From owner-schistosoma@net.bio.net Mon Mar 01 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: Jean-Lou Justine <justine@cimrs1.mnhn.fr>
Newsgroups: bionet.organisms.schistosoma
Subject: Parasitology Course, 3-5 May 1999, Paris, France
Date: 2 Mar 1999 04:51:09 -0800
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Message already posted 28/01/99
-------------------------------

Parasitology Course, Paris, France,  May 3-5, 1999
"Evolution of Parasites and of Host-Parasite Relationships"

Programme of the course at the end of the message and:
http://www.mnhn.fr/ens/ed/07-justi.htm

List of courses organized in 1999 by the National Museum of Natural History
in Paris:
http://www.mnhn.fr/ens/ind_ed.htm

General information about the National Museum of Natural History in Paris:
http://www.mnhn.fr/index.html

----------------
The National Museum of Natural History in Paris, France organizes a series
of courses
on "Evolution of Parasites and of Host-Parasite Relationships". This course
is intended
for graduate and post-graduate students and all researchers in the field of
parasitology.
Registration is free of charge but participants should register in advance.
Most of the courses (8/9) will be given in French. Please refer to the
following information.

The present message also includes the list of conferences, and the form for
registration at the end.

For more details contact Pr Jean-Lou JUSTINE, e-mail: justine@mnhn.fr



        ----------------------------------------------------------
        "EVOLUTION DES PARASITES ET DES RELATIONS HOTES-PARASITES"
                            May 3-5, 1999
        ----------------------------------------------------------

Responsables: Dr Marie-Claude Durette-Desset et Pr Jean-Lou Justine
Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie
EP1790 CNRS "Biologie et Evolution des Parasites"
Museum National d'Histoire Naturelle, 61 rue Buffon, 75231 Paris cedex 05
Tel: (33) 1 40 79 35 03
Fax: (33) 1 40 79 34 99
E-mail: justine@mnhn.fr
----------------------


Informations generales:

Programme de ce cours:
http://www.mnhn.fr/ens/ed/07-justi.htm

Liste des cours organises par le Museum National d'Histoire Naturelle en 1999:
http://www.mnhn.fr/ens/ind_ed.htm

Site du Museum National d'Histoire Naturelle:
http://www.mnhn.fr/index.html

        Ce cours est organise pour la sixieme annee consecutive.
        Les cours sont destines a un public tres large de parasitologues
debutants
ou confirmes. Les personnes assistant aux Conferences peuvent obtenir une
"Attestation de Cours" a condition d'assister a la totalite des Conferences
et de rediger une courte synthese qui sera jugee par les organisateurs.
        Il n'y a pas de "resumes" des cours, mais les conferenciers preparent
des documents (schemas, textes) qui sont distribues gratuitement aux
participants.
        Une *excellente* connaissance de la langue francaise est necessaire
pour
assister a ce cours de maniere profitable. En 1999, 8 conferences seront en
francais, une en anglais.
        Malheureusement, rien n'est prevu pour le logement des participants.
Les hotels proches du Museum sont relativement chers (250-400 FF) mais il
existe
des hotels moins chers a Paris.
        L'inscription au cours est gratuite mais doit etre preferentiellement
effectuee a l'avance. Les formulaires sont disponibles sur simple demande.
        Les cours auront lieu au laboratoire de Chimie, 63 rue Buffon,
75005 Paris.

       ----------------------------------------------------------
                          PROGRAMME DU COURS
                        ======================
       "EVOLUTION DES PARASITES ET DES RELATIONS HOTES-PARASITES"
                            May 3-5, 1999
       ----------------------------------------------------------

Des petites modifications a ce programme sont encore possibles.

Lundi 3 mai 1999

	10h15-10h30	Accueil des participants
	10h30-12h00	Dr Andre THERON (Perpignan)
			Comportement, rencontre et evolution des systemes
Hotes-Parasites
	14h00-15h30	Pr Jean-Lou JUSTINE (Paris)
			Phylogenies des Plathelminthes
	15h45-17h15	Dr Tim LITTLEWOOD (Londres)
			Molecular systematics, phylogenetics and evolution
of parasitic Platyhelminthes

Mardi 4 mai 1999

	10h30-12h00	Dr Gaston PICHON (Bondy)
			Quantification et modelisation des relations hote/
vecteur/ parasite,
			principalement appliquees à la filariose de
Bancroft et au paludisme
	14h00-15h30	Pr Claude VAUCHER (Geneve)
			Présentation des Cestodes et originalite des
cestodoses humaines
	15h45-17h15	Dr Anders Pape MOLLER (Paris)
			Evolution de la virulence: theorie et tests empiriques

Mercredi 5 mai 1999

	10h30-12h00	Pr Jean-Claude BEAUCOURNU (Rennes)
			Diversite et strategies d'adaptation des Insectes
ectoparasites d'homeothermes
	14h00-15h30	Dr Christophe CHARTIER (Niort)
			Cas particulier des relations hotes-parasites: la
resistance des nematodes aux
			antihelminthiques chez les caprins
	15h45-17h15	Dr Marie-Claude DURETTE-DESSET (Montpellier)
			Rongeurs et Nematodes Trichostrongylina:
co-evolution ou capture?


Les cours auront lieu dans
La Salle de Cours Historique du Laboratoire de Chimie
Muséum National d'Histoire Naturelle, 63 rue Buffon
75005 Paris

Metro: Gare d'Austerlitz, Jussieu, Censier; Bus: Ligne 89



         ----------------------------------------------------------
                        BULLETIN D'INSCRIPTION
                        ======================
         "EVOLUTION DES PARASITES ET DES RELATIONS HOTES-PARASITES"
                            May 3-5, 1999
         ----------------------------------------------------------

 Responsables: Dr Marie-Claude Durette-Desset et Pr Jean-Lou Justine
 Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie
 EP1790 CNRS "Biologie et Evolution des Parasites"
 Museum National d'Histoire Naturelle, 61 rue Buffon, 75231 Paris cedex 05
 Tel: (33) 1 40 79 35 03
 Fax: (33) 1 40 79 34 99
 E-mail: justine@mnhn.fr
 ----------------------

Vous pouvez renvoyer ce bulletin d'inscription par e-mail, fax ou courrier.
Si vous renvoyez ce bulletin d'inscription par e-mail (methode conseillee):
- envoyez-la a l'adresse: justine@mnhn.fr
- avec sujet: "bulletin d'inscription rempli"
- renvoyez uniquement cette partie, PAS tout le message!


NOM:
Prénom:
Qualité:
        Etudiant DEA
        Etudiant Doctorat
                Annee de These
                Etablissement d'Inscription

        Fonction
                M.E.N.
                M.E.S.R.
                C.N.R.S.
                INSERM
                AUTRES

        Adresse professionelle:

        Adresse personnelle:

        Telephone:
        Fax:
        e-mail (TRES IMPORTANT):

Vous pouvez indiquer votre motivation ci-dessous (facultatif).

 -------------------------------------------------------------------
 Prof. Jean-Lou JUSTINE
 Laboratoire de Biologie parasitaire, Protistologie, Helminthologie
 CNRS EP 1790 "Biologie et Evolution des Parasites"
 Museum National d'Histoire Naturelle
 61 rue Buffon, 75231 PARIS cedex 05, France

 Telephone: France 01 40 79 35 03 International + (33 1) 40 79 35 03
 Fax:       France 01 40 79 34 99 International + (33 1) 40 79 34 99
 e-mail: justine@mnhn.fr       (Running 'Eudora' on a PPC Macintosh)

-------------------------------------------------------------------
 GRANTS from PARSYST programme
 (European Community TMR Programme "Access to Large Scale Facilities"
 Look at: http://www.mnhn.fr/progsc/index.html
 Conferences "Evolution of Parasites and Host-Parasite Relationships"
 Look at: http://www.mnhn.fr/ens/ed/07-justi.htm
 -------------------------------------------------------------------



From owner-schistosoma@net.bio.net Tue Mar 02 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: daemon@net.bio.net
Newsgroups: bionet.organisms.schistosoma
Subject: Molecular Parasitology Meeting
Date: 3 Mar 1999 02:56:43 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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10th Molecular Parasitology Meeting
***********************************

12-16 September 1999
Woods Hole, MA, USA.

Topics to be covered will include molecular biology, cell biology,
biochemistry and genetics of protozoan and helminth parasites.
Presentations (talks and posters) by graduate students and post-docs are
strongly encouraged.

Organizers: Christine Clayton (Heidelberg), Kasturi Haldar (Chicago), Buddy
Ullman (Portland, Oregon)

For information and on-line registration please
visit the Web site:        http://mpm.mbl.edu/

Alternatively contact Ms. L.-A. King, Marine Biological Laboratory, 7 MBL
Street, Woods Hole, MA 02543-1015, USA;  lking@hoh.mbl.edu

Registration deadline: May 15th 1999

PLEASE NOTE NEW E-MAIL ADDRESS!
cclayton@zmbh.uni-heidelberg.de

Christine Clayton
ZMBH
Im Neuenheimer Feld 282
D69120 Heidelberg
Germany

49-6221-546876
fax 49-6221-545894
e-mail:  cclayton@zmbh.uni-heidelberg.de
http://www.zmbh.uni-heidelberg.de


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From owner-schistosoma@net.bio.net Thu Mar 04 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: "K.R.Hata" <owner-tdr-scientists@who.ch>
Newsgroups: bionet.organisms.schistosoma
Subject: Dr Brundtland's speech at TDR's STAC
Date: 5 Mar 1999 02:32:19 -0800
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Dear TDR-scientists,

    Let me share with you a speech of Dr Brundtland at the opening of
    TDR's STAC meeting this week. It has just appeared at WHO's Web page.
    [http://www.who.int/inf-dg/speeches/english/hq_01031999.html]

                                Bob Hata
                                Host of tdr-scientists list

--

Dr Brundtland's speech at TDR's STAC
************************************

Dr. Gro Harlem Brundtland
Director-General
World Health Organization
                                                       WHO Headquarters,
                                                       1 March 1999



    21st Meeting of the Scientific and Technical Advisory Committee of
    the Special Programme for Research and Training in Tropical Diseases


Dear Members of the Scientific and Technical Advisory Committee,

It is a pleasure for me to welcome you to WHO at a time which combines
continuity and change.

Continuity, because so much of what WHO has been doing for the health of
so many is worth while pursuing. TDR is a prime example of this. It is
an example of world class expertise. It is an example of what the best
of partnerships can bring to the advancement of technology, medicines
and alleviation of suffering.

Change because the world around us is changing and because WHO as an
Organization needs to reposition itself to make a real difference for
global health.

We are changing to better focus our work, to get better synergies
between related activities, to forge closer relations with our Member
States, to devise more effective partnerships with others.

We are changing to better cope with a mandate which Member States tend
to increase, whereas the resources remain restricted.

We are changing because any organization needs to constantly work to
become better -- more effective -- more passionate.

Among your documents you will find a description of our new structure,
based on clusters. We have grouped the previous individual programmes
into nine clusters -- and then we have turned what used to be more than
50 programmes into 32 departments.

TDR is located at the heart of the Communicable Diseases Cluster.

The mission of the cluster is as simple as it is daunting: to reduce the
impact of communicable diseases worldwide by leading the global effort
in prevention, control, surveillance and research.

Its mandate is broad, ranging from monitoring the emergence of new,
sometimes unknown, diseases to the possible eradication of those against
which we have efficient tools and strategies. It is a major challenge.
Communicable diseases remain the most common cause of death in the
world. Of the 52 million deaths worldwide per year, an estimated
one-third are due to infectious diseases. And we have all the evidence
to say that the main burden of communicable disease is carried by the
poor. WHO -- committed to the cause of equity and the fight against
poverty -- has to maintain the fight against communicable diseases as a
key priority.

Of particular concern to us are the tropical diseases. Some call these
indigent diseases as they mainly affect the poor and do not get the
attention they deserve.

Our ambition is to do what we can to change that. The 24-year history of
TDR tells the story of how three international agencies, the World Bank,
the United Nations Development Programme, and WHO, jointly with other
loyal partners, have worked together to improve the health of those
affected by tropical diseases. TDR is rightly regarded as one of WHO's
success stories. You are a major player in that story. As TDR's highest
scientific committee, you have had a crucial role in keeping the
programme alive and dynamic, setting and updating its priorities and
direction.

TDR is indeed a special programme. Twenty-four years is no age. It is
still active and forward-looking, very relevant and, in fact, crucial,
to meet the challenges posed by tropical diseases.

All of these qualities will be needed, because there are major tasks
ahead.

Let us first review the current setting:

* WHO's reorganization has created an atmosphere that favours change,
  and we are fully committed to promote changes that will make a
  difference where it matters - the health conditions of disease endemic
  countries. Let us take advantage of this change process to strengthen
  the impact of our efforts also in TDR's area.

* TDR has undergone its 3rd External Review, which made suggestions on
  how to make this successful Programme even better. At the request of
  its Joint Coordinating Board, TDR is working on a new Strategic Plan
  with a long-term vision to guide the Programme in the next years,
  incorporating the suggestions of the External Review.

As you know, TDR has two basic goals:

1. Promote R & D for the development of new and improved tools to
   control tropical diseases.

2. Build research capacity of developing endemic countries through
   training and institutional strengthening.

Research and training for disease control - a simple, clear and relevant
mandate, is as needed and as valid today as it was 24 years ago.

We desperately need new and better tools, tools that are effective,
appropriate and affordable, and we desperately need to increase the
scientific capacity of the countries that suffer the toll of tropical
diseases.

Let me give you some examples. You know I have selected malaria and
tuberculosis as priorities among the communicable diseases. Since July
we have launched the Roll Back Malaria project and the Stop TB
Initiative.

* In relation to malaria, our target is to halve its burden through
  interventions adapted to local needs, and reinforcement of the health
  sector of the affected countries. This is a formidable task which will
  require concentrated efforts to radically improve the health systems
  of the poorest countries on earth - and to cope with the problem of
  increasing resistance to the available drugs.

* The situation is also very serious with regard to the spread of
  tuberculosis. Drug resistance is spreading, some countries are facing
  problems in relation to the implementation of the DOTS strategy, and
  the association of tuberculosis with HIV/AIDS is cause of great
  concern.

We could dramatically change the pattern if new tools became available.
For example, recent studies show us the impact new effective tools could
have on tuberculosis by the year 2030:

* a new vaccine with 50% efficacy could lower tuberculosis incidence by
  36 million cases and mortality by 9 million deaths;

* a single-contact treatment could avert 24 million cases and 11 million
  deaths;

* active case finding by using mass miniature radiography could save 23
  million lives

And let us at this stage only leave to our imagination the far-reaching
consequences of a good malaria vaccine.

All our knowledge is about the past -- but all our challenges lie in the
future. This is what stimulates researchers and scientists to make an
extra effort. So let us look briefly into that future.

We are again facing an old dilemma: Should we invest in dreams, such as
a malaria vaccine, or should we concentrate our resources on better use
of existing tools?

I want to reiterate once more: Research is essential. Decades ago a
polio vaccine was also just a dream, and the debate was raging between
those idealists who fought for it and those who wanted better iron lungs
and rocking beds to alleviate the intense suffering of polio victims. As
we approach polio eradication - made possible by the development of
effective oral vaccines - we forget how difficult the decision was to
keep investing in a dream that no one knew could become a reality.

Let us keep some of the dreams alive.

We definitely need new knowledge to fight tropical diseases. We need to
know our enemies better. These are:

* The pathogens that cause the diseases;

* The vectors that transmit them;

* The factors that undermine our defences against infection; and

* The environmental, social, economic and behavioural determinants that
  help disease propagation.

New knowledge, however, is not enough - we have to transform that
knowledge into tools for disease control. We need:

* new and improved drugs, vaccines and diagnostics that can be afforded
  by the poor;

* new and improved interventions, suitable for adoption by the health
  systems of poor countries;

* better methods for vector control that do not further exacerbate the
  environmental situation of our planet.

TDR will be 25 years old next year as we enter a new century -- a new
millennium. We will commemorate this Jubilee not only with festivities.
We will demand that TDR assume new duties, tasks, challenges and
responsibilities. To be very direct -- to assume more hard work.

TDR's new Strategic Plan, which will guide its future path, will be
presented in full to the Joint Coordinating Board this June. It will
focus on these new challenges and work with us in developing approaches
to undertake them. I count on you to carefully analyse the options
presented in the draft plan, discuss their implications and help TDR to
make the right choices. Among the options we are proposing is to expand
TDR's disease portfolio to include tuberculosis and dengue.

During this meeting, you will be presented with the reasons why we think
TDR must expand its mandate to include these two infectious diseases. To
me it is clear; carefully expanding the mandate means living up to TDR's
achievements. Carefully expanding the mandate means strengthening our
ability to make a difference.

We also need your help with another matter. Before I took office, I met
with the group of outside experts that conducted the Third External
Review. They told me that TDR has worked hard and effectively to
accomplish its mandate. And I know that it has done so using only
catalytic resources, or seed money.

TDR could do better, and more, if we could mobilise additional funds.

I am fully committed to do what I can to make this happen. In the long
run I can think of few more cost-effective investments in health.

* I do so when I ask our Member States not to adopt a budget which
  decreases our resources and pulls towards a downsizing of WHO and
  limited ability to deliver the work that the same Member States expect
  us to do.

* I will do so as we continue to raise money in the belief that WHO can
  merit a larger share of the voluntary contributions Member States and
  others are willing to commit to health and development.

* I will do so when I will continue our achievements of the last 8
  months and further rationalise the way we operate at Headquarters,
  Regional and country levels, to save precious resources and to
  redirect even more funds from administrative areas to our technical
  work.

Getting more funds and renewed support from Member States, donors and
other partners is of course our task - but you do have a share in the
effort and responsibility.

Your sound advice is crucial to TDR and the Communicable Diseases
cluster - and therefore to WHO. We are partners committed to better
world health. Your work, as TDR's top scientific experts, will impact on
the Programme's performance and that of WHO.

I am looking forward to receiving your advice. I wish you success in
your deliberations, and I wish TDR a bright future, as it approaches its
25 years of existence and as it looks ahead to new challenges and
opportunities into a new century.

Thank you.


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From owner-schistosoma@net.bio.net Thu Mar 04 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: rollin@writeme.com
Newsgroups: bionet.organisms.schistosoma
Subject: ISAAST '99
Date: 5 Mar 1999 01:04:09 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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             September 8-12, 1999  Beijing, China


Scientific Sessions
1. Biological Science
2. Clinical & Experimental Medicine
3. Health Care for the Elderly
4. Traditional Chinese Medicine in Aging & Antiaging

Exhibition
The companies engaged in producing the instruments or reagents that may
facilitate the antiaging researches are welcomed and encouraged to
exhibit
their high-tech products. For whose interested in the exhibition, please

contact us at your earliest convenience.

Sponsor
Antiaging Science & Technology Society£¬ Gerontological Society of China

Organizers
Antiaging Science & Technology Society , Gerontological Society of China

China International Symposium Center for Sciences and Technology
(CICCST)

Co-Organizer
BILONG Institute for Transgenic Animals in Beijing (BITAB)

Supporters
Gerontological Society of China
Institute of Medicinal Biotechnology,  Peking Union Medical College,
Chinese
 Academy of medical Sciences
Beijing Hospital and Gerontological Research Institute
(to be continued)

Contact:
*********************************************************
BILONG Academic Events
Add: 8 Nan Er Jie, Zhong Guan Cun, Beijing 100080, China
Box: P.O. Box 8734, Beijing 100080, China
Tel: 86-10-6256-0561, 6256-2226 Ext 211, 800-810-0797
Fax: 86-10-6253-2114
Email: BAE@bilong.com
*********************************************************



From owner-schistosoma@net.bio.net Mon Mar 15 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: VIAL Henri Symposium <symposia@crit.univ-montp2.fr>
Newsgroups: bionet.organisms.schistosoma
Subject: Symposium DRUGS AGAINST PARASITIC DISEASES, Montpellier, 2nd call
Date: 16 Mar 1999 04:50:11 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 398
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EUROPEAN UNION - DG XII, Cooperation with Third Countries INCO-DC program
COSTB9 , European Cooperation in the Field of Scientific and Technical
Research
WORLD HEALTH ORGANISATION,  Tropical Disease Research Programme


This is the second announcement (15/03/99) for an international symposium  on

-------------------------------------------------------------

	DRUGS AGAINST PARASITIC DISEASES
	24th to 26th May 1999, Montpellier, France

-------------------------------------------------------------

Practical information :
             		http://162.38.196.39/drug-symposium
			symposia@univ-montp2.fr
			Henri VIAL/ Christine BOUSQUET
			UMR 5539 CNRS/Université Montpellier II, cc107
			Place Eugène Bataillon
			34095 Montpellier cédex 5, France
			Tél. : (33) 4.67.14.42.87       Fax. : (33)
4.67.14.42.86

-------------------------------------------------------------
SCOPE OF THE MEETING

The meeting is being organized under the auspices of the European
Commission INCO-DC program, by the Tropical Diseases Research Branch of the
World Health rganisation and as the annual spring meeting of the European
Concerted Action on hemotherapy of Protozoal Infections (Cost action B9).
The symposium should offer pportunities for future collaborations and
discussions between these Institutions in such n important area. >This
meeting will provide experts in Parasitology, Biochemistry, cellular and
molcular Biology, Chemistry, Pharmacology, Toxicology, and research
managers with a forum in which to discuss advances and up-date their
knowledge concerning drug discovery in the area of parasitic diseases and
to provide facilities to accelerate drug evelopment in this crucial field,
and ways of improving control strategies. In addition, new research tools
are available such as genomics, genetic manipulaton. These represent
opportunities from basic research to the definition of operationa research.
Particularly, how to capitalise on information on the whole genome
approache of the parasite. What is the optimal utilisation of this
information ? Which of this biocheical pathways of these organisms can be
used for future drug development ?
We have invited prominent scientists and experts to present data on
up-to-date topics and would gladly welcome short communications or posters
you might have on the various topcs.
We hope hat this conference will strengthen the collaboration between
scientists, experts, an professionals both in the North and the South, thus
promoting excellence not only in resarch but also in practical
implementation.
------------------------------------------------------------
SCIENTIFC COMMITTEE
Croft, (London, UK)
Hagan (Glasgow, UK)
Horton (London, UK)
Kharazmi (Copenhagen, Denmark)
Lanzer (Heidelberg, D)
Perie (Toulouse, F)( Local Organizer)
Olliaro (Geneva, CH)
Opperdoes (Louvain, B)
Ridley (Geneva, CH)
Traore (INCO-DC, Brussels, and Mali)
Vial (Montpellier, F) (Local Organizer, Coordinator)
------------------------------------------------------------
RELIMINARY SCIENTIFIC PROGRAMME (15/03/99)
OPENING: GLOBAL PICTURE OF ANTIPARASITIC DRUGS  AND NEED IN CNTROL STRATEGIES
 Rob Ridley (WHO, Geneva, CH) : Parasitic disease: the need for new
approaches to tropical disease drug discovery and development for improved
control strategies.
 Patrice Trouiller (Grenoble, F) : Drug development output for tropical
diseases : what ae the economic constraints ?
>>SESSION I: HOW TO DISCOVER NOVEL PHARMACOLOGICAL TARGETS: THE PRASITE
>>GENOMES, WHAT DO THEY PROMISE AND WHAT ARE THE LMITATIONS ?
>>- Alister Craig (Oxford, UK) : The international programme on P.
>>falciparum genome squencing; status and  Post-Genomic Agenda.
> Sara Melville, (Cambridge, UK) : Organisation of the T. brucei genome
> David Parry Smith  (Cambridge, UK) : Overview of Bioinformatics and
>Applications in Dug Discovery
>-Pierre Casellas (SANOFI , Montpellier, F) : DNA chips: applications in
>pharmacology
>-Chris Gray (Hofmann La Roche, Basel, CH) : Bacterial Targets and
>Antibiotics: Gnome-Based Drug Discovery (Proteomics and application to
>pathogens).
>-Daniel Lawson (Sanger Center, Cambridge, UK) : Mechanistics of
>Bioinformartics.
>-xxx : Use of genetic engineering for demonstrating potential for Efficacy.
>>SESSION II: COMPOUNDS ACQUISITION AND SEQUENTIAL STEPS FROM THE BNCH TO
>>THE THRESHOLD OF PRECLINICAL STUDIES OR RATIONAL FOR DRUG DVELOPMENT
>>- J. Martinez (CNRS, Montpellier, F): Combinatorial chemistry: a new
>>challenge in dug discovery
> xxx    Natural sources.  Search for potential antimalarial from natural
>sources (plants). Ehnopharmacology , bioassay guided fractionation and
>structure elucidation.
> A. Fairlamb, (Dundee, Scotland) :   Trypanothione reductase and
>validation of this pathway as drug target by producing knock outs in
>leishmania.
> Micheal H. Gelb, (Seattle, USA)  Protein Prenylation in Trypanosomatids:
>A New "Piggy-Back" Medicinal Chemistry Target for Drug Development
> Paul Michels (Louvain, Belgium) : On the mathematical modelling of
>metabolic pathways and its use in the identification of the most suitable
>drug targets. (he has acepted)
> P. Olliaro (WHO, Geneva)  Rationale and Criteria for Drug combination.
>>SESSION III : METHODS FOR SCREENING OF POTENTIAL DRUGS. EVALUATION O
>>PHARMACOLOGICAL  ACTIVITIES.
>>- Simon Croft, (London, UK) In vitro and in vivo models for antiprotozoal
>>activity - prpose and relevance
>- Alan Thomas (BPRC, Rijswijk, NL) :  Models for the in vivo testing of
>potential compounds against  malaria.
>- J Julio Martin (Glaxo Wellcome, Madrid, Spain) : Screening methodologies
>for chemotherapeutic targets. High throughput screening as an essential
>complement to the genomic approach. Advanced technology to assist high
>throughput screening
>- Pascal Ringwald, (IRD, Yaoundé, Cameroon) : In vitro and in vivo
>chemosensitivity testing of the malaria parasites (where, who, how ...).
>Worlwide dynamic of resistance.
>- Pradipsinh Rathod, (University, Washington, USA) : Induction of
>resistance: when to ask this question and how to get an answer ?
>
>SESSION IV: PRE-DEVELOPMENT WORK: HOW TO GO THROUGH THE CLINICAL  STAGES.
>
>- Thomas Wellems (Bethesda, USA) : The molecular basis of chloroquine
>resistance
>- Hagai Ginsburg (Hebrew University of Jerusalem) : Targets for malaria
>drug development derived from basic research
>- Robert G. Ridley (WHO/TDR, Geneva, CH) : Developmental compounds in the
>pipeline for treatment and/or prophylaxis of malaria.
>- Deborah Kioy (WHO, Geneva, CH) : Essential toxicological and
>pharmacokinetic data needed before preclinical studies
>- John Horton (SKB, London, UK) Various steps from  preclinical phase to
>the clinical trials and marketing.
>
>SESSION V: ECONOMIC CONSIDERATIONS CONCERNING ANTIPARASITIC  DRUGS
>- Pascal MILLET, (Bordeaux, F) : How to create a link between fundamental
>research and the pharmaceutical industry in Tropical Medicine?
>- M. Traore (Mali, and INCO-DC, EU, Brussels, B) or Y. Yuthavong (Bangkok,
>Thailand) : Role of endemic countries in research and development.
>- Win Gutteridge (WHO/TDR, World bank, Geneva, CH) :  The New Medicines
>for Malaria Venture (MMV)
>- Palle Hoy Jakobsen (Denmark) :  Patent policy and strategies for
>tropical diseases: who and in which countries
>- John Horton (SKB, London, UK) : Private sector: defect of the industrial
>partner or lack of good compound.
>
>-------------------------------------------------------------
>LOCATION:
>
>The Symposium will be held at " LE CORUM ", Conference and Culture Centre
>in the heart of Montpellier, easily accessible from the "Montpellier
>Méditerranée" Airport, and the TGV high speed train station.
>Montpellier is Situated in the South of France, only a few miles from the
>Mediterranean Sea, Montpellier is the capital of the Languedoc-Roussillon
>Region.
>The international Montpellier-Mediterranée Airport is served by several
>international companies, including Air-France, British-Airways and
>Air-Littoral. Around 20 connecting flights with Paris are organised by
>three different companies. A regular bus service links the airport to the
>city centre.
>The High Speed Train (TGV) links in four hours and several times per day
>Montpellier with Paris. The TGV Railway Station is only five minutes
>walking distance from the "Corum" Conference and Cultural Centre.
>
>The A9 motorway passes by Montpellier. The easiest exit to reach the Corum
>Conference and Cultural Centre is "Montpellier-Est". Cars can be parked in
>the "Corum" Centre basement parking (Charge).
>-------------------------------------------------------------
>PRACTICAL INFORMATION
>
>The full text of the second announcement, including the electronic form
>for congress registration and lodging reservation form is available on our
>Web site at the following address : http ://162.38.196.39/drug-symposium/.
>Participants are encouraged to use electronic registration and
>accommodation form for lodging.
>For Hotel reservations : May 1st 1999 (See below)
>We invite you to register your travel arrangement and reserve your hotel
>as soon a possible. Indeed, the internal and, may be, international
>flights, may be overcrowded on this week end, as will be the hotels.
>
>-------------------------------------------------------------
>ORAL OR POSTER CONTRIBUTIONS: DEADLINES  AND INSTRUCTIONS FOR THE
>PREPARATION OF ABSTRACTS
>
>Participants wishing to present a contribution should submit an abstract
>following the format detailed below, not later than 26 March 1999 (oral
>contribution), or 15 April (poster contribution), to the address indicated
>above (secretariat of the conference).
>Full one-page abstracts will be reproduced directly from the authors'
>original documents. These should be typed using A4 formatted paper with
>the following format: Title (in bold), Author's names (NAME, I.N. in
>roman), Author's affiliation (in italic), body text (one column) They
>should have a length of approximately 400 words including title and
>eventual references. The name of the person presenting the paper should be
>underlined. Eventual references should be indicated within brackets in the
>text and listed at the bottom of the abstract. Abstracts should be
>submitted by e-mail (as attached file) to the following address:
>symposia@univ-montp2.fr, or failing that, on diskette (PC is
>preferred)(rtf file is the most appropriate), accompanied by two copies of
>the printed version, to the conference secretariat.
>Accepted papers for oral and poster contributions will be included in the
>conference programme and the book of abstracts only after receipt of the
>registration fees. However, the inclusion of presentation as an oral
>communication will be dependent on the final scientific programme, as
>numbers will be limited.  You will be informed of our decision before
>April 26th. If not included as an oral communication, you will be invited
>to present your paper as a poster. The abstract book including all
>lectures and oral and poster contributions will be handed out to the
>registered participants upon arrival.
>
>-------------------------------------------------------------
>REGISTRATION/ PAYMENTS
>
>The registration fees covers the following items :
>1. Participation in the Scientific Programme
>2. Conference material
>3.  Volume of abstracts
>4.  3 lunches + 1 cocktail
>5.  Coffee breaks
>The banquet is not included in the registration fees.
>All bank charges must be paid by the participant and your signature is
>essential for your registration.
>
>DEADLINES :
>Your registration will take effect from the moment when the payment
>arrives at our office. Accepted papers for oral and poster contributions
>will be included in the conference programme only after receipt of the
>registration fees. Registration will be confirmed if payment is received
>at the conference office by 30.04.1999. If your registration cannot arrive
>by 30.04.1999, you should register at the conference Office immediately
>after your arrival.
>
>-------------------------------------------------------------
>REGISTRATION FORM (CUT HERE)
>
>I hereby register for participation in the the Symposium DRUGS AGAINST
>PARASITIC DISEASES
>
>TITLE (Dr, Mr, Ms etc.)....	SURNAME....................FIRST
>NAME......................
>INSTITUTION/COMPAGNY...........................................................
>........
>ADDRESS........................................................................
>........
>...............................................................................
>........
>
>TEL............................	FAX..........................
>E-MAIL..................................................................
>
>I intend to present a paper/poster entitled :
>...............................................................................
>..........
>...............................................................................
>..........
>.........................................
>at session: ...............................................................
>
>Registration...................Before 15/04/1999..............After 15/04/1999
>Regular participant ...........1.200 FF or 213 US$............1.500 FF or
>266 US$
>CNRS participant...............1.000 FF.......................1.200 FF
>*Participation at the banquet .........350 FF or 62$
>(optional)
>TOTAL
>AMOUNT...................................................................
>
>HAS BEEN PAID THIS DAY BY /
>Bank transfer : Please indicate your name and the title of the symposium,
>domiciliation : tpmontpellier trésorerie générale - code banque : 10071 -
>code guichet : 34000 - n° de compte : 00003003417 - clé RIB : 66.
>or
>Purchase order or Bank cheque in Francs or Dollars, made out to "Agent
>Comptable du CNRS ".
>Please write on your registration form the total amount (conference fees,
>and eventually  banquet).
>
>Signature:
>
>Please fill in and return the enclosed registration form as soon as
>possible. All registrations, cancellations and alterations should be sent
>to :
>
>Conference Secretariat:
>Mme Christine BOUSQUET
>UMR 5539 CNRS/Université Montpellier II, cc107
>Place Eugène Bataillon
>34095 Montpellier cédex 5
>Tél. : (33) 4.67.14.42.87 Fax. : (33) 4.67.14.42.86
>E.Mail : symposia@univ-montp2.fr
>http://162.38.196.39/drug-symposium/.
>
>-------------------------------------------------------------------------------
>----
>HOTEL ACCOMMODATION
>DIRECTLY BY « LE CORUM »
>
>All participants have to fill in the attached form and send directly to «
>Le Corum » who will arrange reservations in hotels. We invite you to
>register your travel arrangement and reserve your hotel as soon a
>possible. Indeed, the internal and, may be, international flights, may be
>overcrowded on this week end, as will be the hotels.
>
>-------------------------------------------------------------------------------
>----
>ACCOMODATION FORM (CUT HERE)
>DRUGS AGAINST PARASITIC DISEASES
>MAY 24/26, 99
>
>FILL IN ONE REGISTRATION FORM PER PARTICIPANT IN CAPITAL LETTERS
>-SEND IT BACK WITH THE PAYMENT ENCLOSED BEFORE  MAY 1st, TO :
>
>STE LE CORUM -  SERVICE CONGRES - BP 2200 -  Esplanade Charles de Gaulle -
>34027 MONTPELLIER CEDEX1 - FRANCE
>Tel :  33 (0) 4 67  61 67 61/  Fax  : 33 (0) 67 61 66 84
>e.mail : corum@gestion-montpellier.fr
>
>Mr	Mrs	Drr	Pr
>
>
>FAMILY  NAME				FIRST NAME
>
>
>ADRESS
>
>
>
>
>ZIP  CODE 			CITY
>
>
>
>COUNTRY
>
>
>PHONE				FAX
>
>
>PLEASE RESERVE A HOTEL :	4 H	3 H Chain	3 Tradition H
>	2 H
>				or second choice
>
>
>.....room(s) for	......person(s)	Single		Double
>	twin beds
>
>
>I will arrive at Montpellier on May .........	  and will leave on
>May..........
>
>ACCOMMODATION FEE
>CLASS		PRICE MINI-PRICE MAXI	DEPOSIT AMOUNT
>4 H 		625 FF - 700 FF		565 FF	x..........
>3 H Chain 	480 FF - 600 FF		465 FF	x..........
>3 H Tradition	380 FF - 500 FF		365 FF	x...........
>2 H		300 FF - 400 FF		265 FF	x...........
>Tourist tax not included
>
>The table above indicates the approximate price for each room per night,
>with breakfast,V.A.T and service included (valid until December 31, 1999
>subject to change without notice
>For accommodation, the deposit amount includes 65 FF for processing.(i.e :
>Amount ex-VAT : 53,90 FF / VAT 20,60% 11,10 FF)
>Only applications received with payment enclosed will be considered.
>Accommodation forms received after May 1st, upon availability only.
>CANCELLATION : Deposits will be refunded only upon written cancellation
>addressed to LE CORUM (letter, fax or E.Mail) at least 15 working days
>before the beginning of the Congress. A fee of FF 65 (taxes included) will
>be deduced for processing
>
>PAYMENTS BY CHECKS : Please make your check payable to CORUM / HEBERGEMENT
>
>PAYMENTS BY SWIFT TRANSFER :.Code Swift : BWOR - FRPP.
>CORUM / HEBERGEMENT   -   N° 08 401 57 894  N  - Banque WORMS, 8 Bd Ledru
>Rollin, 34000 MONTPELLIER. - FRANCE
>PLEASE INFORM YOUR BANK THAT THE TRANSFER FEES MUST BE PAID BY THE ISSUER.
>
>PAYMENT: 	CHECK			SWIFT TRANSFER
>
>THE FORM SENT BY INTERNET DOES NOT REPRESENT A HOTEL RESERVATION.
>ONLY THE FORMS SENT BY MAIL WITH THE PAYMENT ENCLOSED WILL BE  PROCESSED.
>DATE								SIGNATURE :
>
>
>
>
>Symposia@univ-montp2.fr
>http://162.38.196.39/drug-symposium
>Henri VIAL/ Christine BOUSQUET
>UMR 5539 CNRS/Université Montpellier II, cc107
>Place Eugène Bataillon
>34095 Montpellier cédex 5, France
>Tél. : (33) 4.67.14.42.87 Fax. : (33) 4.67.14.42.86
>personal e-mail: vial@univ-montp2.fr
>




From owner-schistosoma@net.bio.net Mon Mar 15 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: Hooman Momen <hmomen@gene.dbbm.fiocruz.br>
Newsgroups: bionet.organisms.schistosoma
Subject: tdr Meegid-4
Date: 16 Mar 1999 01:14:18 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 83
Sender: daemon@net.bio.net
Approved: greveld@uni-duesseldorf.de
Distribution: world
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NNTP-Posting-Host: net.bio.net

-----------------------------------------------------------------------
-posted for tropical disease research community: "tdr-scientists list"
-----------------------------------------------------------------------

The Fourth International Meeting on Molecular Epidemiology and
Evolutionary Genetics of Infectious Diseases, will be held at
Dakar, Senegal, June 21-24,1999.

The three objective of these meetings are:

First, to integrate epidemiologic, molecular biologic, and evolutionary
genetics approaches in areas of diagnosis, strain typing, species
identification, pathogenesis, antigenic variation, drug and vaccine
resistance, and host and vector specificity.

Second, to foster interactions between epidemiologists and laboratory
scientists working on parasites, yeast and fungi, bacteria, and viruses.

Third, to provide health care providers, public health professionals,
policy makers, epidemiologists and laboratory scientists, and program managers
an opportunity to discuss the use of the genetic tools and methodologies
that are needed to meet the challenges of diagnosis and management of
emerging, re-emerging, and endemic infectious diseases.


 Submission of abstracts:

Abstracts should be about  250 words. Abstracts must be
received by March 31, 1999 and should be accompanied by the registration
fee Abstracts can be sent as an e-mail attachment or by diskette.

The proceedings of the meeting will be published  in the Journal of
Microbiological Methods.



Abstracts and  registration fees should be sent to

Michel Tibayrenc, Centre d'Etudes sur le Polymorphisme des
Microorganismes, IRD, BP 5045, 34032 Montpellier Cedex 1, France.
Phone 33 4 67 41 61 97
Fax 33 4 67 41 62 99
Email Michel.Tibayrenc@cepm.mpl.orstom.fr


 Further information  about the meeting can be obtained at the web site
for the event:

http://cepm.mpl.orstom.fr/

<><><><><><><><><><><><><><><><><><>
Hooman Momen Ph. D.
Instituto Oswaldo Cruz, FIOCRUZ
Av. Brasil 4365, Rio de Janeiro 21045-900, Brazil
email: hmomen@gene.dbbm.fiocruz.br

Chief, Department of Biochemistry and Molecular Biology
Fax: (+55-21)- 590-3495
Tel: (+55-21)- 598-4348 or 290-7549/or 7459/or 7071   Ext./Ramal 147

Editor, Memorias do Instituto Oswaldo Cruz
Fax: (+55-21)- 280-5048
Tel: (+55-21)- 598-4335
<><><><><><><><><><><><><><><><><><>




Dr.Christoph G.Grevelding
Genetic Parasitology
Institute of Genetic &
Center for Biological and Medical Research
Heinrich-Heine-Universitaet
Universitaetsstrasse 1
40225 Duesseldorf

Tel.:(49)-211-81-13070
Fax :(49)-211-81-12333
       (49)-211-81-12279
e-mail: Christoph.Grevelding@uni-duesseldorf.de
http://www.uni-duesseldorf.de/WWW/MathNat/Parasitologie/gen_para.htm 



