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To: Dr.allen@mailexcite.com
Subject: Free Allergy Screening!
Message-ID: <0e6975930230548UPIMSRGSMTP07@msn.com>
Date: 5 Apr 1998 15:31:02 -0800

///////////////////////////////////////////////////////////////////////////////
You can now add allergy screening and custom immunotherapy to your practice-
and there are no upfront costs.

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programming, and significantly increased revenues for your practice.

Complete program includes training, laboratory based allergy screening, and
complete immunotherapy program in injection ready format.  See how "Allergy
Treatment is Made Easy" through the BioSafe, "Is Life Making You Sick" allergy
treatment program.

Register for your free allergy screening kits and complete information
package:

http://www.freeyellow.com/members2/allergen




From BIOSCI-REQUEST  Mon Apr  6 02:00:09 1998
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Date: Mon, 6 Apr 1998 02:00:05 -0700
From: BIOSCI Administrator <biohelp>
Message-Id: <199804060900.CAA08682@net.bio.net>
To: mutation@net.bio.net
Subject: BIOSCI/bionet miniFAQ & Fundraiser

(LAST REVISION: 30-JUL-95)

This BIOSCI "miniFAQ" is designed to answer the questions that come up
the *most frequently*.  The main BIOSCI FAQ (Frequently Asked
Questions) is accessible on the World Wide Web at URL
http://www.bio.net/.

If you can not find an answer to your question in this or other
documentation, the BIOSCI technical support staff answers e-mail
queries sent to

		       biosci-help@net.bio.net

We can only answer questions about the use of the newsgroups and
mailing lists.  We unfortunately do not have the staff to do Internet
information searches or answer scientific questions.  Please post
those to the appropriate BIOSCI/bionet newsgroups.


	Contents:
	--------
	0) BIOSCI NEEDS YOUR SUPPORT!!

	1) Using the WWW to access the BIOSCI/bionet newsgroups.

	2) What to do about "spams," i.e., junk mail, ads, etc.

	3) Examples of subscribing and unsubscribing to the mailing lists.

	4) The BIOSCI user address and research interest directory.


0) BIOSCI NEEDS YOUR SUPPORT!!
------------------------------
BIOSCI's government funding has been expended, and we are now
operating solely from advertising revenue that we have raised from our
Web site at http://www.bio.net/.  We need just a few minutes of your
time to help us serve you.

You can do two important things which will take very little time for
you individually and will immensely help us continue to help you.

First, please use our WWW system at http://www.bio.net/ to access the
archives.  You can post or reply to messages via your Web browser as
described in item #1 below.  Your usage helps attract sponsors. If you
contact any of our sponsors, please be sure to thank them for
supporting BIOSCI. It is critical for them to get this feedback if
they are to continue their sponsorship for the long term.

Second, if you work for a company or organization that provides
products or services of interest to the biology community, please pass
this message on to your marketing or marketing communications
department or other appropriate group.  Please ask them to help
support BIOSCI by sponsoring our Web site and explain the uses and
benefits of the system to the biology community. If they are
interested, they can then contact us for further information at our
tech support address, biosci-help@net.bio.net.


1) Using the WWW to access the BIOSCI/bionet newsgroups.
--------------------------------------------------------
As of 10 December 1995, all BIOSCI/bionet full newsgroups are
accessible through the World Wide Web (WWW) at URL http://www.bio.net.
One can read and reply publicly or privately to both recent postings
and archived messages through one's Web browser if it is configured
properly to send e-mail.  Each newsgroup is equipped with its own WAIS
index.  The main BIOSCI home page also has access to the BIO-JOURNALS
Table of Contents database WAIS index and the BIOSCI user address
database described in another item further below.


2) What to do about "spams," i.e., junk mail, ads, etc.
-------------------------------------------------------
BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups),
mailing lists, and a hypermail archive at URL http://www.bio.net/.
The same postings are distributed on all media (except for a small
number of mailing-list-only groups at net.bio.net).  Unfortunately it
is becoming a despicable practice on the Internet (by a few people out
to make a fast buck) to do automated mass postings to thousands of
newsgroups and mailing lists.  These attempts to grab free advertising
are refered to as "spams" in the usual, somewhat boneheaded, net
terminology.  USENET is more susceptible to this practice, and many
spams originate on the USENET groups and then are passed on to the
mailing lists.  However, spammers also get lists of mailing addresses
and hit these too, so neither medium is immune.

What should you do personally if you get junk mail?
---------------------------------------------------
Just delete it and move on without reading it further.  Filing a
protest is becoming increasingly useless because spammers are often
disguising the addresses where the messages are sent from.  Unless you
really understand Internet mail systems, your attempt at protest by
sending replies to the message will often end up being sent to the
address of an innocent person that the spammer is victimizing.

What can BIOSCI/bionet do to protect its newsgroups?
----------------------------------------------------
The only solution currently available is to moderate the newsgroup.
If this newsgroup is already moderated, then you are in good shape.
Moderation protects the USENET distribution from about 95% of the
spams that are being sent to date and protects the mailing lists
completely.  Moderation means, however, that someone has to take the
time to review each message before it goes out.  We have set up
software here that simply allows the moderator to forward to an
address at net.bio.net messages that (s)he wishes to have distributed.
This takes no more time than that needed to read the message and pass
it on, say about 1 min. per message.

Most newsgroups currently have a discussion leader who is responsible
for their newsgroup.  The discussions leaders and their e-mail
addresses are listed in the BIOSCI Information Sheet which is
available on the Web at http://www.bio.net/.  If a newsgroup is being
hit with too many junk postings, please contact the discussion leader
for that group and see if there is interest in moderating the group.
Please do not assume that by simply posting a complaint to the
newsgroup itself, anyone on the BIOSCI staff will act on your
complaint.  With close to 100 newsgroups to run, the BIOSCI staff has
to rely on the discussion leaders of each newsgroup to report problems
directly to us at biosci-help@net.bio.net.

