From owner-repertoires@net.bio.net Tue Dec 01 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Guenter Grethe Newsgroups: bionet.molecules.repertoires Subject: Fifth International Conference on Chemical Structures - Call for Date: 2 Dec 1998 01:34:21 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 15 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <742vp2$ib9$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net You will find information about the conference and for submitting abstracts at the following URL. http://ChemWeb.com/conference/5iccs/5iccs.html The site will be updated continously as new information becomes available. Hardcopy announcements will not be mailed out. If you plan to present a paper it is recommended to send in your abstracts as soon as possible as this conference fills up early. Guenter Grethe Conference Chairman From owner-repertoires@net.bio.net Mon Dec 07 22:00:00 1998 Path: biosci!biosci!not-for-mail From: M.Foley@latrobe.edu.au (Dr Michael Foley) Newsgroups: bionet.molecules.repertoires Subject: PEG removal from phage Date: 8 Dec 1998 03:29:05 -0800 Organization: La Trobe University Lines: 20 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <74ig3l$893$1@news.latrobe.edu.au> NNTP-Posting-Host: net.bio.net Hi guys, We are using phage expressing peptides in some bioassays and we think that we are getting non specific killing of our cells by the phage preps. We suspect it is the PEG that we use to precipitate the phage. Does anyone have a good procedure for obtaining lots of phage free from PEG or avoiding PEG altogether? I am aware that you can use CsCl, do people use this routinely. I would also like to hear from people who have immunised mice or rabbits with whole phage expressing peptides. Do you have to CsCl purify them. Does anyone have a convenient protocol for this? Sorry if there are too many questions but all thoughts will be greatly appreciated. Cheers, Mick From owner-repertoires@net.bio.net Thu Dec 10 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Shu-Kun Lin Newsgroups: bionet.molecules.repertoires Subject: Call for bids: software for Molbank journal and/or lab notebook Date: 11 Dec 1998 09:02:15 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 50 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <74rg5q$jei$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear colleagues: Individual scientists or companies are invited to bid for supplying supporting software for MDPI electronic journals, particularly Molbank (ISSN 1422-8599, Vol. 1, 1999). Structure and spectrum display software developers are invited. The accepted supplier must have a demonstrated, working software based on Internet website browser. It will enable authors, manuscript referees and readers to upload (if permitted), download and view structural and spectroscopic as well as any other graphic numerical data and manipulate it on the internet comfortably. Visit http://www.ch.ic.ac.uk/ectoc/echet98/ for a perhaps the best example! For sample papers of Molbank, please visit the http://www.mdpi.org/molbank/indextemp.htm website. Molbank is the first chemistry journal preserving experimental data of individual compounds. It is evolved from the MolBank section of the journal Molecules. Structure and spectrum display software for Molbank journal must be a very promising product for electronic lab notebook. Therefore, Molbank will be regarded as an exhibition place for promoting your products. We will therefore not pay for any charge and will not collect any advertisement fee. The accepted provider will have the exclusive right of using its software within a period of 1 year. However, in order to promote fare competition and encourage innovation on software development, Molbank keeps its right to freely choose another software provider and switch to another software. Molbank will also publish the related software reviews, also free of charge. Please submit your proposal by e-mail to Dr. Shu-Kun Lin, Managing Editor, Molbank before the end of 1998. --------------------------------------------------------- Dr. Shu-Kun Lin Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland http://www.mdpi.org/ E-mail lin@mdpi.org Tel. +41 79 322 3379, Fax +41 61 302 8918 -------------------------------------------------------- From owner-repertoires@net.bio.net Thu Dec 10 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Michael Sherrell Newsgroups: bionet.molecules.repertoires Subject: ACT 396 for sale Date: 11 Dec 1998 08:16:26 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 21 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <01BE247A.049C1320@oak-pm2-1-193.dialup.slip.net> NNTP-Posting-Host: net.bio.net For sale: 1998 Advanced Chemtech Model 396 Multiple Biomolecular Synthesizer, unused, ~2/3 of new price. Also available: Perkin Elmer Sciex API III+ LC/MS/MS, electrospray, APCI, $79,000 Hewlett Packard 5989B LC/MS, electrospray, extend mass range, 1995 model, $45,000 Plus many ABI and other sequencers and synthesizers (and service arrangements for synthesizers), flow cytometers, NMRs and SEMs listed on my website. Michael Sherrell Grizzly Analytical 707 887 2919/fax 707 887 9834 www.grizzlyanalytical.com From owner-repertoires@net.bio.net Sun Dec 13 22:00:00 1998 Path: biosci!biosci!not-for-mail From: 915603@candseek.com Newsgroups: bionet.molecules.repertoires Subject: JOBOP Senior Medical Writer Date: 14 Dec 1998 02:01:31 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 23 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199812112129.NAA28981@net.bio.net> NNTP-Posting-Host: net.bio.net I am seeking an individual within the following conditions: A Senior Medical Writer to prepare clinical documents for submission to domestic and international regulatory agencies. Minimum 5 years experience in the pharmaceutical industry preparing clinical reports in multiple therapeutic areas including oncology and antivirals. We offer an Outstanding opportunity, Competitive Salary and Excellent Benefits Geographic Location of Position: Southern California If you know anyone that might be interested, please forward this to them or contact: Louis Carlson Diedre Moire Corp., Inc. Voice: 609-584-1601 ext. 216 Fax: 609-584-9575 Email: 915603@candseek.com From owner-repertoires@net.bio.net Sun Dec 13 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Frank Buehling Newsgroups: bionet.molecules.repertoires Subject: Position opening Date: 14 Dec 1998 02:44:46 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <752o9d$p2j$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net At the Institute of Immunology, Otto von Guericke University Magdeburg Germany a position for a PhD student is available immediately for a period of three years. The research project is supported by Deutsche Krebshilfe and focus on cysteine proteinases and their role in invasion and metastasis of lung tumors. Candidates should be graduated in biology biochemistry, chemistry or pharmacology. Experience in cell culture techniques and molecular biology is desirable. Please address inquiries to: Frank Buehling, Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg; Germany Phone: +49 391 67 13311, Fax: +49 391 67 13291 e-mail: frank.buehling@medizin.uni-magdeburg.de. ************************************************** Frank Buehling Institute of Immunology Otto-v.-Guericke-University Magdeburg Leipziger-Str. 44 D-39120 MAGDEBURG Germany Ph: +49 391 67-13311 (-13283) Fx: +49 391 67-13291 (-13312) * http://www.med.uni-magdeburg.de/fme/zim/ieim/SFB387/ ************************************************** From owner-repertoires@net.bio.net Sun Dec 13 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Shu-Kun Lin Newsgroups: bionet.molecules.repertoires Subject: The disagreement with Springer on Molecules is settled Date: 14 Dec 1998 02:10:18 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 32 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <752n3s$odq$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Hi, The disagreement with Springer on the journal Molecules (http://www.mdpi.org/molecules/) is settled. Dr. Shu-Kun Lin (MDPI) and Dr. Rainer Stumpe (Springer) met in Basel today, 11 December 1998, and agreed (both signed on a "Memorandum of Understanding") that the two journal "Molecules" and "Molecules Online" have different scope and can co-exist. Neither party will, in future, interfere in any way with the other's rights to publish their respective journal. Afterwards, Dr. Lin has no further claims against Springer-Verlag. MDPI's Molecules immediately resumed publication this