From owner-repertoires@net.bio.net Sun Aug 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: c_cardozo@SMTPLINK.MSSM.EDU Newsgroups: bionet.molecules.repertoires Subject: Postdoctoral Position Date: 3 Aug 1998 02:08:13 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 12 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Postdoctoral Position is lable in the laboratory of Dr. Marian Orlowski. The project involves study of the enzymology of the 26S proteasome and PA28-20S proteasome complexes. The position is funded for 3 years by the National Institutes of Health. From owner-repertoires@net.bio.net Sun Aug 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 3 Aug 1998 02:06:50 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199807280900.CAA19976@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-repertoires@net.bio.net Sun Aug 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: MICHAEL KEENAN Newsgroups: bionet.molecules.repertoires Subject: Combinatorial Chemistry Conference Date: 3 Aug 1998 02:15:53 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 16 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Announcing: IBC's International Conference on Integrating Combinatorial Chemistry into the Discovery Pipeline September 14-15, 1998 Doubletree Hotel National Airport Arlington, Virginia Full conference brochure and registration information on line: http://www.ibcusa.com/conf/combinatorial. Please feel free to email me at mkeenan@ibcusa.com with any questions Michael Keenan IBC USA Conferences From owner-repertoires@net.bio.net Sun Aug 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Z.G. Zhao" Newsgroups: bionet.molecules.repertoires Subject: post-doc positions (fwd) Date: 3 Aug 1998 02:12:45 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 68 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Two post-doctoral positions, involving "one-bead one-compound combinatorial library method", are now opened in Dr. Kit S. Lam's Laboratory at the Arizona Cancer Center, Tucson, Arizona. For those who are interested, please contact Dr. Lam at klam@azcc.arizona.edu, or fax the CV to (520)626-6292. First position: Position Summary: The successful candidate will be responsible for the development of novel high-throughput screening methods for the "one-bead one-compound" combinatorial libraries. Candidate will apply these assay methods to screen various combinatorial libraries. The identified leads will then be fully characterized biologically and biochemically. Areas of research include novel protein phosphorylation, protein-protein interaction, and signal transduction pathways in cancer cells. Preferred Qualifications: Expertise in protein biochemistry and assay development Experience in tissue culture methods Working experience with radionuclides Familiarity with peptide chemistry Strong computer and organizational skills Ability to work independently to address the unique difficulties and limitations presented by a developing technology Minimum Qualifications: Ph.D. in Biochemistry, Pharmacology, or related field. Extensive experience in protein biochemistry and assay development Second Position: Position Summary: The successful candidate will continue the development of the "one-bead one-compound" combinatorial peptide and small molecule libraries. Duties and responsibilities include: (1) development of new chemistries for combinatorial library synthesis, (2) development of new linkers, (3) development and synthesis of constrained peptide libraries, (4) development and synthesize small molecule chemical libraries, and (5) development and synthesis of organic molecules. The candidate will become a critical member of a drug development team, and also work closely with the biologists in tackling fundamental chemical-biology questions. Areas of research include cancer and infectious disease. Preferred Qualifications: Expertise in organic synthesis and peptide chemistry Experience in combinatorial chemistry Working knowledge of computational chemistry Strong computer and organizational skill Ability to work independently to address the unique difficulties and limitations presented by a developing technology Minimum Qualifications: Ph.D. in Chemistry Expertise in Organic Synthesis From owner-repertoires@net.bio.net Sun Aug 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Bob