We will moderate any of our newsgroups if the discussion leader tells
us that the readership of the group wishes to do so and if a moderator
is willing to do the work.  For most BIOSCI/bionet groups, this
entails only a few minutes of work each day.

Moderating a newsgroup will resolve probably 95% of the junk postings
on the USENET distribution.  Unfortunately there are easy ways for
determined spammers to override the moderation mechanism on USENET,
but we can protect our e-mail subscribers from unwanted postings if
the newsgroup is moderated.  You can also access our newsgroups over
the WWW at URL http://www.bio.net.  While this Web interface will not
stop spammers from trying to post to the groups, this will give you
yet another way, besides using USENET news, to keep the junk out of
your personal mail files.  For those of you with local USENET news
systems, the Web interface will also give you faster access to new
newsgroups and recent postings.


3) Examples of subscribing and unsubscribing to the mailing lists.
------------------------------------------------------------------
PLEASE NOTE: The BIOSCI management does NOT act on
subscription/unsubscription requests that are posted improperly to the
newsgroups and mailing lists.  People who do this only bother everyone
on the lists to no avail.  Please be sure to follow the proper
procedures below.

Gory details are in the BIOSCI Information sheets on the Web at
http://www.bio.net.  Below we give an example utilizing the
METHODS-AND-REAGENTS list at both of our two BIOSCI sites:

Users in the Americas and Pacific Rim countries who use the BIOSCI
------------------------------------------------------------------
node at computer net.bio.net:
----------------------------

A) Determine the "listname" which is the <=8 character mail address
                                         ^^^^^^^^^^^^^
   for the group.  These can be found in the BIOSCI Info. Sheet.  For
   the METHODS-AND-REAGENTS group the mailing address is
   methods@net.bio.net.  The listname is the portion of the address to
   the left of the @ sign, i.e., "methods".  The listname is used with
   the "subscribe" and "unsubscribe" commands illustrated below.

B) Mail all commands in the body of a mail message addressed to
   biosci-server@net.bio.net.  Do NOT send commands to the newsgroup
   posting addresses!  Leave the Subject: line blank, any text on it
   will be ignored.

C) In the body of your message put one or more of the following
   commands with an "end" command on the last line, e.g.,

   subscribe methods
   unsubscribe methods
   end

   Do NOT put your e-mail address or other text on these lines.  The
   server only allows you to cancel your subscription if the address
   on your mail header matches the address on our mailing list.
   Please ask for help at biosci-help@net.bio.net if your address has
   changed, e.g., if you know you are on the list but the server tells
   you that you are not a member.


Users in Europe, Africa, and Central Asia who use the BIOSCI node at
--------------------------------------------------------------------
computer daresbury.ac.uk (also known as dl.ac.uk):
-------------------------------------------------

To subscribe and unsubscribe to/from the BIOSCI lists, you need to
specify the full USENET newsgroup name with "bionet-news." prepended.
The USENET newsgroup names are listed in the BIOSCI Information sheet
on the Web at http://www.bio.net/.  For the METHODS-AND-REAGENTS list
the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the
appropriate commands are

    sub bionet-news.bionet.molbio.methds-reagnts

    unsub bionet-news.bionet.molbio.methds-reagnts

These commands are included in a message addressed to mxt@dl.ac.uk,
NOT to the newsgroup mailing addresses.  As usual, include the text in
the body of the message as text on the Subject: line is ignored.

To unsubscribe from all the lists at the UK node, use

    unsub bionet-news

Please note that if the address in the list is different than the one
in your mail message header, you will not be able to unsubscribe by
this method. If you have problems, please mail biosci@daresbury.ac.uk.


4) The BIOSCI user address and research interest directory.
-----------------------------------------------------------
Please take this opportunity to add your name, address, and research
interest information to the BIOSCI User Address Database if you have
not already done so.

You can fill out the address form directly through our Web page at URL
http://www.bio.net/adrform.html.

The address database is reindexed nightly for WWW access (the URL is
http://www.bio.net/).  If you are not directly on the Internet but can
reach it by e-mail, please use our waismail server to access the user
directory.  waismail use is described above.  You can also request a
user address form by e-mail from biosci-help@net.bio.net.

Please check your database entry from time-to-time to see if your
address information is still up-to-date.  Because of our limited
personnel resources, we ask that you resubmit a *complete* form to
revise your entry; we only replace complete entries and do not have
resources to edit old forms.


From BIOSCI-REQUEST  Mon Apr  6 09:30:41 1998
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Sender: lehvasla@ebi.ac.uk
Message-ID: <352902CC.214FEEF2@ebi.ac.uk>
Date: Mon, 06 Apr 1998 17:29:00 +0100
From: Heikki Lehvaslaiho <heikki@ebi.ac.uk>
Organization: EMBL - EBI
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To: mutation@net.bio.net
Subject: [Update] MutRes v. 1.3
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The number of databases in the searchable Mutation Resources list,
MutRes, 
has reached a round number, 100, so I thought this might be a good time
update the ftp server copy.

#Mutation Resources List (MutRes),  version 1.3  980406
#
Name    Mutation Resources List
Acc     M0000000
Type    database
Contact Heikki Lehvaslaiho
Address EMBL Outstation, European Bioinformatics Institute
Address Wellcome Trust Genome Campus, Hinxton
Address Cambs CB10 1SD, United Kingdom
Email   heikki@ebi.ac.uk
Fax     +44 (0)1223 494 644 
Phone   +44 (0)1223 494 468
Size    125 entries, 100 databases
URL    
http://srs.ebi.ac.uk:5000/srs5bin/cgi-bin/wgetz?-fun+Pagelibinfo+-info+MUTRES
URL     ftp://ftp.ebi.ac.uk/pub/databases/mutres/
Update  19971024
//
#
#
# Version history
#
# 1.2  971024  105 entries, 85 databases
# 1.3  980406  125 entries, 100 databases
#

Enjoy,
	-Heikki

______ _/      _/_____________________________________________________
      _/      _/                      http://www2.ebi.ac.uk/mutations/
     _/  _/  _/  Heikki Lehvaslaiho          heikki@ebi.ac.uk
    _/_/_/_/_/  EMBL Outstation, European Bioinformatics Institute
   _/  _/  _/  Wellcome Trust Genome Campus, Hinxton
  _/  _/  _/  Cambs. CB10 1SD, United Kingdom
     _/      Phone: +44 (0)1223 494 644   FAX: +44 (0)1223 494 468
___ _/_/_/_/_/________________________________________________________

From BIOSCI-REQUEST  Tue Apr  7 01:20:35 1998
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          with SMTP id JAA03325; Tue, 7 Apr 1998 09:18:55 +0100 (BST)
Message-ID: <3529E16F.1198@hgu.mrc.ac.uk>
Date: Tue, 07 Apr 1998 09:18:55 +0100
From: Alastair Brown <Alastair.Brown@hgu.mrc.ac.uk>
Reply-To: Alastair.Brown@hgu.mrc.ac.uk
Organization: MRC Human Genetics Unit
X-Mailer: Mozilla 3.01Gold (Win95; I)
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To: mutation@net.bio.net
Subject: Mutability Web Program
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I have written a very simple web-based program called "Mutability" which
will take a DNA sequence (typed or pasted into a web form) and determine
how many single point mutations would result in nonsense, missense, or
neutral mutations. It then displays the sequence with potential stops
and CpGs highlighted. The URL is:

    http://www.hgu.mrc.ac.uk/Softdata/Mutability/

Instructions and a more detailed description are at:

    http://www.hgu.mrc.ac.uk/Softdata/Mutability/muthelp.htm

It was written to satisfy a specific need here at MRC HGU, but it may be
of use to others. Regards.

Alastair Brown

-- 
Dr Alastair Brown
MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
Mailto:Alastair.Brown@hgu.mrc.ac.uk
http://www.hgu.mrc.ac.uk/Users/Alastair.Brown
Fax: +44 (0)131 343 2620    Phone: +44 (0)131 332 2471

From BIOSCI-REQUEST  Fri Apr 10 14:26:30 1998
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From: "Siamak Tabibzadeh, MD" <tabibzadeh@moffitt.usf.edu>
To: <mutation@net.bio.net>
Subject: Frontiers in Bioscience, A Journal and Virtual library
Date: Fri, 10 Apr 1998 17:22:38 -0400
MIME-Version: 1.0
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Frontiers in Bioscience

A Journal and Virtual library

THE BEST BIOSCIENCE HAS TO OFFER

Cited by MEDLINE, Index Medicus, BIOSIS and Chemical Abstracts

Frontiers in Bioscience (FBS) is a virtual journal and library bringing =
the most up-to-date data in life sciences and medicine to the desktop of =
every scientist. FBS offers distinct advantages over traditional print =
journals including a rapid review process, free world-wide access, =
electronic reprint, use of multimedia, and links to diverse databases =
including MEDLINE. FBS is read by over 75,000 readers internationally =
and is accessed over 200,000 times every month in the US alone. With its =
mirror sites, over 700 editors and nearly 100 managing editors, FBS is =
truly an international entity and a valuable platform for scientific =
communication. The virtual library provides numerous databases, valuable =
information as well as forms and links to thousands of Web sites of =
interest to researchers and physicians. Visit this scientific treasure =
on the Web.

Team up with distinguished scientists who contribute to FBS:




HIV-1 Nef and host cell protein kinases=20

Kalle Saksela=20

[Vol 2, pp d606-618. December 15, 1997] PubMed No: 9388166


Human immunodeficiency virus type I as a target for gene=20

therapy=20

Magn=FAs Gottfredsson and Paul R. Bohjanen=20

[Vol 2, pp d619-634, December 15, 1997] PubMed No: 9388165


Fibronectin-integrin interactions

S. Johansson, G. Svineng, K. Wennerberg, A. Armulik and L.=20

Lohikangas

[Vol 2 pp d126-146, March 1, 1997] PubMed No: 9159220




URLs:

USA: http://www.bioscience.org

Israel: http://bioinfo.weizmann.ac.il/bioscience

France: http://vega.crbm.cnrs-mop.fr/bioscience=20


Frontiers in Bioscience is a non-profit organization dedicated to =
fostering science, education and research


------=_NextPart_000_0004_01BD64A5.429849E0
Content-Type: text/html;
	charset="iso-8859-1"
Content-Transfer-Encoding: quoted-printable

<!DOCTYPE HTML PUBLIC "-//W3C//DTD W3 HTML//EN">
<HTML>
<HEAD>

<META content=3Dtext/html;charset=3Diso-8859-1 =
http-equiv=3DContent-Type>
<META content=3D'"MSHTML 4.72.2106.6"' name=3DGENERATOR>
</HEAD>
<BODY bgColor=3D#ffffff>
<DIV>
<DIV>
<DIV><FONT face=3D"Old English Text MT,Ribbon131 Bd BT" size=3D6>
<P align=3Dcenter>Frontiers in Bioscience</P>
<P align=3Dcenter>A Journal and Virtual library</P></FONT><B><FONT =
size=3D1>
<P align=3Dcenter>THE BEST BIOSCIENCE HAS TO OFFER</P></FONT><FONT =
size=3D1>
<P align=3Dcenter>Cited by MEDLINE, Index Medicus, BIOSIS and Chemical=20
Abstracts</P></B></FONT><FONT size=3D2></FONT><FONT size=3D1>
<P>Frontiers in Bioscience (FBS) is a virtual journal and library =
bringing the=20
most up-to-date data in life sciences and medicine to the desktop of =
every=20
scientist. FBS offers distinct advantages over traditional print =
journals=20
including a rapid review process, free world-wide access, electronic =
reprint,=20
use of multimedia, and links to diverse databases including MEDLINE. FBS =
is read=20
by over 75,000 readers internationally and is accessed over 200,000 =
times every=20
month in the US alone. With its mirror sites, over 700 editors and =
nearly 100=20
managing editors, FBS is truly an international entity and a valuable =
platform=20
for scientific communication. The virtual library provides numerous =
databases,=20
valuable information as well as forms and links to thousands of Web =
sites of=20
interest to researchers and physicians. Visit this scientific treasure =
on the=20
Web.</P>
<P align=3Djustify>Team up with distinguished scientists who contribute =
to=20
FBS:</P>
<P align=3Djustify>&nbsp;</P>
<P align=3Djustify></P></FONT><FONT size=3D1><B>
<P align=3Djustify>HIV-1 Nef and host cell protein kinases </P></B><I>
<P align=3Djustify>Kalle Saksela </P></I>
<P align=3Djustify>[Vol 2, pp d606-618. December 15, 1997] PubMed No: =
9388166</P>
<P align=3Djustify></P><B>
<P align=3Djustify>Human immunodeficiency virus type I as a target for =
gene </P>
<P align=3Djustify>therapy </P></B><I>
<P align=3Djustify>Magn&uacute;s Gottfredsson and Paul R. Bohjanen =
</P></I>
<P align=3Djustify>[Vol 2, pp d619-634, December 15, 1997] PubMed No: =
9388165</P>
<P align=3Djustify></P><B>
<P align=3Djustify>Fibronectin-integrin interactions</P></B><I>
<P align=3Djustify>S. Johansson, G. Svineng, K. Wennerberg, A. Armulik =
and L. </P>
<P align=3Djustify>Lohikangas</P></I>
<P align=3Djustify>[Vol 2 pp d126-146, March 1, 1997] PubMed No: =
9159220</P>
<P align=3Djustify></P></DIV><B>
<P>&nbsp;</P>
<P>URLs:</P></B>
<DIV>
<DIR>
<DIR><B>
<P>USA:</B> <I>http://www.bioscience.org</P></I><B>
<P>Israel: </B><I>http://bioinfo.weizmann.ac.il/bioscience</P></I><B>
<P>France:</B> http://<I>vega.crbm.cnrs-mop.fr/bioscience </P>
<P align=3Dcenter></P></DIR></DIR>
<P align=3Dcenter>Frontiers in Bioscience is a non-profit organization =
dedicated=20
to fostering science, education and=20
research</P></I></DIV></FONT></DIV></DIV></BODY></HTML>

------=_NextPart_000_0004_01BD64A5.429849E0--


From BIOSCI-REQUEST  Wed Apr 15 13:37:38 1998
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From: "Victor Graziano" <vic@acdlabs.com>
To: <btechniq@net.bio.net>, <cellbiol@net.bio.net>, <embl-db@net.bio.net>,
        <fluorpro@net.bio.net>, <genbankb@net.bio.net>, <glycosci@net.bio.net>,
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        "Protein Analysis Mailgroup" <protein-analysis@net.bio.net>,
        <staden@net.bio.net>, <tibs@net.bio.net>
Subject: Free Protein Manger Demo Software
Date: Wed, 15 Apr 1998 16:34:26 -0700
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Dear Colleague

	Advanced Chemistry Development Inc. (ACD), a leader in Cheminformatics
software, has just released Protein Manager, the newest member of its
extensive software family.  This remarkable software package, coupled wit=
h
the Swissprot, Prosite, PDB, ACD Restriction Enzyme and (soon to follow) =
ACD
Regulatory Protein Databases, will dramatically accelerate peptide drug
discovery.
	The primary functions of Protein Manager are protein analysis, data
management and data publishing.  Software operation is easy, simply load
candidate proteins into the Protein Manager 'protein workbook' and perfor=
m a
multitude of functions including:

-Isoelectric point determination
-Batch Phys-Chem property predictions
-Protein secondary structure prediction ( including Predator prediction
method)
-Multiple protein alignment with consensus matching
-Enzymatic digestion of selected proteins (ACD enzyme database)
-Protein scale determination (hydrophobicity, polarity, bulkiness...)
-3D viewing of all available Protein Database (PDB) files

	Furthermore, proteins may be generated at random in Protein Manager, or
modified from existing protein files.  It's as easy as cut, copy and
pasting.  Please feel free to visit our web site and download a demo copy=
 or
product video preview, both available March 31st and keep a lookout for G=
ene
Manager expected to ship in the Fall.  Should you have any questions
regarding Protein Manager, please feel free to contact one of our
sales representatives.

