. You may order your FREE sample copy of the journal by contacting, Mrs. S. Hidding, Journal Department, Bentham Science Publishers at the following e-mail address: shidding@worldonline.nl or FAX at: +1 305-596-5120 or +31 35-698-0150 Best regards, Mark Dekker, Ph.D. Editorial Director Bentham Science Publishers Inc. E-mail: M.Bentham@inter.NL.net http://www.bscipubl.demon.co.uk From owner-repertoires@net.bio.net Sun May 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 1 Jun 1998 02:45:04 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199805280900.CAA08629@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-repertoires@net.bio.net Sun May 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Lynn Caporale Newsgroups: bionet.molecules.repertoires Subject: Molecular Stategies in biological evolution Date: 1 Jun 1998 03:23:30 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 16 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net I would like to draw your attention to the agenda of a meeting, entitled "Molecular Strategies in Biological Evolution", to be held at Rockefeller University June 27-29, and would appreciate it if you could share this information with others whom you think might find it of interest. Please note that there may be some fellowship $$ available. The URL is at: http://www.nyas.org/brochmsb.html Thank you, Lynn Caporale From owner-repertoires@net.bio.net Sun May 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Guy Salvesen Newsgroups: bionet.molecules.repertoires Subject: post-doc positions available Date: 1 Jun 1998 03:22:01 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 35 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Two post-doctoral positions are available, starting July-November 1998, to study aspects of proteolysis and its regulation in apoptosis. Research will be carried out at the Burnham Institute in La Jolla, California (http://www.burnham-inst.org) in the lab of Guy Salvesen (http://www.burnham-inst.org/reports/7.Salvesen.97.1.html). Project 1. Mechanistic studies on the IAP family of natural protease inhibitors targeting the caspases (see Nature 388, 300-304). Project 2. The role of proteolytic enzymes in neuronal apoptosis, including studies on caspase activation (see Cell 91, 443-0446). Applicants should have, or expect, a doctoral degree in a Biological Science or Chemistry. Both projects require candidates with an interest, and preferably experience, in protein biochemistry or enzymology, and project 2 will additionally involve some cell biology. All applicants should have experience with basic recombinant DNA techniques. To apply, please forward your CV, including list of publications and a brief statement of research interests, together with the names of two referees, to the address below. ____________________________________________________________ Guy Salvesen Ph.D. gsalvesen@ljcrf.edu Burnham Institute Fax - (619)646-3199 10901 N. Torrey Pines Road La Jolla, CA 92037