Diegelmann Newsgroups: bionet.molecules.repertoires Subject: Postdoctoral position in Tissue Repair Date: 3 Aug 1998 02:10:52 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 54 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net THE LABORATORY OF TISSUE REPAIR The Laboratory of Tissue Repair at the Medical College of Virginia of Virginia Commonwealth University has been awarded a Postdoctoral Training Grant from the National Institutes of Health. The purpose of this Training Program is to provide two years of research experience for postdoctoral fellows in the area of Tissue Repair. The Laboratory has over 25 years of experience in the field of wound healing and has trained a large number of residents who have been successful in obtaining fellowships in the area of Pediatric Surgery and Plastic Surgery. Currently the Laboratory has over 4,000 square feet of modern bench space with fully equipped tissue culture facilities, biochemical equipment and molecular biology facilities. The research focus of the Laboratory has expanded recently and now includes research opportunities in the fields of intestinal and liver fibrosis, vascular hyperplasia chronic ulcers and fetal tissue repair. Fellows will receive extensive training in techniques needed for isolating and maintaining cells in culture, biochemical and enzymatic techniques for analyzing collagen metabolism and state of the art molecular biology technologies. Cources include Scientific Integrity, Cell and Molecular Biology, Molecular Genetics, Current Trends in Biochemistry and Biostatistics. This Training Program is open to all candidates holding M.D., M.D./Ph..D.and Ph.D. Degrees. Applicants holding M.D. degrees are expected to have completed at least two years of residency training in a program approved by the ACGME and should be dedicated to a career in academic research. Applicants must be a U.S. Citizen or a non-citizen national of the U.S. or must be lawfully admitted for permanent residence. Individuals on temporary or student visas are not eligible. Members of minority groups will be given special consideration. To apply or for further information contact: Robert F. Diegelmann, Ph.D. Professor of Biochemistry, Molecular Biophysics and Surgery Medical College of Virginia Campus Virginia Commonwealth University 1101 E. Marshall Street Sanger Hall, Rm 3-036 Richmond VA, 23298-0117 804-828-9677 804-828-2621 (fax ) http://www.surgery.vcu.edu/plas-rfd.htm rdiegelm@hsc.vcu.edu From owner-repertoires@net.bio.net Sun Aug 02 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Douglas Tollefsen Newsgroups: bionet.molecules.repertoires Subject: postdoctoral position available Date: 3 Aug 1998 02:28:53 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 61 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net POSTDOCTORAL FELLOWSHIP We are seeking a postdoctoral fellow with experience in biochemistry and/or molecular biology to study the regulation of thrombin by serpins. The major emphasis of our laboratory has been to elucidate the mechanism of action of heparin cofactor II (HCII). Inhibition occurs when thrombin attacks the reactive site peptide bond in HCII leading to formation of a stable complex between the two proteins. Heparan sulfate and dermatan sulfate on the surface of fibroblasts and certain other cells bind HCII and increase the rate of thrombin inhibition >1000-fold. This process may determine the site of action of HCII in vivo. Specific oligosaccharide sequences in dermatan sulfate chains are required to stimulate HCII. We are determining the structures of these oligosaccharides using a variety of chemical and enzymatic techniques. In addition, we are investigating the protease- and oligosaccharide-binding domains of HCII by analysis of natural point mutations in the HCII gene, by site-directed mutagenesis of the cDNA, and by computer-assisted modelling. Immunohistochemical methods and targeted gene disruption are being developed to investigate the physiology of HCII in the mouse. Recent publications: Colwell, N.S., Tollefsen, D.M. and Blinder, M.A. Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder. Br. J. Haematol. 97: 219-226 (1997). Han, J.-H., Van Deerlin, V.M.D. and Tollefsen, D.M. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J. Biol. Chem. 272: 8243-8249 (1997). Han, J.