From owner-repertoires@net.bio.net Thu Mar 04 22:00:00 1999 Path: biosci!biosci!not-for-mail From: rollin@writeme.com Newsgroups: bionet.molecules.repertoires Subject: '99 ISAAST. Date: 5 Mar 1999 02:49:36 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 57 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <2F58D793.B67DAF8E@writeme.com> NNTP-Posting-Host: net.bio.net '99 International Symposium on Aging and Antiaging Science & Technology (with EXHIBITION) September 8-12, 1999 Beijing, China Scientific Sessions 1. Biological Science 2. Clinical & Experimental Medicine 3. Health Care for the Elderly 4. Traditional Chinese Medicine in Aging & Antiaging Exhibition The companies engaged in producing the instruments or reagents that may facilitate the antiaging researches are welcomed and encouraged to exhibit their high-tech products. For whose interested in the exhibition, please contact us at your earliest convenience. Sponsor Antiaging Science & Technology Society=A3=AC Gerontological Society of Chin= a Organizers Antiaging Science & Technology Society , Gerontological Society of China China International Symposium Center for Sciences and Technology (CICCST) Co-Organizer BILONG Institute for Transgenic Animals in Beijing (BITAB) Supporters Gerontological Society of China Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of medical Sciences Beijing Hospital and Gerontological Research Institute (to be continued) Contact: ********************************************************* BILONG Academic Events Add: 8 Nan Er Jie, Zhong Guan Cun, Beijing 100080, China Box: P.O. Box 8734, Beijing 100080, China Tel: 86-10-6256-0561, 6256-2226 Ext 211, 800-810-0797 Fax: 86-10-6253-2114 Email: BAE@bilong.com ********************************************************* From owner-repertoires@net.bio.net Sun Mar 07 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Guenter Grethe Newsgroups: bionet.molecules.repertoires Subject: Call for Papers "Management of Reaction Information" - ACS New Date: 8 Mar 1999 01:14:42 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 37 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7c03eg$nrh$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Call for Papers The Division of Chemical Information of the American Chemical Society is planning a symposium on "Management of Reaction Information for the Synthetic Chemist" for the Fall ACS Meeting in New Orleans, August 22 - 26, 1999. A similar symposium was held at an ACS National Meeting several years back and in 1997 (Las Vegas ACS) we discussed recent developments in reaction databases. The dramatic increase over the last few years in the size of databases and the shift towards combinatorial chemistry requires new approaches for the effective handling of available information. During the symposium the tools under development or available today to the practicing synthetic chemist for effectively planning the synthesis of an individual compound or a compound library will be discussed. These include reaction retrieval and prediction, available databases, electronic access to the primary literature, post-search data management and others. If you are interested in presenting a paper at this symposium please contact me before April 5th at the address shown below. Abstracts are due April 15th. Sincerely yours, Guenter Grethe Symposium Organizer Dr. Guenter Grethe Director, Scientific Applications Product Development MDL Information Systems, Inc. 14600 Catalina Street, CA 94577 Tel.: (+1) 510-357-2222 ext.1430 Fax: (1) 510-614-3616 e-mail: guenter@mdli.com From owner-repertoires@net.bio.net Sun Mar 07 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. Wendy A. Warr" Newsgroups: bionet.molecules.repertoires Subject: Silicon Graphics NT Workstations Date: 8 Mar 1999 01:11:56 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 19 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7c03be$nq3$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Some time ago I put a message on these lists (excuse duplicates) about the new Silicon Graphics NT workstations. This hardware will be mentioned in a virtual meeting with which I am involved on March 22. I would be very grateful for any suggestions for questions I can put to SGI (I won't broadcast your name!), especially questions from UNIX fans. Reply to wendy@warr.com, not to the whole list, if your answer is private. Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-repertoires@net.bio.net Sun Mar 07 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Robert Clark Newsgroups: bionet.molecules.repertoires Subject: Open position at Tripos Date: 8 Mar 1999 01:07:14 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 22 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7c038i$nlg$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Tripos has an opening for a recent chemistry PhD in its research group to undertake development and evaluation of new methods in QSAR and diversity analyis. Good writing and oral communication skills, creativity and a strong scientific background are all essential. Applicants should have experience with a range of pertinent application packages as well as an understanding of the fundamental analytical principles upon which they are based. Demonstrated programming ability and familiarity with C and/or SYBYL programming language are highly desirable, but the strength of a candidate's analytical ability is more important. A broad chemistry and/or biochemistry background will be a decided plus, as will industrial experience. If interested, please contact: Robert D. Clark 1699 S. Hanley Road St. Louis MO 63144 bclark@tripos.com From owner-repertoires@net.bio.net Tue Mar 09 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Abid Suleri Newsgroups: bionet.molecules.repertoires Subject: Cysteine Proteinases inhibitor bioassay Date: 10 Mar 1999 04:00:04 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 43 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7c5k0v$sq6$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net I am an entomologist with a very little back ground of enzymology. For my PhD research, I am studying the interaction between a seed beetle (Callosobruchus maculatus) and 4 varieties of host legumes. I found that in one of the legume variety the development period of insect is much prolonged. It is known that this insect larvae use cysteine proteinases for digestion. Based on the assumption that the legume variety in which development is prolonged may contain some cysteine proteinase inhibitors, I started my biochemical bioassays. First I was using BAPNA as substrate but could not find any relationship between E-64 and insect midgut enzyme using this substrate. Now I am using Z-Phe-Arg-pNA as a substrate. Extracting crude gut enzyme from 3rd instar larvae and want to get a standard curve using E-64. It is still not giving me any sequence. I got hold of commercially available Cathepsin-B. Now I want to run a reaction, using E-64, substarte, and cathepsin -B to detrmine if the bioassay works at all. Will you please help me in developing any assay. How much Cathepsin should I take and what will be the buffer for it. Any suggestion will be a great help. Thanks Abid --------------------------------------------------- Abid Suleri Food Security Department, B-128, NRI , Chatham Kent, ME4 4TB. Ph :+ 44-(0)1634-883807 Fax :+ 44-(0)1634-890405 Mobile:+ 44-(0)958-425392 qa03@greenwich.ac.uk http://www.pak.org/suleri From owner-repertoires@net.bio.net Mon Mar 15 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Tara Dyson Newsgroups: bionet.molecules.repertoires Subject: Current Opinion in CPNS Investigational Drugs Date: 16 Mar 1999 03:36:15 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 62 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net ANNOUNCING - CURRENT OPINION IN CENTRAL & PERIPHERAL NERVOUS SYSTEM INVESTIGATIONAL DRUGS - A NEW REVIEW JOURNAL FREE SAMPLE COPIES AVAILABLE Current Opinion in Central & Peripheral Nervous System Investigational Drugs is a new bimonthly review journal published by Current Drugs Ltd, which covers all aspects of CPNS investigational drug research. The journal provides a comprehensive and up-to-date source of peer-reviewed information on trends and advances in CPNS drug discovery and development. The scope of coverage will include advances in the understanding of disease etiology, from both a genomic and environmental perspective, new trends and targets in disease treatments, as well as the status of compounds advancing through the clinical trial process. Edited by Michael Williams and Tage Honore, the journal is designed to combat the proliferation of the scientific literature by giving the reader an intelligent overview of the important developments across the entire subject. Its contents are divided into six major sections, each of which is reviewed in turn throughout the year. Pain Neuro-urology Neurodegenerative and cognitive disorders Affective/behavioral/personality disorders and substance abuse Neurology and neuroprotection Schizophrenia and psychosis Contributions from internationally recognized researchers are all invited and peer-reviewed by an Editorial Board of distinguished members of the scientific community. The views of experts in the form of editorial overviews, review articles, drug evaluations, annotated paper and patent coverage are contained in each issue. For further information, see the Current Drugs website http://www.current-drugs.com To request your FREE SAMPLE COPY mailto:cocpnssamp@cursci.co.uk and supply us with your name, company, address, telephone number and email details. Kind regards Tara Dyson Editorial Director Current Drugs Ltd Middlesex House 34-42 Cleveland Street London W1P 6LB UK Tel: +44-171-580-8393 Fax: +44-171-580-5646 Email: tara@cursci.co.uk http://www.current-drugs.com From owner-repertoires@net.bio.net Wed Mar 17 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Ortwine, Dan" Newsgroups: bionet.molecules.repertoires Subject: Call for Papers - "Docking & Scoring" - ACS National Meeting in New Date: 18 Mar 1999 00:54:21 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 44 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7cqe2r$rsu$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Call for Papers The Computers in Chemistry Division of the American Chemical Society is planning a symposium on "Docking and Scoring" for the Fall ACS Meeting in New Orleans, August 22 - 26, 1999. The overall theme is the prediction of ligand/protein binding affinity via compuational means. Individual sessions are planned that will cover a range of methodologies, from the use of fast, empirical scoring functions that can be applied to large databases to select candidates for screening, to more rigorous techniques designed to return accurate assessments of binding energy. Examples of topics expected to be covered include but are certainly not limited to QM/MM methods, molecular dynamics calculations (linear response methods, etc.), as well as more simplified potential functions (potential of mean force, LUDI, SMOG, DOCK scoring, etc.). If you are interested in presenting a paper at this symposium please contact me before April 10th at the address shown below. Abstracts are due April 15th. For your information, the ACS has a new on-line abstract submission procedure available. For details, see http://www.acs.org/meetings/abstract/abinfo.html I look forward to seeing you in New Orleans! Dan Ortwine Symposium Organizer ---------------------------------------------------- Daniel F. Ortwine Senior Research Associate Computer-Assisted Drug Design Parke-Davis Co. Phone: 734-622-7309 2800 Plymouth Road Fax: 734-622-2782 Ann Arbor, MI 48105 email: Dan.Ortwine@wl.com USA From owner-repertoires@net.bio.net Wed Mar 17 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. David Johnson" Newsgroups: bionet.molecules.repertoires Subject: Biochemistry Faculty Position Date: 18 Mar 1999 00:59:43 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 59 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7cqefr$s7t$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Protease Friends, The following is an announcement of an available faculty position in my department. If you are interested, please apply. We will be moving to a new research building in late 2000. This is a beautiful place to live and our new dean is committed to improving our research environment. ------------------------------------------------------------------- EAST TENNESSEE STATE UNIVERSITY Biochemistry & Molecular Biology Department Johnson City, Tennessee 37614-0581 Assistant/ Associate Professor of Biochemistry and Molecular Biology- The Department of Biochemistry and Molecular Biology of the James H. Quillen College of Medicine, East Tennessee State University (ETSU), seeks a new faculty member. The appointment will preferably be at the Assistant Professor level although exceptional individuals will be considered for appointment as Associate Professor. The position is tenure-track and comes with a competitive salary, laboratory space and start-up package. The successful candidate must hold a doctoral degree (Ph.D. and/or M.D.) and provide evidence of highly productive prior research experience. An important area for research development, in the department, is vascular molecular biology. Applicants who are specifically working in the area of atherogenesis will be given preference. However, individuals who are currently working on basic aspects of cellular signaling mechanisms, or regulation of gene expression, and are interested in developing collaborative studies of atherogenesis also will be considered. The location of the James H. Quillen College of Medicine is Johnson City, TN, a pleasant community situated between the Blue Ridge and Great Smoky Mountains. The region offers numerous opportunities for outdoor recreation. Review of applications will begin on April 1 and will continue until the position is filled. Send a description of current research, representative reprints of published work, a curriculum vita, and names and addresses of three references to: Dr. Michael Sinensky, Chair, Biochemistry and Molecular Biology, East Tennessee State University, Box 70581, Johnson City, TN 37614-0581. ETSU is an Affirmative ActionlEqual Opportunity employer. Women and minorities are encouraged to apply. ------------------------------------------------------------ Dave David A. Johnson, Ph.D. Professor Dept. of Biochem.nd Mol. Biol. Quillen College of Medicine East Tennessee State University Johnson City, TN 37614-0581 Phone (423) 439-6273 Fax (423) 975-8235 From owner-repertoires@net.bio.net Wed Mar 17 22:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. Wendy A. Warr" Newsgroups: bionet.molecules.repertoires Subject: Warr pages updated Date: 18 Mar 1999 00:58:34 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 29 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7cqed0$s3g$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Colleagues, Please excuse duplicate postings. We have done a significant amount of updating at http://www.warr.com. If you have not visited recently, do have a look. In addition you might like to have a virtual breakfast with me at 8am PST (4 pm GMT) on March 21, 22, 23 or 24. It's free! Enjoy it over afternoon tea instead of breakfast if you're in the UK. Sunday's show is an introduction to the National ACS meeting. Monday's show concerns molecular modeling. Tuesday's is about combinatorial chemistry in materials science/catalysis and Wednesday's is a surprise package. Further details are at the registration site http://chemweb.vei.co.uk (pick Event 15). Do please join in - it's much more interesting when we get a big [virtual] audience. Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-repertoires@net.bio.net Wed Mar 17 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Steve Heller Newsgroups: bionet.molecules.repertoires Subject: ChemInt'99 - Web Abstract Submission Form Now Operational Date: 18 Mar 1999 00:55:58 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 65 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7cqe9p$s2n$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net This note is to announce that web Abstract Submission form is now operational for the Chemistry and the Internet (ChemInt'99) meeting being held in at Georgetown University in Washington DC on September 25-27, 1999. The program of invited speakers and panel members of the 3 panel sessions is available on the meeting web site - www.chemint.org You are urged to look at the program and to consider submitting a poster paper to the meeting. A number of poster papers will be selected for oral presentation at the meeting. The main lecturers for the meeting will be: Alan Arnold, University College (UNSW) Steven Bachrach, Northern Illinois University Robert Bovenschulte, ACS Stephen Boyer, IBM Karl Harrison, Oxford University Clemens Jochum, Deutsche Bank Gary Mallard, NIST Tom Pierce, Rohm & Haas Jerome Reichman, Vanderbilt Achim Zielesny, Bayer AG Steven S. Zumdahl, University of Illinois at Urbana-Champaign The (current) corporate sponsors for the meeting are: ChemWeb and the Internet Journal of Chemistry Technical Sponsors are: ACS CINF Division ACS COMP Division The Chemical Structure Association (CSA) Georgetown University - Department of Chemistry International Union of Pure and Applied Chemistry (IUPAC) (pending) Japan Association for International Chemical Information (JAICI) Special Libraries Association (SLA) Chemistry Division Royal Society of Chemistry (RSC) Steve Heller Steve Heller, Guest Researcher NIST/SRD, Mail Stop: 820/113 820 Diamond Avenue, Room 101 Gaithersburg, MD 20899-2310 USA E-mail: chem@feldmann.nist.gov From owner-repertoires@net.bio.net Wed Mar 24 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Kim Takita Newsgroups: bionet.molecules.repertoires Subject: Materials Informatics Date: 25 Mar 1999 10:05:18 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 43 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7dd2rf$4fb$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net "Effective Data Management for New Materials Discovery: Materials Informatics" June 28-29, 1999 in Boston, MA for more information see our web site: http://www.knowledgefoundation.com/informatics.html or email kmtakita@knowledgefoundation.com and we will mail you a full brochure. The conference covers many of the issues brought up in the group. Some of these questions include: * How to design multiple materials databases to allow transparent acess to all relevant applications throughout the discovery to development phase * How to integrate disparate application software, and provide standardized methods of analyzing data * How to enlist the aid of software and systems providers * How to best access publicly available information sources IN addition, a special session will be held in conjunction with the conference to explore the establishment of an industry consortium for materials informatics. Please feel free to contact me for further information. Sincerely, Kim ------------------------------------------------ Kim Takita Vice President The Knowledge Foundation, Inc. 101 Merrimac Street Boston, MA 02114 617-367-7979 ext. 202 617-367-7912 (fax) Email: kmtakita@knowledgefoundation.com http://www.knowledgefoundation.com From owner-repertoires@net.bio.net Wed Mar 24 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Dori Luzbetak Newsgroups: bionet.molecules.repertoires Subject: MDL INTRODUCES CHESHIRE FOR ISIS Date: 25 Mar 1999 10:03:09 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 142 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7dd2js$49s$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net CONTACT: Corbin Collins MDL Information Systems, Inc. (510) 895-1313, ext. 1371 corbin@mdli.com http://www.mdli.com European mirror site: http://www.mdli.co.uk MDL INTRODUCES CHESHIRE FOR ISIS, A CHEMICAL INTERPRETATION ENVIRONMENT FOR INDUSTRY-LEADING ISIS --Companies Can Create Cheminformatics Business Rules, Automate the Analysis and Manipulation of Large Volumes of Chemical Information-- SAN LEANDRO, California--March 17, 1999--MDL Information Systems, Inc. today introduced Cheshire, a sophisticated chemical representation component that tightly integrates a powerful chemical scripting language into the industry-standard ISIS (Integrated Scientific Information System) framework. Cheshire provides a software development environment for building abstract and complex business rules that automate the analysis and interpretation of chemical structures and that calculate chemical information from chemical structures. The system is designed for chemical registration, data mining, property prediction, and sophisticated chemical representation controls within custom cheminformatics applications. Cheshire runs on both client and server platforms within the ISIS family of products, and is portable to future MDL architectures. MDL will demonstrate Cheshire at the meeting of the American Chemical Society, March 22-24, booth 819, Anaheim Convention Center. Cheshire includes Cheshire Studio, an interactive prototyping environment that developers can use to build, edit, and run scripts executed by the Cheshire runtime environment, the workhorse of the Cheshire system. The Cheshire runtime environment is exposed to users and developers directly through several programs in the ISIS family of products--ISIS/Base, ISIS/Object Library, ISIS for Microsoft Excel, ISIS/Host Application Program Interface (API), ISIS Procedural Language (PL), and Chemscape. This accessibility allows Cheshire to plug-and-play with existing discovery systems and support the breadth of scientific applications used within the pharmaceutical, chemical, and biotech industries. Cheshire enables high-level functions that can operate on entire collections of atoms and bonds, not just individual atoms and bonds. For the developer, this high-level abstraction makes the scripting language intuitive and easy to program. For the end user, the abstraction enables high-level operations such as exploring molecular fingerprints to aid in structure-activity relationship studies. Cheshire's scripting language is modeled on Javascript, allowing the use of familiar programming constructs such as objects, methods, and properties. Cheshire comes standard with a library of sample scripts, including a part of the chemical representation conversion rules MDL uses when building databases such as the Available Chemicals Directory. The system also comes with valuable example utilities, including an ISIS/Base add-in that provides scientists working in ISIS/Base off-the-shelf access to Cheshire capabilities. Users can extend ISIS/Base immediately with a sophisticated chemical interpretation component to calculate physicochemical data from structures, which helps scientists analyze chemical structures that would otherwise require tedious manual inspection. "In our view, Cheshire is based on a set of abstract concepts including 'collections' and 'mappings' within an object-oriented framework," said Dr Upali Bandara, business analyst, ZDW Scientific Information, BASF Aktiengesellschaft. "The combination of these concepts with the rich dictionary of basic operations allows Cheshire to cover all the business rules we need in the process of structure registration. The Cheshire Studio will help us to do the programming and testing in a remarkably efficient way." "Cheshire fits into multiple discovery environments where different scientists and programmers can use it to automate tasks related to in-depth chemical structure processing in numerous ways," said Rudy Potenzone, senior vice president of product development at MDL. "The system's robust chemical intelligence and its sophisticated methods for analyzing and interpreting chemistry not only enhance core ISIS products but interoperate easily in a variety of ways with other MDL systems. We designed Cheshire to help research organizations build a comprehensive and integrated discovery informatics framework." The ISIS Family and Complementary Systems For the past seven years, ISIS solutions have provided an information management architecture that supports the registration, retrieval, display, and analysis of all types of scientific information. Pharmaceutical, biotech, agrochemical, and chemical industries worldwide use ISIS applications, which support compound-discovery research and development. Cheshire works with * ISIS/Draw, a chemically intelligent drawing program * ISIS/Base, a forms-based desktop database management system and/or client for querying and accessing corporate data sources through ISIS/Host * ISIS/Object Library, an OLE interface to ISIS on the client * ISIS/Host API, a programmable interface to the ISIS/Host integration engine on the server * ISIS/PL, a programming language within ISIS on the client and the server * ISIS for Microsoft Excel, a data analysis tool that combines the spreadsheet environment of Excel with the chemical structure handling capabilities of ISIS * Chemscape, a Web-based system that provides complete ISIS structure and data searching capabilities from within Web browsers Cheshire also integrates with other MDL products, including * Reagent Selector, MDL's new system for selecting and obtaining reagents * Central Library, MDL's solution for combinatorial chemistry * The Spotfire product suite, systems for the interactive visualization of large data sets and chemical structures About MDL MDL Information Systems, Inc. is the recognized leader in discovery informatics for the life science and chemical industries. MDL software, content, and services provide the enterprise framework for identifying successful new products. A wholly owned subsidiary of Elsevier Science, MDL has offices worldwide with headquarters in San Leandro, California. ### Chemscape and MDL are registered trademarks and Available Chemicals Directory, Central Library, Cheshire, ISIS, ISIS/Object Library, and Reagent Selector are trademarks of MDL Information Systems, Inc. Microsoft is a registered trademark of the Microsoft Corporation. Spotfire is a registered trademark of Spotfire, Inc. All other product names may be registered trademarks or trademarks of their respective holders. Dori Luzbetak Web Communications Manager Marketing Communications MDL Information Systems, Inc. 14600 Catalina Street San Leandro, CA 94577 (510) 895-1313 x1652 (510) 614-3608 - FAX dori@mdli.com From owner-repertoires@net.bio.net Wed Mar 24 22:00:00 1999 Path: biosci!biosci!not-for-mail From: rollin@writeme.com Newsgroups: bionet.molecules.repertoires Subject: '99 BWTI. Date: 25 Mar 1999 07:01:31 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 30 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <2F71D663.ADD146E7@writeme.com> NNTP-Posting-Host: net.bio.net '99 BILONG WORKSHOP ON TRANSPLANTATION IMMUNOLOGY August 18-20, 1999 Beijing, China Topics: 1. Prevention and Treatment of Allograft Rejection 2. Preventation and Treatment of Xenograft Rejection 3. Application and Prospect of Transgenic Animal in Xenotransplantation 4. Application of Immunosuppressive Agents in Transplantation Invited Speakers: Prof. Guo Zhangzhan, Beijing Medical University Prof. Zhu Naishuo, Fudan University. Major Histocompatibility Complex (MHC) DNA typing and tissue matching in allograft (continued) Contact: ********************************************************* BILONG Transgenics----A Creative Group for Transgenics Add: 8 Nan Er Jie, Zhong Guan Cun, Beijing 100080, China Box: P.O. Box 8734, Beijing 100080, China Tel: 86-10-6256-0561, 6256-2226 Ext 211, 800-810-0797 Fax: 86-10-6253-2114 Email: info@bilong.com Internet: www.bilong.com ********************************************************* From owner-repertoires@net.bio.net Wed Mar 24 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Charles Kessler Newsgroups: bionet.molecules.repertoires Subject: New online drug discovery resource Date: 25 Mar 1999 10:13:22 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 24 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7ddt9a$n3u$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Drug Discovery Online is an internet community, for scientists, executives, and professionals in the drug discovery industry. http://www2.drugdiscoveryonline.com/welcome/ngmdck The site is anchored by managing editor, Angelo DePalma, and contains industry news, feature articles, case studies, newsletters, chats, employment opportunities, an events calendar, discussion forums and more. Charles Kessler ckessler@drugdiscoveryonline.com 888-680-3223 C h a r l e s K e s s l e r & A s s o c i a t e s Online Marketing Services since 1994 888-680-3223 http://www.microsoft.com/smallbiz/success/charleskessler.htm The Cool Tricks and Trinkets Newsletter http://www.tricksandtrinkets.com/ From owner-repertoires@net.bio.net Wed Mar 24 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Michel Calderini Newsgroups: bionet.molecules.repertoires Subject: Argopore and IRORI Date: 25 Mar 1999 10:09:25 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 28 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7ddifk$hma$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Does somebody use the Argopore resin with IRORI-microkans? If yes, could you tell me something about advantages and drawbacks of these resins. Best Regards Michel Calderini _______________________________________________ Michel CALDERINI Merck KGaA A19/111 - Med Chem ZNS Frankfurterstrasse 250 D-64293 DARMSTADT Tel: (49) 6151 728372 Germany Fax: (49) 6151 723129 E-mail: Michel.Calderini@merck.de Any opinion in this mail does not necessarily match the views of Merck KGaA! _______________________________________________ From owner-repertoires@net.bio.net Wed Mar 24 22:00:00 1999 Path: biosci!biosci!not-for-mail From: Kim Takita Newsgroups: bionet.molecules.repertoires Subject: Rational Approaches to Materials Design & Synthesis Date: 25 