From owner-recombination@net.bio.net Sun May 02 23:00:00 1999 Path: biosci!biosci!not-for-mail From: art roberts Newsgroups: bionet.molbio.recombination Subject: Great New Website for Molecular Biologists Date: 3 May 1999 07:59:14 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 31 Sender: daemon@net.bio.net Approved: genestructure@yahoo.com Distribution: world Message-ID: <7gkdk2$gg6@net.bio.net> NNTP-Posting-Host: net.bio.net http://biotech.isCool.net This site allows easy access to hyperlinks and free software for the biochemist, biophysicist, and molecular biologist. This site is constantly evolving and expanding, so it can be easy to use, reliable, and comprehensive. This is purely a non-profit site for your enjoyment. Sincerely, Art Roberts (web designer) === Moderated bionet.genome.gene-structure _________________________________________________________ Do You Yahoo!? Get your free @yahoo.com address at http://mail.yahoo.com From owner-recombination@net.bio.net Mon May 17 23:00:00 1999 Path: biosci!biosci!not-for-mail From: "Mr Clive Delmonte" Newsgroups: bionet.molbio.recombination Subject: Recombination Complexes Date: 18 May 1999 02:49:52 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 119 Sender: daemon@net.bio.net Approved: genestructure@yahoo.com Distribution: world Message-ID: <7hrd40$7mq@net.bio.net> NNTP-Posting-Host: net.bio.net May I make a belated, and rather different contribution to the recent discussion in bionet newsgroups about the nature and purpose of "junk" DNA ? There is the possibility that the purpose of "junk" DNA is to enable long lengths of like-sequence, repetitive DNA to recognise each other, which could explain why it is needed in such long lengths. (I suspect we might only call it "junk" DNA because we haven't yet agreed a secure purpose for it.) Long lengths of repetitive DNA capable of recognising the same, or closely similar, repeat sequences could assist in the formation of the "30 nm" fibre of compacted nucleosomes, and in the assembly of centromeres. In addition, prior to cell division, the pairing of like chromosomes could be facilitated before separation during mitosis or meiosis, for example. The 13 pairs of human chromosomes would each need closely similar repeat sequences (each with the other), and these would need to be rather different from the repeat sequences in the other pairs. Perhaps subscribers know the repeat sequences of all of the human chromosomes ? The unique pairing of Watson-Crick base pairs, AT with AT and GC with GC, was described first by Loewdin in 1963, as far as I am aware. These properties of DNA and others are explored and developed in detail in my two books (1,2). In a single posting it is impossible to develop the arguments, but those wishing to consider fresh aspects of the behaviour of DNA may care to view the newsgroup "bionet.biophysics" to which I am currently posting the second series of DNA Structure Puzzles intended to focus attention on the wide range of experimental data which is otherwise unexplained in the literature. The attachments to the DNA Structure Puzzles in "bionet.biophsyics" include sketches of how individual base pairs can themselves form pairs, as well as a sketch of a model of DNA which facilitates such pairing. To any interested subscribers, I could send e-mail attachments of the scheme for pairing base pairs, and of the framework of the overall structure within which such pairing is facilitated. ------------------------------------------------------- 1 Towards a New Structural Molecular Biology,> by Clive Delmonte (1991) ISBN 0 9512276 0 2 "...I find much of Delmonte's critique of other workers sound enough to raise doubt in my mind about the bulk of the classical work in this area. ...the book was an eye-opener." Prof. Steven Benner at Eidgenossische Technische Hochscule, Zurich ------------------------------------------- "...the widely accepted Watson-Crick model is inadequate to explain many important pieces of data, and in some cases defies intuitive biological and physical logic as a predictive model..I commend you on your recognition of inconsistencies in the story of DNA..you have the potential of changing molecular biology." Prof. Robert Hopkins at the School of Applied and Natural Sciences in the University of Houston at Clear Lake, Texas ---------------------------------------------- 2 Advances in AFM & STM Applied to the Nucleic Acids, by Clive Delmonte (1997) ISBN 0 9512276 2 9, Library of Congress TX 4-856-037 ----------------------------------------------- Clive Delmonte Clive Delmonte E-mail: clived@ndirect.co.uk or: clivedelmonte@c-i-delmonte.freeserve.co.uk === Moderated bionet.genome.gene-structure _____________________________________________________________ Do You Yahoo!? Free instant messaging and more at http://messenger.yahoo.com