afternoon. Thanks! Happy new year of 1999 to all of you! Shu-Kun --------------------------------------------------------- Dr. Shu-Kun Lin Editor-in-Chief, Molecules (ISSN 1420-3049) Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland http://www.mdpi.org/ E-mail lin@mdpi.org Tel. +41 79 322 3379, Fax +41 61 302 8918 -------------------------------------------------------- From owner-repertoires@net.bio.net Mon Dec 14 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Michael Sherrell Newsgroups: bionet.molecules.repertoires Subject: ABI Procise 492 for sale Date: 15 Dec 1998 06:55:28 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 22 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <01BE2778.A92CD900@oak-pm1-58-186.dialup.slip.net> NNTP-Posting-Host: net.bio.net ABI 492 Procise protein sequencer, was $132,000 new, not used in 2 = years, $59,000 For sale: 1998 Advanced Chemtech Model 396 Multiple Biomolecular = Synthesizer, unused, ~2/3 of new price. Please call or email if you'd like more details. Also available: many ABI and other sequencers and synthesizers (and = service arrangements for synthesizers), HPLC/MSs, flow cytometers, NMRs = and SEMs listed on my website. Michael Sherrell Grizzly Analytical 707 887 2919/fax 707 887 9834 www.grizzlyanalytical.com From owner-repertoires@net.bio.net Tue Dec 15 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Kim Takita Newsgroups: bionet.molecules.repertoires Subject: Combinatorial Chemistry for Materials Date: 16 Dec 1998 04:56:52 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 42 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <756b8u$s75$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Final Announcement & Call for Posters http://www.knowledgefoundation.com/events.html How to Effectively Utilize Combinatorial Approaches for New Materials Discovery January 21-22, 1999 * San Jose, California Polymers * Catalysis * Electronic Materials * Successful Case Studies * Hurdles to Overcome * Analytical Considerations * Automation * Ultra-Fast Assays * Latest Data and Insights from Industrial, Government and Academic Researchers * Interactive Discussion Sessions * Targets for Opportunity * Benchmarking and Comparative Technology Review * Chemometric techniques and mathematical models * "Combination" approaches vs. "Pure" Combi-Chem * Informal Networking Opportunities with Potential Research Partners and Collaborators For more information, please visit our web-site http://www.knowledgefoundation.com/events.html or contact me at kmtakita@knowledgefoundation.com with your mailing address and I will forward to you the conference brochure. ------------------------------------------------------------------------ ---------- Kim Takita Vice President The Knowledge Foundation, Inc. 101 Merrimac Street Boston, MA 02114 Phone: 617-367-7979 ext. 202 Fax: 617-367-7912 E-Mail: kmtakita@knowledgefoundation.com http://www.knowledgefoundation.com From owner-repertoires@net.bio.net Wed Dec 16 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Laboratory Robotics Interest Group Newsgroups: bionet.molecules.repertoires Subject: Call for Papers Date: 17 Dec 1998 02:23:01 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 26 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <75albl$fat$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net We are planning to include a section of presentations dedicated to the "use of automation in combinatorial chemistry" at the next Laboratory Robotics Interest Group meeting (February 1999). The meeting will be held in Somerville, New Jersey. Currently, I am looking for people interested in making a presentation at that meeting. Any topics involving the use of automation for Combinatorial Chemistry will be considered. If you or any of your colleagues would be interested in presenting, please contact me with your topic. Just a brief description is all we need at this time, abstracts should be submitted closer to the meeting date. Regards, Andy Zaayenga Secretary, The Laboratory Robotics Interest Group LRIG Home & Mid Atlantic Chapter voice: (732)302-1038 fax: (732)302-9080 mailto:andy.zaayenga@lab-robotics.org web site: http://lab-robotics.org From owner-repertoires@net.bio.net Wed Dec 16 22:00:00 1998 Path: biosci!biosci!not-for-mail From: Kit Lam