From owner-recombination@net.bio.net Sat Mar 01 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: Inbreeding in South America Date: 1 Mar 1997 20:34:41 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 31 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar1.233426-0500_est.471259-22758+4156@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net ---------- From: Daniel Trbovich To: bionet-genome-gene-structure@net.bio.net Subject: Inbreeding in South America Date: Sunday, February 23, 1997 8:50 PM Everyone et. al. If this posting turns up somewhere irrelevant, I apologise in advance. I'm doing some research in genetic inbreeding. These being geneticist lists, I thought I'd give this a try. I am trying to locate references and sources on inbreeding in the German colonies of either Brazil, Paraguay or Argentina. Apparently, there are areas in these Latin American countries which have areas highly populated by Germans and their decendents. These societies have developed a narrow-minded attitude and refuse to have any interaction with outsiders to the extent that inbreeding amoung the population has occured. This has resulted from viewing other locals in the area as "inferior".I know this exists because a program was done on this some years back by a group of researchers. I haven't been able to find anything on them though. I can't remember who it was that did the study, all I remember was that at the time, the situation was reaching a critical level and that something had to be done. Maybe, (but I'm not sure) the words "Nueva Bavaria" or "Colonia Indepencia" or "Parana River" might ring a bell for someone. I think this is the areas under question, but maybe not. Any assistance in this matter would be greatly appreciated and I thank you in advance for your help. Thank you DDT From owner-recombination@net.bio.net Sat Mar 01 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET (Graham Dellaire) Newsgroups: bionet.molbio.recombination Subject: New on Exp. Med. Job Listings (Junior Scientist in Montreal, IRCM) Date: 2 Mar 1997 11:47:19 -0800 Organization: McGill Div. of Experimental Medicine Lines: 76 Sender: daemon@net.bio.net Distribution: world Message-ID: <3319D80E.4722@odyssee.net> Reply-To: dellaire@odyssee.net NNTP-Posting-Host: net.bio.net *****DO NOT REPLY TO THIS LISTING DIRECTLY PLEASE GO USE THE WEB SITE ADDRESS LISTED BELOW. ALL E-MAIL RECIEVED BY THIS ADDRESS WILL BE DELETED WITHOUT COMMENT***** To apply to this listing and to find more information please set your browser to: http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html go to "Positions"/ "Montreal Area" / "IRCM" The following is a description of one of several jobs offered from our site. NEW FROM EXPMED JOB LISTINGS!!! JUNIOR RESEARCH SCIENTIST Postition (Developmental biology / pituitary gene expression / hormone action)=20 Project description:=20 The Laboratory of Molecular Genetics at the IRCM is recruiting a junior research scientist to join a group active in the field of pituitary gene expression, pit uitary differentiation and development, and the mechanism of nuclear receptor ac tion. The successful candidate has a background in developmental biology, in mo lecular biology or in endocrine research. He will develop an independent resear ch program in an area related to those of the Laboratory. The candidate will ho ld academic appointment and be expected to obtain research grants. In addition, it is hoped that he will participate in projects of the laboratory on the contr ol of POMC gene expression either by developmentally regulated factors or in res ponse to hormonal signals (e.g. Lamonerie et al, Gene Dev 1996, 10:1284-1295).=20 Deadline: NOT SET. Screening of applicants will begin immediately.=20 fran=E7ais Biologie du d=E9veloppement / expression des g=E8nes hypophysaires / acti= on hormonale=20 Le laboratoire de G=E9n=E9tique mol=E9culaire de l'IRCM recrute un cherch= eur junior po ur joindre un groupe actif dans les domaines de l'expression g=E9n=E9tique dans l'hy pophyse, de la diff=E9renciation et du d=E9veloppement des structures hypophysaires et cr=E2niennes, et dans les m=E9canismes de l'action des r=E9cepteurs nucl=E9aires. Le candidat recherch=E9 poss=E8de une formation pr=E9alable soit en biologie du d=E9velopp ement, en biologie mol=E9culai= re ou en recherche en endocrinologie. Il d=E9velopper a un programme de recherche ind=E9pendant dans un domaine apparent=E9 =E0 celu= i du Lab oratoire. Le candidat aura un poste acad=E9mique et il est attendu qu'il puisse o btenir des subventions de recherche. De plus, il est esp=E9r=E9 que le candidat par ticipera aux projets du laboratoire sur le contr=F4le de l'expression du g=E8ne de l a POMC, soit en r=E9ponse =E0 des facteurs d=E9veloppementaux ou =E0 des signaux hormona ux (par exemple, Lamonerie = et al, Gene Dev 1996, 10:1284-1295).=20 Deadline: NOT SET. Screening of applicants will begin immediately.=20 Publications:=20 1.Lamonerie et al, Gene Dev 1996, 10:1284-1295 Qualifications:=20 Ph.D. in Biochemistry/Molecular Biology or related field. The candidate will hold academic appointment and be expected to obtain research grants. From owner-recombination@net.bio.net Mon Mar 10 22:00:00 1997 Path: biosci!ihnp4.ucsd.edu!swrinde!howland.erols.net!cam-news-hub1.bbnplanet.com!news.bbnplanet.com!news.maxwell.syr.edu!europa.clark.net!news.clark.net!kcowing-ppp.clark.net!user From: genomics@aibs.org (AIBS) Newsgroups: bionet.molbio.recombination Subject: Genomics: A Global Resource is now online Date: Tue, 11 Mar 1997 13:12:29 -0500 Organization: American Institute of Biological Sciences Lines: 54 Message-ID: NNTP-Posting-Host: kcowing-ppp.clark.net Mime-Version: 1.0 Content-Type: TEXT/PLAIN; charset=ISO-8859-1 Content-Transfer-Encoding: 8bit FOR IMMEDIATE RELEASE March 10, 1997 Contact: Jeff Trewhitt (202) 835-3469 PhRMA, AIBS SEEK TO PROVIDE UP-TO-DATE INTERNET INFORMATION ON GENOMICS http://www.phrma.org/genomics Washington, D.C. -- The Pharmecutical Research and Manufacturers of America (PhRMA) and the American Institute of Biological Sciences (AIBS) have introduced an Internet web site on genomics to provide up-to-date information on emerging genetic research-related issues. "The goal is to add useful information on genomics as it becomes available, and to list other sources of pertinent material from around the world," says Dr. Gillian R. Woollett, the web site publisher and PhRMA's Assistant Vice President for Biologics and Biotechnology. "We want to provide a dynamic and accessible information resource for policy makers and the general public." The new site, "Genomics - A Global Resource," provides information on gene therapies and genetic sampling, testing and screening. It also provides data on the genetics of biodiversity and protecting endangered species. The site, http://www.phrma.org/genomics, is also listed on the first page of both PhRMA's and AIBS's Internet web sites. In addition to Woollett, genomics web site coordinators include Keith L. Cowing and J. Richard Keefe, both of AIBS. AIBS is a not-for-profit association of academic societies, institutes and museums interested in the biological sciences. It is dedicated to promoting sound science in education, research and public policy. PhRMA's web site also contains a variety of documents on the research-based pharmaceutical industry, including an Industry Profile, press releases, policy statements, PhRMA's Medicines in Development survey series and Health Guides. The Pharmaceutical Research and Manufacturers of America (PhRMA) represents the country's leading research-based pharmaceutical and biotechnology companies, which are devoted to inventing medicines that allow patients to lead longer, happier, healthier and more productive lives. Investing nearly $19 billion a year in discovering and developing new medicines, PhRMA companies are leading the way in the search for cures. # # # Genomics Internet Address: http://www.phrma.org/genomics PhRMA Internet Address: http://www.phrma.org/ AIBS Internet Address: http://www.aibs.org From owner-recombination@net.bio.net Thu Mar 13 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET (Graham Dellaire) Newsgroups: bionet.molbio.recombination Subject: NEW ON THE EXP MED JOB LISTING (POST DOC IN FRANCE: PRIONS and ENCEPHALITIS) Date: 13 Mar 1997 16:16:01 -0800 Organization: McGill Div. of Experimental Medicine Lines: 84 Sender: daemon@net.bio.net Distribution: world Message-ID: <3328974D.5641@odyssee.net> Reply-To: dellaire@odyssee.net NNTP-Posting-Host: net.bio.net DO NOT REPLY DIRECTLY VIA YOUR NEWS READER!!! TO APPLY TO THIS JOB AND OTHERS LIKE IT PLEASE SEE THE EXPMED JOB LISTING at: http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html#EURO ALL INFORMATION ON HOW TO APPLY TO THIS POST IS FOUND AT THIS SITE. ***REPLIES VIA E_MAIL TO THIS BIONET POST (i.e. directly to dellaire@odyssee.net) WILL BE DELETED WITHOUT COMMENT**** =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D NEW ON EXP MED JOB LISTINGS Post-doc in France: ROLE OF THE PRION PROTEIN IN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES ROLE DE LA PROTEINE DU PRION DANS LES ENCEPHALOPATHIES SPONGIFORMES TRANSMISSIBLES=20 =20 Sylvain Lehmann=20 Washington University School of Medicine,=20 St Louis, MO, USA=20 Project description:=20 - Specific subject: Normal and Pathogenic function of the prion protein=20 Research areas for the fellowship may be: 1- Role of the prion protein in cell adhesion and at the synapse. Several transfected cell lines expressing wild-type and mutated prion proteins will be available to start this project.=20 2- Processing of the prion protein (cleavage, degradation=85) in cell culture and in tissues. Development of immunological tools to detect prion protein fragments.=20 3- Creation of new cell culture models of infectious forms of transmissible spongiform encephalopathies=20 In France, post doctoral fellowships have to be jointly applied by the candidate and the laboratory. Therefore, this offer aims, in the first place, to write an application for a post doctoral fellowship. I have just spend 4 years in the States (see below) and I will start my own group in Montpellier (France) to work on prion diseases. If you are interested, we can apply together for a fellowship.=20 - Theme propose: Etude de la fonction normale et pathologique de la proteine du Prion. Les differents domaines de recherche sur lesquels la demande peut etre faite sont: 1- L'Etude du role physiologique de la proteine du prion, en particulier dans les mecanismes d'adhesion et de reconaissance intercellulaire et au niveau synaptique. Differentes lignees cellulaire qui expriment des proteines du prion sauvage et mutees sont disponibles pour debuter ce projet.=20 2- Etude du clivage proteolytique de la proteine du prion et plus generalement de son metabolisme. Etudes qui pourront etre realisees en culture cellulaire mais egalement a partir de tissus. Mise au point de techniques immunologiques de detection des differents fragments de la proteine du prion.=20 3- Mise au point de nouveaux modeles en culture cellulaire des formes infectieuses des encephalopathies spongiformes transmissibles=20 En France, il est necessaire d'avoir un candidat et un laboratoire pour postuler a une bourse post-doctorale. Cette proposition a pour but, en premier lieu, d'etablir un dossier de demande de bourse pour rejoindre mon laboratoire. Je viens de passer 4 ans aux USA a travailler sur la proteine du prion (voir ci-dessous) et je vais m'installer a Montpellier a la rentree 1997. Si vous etes interesse(e), nous pouvons postuler ensemble a une bourse From owner-recombination@net.bio.net Thu Mar 13 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: NEW ON THE EXP MED JOB LISTING (POST DOC IN FRANCE: PRIONS and ENCEPHALITIS) Date: 13 Mar 1997 16:25:36 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 117 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar13.192543-0500_est.471177-181+3670@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net DO NOT REPLY DIRECTLY VIA YOUR NEWS READER!!! TO APPLY TO THIS JOB AND OTHERS LIKE IT PLEASE SEE THE EXPMED JOB LISTING at: http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html#EURO ALL INFORMATION ON HOW TO APPLY TO THIS POST IS FOUND AT THIS SITE. ***REPLIES VIA E_MAIL TO THIS BIONET POST (i.e. directly to dellaire@odyssee.net) WILL BE DELETED WITHOUT COMMENT**** =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D NEW ON EXP MED JOB LISTINGS Post-doc in France: ROLE OF THE PRION PROTEIN IN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES ROLE DE LA PROTEINE DU PRION DANS LES ENCEPHALOPATHIES SPONGIFORMES TRANSMISSIBLES=20 =20 Sylvain Lehmann=20 Washington University School of Medicine,=20 St Louis, MO, USA=20 Project description:=20 - Specific subject: Normal and Pathogenic function of the prion protein= =20 Research areas for the fellowship may be: 1- Role of the prion protein in cell adhesion and at the synapse. Several transfected cell lines expressing wild-type and mutated prion proteins will be available to start this project.=20 2- Processing of the prion protein (cleavage, degradation=85) in cell culture and in tissues. Development of immunological tools to detect prion protein fragments.=20 3- Creation of new cell culture models of infectious forms of transmissible spongiform encephalopathies=20 In France, post doctoral fellowships have to be jointly applied by the candidate and the laboratory. Therefore, this offer aims, in the first place, to write an application for a post doctoral fellowship. I have just spend 4 years in the States (see below) and I will start my own group in Montpellier (France) to work on prion diseases. If you are interested, we can apply together for a fellowship.=20 - Theme propose: Etude de la fonction normale et pathologique de la proteine du Prion. Les differents domaines de recherche sur lesquels la demande peut etre faite sont: 1- L'Etude du role physiologique de la proteine du prion, en particulie= r dans les mecanismes d'adhesion et de reconaissance intercellulaire et au niveau synaptique. Differentes lignees cellulaire qui expriment des proteines du prion sauvage et mutees sont disponibles pour debuter ce projet.=20 2- Etude du clivage proteolytique de la proteine du prion et plus generalement de son metabolisme. Etudes qui pourront etre realisees en culture cellulaire mais egalement a partir de tissus. Mise au point de techniques immunologiques de detection des differents fragments de la proteine du prion.=20 3- Mise au point de nouveaux modeles en culture cellulaire des formes infectieuses des encephalopathies spongiformes transmissibles=20 En France, il est necessaire d'avoir un candidat et un laboratoire pour postuler a une bourse post-doctorale. Cette proposition a pour but, en premier lieu, d'etablir un dossier de demande de bourse pour rejoindre mon laboratoire. Je viens de passer 4 ans aux USA a travailler sur la proteine du prion (voir ci-dessous) et je vais m'installer a Montpellier a la rentree 1997. Si vous etes interesse(e), nous pouvons postuler ensemble a une bourse =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D | Graham Dellaire =20 | =20 | Division of Experimental Medicine =20 | Dept of Medicine, McGill University |(http://www.medcor.mcgill.ca/EXPMED/DOCS/expmed.html) = =20 =20 |=20 | e-mail: dellaire@odyssee.net =20 | Fax: (514) 896 4689 =20 | Vox: (514) 281 6000 ext. 6936 |=20 | Bionet: bionet.molbio.recombination | bionet.genome.gene-structure =20 =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D | Snail Mail: =20 | Institut du Cancer de Montreal =20 | Centre de Recherch L.C. Simard =20 | 1560 Sherbrooke St. East =20 | Montreal, Quebec, CANADA =20 | H2L 4M1 =20 =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D From owner-recombination@net.bio.net Fri Mar 14 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: POSTDOCTORAL FELLOW POSITION, DNA REPLICATION(Dr. Carl Schildkraut) Date: 15 Mar 1997 15:44:25 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 40 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar15.184516-0500_est.731586-165+1006@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net POSTDOCTORAL FELLOW POSITION AVAILABLE A position is available to study the molecular genetics of replication and the cell cycle in the mammalian genome. We use Epstein-Barr and human papilloma virus sequences as model systems both in vivo and in vitro to study site-specific initiation and termination of DNA replication (Cell 58:527, 1989; Mol. Cell. Biol. 11:6268, 1991; J. Virol. 67:1739, 1993; Mol. Cell. Biol. 15:2893, 1995; J. Biol. Chem. 271:33009, 1996). The replication of globin and immunoglobulin gene families (Mol. Cell. Biol. 8: 2149 and 4958, 1988; 9:3524, 1989; 10:4314 and 4324, 1990) and the role of replication in oncogene rearrangements and in development is being investigated. We are characterizing origins of replication that we have identified in human rDNA (Mol. Cell. Biol., 13:6600, 1993). Targeted integration mediated by homologous recombination will be used to modify chromosomal origins and to determine the sequences critical for origin function. Other projects include the role of the Locus Control Region (LCR) in the regulation of replication of globin and immunoglobulin gene loci. The spatial and temporal organization of DNA replication in mammalian nuclei is also being studied. Supported by NIH funding for at least three years. The Albert Einstein College of Medicine is located in a pleasant, very safe, residential area of New York. Send curriculum vitae by both Email and FAX or Air Mail and the names of three references (including telephone, FAX and Email numbers) to: Dr. Carl Schildkraut Department of Cell Biology (CH 416) Albert Einstein College of Medicine 1300 Morris Park Ave. New York, New York 10461 Phone (718) 430-2097 FAX (718) 430-8574 Email schildkr@aecom.yu.edu From owner-recombination@net.bio.net Fri Mar 14 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: New on ExpMed Job Listings (Post Doc: fluorescence polarization assays (FPA) for the diagnosis of infectious disease) Date: 15 Mar 1997 11:17:09 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 83 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar15.141746-0500_est.535062-165+836@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net DO NOT REPLY TO THIS MESSAGE DIRECTLY PLEASE VISIT http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html New on ExpMed Job Listings (Post Doc: fluorescence polarization assays (FPA) for the diagnosis of Infectious Disease Min Lin, Ph.D. Animal Diseases Research Institute Immunology Nepean, Ontario, Canada Project description: A post-doctoral position is available immediately to carry out research that leads to development of homogeneous fluorescence polarization assays (FPA) for the diagnosis of infectious diseases. The studies may include identification and characterization of the immunodominant protein/carbohydrate antigens from pathogenic bacteria, molecular cloning, protein expression/purification, epitope mapping, chemical modification of proteins, structure/function analysis of proteins, and assessment of the immune response to antigens. Recent publications: (1)Lin, M., and K. Nielsen. 1997. Binding of the Brucella abortus lipopolysaccharide O-chain fragment to a monoclonal antibody. J. Biol. Chem. 272:2821-2827. (2) Lin, M., E. A. Sugden, et al. 1996. Modification of the Mycobacterium bovis extracellular protein MPB70 with fluorescein for rapid detection of specific serum antibodies by fluorescence polarization. Clin. Diagn. Lab. Immunol. 3:438-443. Positions: 1 Post Doctoral position Qualifications: Applicants should possess a recent Ph.D. degree in Biochemistry, Microbiology or related field with experience in protein and molecular biology. To Apply: See Positions/Ontario from the web page http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html#ONT ===================================== | Graham Dellaire | | Division of Experimental Medicine | Dept of Medicine, McGill University |(http://www.medcor.mcgill.ca/EXPMED/DOCS/expmed.html) | | e-mail: dellaire@odyssee.net | Fax: (514) 896 4689 | Vox: (514) 281 6000 ext. 6936 | | Bionet: bionet.molbio.recombination | bionet.genome.gene-structure ===================================== | Snail Mail: | Institut du Cancer de Montreal | Centre de Recherch L.C. Simard | 1560 Sherbrooke St. East | Montreal, Quebec, CANADA | H2L 4M1 ===================================== From owner-recombination@net.bio.net Fri Mar 14 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: POSTDOCTORAL Position : DNA Replication Date: 15 Mar 1997 15:44:22 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 31 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar15.184516-0500_est.731578-174+1011@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net A postdoctoral position funded by an NIH grant is available in my laboratory at the Roswell Park Cancer Institute in Buffalo, New York. I am looking for a Ph.D. scientist with strong laboratory skills in molecular biology. My laboratory is investigating DNA replication origins with respect to the genetic components and the molecular mechanisms that regulate their activity. We are interested in how DNA replication origins are specified and activated within cellular chromosomes. We are currently focused on DNA replication origins in chromosomes of the yeast, S. cerevisiae. Yeast offers advantages of being highly amenable to genetic manipulation and analysis. These advantages have been further enhanced by the recent determination of the entire DNA sequence of the yeast genome. Additional information about research in my laboratory can be found at the following address on the World Wide Web: http://mcbio.med.buffalo.edu/dk.htm Applicants should send me (preferably via E-mail or FAX) a copy of their CV along with the names and addresses of three references. Send the information to: E-mail: kowalski@sc3101.med.buffalo.edu FAX: 716-845-8169 David Kowalski Molecular & Cellular Biology Dept. Roswell Park Cancer Institute Buffalo, New York 14263 USA From owner-recombination@net.bio.net Fri Mar 14 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: Post-Doctoral Position Offered In Gene Therapy Date: 15 Mar 1997 15:40:09 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 60 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar15.184054-0500_est.731479-173+1004@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net html version: http://wwwcjp.u-clermont1.fr/news/cjp970130.html ------------------------------------------------------- POST-DOCTORAL POSITION OFFERED IN GENE THERAPY AT CENTRE JEAN PERRIN AREA OF RESEARCH Ovarian cancer with a syngenic model in rat (collaboration with Th. Hamilton. Philadelphia, PA, USA). Gene therapy with different genes : BRCA1, gIFN, IL12, HSV-TK, B7.1, more or less combined with conventional therapy like indomethacine ? Vectors : retrovirus (LXSN), chemical (DOTAP and derivatives). Target cells : tumor cells, fibroblasts PRESENTATION OF THE LABORATORY INSERM team involved in the genetics of hereditary predisposition to breast/ovarian cancer since 1992. About 700 families are registered and a specialized oncogenetics consultation works in the same unit. French coordinator of BRCA1 and BRCA2 familial diagnoses. First french group involved in oncogenetics. Gene therapy is a new item in the group since late 1995 : 5 studients work in this field. The lab is inside the regional anticancer center, tightly linked to the medical team, completly equiped for gene therapy with in particular a high security lab (P3 type). POSITION PROPOSED 15 000 FF per month (a bit less than US$ 3 000) for 18 months, with 3 months testing the candidate before contract for 15 more months financed by a private company possibility for a definitive employement. starting in February or July 1997 CONTACT Pr Yves-Jean BIGNON Mail address : Pr Yves-Jean BIGNON Centre Jean Perrin 58, Rue Montalembert B.P. 392 63011 Clermont-Ferrand Cedex 01 Phone : +33 (0)473 27 80 50 Fax : +33 (0)473 26 34 51 E-Mail : Yves-Jean.Bignon@cjp.u-clermont1.fr web web From owner-recombination@net.bio.net Fri Mar 14 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: Post Doctoral positions in DNA recombination and replication Murty Madiraju Date: 15 Mar 1997 15:36:06 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 33 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar15.183656-0500_est.731411-165+1001@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net Post doctoral positions available immediately to investigate: (1) DNA gap repair (Recombinational repair) and the role of RecF and its associated proteins; (2) DNA replication initiation mechanisms in mycobacteria. DNA gap repair: In this project the role of E. coli RecF, RecO, RecR and Ssb proteins in the RecA protein catalyzed daughter strand gap repair will be investigated. Both biochemical and genetic approaches will be used to investigate protein-protein and protein-DNA interactions and the effects of nucleotides on these interactions will be investigated. Research experience in DNA binding protein characterization and bacterial genetics is desirable. DNA replication initiation mechanisms: In this project events involved in the replication initiation process in Mycobacterium tuberculosis, the causative agent of tuberculosis [doubling time is 22- 24 hours] and M. avium, the opportunistic pathogen of AIDS patients [doubling time 10- 12 hours] and M. smegmatis, a nonpathogen and rapid grower [doubling time 2-3 hours] will be investigated. Both Molecular biological and genetic techniques will be employed. Research experience either in DNA replication and or mycobacteriology is required. The biomedical research center in Tyler is actively growing and the city of Tyler is a pleasant place to live. Interested candidates please submit a cover letter explaining the research area of interest, curriculum vitae and three references as early as possibly. contact address: Dr. Murty Madiraju, Department of Microbiology, the University of Texas Health Center, Tyler, TX-75710; Ph. 903-877-2877; Fax: 903-877-7652 and e.mail: murty@uthct.edu From owner-recombination@net.bio.net Sat Mar 15 22:00:00 1997 Path: biosci!bdg10.niddk.nih.gov!KAYUWEW From: KAYUWEW@bdg10.niddk.nih.gov ("WAGNER, KAY-UWE") Newsgroups: bionet.molbio.recombination Subject: Flp-frt system Date: 15 Mar 1997 18:32:08 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 6 Sender: daemon@net.bio.net Distribution: world Message-ID: NNTP-Posting-Host: net.bio.net Hi, has anybody an idea whether or not the Flp-frt recombination system is patented? Kay kayuwew@bdg10.niddk.nih.gov From owner-recombination@net.bio.net Sat Mar 15 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: Re: Flp-frt system Date: 15 Mar 1997 21:20:57 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 94 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar16.002139-0500_est.479250-165+1225@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net Hello Kay, You can search the US. Patents from this web site... can be time consuming so I did a quick search in 96-97 and 95 but you may want to go farther. It is my guess that too much was published at first and now it is a dead duck. Not patentable. You lose the right to an international patent as soon as you publish and then you have 1 year for a Canadian or U.S. patent. After the year it is too late... it is forever public domain. The site is at:http://patents.cnidr.org/access/search-bool.html If their is a patent it is probably held by Dr. Paul Sadowski at U of Toronto. He is one of the first guys to work on FLP. Cheers, Graham Dellaire RECOM P.S. This is what I found. United States Patent 5,527,695 Hodges, et. al. Jun. 18, 1996 Controlled modification of eukaryotic genomes Inventors: Hodges; Thomas K. (West Lafayette, IN); Lyznik; Leszek A. (West Lafayette, IN). Assignee: Purdue Research Foundation (West Lafayette, IN). Appl. No.: 010,997 Filed: Jan. 29, 1993 ---------------- Process for predicting the phenotypic trait of yield in maize Inventors: Johnson; Richard (Urbana, IL). Assignee: DeKalb Genetics Corp. (DeKalb, IL). Appl. No.: 121,391 Filed: Sept. 14, 1993 Intl. Cl. : A01H 1/00, C12N 15/00 U.S. Cl.: 47/58; 435/172.3; 800/DIG.56 Current U.S. Class: 47/58 Field of Search: 435/172.3, 172.1, 6; 935/76; 47/58.05, 58.03 References Cited | [Referenced By:] ===================================== | Graham Dellaire | | Division of Experimental Medicine | Dept of Medicine, McGill University |(http://www.medcor.mcgill.ca/EXPMED/expmed.html) | | e-mail: dellaire@odyssee.net | Fax: (514) 896 4689 | Vox: (514) 281 6000 ext. 6936 | | Bionet: bionet.molbio.recombination | bionet.genome.gene-structure ===================================== | Snail Mail: | Institut du Cancer de Montreal | Centre de Recherch L.C. Simard | 1560 Sherbrooke St. East | Montreal, Quebec, CANADA | H2L 4M1 ===================================== From owner-recombination@net.bio.net Sat Mar 15 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: ***TO ALL: from MSG from the DISCUSSION LEADER OF RECOM*** Date: 15 Mar 1997 16:03:13 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 59 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar15.190356-0500_est.731914-174+1022@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net RE: THE SORRY STATE OF SPAMMING ON BIONET "Spamming" for the uninitiated is the art (if you can call it that) of cross posting the equivalent of mindless small talk or marketing info on thousands of news groups in one shot. It is annoying, makes some people extremely angry and most importantly uses up important bandwidth. I am writing to let the "faithful" few recombination news group followers that I will begin flooding the news group with all and any information on recombination. I am also privy to job postings from time to time so I will post them when ever I find, or receive jobs I feel are appropriate to the news group. I am the moderator of another news group bionet.genome.gene-structure as well and I am learning the in's and out's of moderating a group. This means filtering out all the garbage and reposting the real information and deleting the crap. When I feel proficient at this I will ask Bionet to set up moderation for this group. I have watched the group deteriorate with such spamming favorites as "**HOT SEX CHAT**" etc.... I think it is time to get back to the real reason this group was created. To exchange information and ideas about recombination. All comments, contributions and ideas are welcome. Talk to me people. Graham Dellaire RECOM ===================================== | Graham Dellaire | | Division of Experimental Medicine | Dept of Medicine, McGill University |(http://www.medcor.mcgill.ca/EXPMED/expmed.html) | | e-mail: dellaire@odyssee.net | Fax: (514) 896 4689 | Vox: (514) 281 6000 ext. 6936 | | Bionet: bionet.molbio.recombination | bionet.genome.gene-structure ===================================== | Snail Mail: | Institut du Cancer de Montreal | Centre de Recherch L.C. Simard | 1560 Sherbrooke St. East | Montreal, Quebec, CANADA | H2L 4M1 ===================================== From owner-recombination@net.bio.net Mon Mar 17 22:00:00 1997 Path: biosci!internet!biosci!not-for-mail From: biohelp (BIOSCI Administrator) Newsgroups: bionet.molbio.recombination Subject: BIOSCI/bionet miniFAQ & Fundraiser Date: 18 Mar 1997 02:00:09 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 239 Sender: daemon@net.bio.net Distribution: world Message-ID: <199703181000.CAA17710@net.bio.net> NNTP-Posting-Host: net.bio.net (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From owner-recombination@net.bio.net Tue Mar 18 22:00:00 1997 Path: biosci!ODYSSEE.NET!dellaire From: dellaire@ODYSSEE.NET ("Graham Dellaire") Newsgroups: bionet.molbio.recombination Subject: New on EMJL: Post Doc in nuclear/chromatin structure (globin) Dr. Peter Fraser Date: 19 Mar 1997 05:36:49 -0800 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 34 Sender: daemon@net.bio.net Distribution: world Message-ID: <97Mar19.083734-0500_est.471439-8582+1006@skywalker.microtec.net> NNTP-Posting-Host: net.bio.net NEW ON THE EXPERIMENTAL MEDICINE JOB LISTING (EMJL) PLEASE READ! REPLY TO THIS JOB LISTING VIA http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html#EURO under the Netherlands (all info. is for application is contained within these web pages) E-Mail sent to dellaire@odyssee.net will be deleted without comment **************************************************************************** *** POSTDOCTORAL POSITION in the Department of Cell Biology and Genetics studying the effects of nuclear/chromatin structure in the transcriptional regulation of the human beta-globin gene cluster. Three year fully funded postion supported by the NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek). Peter Fraser PhD Assistant Professor, Faculty of Medicine Dept. Cell Biology and Genetics Erasmus University Rotterdam TO APPLY PLEASE SEE http://www.medcor.mcgill.ca/EXPMED/DOCS/jobs.html#EURO From owner-recombination@net.bio.net Sat Mar 22 22:00:00 1997 Path: biosci!agate!newsgate.cuhk.edu.hk!news.glink.net.hk!news-hk.gsl.net!news.gsl.net!cyclic.gsl.net!news.gsl.net!newsfeed.internetmci.com!feeder.chicago.cic.net!cougar.olivet.edu!usenet