From owner-molreps@hgmp.mrc.ac.uk Mon Nov 1 11:15:22 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 6F85017A62; Mon, 1 Nov 1999 11:15:21 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id LAA08291 for ; Mon, 1 Nov 1999 11:15:19 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id LAA00583 for molreps-list@hgmp.mrc.ac.uk; Mon, 1 Nov 1999 11:15:18 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: BIOSCI Administrator X-Newsgroups: bionet.molecules.repertoires Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 1 Nov 1999 02:55:54 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 242 Distribution: world Message-ID: <199910280900.CAA10051@net.bio.net> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk (LAST REVISION: 14-AUG-99) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- All BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- the UK-HGMP-Resource Centre (known as hgmp.mrc.ac.uk): ----------------------------------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@hgmp.mrc.ac.uk. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to majordomo@hgmp.mrc.ac.uk. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Please ask for help at biosci@hgmp.mrc.ac.uk if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. From owner-molreps@hgmp.mrc.ac.uk Mon Nov 1 12:45:26 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id E768717A43; Mon, 1 Nov 1999 12:45:25 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id MAA14660 for ; Mon, 1 Nov 1999 12:45:23 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id MAA01690 for molreps-list@hgmp.mrc.ac.uk; Mon, 1 Nov 1999 12:45:22 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: "z. g. zhao" X-Newsgroups: bionet.molecules.repertoires Subject: Fwd --- new software- Date: 1 Nov 1999 04:33:01 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 29 Distribution: world Message-ID: <3815D4B7.A49AC5FB@azcc.arizona.edu> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk I would be obliged if you could post the following message on the list. I tried direct posting but the message was rejected. Peter Bladon ---------------------------------------------- Subject INTERCHEM Software This is to announce the availability of the latest version of INTERCHEM Molecular Modelling Software. This includes databases containing 450,000 small molecule structures. For details see the URL: http://interchem.chem.strath.ac.uk/inter/interprobe.html I have aimed this message at several bulletins, so please accept my apologies if you receive several copies! Peter Bladon ---------------------------End of Message for Posting----------------------- From owner-molreps@hgmp.mrc.ac.uk Tue Nov 2 16:05:24 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 29E1F17A64; Tue, 2 Nov 1999 16:05:23 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id QAA25639 for ; Tue, 2 Nov 1999 16:05:22 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id QAA00526 for molreps-list@hgmp.mrc.ac.uk; Tue, 2 Nov 1999 16:05:20 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: "Dr. Philippe Silar" X-Newsgroups: bionet.molecules.repertoires Subject: reprint request Date: 2 Nov 1999 07:47:30 -0800 Organization: Institut de =?iso-8859-1?Q?G=E9n=E9tique?= et Microbiologie Lines: 12 Distribution: world Message-ID: <381EAFB3.5F62356B@igmors.u-psud.fr> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk Dear colleague, I am unable to get rapidly a reprint of the following paper by wang et al. (in J. Nat. Prod. 1997 60(6):629-631; anserinones A and B: new antifungal, antibacterial benzoquinones from the corpophilous fungus Podospora anserina). I would be very grateful if somebody can send me a PDF file of this paper. Thnak you, Pr. P. Silar From owner-molreps@hgmp.mrc.ac.uk Mon Nov 8 15:11:07 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 695C617A8A; Mon, 8 Nov 1999 15:11:06 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id PAA05562 for ; Mon, 8 Nov 1999 15:11:03 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id PAA04611 for molreps-list@hgmp.mrc.ac.uk; Mon, 8 Nov 1999 15:11:01 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Yoshihisa Inoue X-Newsgroups: bionet.molecules.repertoires Subject: The 9th Meeting of Japan Combinatorial Chemistry Focus Group (JCCF9) Date: 8 Nov 1999 06:48:50 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 110 Distribution: world Message-ID: <199911050004.JAA15398@gccss2.yoshitomi.co.jp> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk Dear Netters, We are pleased to announce that Japan Combinatorial Focus Group, JCCF, will hold the 9th JCCF Meeting on November 10-11 at Kanagawa Science Park (KSP) in Kawasaki near Tokyo, Japan. And we have to say sorry that if you want to present your products at the booths, all the 30 booths are occupied already. Please try next meeting in Osaka in April. **************************************************************** 9th Meeting of Japan Combinatorial Chemistry Focus Group **************************************************************** November 10-11 Kanagawa Science Park (KSP), Kawasaki, Kanagawa, Japan [Wednesday, November 10] 10:00-10:10 [Opening remark] (JCCF) Takashi Takahashi 10:10-10:55 IL-1 Strategies for the Synthesis and Characterization of Hundreds to Thousands of Discretes (GlaxoWellcome) Sam Gerritz 10:55-11:20 O-1 Synthesis of Arginin Vasopressin Antagonist Using Combinatorial Chemistry Technology (Yamanouchi Pharm.) Hiroyoshi Yamada,* Yoshiaki Shimada, Akihiro Tanaka 11:20-12:05 IL-2 Efficient Parallel Synthesis (Axys Advanced Technologies) Barry A. Bunin 12:05-14:00 [LUNCH / Vendor demonstration] 14:00-14:25 O-2 The Synthesis of Peptide Mimetics: A Library of Serine Protease Inhibitor (Tokyo Inst. Tech.) Takashi Takahashi, Nibuhiro Fuchi, * Takayuki Doi (Molecumetics) Michael Kahn 14:25-14:50 O-3 Efficient Strategies Towards Quality Compound Libraries and Their Impact in Lead Discovery-and Optimization (Polyphor Ltd) Daniel Obrecht,* Christine Abrecht, B. Dhanapal, P. Ermert, J.-P. Obrecht, K. Sekanina 14:50-15:15 IL-3 title to be announced (Shanghai Institute of Materia Medica) Jing-Kang Shen 15:15-15:25 refresh time 15:25-15:50 O-4 Organic Synthesis Based on Affinity Separation (Osaka Univ.) Koichi Fukase*, San-qi Zhang, Shoichi Kusumoto 15:50-16:50 IL-4 Recyclable Polymer Supported Chiral Auxiliaries (Oxford Univ.) Stephen G. Davies 17:00- mixer [Thursday, November 11] 09:30-10:15 IL-5 The Importance of New Technology in Accelerating Drug Discovery: Automation, Informatics and Parallel Synthesis (Cambridge Discovery)David Tapolczay 10:15-10:40 O-5 Automated Exact Mass Measurement of Combinatorial Libraries by ESI-TOF-MS (JASCO International Co.) Hideto Kakimi,* Sanae Furusho 10:40-11:05 O-6 Identification and Optimization of Drug-Like Leads (Tripos, Inc.) Edward Hodgkin 11:05-11:50 IL-6 Novel Approach to the Development of Drugs that Target Transcription Factors (Tokyo Inst. Tech.) Hiroshi Handa 11:50-14:00 [LUNCH / Vendor demonstration] 14:00-14:25 O-7 Library Registration & Design Using Chem-X (Oxford Molecular) Stephen J. Cato 14:25-14:50 O-8 Managing the Workflow of a High-Throughput Organic Synthesis Laboratory: A Marriage of Automation and Information Management Technologies. (Molecumetics) Burt Goodman 14:50-15:15 O-9 Click Chemistry: Process Driven Drug Discovery (Coelacanth) Hartmuth Kolb 15:15-16:00 IL-6 Palladium Catalysis in Water: A Combinatorial Approach to Water-Based Catalytic Asymmetric Reactions (Nagoya City Univ.) Yasuhiro Uozumi 16:00- [Closing remark] (JCCF) Koichi Fukase For details, please visit the JCCF homepage. The URL is http://www.orgsyn.riken.go.jp/CombiChem.html. FAX:+81(Japan)-6-6443-6685 Email: jccf@yo.rim.or.jp \ / _ / / Yoshihisa INOUE, Yoshitomi Pharcaceut.Ind., Ltd. \ / / / / 2-25-1 Shodai-Ohtani,Hirakata,Osaka 573-1153 JAPAN / ____/ / tel: +81-720-56-9328 / / / fax: +81-720-68-9597 _/ __/ __/ E-mail: inouey@yoshitomi.co.jp From owner-molreps@hgmp.mrc.ac.uk Mon Nov 8 19:25:21 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 9D11C17A60; Mon, 8 Nov 1999 19:25:20 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id TAA22209 for ; Mon, 8 Nov 1999 19:25:17 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id TAA07944 for molreps-list@hgmp.mrc.ac.uk; Mon, 8 Nov 1999 19:25:16 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Shu-Kun Lin X-Newsgroups: bionet.molecules.repertoires Subject: MolMall - Rare Chemical Samples Database on the Internet Date: 8 Nov 1999 09:18:42 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 33 Distribution: world Message-ID: <382329B3.C309AC63@mdpi.org> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk You may easily search for samples you need at MolMall (http://www.molmall.org), the Rare Chemical Samples Exchange Center. You may do full structure search or substructure search on the website. You may search for name of the submitter. E.g., at "Power Search", you put LIN as the query, you will find a list of 8 structures (Lin contributed 8 samples). There other very useful searching functions. More detailed data sheet regarding a sample is available by clicking on the number. Direct link to published paper was made. However, so far there are only links to Molecules MolBank (http://www.molbank.org) papers if the compounds are published there. We also plan to allow he sample submitters to add additional information to the data sheet, such as the literature where the compound was published. Any suggestions? Have fun! Shu-Kun -- Dr. Shu-Kun Lin Molecular Diversity Preservation International (MDPI) Saengergasse 25, CH-4054 Basel, Switzerland Tel. +41 79 322 3379, Fax +41 61 302 8918 E-mail: lin@mdpi.org http://www.mdpi.org/lin/ From owner-molreps@hgmp.mrc.ac.uk Mon Nov 8 23:40:10 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id EFB5E17A60; Mon, 8 Nov 1999 23:40:09 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id XAA06397 for ; Mon, 8 Nov 1999 23:40:04 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id XAA19272 for molreps-list@hgmp.mrc.ac.uk; Mon, 8 Nov 1999 23:40:03 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: "Dr. Wendy A. Warr" X-Newsgroups: bionet.molecules.repertoires Subject: News items Date: 8 Nov 1999 06:44:25 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Distribution: world Message-ID: <3821DEBC.4622@warr.com> Lines: 32 To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk Some recent news items at http://www.warr.com/warrzone.htm Argonaut and Symyx Sell Instruments for Combinatorial Chemistry Spotfire and Oxford Molecular Group Integrate Software Oxford Molecular launches RS3 Discovery for Excel Cambridge Combinatorial Announces Name Change Alliance of Cambridge Discovery Chemistry and Lancaster Synthesis News from LHASA Ltd Intranet International 2000: a New Conference Announced Annual General Meeting of the Pharma Documentation Ring Roche, Parke-Davis and Ribotargets Award Additional Contracts To Biofocus Annual Reports in Combinatorial Chemistry and Molecular Diversity ChemConnect Announces Successful Second Round of Capital Funding Beilstein Abstracts Now Free of Charge to Members of ChemWeb.com ChemWeb Launches Catalysis Forum New Version of Marvin Java Applets Latest Issue in the Current Trends Series Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-molreps@hgmp.mrc.ac.uk Tue Nov 9 10:42:59 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id D950217A61; Tue, 9 Nov 1999 10:42:58 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id KAA06990 for ; Tue, 9 Nov 1999 10:42:56 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id KAA27406 for molreps-list@hgmp.mrc.ac.uk; Tue, 9 Nov 1999 10:42:55 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Daniel Keppler X-Newsgroups: bionet.molecules.repertoires Subject: Re: BclI endonuclease Date: 9 Nov 1999 02:33:42 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 25 Distribution: world Message-ID: <0.000135A5@listserv.rl.ac.uk> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk Bcl-I is methylation sensitive; try using dam- bacteria. Yung Kim wrote: > > Hi, > > In our lab we are using BclI restriction enzyme to cut a plasmid, but somehow we failed with a couple of newly purchased BclI enzymes, although it was confirmed that the enzyme recognition site is intact through sequencing. Does anyone have experience with BclI or suggestion? I'll appreciate your advice. > > Yung Hae Kim > Oral Molecular Biology > Oregon Health Science Univ. -- Daniel Keppler, Ph.D. Tel.: (313) 577-0514 (office) Assistant Professor (313) 577-0941 (laboratory) Department of Pharmacology and Fax: (313) 577-6739 (department) Karmanos Cancer Institute E-mail: dkeppler@med.wayne.edu Wayne State University Internet:http://www.med.wayne.edu/pharm/ School of Medicine 540 E. Canfield Avenue Detroit, MI 48201 From owner-molreps@hgmp.mrc.ac.uk Tue Nov 9 16:07:05 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 1BAFF17A43; Tue, 9 Nov 1999 16:07:03 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id QAA03105 for ; Tue, 9 Nov 1999 16:07:00 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id QAA02411 for molreps-list@hgmp.mrc.ac.uk; Tue, 9 Nov 1999 16:06:59 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Yung Kim X-Newsgroups: bionet.molecules.repertoires Subject: BclI endonuclease Date: 9 Nov 1999 02:27:38 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 15 Distribution: world Message-ID: <199911081829.SAA00830@fujin.qub.ac.uk> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk Hi, In our lab we are using BclI restriction enzyme to cut a plasmid, but somehow we failed with a couple of newly purchased BclI enzymes, although it was confirmed that the enzyme recognition site is intact through sequencing. Does anyone have experience with BclI or suggestion? I'll appreciate your advice. Yung Hae Kim Oral Molecular Biology Oregon Health Science Univ. From owner-molreps@hgmp.mrc.ac.uk Fri Nov 12 12:15:40 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id DE90217A67; Fri, 12 Nov 1999 12:15:35 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id MAA19758 for ; Fri, 12 Nov 1999 12:15:29 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id MAA16871 for molreps-list@hgmp.mrc.ac.uk; Fri, 12 Nov 1999 12:15:28 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Marcel Dinger X-Newsgroups: bionet.molecules.repertoires Subject: Genamics JournalSeek Date: 12 Nov 1999 04:03:29 -0800 Organization: The Internet Group (Hamilton) Lines: 19 Distribution: world Message-ID: <942347887.772776@ham.ihug.co.nz> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk GENAMICS JOURNALSEEK The largest journal information database on Earth. Check it out now at: http://genamics.com/journals/ Genamics JournalSeek is a fully searchable database of journal information. JournalSeek now contains over 8500 journal titles. Information includes abbreviated titles, aims and scope, publisher, link to online site, availability of abstracts/full-text online, ISSNs, and journal impact factors. All information is freely provided. Marcel Dinger, Genamics. http://genamics.com From owner-molreps@hgmp.mrc.ac.uk Mon Nov 15 21:42:11 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 50D4717A8A; Mon, 15 Nov 1999 21:42:11 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id VAA09745 for ; Mon, 15 Nov 1999 21:42:09 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id VAA18977 for molreps-list@hgmp.mrc.ac.uk; Mon, 15 Nov 1999 21:42:09 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Mark Suter X-Newsgroups: bionet.molecules.repertoires Subject: Postdoctoral position to study immune response against herpesvirus. Date: 15 Nov 1999 13:22:23 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 40 Distribution: world Message-ID: To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk We study the immune response against herpes simplex virus 1 (HSV-1) and pseudorabies virus using in vivo (J. Virol. 73:4748) or in vitro dendritic cell systems (Eur. J. Immunol. 29:3245). Replication competent virus (J. Virol. 73:4748) or a novel DNA vaccination approach based on the entire HSV-1 genome deliverd as bacterial artificial chromosome (PNAS, 96: 12697) are used for immune-stimulation. Begin: January 2000; for one year with the possibility for extension . Salary: Based on the regulation of the Swiss National Science Foundation. Interested candidates with a strong background in immunology or molecular biology, please send CV and bibliography to: Dr. Mark Suter University Institute for Virology Winterthurerstr. 266a 8057 Zurich SWITZERLAND Telephone: (+41) 1 6358717 Faximile : (+41) 1 6358911 mailto:msuter@vetvir.unizh.ch http://www.unizh.ch/vetvir \|/ (o o) ________________________________oOo__(_)__oOo_________________________________ ___/\_ | Mark Suter mailto:msuter@vetvir.unizh.ch / o \/| | University Inst.for Virology http://www.unizh.ch/vetvir / _| | Winterthurerstr. 266a Telephone: (+41) 1 6358717 /_/\__/-\/ | 8057 Zurich SWITZERLAND Faximile : (+41) 1 6358911 ______________________________________________________________________________ If it wasn't for Windows, we wouldn't have anything to compare Mac's to ______________________________________________________________________________ From owner-molreps@hgmp.mrc.ac.uk Wed Nov 17 09:40:54 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 33E1617A63; Wed, 17 Nov 1999 09:40:52 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id JAA15957 for ; Wed, 17 Nov 1999 09:40:50 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id JAA24787 for molreps-list@hgmp.mrc.ac.uk; Wed, 17 Nov 1999 09:40:49 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Michael Sherrell X-Newsgroups: bionet.molecules.repertoires Subject: ABI 3948 for sale Date: 17 Nov 1999 01:31:12 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 14 Distribution: world Message-ID: <003101bf3099$db84b460$d1c9aec7@rossbranch> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk ABI 3948 available, ~ 2 yrs. old, running well in Midwestern lab, ~US$105,000. Michael Sherrell Grizzly Analytical (USA) 707 887 2919/fax 707 887 9834 www.grizzlyanalytical.com PS -- for other sequencers, synthesizers, mass specs and NMRs, see the website. From owner-molreps@hgmp.mrc.ac.uk Mon Nov 29 12:45:16 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 2E6E517A43; Mon, 29 Nov 1999 12:45:15 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id MAA09179 for ; Mon, 29 Nov 1999 12:45:13 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id MAA05295 for molreps-list@hgmp.mrc.ac.uk; Mon, 29 Nov 1999 12:45:12 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: "Dr. Wendy A. Warr" X-Newsgroups: bionet.molecules.repertoires Subject: What is Cheminformatics? Date: 29 Nov 1999 04:30:41 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 45 Distribution: world Message-ID: <38406DAF.2DFE@warr.com> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk Please excuse duplicate postings. My thanks to everyone who sent me data, opinions, and job descriptions for my talk in New Orleans on the discipline of cheminformatics and the shortage of skilled staff in that field. I promised to summarize it all for the lists but that is very difficult in view of the sheer volume of information involved. About two years ago, many people (including myself) considered that "cheminformatics" was a nasty neologism. My survey this summer shows that it is now an established discipline, although the tasks involved, and even the name of the discipline, are not clearly defined yet. "Cheminformatics" was preferred to "chemoinformatics" by most respondents. One company uses "chemiiinformatics". There is still much distaste for the job title "cheminformatician". A zipped file of my PowerPoint slides is available on my Web site http://www.warr.com/ I have been waiting for COMP Division to put all the slides from this Symposium on the COMP web site at http://membership.acs.org/C/COMP/ Unfortunately I think that this has not happened - though at least four of the main headings on that home page give "404 Not Founds", so perhaps the material is there but temporarily hidden. My sincere thanks to all of you who helped in this survey. Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com From owner-molreps@hgmp.mrc.ac.uk Tue Nov 30 18:15:33 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 9712D17A7C; Tue, 30 Nov 1999 18:15:32 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id SAA00896 for ; Tue, 30 Nov 1999 18:15:30 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id SAA07508 for molreps-list@hgmp.mrc.ac.uk; Tue, 30 Nov 1999 18:15:28 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: Peter Butler X-Newsgroups: bionet.molecules.repertoires Subject: Molecular Diversity - Available Online Date: 30 Nov 1999 10:16:18 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 66 Distribution: world Message-ID: To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk We are pleased to announce that the journal "Molecular Diversity" is available online to Institutional Subscribers. Please visit the Journal's homepage for further details: http://www.wkap.nl/journals/molecular_diversity Kind regards, Peter Butler Publishing Editor peter.butler@wkap.nl ================================================================== Some of the consequences/advantages: * Articles are loaded as character-based PDF files * Articles available up to 4 weeks in advance of print * Coverage dates back to 1997 (as available) 1997-98 issues included with 1999 subscription rences from: CSA, ChemPort, SilverLinker, Web of Science * Permits powerful fielded searching using Boolean operators Access: * Access granted to institutions (regardless of size), not individuals * Authentication by domain names/IP range: (no IDs/passwords required) * Authorized users include: - faculty (permanent and visiting) - staff (full- and part-time) - students (full- and part-time) - remote users (must access through institution’s registered domain name/IP range) * Campus-wide, simultaneous access Pricing: * Priced for content: electronic costs same as print (no hidden costs) * Print plus electronic (dual access) available for 20% surcharge Licensing Models: * À la carte: pick and choose any journals, in any combinations of print/electronic * Site licenses: 75+ subscriptions (reduced dual-access surcharges available) * Consortium licenses: group--wide holdings access for all participants buy-in option for institutions with few subscriptions reduced dual-access surcharge available * Long-term licenses available, including price cap on subscription rate increases From owner-molreps@hgmp.mrc.ac.uk Tue Nov 30 18:15:33 1999 Return-Path: Delivered-To: molreps-archive@hgmp.mrc.ac.uk Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id ECBBC17A86; Tue, 30 Nov 1999 18:15:32 +0000 (GMT) Received: from niobium.hgmp.mrc.ac.uk (niobium [193.62.192.41]) by hgmp.mrc.ac.uk (8.9.3/8.9.3) with ESMTP id SAA00895 for ; Tue, 30 Nov 1999 18:15:29 GMT Received: (from news@localhost) by niobium.hgmp.mrc.ac.uk (8.9.3+Sun/8.8.8) id SAA07503 for molreps-list@hgmp.mrc.ac.uk; Tue, 30 Nov 1999 18:15:27 GMT X-Authentication-Warning: niobium.hgmp.mrc.ac.uk: news set sender to using -f From: "Dr. Wendy A. Warr" X-Newsgroups: bionet.molecules.repertoires Subject: cheminformatics slides Date: 30 Nov 1999 09:57:04 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 27 Distribution: world Message-ID: <3842F3DC.7C9C@warr.com> To: molreps@hgmp.mrc.ac.uk Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk You must all be back in the office after Thanksgiving! I am already getting replies about the slides mentioned in my last message. Two points of clarification: 1. Yes, there are more jobs going than candidates at the moment, and yes, they tend to learn on the job, but if universities start to train them, by the time they emerge in 4 years (?) time the whole situation could be quite different. So the current training situation of "sitting alonga Nellie" will probably persist. 2. "p.a." in Slide 22 means per annum. Apologies for duplicate messages. Wendy -- Dr Wendy A Warr Wendy Warr & Associates, 6 Berwick Court Holmes Chapel, Cheshire CW4 7HZ, England Tel/fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com