Newsgroups: bionet.molecules.repertoires Subject: Conference Date: 17 Dec 1998 02:19:26 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 158 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <75al6i$fa3$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Colleagues, I would like to invite you to attend the Second International Conference on Combinatorial Library Methods for Basic Research and Drug Discovery to be held at Tucson, Arizona on January 10-12, 1999. The conference covers many areas of combinatorial chemistry and combinatorial biology. Topics include small molecule libraries, peptide libraries, nucleic acid libraries, bisynthetic libraries, high-throughput screening, robotics, and application of computational chemistry in combinatorial chemistry. Over twenty experts in these areas have been invited to speak at the conference. In addition there are many poster presentations. Below is the program for the conference. Please visit the Arizona Cancer Center web site for details and registration or contact me for questions. Best regards, Kit S. Lam Associate Professor of Medicine Arizona Cancer Center University of Arizona International Conference on Combinatorial Library Methods for Basic Research and Drug Discovery January 10-12, 1999 Conference Schedule Location: Arizona Health Sciences Center DuVal Auditorium Tucson, AZ 85724 DAY ONE, Sunday, Jan 10 7:00 a.m. Registration (Continental Breakfast) 8:45-9:00 a.m. Welcome and Announcements (Sydney Salmon, and Kit S. Lam) Scientific Session I: Biological and Synthetic Peptide Combinatorial Libraries Chairman: Brian Kay 9:00-9:30 a.m. George Smith, University of Missouri (Discovering Effective Peptide Vaccine Components via Epitope Discovery) 9:30-10:00a.m. Jill Winter, Chiron Corporation (New Applications of Diversity Libraries) 10:00-10:30a.m. Brian Kay, University of Wisconsin (Convergent Evolution with Combinatorial Peptides) 10:30-10:45a.m. Coffee Break 10:45-11:15 a.m. Kit Lam, Arizona Cancer Center (The One-bead one-compound Combinatorial Library Approach) 11:15-11:45a.m. Songyang Zhou, BaylorCollege of Medicine (Analysis of Protein-Protein Interactions via Peptide Libraries) 11:45-12:05p.m. Eric Adam, New England Biolabs, Inc (A minimal alpha-helical library for in vivo selection of active peptides) 12:05-1:30p.m. Lunch Scientific Session II: High-throughput synthesis and assay, and others Chairman: Michal Lebl 1:30-2:00p.m. Mario Geysen, Glaxo Wellcome (Combinatorial Chemistry - Past, Present, and Future) 2:00-2:30p.m. Michal Lebl, Trega Biosciences Inc (Solid Phase Synthesis Based on Centrifugation of Tilted Plates) 2:30-3:00p.m. Sheila DeWitt, Orchid Biocomputor, Inc (Synthesis in a Chip) 3:00-3:15p.m. Coffee Break 3:00-3:30p.m. Peter Strop, Selectide Corporation 3:30-3:50p.m. Wolfgang Rapp, Rapp Polymere (A Molecular Approach for Automatic Paralled Synthesis of Small Organic Molecules) 3:50-4:10p.m. Wolin Huang, COR Therapeutics, Inc (Traceless Solid-phase Synthesis of a Benzimidazole Library) 4:10-6:00p.m. Poster Presentation DAY TWO Monday, January 11 7:15-8:15a.m. Poster Viewing (Continental Breakfast) Scientific Session III: Small Molecule Combinatorial Libraries Chairman: Kevin Burgess 8:15-8:45a.m. Jon Ellman, UC Berkeley 8:45-9:15a.m. Peter Wipf, Univ of Pittsburg (Development of a Fluorous Strategy for Organic Synthesis) 9:15-9:45a.m. Kevin Burgess, Texas A&M Univ (Solid phase synthesis and conformational analysis of rigid cyclic beta-turn peptidomimetics ) 9:45-10:00a.m. Coffee Break 10:00-10:30a.m. Jack Baldwin, Pharmacopeia, Inc (Combinatorial Libraries - Screening and Analysis of Results) 10:30-11:00a.m. Richard Houghten, Torry Pine Research Institute (Use of Mixture-Base Positional Scanning CombinatorialLibraries for the Discovery of Highly Active Small Molecules and Peptide Vaccine Immunogens) 11:00-11:30a.m. John Krstenansky, EnzyMed, Inc (The Integration of Chemical and Biocatalytic Approaches for Combinatorial Syntheses) 11:30-1:00p.m. Lunch Scientific Session IV: Computational Chemistry, and Molecular Design Chairman: Victor Hruby 1:00-1:30p.m. Robert Pearlman, The University of Texas (Novel Alogrithms for the Design of Diverse and Focussed Combinatorial Libraries) 1:30-2:00p.m. Irwin Kuntz, UCSF School of Pharmacy (Combinatorial Libraries and Structure-base