From owner-repertoires@net.bio.net Tue Feb 02 22:00:00 1999 Path: biosci!biosci!not-for-mail From: The Antibody Resource Page Newsgroups: bionet.molecules.repertoires Subject: Are you looking for an Antibody? Visit the Antibody Resource Page! Date: 3 Feb 1999 07:14:09 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 22 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <36B8419C.6EB@antibodyresource.com> NNTP-Posting-Host: net.bio.net The Antibody Resource Page (http://www.antibodyresource.com/) now maintains a list of custom antibody suppliers. If you are interested in the production of custom monoclonal or polyclonal antibodies see this invaluable guide at: http://www.antibodyresource.com/customantibody.html Also, take a look our "How to Find an Antibody" section (http://www.antibodyresource.com/customantibody.html) which outlines a variety of ways online and offline to locate your antibody of interest. This section has links to online antibody search engines and reference manuals such as the MSRS Catalog of Primary Antibodies and Linscott's Directory. Don't forget to visit our other sections on educational resources and stop by to see our antibody gallery. ps. The ARP was voted among the top 25 biotechnology webpages for 1997 by Genetic Engineering News! From owner-repertoires@net.bio.net Tue Feb 02 22:00:00 1999 Path: biosci!biosci!not-for-mail From: vermeim Newsgroups: bionet.molecules.repertoires Subject: Int Sympo Molecular Genetics of Mental Disorders Date: 3 Feb 1999 07:13:40 -0800 Organization: ImagiNET Lines: 12 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <799eso$3lb$1@news.imaginet.fr> NNTP-Posting-Host: net.bio.net International Symposium "Molecular Genetics of Mental Disorders" Date : December 1-3, 1999 Castres (Tarn) France The final scientific program is now available on http://www.entretiens-du-carla.com From owner-repertoires@net.bio.net Tue Feb 02 22:00:00 1999 Path: biosci!biosci!not-for-mail From: vermeim Newsgroups: bionet.molecules.repertoires Subject: Int Sympo Molecular Genetics of Mental Disorders Date: 3 Feb 1999 07:15:36 -0800 Organization: ImagiNET Lines: 12 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <799ffe$3s8$1@news.imaginet.fr> NNTP-Posting-Host: net.bio.net International Symposium "Molecular Genetics of Mental Disorders" Date : December 1-3, 1999 Castres (Tarn) France The final scientific program is now available on http://www.entretiens-du-carla.com From owner-repertoires@net.bio.net Tue Feb 09 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Steve Heller Newsgroups: bionet.molecules.repertoires Subject: Chemistry & the Internet Meeting Date: 10 Feb 1999 02:55:48 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 60 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <79m9tf$1pu$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net The ChemInt'99 draft program is now available at the conference web site: www.chemint.org. The list of all invited speakers and virtually all panel members is now complete and listed in the program. ChemInt'99 will be held in at Georgetown University in Washington DC on September 25-27, 1999. Poster talks/papers submissions will be accepted only via the web site starting in the spring. The main lecturers for the meeting will be: Alan Arnold, University College (UNSW) Steven Bachrach, Northern Illinois University Robert Bovenschulte, ACS Stephen Boyer, IBM Karl Harrison, Oxford University Clemens Jochum, Deutsche Bank Gary Mallard, NIST Tom Pierce, Rohm & Haas Jerome Reichman, Vanderbilt Achim Zielesny, Bayer AG Steven S. Zumdahl, University of Illinois at Urbana-Champaign The corporate sponsors for the meeting are: ChemWeb and the Internet Journal of Chemistry Technical Sponsors are: ACS CINF Division ACS COMP Division The Chemical Structure Association (CSA) Georgetown University - Department of Chemistry International Union of Pure and Applied Chemistry (IUPAC) (pending) Japan Association for International Chemical Information (JAICI) Special Libraries Association (SLA) Chemistry Division Royal Society of Chemistry (RSC) A list of current exhibitors is on the web site. This note is also to remind people that webcasting (video/audio) and/or slides for more tha a dozen of the Chemistry and the Internet (ChemInt'98) meeting talks, held in Irvine CA in September, are also available on the ChemInt web site (www.chemint.org). A 42 page report on the meeting by Wendy Warr is also available. Steve Heller Steve Heller, Guest Researcher NIST/SRD, Mail Stop: 820/113 820 Diamond Avenue, Room 101 Gaithersburg, MD 20899-2310 USA E-mail: chem@feldmann.nist.gov From owner-repertoires@net.bio.net Tue Feb 09 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Jim Ostrem Newsgroups: bionet.molecules.repertoires Subject: Nanosyn position announcement Date: 10 Feb 1999 02:38:30 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 31 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <01BE5364.CA246390@a26.pm3-22.theriver.com> NNTP-Posting-Host: net.bio.net N A N O S Y N - Nanoscale Combinatorial Synthesis Inc. We have immediate openings for the following two positions: * Ph.D. Chemist: Applicants should have two to five years experience in solid phase organic chemistry and combinatorial synthesis of small molecule libraries. Experience with solution phase chemistry and analytical methods for solid/solution phase chemistry is also desirable. * B.S./M.S. Chemist: Applicants should have one to two years experience in solid phase/solution phase synthetic chemistry. Experience with combinatorial synthesis is a plus. Please direct inquiries to: Dr. Anatoly Mazurov Nanoscale Combinatorial Synthesis Inc. 9062 S. Rita Rd. Tucson, AZ 85747 Email: amazurov@nanosyn.com Website: www.nanosyn.com N A N O S Y N - exploring miniaturized synthesis and distribution technologies. We provide diverse and targeted libraries with proprietary building blocks, and access to more than 60,000 analytically characterized compounds for drug discovery research. From owner-repertoires@net.bio.net Sun Feb 14 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. Wendy A. Warr" Newsgroups: bionet.molecules.repertoires Subject: Information in Pharmaceutical Industry Date: 15 Feb 1999 01:53:12 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 34 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7a8q8a$9ce$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net A colleague who is not on this list has asked me the following: "We are looking for sources of information/articles which stress the fact that the volume of information available (and which we must process) in the pharmaceutical area is considerably greater compared to other industrial sectors in the "chemical" industry e.g. Agrochemicals, Dyestuffs, Plastics, Photographic, Organic Chemicals, Inorganic Chemicals, Paints etc.... The relative number of scientific and technical journals or articles(and their relative size) or patents in the different areas would, for example be a quantitative argument but there are probably also qualitative arguments too." My colleague can do a patent count himself, I guess, and he has some figures to show there are 5 times as many journals aimed at the pharmaceutical industry as at the other industries. We can probably find the number of journals in total and there was some stuff on the chminf-l list (when?) about the growth in the literature in general. Does anybody have any other ideas for us, please? All suggestions gratefully received. Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-repertoires@net.bio.net Wed Feb 17 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Bob Snyder Newsgroups: bionet.molecules.repertoires Subject: Call For Papers - Combinatorial Chemistry Informatics at ACS New Date: 18 Feb 1999 03:39:15 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 67 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7agn3p$8gk$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net The Chemical Information (CINF) Division is planning a series of sessions on Combinatorial Chemistry Informatics at the fall ACS meeting in New Orleans (August 1999). Each session will focus on a different aspect in the combinatorial chemistry process: from library design, virtual library analysis, and automated synthesis, through high-throughput screening. The four sessions will be presented sequentially to preserve the natural workflow. If you would like submit a talk for one of these sessions please contact the session organizer at the end of each session description below. Combinatorial Chemistry Informatics: Library Design Library design can be the most critical aspect in determining the success or failure of the resulting combinatorial library. Selection of the scaffold and R-groups (reagents) can have a profound effect on how well the library members bind to the desired target receptor. Information-based approaches to the design of combinatorial libraries is resulting in smaller, more effective libraries. This session will present novel techniques for library design and registration. Please contact Bob Snyder (bobs@mdli.com) for further information and submission of abstracts. Combinatorial Chemistry Informatics: Virtual Library Analysis/Diversity Assessment This session will focus on the creation and analysis of virtual combinatorial libraries as a means for pre-screening libraries prior to their synthesis. Various diversity measurements will be presented and their effectiveness measured. Please contact Bob Snyder (bobs@mdli.com) for further information and submission of abstracts. Combinatorial Chemistry Informatics: Automated Synthesis and Validation This session will cover information management and tracking methods for all steps of medium or high throughput synthesis. This includes experimental set-up, synthesis techniques, purification methods for synthesized compounds, analytical methods for compound verification, and registration of validated compounds. Speakers from industry, academia, or government who can describe approaches to information management for these issues as applied to their own research programs are preferred. Please contact Terry Wright (terryw@mdli.com) for further information and submission of abstracts. Combinatorial Chemistry Informatics: High-Throughput Screening Combinatorial libraries pose unique challenges to software programmers and developers who provide informatics programs for the drug discovery industry. These challenges include controlling robotic workstations used to create the libraries as well are register and validate the libraries before they are run in High-Throughput Screening (HTS) programs. This sessions will focus on how the presenters companies are dealing with this issue. Please contact Ron Delmendo (rond@mdli.com) for further information and submission of abstracts. Please submit your talks as soon as possible since each session will be limited to one half day. Bob Snyder Director, Chemistry Marketing MDL Information Systems email: bobs@mdli.com telephone: 510-895-1313 Never stop searching. From owner-repertoires@net.bio.net Thu Feb 18 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Michael Sherrell Newsgroups: bionet.molecules.repertoires Subject: ABI 377 for sale Date: 19 Feb 1999 01:56:20 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 48 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <01BE5B56.AA1A06A0@oak-hiper1a-41-105.dialup.slip.net> NNTP-Posting-Host: net.bio.net Newly for sale: ABI 377 DNA sequencer, XL, 96 lanes, under transferrable Perkin Elmer service contract until March 2000. Price: $105,000. I also have these peptide and oligo synthesizers and sequencers, LC-mass specs and NMRs for sale: Synthesizers and sequencers: ABI 394 synthesizer, valve blocks rebuilt, warranteed: $12,500 ABI Procise 492 protein sequencer, $59,000 ABI 3948 synthesizer: inquire ABI 390Z synthesizer, 50-100uM yields: $4,000 ABI 373 stretch, 5-filter, Genescan, under ABI service: $19,500 Li-Cor 4000LS, 1994 model: <$20,000 ABI 430, working: $6,000 ABI 430, rebuilt, warranteed: $10,500 ABI 433, upgraded by ABI from 431: $39,000 Advanced ChemTech 396 Multiple Biomolecule Synthesizer, unused: $45,000 PerSeptive 9050+, $6,000 + a variety of other ABI, PerSeptive, HP, Biosearch, ACT, etc. synthesizers and sequencers LC-MS: PE Sciex API III+, 5yrs old, ES, APCI (installation available): $82,000 Finnigan TSQ 7000, installed, warranty: $149,000 Finnigan TSQ 700, 1995; NOT Y2K compliant; under Finnigan service now: $80,000 HP 5989B, extended mass range (2000 amu), hex ion guide (HPLC, installation & warranty available): $45,000 NMRs: Bruker AMX-500, installed: $175,000 Bruker AC-250, running in lab now: $30,000 Varian Gemini 300: $70,000 . Please contact me to discuss any of these, or if you have any items you might like to sell. Michael Sherrell Grizzly Analytical 707 887 2919/fax 707 887 9834 www.grizzlyanalytical.com From owner-repertoires@net.bio.net Tue Feb 23 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. Shu-Kun Lin" Newsgroups: bionet.molecules.repertoires Subject: Emperor's new clothes Date: 24 Feb 1999 08:18:30 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 33 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7b16lr$h6j$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Hi, Is there any perfect example in science that fits into the famous story of "emperor's new clothes"? For many years, I find only the famous "dissipative structure theory" is a perfect example of "emperor's new clothes". This is also one of the reasons I launched a new scientific journal Entropy (ISSN 1099-4300) at the website. I put my opinion in the Editorial at the website. I tried to challenge Dr. Prigogine's theory directly but failed to meet him in a conference. He very often agreed to gave talk at a conference but sent his associates there instead. I hope nobody calls me a stupid boy or the stupid boy. What do you think? Sorry to post this message on Sunday (Thank you for your tolerance.), because I can treat "entropy" only as my humble hobby which I can do only at the weekend and while my son and my wife still sleep. I hope someday those powerful guys who can recommend Prigogine for Nobel prize offer me a position for me to concentrate on my beloved research: I can figure out a really useful theory. Shu-Kun ---------------------------------------------------------------- Dr. Shu-Kun Lin MDPI, Saengergasse 25, CH-4054 Basel, Switzerland Tel. +41 79 322 3379, Fax +41 61 302 8918 E-mail: lin@mdpi.org URL: http://mdpi.org/lin/ From owner-repertoires@net.bio.net Tue Feb 23 22:00:00 1999 Path: biosci!biosci!not-for-mail From: andy.zaayenga@bigfoot.com (Andy Zaayenga) Newsgroups: bionet.molecules.repertoires Subject: Announce: Laboratory Robotics Interest Group meeting Date: 24 Feb 1999 06:51:46 -0800 Organization: Netcom Lines: 342 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <36cda16e.12027505@nntp.ix.netcom.com> NNTP-Posting-Host: net.bio.net Don't miss our meeting this Monday! LRIG News: The New England, SouthEast and San Diego Chapters are conducting registration drives to enroll new members. Their web sites may be linked to from the LRIG Home page. The Discussion Mailing List http://lab-robotics.org/discussion_maillist.htm has over 500 subscribers as of 2/17/99. The LRIG Home web site received a new look - check us out! http://lab-robotics.org Over 20,000 visitors since September 1997! The LRIG Discussion Web Debuts on 2/19/99 See the Discussion Web home page http://www.lab-robotics.org/Web_Discuss/ for more details. Meeting Presentations are now on line! http://lab-robotics.org/meeting_ s.htm Presentations from the meetings will be archived on this site whenever possible. ______________________________________ The Laboratory Robotics Interest Group February 1999 Meeting Agricultural & Analytical Applications Date: Monday, February 22, 1999 Place: Raritan Valley Community College Advanced Technology Communication Center Route 28 & Lamington Road, North Branch, NJ  08876 Itinerary: Social Period with Food & Refreshments and Poster Session, Lobby -  4:30 to 6:30 PM Presentations and Discussion, Auditorium - 6:30 to 8:30 PM Pre-Registration: Requested, not required.  Registering will allow us to more accurately gauge seating requirements and refreshment needs.  Indicate names of attendees and company affiliation. Email: andy.zaayenga@lab-robotics.org Phone: (732)302-1038 Fax: (732)302-9080 Agenda:  This is a combined session meeting focusing on Agricultural Applications and Analytical Applications.  The Social Period will feature food and refreshments.  Members interested in presenting a poster are encouraged to do so.  Open career positions at your company may be announced or posted.  There is no fee to attend the meeting.  Bring a business card to drop in the registration fishbowl - it eases registration and qualifies you for the rosewood pen set drawing. Sharon Reed is chairing the Agricultural Session.  Bill Haller is the chair for Analytical Applications.  Their contact information is listed below. ___________________________________________________________ Agricultural Session ___________________________________________________________ Presentation:  Custom Modifications to Packard MultiPROBE 208 Liquid Handler and Asymtek Century 702 Fluid Dispenser in Dispensing Agar-Based Insect Diet Media for Insecticide Discovery in Agricultural Biotechnology. Tracy Michaels, John Cesarek, Stacey Replogle,Mark Hurst,Lisa Fertsch and Scott Breidenthal Mycogen Corporation, Packard, Asymtek MichaelsT@mycogen.com A major technical goal of our program is to reliably and consistently dispense volumes types of insect container formats, including the standard 96-well footprint, used in insecticide screening. Dispensing of insect diet posed special challenges to the liquid dispensing process due to the elevated temperature and mixing requirements of the liquid media. Use of available laboratory liquid handing equipment with the insect diet resulted in solidification and clogging of lines and/or dispense heads. Various modifications were implemented including specialized heating, insulation, dispense timing, dispensing heads, tips, programming, and washing. These developments resulted in consistent dispensing of the liquid insect diet with the Packard MultiPROBE 208 and Asymtek Century 702 . Additions to the Packard MultiPROBE 208 included an extension on the Z-axis range to enable the probes to access the liquid insect-diet reservoir positioned below the deck. The Asymtek Century 702 was integrated with a Watson-Marlow Multi-Channel Peristaltic Pump for coordinated accuracy of dispensing into containers with a variety of dimensions and volumes. Each dispensing system has its own advantages and unique roles in meeting the needs of the insect bioassay system and will be discussed in detail. ___________________________________________________________ Presentation:  Migration From a Traditional AgChem Screen to a Miniaturized HTS Program Robert Bisbing, Rohm and Haas Company, Spring House, PA Within the last two years, the strategy for and migration to a "high throughput" first level screening effort has restructured the sample handling, data acquisition, and biological testing areas within our overall evaluation program for identifying agriculturally active compounds. This change was initiated to facilitate, broaden and reduce costs associated with the sample acquisition process and to improve the quality of compounds entering our more advanced greenhouse screens. As an interim stage, traditional screens requiring large amounts of test compound were replaced with similar but modified tests requiring less compound turized screens were developed and validated within each area of interest (fungicides, insecticides and herbicides). Means for converting our powder archive to liquid format was initiated along with sample handling strategy that would be consistent with new screens being developed for implementation at the workstation level. A brief description with overheads/slides of 4-5 of these tests will be given. ___________________________________________________________ Presentation:  The AMPLE(TM) Multiplex Synthesis Device Robert E. Hormann, Daryl Gilbert, Wilhelm Glaeser Rohm and Haas Company, Spring House, PA In the Rohm and Haas agrochemicals group, we have developed a medium-scale (75 mL x 15 vessels), semi-manual, parallel synthesis device called AMPLE(TM) (Amplified Multiplex Preparation of Library Ensembles). Once a lead structure is identified, possibly by combinatorial methods, a subset or ensemble of structures related to the active members of that library may be scaled-up, or amplified. The basic AMPLE(TM) design is flexible, compact, scalable, and adaptable to the numerous conditions of nonuniformity which are typical of traditional organic synthesis. ___________________________________________________________ Poster:  FLUORESCENCE DETECTION TO MONITOR FUNGAL GROWTH IN MICROPLATE-BASED FUNGITOXICITY ASSAYS M. Elizabeth Miller and Christine S. Jany Rohm and Haas Company, Spring House, PA The fluorescent stain, FUN-1, available from Molecular Probes, was evaluated for its utility as a live/dead marker with fungi used in our current in-vitro cytotoxicity assays. ___________________________________________________________ Analytical Session ___________________________________________________________ Presentation:  LABORATORY AUTOMATION IN PHARMACEUTICAL DEVELOPMENT: PERSPECTIVES FOR THE NEW MILLENNIUM Stephen Scypinski, Analytical Development The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ Incredibly, the use of laboratory automation and robotics in pharmaceutical analysis and drug developme any reported examples of success stories, trials and tribulations of pharmaceutical dosage form automation. More recently, the automation wave has hit the drug discovery area quite hard and it is amazing to see the rapid implementation of automation and robotics in areas such as high throughput screening and combinatorial chemistry. If one compares the "ramps of utilization" between discovery and development, one will find (without surprise) that discovery has far outstripped development in it’s utilization of automation. The question to be asked is…WHY? I have asked myself the aforementioned question and have tried to answer it by factoring in the rigidities we in development are confronted with such as regulatory methods, cGMP compliance, method, system and computer validation, documentation and training. Indeed, if any or all of these factors are contributing to the non-usage of robotics in drug development and pharmaceutical analysis, their contribution is almost certainly small. One must begin to ask the question: "If we in development are indeed going to integrate robotics into our repertoire of analytical tools and techniques, what needs to be done to make this happen?" Having joined a new organization less than a year ago helps one establish a perspective and gives a new beginning and new ideas. One approach being tried is to firmly "build automation in" when designing methods and sample preparation schemes. This accomplishes several things. 1) It shifts the paradigm of conventional sample preparation to that compatible with automation (i.e. homogenization) 2) Translating/transferring manual methods to an automated system becomes more facile and 3) Persons utilizing both see more equivalency between them and hence, usage is more readily accepted. A tangential approach to the implementation of "classic automation" is the development of new analytical instrumentation based on high throughput technology, which holds great promise as one of the premier analytical techniques of tomorrow. Using several exa automation applied to the challenges we all face as we move into the 21st century will be highlighted. ___________________________________________________________ For more information contact: Executive Chair: Dennis France dennis.france@pharma.novartis.com (908) 277-5328 Novartis Pharmaceuticals Corporation Secretary: Andy Zaayenga andy.zaayenga@tekcel.com (732) 302-1038 TekCel Corporation Analytical Chemistry Chair and Treasurer: William Haller bhaller@ompus.jnj.com (908) 218-6341 Ortho-McNeil High Throughput Screening Chair: John Babiak, Ph.D. babiakj@war.wyeth.com (732) 274-4788 Wyeth-Ayerst Research Agricultural Applications Chair: Sharon Reed reeds@pt.cyanamid.com (609) 716-2905 American Cyanamid Data Management Chair: Steve Fillers, Ph.D. steve_fillers@biogen.com (617) 679-2657 Biogen Inc. ___________________________________________________________ Directions: The Raritan Valley Community College campus lies at the crossroads of Central New Jersey, with Routes 22, 202 and 206 and Interstates 287 and 78 just minutes away. The College is situated on the north side of Route 28 in North Branch. FROM THE NORTH >From INTERSTATE 287 SOUTH - (From Morristown Area): Take Interstate 287 SOUTH to Interstate 78 WEST. Proceed on 78 WEST for approx. 3 miles to Exit 26 (Lamington/North Branch). At light make a left onto Lamington Road. Proceed on Lamington Road til it ends (approx. 3 miles). At STOP sign make a left onto Route 28 EAST. Entrance to the College will be on your left approx. 1/8 of a mile. >From GARDEN STATE PARKWAY SOUTH - (From North Jersey): Take Exit 142 for Interstate 78 WEST. Proceed on 78 WEST for approx. 26 miles to Exit 26 (Lamington/North Branch). At light make a left onto Lamington Road. Proceed on Lamington Road til it ends (approx. 3 miles). At STOP sign make a left onto Route 28 EAST. Entrance to the College will be on your left approx. 1/8 of a mile. FROM THE SOUTH >From INTERSTATE 287 NORTH - (From Edison Area): Take Interstate 287 NORTH to the Route 22 WEST exit. After ap miles (just before the 5th light), exit onto Orr Drive. At the end of Orr Drive make a left at the STOP sign. Make first right into the College. >From GARDEN STATE PARKWAY NORTH - (From the Shore area): Take Exit 127 to Interstate 287 NORTH. Proceed on 287 NORTH to the Route 22 WEST exit. After approx. 7 miles (just before the 5th light), exit onto Orr Drive. At the end of Orr Drive make a left at the STOP sign. Make first right into the College. >From ROUTE 206 NORTH - (From Princeton Area): Take Route 206 NORTH to the Somerville Circle. At the Somerville Circle exit onto Route 28 WEST. Proceed on Route 28 WEST for approx. 4 miles. Entrance to the College will be on your right. FROM THE EAST >From INTERSTATE 78 WEST - (From Newark Area): Take Interstate 78 WEST. Proceed on 78 WEST and get off at Exit 26 (Lamington/North Branch). At light make a left onto Lamington Road. Take Lamington Road til it ends (approx. 3 miles). At STOP sign make a left onto Route 28 EAST. Entrance to College will be on your left approx. 1/8 of a mile. FROM THE WEST >From INTERSTATE 78 EAST - (From Clinton Area): Take Interstate 78 EAST to Exit 26 (Lamington/North Branch). Turn right at light onto Lamington Road. Proceed on Lamington Road til it ends (approx. 3 miles). At STOP sign make a left onto Route 28 EAST. Entrance to the College will be on your left approx. 1/8 of a mile. FROM OTHER AREAS >From NEW JERSEY TURNPIKE - Take the New Jersey Turnpike to Exit 10. After toll, bear left, exit onto Interstate 287 NORTH. Proceed on 287 NORTH to the Route 22 WEST exit. After approx. 7 miles (just before the 5th light), exit onto Orr Drive. At the end of Orr Drive make a left at the STOP sign. Make first right into the College. >From ROUTE 31 NORTH - Take Route 31 NORTH to Route 202 NORTH. Stay on Route 202 NORTH for approx. 10 miles til you come to the Somerville Circle. At the Somerville Circle exit onto Route 28 WEST. Proceed on Rt 28 WEST for approx. 4 miles. Entrance to the College will be on your right. >From PENNSYLVANIA TURNPIK 22 East to Route 78 East. Follow directions above "FROM THE WEST" (From Clinton Area). FROM THE PARKING LOT Follow signs to parking lot #2. Area Hotels: Ramada Inn 60 Cottontail Lane & Rt. 287 Somerset, NJ  08873 732-560-9880 mention LRIG and get room for $94 Somerset Marriott Hotel 110 Davidson Avenue Somerset, NJ  08873 800-228-9290, 732-560-0500 Best Western 1271 Rt 22 West & 287 Bridgewater, NJ 800-528-1234, 908-722-4840 Days Inn of Hillsborough 118 US Hwy 206 South Somerville, NJ 908-685-9000 Hampton Inn 255 Davidson Avenue Somerset, NJ  08873 908-563-1600 DoubleTree Hotel 200 Atrium Drive Somerset, NJ  08873 732-469-2600 Somerset Hills 200 Liberty Corner Road Warren, NJ  07059 908-647-6700 Summerfield Suites 530 Route 22 East Bridgewater, NJ 08807 908-725-0800 Summerfield Suites Somerset, NJ 732-356-8000 _________________________________________ Visit the Mid Atlantic Chapter homepage at http://lab-robotics.org/Mid_Atlantic/ Visit the Laboratory Robotics Interest Group homepage at http://lab-robotics.org From owner-repertoires@net.bio.net Thu Feb 25 22:00:00 1999 Path: biosci!biosci!not-for-mail From: The Antibody Resource Page Newsgroups: bionet.molecules.repertoires Subject: The Antibody Resource Page Date: 26 Feb 1999 09:53:09 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 54 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <36D54FF6.7534@antibodyresource.com> NNTP-Posting-Host: net.bio.net The Antibody Resource Page (http://www.antibodyresource.com/) is your number one source for information on antibodies. Here is just some of what can be found on the page: 1. Custom Antibodies - a list of online companies that will make custom antibodies for you. 2. Books - a small but growing section on books important to researchers who work with antibodies. Do you sell such books? Let us know and we can post a review. 3. How to Find an Antibody - a variety of ways on and off the web to find the antibody you are looking for. There are links to free search engines that allow you to peruse a multitude of companies for the specific antibody that you need. 4. Online Companies - links to over 130 companies that sell antibodies or antibody related products. Is your company listed on this page? 5. Antibody Image Gallery - see some of the latest in animated and non-animated antibody graphics 6. Bulletin Board - Have a question? Then stop by and post a message. Or answer a question. 7. Educational Resources - a variety of new links have been added.There are links to pages on immunochemistry, antibody production, autoimmunity, vaccines, immunology and much more. This page is divided up into sections on research, educational, and health resources. 8. The latest in antibody news - Get up-to-date, antibody-related news articles and newsgroup discussions 9. Online databanks and databases - links to online protein and nucleic acid sequencing databases. Invaluable to biochemists and molecular biologists who work with antibodies. Check it all out at: http://www.antibodyresource.com/ ps. Don't forget to visit our current sponsors, Diatec (http://www.diatec.com/), Sciquest (http://www.sciquest.com/) and Bethyl Laboratories (http://www.bethyl.com). pps. Are you interested in being a sponsor on the Antibody Resource Page (ARP)? Nearly half of the visitors come to find commercially available antibodies. If you are a company that sells antibodies and want to increase webtraffic to your site, email the antibody resource page to find out about sponsorship: antibody@antibodyresource.com From owner-repertoires@net.bio.net Sun Feb 28 22:00:00 1999 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 1 Mar 1999 02:40:19 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199902281000.CAA21685@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-repertoires@net.bio.net Sun Feb 28 22:00:00 1999 Path: biosci!biosci!not-for-mail From: The Antibody Resource Page Newsgroups: bionet.molecules.repertoires Subject: The Antibody Resource Page Date: 1 Mar 1999 02:38:51 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 54 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <99226181443.~INN-NVAa00160.bionet-news@dl.ac.uk> Reply-To: The Antibody Resource Page NNTP-Posting-Host: net.bio.net The Antibody Resource Page (http://www.antibodyresource.com/) is your number one source for information on antibodies. Here is just some of what can be found on the page: 1. Custom Antibodies - a list of online companies that will make custom antibodies for you. 2. Books - a small but growing section on books important to researchers who work with antibodies. Do you sell such books? Let us know and we can post a review. 3. How to Find an Antibody - a variety of ways on and off the web to find the antibody you are looking for. There are links to free search engines that allow you to peruse a multitude of companies for the specific antibody that you need. 4. Online Companies - links to over 130 companies that sell antibodies or antibody related products. Is your company listed on this page? 5. Antibody Image Gallery - see some of the latest in animated and non-animated antibody graphics 6. Bulletin Board - Have a question? Then stop by and post a message. Or answer a question. 7. Educational Resources - a variety of new links have been added.There are links to pages on immunochemistry, antibody production, autoimmunity, vaccines, immunology and much more. This page is divided up into sections on research, educational, and health resources. 8. The latest in antibody news - Get up-to-date, antibody-related news articles and newsgroup discussions 9. Online databanks and databases - links to online protein and nucleic acid sequencing databases. Invaluable to biochemists and molecular biologists who work with antibodies. Check it all out at: http://www.antibodyresource.com/ ps. Don't forget to visit our current sponsors, Diatec (http://www.diatec.com/), Sciquest (http://www.sciquest.com/) and Bethyl Laboratories (http://www.bethyl.com). pps. Are you interested in being a sponsor on the Antibody Resource Page (ARP)? Nearly half of the visitors come to find commercially available antibodies. If you are a company that sells antibodies and want to increase webtraffic to your site, email the antibody resource page to find out about sponsorship: antibody@antibodyresource.com