ACD thanks you for your time and hopes you enjoy Protein Manager.
_______________________________________

Victor Graziano B.Sc., M.Sc.
Advanced Chemistry Development, Inc.
Marketing & Sales Manager (Biochemistry)
T:=A0(416) 368-3435
F:=A0(416) 368-5596
US & Canada: (800) 304-3988
http://www.acdlabs.com


From BIOSCI-REQUEST  Thu Apr 16 00:11:46 1998
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Date: Thu, 16 Apr 1998 16:11:43 +0900 (JST)
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To: bioforum@net.bio.net, biomatrx@net.bio.net, celegans@net.bio.net,
        cellbiol@net.bio.net, chlamy@net.bio.net, biochrom@net.bio.net,
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From: lukacs@fly.erato.jst.go.jp (Tamas, Lukacsovich)
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Subject: looking for room mate for the FEBS
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Dear Anyone out there,

I am looking for somebody, who is going to participate in the FEBS meeting,
held in Denmark this summer, and would accept me as room mate to share the
expenses.
I am a non-smoking male but can tolerate even a smoker.

Tamas Lukacsovich


From BIOSCI-REQUEST  Fri Apr 17 06:44:37 1998
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Date: Fri, 17 Apr 1998 15:39:34 +0200
To: mutation@net.bio.net
From: Valeria Maida <naimi@ssmain.uniss.it>
Subject: NAIMI Congress
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<html>
<font face=3D"Garamond">It gives us great pleasure to inform you that the
NAIMI Congress will be held in Alghero, on the North West of Sardinia, in
the centre of Mediterranean Sea, this September as a satellite symposium
to the Congress in Coordination Chemistry in Florence. This congress is
specifically aimed at those working in the DNA Polymers field and
promises to be a valuable and stimulating occasion. The opportunity for
experts in the general chemical sector to meet those working on the base
of DNA and RNA in an informal setting should lead to interesting
brainstorming sessions, which will undoubtedly be of great use to both
sides.<br>
Yours,<br>
Prof. M.L.Ganadu=A0 &amp;=A0=A0 Prof. M. Taddei - Dipartimento di Chimica - =
via
Vienna, 2 - 07100 Sassari <br>
<br>
<br>
</font><font face=3D"Academy Engraved LET" size=3D1><b><div align=3D"center"=
>
UNIVERSIT=C0 DEGLI STUDI DI SASSARI<br>
</font></b><font face=3D"Demian Bold LET" size=3D7>NAIMI<br>
</font><font face=3D"Academy Engraved LET" size=3D3><i>Nucleic acids and
their interactions with metal ions<br>
<br>
<br>
</font></i><font face=3D"Garamond"><b>Satellite Symposium of the XXXIII
International Conference<br>
on Coordination Chemistry in Florence<br>
Alghero September 5-7 1998<br>
<br>
</b></div>
The mini symposium is intended for researchers in the Chemistry of
Nucleic Acids and Metal Ions field. The main objective of the symposium
is to bring together scientists interested in the different aspects of
the influence of metal ions on the structure and metabolism of DNA. The
main topics will be DNA Polymers, nucleic metal proteins, zinc fingers
and PNA.<br>
<br>
<b>Scientific Program:<br>
</b>The following distinguished speakers have already agreed to deliver a
lecture: <br>
Prof. James Allan Cowan (<i>COLUMBUS, USA</i>),=A0 <br>
Prof. Rob Kaptein (<i>UTRECHT, THE NETHERLANDS</i>),=A0=A0 <br>
Prof. Bernard Meunier (<i>CNRS, FRANCE</i>),=A0 <br>
Prof. Thomas W. Myers (<i>ROCHE, USA</i>),=A0=A0 <br>
Prof. Huguette Pelletier (<i>HOUSTON, USA</i>).=A0 <br>
Prof. Bibudgendra Sarkar (<i>TORONTO, CANADA</i>),=A0 <br>
In addition there will be a poster session and a number of selected oral
communications. All those who wish to participate are invited to submit
an abstract to the scientific committee.<br>
<br>
<b>Organising committee:<br>
</b>F. Bonomi (University of Milano - Italy) <br>
M.L. Ganadu, Chairperson (University of Sassari - Italy) <br>
H. Kozlowski (University of Wrocklaw - Poland) <br>
C. Mealli (CNR, Florence - Italy) <br>
A. Scozzafava (University of Florence - Italy) <br>
M. Taddei (University of Sassari - Italy) <br>
<br>
additional information and a registration form is available on:<br>
</font><font color=3D"#0000FF"><u><a=
 href=3D"http://www.uniss.it/web/congressi/naimi/naimiaw.htm"=
 eudora=3D"autourl">http://www.uniss.it/web/congressi/naimi/naimiaw.htm</a><=
br>
<br>
</font></u><font color=3D"#000000">For further information, please
contact:<br>
Peter Norton peter.norton@flashnet.it=A0=A0=A0=A0=A0=A0=A0=A0=A0 phone/fax:=
 +39 79
299640<br>
Naimi secretary naimi@ssmain.uniss.it=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=A0=
=A0 fax +39 79 229559 or
229482<br>
Newtours Evangelist@Mail.Newtours-CMO.it=A0=A0=A0=A0=
 Fax+3955/3361250/350<br>
<br>
</font>
<BR>
<div>*********************************************************************</=
div>
<div>Valeria
Maida<x-tab>&nbsp;&nbsp;&nbsp;</x-tab><x-tab>&nbsp;&nbsp;</x-tab><x-tab>&nbs=
p;</x-tab><x-tab>&nbsp;&nbsp;&nbsp;&nbsp;</x-tab>Tel.
+ 39 79 229542/229588&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </div>
<div>Dipartimento di
Chimica<x-tab>&nbsp;</x-tab><x-tab>&nbsp;&nbsp;&nbsp;&nbsp;</x-tab>fax&nbsp;
+ 39 79 229559/229482&nbsp;&nbsp;&nbsp;&nbsp; </div>
<div>via Vienna,
2<x-tab>&nbsp;&nbsp;&nbsp;</x-tab><x-tab>&nbsp;&nbsp;</x-tab><x-tab>&nbsp;</=
x-tab><x-tab>&nbsp;&nbsp;&nbsp;&nbsp;</x-tab>e-mail
billia@ssmain.uniss.it&nbsp;&nbsp;&nbsp; </div>
<div>07100
Sassari<x-tab>&nbsp;&nbsp;&nbsp;</x-tab><x-tab>&nbsp;&nbsp;</x-tab><x-tab>&n=
bsp;</x-tab><x-tab>&nbsp;&nbsp;&nbsp;&nbsp;</x-tab><x-tab>&nbsp;&nbsp;&nbsp;=
</x-tab><x-tab>&nbsp;&nbsp;</x-tab><x-tab>&nbsp;</x-tab><x-tab>&nbsp;&nbsp;&=
nbsp;&nbsp;</x-tab><x-tab>&nbsp;&nbsp;&nbsp;</x-tab><x-tab>&nbsp;&nbsp;</x-t=
ab><x-tab>&nbsp;</x-tab>&nbsp;&nbsp;&nbsp;
</div>
*********************************************************************
</html>

From BIOSCI-REQUEST  Thu Apr 23 17:31:25 1998
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Date: Fri, 24 Apr 1998 10:27:31 +1000
To: mutation@net.bio.net
From: Rania Horaitis <horaitis@ariel.ucs.unimelb.edu.au>
Subject: Mutation Database Meeting, Denver
Mime-Version: 1.0
Content-Type: text/plain; charset="us-ascii"

An application has been placed for a meeting on Mutation Databases adjacent
to the ASHG meeting this year.

October 27th

Denver, Colorado, USA

8am to 7pm

If you are interested, please put this in your diary.


Kind Regards,




Rania Horaitis
Co-Ordinator
HUGO Mutation Database Initiative
Mutation Research Centre
7th Floor, Daly Wing
St. Vincent's Hospital
41 Victoria Pde,
Fitzroy 3065
Australia

PH:	61-3-9288-2983
Fax:	61-3-9288-2988
Email:	horaitis@ariel.its.unimelb.edu.au

HUGO Mutation Database Initiative Website:
http://ariel.ucs.unimelb.edu.au:80/~cotton/mut_database.htm

From BIOSCI-REQUEST  Tue Apr 28 10:50:15 1998
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From: "Victor Graziano" <vic@acdlabs.com>
To: <vic@acdlabs.com>
Subject: Free ACD/Protein Manager Demo Software
Date: Tue, 28 Apr 1998 13:44:24 -0700
Message-ID: <000501bd72e6$6d988ac0$3ee9b0cf@vic.acdlabs.com>
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Dear Colleagues,

        Advanced Chemistry Development Inc. (ACD), a leader in
Cheminformatics software, has just released Protein Manager, the newest
member of its extensive software family.  This Bioinformatics software
package, coupled with the Swissprot, Prosite, PDB, ACD Restriction Enzyme
and (soon to follow)  ACD Regulatory Protein Databases, will dramatically
accelerate protein research and peptide drug discovery.

        ACD/Protein Manager is built around a three-in-one functionality
concept which  provides all the necessary features to Analyze, Publish (Web
& Desktop) and Manage protein sequence data.  Software operation is easy,
simply load candidate proteins into the Protein Manager 'protein workbook'
and perform a multitude of functions including:

-Isoelectric point determination
-Batch Phys-Chem property predictions
-Protein secondary structure prediction (including the newest Predator
prediction method)
-Multiple protein alignments with consensus matching
-Enzymatic digestion of selected proteins (utilizing ACD's enzyme database)
-Protein scale determination (hydrophobicity, polarity, bulkiness...)
-3D viewing of all available Protein Database (PDB) files

        More information outlining Protein Manager's functionality, along
with a short product video and future software releases (ACD Regulatory
Peptide DB or ACD/Gene Manager) are available at:

http://www.acdlabs.com/products/peptide/prot_mgr.html.

	Please feel free to contact myself or any of the other ACD representatives
for further information regarding Protein Manager or any of the other ACD
software titles.

Regards,

Victor Graziano B.Sc., M.Sc.
Advanced Chemistry Development, Inc.
Account Manager (Biochemistry)
T: (416) 368-3435
F: (416) 368-5596
US & Canada: (800) 304-3988
http://www.acdlabs.com


From BIOSCI-REQUEST  Tue Apr 28 20:17:10 1998
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Date: Tue, 28 Apr 1998 23:19:02 -0700
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IT WOULD BE KIND OF YOU,IF YOU COULD ASSIST ME WITH A DIAGRAM OF THE 
SUBJECT MATTER ABOVE.
      THANK YOU
          JOE

From BIOSCI-REQUEST  Wed Apr 29 03:56:03 1998
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From: Iain Fenton <Fenton@cardiff.ac.uk>
To: mutation@net.bio.net
Date:          Wed, 29 Apr 1998 11:43:41 GMT0BST
Subject:       p53 database at Mayo ?
Priority: normal
X-mailer: Pegasus Mail v3.22
Message-ID: <BB98C05597@wmg1.uwcm.ac.uk>

hi people,

the p53 mutation database at mayo seems to have gone missing, the 
link i have to it doesn't work and the (different) link from EBI is 
wrong as well.  searching at mayo gives me a server error, so i was 
wondering if anyone has an updated address for the site ?

it was "www.mayo.edu/papers/P53%20Mutations/" but this now gives me a 
permission error.

any ideas ?

Iain.

==================================================================
 Iain Fenton, Inst. of Medical Genetics, Univ. of Wales, Cardiff.

  "Traditional nationalism cannot survive the
   fissioning of the atom.  One world or none." - Stuart Chase
==================================================================

From BIOSCI-REQUEST  Wed Apr 29 06:53:47 1998
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From: "F. Abel Ponce de Leon" <apl@tc.umn.edu>
Reply-To: "apl@tc.umn.edu" <apl@tc.umn.edu>
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Date: Wed, 29 Apr 1998 08:51:55 -0500
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subscribe
-------------------------------------------------------
F. Abel Ponce de Leon            
Department of Animal Science
University of Minnesota
120 Peters Hall
1404 Gortner Av.
St. Paul, MN 55108

Tel: (612)624-2722; Fax: (612)625-5789
E-mail: apl@tc.umn.edu
-------------------------------------------------------


From BIOSCI-REQUEST  Wed Apr 29 17:01:03 1998
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	for <mutation@net.bio.net>; Thu, 30 Apr 1998 09:59:08 +1000 (AEST)
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Date: Thu, 30 Apr 1998 09:56:52 +1000
To: mutation@net.bio.net
From: Rania Horaitis <horaitis@ariel.ucs.unimelb.edu.au>
Subject: re p53 database
Mime-Version: 1.0
Content-Type: text/plain; charset="us-ascii"

Regarding the p53 database,

I too have found it has gone missing.

If anyone knows the address please announce it to the entire group.

Thank you.


Rania Horaitis
Co-Ordinator
HUGO Mutation Database Initiative
Mutation Research Centre
7th Floor, Daly Wing
St. Vincent's Hospital
41 Victoria Pde,
Fitzroy 3065
Australia

PH:	61-3-9288-2983
Fax:	61-3-9288-2988
Email:	horaitis@ariel.its.unimelb.edu.au

HUGO Mutation Database Initiative Website:
http://ariel.ucs.unimelb.edu.au:80/~cotton/mut_database.htm

From BIOSCI-REQUEST  Wed Apr 29 17:40:08 1998
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Date: Thu, 30 Apr 1998 10:36:00 +1000
To: mutation@net.bio.net
From: Rania Horaitis <horaitis@ariel.ucs.unimelb.edu.au>
Subject: HUGO-Mutation Detection Training Course
Cc: HUM-MOLGEN@NIC.SURFNET.NL, gnome-pr@net.bio.net
Mime-Version: 1.0
Content-Type: text/plain; charset="us-ascii"

This announcement will also be placed on the Mutation Database Website see
address below.

HUGO

Mutation Detection Training Course

4 - 7 September 1998
Hinxton Hall Conference Centre, Wellcome Trust Genome Campus, Cambridge, 
UK


Organiser: Graham Taylor (UK)        
E-mail:  gtaylor@hgmp.mrc.ac.uk

Advisors:  Richard G H Cotton (Australia),  Ulf Landegren (Sweden),
Mireille Claustres (France)
_____________________________________________________________________

This training course is a development of HUGO's highly successful
international Mutation Detection workshops.  Restricted to 50
participants, its aim is to provide a survey of currently available and
emerging technologies for mutation detection.  The course will be
suitable for post-graduate, medical and post-doctoral scientists whose
research and diagnostic interests could benefit from increased awareness 
of mutation detection techniques.  Lectures, given by leading
researchers in their fields, will give a background and overview of the
topics, describe the principles and applications and place the
techniques in context.  The lectures will be complemented by two
workshop demonstration sessions each day, which will give participants
hands-on experience with many of the techniques (see below for
details).  Participants are encouraged to bring some of their own work
for discussion during the course.


Duration:		4 days, arriving evening Thursday 3rd September, prior to Day 1

Course Fee:		#275 sterling (non-commercial participants);

 			#375 (commercial).

The course fee includes attendance at all sessions and also all coffee
breaks and lunches.

Accommodation:       On-site accommodation will be available at a cost of
#30 per person (or #20 room sharing) per night, including breakfast.
Accommodation will be required for either 4 or 5 nights, depending on your
travel arrangements.	


Demand for this course is expected to rapidly exceed the 50 places
available.  If this is so, participants will be selected on a 'one person
per lab' basis to ensure that as many labs as possible can benefit from the
training.  If you are interested in attending, you should therefore
register you interest as soon as possible by sending a fax or E-mail to the
HUGO office in London:

HUGO, 
One Park Square West, 
London NW1 4LJ, UK

Tel: [44] (171) 935 8085	        Fax: [44] (171) 935 8341
Email:  hugo@hugo-europe.org.uk


WORKSHOP PROGRAMME

Day 1. Friday 4th September:	Mutation Testing (assays for specific
mutations)
____________________________________________________________________________
___

08:45 - 08:55	Brief introduction; course overview.   Dr Graham Taylor
(St James's University Hospital, Leeds, UK)

09:00 - 09:45	Overview of which kinds of mutations to screen for and
which techniques to use. Prof Mireille Claustres (CNRS, Montpellier,
France)

09:45 -10:30	Testing for specific mutations. Dr Rich Ferrie (Zeneca)

10:30 - 11:00	Coffee

11:00 - 12:30	WORKSHOP DEMONSTRATIONS
ARMSTM (Amplification Refractory Mutation System);  Dot blot
hybridisation; Taqman;  OLA (Oligonucleotide Ligation Assay); FMR1
expansion;  Molecular Beacons

12:30 - 13:30	Lunch

13:30 - 14:15	High throughput systems.  Professor Ian Day (University
of Southampton, UK)

14:15 - 15:00	Population studies: examples of mutation screening
programmes.  Dr Marianne Schwarz (Rigshospitalet, Copenhagen)

15:00 - 15:30	Tea

15:30 - 17:30	WORKSHOP DEMONSTRATIONS
MADGE (Microplate Array Diagonal Gel Electrophoresis); DHPLC (Denaturing 
High Pressure Liquid Chromatography); DNA and RNA extraction methods;
high throughput DNA extraction


Day 2. Saturday 5th September:  Mutation Scanning (assays for any
mutation)
____________________________________________________________________________
______

09:00 - 09:30	SSCP/HA   Dr  Margaret Galvin (AxyS Pharmaceuticals)

09:30 - 10:00	DGGE (Denaturing Gradient Gel Electrophoresis).  Dr
Milan Macek Jr (Prague University Hospital, Czech Republic)

10:00 - 10:30	RNAase cleavage.     Dr Marianna Goldrick (Ambion)

10:30 - 11:00	Coffee

11:00 - 12:30	WORKSHOP DEMONSTRATIONS
	SSCP (Single Stranded Conformational Polymorphism); DGGE
(Denaturing Gradient Gel Electrophoresis);  RNase cleavage

12:30 - 13:30	Lunch

13:30 - 14:15	Protein truncation.     Dr Sylvie Tuffery (CNRS,
Montpellier, France)

14:15 - 15:00	Chemical cleavage of mismatch.   Dr Mario Tosi (Pasteur
Institute, Paris, France)

15:00 - 15:45	Enzymatic methods for mutation detection.  Dr Mats
Inganas (Amersham-Pharmacia)

15:30 - 16:00	Tea

16:00 - 17:30	WORKSHOP DEMONSTRATIONS
PTT (Protein Truncation Test);  CCM (Chemical Cleavage of Mismatch);
EMC (Enzyme Mismatch Cleavage)


Day 3. Sunday 6th September:  Sequencing and Emerging Technologies
____________________________________________________________________________
______

09:00 - 09:45	Applications of large scale mutation analysis in gene
discovery.  Speaker to be announced

09:45 - 10:30	Sequencing by hybridisation.  Professor Ed Southern
(University of Oxford, UK)

10:30 - 11:00	Coffee

11:00 - 12:30	WORKSHOP DEMONSTRATIONS
BiomekTM workstation (Beckman Instruments, USA);  PE-AB 877 (Perkin
Elmer - Applied Biosystems);  SBH (Sequencing by Hybridisation): PCR and 
sequencing robotics (MWG Biotech)

12:30 - 13:30	Lunch

13:30 - 14:15	Heterozygote sequencing.   Speaker to be announced

14:15 - 15:00	Gene chip analysis.  Dr JianBing Fan (Affymetrix)

15:00 - 15:30	Tea

15:30 - 17:30	WORKSHOP DEMONSTRATIONS
Sequence analysis software; From sequence to phenotype: Managing
sequence and mutation data


Day 4. Monday 7th September:  Handling Mutation Data
____________________________________________________________________________
______

09:00 - 09:45	Frequency and nature of mutations. Mutation
nomenclature.   Speaker to be announced

09:45 - 10:30	Sequence analysis software.   Speaker to be announced

10:30 - 11:00	Coffee

11:00 - 12:30	WORKSHOP on Mutation databases and gene databases
Dr Heikki Lehvaslaiho (European Bioinformatics Institute, Hinxton,
Cambridge, UK)

12:30 - 13:30	Lunch

13:30 - 14:15	Quality control in mutation detection.  
Professor Jean-Jacques Cassiman (University of Louvain, Belgium)

14:15 - 15:00	Future developments and applications.  Professor Ulf
Landegren (Uppsala Biomedical Centre, Sweden)

15:00 - 15:30	Tea

15:30 - 17:30	Poster discussion.  General discussion.


COURSE ENDS



From BIOSCI-REQUEST  Wed Apr 29 20:05:03 1998
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Date: Wed, 29 Apr 1998 20:04:18 -0700
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From: Dr.Allen@mailexite.com
To: Medical, Professionals
Subject:  Free Allergy Screening!
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//////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
You can now add allergy screening and custom immunotherapy to your practice-
and there are no upfront costs.

Benefits include continuity of care for the patient, excellent desensitization
programming, and significantly increased revenues for your practice.

Complete program includes training, laboratory based allergy screening, and
complete immunotherapy program in injection ready format.  See how "Allergy
Treatment is Made Easy" through the BioSafe, "Is Life Making You Sick" allergy
treatment program.

Register for your free allergy screening kits and complete information
package:

http://www.freeyellow.com/members3/algree



From BIOSCI-REQUEST  Wed Apr 29 20:04:38 1998
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Date: Wed, 29 Apr 1998 20:04:18 -0700
Message-Id: <199804300304.UAA13512@net.bio.net>
From: Dr.Allen@mailexite.com
To: Medical, Professionals
Subject:  Free Allergy Screening!
X-Reply-To:  www.freeyellow.com/members3/algree
Content-Type: text/plain; charset=ISO-8859-1
Content-Transfer-Encoding: 7bit

//////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
You can now add allergy screening and custom immunotherapy to your practice-
and there are no upfront costs.

Benefits include continuity of care for the patient, excellent desensitization
programming, and significantly increased revenues for your practice.

Complete program includes training, laboratory based allergy screening, and
complete immunotherapy program in injection ready format.  See how "Allergy
Treatment is Made Easy" through the BioSafe, "Is Life Making You Sick" allergy
treatment program.

Register for your free allergy screening kits and complete information
package:

http://www.freeyellow.com/members3/algree