Design) 2:00-2:30p.m. Victor Hruby, Univ of Arizona (Design and Synthesis of Linkers and Ligands for Solid Phase Synthesis of Peptide and Nonpeptide Peptidomimetics) 2:30-2:50p.m. Edith Chan, Selectide Corporation (Design of Generic Combinatorial Library for Lead Discovery) 2:50-3:10p.m. Richard Cramer, Tripos, Inc (Validation of Chem Space Topomer Shape Similarity Searching in Virtual Libraries) 3:45-8:00p.m. Conference Event DAY THREE Tuesday, January 12 7:30-8:00a.m. Continental Breakfast Scientific Session V: Nucleic Acid and Protein Combinatorial Libraries Chairman: Jack Keene 8:00-8:30a.m. Lawrence Loeb, Univ of Washington (Creation of new enzymes for biochemistry and cancer gene therapy) 8:30-9:00a.m. Erkki Ruoslhti, The Burnham Institute 9:00-9:30a.m. Richard Roberts, California Institute of Technology (Optimized Synthesis of RNA-Protein Fusions for In Vitro Protein Selection) 9:30-9:45a.m Coffee Break 9:45-10:15a.m. Jack Keene, Duke University Medical Center (Elucidation of messenger RNA Epitopes by Iterative Selective Selection of Naturally occurring Cellular RNA Sequences) 10:15-10:45a.m. Ed Brody, NeXstar Pharmaceuticals, Inc (SELEX derived aptamers: Agents for Therapeutics, Diagnostics and Target Validation) 10:45-11:05a.m. Mark Bray, Ontario Cancer Institute (SKULL libraries: Combinatorial protein Libraries with a Built-in Search Engine) 11:05-11:15a.m. Concluding Remarks (Kit S. Lam) 11:15a.m. Adjourment 1:30-3:30p.m. Hands-on workshop, organized by Michal Lebl and Brian Kay (Located at the Keiwit Auditorium, Arizona Cancer Center) From owner-repertoires@net.bio.net Wed Dec 16 22:00:00 1998 Path: biosci!biosci!not-for-mail From: "Marko Dolinar, JSI" Newsgroups: bionet.molecules.repertoires Subject: 6th Brdo Symposium Announcement Date: 17 Dec 1998 02:24:56 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 79 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <75alf2$fcg$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear colleagues: We would like to announce that the VIth International Symposium on PROTEINASE INHIBITORS AND BIOLOGICAL CONTROL will be held at Brdo by Ljubljana, Slovenia from June 9 to 13, 1999 Organised by: Vito Turk, Ljubljana, Slovenia Hans Fritz, Munich, Germany Bonnie Sloane, Detroit, USA The success of the Research Symposia on Proteinase Inhibitors and Biological Control, first organised in 1987 at Brdo, Slovenia, confirmed the need to continue such meetings. The continuing progress and the high level of interest in this field, coupled with the desirability of a European "Gordon Conference style" of meeting, has led us to organise the sixth Symposium in 1999. Besides the presentation of the latest results, the social structure of the meeting will continue to be such as to encourage establishment of new personal contacts, exchange of scientific ideas and results, and opportunities to meet young scientists In this Symposium therefore we will be emphasising specific topics of major current progress and excitement (in the research of aspartic, cysteine, metallo and serine proteases and their inhibitors) as well as giving opportunity for the presentation of new areas of particular interest: 1. The biological role of proteolysis in: - antigen presentation - apoptosis - plant defence system - insects and parasites - tumour growth and invasion - Alzheimer's disease - viral related diseases 2. Biochemical principles of proteolysis: - Characterisation and structure of proteinases and their inhibitors - Insights into function and mechanism revealed by genetic engineering approaches 3. New ideas and prospects. There will be about 35 oral presentations given by invited lecturers, and a poster session. For further information please contact Prof. Dr. Vito Turk at the address below: Prof. Dr. Vito Turk director Jozef Stefan Institute Jamova 39 SI-1000 Ljubljana, Slovenia Phone: ++ 386 61 17 73 212 Fax: ++ 386 61 27 35 94 E-mail: Vito.Turk@ijs.si ____________________________ An Internet site with relevant information was set up and is available at the following address: http://bio.ijs.si/conf/brdo99.htm More information, including the abstract submission form, instructions for poster preparation, registration fee and the names of invited speakers will be prepared by March 1999. ____________________________