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From: jana.briestanska@img.cas.cz (Jana Briestanska)
Message-Id: <199502050023.AA14860@img.cas.cz>
Subject: M.D. seeks position in CANCER RES
To: rna@net.bio.net
Date: Sun, 5 Feb 1995 00:23:37 +0000 (CUT)
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My  name  is  Jana  Briestanska,  M.D.,  (grad.  in  1988),  I am
a woman-scientist seeking  postdoc position and  highly motivated
in cancer  research or molecular  genetics of oncogenes. I have
5 years of  experience in cloning,  sequencing, PCR, CAT  assays,
tissue  cultures  (transfections),  in  vivo  induction of tumors
(chicken model), immunoprecipitation.

My  current  research  deals  with  regulation  of src expression
influenced  by presence  of various  parts of  src 3'untranslated
region,  3'UTR,  (deletion  and  CAT  analysis,  now  prepared to
publication). Recently I tackled at detection of new open reading
frame  in  3'UTR  of  src.  As  to  used  methods I developed new
approach how to obtain recombinant DNA (see list of publications).

This  message includes curriculum vitae as well as 3 letters of
recommendation. I prefer human model and am ready to come
immediately.

My address is:


               email:  jana.briestanska@img.cas.cz

                                    or

                 FAX:  (422) 24 310 955

                                    or

          snail mail:  Jana Briestanska, M.D.
                       Institute of Molecular Genetics
                       Flemingovo n. 2
                       166 37 Prague 6
                       Czech Republic


Curriculum vitae:

1982-1988:  School of  Medicine University  of J.E.Purkyne (today
            University of Masaryk), Brno, Czech Republic

1983-1988:  Department  of Biology at  the same school as student
            assistant

1988-1995:  Institute of Molecular Genetics Prague,Czech Republic
            1990: Genetics engineering methods training course in
            Riga, Latvia (supported by UNESCO)
            1994: 5  weeks of visit  in Institute Curie-Biologie,
            Orsay, France.


Publications:

            J.Briestanska   1990.    Microtubular   dynamics   of
            Saccharomyces     cerevisiae    temperature-sensitive
            secretory   mutants:   The    sec   1   product   and
            polymerization of microtubules.  Folia Biologica. 36,
            312-318.

            J.Briestanska,  and   J.Svoboda  1993.  The   use  of
            directed  ligation   for  obtaining  high   yield  of
            recombinant  DNA  and   for  efficient  transcloning.
            Biotechniques. 15, 220-222.

            J.Briestanska, and J.Plachy 1995. Regulation of tumor
            growth  induced  by  src  with  various  parts of its
            3'untranslated region (in preparation).

            B.Yatsula,    J.Geryk,    J.Briestanska,   I.Karakoz,
            J.Svoboda,  A.V.Rynditch.  G.Calothy,  and  P.Dezelee
            1994. Origin  and evolution of  the c-src transducing
            avian  sarcoma   virus  PR  2257.   J.Gen.Virol.  75,
            2777-2781.

            P.Dezelee,  J.Barnier,    J.Briestanska,   J.Geryk,
            I.Karakoz, A.A.Michailik, J.Nehyba, B.A.Yatsula, A.V.
            Rynditch, G.Calothy, and J.Svoboda  1994. New case of
            c-src gene  transduction: The generation  of virus PR
            2257. Folia Biologica. 40, 211-223.


Posters:

            M.Havelkova, J.Briestanska, J.Filkuka 1984. Polyploid
            nuclei  in  yeast  protoplasts.  IX  Biological Days.
            Hradec Kralove, Czech Republic (in Czech).

            M.Havelkova, and J.Briestanska 1986. Cytospectrophoto
            metry  - a  method convenient  for measuring  minimal
            amounts of DNA. IX Days of Medical Biophysics. Karlov,
            Czech Republic (in Czech).

            M.Havelkova,  and  J.Briestanska  1987.  Microtubular
            structures in yeast protoplasts. X Biological Days.
            Brno, Czech Republic (in Czech).


Awards:

            In 1988  I was awarded  by the minister  of education
            for excellent  study results and  scientific activity
            in School of Medicine in Brno, Czech Republic.
-----------------------------------------------------------------

                    Letter of recommendation I



     Jana Briestanska,  M.D., already during  her studies on  the
School of Medicine became interested  in research in the field of
molecular  biology  of  cancer.  (This  is  rather  unusual - for
medicine  students  a  career  in  research  or  teaching  is not
attractive at all).

     Shortly after receiving her M.D. degree, she started working
in the  Institute of Molecular Genetics,  Prague. She learned the
principles and  methods of molecular genetics;  she also attended
courses on molecular biology.


     Jana Briestanska  is a very  enthusiastic scientist, working
every day till late hours. She  succeeded to develop a new method
for  producing recombinant  DNA. The  topics of  her work  is the
3'noncoding segment of src gene,  in which she discovered several
regulatory elements  and indeed confirmed their  function both in
in  vitro  as  well  as   in  in  vivo  experiments  in  chicken.
Manuscripts for publication are in preparation. Molecular biology
of cancer is all time the centre of all her interests.

     J. B. is a person sticking  to her strict principles; she is
critical  to others  as well  as to  herself. She  is a  nice and
communicative person.

     I  am  sure  that  J.  B.  is  a  talented  and  prospectful
scientist.  No doubt,  a longer  stay in  a good institute abroad
would greatly stimulate her further scientific growth. Thus I can
recommend her application indeed sincerely.




January 20, 1995


                              prof.Jan Zavada, Ph. D.

                            Institute of Molecular Genetics
                              Academy of Sciences of C.R.

                                   Flemingovo n. 2
                             166 37 Prague, Czech Republic

                            FAX: (422) 24 310 955
                            E-mail: zavada@img.cas.cz

-----------------------------------------------------------------


                    Letter of recommendation II


                 Masaryk University Brno, Czech Republic

                       Department of Biology


To whom it may concern



     I have  known Jana Briestanska, M.D.,  since she entered the
Faculty of Medicine in Brno. She was one of the best students
in  her year.  From the  very beginning  of her  studies, she was
deeply  interested in  science and,  as a  student-voluntier, she
joined  a research  team at  the Department  of Biology  studying
yeast   cytology,   with   particular   interest   in  cell  wall
regeneration   and  cytoskeleton   functions.  She   showed  good
laboratory skills  and experimental invention. She  was a gifted,
self-disciplined and determined student willing to spend her free
time in the laboratory. I have been told that she shows that same
quality  and attitude  in her  present work  at the  Institute of
Molecular Genetics of the Czech Academy of Sciences in Prague.

     I can recommend Jana Briestanska, M.D., a talented and hard-
working researcher, to any biological laboratory.


                           prof.A.Svoboda, M.D.,Ph.D.


                           FAX: (425) 421 262 00



-----------------------------------------------------------------
                    Letter of recommendation III


Worked out by Jiri Plachy. Ph.D.


     J Briestanska,  M.D., has been  working in the  Institute of
Molecular  Genetics  since  1988.  In  this  place  she  attained
experience in  methods of molecular  genetics namely in  cloning,
sequencing   and  PCR   techniques.  She   proved  her   research
independence also by establishing  new methodical approach in our
lab  that has  not been  used yet  (J.Briestanska and  J.Svoboda,
1993. The use  of directed ligation for obtaining  high yields of
recombinant  DNA and  for efficient  transcloning. Biotechniques.
15,  220-222.). She  uses a  tissue culture  techniques in vitro,
too, and she participated in in vivo experiments on defined lines
of chickens.

     I co-worked with Dr.Briestanska last two years on regulation
of tumor growth induced by inoculation of plasmid constructs with
src  oncogene via  3'untranslated region.  In this  time I got to
know her  as a woman-colleague  with a great  working motivation,
wide scientific horizon, and  critical approach to interpretation
of experimental data.


                             Dr.J.Plachy, Ph.D.


                             Institute of Molecular Genetics
                             Academy of Sciences of C.R.
                             Flemingovo n. 2
                             166 37 Prague 6, Czech Republic

                             FAX: (422) 24 310 955

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subscribe RNA news group

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From: Harry Karatassos <karatassos+@CMU.EDU>
To: rna@net.bio.net
Subject: Nucleic Acid and Protein Sequence Analysis workshop at the PSC


                   NUCLEIC ACID AND PROTEIN SEQUENCE ANALYSIS   
                       WORKSHOP FOR BIOMEDICAL RESEARCHERS  
                              Pittsburgh, Pennsylvania  
				June 4-9, 1995


  
Pittsburgh Supercomputing Center (PSC) is again offering a five-day workshop on
"Nucleic Acid and Protein Sequence Analysis," June 4-9, 1995.  It is  
funded by a grant from the National Center for Human Genome Research of 
the National Institutes of Health.     
  
The workshop will familiarize biomedical researchers with computational  
methods and provide practice in applying supercomputing resources to
problems of concern in macromolecular sequence analysis.  Emphasis will be
on alignment of and pattern extraction from multiple sequences.   
Participants will gain practical experience on PSC's Cray C-90 and T3D in 
(1) comparing and aligning sequences, (2) identifying informative patterns 
in a set of sequences; and (3) using extracted informative patterns to 
identify related sequences.  Researchers will also learn several approaches 
to database searching and  multiple sequence alignment, how to use profile 
analysis effectively, and how to identify patterns in their sequences.   
Participants are encouraged to bring sequence analysis problems from their 
current research.  Extensive documentation will be given at the outset on 
the PSC computing environment as well as on the specific programs
to be employed in the workshop.  No prior supercomputing experience is 
required.
    
Workshop leaders are Dr. Gary Churchill, Cornell University, Dr. Michael 
Gribskov, San Diego Supercomputing Center, and Dr. Hugh Nicholas, PSC.
  
A limited number of grants to cover travel and hotel accommodations are
available for U.S. academic participants.  ALL PARTICIPANTS ARE REQUIRED 
TO PAY A $135 REGISTRATION FEE, IN ADVANCE, UPON ACCEPTANCE INTO THE WORKSHOP. 
The deadline for submitting applications is April 17, 1995.  Enrollment is
limited to 20 participants.  
   
Additional information about this workshop can be found in             
http://pscinfo.psc.edu/biomed/workshops95.html



				      * * * * *




			  PITTSBURGH SUPERCOMPUTING CENTER
                     NUCLEIC ACID AND PROTEIN SEQUENCE ANALYSIS 
                        WORKSHOP FOR BIOMEDICAL RESEARCHERS
                                June 4-9, 1995
        		

		                   APPLICATION


Name:	       ________________________________________________________________

Affiliation:   ________________________________________________________________

Address:       ________________________________________________________________
	       (Business)
	       ________________________________________________________________

	       ________________________________________________________________
	       (Home)
	       ________________________________________________________________

Telephone:  ____________________________         ______________________________
	           (Business)				     (Home)

*Social Security Number:  _______-_____-_______	Citizenship:___________________

Electronic Mail Address:_______________________________________________________

Status: ___Graduate  ___Post-doctoral Fellow  ___Faculty  ___Other (specify)

In order to attend the workshop, will you need funds for travel?___ lodging?___

Please indicate specifically any special housing, transportation or dietary 
arrangements you will need: __________________________________________

How did you learn about this workshop:_________________________________________

REQUIREMENTS:

Applicants must submit a completed application form and a cover letter.  The
letter should describe, in one or two paragraphs, the sequence analysis 
problems encountered in your research, and how participating in the workshop 
will enhance this research.  Please include a brief statement describing your 
level of experience with computers.  Faculty members, staff and post-docs 
should provide a curriculum vita.  Graduate students must have a letter 
of recommendation from a faculty member. If you have requested travel funds, 
please include the cost of roundtrip air fare from your home to Pittsburgh and 
indicate the amount of travel funds you will need. ALL PARTICIPANTS WILL BE 
REQUIRED TO PAY A $135 ADVANCE REGISTRATION FEE UPON ACCEPTANCE INTO THE 
WORKSHOP.

Please return all application materials by APRIL 17, 1995 to:

  Biomedical Workshop Applications Committee
  Pittsburgh Supercomputing Center
  4400 Fifth Avenue, Suite 230C
  Pittsburgh, PA 15213

Direct inquiries to: Nancy Blankenstein, blankens@psc.edu or 412/268-4960.

*Disclosure of Social Security Number is voluntary.

PSC does not discriminate on the basis of race, color, religion, sex, age,
creed, national or ethnic origin, or handicap.




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Date: Fri, 10 Feb 1995 16:59:04 -0500 (EST)
From: Harry Karatassos <karatassos+@CMU.EDU>
To: rna@net.bio.net
Subject: NMR workshop offered at the PSC





                  STRUCTURE DETERMINATION FROM NMR
                    Pittsburgh Supercomputing Center           
                           June 25-28, 1995


Pittsburgh Supercomputing Center (PSC) is offering biomedical researchers a
"Structure Determination From NMR" Workshop.  The objective is to introduce 
participants to the different techniques for the elucidation of solution
structures of biological macromolecules from nuclear magnetic resonance data.
The workshop is free to academic participants.


The worskhop will consist of lectures and extensive hands-on sessions.
The programs AMBER, Mardigras and MidasPlus will be discussed.  Hands-on 
sessions will be emphasized. 
Participants will be able to work on the examples 
provided or on their own experimental data. 
No prior supercomputing experience is necessary.  

Workshop leaders are: Dr. David Case, The Scripps Research Institute; and 
Drs Thomas James, Julie Newdoll and Uli Schmitz, 
University of California, San Francisco.

This workshop is funded by a grant from the Biomedical Research Technology
Program, National Center for Research Resources, National Institutes of 
Health.  Travel, meals and hotel accommodations for researchers affilated 
with U.S. academic institutions are supported by this grant. Enrollment is 
limited to 20.  An application form is included.  Deadline for applications 
is: April 28, 1995.

Additional information about this workshop can be found in 
http://pscinfo.psc.edu/biomed/workshops95.html




                             * * * * * * * * * *



			PITTSBURGH SUPERCOMPUTING CENTER

			     BIOMEDICAL  INITIATIVE 
		       STRUCTURE DETERMINATION USING NMR
				June 25-28, 1995

				APPLICATION  


Name:________________________________________________________________________ 
 
Affiliation:_________________________________________________________________

Address:_____________________________________________________________________
                                  (Business) 
_____________________________________________________________________________
                  
____________________________________________________________________________
                                    (Home)                  
____________________________________________________________________________ 
 
Telephone:  ____________________              ______________________ 
                (Business)                            (Home) 
 
*Social Security Number:  _______-_____-_______    Citizenship: ____________

Electronic Mail Address:____________________________________________________ 

Status: ___Graduate  ___Post-doctoral Fellow  ___Faculty  ___Other (specify) 
 
Please indicate specifically any special housing, transportation or dietary 
arrangements you will need:  _______________________________________________
 
How did you learn about this workshop? _____________________________________

    
REQUIREMENTS: 

Applicants must submit a completed application form and a cover letter. The 
letter should describe, in one or two paragraphs, your current research and  
how participating in the workshop will enhance this research.  Please 
include a brief statement describing your level of experience with computers. 
Faculty members, staff and post-docs should provide a curriculum vita. 
Graduate students must have a letter of recommendation from a faculty member.  
 
Please return all application materials by APRIL 28, 1995 to:

          Biomedical Workshop Applications Committee 
          Pittsburgh Supercomputing Center 
          4400 Fifth Avenue, Suite 230C 
          Pittsburgh, PA 15213 
 
Direct inquiries to: Nancy Blankenstein, blankens@psc.edu or 412/268-4960.

*Disclosure of Social Security Number is voluntary.

PSC does not discriminate on the basis of race, color, religion, sex, age, 
creed, national or ethnic origin, or handicap. 
 

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Date: Fri, 10 Feb 1995 17:05:31 -0500 (EST)
From: Harry Karatassos <karatassos+@CMU.EDU>
To: rna@net.bio.net
Subject: MM and MD of Biopolymers workshop  at the PSC



 "METHODS OF MOLECULAR MECHANICS AND DYNAMICS OF BIOPOLYMERS" WORKSHOP
                    Pittsburgh Supercomputing Center           
                           August 16-19, 1995


        The Pittsburgh Supercomputing Center (PSC) is hosting a workshop 
 on "Methods of Molecular Mechanics and Dynamics of Biopolymers," 
 August 16-19, 1995.  
        The workshop will familiarize biomedical researchers with 
computational methods and provide practice
in applying supercomputing resources to problems of concern in molecular 
mechanics.  Practical experience on our supercomputers will be gained in  
the application to: 
(1) the theory and practice of molecular mechanics and dynamics;  
(2) the development and refinement of molecular mechanics force fields; 
(3) the problem of conformation mapping and analysis of polypeptide 
structures, including the refinement of structure from measured NMR data; 
and 
(4) computation of interaction energies and free energies for protein-drug
interactions and conformational thermodynamics.  

 Workshop leaders are
 Dr. Charles L. Brooks III, The Scripps Research Institute 
and 
Dr. Alexander D. MacKerell Jr., University of Maryland at Baltimore.

The worskhop will consist of lectures and extensive hands-on sessions.
General aspects of molecular mechanics software will be discussed and
 a number of packages are available for use at the PSC.  However, 
the programs CHARMM and QUANTA will be utilized most extensively in 
demonstrations.  Hands-on sessions will be emphasized. 
Participants will be able to work on the examples provided or 
on their own experimental data. 
No prior supercomputing experience is necessary.  

This workshop is funded by a grant from the Biomedical Research Technology
Program, National Center for Research Resources, National Institutes of 
Health.  Travel, meals and hotel accommodations for researchers affilated 
with U.S. academic institutions are supported by this grant. Enrollment is 
limited to 20.  An application form is included.  Deadline for applications 
is: June 22, 1995.
Please direct inquires or send the following application form to 
blankens@psc.edu.


Additional information about this workshop can be found in 
http://pscinfo.psc.edu/biomed/workshops95.html



			PITTSBURGH SUPERCOMPUTING CENTER

			     BIOMEDICAL  INITIATIVE 
		       **************************************
			       August 16-19, 1995

				APPLICATION  


Name:________________________________________________________________________ 
 
Affiliation:_________________________________________________________________

Address:_____________________________________________________________________
                                  (Business) 
_____________________________________________________________________________
                  
____________________________________________________________________________
                                    (Home)                  
____________________________________________________________________________ 
 
Telephone:  ____________________              ______________________ 
                (Business)                            (Home) 
 
*Social Security Number:  _______-_____-_______    Citizenship: ____________

Electronic Mail Address:____________________________________________________ 

Status: ___Graduate  ___Post-doctoral Fellow  ___Faculty  ___Other (specify) 
 
Please indicate specifically any special housing, transportation or dietary 
arrangements you will need:  _______________________________________________
 
How did you learn about this workshop? _____________________________________

    
REQUIREMENTS: 

Applicants must submit a completed application form and a cover letter. The 
letter should describe, in one or two paragraphs, your current research and  
how participating in the workshop will enhance this research.  Please 
include a brief statement describing your level of experience with computers. 
Faculty members, staff and post-docs should provide a curriculum vita. 
Graduate students must have a letter of recommendation from a faculty member.  
 
Please return all application materials by June 22, 1995 to:

          Biomedical Workshop Applications Committee 
          Pittsburgh Supercomputing Center 
          4400 Fifth Avenue, Suite 230C 
          Pittsburgh, PA 15213 
 
Direct inquiries to: Nancy Blankenstein, blankens@psc.edu or 412/268-4960.

*Disclosure of Social Security Number is voluntary.

PSC does not discriminate on the basis of race, color, religion, sex, age, 
creed, national or ethnic origin, or handicap. 
 