Mar 1999 10:08:10 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 42 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7dd2ol$4ac$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net International Conference on Rational Approaches to Materials Design & Synthesis May 20-21, 1999 in Philadelphia. see our web site for more information: http://www.knowledgefoundation.com/rational.html or email kmtakita@knowledgefoundation.com with your mailing address and we will mail you a full brochure. Emphasis will be placed on approaches through practical examples on how to effectively: * Target new materials by design * Accelerate discovery through rational design and selective synthesis * Define computational & modeling requirements Just a few organizations represented on program faculty include Universal Oil Products, Eastman-Kodak, Air Products & Chemicals, Symyx Technologies, Exxon Research & Engineering, Mobil Technology as well as leading academic researchers. Please feel free to contact me if you would like further information. Sincerely, Kim ------------------------------------------------ Kim Takita Vice President The Knowledge Foundation, Inc. 101 Merrimac Street Boston, MA 02114 617-367-7979 ext. 202 617-367-7912 (fax) Email: kmtakita@knowledgefoundation.com http://www.knowledgefoundation.com From owner-repertoires@net.bio.net Mon Mar 29 23:00:00 1999 Path: biosci!biosci!not-for-mail From: FLO Newsgroups: bionet.molecules.repertoires Subject: Metal Carbenes in Organic Synthesis Date: 30 Mar 1999 08:59:28 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 33 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7dqsd1$nfk$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net Hello, 'Metal Carbenes in Organic Synthesis' by F. Zaragoza has just appeared. (Wiley-VCH, 265 pages, 1433 references, ISBN 3-527-29625-5). I have discussed all aspects of carbene complex chemistry in detail, with special emphasis on recent innovations. Some of the main topics are olefin metathesis, cyclopropanation, benzannulation, etc. The applications of metathesis to solid-phase synthesis are also covered, e.g. the release of compounds from solid supports by ring-closing metathesis or the preparation of alkenes on solid-phase by cross-metathesis. More information is available at: http://www.wiley-vch.de/books/tis/eng/3-527-29625-5.html http://www.thebookplace.co.uk http://www.bookshop.co.uk I really hope this resource will give you a lot of inspiration and be a valuable reference for everybody interested in applications of transition metals in organic synthesis. Best regards Florencio Zaragoza From owner-repertoires@net.bio.net Mon Mar 29 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Tara Dyson Newsgroups: bionet.molecules.repertoires Subject: Current Opinion in Anti-infective Investigational Drugs Date: 30 Mar 1999 08:56:56 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 61 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7dqr6h$mom$1@mserv2.dl.ac.uk> NNTP-Posting-Host: net.bio.net ANNOUNCING - CURRENT OPINION IN ANTI-INFECTIVE INVESTIGATIONAL DRUGS - A NEW REVIEW JOURNAL FREE SAMPLE COPIES AVAILABLE Current Opinion in Anti-infective Investigational Drugs is a new bimonthly review journal published by Current Drugs Ltd, which covers all aspects of anti-infective investigational drug research. The journal provides a comprehensive and up-to-date source of peer-reviewed information on trends and advances in therapies for bacterial, viral, fungal and parasitic infectious diseases. In addition, expert commentaries on the scientific and commercial potential of selected drugs in clinical trials are provided in each issue. Edited by Jacob Plattner, Erik De Clercq and Daniel Chu, the journal is designed to combat the proliferation of the scientific literature by giving the reader an intelligent overview of the important developments across the entire subject. Its contents are divided into six major sections, each of which is reviewed in turn throughout the year. Antibacterials (glycopeptides, beta-lactams plus other agents) Antivirals (HIV) Antifungals Antibacterials (quinolones, macrolides and oxazolidinones) Antivirals (non-HIV) Antiparasitics Contributions from internationally recognized researchers are all invited and peer-reviewed by an Editorial Board of distinguished members of the scientific community. The views of experts in the form of editorial overviews, review articles, drug evaluations, annotated paper and patent coverage are contained in each issue. For further information, see the Current Drugs website http://www.current-drugs.com To request your FREE SAMPLE COPY mailto:coinfectsamp@cursci.co.uk and supply us with your name, company, address, telephone number and email details. Kind regards Tara Dyson Editorial Director Current Drugs Ltd Middlesex House 34-42 Cleveland Street London W1P 6LB UK Tel: +44-171-580-8393 Fax: +44-171-580-5646 Email: tara@cursci.co.uk http://www.current-drugs.com From owner-repertoires@net.bio.net Mon Mar 29 