From owner-schistosoma@net.bio.net Thu Mar 18 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: BIOSCI Administrator <biohelp@net.bio.net>
Newsgroups: bionet.organisms.schistosoma
Subject: BIOSCI/bionet miniFAQ & Fundraiser
Date: 19 Mar 1999 03:09:30 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
Lines: 235
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NNTP-Posting-Host: net.bio.net

>(LAST REVISION: 30-JUL-95)
>
>This BIOSCI "miniFAQ" is designed to answer the questions that come up
>the *most frequently*.  The main BIOSCI FAQ (Frequently Asked
>Questions) is accessible on the World Wide Web at URL
>http://www.bio.net/.
>
>If you can not find an answer to your question in this or other
>documentation, the BIOSCI technical support staff answers e-mail
>queries sent to
>
>		       biosci-help@net.bio.net
>
>We can only answer questions about the use of the newsgroups and
>mailing lists.  We unfortunately do not have the staff to do Internet
>information searches or answer scientific questions.  Please post
>those to the appropriate BIOSCI/bionet newsgroups.
>
>
>	Contents:
>	--------
>	0) BIOSCI NEEDS YOUR SUPPORT!!
>
>	1) Using the WWW to access the BIOSCI/bionet newsgroups.
>
>	2) What to do about "spams," i.e., junk mail, ads, etc.
>
>	3) Examples of subscribing and unsubscribing to the mailing lists.
>
>	4) The BIOSCI user address and research interest directory.
>
>
>0) BIOSCI NEEDS YOUR SUPPORT!!
>------------------------------
>BIOSCI's government funding has been expended, and we are now
>operating solely from advertising revenue that we have raised from our
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>
>You can do two important things which will take very little time for
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>
>First, please use our WWW system at http://www.bio.net/ to access the
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>tech support address, biosci-help@net.bio.net.
>
>
>1) Using the WWW to access the BIOSCI/bionet newsgroups.
>--------------------------------------------------------
>As of 10 December 1995, all BIOSCI/bionet full newsgroups are
>accessible through the World Wide Web (WWW) at URL http://www.bio.net.
>One can read and reply publicly or privately to both recent postings
>and archived messages through one's Web browser if it is configured
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>index.  The main BIOSCI home page also has access to the BIO-JOURNALS
>Table of Contents database WAIS index and the BIOSCI user address
>database described in another item further below.
>
>
>2) What to do about "spams," i.e., junk mail, ads, etc.
>-------------------------------------------------------
>BIOSCI is a set of parallel USENET newsgroups (the "bionet" groups),
>mailing lists, and a hypermail archive at URL http://www.bio.net/.
>The same postings are distributed on all media (except for a small
>number of mailing-list-only groups at net.bio.net).  Unfortunately it
>is becoming a despicable practice on the Internet (by a few people out
>to make a fast buck) to do automated mass postings to thousands of
>newsgroups and mailing lists.  These attempts to grab free advertising
>are refered to as "spams" in the usual, somewhat boneheaded, net
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>spams originate on the USENET groups and then are passed on to the
>mailing lists.  However, spammers also get lists of mailing addresses
>and hit these too, so neither medium is immune.
>
>What should you do personally if you get junk mail?
>---------------------------------------------------
>Just delete it and move on without reading it further.  Filing a
>protest is becoming increasingly useless because spammers are often
>disguising the addresses where the messages are sent from.  Unless you
>really understand Internet mail systems, your attempt at protest by
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>address of an innocent person that the spammer is victimizing.
>
>What can BIOSCI/bionet do to protect its newsgroups?
>----------------------------------------------------
>The only solution currently available is to moderate the newsgroup.
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>Most newsgroups currently have a discussion leader who is responsible
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>We will moderate any of our newsgroups if the discussion leader tells
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>Moderating a newsgroup will resolve probably 95% of the junk postings
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>
>3) Examples of subscribing and unsubscribing to the mailing lists.
>------------------------------------------------------------------
>PLEASE NOTE: The BIOSCI management does NOT act on
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>
>Gory details are in the BIOSCI Information sheets on the Web at
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>METHODS-AND-REAGENTS list at both of our two BIOSCI sites:
>
>Users in the Americas and Pacific Rim countries who use the BIOSCI
>------------------------------------------------------------------
>node at computer net.bio.net:
>----------------------------
>
>A) Determine the "listname" which is the <=8 character mail address
>                                         ^^^^^^^^^^^^^
>   for the group.  These can be found in the BIOSCI Info. Sheet.  For
>   the METHODS-AND-REAGENTS group the mailing address is
>   methods@net.bio.net.  The listname is the portion of the address to
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>   the "subscribe" and "unsubscribe" commands illustrated below.
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>
>Users in Europe, Africa, and Central Asia who use the BIOSCI node at
>--------------------------------------------------------------------
>computer daresbury.ac.uk (also known as dl.ac.uk):
>-------------------------------------------------
>
>To subscribe and unsubscribe to/from the BIOSCI lists, you need to
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>
>    sub bionet-news.bionet.molbio.methds-reagnts
>
>    unsub bionet-news.bionet.molbio.methds-reagnts
>
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>
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>
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>
>4) The BIOSCI user address and research interest directory.
>-----------------------------------------------------------
>Please take this opportunity to add your name, address, and research
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>
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From owner-schistosoma@net.bio.net Thu Mar 18 22:00:00 1999
Path: biosci!biosci!not-for-mail
From: Tom Moreels <Tom.Moreels@uia.ua.ac.be>
Newsgroups: bionet.organisms.schistosoma
Subject: Schistosomiasis epidemiology
Date: 19 Mar 1999 01:10:57 -0800
Organization: BIOSCI International Newsgroups for Molecular Biology
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Dear,

Where can I find a list (to be used as a reference) of the
worldwide prevalences of the main parasitic infections
(malaria, schistosomiasis...) ? What is the "ranking" of
schistosomiasis ?
Thank you.

Tom Moreels
University of Antwerp
Universiteitsplein 1
B-2610 Antwerp
Tom.Moreels@uia.ua.ac.be




