Cambridge Healthtech Institute’s
MOLECULAR EVOLUTION
April 24-25, 1997 Copley Plaza, Boston, Massachusetts
Co-sponsored by: Canji, Inc., Pharmacia Biotech, and PharmaGenics
A large number of biomedical applications involve the search for
compounds with improved activity or performance. The application of
molecular evolution is proving to be extremely well suited for this
purpose, particular for identification of nucleic acids or peptides.
Genetics makes it possible to employ sequential rounds of screening
and selection, followed by further mutation, to allow for the
generation of compounds adapted for a desired target or under specific
conditions. Phage display and other related techniques have been used
extensively for this purpose. Examples of the development of
antibodies, mutated proteins, and a range of research, selection, and
therapeutic applications are covered in detail. Learn how leaders in
this field are taking advantage of the power of this technology and
how you might benefit from making greater use of it by attending this
timely event.
NUCLEIC ACID EVOLUTION
In Vivo and In Vitro Applications of Nucleic Acid Ligands
Dr. Daniel W. Drolet, NeXstar Pharmaceuticals (confirmed)
Mirror-Image RNA Ligands
Dr. Jens P. Furste, Freie Universitst Berlin (confirmed)
Aptamer Evolution: Prospects for Diagnostics and Therapeutics
Dr. Andrew D. Ellington, Indiana University (confirmed)
Ribozymes from Random Sequences: Dr. David Bartel, Whitehead
Institute and Massachusetts Institute of Technology (confirmed)
ENGINEERING PROTEINS AND ANTIBODIES
Exploiting the Diversity of Large Human Antibody Libraries
Dr. John McCafferty, Cambridge Antibody Technology Ltd. (confirmed)
Molecular Evolution of Proteins, Pathways and Viruses by DNA Shuffling
Dr. Willem Stemmer, Maxygen, Inc. (confirmed)
In Vitro Selection of Peptides Acting on NMDA Glutamate Receptors
Dr. Min Li, John Hopkins School of Medicine (confirmed)
Synthesis Based Molecular Design of Antibodies and Proteins:
Dr. William D. Huse, Ixsys, Inc. (confirmed)
Dr. Manuel Baca, Genentech, Inc. (confirmed)
RESEARCH AND SELECTION USING PHAGE DISLAY
Cloning Novel Genes with Phage-Displayed Peptide Ligands
Dr. Brian Kay, University of North Carolina at Chapel Hill
(confirmed)
Adenovirus Expression Systems in Conjunction with Autofluorescent
Proteins: Potential Use in the Screening of Peptide Libraries
Dr. Luc Peloquin, Quantum Biotechnologies Inc. (confirmed)
Functional Epitope Mapping by Negative Selection of Phage-Displayed
Randomized Protein Libraries
Dr. Laurent Jespers, Flanders Interuniversity Institute for
Biotechnology (confirmed)
Automated Affinity Based Screening Using Serial Column Chromatography
Interfaced with Mass Spectrometry
Dr. Satish Jindal, ChemGenics Pharmaceuticals (confirmed)
Use of Combinatorially Generated Phage Displayed Ligands to Develop
Engineered Microprotein Ligands for Large Scale Biotherapeutic
Purification
Dr. John Maclennan, Dyax Corporation (confirmed)
Identification of Optimal Ligands for Protein Domains Using Oriented
Peptide Libraries
Dr. Zhou (Sonny) Songyang, Harvard Medical School (confirmed)
THERAPEUTIC DEVELOPMENTS USING PHAGE DISPLAY
Identification of Amino Acids Critical for the Activity of a Peptide
Mimetic of Erythropoietin and Discription of a Minimal Functional
Epitope
Dr. Dana Johnson, R.W. Johnson Pharmaceutical Research Institute
(confirmed)
Combinatorial Methods and Directed Evolution Applied to Staphylococcal
a-hemolysin, a Pore-Forming Protein
Dr. Hagan Bayley, Worcester Foundation for Biomedical Research
(confirmed)
Human Protein Display: A New System for Discovering Drug Binding
Targets
Dr. Allan Peng, GeneMax, Inc. (confirmed)
Novel Approaches for Targeting Tumors and Inhibiting Metastasis
Dr. Renata Pasqualini, La Jolla Cancer Research Center, The Burnham
Institute (confirmed)
Sampling Peptide Space for Cell-Targeting Peptides
Dr. Stephen A. Johnston, University of Texas, Southwestern Medical
Center, (confirmed)
Cloning Using Phage Display
Dr. Bob Shopes, Tera Biotechnology Corporation (confirmed)
Establishing Site Directed Assays Using Phage Displayed Libraries of
Peptides and Antibodies
Dr. Arthur J. Blume, DGI BioTechnologies, L.L.C. (confirmed)