-H., C=F4t=E9, H.F.C., and Tollefsen, D.M. Inhibition of meizothrombin and meizothrombin(desF1) by heparin cofactor II. J. Biol. Chem. 272: 28660-28665 (1997). Han, J.-H., and Tollefsen, D.M. Ligand binding to thrombin exosite II induces dissociation of the thrombin-heparin cofactor II(L444R) complex. Biochemistry 37: 3203-3209 (1998). Pavo MSG, Aiello KRM, Werneck CC, Silva LCF, Valente A-P, Mulloy B, Colwell NS, Tollefsen DM, Mouro PAS. Highly sulfated dermatan sulfates from ascidians: structure versus anticoagulant activity of these glycosaminoglycans. J. Biol. Chem., in press. For more information, please contact: Douglas M. Tollefsen, MD, PhD Hematology Division - Box 8125 Washington University Medical School 660 South Euclid Avenue St. Louis, MO 63110 tel: (314) 362-8830 fax: (314) 362-8826 email: tollefsen@im.wustl.edu From owner-repertoires@net.bio.net Thu Aug 06 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Yoshihisa Inoue Newsgroups: bionet.molecules.repertoires Subject: The 7th Meeting of Japan Combinatorial Chemistry Focus Group Date: 7 Aug 1998 07:19:00 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 96 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199808071108.UAA20463@terra.yoshitomi.co.jp> NNTP-Posting-Host: net.bio.net Dear Netters, We are pleased to announce that Japan Combinatorial Focus Group, JCCF, will hold the 7th JCCF Meeting on September 8-9 at Kanagawa Science Park near Tokyo, Japan. And we have to say sorry that if you want to present your products at the booths, all the 30 booths are occupied already. Please try next meeting in Osaka in April. **************************************************************** 7th Meeting of Japan Combinatorial Chemistry Focus Group **************************************************************** Program (tentative) of JCCF7 **************************************************************** [Sept. 8, 1998] 09:50-10:00 <> Takashi Takahashi, Chairman of JCCF7 10:00-10:50 IL-01 Accelerated Lead Discovery by Automated Parallel Synthesis (ArQule, Inc.) Paul R. Fleming 10:50-11:40 IL-02 Importance of optimizing pharmacokinetic properties in the new drug development:Highthroughput screening of drug metabolism and transport characteristics (University of Tokyo) Yuichi Sugiyama 11:40-12:05 SP-01 A Solid Phase Approach to the Quinolone Antibiotics (Aroganout Technologies) Alasdair MacDonald 12:05-14:00 <> 14:00-14:50 IL-03 Combinatorial Synthesis of Inorganic Thin Films and Devices (Tokyo Institute of Technology) H. Koinuma *, Y. Matsumoto, M. Kawasaki, T. Fukumura, T. Ohnishi, M. Lippmaa 14:50-15:15 SP-02 Synthetic Strategy Toward Combinatorial Chemistry: Mizoroki-Heck Reaction and One-Pot Sequential Asymmetric Hydrogenation (Tokyo Institute of Technology) Takashi Takahashi, Takayuki Doi* 15:15-15:40 SP-03 Development of A Versatile Linker for NH in Solid Phase Synthesis (Fujisawa Pharmaceutical Co., Ltd.,) Akito Tanaka,* Hideo Tsutsumi 15:40-16:05 SP-04 Library Synthesis and Scale up using the Directed Sorting technology (IRORI) Aubrey J. Mendonca 16:05-16:30 SP-05 High-throughput Modular System for Generating and Screening Compound Libraries (Robbins Scientific) David W. Batey 16:30-17:20 IL-04 Solution-phase Combinatorial Chemistry: Scope and Applications (The Scripps Research Institute) Dale Boger 18:00-19:30 beer party [Sept. 9, 1998] 09:30-10:20 IL-05 New Chemoselective Solid Phase Metalation (Tohoku University) Yoshinori Kondo 10:20-11:10 IL-06 SELDI (Surface Enhanced Laser Desorption/Ionization) Protein Chip Technology with Mass Spec. for Proteomics (Ciphergen Biosystems Inc.) William Hutchens 11:10-11:35 SP-06 Combinatorial Chemistry - Development and application of solid supports (Calbiochem-Novabiochem) Barbara Doerner 11:35-12:00 SP-07 Important Recent Advances in a Combinatorial Chemistry Technology Platform and Associated Informatics (Cambridge Combinatorial) Dave Tapolczay 12:00-14:00 <> 14:00-14:50 IL-07 Polymer-Supported Carbohydrate Libraries (Princeton Univ.) Daniel Kahne 14:50-15:40 IL-08 A New Approach to Molecular Design Based on Biomolecular Recognition Technology - Application of Phage Peptide Library - (Otsuka Pharmaceutical Co., Ltd.) Takao Taki 15:40-16:05 SP-08 Application of HRMAS Spectroscopy and BEST-NMR Method to Combinatorial Chemistry (Bruker Japan) Hajime Sato 16:05-16:30 SP-09 Development of Focused Library of Serine Proteases (Molecumetics) Michael Kahn, Hiroshi Nakanishi, Takeo Harada * 16:30-17:20 IL-09 Computational Approaches to Library Design for Lead Generation, Lead Evolution, and Lead Optimization (CombiChem) David Spellmeyer 17:20-17:30 <> Koichi Fukase, Chairman of JCCF8 For details, please see the JCCF homepage. The URL is http://www.orgsyn.riken.go.jp/CombiChem.html. FAX:+81(Japan)-6-871-8278 Email: jccf@yo.rim.or.jp \ / _ / / Yoshihisa INOUE, Yoshitomi Pharcaceut. Ind., Ltd. \ / / / / 2-25-1 Shodai-Ohtani,Hirakata,Osaka 573-1153 JAPAN / ____/ / tel: +81-720-56-9328 / / / fax: +81-720-68-9597 _/ __/ __/ E-mail: inouey@yoshitomi.co.jp From owner-repertoires@net.bio.net Thu Aug 06 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Z. G. Zhao" Newsgroups: bionet.molecules.repertoires Subject: Combinatorial Chemistry Conference Date: 7 Aug 1998 02:59:11 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 81 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Second International Conference on Combinatorial Library Methods For Basic Research and Drug Discovery January 10 - 12, 1999 Tucson, Arizona USA Conference Discription: Combinatorial libraries of components can now be generated using chemical, biosynthetic, or biological methods and probed for functional or molecular interactions with target macromolecules. This field is expanding rapidly in many areas of biomedical research. The goal of this conference is to survey the current status of the field and provide opportunities for new research presentations to a focused and interested audience. Conference Chairman: Kit S. Lam, M.D., Ph.D., Arizona Cancer Center Program Committee: Kevin Burgess, Ph.D. Brian K. Kay, Ph.D. Jack D. Keene, Ph.D. Michal Lebl, Ph.D., D.Sc. Invited Speakers John J. Baldwin, Ph.D., Pharmacopeia Ed Brody, Ph.D., NeXstar Pharmaceuticals, Inc. Kevin Burgess, Ph.D., Texas A & M University Sheila Hobbs DeWitt, Ph.D., Orchid Biocomputer Inc. Victor Hruby, Ph.D., University of Arizona Jon Ellman, Ph.D., University of California at Berkeley H. Mario Geysen, Ph.D., Glaxo Wellcome Brian K. Kay, Ph.D., University of Wisconsin at Madison Jack D. Keene, Ph.D., Duke University Medical Center John Krstenansky, Ph.D., EnzyMed, Inc. Irwin Kuntz, Ph.D., University of California at San Francisco Michal Lebl, Ph.D., D.Sc., Trega Biosciences, Inc. Robert S. Pearlman, Ph.D., University of Texas at Austin Richard Roberts, Ph.D., California Institute of Technology Erkki Ruoslhti, Ph.D., The Burnham Institute Sangyong Zhou, Ph.D., Baylor College of Medicine George Smith, Ph.D., University of Missouri at Tucker Peter Strop, Ph.D., Selectide Corporation Jill Winter, Ph.D., Chiron Corporation Peter Wipf, Ph.D., University of Pittsburgh Registration: Registration fee (U.S. dollars) before September 30, 1998: Commercial $400 Academic $250 Student and Post-Doctoral $125 with verification letter from advisor Registration fee (U.S. dollars) after September 30, 1998: Commercial $450 Academic $300 Student and Post-Doctoral $175 with verification letter from advisor A limited number of travel awards ($500) will be available for graduate students or post-doctoral fellows who present an abstract at the conference. For those who are interested, please accompany the abstract with a letter from your supervisor stating that you are a graduate student or post-doctoral fellow and that you will present the abstract if accepted. For conference schedule, hotel accommodation, airline ticket discount and other information about the conference, please check out the conference homepage at http://www.azcc.arizona.edu From owner-repertoires@net.bio.net Mon Aug 10 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Amy L. Dasch" Newsgroups: bionet.molecules.repertoires Subject: Identification of Novel Bioactive Compounds Date: 11 Aug 1998 02:03:24 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 102 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Cambridge Healthtech Institute Announces Second European Conference Strategies and Techniques for Identification of Novel Bioactive Compounds October 7-9, 1998 "Hotel Inter-Continental" Zurich, Switzerland Corporate Support Provided Jointly By: Cambridge Combinatorial Ltd. Cambridge Drug Discovery Ltd. Oxford Molecular Group plc Cosponsoring Journals Combinatorial Chemistry and High Throughput Screening published by Bentham Current Pharmaceutical Design