From owner-repertoires@net.bio.net Thu Jul 01 07:49:00 1999
Path: biosci!biosci!not-for-mail
From: BIOSCI Administrator <biohelp@net.bio.net>
Newsgroups: bionet.molecules.repertoires
Subject: BIOSCI/bionet miniFAQ & Fundraiser
Date: 1 Jul 1999 01:49:13 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 236
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(LAST REVISION: 30-JUL-95)

This BIOSCI "miniFAQ" is designed to answer the questions that come up
the *most frequently*.  The main BIOSCI FAQ (Frequently Asked
Questions) is accessible on the World Wide Web at URL
http://www.bio.net/.

If you can not find an answer to your question in this or other
documentation, the BIOSCI technical support staff answers e-mail
queries sent to

		       biosci-help@net.bio.net

We can only answer questions about the use of the newsgroups and
mailing lists.  We unfortunately do not have the staff to do Internet
information searches or answer scientific questions.  Please post
those to the appropriate BIOSCI/bionet newsgroups.


	Contents:
	--------
	0) BIOSCI NEEDS YOUR SUPPORT!!

	1) Using the WWW to access the BIOSCI/bionet newsgroups.

	2) What to do about "spams," i.e., junk mail, ads, etc.

	3) Examples of subscribing and unsubscribing to the mailing lists.

	4) The BIOSCI user address and research interest directory.


0) BIOSCI NEEDS YOUR SUPPORT!!
------------------------------
BIOSCI's government funding has been expended, and we are now
operating solely from advertising revenue that we have raised from our
Web site at http://www.bio.net/.  We need just a few minutes of your
time to help us serve you.

You can do two important things which will take very little time for
you individually and will immensely help us continue to help you.

First, please use our WWW system at http://www.bio.net/ to access the
archives.  You can post or reply to messages via your Web browser as
described in item #1 below.  Your usage helps attract sponsors. If you
contact any of our sponsors, please be sure to thank them for
supporting BIOSCI. It is critical for them to get this feedback if
they are to continue their sponsorship for the long term.

Second, if you work for a company or organization that provides
products or services of interest to the biology community, please pass
this message on to your marketing or marketing communications
department or other appropriate group.  Please ask them to help
support BIOSCI by sponsoring our Web site and explain the uses and
benefits of the system to the biology community. If they are
interested, they can then contact us for further information at our
tech support address, biosci-help@net.bio.net.


1) Using the WWW to access the BIOSCI/bionet newsgroups.
--------------------------------------------------------
As of 10 December 1995, all BIOSCI/bionet full newsgroups are
accessible through the World Wide Web (WWW) at URL http://www.bio.net.
One can read and reply publicly or privately to both recent postings
and archived messages through one's Web browser if it is configured
properly to send e-mail.  Each newsgroup is equipped with its own WAIS
index.  The main BIOSCI home page also has access to the BIO-JOURNALS
Table of Contents database WAIS index and the BIOSCI user address
database described in another item further below.


2) What to do about "spams," i.e., junk mail, ads, etc.
-------------------------------------------------------
BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups),
mailing lists, and a hypermail archive at URL http://www.bio.net/.
The same postings are distributed on all media (except for a small
number of mailing-list-only groups at net.bio.net).  Unfortunately it
is becoming a despicable practice on the Internet (by a few people out
to make a fast buck) to do automated mass postings to thousands of
newsgroups and mailing lists.  These attempts to grab free advertising
are refered to as "spams" in the usual, somewhat boneheaded, net
terminology.  USENET is more susceptible to this practice, and many
spams originate on the USENET groups and then are passed on to the
mailing lists.  However, spammers also get lists of mailing addresses
and hit these too, so neither medium is immune.

What should you do personally if you get junk mail?
---------------------------------------------------
Just delete it and move on without reading it further.  Filing a
protest is becoming increasingly useless because spammers are often
disguising the addresses where the messages are sent from.  Unless you
really understand Internet mail systems, your attempt at protest by
sending replies to the message will often end up being sent to the
address of an innocent person that the spammer is victimizing.

What can BIOSCI/bionet do to protect its newsgroups?
----------------------------------------------------
The only solution currently available is to moderate the newsgroup.
If this newsgroup is already moderated, then you are in good shape.
Moderation protects the USENET distribution from about 95% of the
spams that are being sent to date and protects the mailing lists
completely.  Moderation means, however, that someone has to take the
time to review each message before it goes out.  We have set up
software here that simply allows the moderator to forward to an
address at net.bio.net messages that (s)he wishes to have distributed.
This takes no more time than that needed to read the message and pass
it on, say about 1 min. per message.

Most newsgroups currently have a discussion leader who is responsible
for their newsgroup.  The discussions leaders and their e-mail
addresses are listed in the BIOSCI Information Sheet which is
available on the Web at http://www.bio.net/.  If a newsgroup is being
hit with too many junk postings, please contact the discussion leader
for that group and see if there is interest in moderating the group.
Please do not assume that by simply posting a complaint to the
newsgroup itself, anyone on the BIOSCI staff will act on your
complaint.  With close to 100 newsgroups to run, the BIOSCI staff has
to rely on the discussion leaders of each newsgroup to report problems
directly to us at biosci-help@net.bio.net.

We will moderate any of our newsgroups if the discussion leader tells
us that the readership of the group wishes to do so and if a moderator
is willing to do the work.  For most BIOSCI/bionet groups, this
entails only a few minutes of work each day.

Moderating a newsgroup will resolve probably 95% of the junk postings
on the USENET distribution.  Unfortunately there are easy ways for
determined spammers to override the moderation mechanism on USENET,
but we can protect our e-mail subscribers from unwanted postings if
the newsgroup is moderated.  You can also access our newsgroups over
the WWW at URL http://www.bio.net.  While this Web interface will not
stop spammers from trying to post to the groups, this will give you
yet another way, besides using USENET news, to keep the junk out of
your personal mail files.  For those of you with local USENET news
systems, the Web interface will also give you faster access to new
newsgroups and recent postings.


3) Examples of subscribing and unsubscribing to the mailing lists.
------------------------------------------------------------------
PLEASE NOTE: The BIOSCI management does NOT act on
subscription/unsubscription requests that are posted improperly to the
newsgroups and mailing lists.  People who do this only bother everyone
on the lists to no avail.  Please be sure to follow the proper
procedures below.

Gory details are in the BIOSCI Information sheets on the Web at
http://www.bio.net.  Below we give an example utilizing the
METHODS-AND-REAGENTS list at both of our two BIOSCI sites:

Users in the Americas and Pacific Rim countries who use the BIOSCI
------------------------------------------------------------------
node at computer net.bio.net:
----------------------------

A) Determine the "listname" which is the <=8 character mail address
                                         ^^^^^^^^^^^^^
   for the group.  These can be found in the BIOSCI Info. Sheet.  For
   the METHODS-AND-REAGENTS group the mailing address is
   methods@net.bio.net.  The listname is the portion of the address to
   the left of the @ sign, i.e., "methods".  The listname is used with
   the "subscribe" and "unsubscribe" commands illustrated below.

B) Mail all commands in the body of a mail message addressed to
   biosci-server@net.bio.net.  Do NOT send commands to the newsgroup
   posting addresses!  Leave the Subject: line blank, any text on it
   will be ignored.

C) In the body of your message put one or more of the following
   commands with an "end" command on the last line, e.g.,

   subscribe methods
   unsubscribe methods
   end

   Do NOT put your e-mail address or other text on these lines.  The
   server only allows you to cancel your subscription if the address
   on your mail header matches the address on our mailing list.
   Please ask for help at biosci-help@net.bio.net if your address has
   changed, e.g., if you know you are on the list but the server tells
   you that you are not a member.


Users in Europe, Africa, and Central Asia who use the BIOSCI node at
--------------------------------------------------------------------
computer daresbury.ac.uk (also known as dl.ac.uk):
-------------------------------------------------

To subscribe and unsubscribe to/from the BIOSCI lists, you need to
specify the full USENET newsgroup name with "bionet-news." prepended.
The USENET newsgroup names are listed in the BIOSCI Information sheet
on the Web at http://www.bio.net/.  For the METHODS-AND-REAGENTS list
the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the
appropriate commands are

    sub bionet-news.bionet.molbio.methds-reagnts

    unsub bionet-news.bionet.molbio.methds-reagnts

These commands are included in a message addressed to mxt@dl.ac.uk,
NOT to the newsgroup mailing addresses.  As usual, include the text in
the body of the message as text on the Subject: line is ignored.

To unsubscribe from all the lists at the UK node, use

    unsub bionet-news

Please note that if the address in the list is different than the one
in your mail message header, you will not be able to unsubscribe by
this method. If you have problems, please mail biosci@daresbury.ac.uk.


