From owner-molreps@hgmp.mrc.ac.uk Fri Jun 9 08:06:29 2000 Return-Path: Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 110) id 9C0DB17AEF; Fri, 9 Jun 2000 08:06:28 +0100 (BST) Received: by mercury.hgmp.mrc.ac.uk (Postfix, from userid 60001) id 32A9117B5F; Fri, 9 Jun 2000 08:06:26 +0100 (BST) To: molreps@net.bio.net Newsgroups: bionet.molecules.repertoires From: Christine Dempster Subject: PHAGE Announcement Date: 9 Jun 2000 08:01:12 +0100 Organization: BIOSCI/MRC Human Genome Mapping Project Resource Centre Message-ID: Sender: owner-molreps@hgmp.mrc.ac.uk Precedence: bulk We appologize if you have received this announcement previously. Please pass it on to your colleagues. Thank you! June 1, 2000 -- Conference Announcement Phage Display Conference "Understanding Phage Display: Structure, Biology and Applications" Vancouver, British Columbia, Canada Thursday, September 21st through Saturday, September 23, 2000. --------------- Nature and Importance of the Conference: "Understanding Phage Display" -- its structure, biology and applications is the focus of a conference on Phage Display which will be held in Vancouver, Canada this September. There are currently about 4-6 meetings on Phage Display per year; however, none of them address the biological or structural bases of the technology. Each session of the Vancouver conference will combine talks on the basic science of a given aspect of phage biology pertinent to phage display with talks on applications of phage display technology to problems in biomedicine, structural biology, biochemistry, etc. The reason for this plan is to lead the speakers and audience into a natural discussion of biological and structural constraints of phage display and, perhaps, to new ideas on how to overcome or circumvent them. We have deliberately planned a small conference -- with an anticipated attendance of 150 delegates -- so that we can create a 'workshop' atmosphere. ------------------------------- Tentative Program (this program is subject to change): THURSDAY 21 September 2000: 6:00-7:00 pm: Welcome reception/registration 7:00 pm: Opening remarks - L. Makowski* 7:15 pm: Phage structure and biology I: constraints on phage display Biology of filamentous phage - structure and life cycle - R. Webster* Phage assembly & its relation to the protein secretory process - M. Russel* FRIDAY 22 September 2000: Phage, pVIII display and structural biology (S. Opella chair) NMR studies of pVIII and of pVIII-displayed peptides - S. Opella* X-ray structure of phage coat - L. Makowski* Constraints of pVIII on phage display - R. Perham * Engineering the M13 Coat for Improved Phage Display- S. Sidhu* Morning Break Phage, pVIII display and structural biology - Continued (S. Opella chair) Homodimeric peptides displayed on pVIII - M. Zwick* Display at different positions of pVIII and the design of mosaic phage - V. Petrenko* Role of phage in in-solution structure determination of biopolymers by NMR - A. Pardi* and G. Clore* Lunch (on own) Biology and structure of pIII and applications to phage display (R. Perham*, chair): structure of pIII and infection - L. Riechmann/P. Holliger, R. Perham*, Lubkowski pIII and release of phage from the cell - P. Model* structure of the F pilus and infection - L. Frost* Afternoon Break Biology of other coat proteins and application to phage display (P. Model*, chair) pVI, pVII and pIX structure and function - P. Model* pVI-display libraries - M. Fransen* pIX- and pVII-display libraries - K. Janda* Poster Session/Reception SATURDAY 22 September 2000: Novel means of phage display (A. Plueckthun*, chair) selectively-infective phage - C. Borrebaeck infection via altered pilin proteins - C. Borrebaeck cDNA-fragment libraries displayed via fos/jun - R. Crameri* phage display via surrogate coat proteins - D. McGregor* Morning Break Novel means of selection from phage-display libraries I (G. Smith*, chair) panning and biopanning/ gene-fragment libraries - G. Smith* selection of cDNAs and Abs that mediate entry of phage into eukaryotic cells - Molecular anatomy of blood vessels revealed by in vivo screening of phage-display libraries - R. Pasqualini* Lunch (on own) Novel means of selection from phage-display libraries II (C.F. Barbas, chair) selection of stably-folding (protease resistant) proteins - A. Plueckthun* Selection strategies for mapping protein-protein interactions- L. Jespers* frameshift and stop-codon mutations, ribosomal slippage and expression - W. Mandecki zinc-finger libraries and nucleic acid selections - C. Barbas* chemically reactive phage displaying seleno-cystine - C. Noren* Afternoon Break Round-table discussion on future work in phage display - R. Perham*, S. Opella*, G.P. Smith*, P. Model*, A. Plueckthun*, (R. Perham*, chair) [Session chairs will summarize the talks from their sessions, and then will open the floor for discussion. Emphasis should be on new insights that phage structure and biology can give to problems in phage display.] Closing remarks/acknowledgements - J. Scott* Saturday night banquet: G.P. Smith* address - the history of phage display * indicates people who have agreed to speak at the conference --------------------------------- Venue: The conference will be held at Simon Fraser University's, Harbour Centre campus located in the heart of downtown Vancouver. Conference Location and Accommodation: Framed by majestic mountains and the sparkling Pacific Ocean, and offering a blend of European, Canadian and Pacific Rim cultures, Vancouver has a cosmopolitan lifestyle that you'll enjoy and remember. Conference accommodation has been chosen that will offer delegates a good selection of hotels within easy walking distance of the downtown campus. Prices will range from $50 - $205 Canadian dollars per night. --------------------------------------- Conference Registration Fees: We anticipate that conference fees will be approximately $250 US. There will be a lower fee for students. These fees will not include accommodation or airline travel. ----------------------------------- General Conference Enquiries and Registration Information: To receive further information on the conference including a registration form, please send your mailing address ASAP or by June 23rd, 2000 to: Conference Services Simon Fraser University Halpern Centre 8888 University Drive Burnaby, B.C. V5A 1S6 Canada Phone: 604-291-4910 or 291-3012; Fax: 604-291-3420 Email: Conference_Services@sfu.ca The detailed brochure will only be mailed to those people who have requested additional information. We look forward to seeing you in Vancouver in September. Jamie Scott, PhD, MD Conference Chair ---