From BIOSCI-REQUEST Tue May 6 23:06:00 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id XAA14988; Tue, 6 May 1997 23:06:00 -0700 Received: from gatekeeper.oss.akzonobel.nl (gatekeeper.oss.akzonobel.nl [192.87.3.2]) by net.bio.net (8.6.12/8.6.6) with ESMTP id XAA14985; Tue, 6 May 1997 23:05:58 -0700 Received: (from mail@localhost) by gatekeeper.oss.akzonobel.nl (8.7.5/8.7.3) id IAA28477 for ; Wed, 7 May 1997 08:14:33 +0200 (MET DST) Received: from unknown(145.49.94.105) by gatekeeper.oss.akzonobel.nl via smap (V2.0alpha) id xma029375; Wed, 7 May 97 08:13:25 +0200 Message-ID: <33709A61.50D5@am.otbc01.umc.akzonobel.nl> Date: Wed, 07 May 1997 08:06:09 -0700 From: Bob van Gemen Reply-To: bvgemen@am.otbc01.umc.akzonobel.nl Organization: Organon Teknika X-Mailer: Mozilla 3.0 (Win16; I) MIME-Version: 1.0 To: rna@net.bio.net Subject: RNase H digestion of RNA Content-Type: text/plain; charset=us-ascii Content-Transfer-Encoding: 7bit Dear RNA researchers, Part of the NASBA nucleic acid amplification technology that is investigated in my lab is the degradation of RNA by RNase H (both the E. coli enzyme and AMV-RT) in a DNA::RNA hybrid. Does anyone know if there are preferred recognition sites and/or cutting sites for these enzymes in the RNA sequence? Some of our preliminary work suggests that there might be such sites. Any information on the subject will be appreciated. From BIOSCI-REQUEST Fri May 9 02:00:16 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id CAA18927; Fri, 9 May 1997 02:00:16 -0700 Received: (from biohelp@localhost) by net.bio.net (8.6.12/8.6.6) id CAA18906; Fri, 9 May 1997 02:00:10 -0700 Date: Fri, 9 May 1997 02:00:10 -0700 From: BIOSCI Administrator Message-Id: <199705090900.CAA18906@net.bio.net> To: rna@net.bio.net Subject: BIOSCI/bionet miniFAQ & Fundraiser (LAST REVISION: 30-JUL-95) This BIOSCI "miniFAQ" is designed to answer the questions that come up the *most frequently*. The main BIOSCI FAQ (Frequently Asked Questions) is accessible on the World Wide Web at URL http://www.bio.net/. If you can not find an answer to your question in this or other documentation, the BIOSCI technical support staff answers e-mail queries sent to biosci-help@net.bio.net We can only answer questions about the use of the newsgroups and mailing lists. We unfortunately do not have the staff to do Internet information searches or answer scientific questions. Please post those to the appropriate BIOSCI/bionet newsgroups. Contents: -------- 0) BIOSCI NEEDS YOUR SUPPORT!! 1) Using the WWW to access the BIOSCI/bionet newsgroups. 2) What to do about "spams," i.e., junk mail, ads, etc. 3) Examples of subscribing and unsubscribing to the mailing lists. 4) The BIOSCI user address and research interest directory. 0) BIOSCI NEEDS YOUR SUPPORT!! ------------------------------ BIOSCI's government funding has been expended, and we are now operating solely from advertising revenue that we have raised from our Web site at http://www.bio.net/. We need just a few minutes of your time to help us serve you. You can do two important things which will take very little time for you individually and will immensely help us continue to help you. First, please use our WWW system at http://www.bio.net/ to access the archives. You can post or reply to messages via your Web browser as described in item #1 below. Your usage helps attract sponsors. If you contact any of our sponsors, please be sure to thank them for supporting BIOSCI. It is critical for them to get this feedback if they are to continue their sponsorship for the long term. Second, if you work for a company or organization that provides products or services of interest to the biology community, please pass this message on to your marketing or marketing communications department or other appropriate group. Please ask them to help support BIOSCI by sponsoring our Web site and explain the uses and benefits of the system to the biology community. If they are interested, they can then contact us for further information at our tech support address, biosci-help@net.bio.net. 1) Using the WWW to access the BIOSCI/bionet newsgroups. -------------------------------------------------------- As of 10 December 1995, all BIOSCI/bionet full newsgroups are accessible through the World Wide Web (WWW) at URL http://www.bio.net. One can read and reply publicly or privately to both recent postings and archived messages through one's Web browser if it is configured properly to send e-mail. Each newsgroup is equipped with its own WAIS index. The main BIOSCI home page also has access to the BIO-JOURNALS Table of Contents database WAIS index and the BIOSCI user address database described in another item further below. 2) What to do about "spams," i.e., junk mail, ads, etc. ------------------------------------------------------- BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups), mailing lists, and a hypermail archive at URL http://www.bio.net/. The same postings are distributed on all media (except for a small number of mailing-list-only groups at net.bio.net). Unfortunately it is becoming a despicable practice on the Internet (by a few people out to make a fast buck) to do automated mass postings to thousands of newsgroups and mailing lists. These attempts to grab free advertising are refered to as "spams" in the usual, somewhat boneheaded, net terminology. USENET is more susceptible to this practice, and many spams originate on the USENET groups and then are passed on to the mailing lists. However, spammers also get lists of mailing addresses and hit these too, so neither medium is immune. What should you do personally if you get junk mail? --------------------------------------------------- Just delete it and move on without reading it further. Filing a protest is becoming increasingly useless because spammers are often disguising the addresses where the messages are sent from. Unless you really understand Internet mail systems, your attempt at protest by sending replies to the message will often end up being sent to the address of an innocent person that the spammer is victimizing. What can BIOSCI/bionet do to protect its newsgroups? ---------------------------------------------------- The only solution currently available is to moderate the newsgroup. If this newsgroup is already moderated, then you are in good shape. Moderation protects the USENET distribution from about 95% of the spams that are being sent to date and protects the mailing lists completely. Moderation means, however, that someone has to take the time to review each message before it goes out. We have set up software here that simply allows the moderator to forward to an address at net.bio.net messages that (s)he wishes to have distributed. This takes no more time than that needed to read the message and pass it on, say about 1 min. per message. Most newsgroups currently have a discussion leader who is responsible for their newsgroup. The discussions leaders and their e-mail addresses are listed in the BIOSCI Information Sheet which is available on the Web at http://www.bio.net/. If a newsgroup is being hit with too many junk postings, please contact the discussion leader for that group and see if there is interest in moderating the group. Please do not assume that by simply posting a complaint to the newsgroup itself, anyone on the BIOSCI staff will act on your complaint. With close to 100 newsgroups to run, the BIOSCI staff has to rely on the discussion leaders of each newsgroup to report problems directly to us at biosci-help@net.bio.net. We will moderate any of our newsgroups if the discussion leader tells us that the readership of the group wishes to do so and if a moderator is willing to do the work. For most BIOSCI/bionet groups, this entails only a few minutes of work each day. Moderating a newsgroup will resolve probably 95% of the junk postings on the USENET distribution. Unfortunately there are easy ways for determined spammers to override the moderation mechanism on USENET, but we can protect our e-mail subscribers from unwanted postings if the newsgroup is moderated. You can also access our newsgroups over the WWW at URL http://www.bio.net. While this Web interface will not stop spammers from trying to post to the groups, this will give you yet another way, besides using USENET news, to keep the junk out of your personal mail files. For those of you with local USENET news systems, the Web interface will also give you faster access to new newsgroups and recent postings. 3) Examples of subscribing and unsubscribing to the mailing lists. ------------------------------------------------------------------ PLEASE NOTE: The BIOSCI management does NOT act on subscription/unsubscription requests that are posted improperly to the newsgroups and mailing lists. People who do this only bother everyone on the lists to no avail. Please be sure to follow the proper procedures below. Gory details are in the BIOSCI Information sheets on the Web at http://www.bio.net. Below we give an example utilizing the METHODS-AND-REAGENTS list at both of our two BIOSCI sites: Users in the Americas and Pacific Rim countries who use the BIOSCI ------------------------------------------------------------------ node at computer net.bio.net: ---------------------------- A) Determine the "listname" which is the <=8 character mail address ^^^^^^^^^^^^^ for the group. These can be found in the BIOSCI Info. Sheet. For the METHODS-AND-REAGENTS group the mailing address is methods@net.bio.net. The listname is the portion of the address to the left of the @ sign, i.e., "methods". The listname is used with the "subscribe" and "unsubscribe" commands illustrated below. B) Mail all commands in the body of a mail message addressed to biosci-server@net.bio.net. Do NOT send commands to the newsgroup posting addresses! Leave the Subject: line blank, any text on it will be ignored. C) In the body of your message put one or more of the following commands with an "end" command on the last line, e.g., subscribe methods unsubscribe methods end Do NOT put your e-mail address or other text on these lines. The server only allows you to cancel your subscription if the address on your mail header matches the address on our mailing list. Please ask for help at biosci-help@net.bio.net if your address has changed, e.g., if you know you are on the list but the server tells you that you are not a member. Users in Europe, Africa, and Central Asia who use the BIOSCI node at -------------------------------------------------------------------- computer daresbury.ac.uk (also known as dl.ac.uk): ------------------------------------------------- To subscribe and unsubscribe to/from the BIOSCI lists, you need to specify the full USENET newsgroup name with "bionet-news." prepended. The USENET newsgroup names are listed in the BIOSCI Information sheet on the Web at http://www.bio.net/. For the METHODS-AND-REAGENTS list the USENET newsgroup name is bionet.molbio.methds-reagnts, thus the appropriate commands are sub bionet-news.bionet.molbio.methds-reagnts unsub bionet-news.bionet.molbio.methds-reagnts These commands are included in a message addressed to mxt@dl.ac.uk, NOT to the newsgroup mailing addresses. As usual, include the text in the body of the message as text on the Subject: line is ignored. To unsubscribe from all the lists at the UK node, use unsub bionet-news Please note that if the address in the list is different than the one in your mail message header, you will not be able to unsubscribe by this method. If you have problems, please mail biosci@daresbury.ac.uk. 4) The BIOSCI user address and research interest directory. ----------------------------------------------------------- Please take this opportunity to add your name, address, and research interest information to the BIOSCI User Address Database if you have not already done so. You can fill out the address form directly through our Web page at URL http://www.bio.net/adrform.html. The address database is reindexed nightly for WWW access (the URL is http://www.bio.net/). If you are not directly on the Internet but can reach it by e-mail, please use our waismail server to access the user directory. waismail use is described above. You can also request a user address form by e-mail from biosci-help@net.bio.net. Please check your database entry from time-to-time to see if your address information is still up-to-date. Because of our limited personnel resources, we ask that you resubmit a *complete* form to revise your entry; we only replace complete entries and do not have resources to edit old forms. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From BIOSCI-REQUEST Tue May 13 15:18:43 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id PAA20373; Tue, 13 May 1997 15:18:43 -0700 Received: from research-01.ski.mskcc.org (research-01.ski.mskcc.org [140.163.96.254]) by net.bio.net (8.6.12/8.6.6) with ESMTP id PAA20370; Tue, 13 May 1997 15:18:41 -0700 Received: from ski.mskcc.org ([140.163.95.165]) by research-01.ski.mskcc.org (Netscape Mail Server v2.02) with SMTP id AAA11616 for ; Tue, 13 May 1997 18:17:36 -0400 X-Mailer: Microsoft Internet Mail and News for Macintosh - 1.1 (34) Subject: post doc From: h-furneaux@ski.mskcc.org (Furneaux Henry) To: rna@net.bio.net Mime-version: 1.0 Content-type: text/plain; charset="us-ascii" Date: Tue, 13 May 1997 18:17:36 -0400 Message-ID: <19970513221736.AAA11616@ski.mskcc.org> *********** POSTDOCTORAL RESEARCH OPPORTUNITY *********** may 13 1997 A postdoctoral research position is available immediately to study the regulation of gene expression by the Elav-like mRNA binding proteins . Applicants with a significant background in Biochemistry or Molecular Biology are encouraged to apply. Applicants must be U.S. citizens or permanent residents . Salary commensurate with experience; medical benefits and affordable housing included. Send C.V. and two letters of reference by email only. From BIOSCI-REQUEST Wed May 21 21:08:05 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id VAA05229; Wed, 21 May 1997 21:08:05 -0700 Received: (from kristoff@localhost) by net.bio.net (8.6.12/8.6.6) id VAA05157; Wed, 21 May 1997 21:07:42 -0700 Date: Wed, 21 May 1997 21:07:42 -0700 From: David Kristofferson Message-Id: <199705220407.VAA05157@net.bio.net> To: rna Subject: IMPORTANT - BIOSCI moving to Stanford! After more than a decade of serving the biology community on the BIOSCI project, I have decided that it is time for me to pass the torch. The demands of my career and family are making it increasingly difficult for me to run BIOSCI adequately on a part-time basis, and I've decided that I would do the project more harm than good by clinging to it. Therefore I have concluded an agreement with the Stanford University Libraries to take over the management of the BIOSCI project effective 6 June 1997. Many of you know the work of the Stanford Libraries through HighWire Press which has done an excellent job bringing the Journal of Biological Chemistry, Science Magazine, and other prestigious journals to the WWW (see http://highwire.stanford.edu/). I have every confidence that Stanford will provide an environment where the BIOSCI project can flourish. The BIOSCI team at Daresbury will continue to support the project in Europe, and Dave Mack and Julie Lawrence on the current BIOSCI staff will continue to assist the new team at Stanford. The project will be managed by Serge Taylor of the Stanford Libraries who is responsible for developing Web-based "knowledge environments" for scientists. I will still participate with the project in an advisory capacity but have to phase myself out of day-to-day operations. Many of you who read bionet.announce, bionet.biology.computational, and bionet.jobs.offered (the groups that I moderate) have been aware of the recent posting delays that my busy schedule has inflicted on those newsgroups. I am pleased to announce that Todd McGee, Scientific Advisor of the HighWire Press, will be taking over moderation of those groups from me this week. ** NOTE ** - The BIOSCI hardware will be down for backups on 6 June and will be moved over the weekend of June 7 and 8. We will be changing the IP number of the machine, but the host name and all mailing addresses will remain unchanged. There may be a few days of service disruption during this time due to the move unfortunately, just as we experienced in BIOSCI's previous move. We hope to keep this to a minimum. We will post status reports on the move to bionet.announce before and after it happens. Please watch that newsgroup for details. It has been a pleasure serving all of you since the "early days" of biology on the Internet. I've had the pleasure of not only "knowing" many of you over the Internet, but have also met literally thousands of biologists around the U.S. and elsewhere during the many Internet training seminars that I gave over the last decade. I've been truly fortunate to have been given the chance to play a role in the growth of biology on the Internet. This is something I will always treasure. Sincerely, Dave Kristofferson BIOSCI/bionet Manager biosci-help@net.bio.net From BIOSCI-REQUEST Tue May 27 08:45:26 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id IAA20442; Tue, 27 May 1997 08:45:26 -0700 Received: from darius.nas.edu (darius.nas.edu [144.171.1.12]) by net.bio.net (8.6.12/8.6.6) with ESMTP id IAA19735 Received: from nas.edu (chariot.nas.edu [144.171.1.14]) by darius.nas.edu (8.8.5/8.7.3) with SMTP id LAA18725; Tue, 27 May 1997 11:46:44 -0400 (EDT) Received: from cc:Mail by nas.edu id AA864758424; Tue, 27 May 97 11:37:00 EST Date: Tue, 27 May 97 11:37:00 EST From: "Barbara Wright" Encoding: 410 Text Message-Id: <9704278647.AA864758424@nas.edu> To: aibslist@net.bio.net, ascb@net.bio.net, autoseq@net.bio.net, bio-info@net.bio.net, bio-jrnl@net.bio.net, bio-soft@bet.net.net, bio-www@net.bio.net, biochrom@net.bio.net, bioforum@net.bio.net, bionews@net.bio.net, biophys@net.bio.net, cellbiol@net.bio.net, comp-bio@net.bio.net, csm@net.bio.net, ecophys@net.bio.net, emf-bio@net.bio.net, faseb@net.bio.net, gdb@net.bio.net, genbankb@net.bio.net, gnome-pr@net.bio.net, maize@net.bio.net, methods@net.bio.net, microbio@net.bio.net, molmodel@net.bio.net, neur-sci@net.bio.net, plant-ed@net.bio.net, pop-bio@net.bio.net, recom@net.bio.net, rna@net.bio.net, rust-mil@net.bio.net, str-nmr@net.bio.net, symbios@net.bio.net, toxicol@net.bio.net, ascb@net.bio.net, info-gcg@net.bio.net Cc: rumble@enh.nist.gov, puhlir@nas.edu Subject: 1997 National Data Conference CONFERENCE ANNOUNCEMENT The Conference on Scientific and Technical Data Exchange and Integration Sponsored by U.S. National Committee for CODATA National Research Council December 15-17, 1997 Natcher Conference Center National Institutes of Health Bethesda, MD The exchange of scientific and technical (S&T) data among different computing environments and across diverse scientific and engineering disciplines presents major problems that hinder full exploitation of computer-based modeling, the Internet, modern scientific databases, and new computer technology. The U.S. National Committee for CODATA is sponsoring the first major interdisciplinary conference on this subject on December 15-17, 1997, in Bethesda, MD. The conference has three main purposes: - To identify areas, with special emphasis on interdisciplinary needs, in which data exchange and integration are important; - To highlight major S&T data exchange and integration efforts already underway or in planning; and - To foster serious and significant cooperation in these kinds of activities among scientific and engineering disciplines, and governmental and non-governmental organizations. Extended Call for Papers The conference will consist of four types of sessions: plenary invited lectures; contributed papers (which will be presented as posters); demonstrations; and small discussion sections. Case studies are particularly encouraged. Contributed papers and demonstrations are invited on the following topics: Discipline-specific data exchange activities and requirements Interdisciplinary data exchange activities and requirements Federally supported data exchange programs Definitions of scientific and technical metadata issues The computer science of data exchange and integration The impact of the Internet and the World Wide Web on S&T data exchange and integration Future needs for data exchange and integration for scientific and technical data The contributed papers and demonstrations will play a major role in the conference by identifying existing activities and approaches that will provide direction and insight for further activities. All contributed papers will be considered for publication in the Conference proceedings, which will be published on the Internet soon after the Conference. A 200 word (maximum) abstract should be submitted (preferably by e-mail) by August 1, 1997 (new extended date) to: Paul F. Uhlir Director, U.S. National Committee for CODATA National Research Council 2101 Constitution Avenue, NW Washington, DC 20418 (202) 334-1684 (fax) (202) 334-2421 (tel.) codataco@nas.edu For further information, contact the U.S. National Committee for CODATA as provided above, or John Rumble, Conference Program Chair, National Institute of Standards and Technology, Building 820, Room 113, Gaithersburg, MD 20899, e-mail john.rumble@nist.gov, telephone (301) 975-2200. Notification of acceptance will be given by August 15, 1997. Conference Sponsors Defense Technical Information Center Department of Energy National Aeronautics and Space Administration National Institutes of Health National Institute of Standards and Technology National Oceanic and Atmospheric Administration National Science Foundation [Additional sponsors to be added] Preliminary Program Monday, December 15, 1997 8:40 Welcome Chair, U.S. National Committee for CODATA 8:45 Conference Introduction William Wulf, National Academy of Engineering (Accepted) Plenary Session 1 - The Importance of Scientific Data Sharing 9:00 Sharing scientific data - A key to progress in research and development Rita Colwell, University of Maryland Biotechnology Institute (Accepted) 9:30 Getting more from our research investment - Cross-discipline research and information sharing Neal Lane, National Science Foundation (Accepted) 10:00 Data exchange and integration - Fundamental issues John Rumble, National Institute of Standards and Technology (Accepted) 10:30 Coffee 10:50 Industry using information - Why industry shares scientific and technical data, and how Robert Kiggans, PDES, Inc. (Accepted) 11:20 The need for data sharing in global change research Robert Corell, National Science Foundation (Accepted) 11:50 Lunch Demonstrations and Poster Presentations (from 11:45 am on Monday until 5:00 pm on Tuesday) Plenary Session 2 - Tearing Down the Walls: The Art and Science of Data Exchange and Integration 3:00 Data exchange and integration - Approaches Gio Wiederhold, Stanford University (Accepted) 3:30 Information modeling Yuhwei Yang, Product Data Integration Technology (Accepted) 4:00 Resolving conceptual disagreements 4:30 The sociology of data exchange - Reaching consensus on data exchange tools Bruce Wiersma, University of Maine at Orono (Accepted) 5:00 Making data easy to share Ben Shneiderman, University of Maryland (Accepted) 5:30 Adjourn Tuesday, December 16 Plenary Session 3: Challenges to Cooperation - Why data exchange must succeed 9:00 Sharing scientific and technical data - Maximizing the potential of the National Information Infrastructure Senior Administration Official [to be determined] 9:45 Long-term ecological and environmental data - The challenge of keeping and remembering Susan Stafford, Oregon State University (Accepted) 10:10 Space observation data - Looking in and looking out Jim Green, NASA (Accepted) 10:35 Coffee 11:00 Human health and global climate change Paul Epstein, Harvard University (Accepted) 11:25 Geographic information systems - what everybody needs, and why David Mark, University of Buffalo (Accepted) 11:50 Molecular and cellular bioinformatics - From molecules to biological functionality David Lipman, National Center for Biotechnology Information (Accepted) 12:15 Lunch Break Out Sessions 1:15 Break out sessions - topics to be finalized later 2:45 Coffee 4:45 Conclusion of break out sessions Plenary Session 3 - Challenges of Cooperation (cont.) 5:00 Sharing social science data Roberta Miller, Consortium for International Earth Science Information Network (Accepted) 5:30 Adjourn Wednesday, December 17 Plenary Session 4 - How to Cooperate - Examples of Successful Cross-Discipline Data Exchange and Integration 8:45 Geographic information systems John Moeller, U.S. Geological Survey and Federal Geographic Data Committee (Accepted) 9:05 ISO Standard for the exchange of product data Howard Bloom, National Institute of Standards and Technology (Accepted) 9:25 World Data Centers Ferris Webster, University of Delaware (Accepted) 9:45 To be determined 10:05 Coffee Closing Plenary 10:30 Ideas from the Break-Out Sessions Julian Humphries, Kansas State University (Accepted) 10:50 Next steps for the scientists Robert Robbins, Fred Hutchinson Cancer Research Center (Accepted) 11:20 Next steps for the research community Official from the Office of Science and Technology Policy [TBD] 11:45 Final Remarks Chair, U.S. National Committee for CODATA Additional Background By data exchange is meant several things: the transfer of large amounts of data from one set of software to other software; extracting small amounts of data from one or more data sources for specific use; and the creation of a linked or integrated data system with multiple data sources. Other possibilities exist. Data exchange has two major components: the stream of bits and bytes that actually represent the data items and fields, and the contextual meaning of individual data items and fields. S&T disciplines and applications have begun addressing data exchange issues, but progress has been slow and difficult for a variety of reasons. Scientists are often not accustomed to formal standards. Discipline experts, even though they may be quite knowledgeable in computation and database management, frequently lack expertise in information modeling and exchange standards. Metadata are not well defined, complicating the application of data across diverse scientific areas. As a result, interdisciplinary data exchange has been difficult to promote and rarely implemented. Consider for a moment geographic information. Many applications need such information: to locate physically the sources of samples, to describe the range of a phenomenon, or to specify the location of an event, among others. Today many geographic information systems serve diverse communities of users, and several efforts to develop standards for exchanging data among these systems have been proposed. Yet progress to develop such standards in other areas has been slow. Other types of scientific data, such as biological nomenclature, chemical and engineering material identification and temporal data, suffer the same problem. Many uses for these data exist outside the scientific disciplines that generate them, yet accepted methods for exchanging these data remain elusive. In Finding the Forest in the Trees, The Challenge of Combining Diverse Environmental Data, the U.S. National Committee for CODATA clearly documented case studies in which data interfacing, defined in that report as the coordination, combination or integration of data for the purpose of modeling, correlation, pattern analysis, hypotheses testing, and field investigation at various scales, was necessary to achieve full value of research investment. Data interfacing is founded upon the standards and protocols agreed to by different scientific disciplines to exchange data. Particular emphasis must be put on the role of metadata in this data exchange. About CODATA The Committee on Data for Science and Technology (CODATA) is an interdisciplinary committee organized under the International Council of Scientific Unions (ICSU). CODATA is concerned with all types of quantitative data resulting from experimental measurements or observations in the physical, biological, geological, and astronomical sciences. Particular emphasis is given to data management problems common to different scientific disciplines and to data used outside the field in which they were generated. The general objectives are the improvement of the quality and accessibility of data, as well as the methods by which data are acquired, managed, and analyzed; the facilitation of international cooperation among those collecting, organizing, and using data; and the promotion of an increased awareness in the scientific and technical community of the importance of these activities. The U.S. National Committee for CODATA is organized by the National Research Council to administer activities within the United States related to CODATA. The Committee is funded by several federal agencies. Over the past decade, the Committee has completed several studies that have identified and analyzed issues related to maximizing the availability and usability of scientific and technical data. This national conference builds upon those studies and is intended to spur further progress and cooperation in data exchange and integration. Local Information The Natcher Conference Center is located in the National Institutes of Health complex in Bethesda, MD at 45 Center Drive. It is most easily accessible by the Metro or by taxi. Parking facilities are limited. A block of rooms has been reserved at the government rate at the Bethesda Hyatt Regency Hotel, 1 Bethesda Metro Center (on Wisconsin Avenue), tel. (301) 657-1234. The hotel is located by the Bethesda Metro stop on the Red Line, one stop from the Natcher Conference Center. Additional information about the Conference site, hotel accommodations, and local travel will be provided to all registrants in advance of the meeting. Organizing Committee Goetz Oertel (Chair), Association of Universities for Research in Astronomy Gerald Barton, National Oceanic and Atmospheric Administration James Beach, National Science Foundation W. Murray Black, George Mason University Rita Colwell, Maryland Biotechnology Institute Ali Ghovanlou, Department of Energy Sara Graves, University of Alabama at Huntsville Micah Krichevsky, Bionomics International David Lide, Jr., Chair, U.S. National Committee for CODATA, and consultant Kurt Molholm, Defense Technical Information Center John Rumble, National Institute of Standards and Technology James Thieman, National Aeronautics and Space Administration Paul Uhlir, Director, U.S. National Committee for CODATA, National Research Council Program Committee John Rumble (Chair), National Institute of Standards and Technology Martin Hardwick, STEP Tools, Inc. Julian Humphries, University of Kansas Paul Kanciruk, Oak Ridge National Laboratory David Mark, National Center for Geographic Information and Analysis Crystal Newton, Materials Sciences Corporation Robert Robbins, Fred Hutchinson Cancer Research Center Gio Wiederhold, Stanford University Conference Registration Space is limited and advance registration is required. To register, please complete the form (below), detach, and mail, enclosing a non-refundable registration fee. Registration fee: Before November 15, 1997 $150.00 After November 15, 1997 $200.00 Students $ 30.00 Please send only one registration per form. For other participants, reproduce the form prior to completing it. Only checks, money orders, or purchase orders can be accepted. We regret that we cannot take reservations by email and that we cannot accept credit cards. If you have special dietary or physical needs, please notify us in writing when registering. Need more information? Call: (202) 334-2421, or Email: CODATACO@NAS.EDU (Cut here) ......................................................................... ............................................ Registration for Conference on Scientific and Technical Data Exchange and Integration (One form per registrant only--please print or type) Full Name: Title: Affiliation: Mailing Address Street: City: State: Zip code: Country: Telephone: Electronic mail address: Please indicate below if you have any dietary or physical restrictions, or have other comments: Please make check payable to: U.S. National Committee for CODATA. Mail to: U.S. National Committee for CODATA National Research Council, Room 315 2101 Constitution Avenue, NW Washington, DC 20418 From BIOSCI-REQUEST Tue May 27 11:22:23 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id LAA22867; Tue, 27 May 1997 11:22:23 -0700 Received: from darius.nas.edu (darius.nas.edu [144.171.1.12]) by net.bio.net (8.6.12/8.6.6) with ESMTP id LAA22796 Received: from nas.edu (chariot.nas.edu [144.171.1.14]) by darius.nas.edu (8.8.5/8.7.3) with SMTP id OAA25702; Tue, 27 May 1997 14:25:34 -0400 (EDT) Received: from cc:Mail by nas.edu id AA864767952; Tue, 27 May 97 14:16:00 EST Date: Tue, 27 May 97 14:16:00 EST From: "Barbara Wright" Encoding: 15 Text Message-Id: <9704278647.AA864767952@nas.edu> To: To:aibslist@net.bio.net, autoseq@net.bio.net, bio-info@net.bio.net, bio-jrnl@net.bio.net, bio-soft@bet.net.net, bio-www@net.bio.net, biochrom@net.bio.net, bioforum@net.bio.net, bionews@net.bio.net, biophys@net.bio.net, cellbiol@net.bio.net, comp-bio@net.bio.net, csm@net.bio.net, ecophys@net.bio.net, emf-bio@net.bio.net, faseb@net.bio.net, gdb@net.bio.net, genbankb@net.bio.net, gnome-pr@net.bio.net, maize@net.bio.net, methods@net.bio.net, microbio@net.bio.net, molmodel@net.bio.net, neur-sci@net.bio.net, plant-ed@net.bio.net, pop-bio@net.bio.net, recom@net.bio.net, rna@net.bio.net, rust-mil@net.bio.net, str-nmr@net.bio.net, symbios@net.bio.net, toxicol@net.bio.net Subject: 1997 National Data Conference Below is an announcement we would like to include on your web site and/or include in the calendar section of your publication. It is a short version of the announcement forwarded to you earlier. Thank you. The U.S. National Committee for CODATA at the National Research Council in Washington, D.C., is sponsoring a National Conference on Scientific and Technical Data Exchange and Integration, December 15-17, 1997, at the National Institutes of Health in Bethesda, MD. Information about the conference, the call for papers, preliminary program, and registration may be obtained at the USNC/CODATA Web site at , or by email: codataconf@nas.edu From BIOSCI-REQUEST Tue May 27 12:18:29 1997 Return-Path: BIOSCI-REQUEST Received: (from daemon@localhost) by net.bio.net (8.6.12/8.6.6) id MAA03980; Tue, 27 May 1997 12:18:29 -0700 Received: from ummed.edu (ummed.edu [146.189.16.244]) by net.bio.net (8.6.12/8.6.6) with ESMTP id MAA03977; Tue, 27 May 1997 12:18:27 -0700 Received: from mxi.ummed.edu (mxi.ummed.edu [146.189.16.240]) by ummed.edu (8.6.12/8.6.12) with ESMTP id PAA07083 for ; Tue, 27 May 1997 15:19:21 -0400 Received: by mxi.ummed.edu (8.6.12/8.6.12) with SMTP id PAA15416 for ; Tue, 27 May 1997 15:19:20 -0400 Received: by banyan.ummed.edu; Tue, 27 May 97 15:19:17 EDT Date: Tue, 27 May 97 15:19:12 EDT Message-ID: X-Priority: 3 (Normal) To: From: (Ellen Kittler) Subject: post doc position available A POST-DOCTORAL POSITION IS AVAILABLE, funded for three years from 6/1/97, to study Transmembrane Protein Insertion Orientation in Yeast. Errors in insertion, folding, localization or processing of transmembrane (TM) proteins are responsible for numerous diseases including Alzheimer's disease, prion diseases and cystic fibrosis. Although the topogenic signals that determine Protein Insertion Orientation (PIO) are partially understood, the mechanism of response to these signals (the "PIO receptor") is unknown. Our goal is to identify the responsible cellular machinery by precise analysis of PIO signals in yeast cells and by the characterization of pio mutants specifically defective in responses to these signals. Analysis of variants of a model Type III TM protein demonstrates that the major PIO signal is the charge difference across the TM segment (Carol A. Harley and Donald J. Tipper. 1996. J. Biol Chem., 271: 24,625-24,633). This signal is imposed on a bias dependent on TM segment length and hydrophobicity. Analysis of this bias and of the effects of distance and polarity on the charged PIO signal should result in a refined rule for TM protein topology prediction. This will be applied to the yeast proteome database. Invertase fusions provide a powerful selection for pio mutants which allow partial inversion of PIO. Genetic analysis of the first of these mutants is in progress; we anticipate that cloning of PIO genes will identify PIO receptor components. CONTACT: Donald Tipper, MGM Dept, U. Mass. Medical School, Worcester, MA 01655. Phone, 508 856 2308. FAX, 508 856 5920. E mail, Donald.Tipper@ummed.edu. Address from 6/1/97 to 7/25/97, C/O Prof. Colin Hughes, Pathology Dept, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. POSTED FOR A FRIEND, reply directly to him .... or to me and I'll pass it along.