4) The BIOSCI user address and research interest directory.
-----------------------------------------------------------
Please take this opportunity to add your name, address, and research
interest information to the BIOSCI User Address Database if you have
not already done so.

You can fill out the address form directly through our Web page at URL
http://www.bio.net/adrform.html.

The address database is reindexed nightly for WWW access (the URL is
http://www.bio.net/).  If you are not directly on the Internet but can
reach it by e-mail, please use our waismail server to access the user
directory.  waismail use is described above.  You can also request a
user address form by e-mail from biosci-help@net.bio.net.

Please check your database entry from time-to-time to see if your
address information is still up-to-date.  Because of our limited
personnel resources, we ask that you resubmit a *complete* form to
revise your entry; we only replace complete entries and do not have
resources to edit old forms.





From owner-repertoires@net.bio.net Thu Jul 08 09:02:00 1999
Path: biosci!biosci!not-for-mail
From: Lynn Caporale <caporale@usa.net>
Newsgroups: bionet.molecules.repertoires
Subject: Molecular Stategies in biological evolution
Date: 8 Jul 1999 03:02:08 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 11
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NNTP-Posting-Host: net.bio.net

 I would like to draw your attention to the publication of "Molecular
Strategies in Biological Evolution", a very interesting and provocative
group of papers from a conference on that subject.  For your information,
the table of contents can be found at:
http://www.nyas.org/biological.html
Lynn Caporale






From owner-repertoires@net.bio.net Thu Jul 08 13:41:00 1999
Path: biosci!biosci!not-for-mail
From: Tara Dyson <tara@CURSCI.CO.UK>
Newsgroups: bionet.molecules.repertoires
Subject: Current Opinion in Cardiovascular, Pulmonary and Renal
Date: 8 Jul 1999 07:41:00 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 60
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Message-ID: <D30803A7DBFED011A78400A024F23BE701DB987A@exchange.cursci.co.uk>
NNTP-Posting-Host: net.bio.net

ANNOUNCING  - CURRENT OPINION IN CARDIOVASCULAR, PULMONARY & RENAL
INVESTIGATIONAL DRUGS -  A NEW REVIEW JOURNAL

FREE SAMPLE COPIES AVAILABLE

Current Opinion in Cardiovascular, Pulmonary & Renal Investigational Drugs
is a new bimonthly review journal published by Current Drugs Ltd, which
covers all aspects of cardiovascular, pulmonary and renal investigational
drug research.

The journal provides a comprehensive and up-to-date source of peer-reviewed
information on trends and advances in therapies for cardiovascular,
pulmonary and renal diseases. In addition, expert commentaries on the
scientific and commercial potential of selected drugs in clinical trials are
provided in each issue.

Edited by William C Ripka and Annette M Doherty, the journal is designed to
combat the proliferation of the scientific literature by giving the reader
an intelligent overview of the important developments across the entire
subject. The journal contents are divided into six major sections, each of
which is reviewed once a year.

        Antithrombotics and hematological disorders
                Atherosclerosis/hypercholesterolemia and heart disease
        Hypertension and renal failure
        Airway diseases including asthma, allergy and pulmonary hypertension
        Ischemia and infarction, including stroke and angina
        Arrhythmia and heart failure

Contributions from internationally recognized researchers are all invited
and peer-reviewed by an Editorial Board of distinguished members of the
scientific community. The views of experts in the form of editorial
overviews, review articles, drug evaluations, and annotated paper and patent
coverage are contained in each issue.

For further information, see the Current Drugs website
http://www.current-drugs.com

To request your FREE SAMPLE COPY mailto:cocvrsamp@cursci.co.uk
and supply us with your name, company, address, telephone number and email
details.

Kind regards

Tara Dyson
Editorial Director
Current Drugs Ltd
Middlesex House
34-42 Cleveland Street
London
W1P 6LB
UK
Tel: +44-171-580-8393
Fax: +44-171-580-5646
Email: tara@cursci.co.uk
http://www.current-drugs.com





From owner-repertoires@net.bio.net Fri Jul 09 11:14:00 1999
Path: biosci!biosci!not-for-mail
From: Steve Heller <chem@FELDMANN.NIST.GOV>
Newsgroups: bionet.molecules.repertoires
Subject: ChemInt'99 - Complete program now available
Date: 9 Jul 1999 05:14:31 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 67
Sender: daemon@net.bio.net
Approved: A.Wallace@Queens-Belfast.AC.UK
Distribution: world
Message-ID: <Pine.SOL.3.96.990706090640.4427C-100000@feldmann.nist.gov>
NNTP-Posting-Host: net.bio.net

The complete program of all lectures and contributed talks for the
Chemistry & the Internet meeting is now available.  The web site is
also now keyword searchable. All of the ChemInt'98 presentations on the
web site can be searched.  Go to: www.chemint.org

This note is to also a reminder that the deadline for poster abstracts
submissions for presentations at the ChemInt'99 meeting is September 1.

The Chemistry and the Internet (ChemInt'99) meeting being held in at
Georgetown University in Washington DC on September 25-27, 1999.

The program of invited speakers and panel members of the 3 panel sessions
is available on the meeting web site - www.chemint.org

You are urged to look at the program and to consider submitting a
poster paper to the meeting.

The main lecturers for the meeting will be:

Alan Arnold, University College (UNSW)
Steven Bachrach, Northern Illinois University
Robert Bovenschulte, ACS
Stephen Boyer, IBM
Karl Harrison, Oxford University
Clemens Jochum, Deutsche Bank
Gary Mallard, NIST
Tom Pierce, Rohm & Haas
Jerome Reichman, Vanderbilt
Achim Zielesny, Bayer AG
Steven S. Zumdahl, University of Illinois at Urbana-Champaign



The (current) corporate sponsors for the meeting are:

ChemWeb and the Internet Journal of Chemistry (IJC)


Technical Sponsors are:

ACS CINF Division
ACS COMP Division
The Chemical Structure Association (CSA)
Georgetown University - Department of Chemistry
International Union of Pure and Applied Chemistry (IUPAC) (pending)
Japan Association for International Chemical Information (JAICI)
Special Libraries Association (SLA) Chemistry Division
Royal Society of Chemistry (RSC)



Steve Heller



Steve Heller, Guest Researcher
NIST/SRD, Mail Stop: 820/113
820 Diamond Avenue, Room 101
Gaithersburg, MD 20899-2310 USA
E-mail:  srheller@nist.gov








From owner-repertoires@net.bio.net Tue Jul 13 11:44:00 1999
Path: biosci!biosci!not-for-mail
From: Jens Lohrmann <lohrmann@sun2.ruf.uni-freiburg.de>
Newsgroups: bionet.molecules.repertoires
Subject: Phosphoramidate
Date: 13 Jul 1999 05:44:09 -0700
Organization: Rechenzentrum der Universitaet Freiburg, Germany
Lines: 29
Sender: daemon@net.bio.net
Approved: a.wallace@qub.ac.uk
Distribution: world
Message-ID: <378B00B4.D7DEFD42@sun2.ruf.uni-freiburg.de>
NNTP-Posting-Host: net.bio.net

Dear Netters!

I'm looking for some information about phosphoramidate. I'm working in a

molecular plant physiology lab and would like to run an experiment using

p32-labelled phosphoramidate. Unfortunately I'm not aware of a
commercial supplier selling the labelled reagent or an unlabelled
precursor.

So please kindly inform me if you know about a company selling either
the p32-labelled phosphoramidate or the precursor.

The second question would be the following: does someone know a lab or
work in a lab which is synthesising phosphoramidate or the precursor in
a non-commercial scale and is willing to share an aliquot?

I greatly appreciate your help and really look desperately forward to
your answer!

Jens Lohrmann
Albert-Ludwigs-University
Freiburg, Germany

lohrmann@sun2.ruf.uni-freiburg.de





From owner-repertoires@net.bio.net Tue Jul 13 11:47:00 1999
Path: biosci!biosci!not-for-mail
From: Steve Heller <chem@FELDMANN.NIST.GOV>
Newsgroups: bionet.molecules.repertoires
Subject: Internet Journal of Chemistry (IJC) move
Date: 13 Jul 1999 05:47:19 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 20
Sender: daemon@net.bio.net
Approved: a.wallace@qub.ac.uk
Distribution: world
Message-ID: <Pine.SOL.3.96.990708112051.7161A-100000@feldmann.nist.gov>
NNTP-Posting-Host: net.bio.net

*********************
Due to a relocation of the server, the Internet Journal of Chemistry
(http://www.ijc.com/) will be unavailable from July 26 to early in
August. The URL will remain the same after the move. As soon as the
server is available again, an announcement of the reappaerance of the
journal will be sent off to many email lists.

We apologize in advance for any inconvenience this temporary interuption

of services may have.

Sincerely,

Steven Bachrach
Editor-in-Chief, Internet Journal of Chemistry
**********************





From owner-repertoires@net.bio.net Tue Jul 13 11:51:00 1999
Path: biosci!biosci!not-for-mail
From: Shu-Kun Lin <lin@mdpi.org>
Newsgroups: bionet.molecules.repertoires
Subject: Annual Review of Chemical Resources on the Internet
Date: 13 Jul 1999 05:51:08 -0700
Organization: MDPI (http://www.mdpi.org)
Lines: 71
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Approved: a.wallace@qub.ac.uk
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NNTP-Posting-Host: net.bio.net

I would like to invite you to contribute short papers
for presentation at ECSOC-3
(http://www.mdpi.org/ecsoc-3.htm section E) and
for publication in a special issue (December 1999)
"Annual Review of Chemical Resources on the Internet" of
MOLECULES (http://www.mdpi.org/molecules/). Any suggestions
are welcomed.

Titles and Topics are

Links for Chemists
  Main website: http://www.liv.ac.uk/Chemistry/Links/links.html
  Author(s): Michael H. Barker <M.H.Barker@liverpool.ac.uk>
Online-only Journals Monitored by Chemical Abstracts
  Main website: http://www.cas.org/EO/ejourn2.html
  Author(s): Nancy Simons <simons.28@osu.edu>
Web-Based 2D Structure Registration and Search
  Main website: http://www.mdpi.org/forum.htm#chemicals
  Author(s): (Shu-Kun Lin)
Online Accessible Chemical Databases
  Main website: http://www.mdpi.org/forum.htm#chemicals
  Author(s): (Shu-Kun Lin)
Other topics:
Electronic Conferences on Chemistry
Mailing Lists of Chemistry
Chemical Software (Several papers)
  Chemical Java Applets
  Web-Based Electronic Laboratory Notebook
Online Chemistry Books
  Web-Reprints of Classical Works
  New Web-Based Books

Databases, websites related to chemistry are very dynamic,
ever growing or updating. Let us have a snapshot once every year
so that some decades late, to say in 2100, our grand children
will have a chance to see how things on the then primitive
and exciting internet going. Internet is a large stride
of a revolution towards information freedom.

The "Annual Review of Chemical Resources on the Internet" also
serves as records of the overview of the work of
chemistry internet pioneers.

Submitted papers can be stored locally on your server.
If possible, with the permission of the webmaster,
download and store the related websites and put
them into your local server

The style of the papers should be like that of
http://www.unibas.ch/mdpi/molecules/papers/30100016/30100016.htm
Try to gather all the links to the "References and Notes"
section.

The first one will be published as a special issue of Molecules
(http://mdpi.org/molecules/) in December 1999. If
it its volume is very large, we may treat it as an online
book.

Interested authors are invited to prepare a chapter. One
chapter in the final book is regarded as an independent
review paper for Molecules. please contact by e-mail with me
for further information.

Shu-Kun Lin
Managing Editor
Molecules (ISSN 1420-3049, CODEN: MOLEFW)
http://www.mdpi.org/molecules/





From owner-repertoires@net.bio.net Fri Jul 16 16:12:00 1999
Path: biosci!biosci!not-for-mail
From: Kim Takita <kmtakita@KNOWLEDGEFOUNDATION.COM>
Newsgroups: bionet.molecules.repertoires
Subject: Single Molecule Analysis & Emerging Applications
Date: 16 Jul 1999 10:12:46 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 32
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Approved: a.wallace@qub.ac.uk
Distribution: world
Message-ID: <4.1.19990715104402.009379c0@192.168.0.10>
NNTP-Posting-Host: net.bio.net

Single Molecule Analysis & Emerging Applications
August 19-20, 1999, Boston, MA
Will observing and manipulating some of the smallest building blocks of
biological and synthetic materials lead to new applications and
technologies?
New analytical approaches is now the focus of intense research as
organizations
look to real-world applications to take advantage of exciting advances
in
single-molecule detection. Find out how single molecule research can
benefit
biotechnology, biomedicine, forensics, materials science, molecular
electronics
and molecular machines.
Conference website: http://www.knowledgefoundation.com/molecule.html

If you have any questions, or if you would like to receive a brochure,
please
feel free to contact me (see below).  Thank you!
----------------------------------------
Kim Takita
Vice President
The Knowledge Foundation
101 Merrimac Street
Boston, MA  02114
617-367-7979 ext. 202
617-367-7912 (fax)
Email:  kmtakita@knowledgefoundation.com
http://www.knowledgefoundation.com




From owner-repertoires@net.bio.net Mon Jul 26 09:37:00 1999
Path: biosci!biosci!not-for-mail
From: "Dr. Wendy A. Warr" <wendy@warr.com>
Newsgroups: bionet.molecules.repertoires
Subject: Meetings, news, vacancies...
Date: 26 Jul 1999 03:37:32 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 33
Sender: daemon@net.bio.net
Approved: A.Wallace@Queens-Belfast.AC.UK
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Message-ID: <379A12CC.74DF@warr.com>
NNTP-Posting-Host: net.bio.net

Featured on Warr Zone:

Celltech Merger with Chiroscience Group
TerraGen Acquisitions
Zeneca Specialties
Patenting of Combinatorial Chemistry
Therapeutic Antibodies to Merge with Proteus
ComGenex Procures CE mark for MultiReactor
ComGenex and Rhone-Poulenc Agro Establish Combichem Collaboration
Organic Letters Web Edition Goes Live
http://www.warr.com/warrzone.htm

Meetings updated at
http://www.warr.com/meet99.html
and
http://www.warr.com/meet00.html

Job vacancies at
http://www.warr.com/vacancies.htm

A few other things have changed too. Have a look.

Wendy
--
Dr Wendy A Warr
Wendy Warr & Associates, 6 Berwick Court
Holmes Chapel, Cheshire CW4 7HZ, England
Tel/fax +44 (0)1477 533837
wendy@warr.com   http://www.warr.com





From owner-repertoires@net.bio.net Mon Jul 26 10:16:00 1999
Path: biosci!biosci!not-for-mail
From: george sibbald <geos@goldrush.com>
Newsgroups: bionet.molecules.repertoires
Subject: MSA Portland Meeting Invitation: In Vitro AFM Force Spectroscopy
Date: 26 Jul 1999 04:16:07 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 43
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NNTP-Posting-Host: net.bio.net

SUBJECT:    "Studying Antibody-Antigen Interactions Using Atomic Force
Microscopy"

Dear Colleague

The paper below shows why this new field of microscopy and molecular
manipulation is becoming important to single molecule biological research.

This e-mail is to invite you to discuss "Antibody-Antigen Interactions Force
Spectroscopy Using Atomic Force Microscope" on August 2 through 5, 1999, at
the Molecular Imaging Booth # 213.

I hope to see you at MSA in Portland OR, but if you can not make it and need
further information please e-mail  info@molec.com.

Sincerely
George Sibbald,  President

Molecular Recognition Force.Microscopy/Spectroscopy
Peter Hinterdorfer, Anneliese Raab, Hansgeorg Schindler;  University of
Linz.
Characterization of molecular recognition on single molecular complexes.
Properties measured: kinetics(kon, koff), molecular dynamics(msec),
interaction forces.
"Pull" Force Spectroscopy: Antibody antigen binding force 
characterization
images in vitro shows both force and topographical images as well as binding
event timing.
http://www.molec.com/biology/antibody/index.html

Biological Measurements and Forces in AFM
Stuart Lindsay, Wenhai Han, and Yanzhang Liu;  Arizona State University
Protein unfolding may play a vital role in protein function (Soteriou,
Clarke et al. 1993)., Rief et al. (Rief, Gautel et al. 1997) demonstrated
that the AFM could be used to follow the unfolding of a single protein
molecule trapped between the AFM probe and a gold surface
http://www.molec.com/newsletters/spring98/npage1.htm







From owner-repertoires@net.bio.net Mon Jul 26 10:18:00 1999
Path: biosci!biosci!not-for-mail
From: "Dr. Wendy A. Warr" <wendy@warr.com>
Newsgroups: bionet.molecules.repertoires
Subject: Lead optimization libraries
Date: 26 Jul 1999 04:18:05 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
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If your company wants to make lead optimization libraries for another
company, or if you can recommend such a "contractor", please contact me
personally (wendy@warr.com). Please don't hit the reply button and annoy
other subscribers.

Wendy
--
Dr Wendy A Warr
Wendy Warr & Associates, 6 Berwick Court
Holmes Chapel, Cheshire CW4 7HZ, England
Tel/fax +44 (0)1477 533837
wendy@warr.com   http://www.warr.com





From owner-repertoires@net.bio.net Thu Jul 29 12:27:00 1999
Path: biosci!biosci!not-for-mail
From: "Rich Lysakowski, Ph.D." <rich@CENSA.ORG>
Newsgroups: bionet.molecules.repertoires
Subject: ACS Short Course on "Electronic Notebooks and Knowledge Management
Date: 29 Jul 1999 06:27:22 -0700
Organization: BIOSCI International Newsgroups for Molecular Biology
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Dear Colleague,

Attend the following exciting short course to be held in New Orleans, LA
on Friday, August 20th and Saturday, August 21st.

It is held two days before the start of the ACS Fall National Meeting.

Please register directly with the American Chemical Society using the phone
number at the end of this message.

Please register right away because open slots will fill up soon.

American Chemical Society (ACS) Continuing Education - Short Courses

"ELECTRONIC LAB NOTEBOOK AND KNOWLEDGE MANAGEMENT
SYSTEMS IN RESEARCH AND DEVELOPMENT"

This exciting and fast-moving course will captivate anyone needing to
know the legal, regulatory, technical, and social aspects of electronic
notebooks, recordkeeping, groupware, document management,
or other collaborative systems used in R&D or technical organizations.

It covers advanced automation technologies and concepts leading
to highly collaborative, knowledge-based R&D organizations.  It explains
and gives examples of the the latest concepts for electronic recordkeeping,
archving, electronic books and notebooks, and project data handling
systems tied into collaborative infrastructures.

WHO SHOULD ATTEND

Scientists, managers, engineers, MIS and computer support, librarians and
notebook administrators, archivists, knowledge managers, patent attorneys,
and industry regulators in the chemical, pharmaceutical, environmental,
biotech, food and beverage, aerospace, automotive, and related industries,
universities or government labs.

HOW YOU'LL BENEFIT FROM THIS COURSE

Stay current with the latest technologies, regulations, and legal
imperatives for laboratory recordkeeping.

Lead your company into the electronic recordkeeping age by
understanding critical requirements.

Quickly assess your company's infrastructure and cultural readiness to
use electronic lab notebooks; learn how to prepare them if they are not.

Learn how to enroll your Legal and Regulatory Affairs Departments as
partners rather than adversaries.

Learn when to buy versus build systems; how to grow them into
bull-blown R&D team computing systems for managing organizational
knowledge.

Get practical tips for evaluating and selecting vendors and systems.

See key products evaluated and demonstrated without vendor hype.

Receive top-notch materials and other resources to deepen your
understanding of concepts and systems in this course.

COURSE TOPICS

What are "electronic lab notebooks" and "R&D team computing systems?"

What is "knowledge management," its practices, and technologies?

How do these compare with groupware, document management,
collaborative computing, and other advanced automation tools?

Bottom-line business benefits and costs of systems and applications.

"Best practices" for R&D and testing laboratory recordkeeping.

The 13 fundamental properties of electronic records management systems
and organizations.

Electronic signature and notary systems and products available.

Satisfying the latest FDA, EPA, and Patent Office recordkeeping
regulations with electronic records and signatures.

Receive a seasoned interpretation of FDA's Rule 21 CFR Part 11 and
how to comply with it.

Basic and advanced technical system requirements.

Design and usability features that will "make or break" your projects.

How to move through potential cultural barriers to electronic notebooks
and other electronic collaboration systems.

Case studies and end-user experiences with home-brew and commercial
systems.

How to critically evaluate vendors and commercial products for fit.

A sampling of tools, technologies, and approaches for building systems.


THE INSTRUCTORS

This course is taught by two highly experienced automation specialists and
teachers with over two decades each of experience solving automation
problems.

Dr. Richard Lysakowski is the Executive Director of the Electronic Notebook
Systems Association, an international industry association dedicated to
market
development of electronic notebook systems and related systems for
laboratory
and R&D automation.

Dr. James T. Currie Jr. is a laboratory automation consultant and expert
who has
implemented many systems automated in validated environments.  He has been
involved in all phases of product and system development for many LIMS,
instrument interfacing, and related systems.

To register or to obtain additional information, e-mail us at
shortcourses@acs.org. Or, call us at 800-227-5558, ext. 4508, or
202-872-4508.