From: IRST Newsgroups: bionet.molbio.recombination Subject: IRST Needs your help. Date: Tue, 18 Mar 1997 22:33:12 -0600 Organization: Olivet Nazarene University Lines: 108 Message-ID: <332F6C88.7A78@eggbeater.olivet.edu> NNTP-Posting-Host: r330a.chapman.olivet.edu Mime-Version: 1.0 Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit X-Mailer: Mozilla 4.0b2 (Win95; I) X-Priority: 3 (Normal) Dear Internet User, By now you've probably heard about the current issues pertaining to free speech and the regulation of Internet related materials. We, The Internet Regulatory Survey Team (IRST), are conducting a survey/study pertaining to these issues and are interested in your opinions. We are sending along a small 16 question survey that should take no more than five minutes of your time to complete. We ask for your participation in this study and provide us with your information. Your response will be completely anonymous. If you'd prefer to visit our Web site and fill out the form there the address is: http://eggbeater.olivet.edu/~survey/ Thank You in advance for your time! ----------------------------------------------- Internet Regulatory Survey 1. What service do you use to access the Internet? AOL Compuserve MSN Netcom Local Internet Service Provider (ISP) College or University LAN Other 2. How many times do you use Email during the week? 0-5 6-10 11-15 16-20 20+ 3. How many hours during the week do you spend on the Internet? 0-5 6-10 11-15 16-20 20+ 4. How long have you been using the Internet? 1-6 months 7-12 months 1-2 years 2-3 years 3+ years 5. How would you rate yourself as an Internet user? Beginner Intermediate Advanced Expert For questions 6-11 please indicate the level of agreement or disagreement for each. SA=Strongly Agree A=Agree N=Neutral D=Disagree SD=Strongly Disagree 6. The government should be allowed to regulate the Internet in general. SA A N D SD 7. How do you feel about laws governing material displayed on web sites? SA A N D SD 8. How do you feel about Internet service providers censoring email? SA A N D SD 9. A web site should be able to contain any information it wants no matter how vulgar, obscene, or derogatory it may be. SA A N D SD 10. Web sites should display a warning if they contain any material that may be questionable or offensive to others. SA A N D SD 11. All web sites should register their site with an Internet Censor Rating (ICR) company and display a censor rating, much like that used in television. SA A N D SD 12. Gender: Male / Female 13. Age: 14. Country: __________________ 15. Religious affiliation: Catholic Protestant Jewish Islamic Hindu Buddhist Other None 16. Political party: (U.S. Residents) Democrat Republican Independent Libertarian Other None (Non-US Residents) List political party name: _______________ ------------------------------------------------- We thank you for participation and encourage you to send us your comments and suggestions. Visit our Web site for more info Internet Regulatory Survey Team (IRST) WEB: http://eggbeater.olivet.edu/~survey/ EMAIL: survey@eggbeater.olivet.edu From owner-recombination@net.bio.net Mon Mar 24 22:00:00 1997 Newsgroups: bionet.molbio.recombination Path: biosci!daresbury!uninett.no!nntp.uio.no!news.maxwell.syr.edu!feed1.news.erols.com!howland.erols.net!rill.news.pipex.net!pipex!uknet!usenet1.news.uk.psi.net!uknet!uknet!bcc.ac.uk!news From: Paul Wells Subject: PRACTICAL INTRODUCTION TO GENETIC ENGINEERING COURSE Message-ID: <1997Mar25.145839.39164@ucl.ac.uk> Date: Tue, 25 Mar 1997 14:58:39 GMT Organization: University College London Lines: 33 A one week practical course designed to teach the basic techniques in genetic engineering will be held from 16th-20th June 1997 at the Dept. of Biochemistry and Molecular Biology University College London. A "hands on" approach will enable scientists from higher education and industry, clinicians and research workers who have had no practical experience of recombinant DNA technology to set up such techniques in their own laboratories. Techniques to be covered will include, Southern hybridisation DNA sequencing, PCR, and analysis of cloned DNA using enzyme restriction mapping. Supplemented with some lectures. Course fee 900 pounds sterling (750 for full time postgraduate students) exclusive of accomodation. Bed and breakfast accomodation for the period of the course can be provided in a local hall of residence for 102 pounds sterling from Sunday 15th June until Saturday 21st June. Write for application forms and further details to: Dr. John Ward Department of Biochemistry & Molecular Biology University College London Gower Street London WC1E 6BT Fax: 0171 380 7193 Or e-mail either:- j.ward@biochem.ucl.ac.uk p.wells@ucl.ac.uk