published by Bentham Drugs of the Future published by Prous Molecules published by MDPI Scientific Advisory Committee Dr. Petr Kocis, Zeneca Pharmaceuticals Dr. Shu-Kun Lin, Molecular Diversity Preservation International (MDPI) Dr. Alisdair MacDonald, Argonaut Technologies, Inc. Dr. Pierfausto Seneci, GlaxoWellcome S.p.A. Speakers Dr. Jochen Antel, Solvay Pharma Dr. Anthony Baxter, Oxford Asymmetry International Prof. Mark Bradley, University of Southampton Dr. Ernst Burgisser, Discovery Technologies Ltd. Dr. Alain Calvet, Parke-Davis Pharmaceutical Research Dr. Patrick Coffey, Biotage Division of Dyax Corp. Dr. Ferenc Darvas, ComGenex, Inc. Dr. Sheila H. DeWitt, Orchid Biocomputer, Inc. Dr. Simon Fogarty, Cambridge Drug Discovery Ltd. Dr. Jonathan Frost, Synthelabo Recherche Dr. Steve Gallion, ArQule, Inc. Dr. C. John Harris, BioFocus plc Dr. Peter Hecht, Tripos GmbH Dr. Karsten Henco, EVOTEC BioSystems Dr. Nick Jones, Cambridge Combinatorial Chemistry Dr. John L. Krstenansky, EnzyMed, Inc. Dr. Hugo Kubinyi, BASF AG Dr. Aubrey J. Mendonca, IRORI Dr. Andrea Missio, GlaxoWellcome Medicines Research Centre Dr. Daniel Obrecht, POLYPHOR Ltd. Dr. Dieter Poppinger, Novartis Crop Protection AG Dr. Janice Ramieri, Biotage Division of Dyax Corp. Session: Molecular Diversity and Library Design Novel Combinatorial Chemistry for Drug Lead Discovery Focused Libraries for Lead Expansion and Optimization: A Toolbox Approach Molecular Diversity Preservation and Exploitation for Bioactivity Screenings An Integrated Biocatalytic/Chemical Approach for Bioactive Compounds Strategies and Technologies for Lead Optimization In Vivo Leads from Diverse Libraries: New Diversity Approaches Session: Combinatorial Synthesis Versatile Resin-Bound Synthons and Traceless Linkers Synthesis on a Chip Lead Discovery Using Solid-Phase Chemistry New Resins and Linkers for Combinatorial Synthesis Advances in Parallel Synthesis Chips, Cubes, and Tubes: Taking Library Generation to the Next Level Solid Supported Synthesis of Protein Epitope-Derived Compound Libraries An Open, Multivendor Specification for High-Throughput Organic Chemistry (HTOC): Session: High-Throughput Screening New FCS-Based Read-Out Technologies for Miniaturized, High-Throughput Applications Novel Lead Generation through Integrated Target Discovery and HTS Integrated Discovery with a Novel Automation Concept for HTS Informatics for HSS and HTS at Novartis Crop Protection Session: Computational Methodologies and Chemoinformatics Practical Aspects of the Design and Synthesis of Combinatorial Libraries Drug Discovery through Synergy: The Full Integration of Chemistry and Informatics Integration of Combinatorial Chemistry and Structure-Based Drug Design Similarity and Dissimilarity: A Medicinal Chemist's View Design, Analysis, and Comparison of Combinatorial Libraries *******************************Important************************************** *******The Advanced registration rate for this conference is good until September 4, you must register by that date to save on the fee.************ Please call Cambridge Healthtech at (617)-630-1300 to request a brochure or simply reply to this email and don't forget to give me your email address. Thank You, Amy Dasch Cambridge Healthech Institute Amy Dasch Conference Director Cambridge Healthtech Institute 1037 Chestnut Street Newton, MA 02164 (617)-630-1352 Phone (617)-630-1325 FAX adasch@healthtech.com From owner-repertoires@net.bio.net Wed Aug 12 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Gilson Job Response Newsgroups: bionet.molecules.repertoires Subject: Bioinformatics/Chemoinformatics research positions in Maryland Date: 13 Aug 1998 07:28:24 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 27 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199808121910.PAA20665@indigo14.carb.nist.gov> NNTP-Posting-Host: net.bio.net BIOINFORMATICS/CHEMOINFORMATICS POSITIONS CENTER FOR ADVANCED RESEARCH IN BIOTECHNOLOGY (CARB) Rockville, Maryland One programmer position and one graduate student or postdoctoral position will soon become available in a project to develop a new web-accessible database. The database will contain experimental data -- thermodynamics, structural data, etc. -- on molecular recognition complexes from biology and chemistry. This database is expected to be of value to researchers in both academia and industry. Funding is from NSF and NIST. To work on the project, you should have knowledge of database design and the WWW, as well as the scientific background to understand the data and its applications. To apply, please send email with description of your interests and a CV or resume to gilson_lab@carb.nist.gov CARB (http://www.carb.nist.gov) is a research and training institute about 20 miles from DC. Research here focuses on the structure and function of proteins and other biomolecules. CARB is an EEO/AA Employer. Women and minority candidates are encouraged to apply. From owner-repertoires@net.bio.net Sun Aug 16 23:00:00 1998 Path: biosci!biosci!not-for-mail From: weijunli Newsgroups: bionet.molecules.repertoires Subject: hpce Date: 17 Aug 1998 08:53:48 -0700 Organization: icm Lines: 6 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <35D784F9.320CE2F2@163.com> Reply-To: weijunli@163.net NNTP-Posting-Host: net.bio.net I am a researcher in anti-sense DNA or RNA,I want to use HPCE in oligo-DNA or RNA research.if you have intrests in this area,please e-mail to me :weijunli@yahoo.com From owner-repertoires@net.bio.net Sun Aug 23 23:00:00 1998 Path: biosci!biosci!not-for-mail From: "Z. G. Zhao" Newsgroups: bionet.molecules.repertoires Subject: Combinatorial chemistry positions available at Siddco Date: 24 Aug 1998 01:35:53 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 12 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6rjlqr$qvb@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net SIDDCO, a privately held pharmaceutical company that integrates new enabling technologies into the drug discovery process, currently has numbers of various positions available. For more information please visit the company's webpage at http://www.siddco.com From owner-repertoires@net.bio.net Sun Aug 23 23:00:00 1998 Path: biosci!biosci!not-for-mail From: Sriram Krishnaswamy Newsgroups: bionet.molecules.repertoires Subject: POSTDOCTORAL POSITION(S) Date: 24 Aug 1998 01:32:54 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 46 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <6rjlmj$qsg@mserv1.dl.ac.uk> NNTP-Posting-Host: net.bio.net POSTDOCTORAL POSITION(S) At least one and possibly two postdoctoral positions are available to investigate the enzymology and physical biochemistry of the membrane-dependent proteolytic reactions of blood coagulation. The major areas of interest in the laboratory relate to the specificity and function of the enzyme complex (prothrombinase) that catalyses thrombin formation and the regulation of the initiation of coagulation by the extrinsic Xase complex. These positions provide an opportunity to be trained and make contributions in protein chemistry, molecular biology/protein expression, thermodynamic measurements using steady state fluorescence and isothermal titration calorimetry and kinetic measurements including fluorescence stopped flow and rapid chemical quench. RECENT PUBLICATIONS: Betz, A., Vlasuk, G.P., Bergum, P.W. and Krishnaswamy, S. (1997) Selective Inhibition of the Prothrombinase Complex: Factor Va alters macromolecular recognition of a tick anticoagulant peptide mutant by factor Xa. Biochemistry 36, 181-191 Krishnaswamy, S. and Walker, R.K. (1997) Contribution of the Prothrombin Fragment 2 Domain to the Function of Factor Va in the Prothrombinase Complex. Biochemistry 36, 3319-3330 Krishnaswamy, S. and Betz, A. (1997) Exosites Determine Macromolecular Substrate Recognition by Prothrombinase. Biochemistry, 36, 12080-12086 Baugh, R.J., Broze, G.J. and Krishnaswamy, S. (1998) Regulation of Extrinsic Pathway Factor Xa Formation by Tissue Factor Pathway Inhibitor. J. Biol. Chem., 273, 4378-4386 Betz, A. and Krishnaswamy, S. (1998) Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex. J. Biol. Chem., 273, 10709-10718 Interested candidates should send a CV with names of three referees to: S.Krishnaswamy Joseph Stokes Research Institute Children's Hospital of Philadelphia 310 Abramson 324 South 34th. Street Philadelphia, PA 19104 Voice: (215) 590-3346 Fax: (215) 590-2320 E-mail: skrishna@mail.med.upenn.edu From owner-repertoires@net.bio.net Mon Aug 31 23:00:00 1998 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 1 Sep 1998 08:47:03 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199808280900.CAA20066@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms.