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Date: Tue, 1 Oct 1996 16:53:42 -0700 (PDT)
From: James Lyons-Weiler <weiler@ers.unr.edu>
To: rna@net.bio.net
cc: dinosaur@lepomis.psych.upenn.edu, roots-l@vm1.nodak.edu,
        mollusca@ucmp1.berkeley.edu
Subject: Free Phylogenetics Software - RASA 2.0 (fwd)
Message-ID: <Pine.LNX.3.95.961001165229.24633J-100000@earth.ers.unr.edu>
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(Apologies for semi-redundant or cross postings)

Date of Upgrade: October 1, 1996

*********************************************************************
*********************** Announcing RASA 2.0 *************************
*********************************************************************

	Software for the Mac that will perform "Relative Apparent
	Synapomorphy Analysis" (RASA) has been updated and is freely
	available at the address below.  RASA is a statistical test 
	for the presence of phylogenetic signal (a.k.a. cladistic 
	hierarchy) in _any_ type of discrete character data matrix
	(morphological/molecular/combined).
	
	RASA belongs to the family  of inferential statistics, which 
	focuses on hypothesis testing.  Functionally, the test compares
	the observed and null rates of increase in cladistic similarity 
	among pairs of taxa predicted by an increase in the phenetic 
	similarity among taxon pairs.  The test statistic follows 
	Student's t distribution (cf., a t-test).  
	
The software (updated from 1.1.1 to 2.0) is now available FREE 
at the following URL as a binhexed self-extracting archive:

	http://loco.biology.unr.edu/archives/rasa/rasa.html

and by anonymous ftp at

	loco.biology.unr.edu (pub) (rasa)

There you'll find rasa.sea, which contains the following:

		RASA 2.0        <-- Reads a data file, measures signal,
			            reports the result in tabular form,
                                    AND allows you to plot and explore
                                    the RASA regression. RASA 2.0 replaces
                                    RASA 1.1.1 and RASA Plot 1.1.1.
                            
             sample.data        <-- A sample data file with signal.

	      README-2.0        <-- A file with FAQs, bugs, etc.

	     SoftwareFPU        <-- Allows FPU machines to run
                                    RASA 2.0.
		
	      PLUS LINKS to other Phylogenetic Information on the Web.

**** CHANGES IN 2.0 ****

	RASA 2.0 is much more sophisticated and user friendly than 1.1.1:

		User interface
			Menu-driven analyses 
			Menu-driven graphics
			Identify specific taxa in the RASA regression
			(RASA Plot is now incorporated into 2.0)
	
		Data entry
			No more COMMAS between characters!
			See new sample data file for data entry format
			
		Data analysis
			Multiple outgroups can be defined.
		
		Planned Upgrades
			Printing capability will be added.
		
			Including/Excluding Taxa will be added.
		
			New analytical tools for phylogenetic data
                        exploration based on the RASA test will be
                        implemented _after_ they have survived peer
                        review.

			RASA 2.0 will be upgraded after each analysis is 
			implemented. Check for upgrades monthly.

The reference for the algorithm and detailed justification and discussion
of limitations of the approach can be found in:

	Lyons-Weiler, J., G.A. Hoelzer, and R.J. Tausch. 1996. Relative
	Apparent Synapomorphy Analysis (RASA) I: the statistical
        measurement of phylogenetic signal.  Molecular Biology and
        Evolution 13:749-757.

Send questions off the list; FAQs will be included in the README file as
they arrive.

To add your name to the RASA mailing list, or if you have questions, send
an email with your postal to

weiler@ers.unr.edu


James Lyons-Weiler

Ecology, Evolution, and Conservation Biology
1000 Valley Road/186
University of Nevada, Reno
Reno, NV 89512





From BIOSCI-REQUEST  Wed Oct  9 02:00:20 1996
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Date: Wed, 9 Oct 1996 02:00:09 -0700
From: BIOSCI Administrator <biohelp>
Message-Id: <199610090900.CAA24204@net.bio.net>
To: rna@net.bio.net
Subject: BIOSCI/bionet miniFAQ & Fundraiser

(LAST REVISION: 30-JUL-95)

This BIOSCI "miniFAQ" is designed to answer the questions that come up
the *most frequently*.  The main BIOSCI FAQ (Frequently Asked
Questions) is accessible on the World Wide Web at URL
http://www.bio.net/.

If you can not find an answer to your question in this or other
documentation, the BIOSCI technical support staff answers e-mail
queries sent to

		       biosci-help@net.bio.net

We can only answer questions about the use of the newsgroups and
mailing lists.  We unfortunately do not have the staff to do Internet
information searches or answer scientific questions.  Please post
those to the appropriate BIOSCI/bionet newsgroups.


	Contents:
	--------
	0) BIOSCI NEEDS YOUR SUPPORT!!

	1) Using the WWW to access the BIOSCI/bionet newsgroups.

	2) What to do about "spams," i.e., junk mail, ads, etc.

	3) Examples of subscribing and unsubscribing to the mailing lists.

	4) The BIOSCI user address and research interest directory.


0) BIOSCI NEEDS YOUR SUPPORT!!
------------------------------
BIOSCI's government funding has been expended, and we are now
operating solely from advertising revenue that we have raised from our
Web site at http://www.bio.net/.  We need just a few minutes of your
time to help us serve you.

You can do two important things which will take very little time for
you individually and will immensely help us continue to help you.

First, please use our WWW system at http://www.bio.net/ to access the
archives.  You can post or reply to messages via your Web browser as
described in item #1 below.  Your usage helps attract sponsors. If you
contact any of our sponsors, please be sure to thank them for
supporting BIOSCI. It is critical for them to get this feedback if
they are to continue their sponsorship for the long term.

Second, if you work for a company or organization that provides
products or services of interest to the biology community, please pass
this message on to your marketing or marketing communications
department or other appropriate group.  Please ask them to help
support BIOSCI by sponsoring our Web site and explain the uses and
benefits of the system to the biology community. If they are
interested, they can then contact us for further information at our
tech support address, biosci-help@net.bio.net.


1) Using the WWW to access the BIOSCI/bionet newsgroups.
--------------------------------------------------------
As of 10 December 1995, all BIOSCI/bionet full newsgroups are
accessible through the World Wide Web (WWW) at URL http://www.bio.net.
One can read and reply publicly or privately to both recent postings
and archived messages through one's Web browser if it is configured
properly to send e-mail.  Each newsgroup is equipped with its own WAIS
index.  The main BIOSCI home page also has access to the BIO-JOURNALS
Table of Contents database WAIS index and the BIOSCI user address
database described in another item further below.


2) What to do about "spams," i.e., junk mail, ads, etc.
-------------------------------------------------------
BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups),
mailing lists, and a hypermail archive at URL http://www.bio.net/.
The same postings are distributed on all media (except for a small
number of mailing-list-only groups at net.bio.net).  Unfortunately it
is becoming a despicable practice on the Internet (by a few people out
to make a fast buck) to do automated mass postings to thousands of
newsgroups and mailing lists.  These attempts to grab free advertising
are refered to as "spams" in the usual, somewhat boneheaded, net
terminology.  USENET is more susceptible to this practice, and many
spams originate on the USENET groups and then are passed on to the
mailing lists.  However, spammers also get lists of mailing addresses
and hit these too, so neither medium is immune.

What should you do personally if you get junk mail?
---------------------------------------------------
Just delete it and move on without reading it further.  Filing a
protest is becoming increasingly useless because spammers are often
disguising the addresses where the messages are sent from.  Unless you
really understand Internet mail systems, your attempt at protest by
sending replies to the message will often end up being sent to the
address of an innocent person that the spammer is victimizing.

What can BIOSCI/bionet do to protect its newsgroups?
----------------------------------------------------
The only solution currently available is to moderate the newsgroup.
If this newsgroup is already moderated, then you are in good shape.
Moderation protects the USENET distribution from about 95% of the
spams that are being sent to date and protects the mailing lists
completely.  Moderation means, however, that someone has to take the
time to review each message before it goes out.  We have set up
software here that simply allows the moderator to forward to an
address at net.bio.net messages that (s)he wishes to have distributed.
This takes no more time than that needed to read the message and pass
it on, say about 1 min. per message.

Most newsgroups currently have a discussion leader who is responsible
for their newsgroup.  The discussions leaders and their e-mail
addresses are listed in the BIOSCI Information Sheet which is
available on the Web at http://www.bio.net/.  If a newsgroup is being
hit with too many junk postings, please contact the discussion leader
for that group and see if there is interest in moderating the group.
Please do not assume that by simply posting a complaint to the
newsgroup itself, anyone on the BIOSCI staff will act on your
complaint.  With close to 100 newsgroups to run, the BIOSCI staff has
to rely on the discussion leaders of each newsgroup to report problems
directly to us at biosci-help@net.bio.net.

We will moderate any of our newsgroups if the discussion leader tells
us that the readership of the group wishes to do so and if a moderator
is willing to do the work.  For most BIOSCI/bionet groups, this
entails only a few minutes of work each day.

Moderating a newsgroup will resolve probably 95% of the junk postings
on the USENET distribution.  Unfortunately there are easy ways for
determined spammers to override the moderation mechanism on USENET,
but we can protect our e-mail subscribers from unwanted postings if
the newsgroup is moderated.  You can also access our newsgroups over
the WWW at URL http://www.bio.net.  While this Web interface will not
stop spammers from trying to post to the groups, this will give you
yet another way, besides using USENET news, to keep the junk out of
your personal mail files.  For those of you with local USENET news
systems, the Web interface will also give you faster access to new
newsgroups and recent postings.


3) Examples of subscribing and unsubscribing to the mailing lists.
------------------------------------------------------------------
PLEASE NOTE: The BIOSCI management does NOT act on
subscription/unsubscription requests that are posted improperly to the
newsgroups and mailing lists.  People who do this only bother everyone
on the lists to no avail.  Please be sure to follow the proper
procedures below.

Gory details are in the BIOSCI Information sheets on the Web at
http://www.bio.net.  Below we give an example utilizing the
METHODS-AND-REAGENTS list at both of our two BIOSCI sites:

Users in the Americas and Pacific Rim countries who use the BIOSCI
------------------------------------------------------------------
node at computer net.bio.net:
----------------------------

A) Determine the "listname" which is the <=8 character mail address
                                         ^^^^^^^^^^^^^
   for the group.  These can be found in the BIOSCI Info. Sheet.  For
   the METHODS-AND-REAGENTS group the mailing address is
   methods@net.bio.net.  The listname is the portion of the address to
   the left of the @ sign, i.e., "methods".  The listname is used with
   the "subscribe" and "unsubscribe" commands illustrated below.

B) Mail all commands in the body of a mail message addressed to
   biosci-server@net.bio.net.  Do NOT send commands to the newsgroup
   posting addresses!  Leave the Subject: line blank, any text on it
   will be ignored.

C) In the body of your message put one or more of the following
   commands with an "end" command on the last line, e.g.,

   subscribe methods
   unsubscribe methods
   end

   Do NOT put your e-mail address or other text on these lines.  The
   server only allows you to cancel your subscription if the address
   on your mail header matches the address on our mailing list.
   Please ask for help at biosci-help@net.bio.net if your address has
   changed, e.g., if you know you are on the list but the server tells
   you that you are not a member.


Users in Europe, Africa, and Central Asia who use the BIOSCI node at
--------------------------------------------------------------------
computer daresbury.ac.uk (also known as dl.ac.uk):
-------------------------------------------------

To subscribe and unsubscribe to/from the BIOSCI lists, you need to
specify the full USENET newsgroup name with "bionet-news." prepended.
The USENET newsgroup names are listed in the BIOSCI Information sheet
on the Web at http://www.bio.net/.  For the METHODS-AND-REAGENTS list
the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the
appropriate commands are

    sub bionet-news.bionet.molbio.methds-reagnts

    unsub bionet-news.bionet.molbio.methds-reagnts

These commands are included in a message addressed to mxt@dl.ac.uk,
NOT to the newsgroup mailing addresses.  As usual, include the text in
the body of the message as text on the Subject: line is ignored.

To unsubscribe from all the lists at the UK node, use

    unsub bionet-news

Please note that if the address in the list is different than the one
in your mail message header, you will not be able to unsubscribe by
this method. If you have problems, please mail biosci@daresbury.ac.uk.


4) The BIOSCI user address and research interest directory.
-----------------------------------------------------------
Please take this opportunity to add your name, address, and research
interest information to the BIOSCI User Address Database if you have
not already done so.

You can fill out the address form directly through our Web page at URL
http://www.bio.net/adrform.html.

The address database is reindexed nightly for WWW access (the URL is
http://www.bio.net/).  If you are not directly on the Internet but can
reach it by e-mail, please use our waismail server to access the user
directory.  waismail use is described above.  You can also request a
user address form by e-mail from biosci-help@net.bio.net.

Please check your database entry from time-to-time to see if your
address information is still up-to-date.  Because of our limited
personnel resources, we ask that you resubmit a *complete* form to
revise your entry; we only replace complete entries and do not have
resources to edit old forms.

				Sincerely,

				Dave Kristofferson
				BIOSCI/bionet Manager

				biosci-help@net.bio.net

From BIOSCI-REQUEST  Tue Oct 15 09:27:08 1996
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From: "Tim Stabler" <TSTABLER@iunhaw1.iun.indiana.edu>
Organization:  Indiana University Northwest
To: rna@net.bio.net
Date:          Tue, 15 Oct 1996 11:27:22 CST
Subject:       Re: Meeting
Reply-To: tstabler@iunhaw1.iun.indiana.edu
Priority: normal
X-Mailer: Pegasus Mail v3.22
Message-Id: <4EAC006F7@iunhaw1.iun.indiana.edu>

I would like to announce that next year, June 14-18, the Society for 
In Vitro Biology will be holding its Congrtess at the Renaissance 
Hotel in Washington, D.C.  Various symposia and workshops are 
planned, some of which directly interface with this group.

If you would like further information, please Email me your snail-
mail address and I will get it to you immediately.  Or, if you are 
into the Web, you can look up "SIVB" on your net search.  Especially, 
if you are using Netscape Navigator and the "Infoseek" area.  There 
you will find all sorts of information about the group, past meetings 
and plans for this meeting.

If you wish, you might be able to be a poster presenter or speaker.  
I can get you that information also.  There will be an exhibit area 
from various companies.

If you Email me, please note that in my address it is "iunhaw(one)" 
and not an "L" there.  I have had several folks make this mistake.

Thanks for you time.

Timothy A. Stabler, Ph.D.
Department of Biology
Indiana University Northwest
Gary, IN 46408

(219)980-6718
FAX: (219)980-7125


Timothy A. Stabler, Ph.D.
Department of Biology
Indiana University Northwest
Gary, IN 46408

(219)980-6718
FAX: (219)980-7125

From BIOSCI-REQUEST  Tue Oct 15 20:37:43 1996
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	id AA14991; Wed, 16 Oct 1996 13:07:53 +0930 (from ggoodall@immuno.imvs.sa.gov.au for rna@net.bio.net)
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From: "GREG GOODALL" <ggoodall@immuno.imvs.sa.gov.au>
Organization: Institute of Med. & Vet. Science
To: rna@net.bio.net
Date: Wed, 16 Oct 1996 13:06:41 GMT+1030
Subject: post-doc position 
X-Confirm-Reading-To: "GREG GOODALL" <ggoodall@immuno.imvs.sa.gov.au>
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Priority: normal
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I am looking for a post-doctoral fellow to join my lab to study the 
function/mechanism of a newly discovered mRNA-destabilising element 
that is present in a number of growth factor mRNAs (PNAS, in press).

Anyone interested please contact me for further information.

Greg Goodall
ggoodall@immuno.imvs.sa.gov.au

Dr. Greg Goodall
Hanson Centre for Cancer Research
I.M.V.S.
Frome Road
Adelaide, S.A. 5000
Australia

From BIOSCI-REQUEST  Thu Oct 17 15:03:43 1996
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Content-Type: text/plain; charset="us-ascii"
Date: Thu, 17 Oct 1996 17:06:40 -0600
To: rna@net.bio.net
From: shura@uic.edu (Alexander Mankin (Shura))
Subject: biotinylated RNA

We need an advice for introducing biotin in the RNA 3' or 5' end. We cannot
use periodate chemistry and thus have to use an enzymatic approach. There
is biotinylated UTP on the market. Does anyone know if terminal
deoxynucleotidyl transferase will add rNTP or dNTP to the RNA 3' end? Any
reference?
Are there any good biotinilated substrates for RNA ligase?
Would anyone have other ideas of how to biotinylate RNA end?
Cheers. Alexander Mankin



From BIOSCI-REQUEST  Tue Oct 22 17:01:09 1996
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Date: Tue, 22 Oct 1996 17:56:08 -0600
From: scistra@cs.sandia.gov (Sorin C. Istrail)
Message-Id: <199610222356.RAA02181@frodo2.cs.sandia.gov>
To: rna@net.bio.net
Subject: RECOMB 97: CALL FOR POSTERS; LIST OF ACCEPTED PAPERS



     RECOMB 97 NEWS 
     **************
 
     October 22, 1996




  1. REMINDER: CALL FOR POSTERS (deadline Oct 25, 96)

  2. List of accepted papers to RECOMB 97





 ------------------------------------------------

               FIRST ANNUAL INTERNATIONAL CONFERENCE ON
                
                    COMPUTATIONAL MOLECULAR BIOLOGY

                           (RECOMB 97)



                       January 20-23, 1997                     
                          Eldorado Hotel
                       Santa Fe, New Mexico
                       
                          Sponsored by 
 
                           ACM SIGACT

                        with support from

                         SLOAN Foundation 
                      US Department of Energy

                        recomb97@hto.usc.edu
                 http://www.cs.sandia.gov/recomb97

  -------------------------------------------



  1. This is a reminder that the deadline for receiving a poster
     abstract for RECOMB 97 is OCTOBER 25, 1996.

     This call is for a one page abstract. The actual space for
     the poseter presentation will be a regular poster space 
     accomodating about 15 pages.

  
         Call for RECOMB 97 Posters
         **************************

    Please send a one-page abstract of your Poster including title, 
    authors, affiliation and abstract-text *preferably* via email to

                        recomb97@hto.usc.edu

    or hard copy to:

                        Professor Michael Waterman
                        RECOMB 97 Program Chair
                        University of Southern California
                        Department of Mathematics, DRB 155
                        Los Angeles, CA 90089-1113

    Deadline for poster abstract submission: October  25, 1996
    Notification of acceptance/rejection:    November 15, 1996



 ---------------------------------------------

 2. The List of Accepted Papers for RECOMB 97:
    ******************************************


Name: Zheng Zhang, William R. Pearson, Webb Miller
Title: Aligning a DNA Sequence with a Protein Sequence

Name: Gene Myers, Sanford Selznick, Zheng Zhang, Webb Miller
Title: Progressive Multiple Alignment wtih Constraints

Name: Ken Dill, Andrew T. Phillips, J. Ben Rosen
Title: Protein Structure Prediction and Potential Energy Landscape Analysis 
       using Continuous Global Minimization 

Name: Alberto Caprara
Title: Sorting by Reversals is Difficult

Name: J. Richard Bradley, Steven Skiena
Title: Fabricating Arrays of Strings

Name: Simon Heath
Title: The application of Markov Monte Carlo methods to radiation hybrid mapping

Name: Tatsuya Akutsu, Satoru Miyano
Title: On the Approximation of Protein Threading

Name: Eric L. Anson, Gene Myers
Title: ReAligner: A Program for Refining DNA Sequence Multi-Alignments

Name: George A. Komatsoulis, Michael Waterman
Title: Chimeric alignment by dynamic programing: Algorithm and biological uses

Name: Gary A. Churchill
Title: Monte Carlo Sequence Alignment

Name: Benno Schwikoski, Martin Vingron
Title: The Deferred Path Heuristic for the Generalized Tree Alignment Problem

Name: Tao Jiang, Richard M. Karp
Title: Mapping Clones with a Given Ordering or Interleaving

Name:  Jamie Cohen, Martin Farach
Title: Numerical Taxonomy on Data: Experimental Results

Name: Dan Fasulo, Tao Jiang, Richard M. Karp, R. Settergren, E. C. Thayer
Title: An Algorithmic Approach to Multiple Complete Digest Mapping

Name: Sing-Hoi Sze, Pavel Pevzner
Title: Towards 100% Accurate Gene Recognition: Suboptimal and Error-Tolerant
       Spliced Alignment

Name:   Ralf Zimmer, Tom Lengauer
Title:  Fast and Numerically Stable Parametric Alignment of Biosequences

Name: Tao Jiang, Lusheng Wang, Dan Gusfield
Title: A More Efficient Approximation Scheme for Tree Alignment 

Name: Serafim Batzogloa, Scott E. Decatur 
Title:  Constant Approximation Algorithm on the Triangular Lattice and
        Generalized Hydrophobicity for Protein Folding in the
        Hydrophobic-Polar Model

Name: S. Muthukrishnan, Laxmi Parida
Title: A highly effective simple combinatorial approach for constructing
       physical maps by optical mapping 

Name:  Richa Agarwala, V. Dancik, S. Hannenhalli, M. Farach,
       S. Muthukrishnan, S. Skiena
Title: Local Rules for Protein Folding on a Triangular Lattice 

Name: K. Reinert, Hans-Peter Lenhof, P. Mutzel, K. Mehlhorn, J. D. Kececioglu
Title: A Branch-and-Cut Algorithm for Multiple Sequence Alignment

Name:  Hans-Peter Lenhof
Title:  New Contact Measures for the Protein Docking Problem 

Name: Haim Kaplan, Ron Shamir, Robert Tarjan
Title: Faster and Simpler Algorithm for Sorting Signed Permutations by Reversals

Name:  Ying Xu, Edward Uberbacher
Title:  Reference-based Gene Model Prediction on DNA Contigs

Name:  B. DasGupta, T. Jiang, S. Kannan, M. Li, Z. Sweekyk
Title: On the Complexity and Approximation of Syntenic Distance 

Name:  Mutida Jain, Gene Myers
Title:  Algorithm for Computing and Integrating Physical Maps Using Unique
        Probes

Name:  Gary Benson 
Title:   Sequence Alignment with Tandem Duplication

Name: Hiroshi Mamitsuka 
Title: Supervised Learning of Hidden Markov Models for Sequence Discrimination 

Name:   William Hart
Title:  On the Computational Complexity of Sequence Design Problems

Name:  William Hart, Sorin Istrail
Title:  Lattice and Off-Lattice Side Chain Models of Protein Folding:
        Linear Time Structure Prediction Better than 86\% of Optimal

Name: David Greenberg, Cynthia Phillips, David Wilson
Title:   Beyond Islands: Ambiguity in Random Clone-Probe Matrices

Name: David Sankoff, V. Ferretti, Joe Nadeau
Title: Conserved segment identification

Name:  John Kececioglu, T. Christof, M. J\"unger, P. Mutzel, G. Reinelt
Title:  A branch-and-cut approach to physical mapping with end-probes 

Name:  Donna Slonim, L. Kruglyak, L. Stein, Eric Lander
Title: Building Human Genome Maps with Radiation Hybrids

Name:   Bonnie Berger, Mona Singh
Title:  An Iterative Method for Improved Protein Structural Motif Recognition

Name:  Fengzhu Sun, Gary Benson, Mike Waterman
Title:  Pooling Strategies for Establishing Physical Genome Maps
        Using FISH

Name:  M. Ogihara, A. Ray
Title:  Simulating Boolean circuits on a DNA computer 

Name:  M. G. Reese, F. H. Eeckman, D. Kulp, D. Haussler
Title:  Improved Splice Site Detection in Genie

Name: Amir Ben-Dor, Benny Chor
Title: On Constructing Hybrid Maps

Name: Shili Lin, Terence P. Speed
Title: An Algorithm for Haplotype Analysis

Name: Tetsuo Shibuya, Hiroshi Imai
Title: New Flexible Approaches for Multiple Sequence Alignment

Name: Erich Bornberg-Bauer
Title: Chain Growth Algorithms for HP-Type Lattice Proteins

Name: W Cai, Anne Condon, RM Corn, E Glasser, Z. Fei, T. Frutos, 
Z. Guo, MG Lagally, Q Lui, LM Smith, A Theil
Title: The Power of Surfaced-based DNA Computation



-----------------------------------------


   See you in Santa Fe,

    Mike Waterman, Pavel Pevzner and Sorin Istrail




