From owner-repertoires@net.bio.net Thu Apr 01 23:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. Wendy A. Warr" Newsgroups: bionet.molecules.repertoires Subject: Warr Zone Date: 2 Apr 1999 08:15:36 -0800 Organization: Wendy Warr & Associates Lines: 27 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Apologies for multiple postings. Judging from comments I received at the ACS Meeting last week, very few people realize that in January 1999 Warr Zone moved to http://www.warr.com. Headings from the latest Warr Zone are: Hewlett Packard Announces Split Full Text of Patents Through Espacenet Medical Information on the Internet Sagian Introduces SAMI NT Deal between IRORI and Ontogen Universal Language System for Internet Forecast for World's Chemical Markets News from the European Information Industry Do take a look. Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-repertoires@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Bob Snyder Newsgroups: bionet.molecules.repertoires Subject: Second Call For Papers - Combinatorial Chemistry Informatics at ACS Date: 7 Apr 1999 04:15:39 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 71 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net The Chemical Information (CINF) Division is planning a series of sessions on Combinatorial Chemistry Informatics at the fall ACS meeting in New Orleans (August 1999). Each session will focus on a different aspect in the combinatorial chemistry process: from library design, virtual library analysis, and automated synthesis, through high-throughput screening. The four sessions will be presented sequentially to preserve the natural workflow. Abstracts should be submitted electronically by April 15, 1999 by accessing the URL http://207.244.115.201/acs/218nm/cinf/papers/index.cgi If you need more information on one of the sessions contact the session organizer at the end of each session description below. Combinatorial Chemistry Informatics: Library Design Library design can be the most critical aspect in determining the success or failure of the resulting combinatorial library. Selection of the scaffold and R-groups (reagents) can have a profound effect on how well the library members bind to the desired target receptor. Information-based approaches to the design of combinatorial libraries is resulting in smaller, more effective libraries. This session will present novel techniques for library design and registration. Please contact Bob Snyder (bobs@mdli.com) for further information and submission of abstracts. Combinatorial Chemistry Informatics: Virtual Library Analysis/Diversity Assessment This session will focus on the creation and analysis of virtual combinatorial libraries as a means for pre-screening libraries prior to their synthesis. Various diversity measurements will be presented and their effectiveness measured. Please contact Bob Snyder (bobs@mdli.com) for further information and submission of abstracts. Combinatorial Chemistry Informatics: Automated Synthesis and Validation This session will cover information management and tracking methods for all steps of medium or high throughput synthesis. This includes experimental set-up, synthesis techniques, purification methods for synthesized compounds, analytical methods for compound verification, and registration of validated compounds. Speakers from industry, academia, or government who can describe approaches to information management for these issues as applied to their own research programs are preferred. Please contact Terry Wright (terryw@mdli.com) for further information and submission of abstracts. Combinatorial Chemistry Informatics: High-Throughput Screening Combinatorial libraries pose unique challenges to software programmers and developers who provide informatics programs for the drug discovery industry. These challenges include controlling robotic workstations used to create the libraries as well are register and validate the libraries before they are run in High-Throughput Screening (HTS) programs. This sessions will focus on how the presenters companies are dealing with this issue. Please contact Ron Delmendo (rond@mdli.com) for further information and submission of abstracts. Please submit your talks as soon as possible since each session will be limited to one half day. ------------------------------------- Robert W. Snyder, Ph.D. Director, Chemistry Marketing MDL Information Systems email: bobs@mdli.com telephone: 510-895-1313 Never stop searching. From owner-repertoires@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: "Ortwine, Dan" Newsgroups: bionet.molecules.repertoires Subject: Second Call for Papers - "Docking & Scoring" - ACS New Orleans - Fall Date: 7 Apr 1999 04:23:06 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 48 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Second Call for Papers The Computers in Chemistry Division of the American Chemical Society is planning a symposium on "Docking and Scoring" for the Fall ACS Meeting in New Orleans, August 22 - 26, 1999. The overall theme is the prediction of ligand/protein binding affinity via compuational means. Individual sessions are planned that will cover a range of methodologies, from the use of fast, empirical scoring functions that can be applied to large databases to select candidates for screening, to more rigorous techniques designed to return accurate assessments of binding energy. Examples of topics expected to be covered include but are certainly not limited to QM/MM methods, molecular dynamics calculations (linear response methods, etc.), as well as more simplified potential functions (potential of mean force, LUDI, SMOG, DOCK scoring, etc.). If you are interested in presenting a paper at this symposium please contact me before April 10th at the address shown below. Abstracts are due April 15th. For your information, the ACS has a new on-line abstract submission procedure available. For details, see http://www.acs.org/meetings/abstract/abinfo.html If you need more detail, feel free to contact me at the address below. I look forward to seeing you in New Orleans! Dan Ortwine Symposium Organizer ---------------------------------------------------- Daniel F. Ortwine Senior Research Associate Computer-Assisted Drug Design Parke-Davis Co. Phone: 734-622-7309 2800 Plymouth Road Fax: 734-622-2782 Ann Arbor, MI 48105 email: Dan.Ortwine@wl.com USA ---------------------------------------------------- From owner-repertoires@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Guenter Grethe Newsgroups: bionet.molecules.repertoires Subject: Second Call for Papers - "Management of Reaction Information for the Date: 7 Apr 1999 04:20:44 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 47 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net The Division of Chemical Information of the American Chemical Society is planning a symposium on "Management of Reaction Information for the Synthetic Chemist" for the Fall ACS Meeting in New Orleans, August 22 - 26, 1999. A similar symposium was held at an ACS National Meeting several years back and in 1997 (Las Vegas ACS) where recent developments in reaction databases were discussed. The dramatic increase over the last few years in the size of databases and the shift towards combinatorial chemistry requires new approaches for the effective handling of available information. During the symposium the tools under development or available today to the practicing synthetic chemist for effectively planning the synthesis of an individual compound or a compound library will be discussed. These include reaction retrieval and prediction, available databases, electronic access to the primary literature, post-search data management and others. The use of available programs to manage the very large amount of information now available should be stressed. Questions such as "How can infrequent users get the most relevant answers to solve their problems?" and "How can electronic tools mimick the way chemists are now getting their answers from a variety of sources (hardcopies)?" should be answered. A critical look at existing problems and possible solutions would enhance the value of the presentation. Abstracts should be submitted electronically by April 15, 1999 by accessing the URL http://207.244.115.201/acs/218nm/cinf/papers/index.cgi If you need more information about the symposium contact me at the address given below. Dr. Guenter Grethe Director, Scientific Applications Product Development MDL Information Systems, Inc. 14600 Catalina Street, CA 94577 Tel.: (+1) 510-357-2222 ext.1430 Fax: (1) 510-614-3616 e-mail: guenter@mdli.com From owner-repertoires@net.bio.net Tue Apr 06 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Fran Martin Newsgroups: bionet.molecules.repertoires Subject: Updated TSCA + SARA III CD-ROM Date: 7 Apr 1999 04:18:58 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 22 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Environmental health & safety professionals may find this reference useful: The updated U.S EPA Toxic Substance Control Act (TSCA) Chemical Inventory of 62,000 chemicals is available cross-referenced with SARA Title III RCRA reporting requirements on CD-ROM. It features SARA III fields integrated with TSCA information; select U.S. Code Chapters; CORR with TSCA 4, 5, 6, 8, and 12b (export) cross-references; EPA PMN; Canadian DSL/NDSL; European ELINCS; and Adobe(R) Acrobat(R) (PDF) format for instant search/retrieval. For details see http://www.env-sol.com/solutions/TSCASARA.HTML Fran Martin FM Research & Consulting From owner-repertoires@net.bio.net Sun Apr 11 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Andrew Wallace Newsgroups: bionet.molecules.repertoires Subject: New Permanent Lectureships at QUB, Ireland Date: 12 Apr 1999 03:43:05 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 112 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net THE QUEEN'S UNIVERSITY OF BELFAST INVESTING IN EXCELLENCE As part of a major programme of expansion, the University is supporting the School of Biology and Biochemistry with a major investment of posts to enhance its research and teaching activities. The School wishes to appoint people with a record of publications in quality, peer-reviewed journals, commensurate with age and experience. It is also looking for a lively and innovative teaching capability as part of the University's policy of balanced excellence. Three Lectureships (Ref: 99/P141C) Applications are invited from individuals with strong research records and preferably, with some experience in tertiary level teaching in the following areas: Behaviour / Ecology Preferably with interests in: Animal Behaviour Animal Ecology/Conservation Biology Ecological Modelling Physiology/Ecology of Aquatic Animals Biochemistry Preferably with interests in: Molecular Recognition/Structure Prediction Molecular Enzymology Neurochemistry Signal Transduction Genetics/Molecular Biology Preferably with interests in: Behavioural Genetics Microbial Biotechnology Molecular Biology of Infectious Diseases Molecular Evolution/Bioinformatics 2 Year Fixed Term Lectureship in Molecular Ecology and Evolution (Ref: 99/P142C) Preferably with interests in: Population Genetics Eukaryote Genetics Molecular Evolution Applicants must have an honours degree or equivalent in Biological Sciences or related discipline and a PhD in a relevant area together with a good track record of publications in premier scientific journals. Potential to obtain external funding and lead a team of researchers having impact nationally and internationally is essential for the three lectureships. The successful applicant for the fixed term lectureship must be able to contribute to lectures and practicals, and to supervise final year projects in the areas of population genetics, eukaryote genetics and molecular evolution. Successful candidates will be expected to develop independent research programmes complementing and collaborating with other members of the School of Biology and Biochemistry and the wider research community at Queen's and establishing strong national and international links. The successful candidates must also be committed to research-led teaching and preferably have some experience of lecturing and/or practical demonstration and/or supervision of student projects. Postdoctoral experience and a proven ability to acquire external funds are also desirable. Informal enquiries may be made to the School Office, Tel: 00 44 1232 335786 or email:sobb@qub.ac.uk Further information about the School can be obtained on its Home Web page: http://www.qub.ac.uk/bb Salary: Lecturer Grade A 16,655 - 21,815 Pounds Sterling, Lecturer Grade B 22,726 - 29,048 Pounds Sterling, with eligibility for USS and relocation where appropriate. The appointment level will depend on qualifications, research record and experience. The University reserves the right to appoint more than one candidate to a particular area. Closing date: 5.00 pm, Friday 14 May 1999. Further particulars quoting reference number(s) are available from Personnel Office, The Queen's University of Belfast, Northern Ireland, BT7 1NN. Tel: (01232) 273044 or 273854 (answering machine). Fax: (01232) 324944 or email:personnel@qub.ac.uk Committed to an Equal Opportunities policy and selection on merit, the University welcomes applications from all sections of the community. ------------------------------------------------------------------ Andrew Wallace, Ph.D. School of Biology and Biochemistry, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland (UK). Tel. : +44 (0)7074 226373 Fax : +44 (0)7074 426373 Email: a.wallace@qub.ac.nospam.uk (remove "nospam" to email me) WWW : http://www.qub.ac.uk/bb/wallace.html From owner-repertoires@net.bio.net Sun Apr 11 23:00:00 1999 Path: biosci!biosci!not-for-mail From: "Dr. Wendy A. Warr" Newsgroups: bionet.molecules.repertoires Subject: New on Warr Zone Date: 12 Apr 1999 03:19:05 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 20 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Latest headings on Warr Zone http://www.warr.com/warrzone.htm New Web Site for Chemical Design CS Catalyst Becomes ChemNews.Com Adept Science WebStore ComGenex and Bayer: Combinatorial Chemistry Agreement Bioreason Signs Software Development Agreement With Parke-Davis New Deals for Symyx A. Kos Consulting & Solutions Founded Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-repertoires@net.bio.net Sun Apr 11 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Michael Sherrell Newsgroups: bionet.molecules.repertoires Subject: LC/MS et al Date: 12 Apr 1999 02:24:39 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 46 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <01BE83F1.EF992260@oak-hiper1b-82-82.dialup.slip.net> NNTP-Posting-Host: net.bio.net Newly available LC/mass spectrometers: Finnigan Navigator,18 months old; factory refurbished and installed = with 90-day warranty included, $75,000. Micromass Platform II LC/MS, 1994, electrospray & APCI, = Micromass-certified, LC included, $70,000 VG Quattro GC/LC-MS/MS, 1993, 4000 amu, EI/CI, LSIMS, ESI and APCI, = working in lab now, price negotiable IonSpec MALDI FT-MS hi-res hi-sensitivity 1995 model; "most = sensitive on market" (for specs see = http://www.ionspec.com/hiresmaldi.html); < $100,000 I also have these peptide and oligo synthesizers and sequencers for = sale: ABI 394 $12,500 (Valve blocks rebuilt; warranteed) ABI 390Z $4,000 (50-100uM yields) ABI 431 $12,500 (Rebuilt, warranteed) ABI 433 $19,000 (ABI upgrade) PerSeptive 9050+, $6,000 (As is/was working when decommissioned; = add $3,500 for rebuild/warranty) ABI 373 stretch $9,000 (Big dye upgrade; still under warranty) ABI 373 stretch $7,000 (4-filter) ABI 377 $97,500 (XL; 96 lanes; transferrable ABI = service contract) ABI Procise 492 $59,000 obo (ABI-certified) ABI Procise 494 $84,000 (ABI-certified) NMRs: Bruker AM360 $85,000 (Broadband; widebore; install included) Varian Gemini 300 $69,000 (Proton/carbon probe; freight, install, = 90-day warr. included) Bruker AMX-500 $175,000 (4 probes; inverse electronics; 90-day = warranty) Also available: HP 5989B LC/MS engine, extended mass range (2000 amu), hex ion = guide (HPLC, installation & warranty available): $45,000 Hitachi 570 scanning electron microscope, Kevex detector, running = now, $35,000. BD FACSVantage and assorted FACScans Various other seqencers, synthesizers etc. are available; please inquire = or check the website. Michael Sherrell Grizzly Analytical 707 887 2919/fax 707 887 9834 www.grizzlyanalytical.com=00 From owner-repertoires@net.bio.net Sat Apr 17 23:00:00 1999 Path: biosci!biosci!not-for-mail From: andy.zaayenga@bigfoot.com (Andy Zaayenga) Newsgroups: bionet.molecules.repertoires Subject: Announce: Laboratory Robotics CombiChem / HTS Meeting Date: 18 Apr 1999 04:29:46 -0700 Organization: Netcom Lines: 255 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <37552731.39298151@nntp.ix.netcom.com> NNTP-Posting-Host: net.bio.net The Laboratory Robotics Interest Group Mid Atlantic Chapter April 1999 Meeting Combinatorial Chemistry & High Throughput Screening Date:=20 Wednesday, April 21, 1999 Place:=20 Hanover Marriott,1401 Rt 10 E, Whippany, NJ 07981, Phone: 973-538-8811, F= ax: 973-538-0291 Itinerary:=20 Presentations and Discussion - 3:00 to 4:30 pm Social Period, Vendor Exhibits, Food, Refreshments & Poster Session - 4:= 30 to 6:30 pm Presentations and Discussion - 6:30 to 9:00 pm Pre-Registration: Requested, not required. Registering will allow us to more accurately gauge seating requirements and refreshment needs. Indica= te names of attendees and company affiliation. Email: andy.zaayenga@lab-robotics.org Phone: (732)302-1038 Fax: (732)302-9080 Agenda: The Social Period will feature vendor exhibits, food and refreshments. Members interested in presenting a poster are encouraged t= o do so. Open career positions at your company may be announced or posted. There is no fee to attend the meeting. Bring a business card to drop in = the registration fishbowl - it eases registration and qualifies you for the rosewood pen set drawing.=20 _______________________________________ Presentation: A New Reaction Block as the Core of an Integrated System f= or High Throughput Automated Organic Synthesis. Harold N. Weller, Walter Ruediger, Wen-Jeng Li, and John A. Allen Bristol-Myers Squibb Company, Pharmaceutical Research Institute, PO Box 4000, Princeton, New Jersey 08543 A new reaction block has been developed that forms the core of an integra= ted system for automated high throughput organic synthesis. Unlike many react= ors previously described, this new block is capable of either solid- or solution-phase parallel synthesis. In addition, it can also be used for t= he cleavage step from split and pool synthesis using commercially available MicroKan=99 reactors. The block offers large enough reaction scale to be = used for lead optimization, yet delivers products into standard 96-well format for efficient post synthesis processing. The reaction block is based on a novel multiple valve mechanism with a single functional moving part, lead= ing to low cost and high reliability. Maximum efficiency of this new reactor system is obtained from consolidat= ed post synthesis processing regardless of synthesis method. Post synthesis processing is based on product collection into custom microtubes in 96-we= ll format. Purpose built workstations process microtubes for weighing and selection for screening. This talk will describe the evolution and design of this new reactor syst= em, along with its place in an efficient overall automated synthesis operatio= n. _______________________________________ Presentation: ALPHAScreen a novel non-radioactive homogeneous assay technology for uHTS Changjin Wang, Ph.D., Director, ALPHAScreen Technology and Systems, Packa= rd Instrument Company This presentation will describe a novel assay technology termed Amplified Luminescent Proximity Homogeneous Assay, and its applications in drug discovery uHTS. The assay relies on two proprietary latex Donor and Accep= tor beads (~200 nm) and generates highly amplified long life fluorescent sign= al when the beads are brought into proximity upon a biological binding event. The Donor bead contains a photosensitizer which converts ambient oxygen t= o the excited singlet state upon excitation by a laser at 680 nm. The Accep= tor bead contains a thioxene derivative that reacts with the singlet oxygen rapidly and undergoes a quantitative first order decay with chemiluminescence at 370 nm, which is then transferred to the coexisting fluorephores through typical energy transfer process to generate fluorescence signal at 520-620 nm. Because of its short life time in aque= ous solution (~4 usec), singlet oxygen diffuses to a distance of no more than ~200 nm. We have developed 11 ALPHA assays including kinase, protease, helicase, protein-protein, protein-DNA, PCR, SNP detection, as well as cA= MP cell-based assay. I'll present data for representative assays in 384/1536 format using 1 to 20 ul volume. This technology enables quick miniaturization for uHTS without having to increase assay concentrations. _______________________________________ Presentation: A Solution-Phase High-Throughput Positional Scanning Appro= ach Hans-Joerg Roth 1) Positional scanning approach vs. full exploration of modular scaffolds 2) An example 3) Impact on Logistics and Infrastructure 4) Typical mistakes in parallel synthesis concepts 5) Conceptual conclusions _______________________________________ Presentation: COMPARATIVE STUDY ON THE FEASIBILITY OF THE ENZYME ASSAYS = AND CELLULAR REPORTER GENE ASSAYS IN YEAST IN THE 96-, 384- AND 1536-WELL PLA= TE FORMAT M. Berg, K. Undisz, R. Thiericke, S. Grabley, T. Moore* and C. Posten** Hans-Knoell-Institut f=FCr Naturstoff-Forschung e.V., Beutenbergstr. 11, D-07745 Jena, Germany, Tel.: ++49 3641 656926, Fax: ++49 3641 656944 * OPAL Jena GmbH, Goeschwitzerstr. 40, D-07745 Jena, Germany ** Institut f=FCr Mechanische Verfahrenstechnik und Mechanik der Universi= taet Karlsruhe (TH), Kaiserstr. 12, D-76185 Karsruhe, Germany Today=92s demands in the drug discovery process force pharmaceutical comp= anies to screen an ever increasing number of compounds against an increasing amount of targets. Consequently, miniaturization of established assays ha= s become an advantageous means in high-throughput-screening (HTS) to meet reagent and sample cost, turnaround and space requirements. One way to realize this is to move from the standard 96-well plate to higher density microplate formats. This talk will describe the adaptation of two fluorescence-based assay systems to the challenges of the 1536-well plate format from both the engineer=92s and biochemist=92s point of view. We optimized liquid handli= ng parameters of the micropipetting device JOBIwellTM (Jenoptik-Bioinstrumen= ts GmbH, Germany) using fluorescein-isothiocyanate as fluorescence dye. On t= his basis pipetting routines were established for an enzyme assay (=DF-galactosidase) and a transcription assay in yeast (human progesteron= e receptor, hPR) in the 384- and 1536-well format. Finally, the experimenta= l results were compared to those obtained in the well-established 96-well format. In all three assay formats, bioconversion of fluorescein-di-=DF-D-galactopyranoside occurred as a function of the =DF-galactosidase concentration (in vitro assay) and the reporter gene expression showed the expected dependence on the ligand=92s dose and affi= nity (yeast transcription assay), respectively. We conclude that miniaturizati= on using the higher density 384- and 1536-well plate formats is advantageous= as the next evolutionary step in HTS. JOBIwellTM proves to be a powerful too= l for a careful adaptation of the liquid handling procedures. _______________________________________ Presentation: Combinatorial synthesis using the IRORI Accutag system David M. Gange, Ph.D. During my talk I will discuss our experiences with the IRORI Accutag high-throughput synthesis system. I'll cover our use of the system, its' strengths, weaknesses, and how we plan to use the IRORI system in the future. _______________________________________ Presentation: Development of Fluorescence Polarization and FRET Assays f= or Tyrosine and Serine/Threonine Kinases Dr. Jinzi J. Wu, Senior Scientist III, Head of Assay Development and Optimization Lab, US Lead Finding Novartis Pharmaceuticals Corporation, Summit, NJ Homogeneous fluorescence approaches such as FRET and FP are very importan= t technologies for developing effective HTS assays for discovering therapeu= tic leads of kinases. This presentation will compare FRET and FP technologies for both tyrosine and serine/threonine kinase assays in terms of sensitivity, reliability and cost of reagents. The presentation will focu= s on discovery of a high affinity anti-phosphoserine antibody and applicati= ons of this antibody in the development of FP assays for a number of serine/threonine kinases. The preliminary screening data will also be discussed. _______________________________________ Exhibitors: Advanced ChemTech Amersham Pharmacia Biotech Argonaut B-D Falcon Beckman Coulter Bohdan Automation Cartesian Technologies, Inc. CCS Packard Corning, Inc CRS Gilson, Inc Hudson Control Group IGEN Labsystems LEAP Technologies LJL BioSystems Marsh Biomedical Products MDL Nalge Nunc International NEN Life Science Products PE-Biosystems QIAGEN, Inc./ROSYS, Inc. Robbins Scientific Corp. Skatron Instruments S-T Robotics Tecan US TekCel Titertek Tomtec _______________________________________ Directions (on line directions at http://marriotthotels.com/EWRHO/): Take Route 287 to Exit 39 (Route 10 West). Go through one stoplight and t= ake 1st u-turn.=20 _______________________________________ Andy Zaayenga Secretary, The Laboratory Robotics Interest Group LRIG Home & Mid Atlantic Chapter 1730 West Circle Drive Martinsville, NJ 08836-2147 Office: (732)302-1038 Fax: (732)302-9080 eFax: (630)604-2935 mailto:andy.zaayenga@lab-robotics.org web site: http://lab-robotics.org =20 From owner-repertoires@net.bio.net Sun Apr 18 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Steve Heller Newsgroups: bionet.molecules.repertoires Subject: ChemInt'99 - Abstract Submission Deadline extended Date: 19 Apr 1999 04:00:48 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 61 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net This note is to announce that final abstract submission date for poster talks at ChemInt'99 (www.chemint.org) has been extended to June 1, 1999. The web Abstract Submission form for ChemInt'99 is now operational for the Chemistry and the Internet (ChemInt'99) meeting. A number of abstracts have been submitted and those which have been accepted have been posted on the ChemInt'99 web site. ChemInt'99 is being held in at Georgetown University in Washington DC on September 25-27, 1999. The program of invited speakers and panel members of the 3 panel sessions is available on the meeting web site - www.chemint.org You are urged to look at the program and to consider submitting a poster paper to the meeting. A number of poster papers will be selected for oral presentation at the meeting. The main lecturers for the meeting will be: Alan Arnold, University College (UNSW) Steven Bachrach, Northern Illinois University Robert Bovenschulte, ACS Stephen Boyer, IBM Karl Harrison, Oxford University Clemens Jochum, Deutsche Bank Gary Mallard, NIST Tom Pierce, Rohm & Haas Jerome Reichman, Vanderbilt Achim Zielesny, Bayer AG Steven S. Zumdahl, University of Illinois at Urbana-Champaign The (current) corporate sponsors for the meeting are: ChemWeb and the Internet Journal of Chemistry Technical Sponsors are: ACS CINF Division ACS COMP Division The Chemical Structure Association (CSA) Georgetown University - Department of Chemistry International Union of Pure and Applied Chemistry (IUPAC) (pending) Japan Association for International Chemical Information (JAICI) Special Libraries Association (SLA) Chemistry Division Royal Society of Chemistry (RSC) Steve Heller Steve Heller, Guest Researcher NIST/SRD, Mail Stop: 820/113 820 Diamond Avenue, Room 101 Gaithersburg, MD 20899-2310 USA E-mail: chem@feldmann.nist.gov From owner-repertoires@net.bio.net Tue Apr 20 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Joan Boyce Newsgroups: bionet.molecules.repertoires Subject: 1999 Source Book available Free for Researchers Date: 21 Apr 1999 02:47:04 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 20 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <371CD2D8.7F0A@cshl.org> Reply-To: boyce@cshl.org NNTP-Posting-Host: net.bio.net Obtain a free copy of the 1999 Source Book (publication date May 10th), a comprehensive guide to bioresearch products, by filling in the request form at the BioSupplyNet site: http://www.biosupplynet.com. The Source Book provides up-to-date information about reagents, lab instrumentation, antibodies, custom services and supplies for high throughput analysis. The unique organization of the Source Book simplifies product searching and speeds the gathering of comparative information. The Source Book indexes products in 2650 categories, and provides up-to-date contact information, including WWW and e-mail addresses, for 3500 suppliers. Bench Basics comparative tables allow apples-to-apples comparisons of products. A special Lab Set-up Check List simplifies the process of putting together a new laboratory. Order your free copy at The BioSupplyNet web site at http://www.biosupplynet.com From owner-repertoires@net.bio.net Sun Apr 25 23:00:00 1999 Path: biosci!biosci!not-for-mail From: John Nelson Newsgroups: bionet.molecules.repertoires Subject: Cancer Research Studentship at QUB, Ireland Date: 26 Apr 1999 06:53:36 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 32 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Structure/function relationships in Epidermal Growth Factor Action Cancer Postgraduate Studentship A three year Action Cancer (NI) funded postgraduate studentship will be available from October 1999 in the Centre for Peptide and Protein Engineering within the School of Biology and Biochemistry, Queen's University Belfast. The project will extend ongoing studies within the Centre on structure/function relationships in Epidermal Growth Factor (EGF). This molecule and its cognate receptor are potential therapeutic targets in the control of tumour growth and metastasis. The successful applicant must have a first class or upper second class degree in Biochemistry or Molecular Biology or closely related subject. The student will firstly develop a random library of EGFs with mutations in specific regions of the molecule, this will be followed by selection for receptor binding species whose bioactivities will then be characterised. The stipend will be at MRC rates (currently 7070 pounds Sterling rising to 7910 p.a over three years) with full fees paid. For further details and application procedure please contact: Dr John Nelson, Centre for Peptide and Protein Engineering, School of Biology and Biochemistry, QUB, 97 Lisburn Road, Belfast BT9 7BL, Ireland. (e-mail: john.nelson@qub.ac.uk; Telephone: +44 1232 272107) Applications should be lodged by 15th May 1999. From owner-repertoires@net.bio.net Sun Apr 25 23:00:00 1999 Path: biosci!biosci!not-for-mail From: "Wang, Kevin" Newsgroups: bionet.molecules.repertoires Subject: Register for The Calpain System in Health and Disease, FASEB summer Date: 26 Apr 1999 06:28:21 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 43 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net The Calpain System in Health and Disease A FASEB summer Research conference June 20-25, 1999, Copper Mountain, Colorado, USA 28 invited international speakers For Application form, go to http://www.faseb.org/meetings/src/src99.html (Due May 20) 20 June (Sun) pm Keynote Address: Dr. Koichi Suzuki 21 June (Mon) am Calpain Structure/Calpain Isoforms S. Narayana; Z. Jia; H. Sorimachi pm Calpain Isoforms/Novel Calpains. Dear; A. A. Siddiqui; P. Friedrich; D. Mykles 22 June (Tue) am Calpastatin and Calpain Inhibitors. M. Maki; E. Melloni; P. Antin; K.K.W. Wang pm Regulation of Calpain Activity. D.E. Goll.; D. Croall; E. Carafoli 23 June (Wed) am Functions of the Calpain System I. J.E.B. Fox; R. Mellgren; G.V.W. Johnson; J. Elce pm Functions of the Calpain System II. P. Cottin, N. Banik, A. Belcastro 24 June (Thurs) am Calpains and Tissue Pathologies I. J. S. Beckman; M. Spencer., A. Stracher pm Calpains and Tissue Pathologies II. K. S. Lee; Selected Oral Presentations 25 June (Fri) am Calpains and Tissue Pathologies III. T. Shearer; S. Orrenius; R.L. Hayes ------------------------------------------------------------------------ The conference fees are $815 for single, $665 double, and $635 multiple occupancy. These fees include the scientific sessions, five nights in the hotel and 3 meals each day. http://www.faseb.org/meetings/src/99copper.html http://www.informatik.uni-rostock.de/HUM-MOLGEN/meetings/meetings/0813.html From owner-repertoires@net.bio.net Sun Apr 25 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Fran Martin Newsgroups: bionet.molecules.repertoires Subject: 225,000+ MSDS CD-ROM Date: 26 Apr 1999 02:35:45 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 17 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Professionals responsible for employee safety, Hazard Communications Plans, government-mandated MSDS libraries, and hazardous materials reporting may find this a useful reference: A database of over 225,000 Material Safety Data Sheets (MSDS) for trade name and generic chemicals has been updated on a three-CD-ROM set. The set features the Environmental Reporting Assist File (ERAF) and Registry of Lists (ROL) databases. See http://www.env-sol.com/solutions/MSDS.HTML for details. Fran Martin FM Research & Consulting From owner-repertoires@net.bio.net Mon Apr 26 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Guenter Grethe Newsgroups: bionet.molecules.repertoires Subject: 5th International Conference on Chemical Structures - Final Program Date: 27 Apr 1999 04:12:57 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 402 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <8E13FBBA26A9DA119ED400A0C9AB2CE501397657@shepherd.mdli.com> NNTP-Posting-Host: net.bio.net I APOLOGIZE FOR DUPLICATE POSTINGS. The Fifth International Conference on Chemical Structures is only a few weeks away (June 6 - 10). The Organizing Committee has put together an exciting program which is attached to this message. Those of you who participated in one of the earlier conferences know that this is one of the important venues for Chemical Information practitioners. In case you make a last-minute decision to participate please register as soon as possible as we are running out of rooms at the center. You can find information about registration on our web site at http://ChemWeb.com/conference/5iccs/5iccs.html. Guenter Grethe Conference Chair Dr. Guenter Grethe Director, Scientific Applications Product Development MDL Information Systems, Inc. 14600 Catalina Street, CA 94577 Tel.: (+1) 510-357-2222 ext.1430 Fax: (1) 510-614-3616 e-mail: guenter@mdli.com TECHNICAL PROGRAM FIFTH INTERNATIONAL CONFERENCE ON CHEMICAL STRUCTURES June 6 - June 10, 1999 Leeuwenhorst Congress Center Noordwijkerhout, The Netherlands SCHEDULE OF EVENTS FINAL PROGRAM Sunday, June 6 9:00-17:00 Registration 17:00 Opening Session Keynote Address: "The Internet and Electronic Publishing - A Disruptive Technology", Stephen Heller, NIST/SRD 18:00 Welcoming Reception, courtesy of MDL Information Systems 19:30 Rijsttafel Dinner, courtesy of Chemical Abstracts Service Monday, June 7 8:30 Opening Remarks: Guenter Grethe Session A - Combinatorial Chemistry: Library Design Peter Willett, Presiding 8:45 "Trends in Combinatorial Chemistry", Wendy A. Warr, Wendy Warr & Associates 9:15 "Sensitivity Analysis and Other Improved Tools for Combinatorial Library Design and Mixture Representation", Eric Martin, Chiron Corporation 9:45 "Structure Based Design of Combinatorial Libraries", Robert D. Brown, Molecular Simulations Inc. 10:15 Break 10:45 "Enhancing Hit-To-Lead Properties of Diverse Libraries", Stephen D. Pickett, Rhone-Poulenc Rorer 11:15 "De Novo Design of Synthetically Accessible Ligands", A. Peter Johnson, University of Leeds 11:45 "Optimisation of 3D Focussed Libraries with PLUMS", Gianpaolo Bravi, GlaxoWellcome UK 12:15 "The Design of Maximum Information Libraries as a Highly Efficient Tool for Lead Generation and Evolution", Peter Grootenhuis, CombiChem 13:00 Lunch 14:00-22:00 Exhibits Open - Atrium Poster Session Open (see listing below) - Atrium (authors will be present from 14:00 - 18:00) John Blackmore and Jacques Weber, Presiding 18:30 Reception and Buffet Dinner - Atrium Tuesday, June 8 Session B - Combinatorial Chemistry: Diversity, QSAR Gerald Maggiora, Presiding 9:00 "Computer Manipulation of Large Virtual Combinatorial Libraries for Diversity Analysis and Subset Selection", John M. Barnard, BCI Ltd. 9:30 "Potential Drugs and Non-Drugs: Prediction and Identification of Important Structural Features", Markus Wagener, NV Organon 10:00 "Advances in the Design and Visualization of Combinatorial Libraries", Dimitris K. Agrafiotis, 3-Dimensional Pharmaceuticals, Inc. 10:30 Break 11:00 "High Throughput and Combinatorial qSAR", Trevor Heritage, Tripos Inc. 11:30 "Reduced Graphs as Descriptors of Bioactivity", Valerie J. Gillet, University of Sheffield 12:00 "Quantum Mechanical Modeling in the Cheminformatics Age", Nick Jones, Oxford Molecular Group 12:30 "Datamining the CAS databases for Biological Activity", William Fisanick, Chemical Abstracts Service 13:00 Lunch 14:00-22:00 Exhibits Open Poster Session Open (see listing below) New Product Review Session Rainer Moll, Presiding 14:30 "Chemistry First - Accord Solutions for the Enumeration Problem", Julian Hayward, Synopsys Scientific Systems Ltd. 14:55 "RS3 for Excel", Sheila Ash, Oxford Molecular Limited 15:20 "3D Molecular Design and Visualization Toolkit", Zsolt Zsoldos, SimBioSys Inc. 15:45 Break 16:10 "Java Applets and Modules Supporting Chemical Database Handling from Web Browsers", Ferenc Csizmadia, ChemAxon Ltd. 16:35 "LINK - Springer Verlag", Getraud Griepke, Springer-Verlag 17:00 "ACD/LAB: Web-Based Chemical Property Prediction Center", Val Kulkov, Advanced Chemistry Development, Inc. 17:25 "An Integrated Software System for Processing, Prediction, Spectral Management and Automated Structure Elucidation", Antony J. Williams, Advanced Chemistry Development Inc. 18:15 Open Meeting of the CSA 19:30 Dinner Wednesday, June 9 Session C - Web Applications, ChemInformatics, Reactions Johann Gasteiger, Presiding 8:30 "Dataflow Programming in a WWW Environment", Wolf D. Ihlenfeldt, University of Erlangen-Nurnberg 9:00 "Experiences with Web-Based Tools in Teaching Chemical Information", Engelbert Zass, ETH Zurich 9:30 "The ChemWeb Chemistry Whiteboard - An Aid to Communication of Chemical Information in a Virtual Community", Brian Vickery, ChemWeb Inc. 10:00 "Cross Domain Integration in the Life Sciences - The Role of CORBA and the Object Management Group", Andrew Payne, NetGenics UK Ltd. 10:30 Break 11:00 "Adding Chemical Objects and Operators to SQL: Experiences with Oracle(TM) 8i Data Cartridge Technology", Raymond E. Carhart, MDL Information Systems, Inc. 11:30 "The Chemical Workbench - A Reaction-Centered Synthesis Design Tool", Hartmut Braun, Hoffmann La Roche 12:00 "Topology-Based Reaction Classification: An Important Tool for Efficient Management of Reaction Information", Heinz Matuszczyk, InfoChem GmbH 12:30 "The Predicting of Organic Reaction Products: Determining the Best Reaction Conditions", Marco Durante, Universita' degli Studi di Milano 13:00 Box Luncheon 13:30 Excursion and Conference Dinner Busses leave from the Conference Centre Thursday, June 10 Session D - Modeling, Similarity, QSAR Vincent van Geerestein, Presiding 8:30 "Addressing Conformational Flexibility", Christof H. Schwab, University of Erlangen-Nurnberg 9:00 "A Novel Treatment of Conformational Flexibility Using Interval Analysis, Miklos Vargyas, University of Leeds 9:30 "A New Approach to Molecular Docking and Its Application in Screening Compound Databases, Carol A. Baxter, Proteus Molecular Design Ltd. 10:00 "Field-Based Similarity Forcing: A Conformationally-Flexible Approach to Molecular Matching", Gerald M. Maggiora, Pharmacia & Upjohn 10:30 Break 11:00 "Reference Panel Optimization for Flexsim-X: A Method to Detect Molecules With Similar Biological Activity", Uta Lessel, Boehringer Ingelheim Pharma KG 11:30 "Example of Successful Prediction of Biological Activities", Eugene V. Babaev, Moscow State University 12:00 Panel Discussion - Conference Summary 12:30 Closing Remarks: Guenter Grethe 13:00 Lunch Posters "REACTION", Edward S. Blurock, RISC-LINZ, Johannes Kepler University, Linz "How to Discover Experimentally Novel Recyclization Reactions Using the Program GREH", Eugene V. Babaev, Moscow State University "Pseudo-Hypergraphs and Hypertopoids: Novel Topological Objects Suitable to Describe the Molecules with Multi-Centered Bonds", Eugene V. Babaev, Moscow State University "Multilevel Neighborhoods of Atoms as the Sub-Structural Topological Descriptors for Predicting the Bioactivities and Properties of Compounds", Dmitrii Filimonov, Institute of Biomedical Chemistry RAMS, Moscow; presented by Eugene V. Babaev, Moscow State University (tentative) "Predicting the Structure of the Drug-Receptor Complex: A Quantum Chemistry and Thermodynamic Model", Gerardo Gonzales, University of Camguey, Cuba "A Theoretical Study about the Transition State of the Nitration of Flavonoids and its Relationship to its Carcinogenic Power, Elismary Rodriguez, University of Camguey, Cuba "Modelling Synthetic Organic Peroxides in the Search of Potent Antimalarial Agents. Refinement Studies of the Hypothetical Pharmacophore", Jaques Weber, University of Geneva "Graph-Theoretical Techniques for Macromolecular Docking", Eleanor J. Gardiner, University of Sheffield "The Use and Development of the Molecular Vibrational Descriptor EVA for QSAR Studies and Similarity Calculations", David Turner, University of Sheffield "Identification of Bioisosteres Using Field-Based Similarity Searching", Ansgar Schuffenhauer, University of Sheffield "Three-Dimensional Similarity of Functional Groups", Paul Watson, University of Sheffield "A Genetic Algorithm for Clustering Datasets via their Modes of Action", David Wilton, University of Sheffield "Classification of Molecular Bioassay Data", David B. Turner, University of Sheffield "Alignment of Molecular Fields for 3D-QSAR Using FBSS", Nicholas Jewell, University of Sheffield "Evaluation of Three-Dimensional Structural Similarities of Angiotensin Antagonists by Means of a Hybrid Method, Sandra Handschuh, University of Erlangen-Nurnberg "Expert System Assisted Pharmacophore Identification", Attilla K.T. King, University of Leeds "Using Pharmacophore Similarity as a Basis for Compound Selection", Richard D. R. Postance, Oxford Molecular Group "Modelling of Supramolecular Structure and Mechanisms of Thermo- and Photochemical Decomposition of 3d-Metals Hypophosphites", L.A. Pavlyukhina, Institute of Solid State Chemistry and Mechanochemistry SBRAS, Novosibirsk "A Large Database of Organic Substituents with Calculated Properties (and what can be done with it)", Peter Ertl, Novartis Crop Protection AG "A Universal Model for all Organic Solvent/Water Partition Coefficients. Local LogP Maps Near Selected Atoms", Francisco Torrens, University of Valencia "Molecular Modelling of Calix[n]arene Inclusion Complexes: A Basic Study", Darren Fayne, Dublin City University "Conformational Analysis of Complexes of Phosphine Oxide Calix[4]arenes with Group 1 and 2 Cations", Paddy Kane, Dublin City University "Fuzzy Definition of Molecular Fragment in Chemical Structures", Barbara Debska, Rzeszow University of Technology "Structure Elucidation by Expert System Generated from Infrared Spectral Database", Barbara Debska, Rzeszow University of Technology "Automated Structure Elucidation from1D C-13 Spectral Data", Antony Williams, Advanced Chemistry Development, Inc. "NMR Prediction Software and Tubeless NMR - An Analytical Tool for Screening of Combinatorial Libraries", Antony Williams, Advanced Chemistry Development, Inc. "Maximum Common Substructures of Organic Compounds Exhibiting Similar Infrared Spectra or Mass Spectra", Kurt Varmuza, Vienna University of Technology "Substructure Isomorphism Matrix: Software and Applications", Kurt Varmuza, Vienna University of Technology "Name=3DStruc: Automated Generation of Structural Diagrams from Chemical Names", Jonathan Brecher, CambridgeSoft Corporation "A Comparison of 2D Fingerprint Types and Hierarchy Level Selection Methods for Structural Grouping Using Ward's Clustering", David J. Wild, Parke-Davis Pharmaceutical Research "Computer Search for High Energetic Organic Compounds from the Automatically Generated Chemical Structure Database", M. Karthikeyan, ARDE, India "Internal Rotation Studies on Some Aromatic Nitrocompounds", Pei-Chung Chen, Institute of Technology, Taiwan "Cheshire: A New Scripting Language for Chemical Structure Manipulation", Joseph L. Durant, MDL Information Systems, Inc. "MIRACLE - Managing the Inventory of Available Chemicals in Laboratories", Heinz A. Krebs, Technische Universitaet Wien "The Development of a Web Based System for the Online Shopping of Compounds", Ferenc Csizmadia, ChemAxon "A New Format for the Efficient Storage of Molecular Structures", Peter Csizmadia, ChemAxon "A Novel Graph Descriptor for Cyclic Molecules : The Smallest Set of Rings which Contains All Bonds (SSRCAB). Application as Screening Criterion for Structure Search in Large Databases of Organic Compounds, Laurent Dury, University Notre-Dame de la Paix, Namur "Rule-Based System for Chemistry", Kyi Kyi Tin, Assumption University of Thailand "Organizational and Technical Aspects of Academic Database Cooperation", Engelbert Zass, ETH Zurich "Fingerprint-Based Methods for Selective Compound Acquisition", Nick Rhodes, University of Sheffield "Binning Schemes for Partition-Based Compound Selection", Martin J. Bayley, University of Sheffield "Accessing the Three-Dimensional World of Molecules", Christof H. Schwab, Molecular Networks GmbH Computerchemie "VLSPROUT - A Structure-Based Virtual Library Screening System", Jean-Francois Marchaland, University of Leeds "Diversity Measures for Enhancing ADME Admissibility of Combinatorial Libraries. The Mediverse Approach", Ferenc Darvas, ComGenex Inc. "Analyzing HTS Data - An Approach Using Neural Networks", Andreas Teckentrup, University of Erlangen-Nurnberg. "Preliminary Handling of Virtual Library", Andrey Efimov, ChemBridge Ltd. "LiBrain, An Intelligent System for the High Thoughput Design of Combinatorial Libraries in Drug Discovery", Shenghua Shi, Alanex Corporation "WebLab MedChem Explorer and Diversity Explorer", Robert Brown, Molecular Simulations, Inc. "ClariNet: A Tool for the Exploitation of Experimental Structural Databases", Veronique Guerin, Rhone-Poulenc-Rorer CRVA "Searching Chemical Structure and Reaction Data via the Internet", Michael Wittmann, InfoChem GmbH "Use of Intranet and Internet Technologies for Publishing Chemical Structure and Reaction Information", Robert A. Scoffin, CambridgeSoft Corporation From owner-repertoires@net.bio.net Mon Apr 26 23:00:00 1999 Path: biosci!biosci!not-for-mail From: frank.logullo@dol.net Newsgroups: bionet.molecules.repertoires Subject: Re: 225,000+ MSDS CD-ROM Date: 27 Apr 1999 02:36:55 -0700 Organization: Deja News - The Leader in Internet Discussion Lines: 29 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <7g2b8b$rr5$1@nnrp1.dejanews.com> References: NNTP-Posting-Host: net.bio.net In article , Fran Martin wrote: > Professionals responsible for employee safety, Hazard Communications Plans, > government-mandated MSDS libraries, and hazardous materials reporting may > find this a useful reference: > > A database of over 225,000 Material Safety Data Sheets (MSDS) for trade name > and generic chemicals has been updated on a three-CD-ROM set. The set > features the Environmental Reporting Assist File (ERAF) and Registry of > Lists (ROL) databases. > > See http://www.env-sol.com/solutions/MSDS.HTML for details. > > Fran Martin > FM Research & Consulting Thanks for posting this. I write MSDS's and am always in need of sources and had considered this one. Unfortunately what it does in quantity is lacking in quality. Does not follow recommended ANSI format and the acetone MSDS listed did not even contain DOT UN number. Frank > > -----------== Posted via Deja News, The Discussion Network ==---------- http://www.dejanews.com/ Search, Read, Discuss, or Start Your Own From owner-repertoires@net.bio.net Tue Apr 27 23:00:00 1999 Path: biosci!biosci!not-for-mail From: JONATHAN GERSON Newsgroups: bionet.molecules.repertoires Subject: Combinatorial Chemistry Information Date: 28 Apr 1999 05:12:10 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 43 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <17K937YL.7O04YE6W@ibcusa.com> NNTP-Posting-Host: net.bio.net *Ultra High Throughput Screening *Case studies on how to implement a combinatorial chemistry program *Design smarter libraries All these topics and more at IBC's 4th Annual Combinatorial Chemistry Conference - From Concept to Clinic. June 28-29, 1999, La Jolla, CA. Space is filling up, reserve your place today. http://www.ibcusa.com/2353/default.asp?DEAL=EM1 **** Drug and Market Development Newsletter - Bridging the gap between R&D and marketing in the pharmaceutical and biotechnology market. Free feature article - this month's - Proteomics in Europe. http://www.ibcusa.com/dmd/newsletter **** Hear from the leaders - Leroy Hood, M.D., Ph.D., University of Washington, Michael Pavia, Ph.D., Millennium Pharmaceuticals, Inc., George Poste, Ph.D., SmithKline Beecham Pharmaceuticals, Stuart L. Schreiber, Ph.D., Harvard University. Only at IBC's Drug Discovery Technology 1999 - The World's Drug Discovery Meeting Place http://www.drugdisc.com **** For further information, visit http://www.ibcusa.com Or contact Jonathan Gerson, jgerson@ibcusa.com IBC USA Conferences 225 Turnpike Road Southborough, MA 01772 508-481-6400 From owner-repertoires@net.bio.net Tue Apr 27 23:00:00 1999 Path: biosci!biosci!not-for-mail From: Ben Dunn Newsgroups: bionet.molecules.repertoires Subject: International Conference on Protease Inhibitors Date: 28 Apr 1999 09:39:57 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 25 Sender: daemon@net.bio.net Approved: A.Wallace@Queens-Belfast.AC.UK Distribution: world Message-ID: <199904272103.WAA17393@listserv.rl.ac.uk> NNTP-Posting-Host: net.bio.net Dear Protease Researchers: We have established a web site for the 2nd International Conference on Protease Inhibitors. The URL for this is: http://www.ufbi.ufl.edu/conferences/icpi Please examine this site and consider attending this conference. There will be chanages to the web site as time goes by. We already have additional invited speakers to post, for example. As indicated, we are calling for contributions and would like to receive information about exciting new developments that should be presented at the meeting. I look forward to hearing from you. Best wishes, Ben Dunn Ben M. Dunn, Distinguished Professor Biochemistry & Molecular Biology University of Florida College of Medicine