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Yoshihisa Inoue Newsgroups: bionet.molecules.repertoires Subject: The 8th Meeting of Japan Combinatorial Chemistry Group (JCCF8) Date: 30 Mar 1999 02:38:45 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 108 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199903300403.NAA00333@terra.yoshitomi.co.jp> NNTP-Posting-Host: net.bio.net Dear Netters, We are pleased to announce that Japan Combinatorial Focus Group, JCCF, will hold the 8th JCCF Meeting on April 26-27 at Senri Life Science Center in Osaka, Japan. And we have to say sorry that if you want to present your products at the booths, all the 30 booths are occupied already. Please try next meeting in Tokyo in November. **************************************************************** 8th Meeting of Japan Combinatorial Chemistry Focus Group **************************************************************** April 26-27 Senri Life Science Center, Osaka, Japan April 26 10:00 opening 10:10-11:00 IL-1 Hirohisa Shindo (Shionogi & Co.,Ltd.) Development of high speed lead optimization using molecular diversity and parallel synthesis 11:00-11:20 O-1 Sally Rose (Biofocus) Integrating synthetic and computational chemistry for library design 11:20-11:40 O-2 T. S. Haque1, A. G. Skillman2, C. E. Lee1, H. Habashita1*, I. Y. Gluzman3, T. J. A. Ewing2, D. E. Goldberg3, I. D. Kunz2, J. A. Ellman 1(1. University of California, Berkeley; 2. University of California, San Francisco; 3. Washington University) Directed combinatorial library of aspartyl protease inhibitors. Application to discovery of non-peptide inhibitors of malarial aspartyl protease plasmepsin II. (Lunch) (Vendor Demonstration) 13:30-14:20 IL-2 Kazuhisa Sugimura (Kagoshima University) Peptide mimics of the CTLA4 or CCR5-binding domain and their biological functions 14:20-14:40 O-3 Yasuyuki Shimohigashi (Kyushu University) Sturucture-activity Studies of Phospholipase A2 Inhibitors Based on Peptide Library 14:40-15:00 O-4 Shinji Nagai (Hitachi, Ltd.) Work flow of combinatorial synthesis using liquid synthesis and parallel purifier 15:00-15:20 O-5 Michiko Kanai* (Nihon Waters K.K.), Andrew Brailsford and Chris Chumsae (Waters Corporation) Mass-directed auto purification and characterization of combinatorial libraries 15:50-16:40 IL-3 Anthony D. Piscopio (Array BioPharma) New methods for the high speed parallel synthesis of functionalized heterocycles 16:40-17:00 O-6 Patrick Coffey (Dyax Corporation, Biotage Division) High throughput organic chemistry (HTOC): An automated system for purifying, characterizing and quantifying products of automated synthesis 17:00-17:50 IL-4 Shu Kobayashi (University of Tokyo) Organic synthesis for library construction 18:00- mixer April 27 9:30-10:20 IL-5 Tsutomu Nakamura (Osaka National Research Institute, AIST), Masahiro Iwakura (National Institute of Bioscience and Human Technology, AIST) Discrimination of structural and functional elements in proteins by circular permutation analysis 10:20-10:40 O-7 Yoshihiro Ito (Nara Institute of Science and Technology) Extension of in vitro selection to creat new kinds of aptamers and aptazymes 10:40-11:00 O-8 Jason Armstrong (HTS Consulting Ltd.) Comparisons of HTS mRNA assays that are alternatives to reporter assays, including their implementation of automation. 11:00-11:50 IL-6 Sung-eun Yoo (Korea Research Institute of Chemical Technology) Design of new linkers and a new analytical methodology for combinatorial chemistry (Lunch) (Vendor Demonstration) 13:50-14:10 O-9 Takayuki Doi, Ichiro Hijiguro*, Takashi Takahashi (Tokyo Institute of Technology) An efficient solid phase synthesis of the vitamin D3 system 14:10-15:00 IL-7 Jonathan A. Ellman (University of California, Berkeley) Design, synthesis and evaluation of small molecule libraries 15:00-15:20 O-10 Yasuhiro Uozumi, Tetsu Nakane*, H. Peter Nestler, Rosemarie Sherlock, Ruiping Liu (Nagoya City University, Cold Spring Harbor Laboratory) A combinatorial approach to enantioselectors for axially chiral phosphines. 15:20-15:40 O-11 Clare Ruddick (Mettler Toledo Myriad) High performance automated synthesis successful advanced chemistry in an integrated system 15:40-16:30 IL-8 Chi-Huey Wong (The Scripps Research Institute) Libraries of carbohydrates and carbohydrate mimetics 16:30- closing For details, please see the JCCF homepage. The URL is http://www.orgsyn.riken.go.jp/CombiChem.html. FAX:+81(Japan)-6-6443-6685 Email: jccf@yo.rim.or.jp \ / _ / / Yoshihisa INOUE, Yoshitomi Pharcaceut.Ind., Ltd. \ / / / / 2-25-1 Shodai-Ohtani,Hirakata,Osaka 573-1153 JAPAN / ____/ / tel: +81-720-56-9328 / / / fax: +81-720-68-9597 _/ __/ __/ E-mail: inouey@yoshitomi.co.jp From owner-repertoires@net.bio.net Wed Mar 31 23:00:00 1999 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 1 Apr 1999 03:40:47 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 236 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199903281000.CAA19317@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms.